Publication Information

{'id': 'https://openalex.org/W2169573863', 'doi': 'https://doi.org/10.1080/095530098141500', 'title': 'Mechanisms of the anti-inflammatory activity of low-dose radiation therapy', 'display_name': 'Mechanisms of the anti-inflammatory activity of low-dose radiation therapy', 'publication_year': 1998, 'publication_date': '1998-01-01', 'ids': {'openalex': 'https://openalex.org/W2169573863', 'doi': 'https://doi.org/10.1080/095530098141500', 'mag': '2169573863', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9737539'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/095530098141500', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44383424', 'display_name': 'International Journal of Radiation Biology', 'issn_l': '0955-3002', 'issn': ['0955-3002', '1362-3095'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079590708', 'display_name': 'Michael Seed', 'orcid': 'https://orcid.org/0000-0001-7053-4743'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'G. HILDEBRANDT M. P. SEED C. N. FREEMA', 'raw_affiliation_strings': ["Experimental Pathology, Saint Bartholomew's and the Royal London School ofMedicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.", 'Radiation Biology and'], 'affiliations': [{'raw_affiliation_string': "Experimental Pathology, Saint Bartholomew's and the Royal London School ofMedicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.", 'institution_ids': []}, {'raw_affiliation_string': 'Radiation Biology and', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5079590708'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.859, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 144, 'citation_normalized_percentile': {'value': 0.981227, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '74', 'issue': '3', 'first_page': '367', 'last_page': '378'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10958', 'display_name': 'Ultrasound and Hyperthermia Applications', 'score': 0.9751, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.7581308}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.68424463}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.677603}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.611652}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5569141}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.5258575}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.45807737}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4548595}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.41745168}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29239285}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25529107}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004307', 'descriptor_name': 'Dose-Response Relationship, Radiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D006099', 'descriptor_name': 'Granuloma', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006099', 'descriptor_name': 'Granuloma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008262', 'descriptor_name': 'Macrophage Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D011879', 'descriptor_name': 'Radiotherapy Dosage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/095530098141500', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44383424', 'display_name': 'International Journal of Radiation Biology', 'issn_l': '0955-3002', 'issn': ['0955-3002', '1362-3095'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9737539', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1540820582', 'https://openalex.org/W1834041853', 'https://openalex.org/W1860105952', 'https://openalex.org/W1968374691', 'https://openalex.org/W2005872884', 'https://openalex.org/W2007737411', 'https://openalex.org/W2013911376', 'https://openalex.org/W2038548539', 'https://openalex.org/W2044192395', 'https://openalex.org/W2048187420', 'https://openalex.org/W2059588207', 'https://openalex.org/W2067069905', 'https://openalex.org/W2075141353', 'https://openalex.org/W2079760972', 'https://openalex.org/W2114298357', 'https://openalex.org/W2117388675', 'https://openalex.org/W2119145731', 'https://openalex.org/W2128635872', 'https://openalex.org/W2130282385', 'https://openalex.org/W2150882549', 'https://openalex.org/W2159069239', 'https://openalex.org/W2163945685', 'https://openalex.org/W2243702269', 'https://openalex.org/W2277778131', 'https://openalex.org/W2398135969', 'https://openalex.org/W2410815379'], 'related_works': ['https://openalex.org/W247954563', 'https://openalex.org/W2414653455', 'https://openalex.org/W2371602709', 'https://openalex.org/W2256974744', 'https://openalex.org/W2126157643', 'https://openalex.org/W2098776639', 'https://openalex.org/W2085967611', 'https://openalex.org/W2018075260', 'https://openalex.org/W2002027447', 'https://openalex.org/W1990842025'], 'abstract_inverted_index': {'AbstractPurpose:': [0], 'To': [1], 'investigate': [2], 'the': [3, 8, 16, 19, 30, 122, 169, 178, 190, 221], 'hypothesis': [4], 'that': [5], 'modulation': [6, 167, 212], 'of': [7, 10, 15, 18, 26, 32, 35, 117, 168, 204, 213, 216], 'function': [9], 'activated': [11], 'macrophages': [12, 72], 'is': [13], 'one': [14], 'mechanisms': [17], 'clinically': [20], 'observed': [21, 173], 'anti-inflammatory': [22, 184, 202], 'and': [23, 44, 47, 59, 98, 130, 144], 'analgesic': [24], 'efficacy': [25], 'low-dose': [27], 'radiotherapy': [28, 185, 203], 'in': [29, 73, 96, 134, 183, 195, 225], 'treatment': [31], 'a': [33, 149, 165], 'variety': [34], 'painful': [36], 'joint': [37], 'diseases': [38, 206], 'with': [39, 104, 113, 174, 187], 'total': [40], 'doses': [41, 82, 116, 153, 181, 193], 'between': [42], '1': [43], '6Gy.': [45], 'Materials': [46], 'methods:': [48], 'Metabolic': [49], 'activity,': [50, 142], 'cell': [51], 'proliferation,': [52], 'reproductive': [53, 145], 'integrity,': [54], 'nitric': [55, 61, 222], 'oxide': [56, 62, 223], '(NO)': [57], 'production': [58], 'inducible': [60], 'synthase': [63], '(iNOS)': [64], 'expression': [65, 124], 'by': [66, 127, 132, 151, 177, 189], 'unstimulated': [67], 'or': [68, 102, 109, 112], 'LPS/': [69], 'gamma': [70], '-IFN-stimulated': [71], 'vitro': [74], 'was': [75, 125, 172], 'investigated': [76], 'at': [77], 'different': [78, 214], 'times': [79], 'after': [80], 'radiation': [81, 152, 180, 192], 'ranging': [83], 'from': [84], '0.3Gy': [85], 'to': [86, 155, 208], '10Gy.': [87], 'In': [88, 138], 'vivo,': [89], 'chronic': [90], 'granulomatous': [91], 'air': [92], 'pouches': [93], 'were': [94, 147], 'induced': [95], 'mice': [97], 'either': [99], 'sham': [100], 'treated': [101], 'irradiated': [103], '2Gy': [105], 'on': [106], 'day': [107, 110, 120], '2': [108], '6,': [111], 'five': [114], 'daily': [115], '0.5Gy.': [118], 'On': [119], '7,': [121], 'iNOS': [123], 'assessed': [126], 'Western': [128], 'blot': [129], 'localized': [131], 'immuno-histochemistry': [133], 'cryostat': [135], 'sections.': [136], 'Results:': [137], 'stimulated': [139, 226], 'macrophages,': [140], 'metabolic': [141], 'proliferation': [143], 'integrity': [146], 'not': [148], 'ffected': [150], 'up': [154], '10Gy': [156], 'since': [157], 'they': [158], 'are': [159], 'apparently': [160], 'irreversible': [161], 'postmitotic': [162], 'cells.': [163], 'However,': [164], 'dose-dependent': [166], 'NO': [170], 'pathway': [171, 224], 'significant': [175], 'inhibition': [176], 'low': [179], 'used': [182, 194], 'but': [186], 'super-stimulation': [188], 'high': [191], 'cancer': [196], 'therapy.': [197], 'Conclusions:': [198], 'The': [199], 'empirically': [200], 'based': [201], 'benign': [205], 'appears': [207], 'act': [209], 'through': [210], 'specific': [211], 'pathways': [215], 'inflammatory': [217], 'reactions': [218], 'such': [219], 'as': [220], 'macrophages.': [227]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2169573863', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-14T21:42:05.118674', 'created_date': '2016-06-24'}