Publication Information

{'id': 'https://openalex.org/W2169427225', 'doi': None, 'title': 'Enhanced oral absorption and decreased elimination of paclitaxel in mice cotreated with cyclosporin A.', 'display_name': 'Enhanced oral absorption and decreased elimination of paclitaxel in mice cotreated with cyclosporin A.', 'publication_year': 1998, 'publication_date': '1998-10-01', 'ids': {'openalex': 'https://openalex.org/W2169427225', 'mag': '2169427225', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9796957'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9796957', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078756591', 'display_name': 'Judith van Asperen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'J van Asperen', 'raw_affiliation_strings': ['Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034151807', 'display_name': 'Olaf van Tellingen', 'orcid': 'https://orcid.org/0000-0002-1037-6269'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'O van Tellingen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072137272', 'display_name': 'Martin A. van der Valk', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M A van der Valk', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076558660', 'display_name': 'M Rozenhart', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M Rozenhart', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062227574', 'display_name': 'Jos H. Beijnen', 'orcid': 'https://orcid.org/0000-0003-0118-561X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J H Beijnen', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.204, 'has_fulltext': False, 'cited_by_count': 141, 'citation_normalized_percentile': {'value': 0.908257, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '4', 'issue': '10', 'first_page': '2293', 'last_page': '7'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.47523502}], 'concepts': [{'id': 'https://openalex.org/C2777292972', 'wikidata': 'https://www.wikidata.org/wiki/Q423762', 'display_name': 'Paclitaxel', 'level': 3, 'score': 0.94286776}, {'id': 'https://openalex.org/C181389837', 'wikidata': 'https://www.wikidata.org/wiki/Q461809', 'display_name': 'Bioavailability', 'level': 2, 'score': 0.8193889}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.810089}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.7969883}, {'id': 'https://openalex.org/C2777056448', 'wikidata': 'https://www.wikidata.org/wiki/Q285166', 'display_name': 'Oral administration', 'level': 2, 'score': 0.59466}, {'id': 'https://openalex.org/C125287762', 'wikidata': 'https://www.wikidata.org/wiki/Q1758948', 'display_name': 'Absorption (acoustics)', 'level': 2, 'score': 0.5648897}, {'id': 'https://openalex.org/C97320921', 'wikidata': 'https://www.wikidata.org/wiki/Q718753', 'display_name': 'Drug interaction', 'level': 3, 'score': 0.5332596}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.5087324}, {'id': 'https://openalex.org/C76318530', 'wikidata': 'https://www.wikidata.org/wiki/Q16833590', 'display_name': 'Area under the curve', 'level': 2, 'score': 0.50459254}, {'id': 'https://openalex.org/C2778707650', 'wikidata': 'https://www.wikidata.org/wiki/Q412902', 'display_name': 'P-glycoprotein', 'level': 4, 'score': 0.47523502}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44067234}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.4041737}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39429367}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1871025}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.073919415}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.06369391}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.06316581}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C24890656', 'wikidata': 'https://www.wikidata.org/wiki/Q82811', 'display_name': 'Acoustics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020168', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D016572', 'descriptor_name': 'Cyclosporine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D020168', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000042', 'descriptor_name': 'Absorption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001682', 'descriptor_name': 'Biological Availability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016572', 'descriptor_name': 'Cyclosporine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9796957', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.82, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1859440350', 'https://openalex.org/W1905936368', 