Title: Chelation‐Controlled Intermolecular Hydroacylation: Direct Addition of Alkyl Aldehydes to Functionalized Alkenes
Abstract: Angewandte Chemie International EditionVolume 43, Issue 3 p. 340-343 Communication Chelation-Controlled Intermolecular Hydroacylation: Direct Addition of Alkyl Aldehydes to Functionalized Alkenes† Michael C. Willis Dr., Michael C. Willis Dr. [email protected] Department of Chemistry, University of Bath, Bath, BA2 7AY, UK, Fax: (+44) 1225-38-6231Search for more papers by this authorSteven J. McNally, Steven J. McNally Department of Chemistry, University of Bath, Bath, BA2 7AY, UK, Fax: (+44) 1225-38-6231Search for more papers by this authorPaul J. Beswick Dr., Paul J. Beswick Dr. Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UKSearch for more papers by this author Michael C. Willis Dr., Michael C. Willis Dr. [email protected] Department of Chemistry, University of Bath, Bath, BA2 7AY, UK, Fax: (+44) 1225-38-6231Search for more papers by this authorSteven J. McNally, Steven J. McNally Department of Chemistry, University of Bath, Bath, BA2 7AY, UK, Fax: (+44) 1225-38-6231Search for more papers by this authorPaul J. Beswick Dr., Paul J. Beswick Dr. Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UKSearch for more papers by this author First published: 29 December 2003 https://doi.org/10.1002/anie.200352751Citations: 123 † This work was supported by the EPSRC, the University of Bath, and GlaxoSmithKline. We also thank the EPSRC Mass Spectrometry service at the University of Wales, Swansea. Dr. A. Weller and Mr. A. Rifat are thanked for their help in the preparation of catalyst 2. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The pendant methylsulfanyl group of aldehyde 1 provides chelation stabilization (see 3), thus allowing direct hydroacylation of functionalized electron-poor alkenes 2 in good yields under mild conditions. Electron-deficient alkynes can also be used as substrates. R=ester, amide, imide, sulfone; dppe=1,2-bis(diphenylphosphanyl)ethane. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52751_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume43, Issue3January 5, 2004Pages 340-343 RelatedInformation
Publication Year: 2003
Publication Date: 2003-12-29
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 130
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