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'Howe': [95, 285], '05405': [107, 142, 181, 297, 332, 371], 'Cancer': [109, 144, 183, 299, 334, 373, 1091, 1261, 1528, 1660, 1858, 1985, 2129, 2178], 'Center,': [110, 145, 184, 300, 335, 374], 'authorCheung': [125, 315], 'Wong,': [126, 316], 'Cheung': [127, 317], 'Wong': [128, 318, 2066], 'Obstetrics': [131, 321], 'and': [132, 322, 428, 432, 444, 451, 470, 491, 499, 507, 544, 573, 584, 587, 606, 625, 632, 648, 719, 844, 881, 935, 1001, 1054, 1116, 1121, 1150, 1285, 1320, 1367, 1369, 1400, 1604, 1641, 1768, 1774, 1810, 1880, 1981, 2056, 2074, 2126, 2176, 2198], 'Gynecology,': [133, 323], 'authorKaren': [160, 350], 'Lounsbury,': [162, 352], 'Corresponding': [163, 353], 'Author': [164, 354], 'Karen': [165, 355], 'Lounsbury': [167, 357, 1016, 1538, 2070], '[email': [168, 358], 'protected]': [169, 359], '05405Department': [193, 383], '89': [199, 389], 'Beaumont': [200, 390], 'Avenue,': [201, 391], 'VT': [203, 393], '05405.Search': [204, 394], 'author': [210, 400, 792], 'First': [401], 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'LinkUse': [455], 'link': [457], 'a': [461, 476, 699, 810, 994, 1155, 1354, 1363, 1656, 1851, 1946], 'article': [466], 'with': [467, 489, 494, 571, 644, 1365, 1398, 1606, 1646], 'your': [468], 'friends': [469], 'colleagues.': [471], 'Learn': [472], 'more.Copy': [473], 'URL': [474], 'Share': [475], 'linkShare': [477], 'onEmailFacebookTwitterLinkedInRedditWechat': [478], 'Abstract': [479], 'Hypoxia': [480], 'inducible': [481], 'factor-1α': [482, 909, 1717, 1844], '(HIF-1α)': [483], 'stimulates': [484, 1401, 1941], 'expression': [485, 600, 880, 1080, 1118, 1845, 2076, 2159, 2200], 'genes': [487], 'associated': [488, 493, 643], 'angiogenesis': [490, 1525, 1907, 2175], 'is': [492, 505, 518, 529, 764, 809, 1081, 2052], 'poor': [495], 'outcomes': [496], 'in': [497, 525, 566, 592, 618, 634, 724, 747, 932, 1052, 1154, 1199, 1467, 1526, 1554, 1608, 1644, 1689, 1731, 1771, 1808, 1816, 1877, 1916, 2079, 2122, 2167], 'ovarian': [498, 553, 964, 1257, 2084], 'other': [500], 'cancers.': [501], 'In': [502], 'normoxia,': [503], 'ubiquitinated': [506, 635], 'degraded': [508], 'through': [509, 610, 717, 1085, 1504, 1850, 1908, 1945, 2201], 'E3': [511, 531, 1195], 'ubiquitin': [512, 532, 1196, 1328, 1969], 'ligase,': [513], 'von': [514], 'Hippel–Lindau;': [515], 'however,': [516], 'little': [517], 'known': [519], 'about': [520], 'hypoxic': [526, 687, 1721], 'conditions.': [527], 'FBW7': [528, 572, 611, 622, 638, 718, 1968], 'ligase': [533], 'that': [534, 561, 676, 708, 1549], 'recognizes': [535], 'proteins': [536, 1548], 'phosphorylated': [537], 'glycogen': [539, 1279], 'synthase': [540, 956, 1143, 1280, 1727, 1801], 'kinase': [541, 1144, 1728, 1802], '3β': [542, 1729], '(GSK3β)': [543], 'targets': [545, 723, 1600], 'them': [546], 'destruction.': [548], 'This': [549], 'study': [550], 'used': [551], 