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[289, 1037, 1229], 'extracellular': [291], 'matrix': [292, 351], 'proteins.': [293], 'Inhibition': [294], 'occur': [300], 'at': [301, 316, 772], 'level': [303, 318], 'activator': [307, 311, 418, 563, 1363, 1450, 1643, 1666, 1690, 1733, 1765, 1854, 1906, 1942, 1966, 1996, 2021, 2103, 2188, 2213, 2270, 2302, 2329, 2717, 3080], '(by': [308], 'specific': [309, 339, 399], 'inhibitors,': [312], 'mainly': [313, 321, 1057, 1374], 'PAI-1)': [314], 'plasmin,': [320], 'α2-antiplasmin.': [323, 392], 'TPA-mediated': [324], 'activation': [326, 355], 'primarily': [329, 1207], 'dissolution': [332], 'fibrin.': [334], 'UPA': [335], 'binds': [336], 'cellular': [340, 409], 'receptor': [341], 'participate': [344], 'pericellular': [346], 'proteolysis': [347], 'via': [348, 354], 'degradation': [349], 'latent': [357, 1077], 'proteinases': [358], 'growth': [360, 1294], 'Binding': [362], 'physiological': [368, 420, 1089, 2172], 'activators': [370, 415, 748, 3147], 'results': [378, 1263], 'enhanced': [380, 457, 743, 778, 803, 841, 1094, 1101, 1218, 1265], 'activation,': [382], 'whereas': [383, 609], 'bound': [384], 'protected': [387], 'rapid': [389], 'inhibition': [390], 'regulated': [397], 'molecular': [400], 'interactions': [401], 'controlled': [408, 1325, 1424], 'synthesis': [410, 1237, 2100, 2216], 'release': [412], 'inhibitors.45The': [419], 'importance': [421], 'humans': [427], 'demonstrated': [429], 'associations': [431], 'impaired': [433, 892, 1615], 'thrombotic': [436, 474], 'events': [437, 968, 1742], 'excessive': [440], 'bleeding': [443], 'complications.': [444], 'Clinical': [445, 2403, 2431, 3018], 'epidemiological': [447, 867], 'suggested': [449], 'that': [450, 620, 871, 962, 1002, 1051, 1062, 1079, 1118, 1235, 1257, 1322, 1339, 1400], 'impairment': [451], 'activity,': [454], 'resulting': [455, 1317], 'deposition,': [459], 'significant': [462], 'contributor': [463], 'atherothrombosis.12Decreased': [468], 'occurs': [471], 'several': [473, 896, 1016], 'states,': [476], 'including': 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'types.28': [1109], 'association,': [1114], 'surprising': [1117], 'identified': [1130], 'disease.14In': [1139], 'al,3': [1145], 'reexamined': [1159], 'separate': [1161], 'clusters': [1164], 'markers': [1166, 2853], 'resistance,': [1169], 'inflammation,': [1170], 'These': [1175], 'adjustments': [1176], 'affected': [1177, 1245], 'differently.': [1186], 'Factors': [1187], 'strongly': [1193], 'affect': [1194], 'lesser': [1199], 'antigen;': [1202], 'latter': [1204], 'influenced': [1206, 1351], 'inflammation': [1209], 'mechanisms': [1215], 'linked': [1222], 'understood.': [1230], 'vitro': [1232], 'data': [1233, 1332], 'indicate': [1234], 'hepatocytes': [1242], 'could': [1243], 'insulin,': [1247], 'proinsulin,': [1248], 'lipoproteins.293031': [1251], 'Other': [1252], 'experimental': [1253], 'binding': [1258], 'Lp(a)': [1260], 'endothelium': [1262], 'expression,': [1267], 'prothrombotic': [1276], 'phenotype.32': [1278], 'production': [1280, 1939], 'adipocytes': [1284], 'response': [1289], 'cytokines': [1291], 'transforming': [1293], 'factor-β,': [1295], 'explain': [1298], 'insulin-resistant': [1304], 'patients.3334In': [1306], 'view': [1307], 'multifactorial': [1310], 'nature': [1311], 'atherothrombotic': [1313], 'for,': [1326], 'al': [1336], 'would': [1337], 'suggest': [1338], 'constitute': [1343], 'biological': [1345], 'marker': [1346], 'pathophysiological': [1356], 'pathways,': [1357], 'inflammation.': [1359], 'contrast,': [1361], 'determine': [1367], 