Title: Comparison of green tea intake in Japanese patients with and without angiographic coronary artery disease
Abstract: Flavonoids are polyphenolic antioxidants that are mainly found in beverages, such as tea and red wine, and in fruits and vegetables. We previously reported that the consumption of flavonoids from beverages increases the resistance of low-density lipoprotein to oxidation ex vivo. 1 Kondo K, Matsumoto A, Kurata H, Tanahashi H, Koda H, Amachi T, Itakura H. Inhibition of oxidation low-density lipoprotein with red wine. Lancet 1994;344:1152 Google Scholar , 2 Kondo K. Hirano R. Matsumoto A. Igarashi O. Itakura H. Inhibition of LDL oxidation by cocoa. Lancet. 1996; 348: 1514 Abstract Full Text Full Text PDF PubMed Scopus (184) Google Scholar Because low-density lipoprotein oxidation is recognized as a major step in atherogenesis, 3 Steinberg D. Parthasarathy S. Carew T.E. Khoo J.C. Witztum J.L. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989; 320: 915-924 Crossref PubMed Google Scholar the consumption of flavonoids may be protective against atherosclerosis. In addition to antioxidant activities, flavonoids were reported to have antithrombotic activities in vitro. 4 Laughton M.J. Evans P.J. Moroney M.A. Hoult J.R. Halliwell B. Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives relationship to antioxidant activity and to iron ion-reducing ability. Biochem Pharm. 1991; 42: 1673-1681 Crossref PubMed Scopus (591) Google Scholar , 5 Janssen K.P.L.T.M. Mensink R.P. Cox F.J. Harryvan J.L. Hovenier R. Hollman P.C. Katan M.B. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers results from an in vitro and a dietary supplement study. Am J Clin Nutr. 1998; 67: 255-262 PubMed Google Scholar Three prospective studies 6 Hertog M.G.L. Feskens E.J.M. Hollman P.C.H. Katan M.B. Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease the Zutphen Elderly Study. Lancet. 1993; 342: 1007-1011 Abstract PubMed Scopus (3912) Google Scholar , 7 Hertog M.G.L. Kromhout D. Aravanis C. Blackburn H. Buzina R. Fidanza F. Giampaoli S. Jansen A. Menotti A. Nedeljkovic S. et al. Flavonoids intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med. 1995; 155: 381-386 Crossref PubMed Scopus (1722) Google Scholar , 8 Knekt P. Jarvinen R. Reunanen A. Maatela J. Flavonoid intake and coronary mortality in Finland a cohort study. Br Med J. 1996; 312: 478-481 Crossref PubMed Scopus (1169) Google Scholar reported that the dietary intakes of flavonoids were associated with a reduced mortality from coronary artery disease (CAD). One prospective study 9 Hirvonen T. Pietinen P. Virtanen M. Ovaskainen M.L. Hakkinen S. Albanes D. Virtamo J. Intake of flavonols and flavones and risk of coronary heart disease in male smokers. Epidemiology. 2001; 12: 62-67 Crossref PubMed Scopus (149) Google Scholar also showed that the flavonoids intake was associated with a reduced risk of myocardial infarction (MI). Although the major sources for the flavonoids intake are wines in France and vegetables and fruits in the US, green tea, which is very rich in catechins, is the major source in Japan (>80% of flavonoid intakes). 7 Hertog M.G.L. Kromhout D. Aravanis C. Blackburn H. Buzina R. Fidanza F. Giampaoli S. Jansen A. Menotti A. Nedeljkovic S. et al. Flavonoids intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med. 1995; 155: 381-386 Crossref PubMed Scopus (1722) Google Scholar We hypothesized that green tea intake may be associated with a reduced risk of CAD or MI in Japanese. Why did green tea not protect against coronary artery disease but protect against myocardial infarction?American Journal of CardiologyVol. 91Issue 10Preview Full-Text PDF
Publication Year: 2002
Publication Date: 2002-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 62
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