'cancer': [554, 965, 1258, 1878, 2170], 'cell': [555, 678, 689, 1321, 1978], 'model': [556], 'test': [558], 'hypothesis': [560], 'phosphorylation': [563, 661, 710, 1372, 1766], 'GSK3β': [565, 580, 660, 693], 'leads': [568], 'interaction': [570, 650, 1397], 'ubiquitin-dependent': [574, 715], 'degradation.': [575], 'Expression': [576], 'constitutively': [578], 'active': [579], 'reduced': [581], 'protein': [583, 1394, 1718, 1848], 'transcriptional': [585, 846, 912, 1403], 'activity': [586, 1775], 'increased': [588, 682, 2078], 'ubiquitination': [589], 'hypoxia,': [593], 'whereas': [594], 'pharmacologic': [595], 'inhibition': [596, 654], 'GSK3': [598, 656], 'or': [599, 657, 694, 770, 1650], 'siGSK3β': [602], 'promoted': [603], 'stabilization': [605, 620], 'activity.': [607, 847, 913, 1404], 'A': [608, 1521, 1545, 1971], 'mechanism': [609, 701], 'was': [612, 623, 639, 651, 671, 681], 'supported': [613, 672], 'observed': [616], 'decrease': [617, 633], 'when': [621, 637], 'overexpressed': [624], 'both': [626], 'elevation': [628], 'levels': [631], 'suppressed.': [640], 'Furthermore,': [641], 'FBW7γ': [645], 'co-immunoprecipitation,': [647], 'weakened': [652], 'mutation': 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[838], '2004.': [839, 1076, 1189, 2194], 'Sumoylation': [840], 'increases': [841], 'stability': [843, 1503], 'its': [845, 911, 1152, 1396, 1402, 1555], 'Biochem': [848, 914, 1024, 2206], 'Biophys': [849, 915, 2207], 'Res': [850, 916, 968, 1092, 1262, 1859, 1920, 2130, 2179, 2208], 'Commun': [851, 917, 2209], '324:': [852, 2210], '394–400.': [853], '10.1016/j.bbrc.2004.09.068': [854], 'Balamurugan': [859], 'K,': [860, 1417, 2020, 2140], 'Wang': [861], 'JM,': [862, 1244, 1248, 1250, 1429], 'Tsai': [863], 'HH,': [864], 'Sharan': [865], 'S,': [866, 985, 1341, 1343, 1349, 1488, 1759, 1931, 1996, 2034], 'Anver': [867], 'M,': [868, 900, 983, 1309, 1415, 1425, 1673, 1710, 1749, 1964, 2010, 2103], 'Leighty': [869], 'R,': [870, 1595, 1794], 'Sterneck': [871], 'E.': [872, 991, 1938], '2010.': [873, 1040, 1253, 1460, 1869], 'tumour': [875, 884, 1468, 1972], 'suppressor': [876, 1973], 'C/EBPδ': [877], 'inhibits': [878, 1114], 'FBXW7': [879, 1599], 'promotes': [882, 1370, 1906], 'mammary': [883], 'metastasis.': [885], '29:': [888, 1057, 1883], '4106–4117.': [889], '10.1038/emboj.2010.280': [890], 'Berta': [895], 'MA,': [896, 1271], 'Mazure': [897], 'N,': [898, 1708, 1827], 'Hattab': [899], 'Pouyssegur': [901], 'Brahimi-Horn': [903], 'MC.': [904], '2007.': [905, 992, 1141, 1499, 1519, 1571], 'SUMOylation': [906], 'hypoxia-inducible': [908, 1147, 1716, 1777, 1843, 1874, 1942, 2119, 2156], 'reduces': [910], '360:': [918], '646–652.': [919], '10.1016/j.bbrc.2007.06.103': [920], 'Bikfalvi': [925], 'Bicknell': [927], '2002.': [929, 1681, 1939], 'Recent': [930], 'advances': [931], 'angiogenesis,': [933], 'anti-angiogenesis': [934], 'vascular': [936, 1911], 'targeting.': [937], 