Publication Information

{'id': 'https://openalex.org/W2170091723', 'doi': 'https://doi.org/10.1128/iai.68.12.6932-6938.2000', 'title': 'Interleukin-18 (IL-18) Enhances Innate IL-12-Mediated Resistance to<i>Toxoplasma gondii</i>', 'display_name': 'Interleukin-18 (IL-18) Enhances Innate IL-12-Mediated Resistance to<i>Toxoplasma gondii</i>', 'publication_year': 2000, 'publication_date': '2000-12-01', 'ids': {'openalex': 'https://openalex.org/W2170091723', 'doi': 'https://doi.org/10.1128/iai.68.12.6932-6938.2000', 'mag': '2170091723', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11083816', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/97801'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.68.12.6932-6938.2000', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/iai.68.12.6932-6938.2000', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111729128', 'display_name': 'Guifang Cai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guifang Cai', 'raw_affiliation_strings': ['Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania,1 and'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania,1 and', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018250332', 'display_name': 'Robert Kastelein', 'orcid': 'https://orcid.org/0000-0002-7318-6884'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Kastelein', 'raw_affiliation_strings': ['Department of Molecular Biology, DNAX Research Institute, Palo Alto, California2'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, DNAX Research Institute, Palo Alto, California2', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003951398', 'display_name': 'Christopher A. Hunter', 'orcid': 'https://orcid.org/0000-0003-3092-1428'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher A. Hunter', 'raw_affiliation_strings': ['Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania,1 and'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania,1 and', 'institution_ids': ['https://openalex.org/I79576946']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.11, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 115, 'citation_normalized_percentile': {'value': 0.903374, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '68', 'issue': '12', 'first_page': '6932', 'last_page': '6938'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11155', 'display_name': 'Toxoplasma gondii Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11155', 'display_name': 'Toxoplasma gondii Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11078', 'display_name': 'Inflammasome and immune disorders', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/interleukin-15', 'display_name': 'Interleukin 15', 'score': 0.41873127}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.81452715}, {'id': 'https://openalex.org/C2778128430', 'wikidata': 'https://www.wikidata.org/wiki/Q131003', 'display_name': 'Toxoplasma gondii', 'level': 3, 'score': 0.7832689}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.7140925}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.6692466}, {'id': 'https://openalex.org/C149532602', 'wikidata': 'https://www.wikidata.org/wiki/Q2409681', 'display_name': 'Interleukin 12', 'level': 4, 'score': 0.6032242}, {'id': 'https://openalex.org/C193419808', 'wikidata': 'https://www.wikidata.org/wiki/Q1645075', 'display_name': 'Acquired immune system', 'level': 3, 'score': 0.49954653}, {'id': 'https://openalex.org/C2779341262', 'wikidata': 'https://www.wikidata.org/wiki/Q182581', 'display_name': 'Immunity', 'level': 3, 'score': 0.49431467}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.44912788}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.43494734}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.42084134}, {'id': 'https://openalex.org/C98119934', 'wikidata': 'https://www.wikidata.org/wiki/Q14907167', 'display_name': 'Interleukin 15', 'level': 4, 'score': 0.41873127}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.34058285}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.14779261}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.1282695}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018664', 'descriptor_name': 'Interleukin-12', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020382', 'descriptor_name': 'Interleukin-18', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D014124', 'descriptor_name': 'Toxoplasmosis, Animal', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.68.12.6932-6938.2000', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc97801', 'pdf_url': 'https://europepmc.org/articles/pmc97801?