Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2169430911', 'doi': 'https://doi.org/10.18632/oncotarget.1904', 'title': 'Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer', 'display_name': 'Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer', 'publication_year': 2014, 'publication_date': '2014-04-17', 'ids': {'openalex': 'https://openalex.org/W2169430911', 'doi': 'https://doi.org/10.18632/oncotarget.1904', 'mag': '2169430911', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25153719', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4171603'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1904', 'pdf_url': 'https://www.oncotarget.com/article/1904/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/1904/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072739938', 'display_name': 'Siti Norasikin Mohd Nafi', 'orcid': 'https://orcid.org/0000-0002-0642-0909'}, 'institutions': [{'id': 'https://openalex.org/I2802742124', 'display_name': 'John Radcliffe Hospital', 'ror': 'https://ror.org/0080acb59', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802742124', 'https://openalex.org/I4210127145', 'https://openalex.org/I4210147381']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Siti Norasikin Mohd Nafi', 'raw_affiliation_strings': ['Human Epidermal Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Human Epidermal Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK', 'institution_ids': ['https://openalex.org/I2802742124', 'https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020078965', 'display_name': 'Daniele Generali', 'orcid': 'https://orcid.org/0000-0003-2480-3855'}, 'institutions': [{'id': 'https://openalex.org/I4210165579', 'display_name': 'Istituti Ospitalieri di Cremona', 'ror': 'https://ror.org/05w07vs91', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165579']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Daniele Generali', 'raw_affiliation_strings': ['U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy'], 'affiliations': [{'raw_affiliation_string': 'U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy', 'institution_ids': ['https://openalex.org/I4210165579']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006116515', 'display_name': 'Gabriela Krämer-Marek', 'orcid': 'https://orcid.org/0000-0002-8053-3880'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gabriela Kramer-Marek', 'raw_affiliation_strings': ['Institute of Cancer Research, Division of Radiotherapy and Imaging, 15 Cotswold Road, Belmont, Sutton, Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Research, Division of Radiotherapy and Imaging, 15 Cotswold Road, Belmont, Sutton, Surrey, UK', 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036009351', 'display_name': 'Merel Gijsen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802742124', 'display_name': 'John Radcliffe Hospital', 'ror': 'https://ror.org/0080acb59', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802742124', 'https://openalex.org/I4210127145', 'https://openalex.org/I4210147381']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Merel Gijsen', 'raw_affiliation_strings': ['Human Epidermal Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Human Epidermal Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK', 'institution_ids': ['https://openalex.org/I2802742124', 'https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071939535', 'display_name': 'Carla Strina', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210165579', 'display_name': 'Istituti Ospitalieri di Cremona', 'ror': 'https://ror.org/05w07vs91', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165579']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Carla Strina', 'raw_affiliation_strings': ['U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy'], 'affiliations': [{'raw_affiliation_string': 'U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy', 'institution_ids': ['https://openalex.org/I4210165579']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062166707', 'display_name': 'Mariarosa Cappelletti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210165579', 'display_name': 'Istituti Ospitalieri di Cremona', 'ror': 'https://ror.org/05w07vs91', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165579']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mariarosa Cappelletti', 'raw_affiliation_strings': ['U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy'], 'affiliations': [{'raw_affiliation_string': 