'Trends': [938], 'Pharmacol': [939], 'Sci': [940], '23:': [941, 1206], '576–582.': [942], '10.1016/S0165-6147(02)02109-0': [943], 'Cao': [948, 1104], 'Q,': [949, 1492], 'Lu': [950], 'X,': [951], 'Feng': [952], 'YJ.': [953], '2006.': [954, 1762, 1838], 'Glycogen': [955, 1142, 1800], 'kinase-3beta': [957], 'positively': [958], 'regulates': [959, 1812], 'proliferation': [961], 'human': [963, 2124, 2168], 'cells.': [966, 1733, 1818, 1918], 'Cell': [967, 1006, 1023, 1159, 1331, 1471, 1507, 1576], '671–677.': [970], '10.1038/sj.cr.7310078': [971], 'Carbia-Nagashima': [976], 'Gerez': [978], 'Perez-Castro': [980], 'C,': [981, 1103, 1138, 1706, 1891, 1929, 1998, 2067, 2146], 'Paez-Pereda': [982], 'Silberstein': [984], 'Stalla': [986], 'GK,': [987], 'Holsboer': [988], 'F,': [989, 1482, 1675], 'Arzt': [990], 'RSUME,': [993], 'small': [995], 'RWD-containing': [996], 'protein,': [997], 'enhances': [998], 'SUMO': [999], 'conjugation': [1000], 'stabilizes': [1002], 'hypoxia.': [1005], '131:': [1007], '309–323.': [1008], '10.1016/j.cell.2007.07.044': [1009], 'KM.': [1017, 2071], 'Hypoxia-mediated': [1019], 'biological': [1020], 'control.': [1021], '735–744.': [1026], '10.1002/jcb.22956': [1027], 'Crusio': [1032], 'KM,': [1033, 1539, 2018], 'King': [1034], 'B,': [1035, 1490], 'Reavie': [1036], 'LB,': 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[1177], 'Fuchs': [1182], 'SY,': [1183], 'Spiegelman': [1184], 'VS,': [1185], 'Suresh': [1186], 'Kumar': [1187], 'KG.': [1188], 'many': [1191], 'faces': [1192], 'βTrCP': [1194], 'ligases:': [1197], 'Reflections': [1198], 'magic': [1201], 'mirror': [1202], 'cancer.': [1204, 1527, 2085], '2028–2036.': [1207], '10.1038/sj.onc.1207389': [1208], 'Goode': [1213], 'EL,': [1214], 'Maurer': [1215], 'MJ,': [1216, 2036], 'Sellers': [1217], 'TA,': [1218], 'Phelan': [1219], 'CM,': [1220], 'Kalli': [1221], 'KR,': [1222], 'Fridley': [1223], 'BL,': [1224], 'Vierkant': [1225], 'RA,': [1226], 'Armasu': [1227], 'SM,': [1228], 'White': [1229], 'KL,': [1230], 'Keeney': [1231], 'GL,': [1232, 1935, 2113], 'Cliby': [1233], 'WA,': [1234], 'Rider': [1235], 'DN,': [1236], 'Kelemen': [1237], 'LE,': [1238], 'Jones': [1239], 'MB,': [1240], 'Peethambaram': [1241], 'PP,': [1242], 'Lancaster': [1243], 'Olson': [1245], 'JE,': [1246, 1299], 'Schildkraut': [1247], 'Cunningham': [1249], 'Hartmann': [1251], 'LC.': [1252, 1570], 'Inherited': [1254], 'determinants': [1255], 'survival.': [1259], 'Clin': [1260], '995–1007.': [1264], '10.1158/1078-0432.CCR-09-2553': [1265], 'Gregory': [1270], 'Qi': [1272], 'Hann': [1274], 'SR.': [1275], '2003.': [1276, 1388, 1713, 2072], 'Phosphorylation': [1277], 'kinase-3': [1281], 'controls': [1282], 'c-myc': [1283], 'proteolysis': [1284], 'subnuclear': [1286], 'localization.': [1287], 'Chem': [1290, 1560, 1736, 1781, 1955], '278:': [1291, 1737], '51606–51612.': [1292], '10.1074/jbc.M310722200': [1293], 'Grim': [1298], 