Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2170346446', 'doi': 'https://doi.org/10.1016/j.ejmech.2006.02.004', 'title': 'Chemotherapy of leishmaniasis part III: synthesis and bioevaluation of novel aryl substituted terpenyl pyrimidines as antileishmanial agents', 'display_name': 'Chemotherapy of leishmaniasis part III: synthesis and bioevaluation of novel aryl substituted terpenyl pyrimidines as antileishmanial agents', 'publication_year': 2006, 'publication_date': '2006-06-01', 'ids': {'openalex': 'https://openalex.org/W2170346446', 'doi': 'https://doi.org/10.1016/j.ejmech.2006.02.004', 'mag': '2170346446', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16697490'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2006.02.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002737602', 'display_name': 'Naveen Chandra', 'orcid': 'https://orcid.org/0000-0002-5755-0025'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Naveen Chandra', 'raw_affiliation_strings': ['Division of\xa0Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of\xa0Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106458807', 'display_name': 'Susmita Pandey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Susmita Pandey', 'raw_affiliation_strings': ['Division of\xa0Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of\xa0Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103213434', 'display_name': 'Maneesha Vinodini Ramesh', 'orcid': 'https://orcid.org/0000-0002-3584-7143'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'None Ramesh', 'raw_affiliation_strings': ['Division of\xa0Parasitology, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of\xa0Parasitology, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019247440', 'display_name': 'S. N. Suryawanshi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'S.N. Suryawanshi', 'raw_affiliation_strings': ['Division of\xa0Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of\xa0Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103084887', 'display_name': 'Suman Gupta', 'orcid': 'https://orcid.org/0000-0001-7293-7423'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Suman Gupta', 'raw_affiliation_strings': ['Division of\xa0Parasitology, Central Drug Research Institute, Lucknow 226001, India'], 'affiliations': [{'raw_affiliation_string': 'Division of\xa0Parasitology, Central Drug Research Institute, Lucknow 226001, India', 'institution_ids': ['https://openalex.org/I185249246']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5019247440'], 'corresponding_institution_ids': ['https://openalex.org/I185249246'], 'apc_list': {'value': 4710, 'currency': 'USD', 'value_usd': 4710, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.849, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.830828, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '41', 'issue': '6', 'first_page': '779', 'last_page': '785'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10823', 'display_name': 'Global Burden of Leishmaniasis Incidence and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10823', 'display_name': 'Global Burden of Leishmaniasis Incidence and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10274', 'display_name': 'Heterocyclic Compounds for Drug Discovery', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T14099', 'display_name': 'Recent Advances in Triazine Chemistry', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/medicinal-chemistry', 'display_name': 'Medicinal Chemistry', 'score': 0.436859}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.93370044}, {'id': 'https://openalex.org/C2781076698', 'wikidata': 'https://www.wikidata.org/wiki/Q718074', 'display_name': 'Aryl', 'level': 3, 'score': 0.693287}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.54961324}, {'id': 'https://openalex.org/C114373084', 'wikidata': 'https://www.wikidata.org/wiki/Q273499', 'display_name': 'Chemical synthesis', 'level': 3, 'score': 0.48692596}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.47599232}, {'id': 'https://openalex.org/C2776555147', 'wikidata': 'https://www.wikidata.org/wiki/Q331283', 'display_name': 'Leishmaniasis', 'level': 2, 'score': 0.42144045}, {'id': 'https://openalex.org/C2781257258', 'wikidata': 'https://www.wikidata.org/wiki/Q1950789', 'display_name': 'Leishmania infantum', 'level': 4, 'score': 0.4201827}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.35186133}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.30265188}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17302442}, {'id': 'https://openalex.org/C2778689377', 'wikidata': 'https://www.wikidata.org/wiki/Q2046113', 'display_name': 'Visceral leishmaniasis', 'level': 3, 'score': 0.13093117}, {'id': 'https://openalex.org/C2780263894', 'wikidata': 'https://www.wikidata.org/wiki/Q335268', 'display_name': 'Alkyl', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000981', 'descriptor_name': 'Antiprotozoal Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007896', 'descriptor_name': 'Leishmaniasis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000981', 'descriptor_name': 'Antiprotozoal Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000981', 'descriptor_name': 'Antiprotozoal Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000981', 'descriptor_name': 'Antiprotozoal Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007893', 'descriptor_name': 'Leishmania donovani', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007893', 'descriptor_name': 'Leishmania donovani', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007896', 'descriptor_name': 'Leishmaniasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013055', 'descriptor_name': 'Spectrophotometry, Infrared', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2006.02.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16697490', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 14, 'referenced_works': ['https://openalex.org/W1549253571', 'https://openalex.org/W1964725483', 'https://openalex.org/W2042809651', 'https://openalex.org/W2057031709', 'https://openalex.org/W2060592209', 'https://openalex.org/W2066100912', 'https://openalex.org/W2072376345', 'https://openalex.org/W2098098358', 'https://openalex.org/W2105523385', 'https://openalex.org/W2132629073', 'https://openalex.org/W2950976143', 'https://openalex.org/W2951756473', 'https://openalex.org/W2953329328', 'https://openalex.org/W4248396965'], 'related_works': ['https://openalex.org/W63037195', 'https://openalex.org/W4255135668', 'https://openalex.org/W324504601', 'https://openalex.org/W3174562272', 'https://openalex.org/W3016729920', 'https://openalex.org/W2520998939', 'https://openalex.org/W2462334760', 'https://openalex.org/W2434556458', 'https://openalex.org/W2427615828', 'https://openalex.org/W2126683399'], 'abstract_inverted_index': {'Some': [0], 'aryl': [1], 'substituted': [2], 'terpenyl': [3], 'pyrimidines': [4], '4': [5], '(a-p)': [6], 'have': [7], 'been': [8], 'synthesized': [9], 'using': [10], 'novel': [11], 'synthetic': [12], 'methods.': [13], 'The': [14], 'compounds': [15], 'were': [16], 'screened': [17], 'for': [18], 'in': [19], 'vitro': [20], 'antileishmanial': [21], 'activity': [22], 'against': [23], 'promastigotes.': [24], 'Compounds': [25], '4c,': [26], '4i': [27], 'and': [28, 36], '4l': [29], 'showed': [30], 'IC(50)': [31], 'values': [32], 'as': [33], '35,': [34], '35': [35], '25': [37], 'microg': [38], 'ml(-1).': [39]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2170346446', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-14T22:34:59.640607', 'created_date': '2016-06-24'}