'U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy', 'institution_ids': ['https://openalex.org/I4210165579']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024279311', 'display_name': 'Daniele Andreis', 'orcid': 'https://orcid.org/0000-0001-6686-5662'}, 'institutions': [{'id': 'https://openalex.org/I4210165579', 'display_name': 'Istituti Ospitalieri di Cremona', 'ror': 'https://ror.org/05w07vs91', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165579']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Daniele Andreis', 'raw_affiliation_strings': ['U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy'], 'affiliations': [{'raw_affiliation_string': 'U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy', 'institution_ids': ['https://openalex.org/I4210165579']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052903538', 'display_name': 'Syed Haider', 'orcid': 'https://orcid.org/0000-0001-6685-5480'}, 'institutions': [{'id': 'https://openalex.org/I2802742124', 'display_name': 'John Radcliffe Hospital', 'ror': 'https://ror.org/0080acb59', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802742124', 'https://openalex.org/I4210127145', 'https://openalex.org/I4210147381']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Syed Haider', 'raw_affiliation_strings': ['Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK', 'institution_ids': ['https://openalex.org/I2802742124', 'https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012186529', 'display_name': 'Ji-Liang Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802742124', 'display_name': 'John Radcliffe Hospital', 'ror': 'https://ror.org/0080acb59', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802742124', 'https://openalex.org/I4210127145', 'https://openalex.org/I4210147381']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ji-Liang Li', 'raw_affiliation_strings': ['Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK', 'institution_ids': ['https://openalex.org/I2802742124', 'https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023518824', 'display_name': 'Esther Bridges', 'orcid': 'https://orcid.org/0000-0002-6958-6279'}, 'institutions': [{'id': 'https://openalex.org/I2802742124', 'display_name': 'John Radcliffe Hospital', 'ror': 'https://ror.org/0080acb59', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802742124', 'https://openalex.org/I4210127145', 'https://openalex.org/I4210147381']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Esther Bridges', 'raw_affiliation_strings': ['Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK', 'institution_ids': ['https://openalex.org/I2802742124', 'https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041336753', 'display_name': 'Jacek Capala', 'orcid': 'https://orcid.org/0000-0001-7631-0310'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jacek Capala', 'raw_affiliation_strings': ['National Institutes of Health, Radiation Oncology Branch, Bethesda MD, US'], 'affiliations': [{'raw_affiliation_string': 'National Institutes of Health, Radiation Oncology Branch, Bethesda MD, US', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038968301', 'display_name': 'Ioannis Roxanis', 'orcid': 'https://orcid.org/0000-0002-9920-514X'}, 'institutions': [{'id': 'https://openalex.org/I4210146357', 'display_name': 'Oxford BioMedica (United Kingdom)', 'ror': 'https://ror.org/03dp0vf82', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210146357']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Roxanis Ioannis', 'raw_affiliation_strings': ['Department of Cellular Pathology, Oxford University Hospitals and Oxford Biomedical Research Centre, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular Pathology, Oxford University Hospitals and Oxford Biomedical Research Centre, Oxford, UK', 'institution_ids': ['https://openalex.org/I4210146357', 'https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079633934', 'display_name': 'Adrian L. Harris', 'orcid': 'https://orcid.org/0000-0003-1376-8409'}, 'institutions': [{'id': 'https://openalex.org/I2802742124', 'display_name': 'John Radcliffe Hospital', 'ror': 'https://ror.org/0080acb59', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802742124', 'https://openalex.org/I4210127145', 'https://openalex.org/I4210147381']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Adrian L Harris', 'raw_affiliation_strings': ['Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK', 'institution_ids': ['https://openalex.org/I2802742124', 