'dependent': [1373], 'status,': [1378], 'emerge': [1379, 1431], 'future': [1387], 'atherothrombosis.': [1390, 2199], 'message': [1393], 'seems': [1397], 'because': [1401], 'markers,': [1418], 'choice': [1420], 'determines': [1427], 'disease.Selected': [1438], 'Abbreviations': [1439], 'AcronymsECAT=European': [1441], 'Concerted': [1442], 'Action': [1443], 'Thrombosis': [1445, 1487, 2650, 2911], 'DisabilitiesPAI-1=type': [1447], 'I': [1448, 2384, 2547, 2776], 'inhibitorTPA=tissue-type': [1451], 'activatorUPA=urokinase-type': [1453], 'activatorFootnotesCorrespondence': [1455], 'D.': [1457, 2169], 'Collen,': [1458], 'Campus': [1468], 'Gasthuisberg,': [1469], 'O': [1470], '&': [1471, 2404], 'N,': [1472, 1956, 2206], 'Herestraat': [1473], '49,': [1474], 'B-3000': [1475], 'E-mail': [1478], 'de´sire´[email': [1479], 'protected]': [1480], 'References': [1481], '1': [1482, 1904, 1944, 1968, 2190, 2215, 2272, 2300, 2331], 'Davies': [1483], 'MJ,': [1484, 1845], 'Thomas': [1485], 'A.': [1486], 'sudden': [1494, 1545, 1805], 'cardiac': [1495], 'ischemic': [1496], 'death.': [1497, 1719], 'N': [1498, 1812, 1834], 'Engl': [1499, 1813, 1835], 'J': [1500, 1814, 1836, 2232, 2282, 2338, 2443, 2464, 2640, 2667, 2755, 2811, 2842], 'Med.1984;': [1501], '310:1137-1140.CrossrefMedlineGoogle': [1502], 'Scholar2': [1503], 'Hamsten': [1504, 1625], 'A,': [1505, 1626, 1635, 2121, 2835, 2942, 2994, 2998], 'Eriksson': [1506], 'P.': [1507, 2184], 'Baillieres': [1511, 1585, 1599, 2174], 'Clin': [1512, 1586, 1600, 2175, 2233, 2339], 'Haematol.1995;': [1513, 1587, 1601, 2176], '8:345-363.CrossrefMedlineGoogle': [1514], 'Scholar3': [1515], 'I,': [1517, 1591, 2067, 2113, 2180, 2988], 'Pyke': [1518, 1788], 'SDM,': [1519, 1789], 'Alessi': [1520, 1592, 1959, 2181, 2207], 'M': [1521, 2387, 2440, 2461, 2705, 3038, 3106], 'C,': [1522, 1637, 2833, 3036], 'Jespersen': [1523, 1658], 'J,': [1524, 1657, 1787, 1889, 2528, 2698, 2805, 3099, 3101], 'Haverkate': [1525, 1790, 1822], 'F,': [1526, 1791, 1823, 1924, 1934, 1962, 2009, 2013, 2204, 2319, 2830], 'Thompson': [1527, 1784, 1824], 'SG,': [1528, 1785], 'Study': [1534], 'Group.': [1535], 'Fibrinolytic': [1536], 'death': [1546, 1806], 'pectoris.': [1551, 1748, 1811], 'Circulation.1996;': [1552, 2315], '94:2057-2063.CrossrefMedlineGoogle': [1553], 'Scholar4': [1554], 'D,': [1556, 2146, 2659], 'HR.': [1558], 'Basic': [1559], 'aspects': [1562], 'thrombolysis.': [1566], 'Blood.1991;': [1567], '78:3114-3124.CrossrefMedlineGoogle': [1568], 'Scholar5': [1569], 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2020, 2212, 2506, 2760, 2968, 3051], 'plasma:': [1646, 1709], 'Lancet.1987;': [1653], '2:3-9.CrossrefMedlineGoogle': [1654], 'Scholar9': [1655], 'Gram': [1656], 'selective': [1661], 'depression': [1662], 'tissue': [1664, 1763, 1851, 2335], '(t-PA)': [1667, 3053], 'euglobulins': [1670], 'characterises': [1671], 'group': [1674], 'among': [1675], 'survivors': [1676], 'Thromb': [1681, 1979, 2003, 2028, 2082], 'Haemost.1987;': [1682], '57:137-139.CrossrefMedlineGoogle': [1683], 'Scholar10': [1684], 'Cimmiello': [1685], 'C.': [1686], 'Tissue': [1687, 1731], 'type': [1688, 1852, 1903, 2105, 2249, 2299], 'Lancet.1993;': [1696, 1860], '342:48-49.CrossrefMedlineGoogle': [1697], 'Scholar11': [1698], 'Jansson': [1699, 1725, 1754, 2810], 'JH,': [1700, 1726, 1755], 'Nilsson': [1701, 1727, 1758, 2802, 2806], 'TK,': [1702, 1728, 2240, 2292], 'Johnson': [1703], 'O.': [1704], 'Von': [1705], 'novel': [1711, 2368, 2397], 'Br': [1720], 'Med': [1721], '66:351-355.Google': [1723], 'Scholar12': [1724], 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