Title: Semi-synthesis and proteasome inhibition of <scp>D</scp>-ring deoxy analogs of (–)-epigallocatechin gallate (EGCG), the active ingredient of green tea extract
Abstract:A semi-synthetic route to the D-ring analogs of (–)-epigallocatechin gallate (EGCG) from the relatively abundant (–)-epigallocatechin (EGC), isolated from green tea leaves, is described. A natural pro...A semi-synthetic route to the D-ring analogs of (–)-epigallocatechin gallate (EGCG) from the relatively abundant (–)-epigallocatechin (EGC), isolated from green tea leaves, is described. A natural product (13), found in Cistus salvifolius, its acetate (14) and analog (17) were synthesized by this method. Their inhibitory activities against proteasomes were investigated.Key words: green tea, (–)-epigallocatechin gallate (EGCG), (–)-epigallocatechin (EGC), proteasome inhibition.Read More
Publication Year: 2008
Publication Date: 2008-05-16
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 12
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