Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2170349574', 'doi': 'https://doi.org/10.1126/science.287.5454.864', 'title': 'Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion', 'display_name': 'Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion', 'publication_year': 2000, 'publication_date': '2000-02-04', 'ids': {'openalex': 'https://openalex.org/W2170349574', 'doi': 'https://doi.org/10.1126/science.287.5454.864', 'mag': '2170349574', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10657302'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.287.5454.864', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026872836', 'display_name': 'Matthijs Verhage', 'orcid': 'https://orcid.org/0000-0002-6085-7503'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['NL', 'US'], 'is_corresponding': False, 'raw_author_name': 'Matthijs Verhage', 'raw_affiliation_strings': ['Center for Basic Neuroscience, Howard Hughes Medical Institute, and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.', 'Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.', 'institution_ids': ['https://openalex.org/I3018483916']}, {'raw_affiliation_string': 'Center for Basic Neuroscience, Howard Hughes Medical Institute, and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I867280407', 'https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071016744', 'display_name': 'Ascanio S. Maia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ascanio S. Maia', 'raw_affiliation_strings': ['Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083222024', 'display_name': 'Jaap J. Plomp', 'orcid': 'https://orcid.org/0000-0002-8427-9090'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jaap J. Plomp', 'raw_affiliation_strings': ['Departments of Neurology and Physiology, Leiden University Medical Centre, Leiden, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Neurology and Physiology, Leiden University Medical Centre, Leiden, Netherlands.', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021520721', 'display_name': 'Arjen B. Brussaard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Arjen B. Brussaard', 'raw_affiliation_strings': ['Department of Neurophysiology, Institute for Neurosciences, Vrije Universiteit Amsterdam, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurophysiology, Institute for Neurosciences, Vrije Universiteit Amsterdam, Netherlands.', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010996635', 'display_name': 'Joost H. Heeroma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Joost H. Heeroma', 'raw_affiliation_strings': ['Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111992350', 'display_name': 'Hendrika Vermeer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Hendrika Vermeer', 'raw_affiliation_strings': ['Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071375747', 'display_name': 'Ruud F. Toonen', 'orcid': 'https://orcid.org/0000-0002-9900-4233'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ruud F. Toonen', 'raw_affiliation_strings': ['Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands.', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111886445', 'display_name': 'Robert E. Hammer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert E. Hammer', 'raw_affiliation_strings': ['Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.'], 'affiliations': [{'raw_affiliation_string': 'Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103582800', 'display_name': 'Timo K. van den', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Timo K. van den', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105785087', 'display_name': 'Berg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'None Berg', 'raw_affiliation_strings': ['Department of Cell Biology and Immunology, Vrije Universiteit Amsterdam, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Immunology, Vrije Universiteit Amsterdam, Netherlands.', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086603873', 'display_name': 'Markus Missler', 'orcid': 'https://orcid.org/0000-0001-8008-984X'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Markus Missler', 'raw_affiliation_strings': ['Center for Basic Neuroscience, Howard Hughes Medical Institute, and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.'], 'affiliations': [{'raw_affiliation_string': 'Center for Basic Neuroscience, Howard Hughes Medical Institute, and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.', 'institution_ids': ['https://openalex.org/I867280407', 'https://openalex.org/I867280407', 'https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080897795', 'display_name': 'Hans J. Geuze', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Hans J. Geuze', 'raw_affiliation_strings': ['Department of Cell Biology, University of Utrecht, Utrecht, Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, University of Utrecht, Utrecht, Netherlands.', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061921730', 'display_name': 'Thomas C. Südhof', 'orcid': 'https://orcid.org/0000-0003-3361-9275'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas C. Südhof', 'raw_affiliation_strings': ['Center for Basic Neuroscience, Howard Hughes Medical Institute, and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.'], 'affiliations': [{'raw_affiliation_string': 'Center for Basic Neuroscience, Howard Hughes Medical Institute, and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I867280407', 'https://openalex.org/I867280407']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 23.09, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1395, 'citation_normalized_percentile': {'value': 0.999852, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '287', 'issue': '5454', 'first_page': '864', 'last_page': '869'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Axon Guidance and Neuronal Signaling', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurotransmitter-agents', 'display_name': 'Neurotransmitter Agents', 'score': 0.5492742}, {'id': 'https://openalex.org/keywords/synapsin', 'display_name': 'Synapsin', 'score': 0.4178866}], 'concepts': [{'id': 'https://openalex.org/C2776219046', 'wikidata': 'https://www.wikidata.org/wiki/Q162657', 'display_name': 'Neurotransmitter', 'level': 3, 'score': 0.83763903}, {'id': 'https://openalex.org/C148785051', 'wikidata': 'https://www.wikidata.org/wiki/Q671136', 'display_name': 'Synaptic vesicle', 'level': 4, 'score': 