'Gustafson': [1300], 'MP,': [1301], 'Hirata': [1302], 'RK,': [1303], 'Hagar': [1304], 'Swanger': [1306], 'Welcker': [1308, 1963], 'Hwang': [1310], 'HC,': [1311, 1593], 'Ericsson': [1312], 'Russell': [1314], 'DW,': [1315], 'Clurman': [1316, 1965], 'BE.': [1317, 1966], '2008.': [1318, 1598, 1967], 'Isoform-': [1319], 'cycle-dependent': [1322], 'substrate': [1323], 'Fbw7': [1327], 'ligase.': [1329], '181:': [1333], '913–920.': [1334], '10.1083/jcb.200802076': [1335], 'Ikeda': [1340], 'Kishida': [1342], 'Yamamoto': [1344], 'Murai': [1346], 'Koyama': [1348], 'Kikuchi': [1350], '1998.': [1352], 'Axin,': [1353], 'negative': [1355], 'regulator': [1356, 1523], 'Wnt': [1359], 'pathway,': [1361], 'forms': [1362], 'GSK-3beta': [1366], 'beta-catenin': [1368], 'GSK-3beta-dependent': [1371], 'beta-catenin.': [1374], '17:': [1377], '1371–1384.': [1378], '10.1093/emboj/17.5.1371': [1379], 'Inna': [1384], 'MY,': [1385], 'Vadim': [1386], 'VS.': [1387], 'S-nitrosation': [1389], 'Cys-800': [1391], 'HIF-1alpha': [1393, 2075], 'activates': [1395], 'p300': [1399], 'FEBS': [1405], 'Lett': [1406], '549:': [1407], '105–109.': [1408], '10.1016/S0014-5793(03)00807-X': [1409], 'Ivan': [1414, 1672], 'Kondo': [1416], 'Yang': [1418, 1670], 'W,': [1421, 2002], 'Valiando': [1422], 'Ohh': [1424], 'Salic': [1426], 'Asara': [1428], 'Lane': [1430], 'WS,': [1431], 'Kaelin': [1432, 1676], 'WG,': [1433, 1677], 'Jr.': [1434], 'HIFalpha': [1436], 'targeted': [1437], 'VHL-mediated': [1439], 'destruction': [1440], 'proline': [1442], 'hydroxylation:': [1443], 'Implications': [1444, 2172], 'O2': [1446], 'sensing.': [1447], 'Science': [1448, 1611, 1691], '292:': [1449], '464–468.': [1450], '10.1126/science.1059817': [1451], 'Jokilehto': [1456], 'T,': [1457, 1899, 2000], 'Jaakkola': [1458], 'PM.': [1459], 'HIF': [1464], 'prolyl': [1465], 'hydroxylases': [1466], 'growth.': [1469], 'Med': [1473], '14:': [1474], '758–770.': [1475], '10.1111/j.1582-4934.2010.01030.x': [1476], 'Li': [1481, 1497], 'Sonveaux': [1483], 'P,': [1484, 2109], 'Rabbani': [1485], 'ZN,': [1486], 'Liu': [1487, 2011], 'Yan': [1489], 'Huang': [1491, 2043], 'Vujaskovic': [1493], 'Dewhirst': [1495], 'MW,': [1496], 'C-Y.': [1498], 'Regulation': [1500, 1714], 'S-nitrosylation.': [1505], '26:': [1508, 1531], '63–74.': [1509], '10.1016/j.molcel.2007.02.024': [1510], 'Liao': [1515], 'Johnson': [1517, 2023], 'Hypoxia:': [1520], 'key': [1522], 'Metastasis': [1529], 'Rev': [1530, 1984], '281–290.': [1532], '10.1007/s10555-007-9066-y': [1533], 'Beddow': [1540], 'AL,': [1541], 'Macara': [1542], 'IG.': [1543], '1994.': [1544], 'family': [1546, 1806], 'stabilize': [1550], 'Ran/TC4': [1552], 'GTPase': [1553], 'GTP-bound': [1556], 'conformation.': [1557], '269:': [1561], '11285–11290.': [1562], 'Manning': [1567], 'BD,': [1568], 'Cantley': [1569], 'AKT/PKB': [1572], 'signaling:': [1573], 'Navigating': [1574], 'downstream.': [1575], '129:': [1577], '1261–1274.': [1578], '10.1016/j.cell.2007.06.009': [1579], 