Publication Information

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{'volume': '276', 'issue': '30', 'first_page': '28219', 'last_page': '28225'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural 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4673, 4699, 4719, 4727, 4738, 4745, 4786, 4842, 4849, 4860, 4985, 4987, 4994, 5003, 5005, 5016, 5065, 5080, 5158, 5288, 5337, 5414, 5424, 5455, 5561, 5573, 5621, 5805, 5853, 5881, 6017, 6021, 6056, 6068, 6074, 6080], 'Ras-like': [4, 191], 'proteins': [5, 15, 52, 192, 202, 239, 403, 428, 467, 498, 534, 575, 1073, 1399, 1566, 1627, 1715, 1886, 1895, 1982, 2349, 2619, 2656, 2687, 2694, 2721, 2757, 2765, 2783, 3016, 3108, 3286, 3488, 3650, 3760, 3888, 3915, 4167, 5321, 5387, 5664, 5824], 'to': [6, 16, 47, 170, 193, 203, 234, 357, 462, 564, 629, 648, 673, 697, 970, 991, 1147, 1165, 1304, 1328, 1337, 1430, 1437, 1448, 1532, 1564, 1567, 1575, 1711, 1796, 1870, 2059, 2121, 2188, 2259, 2353, 2439, 2454, 2505, 2580, 2584, 2621, 2759, 2768, 2772, 2955, 3092, 3151, 3167, 3278, 3293, 3372, 3380, 3405, 3466, 3508, 3664, 3944, 3973, 3999, 4011, 4135, 4165, 4177, 4298, 4455, 4688, 4723, 4759, 4761, 4938, 4967, 5114, 5260, 5323, 5381, 5480, 5550, 5615, 5636, 5647, 5670, 5744, 5767, 5981, 5996, 6043, 6046], 'the': [7, 24, 35, 41, 48, 56, 59, 121, 134, 139, 153, 171, 176, 184, 194, 211, 222, 228, 235, 243, 246, 308, 321, 326, 340, 358, 363, 371, 516, 569, 654, 668, 682, 685, 689, 693, 719, 730, 734, 747, 751, 865, 873, 879, 886, 935, 939, 973, 992, 1033, 1037, 1043, 1078, 1085, 1149, 1159, 1161, 1166, 1224, 1254, 1269, 1302, 1321, 1343, 1388, 1397, 1432, 1441, 1459, 1467, 1479, 1484, 1488, 1568, 1662, 1672, 1677, 1721, 1810, 1866, 1877, 1889, 1893, 1990, 2020, 2060, 2072, 2078, 2086, 2098, 2109, 2114, 2127, 2252, 2260, 2294, 2321, 2358, 2440, 2484, 2497, 2581, 2682, 2698, 2709, 2745, 2894, 2920, 2949, 2996, 3012, 3044, 3111, 3130, 3136, 3163, 3168, 3191, 3299, 3363, 3366, 3395, 3415, 3451, 3467, 3472, 3499, 3518, 3568, 3617, 3644, 3671, 3675, 3680, 3686, 3690, 3700, 3704, 3737, 3745, 3753, 3786, 3790, 3909, 3912, 3937, 3947, 3964, 3976, 4106, 4110, 4116, 4137, 4147, 4158, 4166, 4190, 4205, 4209, 4276, 4329, 4493, 4618, 4641, 4654, 4705, 4716, 4750, 4766, 4847, 4858, 4868, 4934, 4959, 4980, 5021, 5036, 5089, 5104, 5110, 5123, 5128, 5131, 5146, 5250, 5266, 5270, 5298, 5304, 5309, 5319, 5389, 5395, 5399, 5428, 5443, 5459, 5463, 5466, 5483, 5526, 5557, 5571, 5575, 5613, 5617, 5626, 5634, 5638, 5662, 5666, 5671, 5756, 5758, 5763, 5800, 5809, 5813, 5848, 5861, 5882, 6048, 6090], 'correct': [8, 195], 'subcellular': [9, 196], 'compartment': [10, 197, 2062, 5023, 5038], 'is': [11, 117, 198, 304, 429, 535, 641, 695, 718, 759, 766, 868, 968, 989, 1145, 1228, 1237, 1318, 1332, 1378, 