'https://openalex.org/I40120149']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071537151', 'display_name': 'Anthony Kong', 'orcid': 'https://orcid.org/0000-0002-3989-3948'}, 'institutions': [{'id': 'https://openalex.org/I2802742124', 'display_name': 'John Radcliffe Hospital', 'ror': 'https://ror.org/0080acb59', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802742124', 'https://openalex.org/I4210127145', 'https://openalex.org/I4210147381']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Anthony Kong', 'raw_affiliation_strings': ['Human Epidermal Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Human Epidermal Growth Factor Group, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK', 'institution_ids': ['https://openalex.org/I2802742124', 'https://openalex.org/I40120149']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5071537151'], 'corresponding_institution_ids': ['https://openalex.org/I2802742124', 'https://openalex.org/I40120149'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.942, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 58, 'citation_normalized_percentile': {'value': 0.91176, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '5', 'issue': '15', 'first_page': '5934', 'last_page': '5949'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10755', 'display_name': 'HER2 Signaling in Breast Cancer Treatment', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10755', 'display_name': 'HER2 Signaling in Breast Cancer Treatment', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/her2', 'display_name': 'HER2', 'score': 0.53766}, {'id': 'https://openalex.org/keywords/breast-cancer', 'display_name': 'Breast Cancer', 'score': 0.534911}, {'id': 'https://openalex.org/keywords/trastuzumab', 'display_name': 'Trastuzumab', 'score': 0.531825}, {'id': 'https://openalex.org/keywords/lapatinib', 'display_name': 'Lapatinib', 'score': 0.51095575}], 'concepts': [{'id': 'https://openalex.org/C2779786085', 'wikidata': 'https://www.wikidata.org/wiki/Q412616', 'display_name': 'Trastuzumab', 'level': 4, 'score': 0.9476538}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.7372047}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7004952}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.5646263}, {'id': 'https://openalex.org/C2777329042', 'wikidata': 'https://www.wikidata.org/wiki/Q420323', 'display_name': 'Lapatinib', 'level': 5, 'score': 0.51095575}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4789132}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.46651495}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44462788}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42052662}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D018719', 'descriptor_name': 'Receptor, ErbB-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D066247', 'descriptor_name': 'Receptor, ErbB-4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000068878', 'descriptor_name': 'Trastuzumab', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064593', 'descriptor_name': 'Heterografts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018719', 'descriptor_name': 'Receptor, ErbB-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066247', 'descriptor_name': 'Receptor, ErbB-4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068878', 'descriptor_name': 'Trastuzumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 8, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1904', 'pdf_url': 'https://www.oncotarget.com/article/1904/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4171603', 'pdf_url': 'https://europepmc.org/articles/pmc4171603?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171603', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://birmingham.elsevierpure.com/en/publications/9e3c6fbb-3e9a-491f-8f03-3dc205703ef3', 'pdf_url': 'https://birmingham.elsevierpure.com/files/103291526/MohdNafiSN2014Nuclear.pdf', 'source': {'id': 'https://openalex.org/S4306402634', 'display_name': 'University of Birmingham Research Portal (University of Birmingham)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I79619799', 'host_organization_name': 'University of Birmingham', 'host_organization_lineage': ['https://openalex.org/I79619799'], 'host_organization_lineage_names': ['University of Birmingham'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://pure-oai.bham.ac.uk/ws/files/103291526/MohdNafiSN2014Nuclear.pdf', 'pdf_url': 'http://pure-oai.bham.ac.uk/ws/files/103291526/MohdNafiSN2014Nuclear.pdf', 'source': {'id': 