'Mao': [1584], 'JH,': [1585], 'IJ,': [1587], 'Wu': [1588], 'Climent': [1590], 'Kang': [1592], 'DelRosario': [1594], 'Balmain': [1596], 'mTOR': [1601], 'cooperates': [1605], 'PTEN': [1607], 'tumor': [1609, 2174], 'suppression.': [1610], '321:': [1612], '1499–1502.': [1613], '10.1126/science.1162981': [1614], 'McGonigle': [1619], 'KF,': [1620], 'Muntz': [1621], 'HG,': [1622], 'Vuky': [1623], 'Paley': [1625], 'PJ,': [1626, 1792], 'Veljovich': [1627], 'DS,': [1628], 'Greer': [1629], 'BE,': [1630], 'Goff': [1631], 'BA,': [1632], 'Gray': [1633], 'HJ,': [1634], 'Malpass': [1635], 'TW.': [1636], 'Combined': [1638], 'weekly': [1639], 'topotecan': [1640], 'biweekly': [1642], 'bevacizumab': [1643], 'women': [1645], 'platinum-resistant': [1647], 'ovarian,': [1648], 'peritoneal,': [1649], 'fallopian': [1651], 'Results': [1654], 'phase': [1657], '2': [1658], 'study.': [1659], '117:': [1661], '3731–3740.': [1662], '10.1002/cncr.25967': [1663], 'Min': [1668], 'J-H,': [1669], 'Gertler': [1674], 'Jr.,': [1678], 'Pavletich': [1679], 'NP.': [1680], 'Structure': [1682], 'HIF-1alpha-pVHL': [1685], 'complex:': [1686], 'Hydroxyproline': [1687], 'recognition': [1688], '296:': [1692], '1886–1889.': [1693], '10.1126/science.1073440': [1694], 'Mottet': [1699], 'Dumont': [1701], 'V,': [1702], 'Deccache': [1703], 'Demazy': [1705], 'Ninane': [1707], 'Raes': [1709], 'level': [1719], 'conditions': [1722], 'phosphatidylinositol': [1725, 1947], '3-kinase/Akt/glycogen': [1726], 'HepG2': [1732], '31277–31285.': [1738], '10.1074/jbc.M300763200': [1739], 'Mylonis': [1744], 'I,': [1745], 'Chachami': [1746], 'G,': [1747, 1751], 'Samiotaki': [1748], 'Panayotou': [1750], 'Paraskeva': [1752], 'Kalousi': [1754], 'Georgatsou': [1756], 'Bonanou': [1758], 'Simos': [1760], 'G.': [1761], 'Identification': [1763], 'MAPK': [1765], 'sites': [1767], 'their': [1769, 1813, 2127], 'localization': [1773], 'factor-1α.': [1778], '281:': [1782], '33095–33106.': [1783], '10.1074/jbc.M605058200': [1784], 'Nikolakaki': [1789], 'Coffer': [1791], 'Hemelsoet': [1793], 'Woodgett': [1795], 'JR,': [1796, 2028], 'Defize': [1797], 'LH.': [1798], '1993.': [1799], 'Jun': [1805], 'members': [1807], 'vitro': [1809], 'negatively': [1811], 'transactivating': [1814], 'potential': [1815], 'intact': [1817], '8:': [1820, 1986], '833–840.': [1821], 'Pore': [1826], 'Shu': [1830], 'H-K,': [1831], 'Bernhard': [1832], 'Kao': [1834], 'GD,': [1835], 'Maity': [1836], 'Akt1': [1839], 'activation': [1840, 1909], 'can': [1841], 'augment': [1842], 'increasing': [1847], 'translation': [1849], 'mammalian': [1852], 'rapamycin-independent': [1855], '4:': [1860], '471–479.': [1861], '10.1158/1541-7786.MCR-05-0234': [1862], 'Semenza': [1867, 1934, 2112, 2151], 'GL.': [1868, 2152], 'Defining': [1870], '1': [1876, 1944], 'biology': [1879], 'therapeutics.': [1881, 2177], '625–634.': [1884], '10.1038/onc.2009.441': [1885], 