1561, 1614, 1975, 2019, 2037, 2119, 3148, 3276, 3402, 3455, 3767, 3777, 3796, 3832, 3837, 3905, 3936, 3953, 3988, 4087, 4130, 4156, 4219, 4275, 4292, 4326, 4490, 4747, 4757, 4774, 4865, 4954, 5033, 5249, 5451, 5509, 5533, 5567, 5651, 5855], 'essential': [12, 199, 1340, 4184], 'for': [13, 84, 165, 200, 271, 352, 597, 983, 1065, 1239, 1251, 1273, 1320, 1335, 1530, 1616, 1980, 2024, 2381, 2496, 2514, 2644, 2739, 2802, 2833, 2852, 3011, 3087, 3123, 3129, 3284, 3739, 3784, 3908, 3940, 3958, 3993, 4109, 4185, 4202, 4280, 4359, 4447, 4523, 4611, 5313, 5556, 5645, 5859, 5890, 6030, 6077, 6087], 'these': [14, 98, 201, 285, 1609, 1654, 2248, 3019, 3115, 3598, 5092, 5246, 5926], 'mediate': [17, 204, 4136], 'their': [18, 45, 104, 181, 205, 232, 291, 368, 1681, 2002, 5120, 5534], 'biological': [19, 206, 530, 638], 'effects.': [20, 207], 'Many': [21, 208], 'members': [22, 209, 500, 513, 1660, 1719, 1988, 1998, 3025, 3189, 3297, 3413, 3642, 4773, 5144, 5169], 'superfamily': [26, 213, 504, 670, 1723, 3646, 6032], '(Ha-Ras,': [27, 214, 404, 1074], 'N-Ras,': [28, 215, 406, 801, 921], 'TC21,': [29, 92, 216, 279, 407, 1669, 4155, 4361, 4525, 5157], 'RhoA)': [31, 218], 'are': [32, 219, 499, 671, 806, 812, 926, 1019, 1063, 3890, 3893, 3917, 3921, 4182, 4335, 4365, 4499, 4529, 4690, 4844, 5086, 5295, 5317, 5343, 5409, 5477, 5868, 5930, 5971, 5993], 'prenylated': [33, 71, 220, 258, 386, 1154, 1692, 3176, 3457, 4071, 4220, 4845, 5115, 5344, 5437, 5548], 'in': [34, 55, 119, 138, 152, 221, 242, 306, 325, 339, 413, 433, 746, 864, 885, 972, 987, 1158, 1308, 1324, 1326, 1342, 1382, 1473, 1496, 1518, 1648, 1703, 2039, 2046, 2070, 2126, 2132, 2139, 2186, 2194, 2257, 2265, 2350, 2357, 2445, 2462, 2548, 2605, 2697, 2704, 2751, 2829, 2840, 2849, 2878, 2924, 2966, 2999, 3110, 3162, 3288, 3355, 3430, 3441, 3448, 3459, 3482, 3576, 3580, 3594, 3613, 3619, 3624, 3632, 3634, 3647, 3924, 4013, 4063, 4085, 4092, 4144, 4254, 4290, 4302, 4311, 4313, 4459, 4468, 4470, 4480, 4622, 4649, 4664, 4671, 4674, 4692, 4776, 4846, 4867, 4973, 4989, 5008, 5020, 5035, 5243, 5404, 5411, 5417, 5453, 5474, 5478, 5488, 5498, 5500, 5511, 5523, 5570, 5574, 5612, 5633, 5653, 5665, 5878, 5934, 6010, 6063], 'cytoplasm': [36, 223, 4848, 5572, 5614], 'then': [38, 225, 2500, 2521, 2882, 4850, 4861], 'transit': [39, 226, 1076, 4856], 'through': [40, 183, 227, 370, 1077, 2077, 4857, 5122, 5625], 'endomembrane': [42, 185, 229, 372, 2079, 4975, 5124, 5627], 'system': [43, 230, 5125], 'on': [44, 231, 650, 681, 1487, 1884, 2688, 2822, 2898, 2912, 2935, 3521, 3744, 4749, 5895], 'way': [46, 233, 3926], 'plasma': [49, 236, 1066, 1086, 1167, 1569, 3169, 5672, 5885], 'membrane.': [50, 237, 3170], 'The': [51, 95, 109, 238, 282, 296, 496, 529, 557, 676, 853, 1046, 1140, 1993, 2026, 2049, 2415, 