'https://openalex.org/S4306402634', 'display_name': 'University of Birmingham Research Portal (University of Birmingham)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I79619799', 'host_organization_name': 'University of Birmingham', 'host_organization_lineage': ['https://openalex.org/I79619799'], 'host_organization_lineage_names': ['University of Birmingham'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10026.1/10330', 'pdf_url': 'https://pearl.plymouth.ac.uk/bitstream/10026.1/10330/1/1904-19867-5-PB.pdf', 'source': {'id': 'https://openalex.org/S4306402507', 'display_name': 'PEARL (University of Plymouth)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I897542642', 'host_organization_name': 'University of Plymouth', 'host_organization_lineage': ['https://openalex.org/I897542642'], 'host_organization_lineage_names': ['University of Plymouth'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10026.1/5251', 'pdf_url': 'https://pearl.plymouth.ac.uk/bitstream/10026.1/5251/1/Nuclear%20HER4%20mediates%20acquired%20resistance%20to%20trastuzumab%20and%20is%20associated%20with%20poor%20outcome%20in%20HER2%20positive%20breast%20cancer.pdf', 'source': {'id': 'https://openalex.org/S4306402507', 'display_name': 'PEARL (University of Plymouth)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I897542642', 'host_organization_name': 'University of Plymouth', 'host_organization_lineage': ['https://openalex.org/I897542642'], 'host_organization_lineage_names': ['University of Plymouth'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25153719', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1904', 'pdf_url': 'https://www.oncotarget.com/article/1904/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1501995929', 'https://openalex.org/W1597931794', 'https://openalex.org/W1970446746', 'https://openalex.org/W1973310884', 'https://openalex.org/W1978421730', 'https://openalex.org/W1985103551', 'https://openalex.org/W1985620074', 'https://openalex.org/W2006257247', 'https://openalex.org/W2007245209', 'https://openalex.org/W2007435673', 'https://openalex.org/W2010536491', 'https://openalex.org/W2015722063', 'https://openalex.org/W2019116727', 'https://openalex.org/W2020837693', 'https://openalex.org/W2023460670', 'https://openalex.org/W2023578257', 'https://openalex.org/W2028061086', 'https://openalex.org/W2034009919', 'https://openalex.org/W2037980730', 'https://openalex.org/W2051051838', 'https://openalex.org/W2053015255', 'https://openalex.org/W2053673624', 'https://openalex.org/W2054443407', 'https://openalex.org/W2065097865', 'https://openalex.org/W2072339545', 'https://openalex.org/W2072677891', 'https://openalex.org/W2074320983', 'https://openalex.org/W2075059021', 'https://openalex.org/W2086491111', 'https://openalex.org/W2089952471', 'https://openalex.org/W2090433709', 'https://openalex.org/W2090855460', 'https://openalex.org/W2093440393', 'https://openalex.org/W2094313894', 'https://openalex.org/W2095366249', 'https://openalex.org/W2096772550', 'https://openalex.org/W2098487226', 'https://openalex.org/W2099010186', 'https://openalex.org/W2107038774', 'https://openalex.org/W2107863839', 'https://openalex.org/W2112369586', 'https://openalex.org/W2114195503', 'https://openalex.org/W2115736838', 'https://openalex.org/W2116790599', 'https://openalex.org/W2123415105', 'https://openalex.org/W2133565210', 'https://openalex.org/W2140840142', 'https://openalex.org/W2144677406', 'https://openalex.org/W2149169512', 'https://openalex.org/W2150185773', 'https://openalex.org/W2154246971', 'https://openalex.org/W2164694479', 'https://openalex.org/W2166655074', 'https://openalex.org/W2326264021', 'https://openalex.org/W2409820727', 'https://openalex.org/W4244087642'], 'related_works': ['https://openalex.org/W67104293', 'https://openalex.org/W2989981638', 'https://openalex.org/W2509762766', 'https://openalex.org/W2333897269', 'https://openalex.org/W2262572336', 'https://openalex.org/W2167587342', 'https://openalex.org/W2166148619', 'https://openalex.org/W2001196910', 'https://openalex.org/W1967506091', 'https://openalex.org/W1964065629'], 'abstract_inverted_index': {'//': [0, 169], 'Siti': [1], 'Norasikin': [2], 'Mohd': [3], 'Nafi': [4], '1': [5, 17, 57, 58], ',': [6, 10, 14, 18, 22, 26, 30, 37, 41, 45, 49, 167], 'Daniele': [7, 27], 'Generali': [8], '4': [9, 21, 25, 29, 111], 'Gabriela': [11], 'Kramer-Marek': [12], '6': [13, 147], 'Merel': [15], 'Gijsen': [16], 'Carla': [19], 'Strina': [20], 'Mariarosa': [23], 'Cappelletti': [24], 'Andreis': [28], 