'https://openalex.org/W1964470226', 'https://openalex.org/W1965959092', 'https://openalex.org/W1983550144', 'https://openalex.org/W1984820569', 'https://openalex.org/W2005779465', 'https://openalex.org/W2028533496', 'https://openalex.org/W2033039857', 'https://openalex.org/W2037621239', 'https://openalex.org/W2047856774', 'https://openalex.org/W2066522045', 'https://openalex.org/W2087530953', 'https://openalex.org/W2099149475', 'https://openalex.org/W2102903528', 'https://openalex.org/W2121019104', 'https://openalex.org/W2133622858', 'https://openalex.org/W2137303860', 'https://openalex.org/W2166153381'], 'related_works': ['https://openalex.org/W782559034', 'https://openalex.org/W3006895202', 'https://openalex.org/W2909244384', 'https://openalex.org/W2326562699', 'https://openalex.org/W2169427225', 'https://openalex.org/W2123869439', 'https://openalex.org/W2096974984', 'https://openalex.org/W2011033998', 'https://openalex.org/W1982777678', 'https://openalex.org/W1969203961'], 'abstract_inverted_index': {'Recent': [0], 'experiments': [1], 'in': [2, 154, 178, 244], 'mice': [3, 98, 155, 179], 'have': [4], 'demonstrated': [5], 'that': [6, 222, 234, 272], 'the': [7, 20, 42, 82, 88, 143, 146, 160, 198, 206, 223, 246, 258], 'systemic': [8, 199, 247], 'exposure': [9, 200, 248], 'to': [10, 55, 142, 169, 189, 201, 249], 'p.o.': [11, 91, 202, 250], 'administered': [12, 94, 152, 203, 251], 'paclitaxel': [13, 108, 126, 153, 164, 204], 'is': [14, 53, 275], 'significantly': [15, 211], 'enhanced': [16, 224], 'with': [17, 59, 171, 181], 'coadministration': [18, 172], 'of': [19, 44, 50, 84, 90, 103, 125, 150, 163, 173, 194, 208, 260, 266, 282], 'P-glycoprotein': [21, 66], 'blocker': [22], 'SDZ': [23, 238], 'PSC': [24, 239], '833': [25, 240], '(J.': [26], 'van': [27], 'Asperen': [28], 'et': [29], 'al,': [30], 'Br.': [31], 'J.': [32], 'Cancer,': [33], '76:': [34], '1181-1183,': [35], '1997).': [36], 'To': [37], 'facilitate': [38], 'further': [39, 280], 'research': [40, 281], 'on': [41, 87, 197], 'feasibility': [43], 'a': [45, 60, 72, 78, 100, 210, 261, 276], 'clinically': [46, 262], 'effective': [47, 243], 'oral': [48, 161, 264], 'formulation': [49, 265], 'paclitaxel,': [51], 'it': [52], 'important': [54], 'know': [56], 'whether': [57], 'cotreatment': [58], 'commonly': [61], 'applied': [62], 'and': [63, 92, 214, 237, 270], 'commercially': [64], 'available': [65], 'blocker,': [67], 'e.g.,': [68], 'cyclosporin': [69, 85, 119, 158, 174, 186, 195, 235, 273], 'A,': [70, 159], 'has': [71], 'similar': [73], 'effect.': [74], 'Here,': [75], 'we': [76], 'present': [77], 'detailed': [79], 'study': [80], 'about': [81], 'effects': [83], 'A': [86, 120, 187, 196, 218, 236, 274], 'pharmacokinetics': [89], 'i.v.': [93, 110, 151], 'paclitaxel.': [95, 252], 'Female': [96], 'FVB': [97], 'received': [99], 'combined': [101], 'treatment': [102], '5': [104], 'or': [105, 111, 116, 183], '10': [106, 182], 'mg/kg': [107, 118, 185], '(either': [109], 'p.o.)': [112], 'plus': [113], '0,': [114], '10,': [115], '50': [117, 184], '(p.o.).': [121], 'The': [122, 176, 192], 'plasma': [123, 147], 'concentrations': [124], 'were': [127], 'determined': [128], 'at': [129], 'several': [130], 'time': [131], 'points': [132], 'after': [133], 'drug': [134, 269], 'administration': [135], 'using': [136], 'high-performance': [137], 'liquid': [138], 'chromatography.': [139], 'Calculated': [140], 'relative': [141], 'area': [144], 'under': [145], 'concentration-time': [148], 'curve': [149], 'treated': [156], 'without': [157], 'bioavailability': [162, 177], 'increased': [165, 216], 'from': [166], '9.3%': [167], 'up': [168], '67%': [170], 'A.': [175], 'cotreated': [180], 'appeared': [188], 'be': [190], 'similar.': [191], 'effect': [193], 'was': [205, 226], 'result': [207], 'both': [209], 'decreased': [212], 'clearance': [213], 'an': [215], 'uptake.': [217], 'histological': [219], 'examination': [220], 'revealed': [221], 'absorption': [225], 'not': [227], 'caused': [228], 'by': [229], 'gastrointestinal': [230], 'toxicity.': [231], 'We': [232], 'conclude': [233], 'are': [241, 255], 'equally': [242], 'increasing': [245], 'These': [253], 'data': [254], 'promising': [256], 'for': [257, 279], 'development': [259], 'useful': [263], 'this': [267, 283], 'cytostatic': [268], 'indicate': [271], 'suitable': [277], 'agent': [278], 'concept.': [284]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2169427225', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-07T18:27:43.211575', 'created_date': '2016-06-24'}