2428, 2510, 2593, 2618, 2716, 2755, 2780, 2908, 2940, 3015, 3118, 3504, 4140, 4287, 4355, 4484, 4519, 4729, 4741, 4924, 5076, 5240, 5490, 5521, 5739, 5873], 'that': [53, 70, 145, 158, 240, 257, 332, 345, 514, 855, 1018, 1374, 1434, 1478, 1523, 1612, 1651, 1671, 1973, 2011, 2064, 3004, 3104, 3135, 3185, 3394, 3771, 3836, 3889, 3901, 3916, 3933, 4062, 4105, 4122, 4172, 4267, 4677, 4949, 4952, 4969, 5031, 5139, 5151, 5163, 5462, 5503, 5508, 5517, 5529, 5545, 5565, 5799, 5820, 5867, 5896], 'aid': [54, 241], 'trafficking': [57, 182, 244, 369, 523, 1141, 1162, 2073, 3164, 5121, 5624], 'small': [60, 99, 166, 177, 247, 286, 353, 364, 810, 1442, 1678, 2075, 2106, 2115, 2130, 2254, 3273, 3400, 4353, 4517, 4710, 4928, 4941, 4960, 5108, 5116, 5247, 5271, 5305, 5438, 5449, 5496, 5515, 5527, 5607, 5641, 5865, 5940, 6019, 6058], 'GTPases': [61, 100, 116, 167, 178, 248, 287, 303, 354, 365, 811, 1679, 2076, 2131, 3401, 4711, 4929, 4942, 4961, 5117, 5248, 5272, 5316, 5439, 5450, 5497, 5516, 5528, 5549, 5608, 5642, 5866, 5992, 6020], 'have': [62, 249, 576, 1023, 1372, 1521, 2084, 2202, 2952, 4008, 4780, 5029, 5161, 5817], 'not': [63, 250, 1020, 1333, 1393, 1562, 1717, 1976, 3140, 3403, 3426, 3456, 3464, 3532, 3542, 3550, 3605, 3799, 3843, 3880, 3891, 3906, 3918, 3922, 3928, 4100, 4183, 4222, 4660, 4955, 5074, 5095, 5318, 6006], 'been': [64, 251, 577, 2203, 2953, 4009, 5818, 5947], 'well': [65, 252], 'characterized.': [66, 253], 'We': [67, 156, 254, 343, 1646, 5149, 5543, 6070, 6082], 'report': [68, 255, 1650, 4372, 4536], 'here': [69, 144, 256, 331], 'Rab': [72, 85, 259, 272, 387, 1693, 1714, 1798, 1885, 1894, 1937, 1981, 3177, 3192, 3285, 3406, 5167, 5814], 'acceptor': [73, 260, 388, 1694, 3178], 'protein': [74, 124, 164, 261, 311, 351, 389, 395, 694, 940, 981, 1456, 1489, 1702, 2101, 2193, 2965, 3160, 3179, 3454, 3972, 4218, 5555, 6029], '(PRA1),': [75, 262], 'which': [76, 263, 511, 3021, 3974, 4007, 4963, 5945, 6060], 'others': [77, 264], 'previously': [78, 265], 'identified': [79, 266, 1625, 1698, 2138, 2961, 3353], 'as': [80, 161, 267, 348, 1016, 1699, 2159, 2318, 2347, 2397, 2614, 2664, 2962, 3469, 3471, 4854, 5307, 5341, 5552, 5943, 6024], 'a': [81, 268, 430, 434, 502, 538, 644, 664, 743, 977, 1024, 1057, 1170, 1221, 1248, 1305, 1379, 1463, 1494, 1620, 1700, 1977, 2068, 2123, 2140, 2145, 2189, 2287, 2455, 2535, 2615, 2913, 2925, 2936, 2963, 2967, 2972, 3121, 3154, 3159, 3280, 3356, 3431, 3652, 3665, 3970, 4014, 4123, 4198, 4303, 4460, 4481, 5506, 5856, 5902, 5983, 6025, 6041], 'prenylation-dependent': [82, 110, 269, 297, 4925], 'receptor': [83, 270, 6026], 'proteins,': [86, 273, 510, 918, 1014, 1655, 1799, 4150, 5336], 'also': [87, 274, 468, 1030, 1265, 1446, 1801, 1939, 1984, 2102, 4864, 5018, 5471, 5709, 5979], 'interacts': [88, 