'Syed': [31], 'Haider': [32], '2': [33, 36, 40, 53, 80], 'Ji-Liang': [34], 'Li': [35], 'Esther': [38], 'Bridges': [39], 'Jacek': [42], 'Capala': [43], '3': [44, 100], 'Roxanis': [46], 'Ioannis': [47], '5': [48, 132], 'Adrian': [50], 'L': [51], 'Harris': [52], 'and': [54, 140, 155, 203, 218, 226, 239, 256, 269, 287, 309, 353, 359, 373, 376], 'Anthony': [55, 165], 'Kong': [56, 166], 'Human': [59], 'Epidermal': [60], 'Growth': [61, 81], 'Factor': [62, 82], 'Group,': [63, 83], 'Department': [64, 84, 133], 'of': [65, 69, 73, 85, 89, 93, 103, 134, 149, 153, 196, 231, 380], 'Oncology,': [66, 86], 'Weatherall': [67, 87], 'Institute': [68, 88, 148], 'Molecular': [70, 90], 'Medicine,': [71, 91], 'University': [72, 92, 138], 'Oxford,': [74, 78, 94, 98, 145], 'John': [75, 95], 'Radcliffe': [76, 96], 'Hospital,': [77, 97], 'UK': [79, 99, 146, 163], 'National': [101], 'Institutes': [102], 'Health,': [104], 'Radiation': [105], 'Oncology': [106], 'Branch,': [107], 'Bethesda': [108], 'MD,': [109], 'US': [110], 'U.O.': [112], 'Multidisciplinare': [113], 'di': [114, 125], 'Patologia': [115], 'Mammaria,': [116], 'U.S': [117], 'Terapia': [118], 'Molecolare': [119], 'e': [120], 'Farmacogenomica,': [121], 'A.O.': [122], 'Instituti': [123], 'Ospitalieri': [124], 'Cremona,': [126, 130], 'Viale': [127], 'Concordia': [128], '1,': [129, 181], 'Italy': [131], 'Cellular': [135], 'Pathology,': [136], 'Oxford': [137, 141], 'Hospitals': [139], 'Biomedical': [142], 'Research': [143], 'Centre,': [144], 'Cancer': [150], 'Research,': [151], 'Division': [152], 'Radiotherapy': [154], 'Imaging,': [156], '15': [157], 'Cotswold': [158], 'Road,': [159], 'Belmont,': [160], 'Sutton,': [161], 'Surrey,': [162], 'Correspondence:': [164], 'email:': [168], 'Keywords': [170], ':': [171, 179, 184, 189], 'breast': [172, 199, 246, 322, 341, 364, 392], 'cancer,': [173], 'HER4,': [174], 'HER2,': [175], 'trastuzumab,': [176], 'resistance': [177, 210, 221, 242, 337, 360, 388], 'Received': [178], 'February': [180], '2014': [182, 187, 192], 'Accepted': [183], 'April': [185, 190], '16,': [186], 'Published': [188], '17,': [191], 'Abstract': [193], 'The': [194], 'role': [195, 205, 332, 379], 'HER4': [197, 223, 232, 250, 258, 266, 278, 295, 328, 350, 367, 381], 'in': [198, 206, 243, 280, 303, 319, 333, 338, 361, 389], 'cancer': [200, 247], 'is': [201], 'controversial': [202], 'its': [204, 219, 241], 'relation': [207, 334], 'to': [208, 300, 312, 335, 385], 'trastuzumab': [209, 216, 237, 271, 301, 336, 357, 387], 'remains': [211], 'unclear.': [212], 'We': [213], 'showed': [214], 'that': [215, 327, 349], 'treatment': [217], 'acquired': [220], 'induced': [222], 'upregulation,': [224], 'cleavage': [225, 251, 352], 'nuclear': [227, 267, 277, 294, 354], 'translocation.': [228], 'However,': [229], 'knockdown': [230], 'by': [233, 252, 262], 'specific': [234], 'siRNAs': [235], 'increased': [236, 276], 'sensitivity': [238, 358], 'reversed': [240], 'HER2': [244, 320, 339, 362, 390], 'positive': [245, 321, 340, 363, 391], 'cells.': [248], 'Preventing': [249], 'a': [253, 306, 330, 370], 'γ-secretase': [254], 'inhibitor': [255], 'inhibiting': [257], 'tyrosine': [259], 'kinase': [260], 'activity': [261], 'neratinib': [263], 'decreased': [264], 'trastuzumab-induced': [265], 'translocation': [268, 355], 'enhanced': [270], 'response.': [272], 'There': [273], 'was': [274, 310], 'also': [275], 'staining': [279], 'the': [281, 378], 'tumours': [282], 'from': [283], 'BT474': [284], 'xenograft': [285], 'mice': [286], 'human': [288], 'patients': [289, 304], 'treated': [290], 'with': [291], 'trastuzumab.': [292], 'Furthermore,': [293], 'predicted': [296], 'poor': [297, 316], 'clinical': [298], 'response': [299], 'monotherapy': [302], 'undergoing': [305], 'window': [307], 'study': [308, 345], 'shown': [311], 'be': [313, 369], 'an': [314], 'independent': [315], 'prognostic': [317, 372], 'factor': [318], 'cancer.': [323, 342, 365, 393], 'Our': [324], 'data': [325], 'suggest': [326], 'plays': [329], 'key': [331], 'Therefore,': [343], 'our': [344], 'provides': [346], 'novel': [347], 'findings': [348], 'activation,': [351], 'influence': [356], 'Nuclear': [366], 'could': [368], 'potential': [371], 'predictive': [374], 'biomarker': [375], 'understanding': [377], 'may': [382], 'provide': [383], 'strategies': [384], 'overcome': [386]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2169430911', 'counts_by_year': [{'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-09-16T19:48:18.548060', 'created_date': '2016-06-24'}