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC97801', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11083816', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.68.12.6932-6938.2000', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.75, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W130851191', 'https://openalex.org/W1487549623', 'https://openalex.org/W1499740654', 'https://openalex.org/W1501206772', 'https://openalex.org/W1517678415', 'https://openalex.org/W1526950608', 'https://openalex.org/W1553735692', 'https://openalex.org/W1556867369', 'https://openalex.org/W1559694381', 'https://openalex.org/W1580262749', 'https://openalex.org/W1595574785', 'https://openalex.org/W1629901235', 'https://openalex.org/W1641753670', 'https://openalex.org/W1814850137', 'https://openalex.org/W1819325258', 'https://openalex.org/W1822880402', 'https://openalex.org/W1896675849', 'https://openalex.org/W1925420621', 'https://openalex.org/W1933250835', 'https://openalex.org/W1942062746', 'https://openalex.org/W195731949', 'https://openalex.org/W1963964762', 'https://openalex.org/W1988563171', 'https://openalex.org/W1998047654', 'https://openalex.org/W2007029345', 'https://openalex.org/W2022383700', 'https://openalex.org/W2023803780', 'https://openalex.org/W2026161448', 'https://openalex.org/W2028500185', 'https://openalex.org/W2030000864', 'https://openalex.org/W2041345462', 'https://openalex.org/W2052895824', 'https://openalex.org/W2061665489', 'https://openalex.org/W2067394439', 'https://openalex.org/W2084300389', 'https://openalex.org/W2099872746', 'https://openalex.org/W2100457010', 'https://openalex.org/W2106196303', 'https://openalex.org/W2116457898', 'https://openalex.org/W2117252842', 'https://openalex.org/W2122511642', 'https://openalex.org/W2122534786', 'https://openalex.org/W2127314810', 'https://openalex.org/W2134139967', 'https://openalex.org/W2135254713', 'https://openalex.org/W2143774231', 'https://openalex.org/W2146965501', 'https://openalex.org/W2149579127', 'https://openalex.org/W2149673255', 'https://openalex.org/W2149917645', 'https://openalex.org/W2152420574', 'https://openalex.org/W2153279598', 'https://openalex.org/W2154218327', 'https://openalex.org/W2160515243', 'https://openalex.org/W2166899308', 'https://openalex.org/W2171831396', 'https://openalex.org/W2208015810', 'https://openalex.org/W3147018784', 'https://openalex.org/W340354993', 'https://openalex.org/W4313306023', 'https://openalex.org/W4313308240', 'https://openalex.org/W4313310005', 'https://openalex.org/W4313331914', 'https://openalex.org/W4313347710', 'https://openalex.org/W4313376929', 'https://openalex.org/W4313379471', 'https://openalex.org/W87420729'], 'related_works': ['https://openalex.org/W4235353359', 'https://openalex.org/W2552812348', 'https://openalex.org/W2388776418', 'https://openalex.org/W2378893564', 'https://openalex.org/W2350222396', 'https://openalex.org/W2229058835', 'https://openalex.org/W2126519126', 'https://openalex.org/W2022383700', 'https://openalex.org/W1997279356', 'https://openalex.org/W1547523787'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Innate': [1], 'resistance': [2, 57, 87, 168, 196], 'to': [3, 14, 49, 58, 65, 88, 97, 115, 166, 169, 189, 197, 209], 'Toxoplasma': [4], 'gondii': [5, 60, 71, 171, 199], 'is': [6, 27], 'dependent': [7, 173], 'on': [8, 174], 'the': [9, 51, 133, 148, 161], 'ability': [10, 162], 'of': [11, 21, 31, 34, 53, 63, 80, 94, 105, 120, 136, 142, 150, 163], 'interleukin-12': [12], '(IL-12)': [13], 'stimulate': [15], 'natural': [16], 'killer': [17], '(NK)': [18], 'cell': [19, 127], 'production': [20, 33, 104], 'gamma': [22], 'interferon': [23], '(IFN-γ).': [24], 'Since': [25], 'IL-18': [26, 54, 96, 121, 165, 187, 203], 'a': [28, 111, 191], 'potent': [29], 'enhancer': [30], 'IL-12-induced': [32], 'IFN-γ': [35, 81], 'by': [36], 'NK': [37, 126, 178, 206], 'cells,': [38], 'SCID': [39, 66, 99], 'mice': [40, 67, 100], '(which': [41], 'lack': [42], 'an': [43, 74], 'adaptive': [44], 'immune': [45], 'response)': [46], 'were': [47], 'used': [48], 'assess': [50], 'role': [52, 193], 'in': [55, 73, 77, 102, 113, 147, 155, 194], 'innate': [56, 195], 'T.': [59, 70, 170, 198], '.': [61], 'Administration': [62], 'anti-IL-18': [64], 'infected': [68, 98], 'with': [69, 124, 139, 202], 'resulted': [72, 101], 'early': [75], 'reduction': [76], 'serum': [78], 'levels': [79, 141], 'but': [82], 'did': [83], 'not': [84], 'significantly': [85], 'decrease': [86], 'this': [89, 210], 'infection.': [90], 'In': [91, 153], 'contrast,': [92], 'administration': [93, 137], 'exogenous': [95, 164], 'increased': [103, 125], 'IFN-γ,': [106, 176], 'reduced': [107], 'parasite': [108], 'burden,': [109], 'and': [110, 129, 138, 177], 'delay': [112], 'time': [114], 'death.': [116], 'The': [117], 'protective': [118], 'effects': [119], 'treatment': [122, 201], 'correlated': [123], 'numbers': [128], 'cytotoxic': [130], 'activity': [131], 'at': [132], 'local': [134], 'site': [135], 'elevated': [140], 'inducible': [143], 'nitrous': [144], 'oxide': [145], 'synthose': [146], 'spleens': [149], 'treated': [151], 'mice.': [152], 'addition,': [154], 'vivo': [156], 'depletion': [157], 'studies': [158, 182], 'demonstrated': [159], 'that': [160, 184], 'enhance': [167], 'was': [172], 'IL-12,': [175], 'cells.': [179], 'Together,': [180], 'these': [181], 'demonstrate': [183], 'although': [185], 'endogenous': [186], 'appears': [188], 'have': [190], 'limited': [192], ',': [200], 'can': [204], 'augment': [205], 'cell-mediated': [207], 'immunity': [208], 'pathogen.': [211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2170091723', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-10T00:10:34.102789', 'created_date': '2016-06-24'}