275, 1657, 2103, 3187, 3385, 3410, 3874, 4096, 4259, 4308, 4465, 4734, 5434, 5519, 5531], 'with': [89, 101, 114, 126, 148, 276, 288, 301, 313, 335, 1281, 1658, 1676, 1713, 1803, 1986, 1999, 2104, 2373, 2377, 2435, 2450, 2599, 2630, 2641, 2724, 2799, 2825, 2836, 2845, 2861, 2874, 2884, 2901, 3106, 3188, 3295, 3359, 3374, 3382, 3386, 3399, 3411, 3428, 3438, 3480, 3498, 3514, 3537, 3545, 3553, 3574, 3611, 3640, 3749, 3757, 3781, 3875, 3898, 3930, 3968, 4097, 4194, 4260, 4284, 4300, 4309, 4457, 4466, 4647, 4662, 4681, 4709, 4725, 4735, 4770, 4788, 4930, 4933, 4940, 4943, 4962, 5142, 5154, 5166, 5297, 5386, 5435, 5447, 5494, 5513, 5532, 5606, 5661, 5711, 5950], 'Ha-Ras,': [90, 277, 572, 692, 800, 920, 1666, 3360, 3383, 3419, 3522, 3750, 3982, 4360, 4524, 5155], 'RhoA,': [91, 278, 1667, 3389, 3420, 3476, 3523, 4362, 4526, 5156], 'Rap1a.': [94, 281, 5159], 'interaction': [96, 283, 1465, 1673, 2027, 2110, 3133, 3396, 3618, 4357, 4521, 4767, 5291, 5444, 5469], 'PRA1': [102, 113, 123, 137, 146, 159, 289, 300, 310, 324, 333, 346, 1696, 1708, 1800, 1863, 1883, 1933, 1974, 2000, 2031, 2036, 2054, 2058, 2065, 2088, 2100, 2118, 2184, 2364, 2387, 2418, 3186, 3275, 3291, 3354, 3384, 3398, 3409, 3429, 3481, 3528, 3575, 3588, 3592, 3610, 3630, 3638, 3748, 3756, 3873, 3967, 4095, 4113, 4148, 4186, 4193, 4258, 4301, 4310, 4351, 4458, 4467, 4515, 4648, 4663, 4678, 4689, 4708, 4731, 4769, 4937, 4953, 4970, 4984, 4995, 5006, 5017, 5032, 5101, 5113, 5140, 5152, 5164, 5384, 5402, 5407, 5429, 5446, 5487, 5493, 5504, 5530, 5546, 5566, 5603, 5630, 5650, 5658, 5708, 5761, 5806, 5854, 6013, 6038], 'requires': [103, 290, 1680, 2001, 2111], 'post-translational': [105, 292, 674, 1225, 1682, 2003, 3655, 3740, 3763, 3774, 4142, 4173, 4330, 4494, 4751, 5535], 'modification': [106, 293, 1491, 1572, 1683, 2004, 3741, 4143, 4752, 5324, 5536], 'by': [107, 168, 294, 355, 421, 537, 870, 1285, 1300, 1490, 1559, 1684, 1936, 2005, 2041, 2276, 2281, 2312, 2390, 2489, 2627, 2659, 2679, 2702, 2778, 2786, 3018, 3511, 3960, 4072, 5126, 5325, 5537, 5871, 6053], 'prenylation.': [108, 295, 1685, 2006, 5326], 'association': [111, 298, 1994, 3569, 3608, 3746, 3754, 3910, 3965, 4191, 4706, 4742, 4783, 4926, 5460, 5491], 'multiple': [115, 302, 1659, 2105, 3412, 3641, 4285, 5143, 5436, 5448, 5495], 'conserved': [118, 305, 744, 2124, 4775, 5452, 5473], 'evolution;': [120, 307], 'yeast': [122, 309, 804, 922, 1621, 1704, 2087, 2099, 2141, 2363, 2368, 2491, 2968, 3432, 3563, 4064, 4073, 4086, 4304, 4461, 4623, 4672, 4717, 4730], 'associates': [125, 312, 1802, 3536, 3544, 3552, 3639, 4283, 4680, 5141, 5153, 5165, 5385, 5710], 'both': [127, 314, 3954, 3989, 4131, 4736, 5412, 5569, 6015, 6054], 'Ha-Ras': [128, 149, 315, 336, 2029, 2052, 3571, 3586, 3649, 3743, 3952, 4082, 