'Skurk': [1890], 'Maatz': [1892], 'Rocnik': [1894], 'Bialik': [1896], 'Force': [1898], 'Walsh': [1900], 'Glycogen-synthase': [1903], 'kinase3beta/beta-catenin': [1904], 'axis': [1905], 'growth': [1913, 1980, 2163], 'Circ': [1919], '96:': [1921], '308–318.': [1922], '10.1161/01.RES.0000156273.30274.f7': [1923], 'Treins': [1928], 'Giorgetti-Peraldi': [1930], 'Murdaca': [1932], 'Van': [1936], 'Obberghen': [1937], 'Insulin': [1940], '3-kinase/target': [1948], 'rapamycin-dependent': [1950], '277:': [1956], '27975–27981.': [1957], '10.1074/jbc.M204152200': [1958], 'ligase:': [1970], 'at': [1974], 'crossroads': [1976], 'division,': [1979], 'differentiation.': [1982], 'Nat': [1983], '83–93.': [1987], '10.1038/nrc2290': [1988], 'Wertz': [1993], 'IE,': [1994], 'Kusam': [1995], 'Lam': [1997], 'Okamoto': [1999], 'Sandoval': [2001], 'Anderson': [2003], 'DJ,': [2004], 'Helgason': [2005], 'Ernst': [2007], 'Eby': [2009], 'Belmont': [2013], 'LD,': [2014], 'Kaminker': [2015], 'JS,': [2016], "O'Rourke": [2017], 'Pujara': [2019], 'Kohli': [2021], 'PB,': [2022], 'AR,': [2024], 'Chiu': [2025], 'ML,': [2026], 'Lill': [2027], 'Jackson': [2029], 'PK,': [2030], 'Fairbrother': [2031], 'WJ,': [2032], 'Seshagiri': [2033], 'Ludlam': [2035], 'Leong': [2037], 'KG,': [2038], 'Dueber': [2039], 'EC,': [2040], 'Maecker': [2041], 'DC,': [2044], 'Dixit': [2045], 'VM.': [2046], 'Sensitivity': [2048], 'antitubulin': [2050], 'chemotherapeutics': [2051], 'regulated': [2053], 'MCL1': [2055], 'Nature': [2058], '471:': [2059], '110–114.': [2060], '10.1038/nature09779': [2061], 'TL,': [2069], 'are': [2077], 'advanced': [2080], 'stages': [2081], 'epithelial': [2083], 'Gynecol': [2086], '91:': [2088], '513–517.': [2089], '10.1016/j.ygyno.2003.08.022': [2090], 'Zhong': [2095, 2137, 2186], 'De': [2097], 'Marzo': [2098], 'AM,': [2099], 'Laughner': [2100, 2143], 'Lim': [2102], 'Hilton': [2104], 'DA,': [2105], 'Zagzag': [2106], 'Buechler': [2108], 'Isaacs': [2110], 'WB,': [2111], 'Simons': [2114, 2149], 'JW.': [2115], '1999.': [2116], 'Overexpression': [2117], '1alpha': [2121], 'common': [2123], 'cancers': [2125], 'metastases.': [2128], '59:': [2131], '5830–5835.': [2132], 'Chiles': [2139], 'Feldser': [2141], 'Hanrahan': [2145], 'Georgescu': [2147], 'M-M,': [2148], 'JW,': [2150], '2000.': [2153], 'Modulation': [2154], 'epidermal': [2162], 'factor/phosphatidylinositol': [2164], '3-kinase/PTEN/AKT/FRAP': [2165], 'prostate': [2169], 'cells:': [2171], '60:': [2180], '1541–1545.': [2181], 'X-S,': [2187], 'SU5416': [2195], 'inhibited': [2196], '471–480.': [2211], '10.1016/j.bbrc.2004.09.082': [2212], 'Citing': [2217], 'Literature': [2218], 'Volume112,': [2219], 'Issue12December': [2220], '2011Pages': [2221], 'ReferencesRelatedInformation': [2223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2170275592', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-17T03:12:10.549572', 'created_date': '2016-06-24'}