0.66682696}, {'id': 'https://openalex.org/C127445978', 'wikidata': 'https://www.wikidata.org/wiki/Q187181', 'display_name': 'Synapse', 'level': 2, 'score': 0.6479455}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.6207698}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.6202198}, {'id': 'https://openalex.org/C2910715078', 'wikidata': 'https://www.wikidata.org/wiki/Q162657', 'display_name': 'Neurotransmitter Agents', 'level': 4, 'score': 0.5492742}, {'id': 'https://openalex.org/C200170125', 'wikidata': 'https://www.wikidata.org/wiki/Q969316', 'display_name': 'Neurotransmission', 'level': 3, 'score': 0.5136463}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4662985}, {'id': 'https://openalex.org/C26987225', 'wikidata': 'https://www.wikidata.org/wiki/Q24769435', 'display_name': 'Synapsin', 'level': 5, 'score': 0.4178866}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.36497027}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.20799428}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.19344482}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.11016628}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09808335}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018377', 'descriptor_name': 'Neurotransmitter Agents', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D033921', 'descriptor_name': 'Vesicular Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017353', 'descriptor_name': 'Gene Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020439', 'descriptor_name': 'Growth Cones', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020439', 'descriptor_name': 'Growth Cones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051938', 'descriptor_name': 'Munc18 Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009434', 'descriptor_name': 'Neural Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D018377', 'descriptor_name': 'Neurotransmitter Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013572', 'descriptor_name': 'Synaptic Vesicles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013572', 'descriptor_name': 'Synaptic Vesicles', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D013572', 'descriptor_name': 'Synaptic Vesicles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.287.5454.864', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10657302', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1618714882', 'https://openalex.org/W1618814657', 'https://openalex.org/W1969036282', 'https://openalex.org/W1975923899', 'https://openalex.org/W1980795766', 'https://openalex.org/W1992156395', 'https://openalex.org/W1997750064', 'https://openalex.org/W2000142886', 'https://openalex.org/W2000269403', 'https://openalex.org/W2008515774', 'https://openalex.org/W2008766219', 'https://openalex.org/W2011680158', 'https://openalex.org/W2023902032', 'https://openalex.org/W2029600375', 'https://openalex.org/W2031904325', 'https://openalex.org/W2036562186', 'https://openalex.org/W2039871661', 'https://openalex.org/W2044162798', 'https://openalex.org/W2056986789', 'https://openalex.org/W2069105678', 'https://openalex.org/W2070603721', 'https://openalex.org/W2081985979', 'https://openalex.org/W2087938584', 'https://openalex.org/W2091738825', 'https://openalex.org/W2092423326', 'https://openalex.org/W2096721619', 'https://openalex.org/W2096925243', 'https://openalex.org/W2104407051', 'https://openalex.org/W2122121550', 'https://openalex.org/W2124248841', 'https://openalex.org/W2124433234', 'https://openalex.org/W2134505400', 'https://openalex.org/W2145375514', 'https://openalex.org/W2145537874', 'https://openalex.org/W2146785033', 'https://openalex.org/W2147502381', 'https://openalex.org/W2147611640', 'https://openalex.org/W2155553885', 'https://openalex.org/W2163967516', 'https://openalex.org/W2164477294', 'https://openalex.org/W2165302477', 'https://openalex.org/W2172586216'], 'related_works': ['https://openalex.org/W2584178521', 'https://openalex.org/W2074830850', 'https://openalex.org/W2074688705', 'https://openalex.org/W2037680312', 'https://openalex.org/W2033611838', 'https://openalex.org/W2032874774', 'https://openalex.org/W1998692418', 'https://openalex.org/W168957860', 'https://openalex.org/W1617322396', 'https://openalex.org/W1599287250'], 'abstract_inverted_index': {'Brain': [0], 'function': [1], 'requires': [2], 'precisely': [3], 'orchestrated': [4], 'connectivity': [5, 81], 'between': [6, 25], 'neurons.': [7, 27], 'Establishment': [8], 'of': [9, 29, 41, 59], 'these': [10], 'connections': [11], 'is': [12, 70], 'believed': [13], 'to': [14, 37, 76, 96], 'require': [15], 'signals': [16], 'secreted': [17], 'from': [18, 44], 'outgrowing': [19], 'axons,': [20], 'followed': [21], 'by': [22], 'synapse': [23], 'formation': [24, 58], 'selected': [26], 'Deletion': [28], 'a': [30, 38], 'single': [31], 'protein,': [32], 'Munc18-1,': [33], 'in': [34], 'mice': [35], 'leads': [36], 'complete': [39], 'loss': [40], 'neurotransmitter': [42, 86], 'secretion': [43, 93], 'synaptic': [45, 80, 100], 'vesicles': [46], 'throughout': [47], 'development.': [48], 'However,': [49], 'this': [50], 'does': [51, 82], 'not': [52, 83], 'prevent': [53], 'normal': [54], 'brain': [55], 'assembly,': [56], 'including': [57], 'layered': [60], 'structures,': [61], 'fiber': [62], 'pathways,': [63], 'and': [64], 'morphologically': [65], 'defined': [66], 'synapses.': [67], 'After': [68], 'assembly': [69], 'completed,': [71], 'neurons': [72], 'undergo': [73], 'apoptosis,': [74], 'leading': [75], 'widespread': [77], 'neurodegeneration.': [78], 'Thus,': [79], 'depend': [84], 'on': [85], 'secretion,': [87], 'but': [88], 'its': [89], 'maintenance': [90], 'does.': [91], 'Neurotransmitter': [92], 'probably': [94], 'functions': [95], 'validate': [97], 'already': [98], 'established': [99], 'connections.': [101]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2170349574', 'counts_by_year': [{'year': 2024, 'cited_by_count': 64}, {'year': 2023, 'cited_by_count': 46}, {'year': 2022, 'cited_by_count': 49}, {'year': 2021, 'cited_by_count': 64}, {'year': 2020, 'cited_by_count': 46}, {'year': 2019, 'cited_by_count': 53}, {'year': 2018, 'cited_by_count': 48}, {'year': 2017, 'cited_by_count': 61}, {'year': 2016, 'cited_by_count': 36}, {'year': 2015, 'cited_by_count': 56}, {'year': 2014, 'cited_by_count': 50}, {'year': 2013, 'cited_by_count': 51}, {'year': 2012, 'cited_by_count': 67}], 'updated_date': '2024-12-21T03:03:16.855698', 'created_date': '2016-06-24'}