4120, 4726, 4737, 4744, 4986, 4993, 5004], 'RhoA.': [130, 317, 4728], 'Earlier': [131, 318], 'studies': [132, 319, 1371, 1520, 4779, 5028, 5067, 5280, 5285, 5292], 'reported': [133, 320, 1462, 1710], 'presence': [135, 322, 2699, 5251, 5400], 'Golgi,': [140, 327], 'we': [142, 329, 1624, 1971, 2083, 3351, 3361, 3566, 3603, 3615, 3751, 3962, 4060, 4188, 4714, 4978, 5137], 'show': [143, 330, 5150, 5564], 'co-localizes': [147, 334], 'RhoA': [151, 338, 2034, 2056, 3375, 3573, 3590, 4739, 4863, 4988, 5015], 'Golgi': [154, 341, 1081, 1150, 2061, 5001, 5022, 5037, 5069, 5576, 5635], 'compartment.': [155, 342, 4976], 'suggest': [157, 344, 1611, 2010, 4266, 5544, 5798], 'acts': [160, 347], 'an': [162, 349, 760, 1453, 2012, 2791, 3006, 3124, 3142, 3607, 3660, 3768, 3778, 3833, 4268, 4782, 4956, 4974, 5553], 'escort': [163, 350, 5554, 6028], 'binding': [169, 356, 1578, 1797, 2263, 2443, 3938, 4111, 5111], 'hydrophobic': [172, 359, 5618], 'isoprenoid': [173, 360, 2013, 3661, 4269, 5084, 5105, 5132, 5256, 5541], 'moieties': [174, 361, 4164, 5106, 5257], 'facilitates': [180, 367], 'system.': [186, 373, 2080, 5628], 'guanine': [374, 380, 593, 3083], 'nucleotide': [375, 381, 594, 1534, 3084], 'dissociation': [376, 382, 595, 1805], 'stimulator': [377], 'endoplasmic': [378, 887], 'reticulum': [379, 888], 'inhibitor': [383, 1806], '1': [384, 1807, 2572, 2740, 4369, 4533], 'glutathioneS-transferase': [385], 'son': [390], 'sevenless': [392], 'green': [393], 'fluorescent': [394], 'enhanced': [396], 'GFP': [397, 3971], 'polymerase': [398, 2282, 2291], 'chain': [399, 2283], 'reaction': [400, 2284], 'immunoprecipitation': [401], 'K-Ras,': [405], 'Ras1/2)': [409], 'regulate': [410, 469, 515], 'cell': [411, 464, 471, 474, 632, 635, 651, 1344, 2582, 6065], 'growth': [412, 6066], 'eukaryotic': [414, 2096, 2134], 'cells,': [415, 1232], 'perturbation': [417], 'signaling': [419, 658, 6049], 'pathways': [420, 627, 659, 6050], 'mutation': [422], 'constitutive': [424], 'activation': [425, 1274, 2460], 'common': [431, 4145, 4291, 5244, 5512, 5524], 'occurrence': [432], 'wide': [435], 'spectrum': [436, 677], 'human': [438, 5879], 'tumors': [439, 5880], '(1Vojtek': [440, 476, 603], 'A.B.': [441, 477, 604, 1629, 2162, 2206, 2226, 2400, 2465, 2978, 3027], 'Der': [442, 478, 605, 1585, 2235, 3807, 3851, 4235], 'C.J.': [443, 479, 606, 1586, 2236, 3808, 3852, 4046, 4236], 'J.': [444, 480, 607, 1115, 1183, 1204, 1544, 1591, 1730, 1756, 1819, 1845, 1906, 1952, 2403, 3066, 3208, 3251, 3256, 3312, 3813, 3857, 4027, 4383, 4409, 4547, 4573, 4795, 4879, 4908, 5049, 5176, 5202, 5368, 5587, 5723, 5780], 'Biol.': [445, 481, 608, 1004, 1184, 1205, 1545, 1592, 1731, 1757, 1820, 1846, 1907, 1953, 2239, 3067, 3209, 3257, 3313, 3814, 3858, 4028, 4384, 4410, 4548, 4574, 4832, 4881, 4909, 5050, 5177, 5203, 5588, 5724, 5781], 'Chem.': [446, 482, 609, 1185, 1206, 1546, 1593, 1732, 1758, 1821, 1847, 1908, 1954, 3068, 3210, 3258, 3314, 3815, 3859, 4029, 4385, 4411, 4549, 4575, 4910, 5051, 5178, 5204, 5589, 5725, 5782], '1998;': [447, 483, 610], '273:': [448, 484, 611], '19925-19928Abstract': [449, 485, 612], 'Full': [450, 452, 486, 488, 613, 615, 1100, 1102, 1130, 1132, 1210, 1212, 1550, 1597, 1599, 1638, 1736, 1738, 1762, 1764, 1825, 1827, 1851, 1853, 1912, 1914, 1958, 1960, 2171, 2215, 2474, 2987, 3036, 3072, 3074, 3214, 3216, 3262, 3264, 3318, 3320, 3819, 3821, 3863, 3865, 4033, 4051, 4389, 4391, 4415, 4417, 4553, 4555, 4579, 4581, 4810, 4812, 4914, 4916, 5055, 5057, 5182, 5184, 5208, 5210, 5593, 5595, 5698, 5700, 5729, 5731, 5786, 5788], 'Text': [451, 453, 487, 489, 614, 616, 1101, 1103, 1131, 1133, 1211, 1213, 1551, 1598, 1600, 1639, 1737, 1739, 1763, 1765, 1826, 1828, 1852, 1854, 1913, 1915, 1959, 1961, 2172, 2216, 2475, 2988, 3037, 3073, 3075, 3215, 3217, 3263, 3265, 3319, 3321, 3820, 3822, 3864, 3866, 4034, 4052, 4390, 4392, 4416, 4418, 4554, 4556, 4580, 4582, 4811, 4813, 4915, 4917, 5056, 5058, 5183, 5185, 5209, 5211, 5594, 5596, 5699, 5701, 5730, 5732, 5787, 5789], 'PDF': [454, 490, 617, 1104, 1134, 1214, 1552, 1601, 1640, 1740, 1766, 1829, 1855, 1916, 1962, 2173, 2217, 2476, 2989, 3038, 3076, 3218, 3266, 3322, 3823, 3867, 4035, 4053, 4393, 4419, 4557, 4583, 4814, 4918, 5059, 5186, 5212, 5597, 5702, 5733, 5790], 'PubMed': [455, 491, 552, 618, 712, 783, 794, 825, 848, 900, 911, 951, 962, 1008, 1105, 1135, 1189, 1215, 1363, 1412, 1423, 1511, 1553, 1602, 1641, 1741, 1767, 1789, 1830, 1856, 1917, 1963, 2174, 2218, 2243, 2477, 2673, 2990, 3039, 3077, 3219, 3241, 3267, 3323, 3345, 3719, 3730, 3824, 3868, 4036, 4054, 4247, 4394, 4420, 4442, 4558, 4584, 4606, 4815, 4836, 4885, 4919, 5060, 5187, 5213, 5235, 5355, 5372, 5598, 5703, 5734, 5791, 5919, 5966], 'Scopus': [456, 492, 553, 619, 713, 784, 795, 826, 849, 901, 912, 952, 963, 1009, 1106, 1136, 1190, 1216, 1364, 1413, 1424, 1512, 1603, 1642, 1742, 1768, 1790, 1831, 1857, 1918, 1964, 2175, 2219, 2244, 2478, 2674, 2991, 3040, 3078, 3220, 3242, 3268, 3324, 3346, 3720, 3731, 3825, 3869, 4055, 4248, 4395, 4421, 4443, 4559, 4585, 4607, 4816, 4837, 4886, 4920, 5061, 5188, 5214, 5236, 5356, 5373, 5599, 5704, 5735, 5792, 5920, 5967], '(499)': [457, 493, 620], 'Google': [458, 494, 555, 621, 715, 786, 797, 828, 851, 903, 914, 954, 965, 1011, 1108, 1138, 1192, 1218, 1366, 1415, 1426, 1514, 1554, 1605, 1644, 1744, 1770, 1792, 1833, 1859, 1920, 1966, 2177, 2221, 2246, 2409, 2480, 2676, 2993, 3042, 3080, 3222, 3244, 3270, 3326, 3348, 3722, 3733, 3827, 3871, 4037, 4057, 4250, 4397, 4423, 4445, 4561, 4587, 4609, 4818, 4839, 4888, 4922, 5063, 5190, 5216, 5238, 5358, 5375, 5601, 5706, 5737, 5794, 5845, 5922, 5969], 'Scholar).': [459, 495, 556, 622, 716, 798, 829, 852, 915, 966, 1012, 1139, 1219, 1367, 1427, 1515, 1555, 1606, 1645, 1793, 1860, 1921, 1967, 2178, 2481, 2994, 3271, 3349, 3734, 3828, 3872, 4058, 4251, 4840, 4923, 5239, 5376, 5602, 5707, 5738, 5795, 5846, 5923], 'In': [460, 568, 688, 1230, 1311, 1428, 1516, 1794, 1861, 2081, 3099, 3378, 3600, 3942, 5013, 5989], 'addition': [461, 1330, 1429, 1795, 3379, 5740, 5759], 'regulating': [463, 5860], 'proliferation,': [465, 630], 'differentiation,': [470, 631], 'death,': [472, 633], 'survival': [475], 'large': [503], 'low': [506], 'molecular': [507, 4107], 'weight': [508], 'GTP-binding': [509], 'include': [512, 3022], 'actin': [517], 'cytoskeleton': [518], '(Rho': [519], 'Rac),': [521], 'vesicle': [522, 1944, 5655], '(Rabs),': [524], 'nuclear': [526, 2190, 2456], 'transport': [527, 1090, 5646], '(Ran).': [528], 'activity': [531, 1299], 'controlled': [536], 'regulated': [539], 'GTP/GDP': [540], 'cycle': [541, 5660], '(2Bourne': [542], 'H.R.': [543], 'Sanders': [544], 'D.A.': [545, 997, 3057], 'McCormick': [546], 'F.': [547, 3249], 'Nature.': [548, 5962], '1991;': [549, 4030], '349:': [550], '117-127Crossref': [551], '(2690)': [554], 'GTP-bound,': [558], 'or': [559, 724, 728, 771, 835, 1054, 1483, 2017, 2267, 2305, 2332, 2447, 2525, 2588, 2649, 2714, 2733, 2807, 2873, 2933, 3158, 3461, 3485, 3524, 3527, 3534, 3882, 3920, 4162, 4273, 5254, 5264, 5300, 5539, 5999, 6027], 'active,': [560], 'relays': [562], 'signals': [563], 'downstream': [565, 3095], 'effector': [566, 574, 626, 1472, 3009, 3112, 3127, 3143, 4944, 4957], 'proteins.': [567, 1045, 1071, 3599, 3913, 5815], 'case': [570, 690], 'numerous': [573], 'described,': [578], 'including': [579, 919, 1253, 1279, 1665, 3196, 3418], 'serine/threonine': [580, 1286, 5338], 'kinases': [581, 587, 1256, 5339], '(c-Raf,': [582], 'A-Raf,': [583], 'B-Raf),': [585], 'lipid': [586], '(type': [588], 'I': [589, 3998], 'phosphatidylinositol': [590, 1258, 1293, 3048], '3-kinase),': [591], 'stimulators': [596], 'Ral': [598], '(Ral': [599], 'GDS1': [600], 'RGL)': [602], 'Activation': [623], 'leads': [628, 1436], 'survival.': [636], 'Which': [637], 'outcome': [639], 'predominates': [640], 'somewhat': [642], 'mystery': [645], 'but': [646, 1331, 1716, 1983, 3147, 3531, 3541, 3549, 3798, 3842, 3879, 4099, 4221], 'seems': [647], 'depend': [649], 'type': [652], 'coordinate': [655], 'integration': [656], 'activated': [660, 1454, 3769, 3779, 3834, 6051], 'and/or': [661, 1267, 4128, 4180, 4870], 'inhibited': [662], 'within': [663, 1036, 4115], 'cell.': [665], 'Members': [666], 'subject': [672, 696, 1021, 3507, 5322, 5995], 'modifications.': [675, 3775], 'modifications': [679, 3764, 4331, 4495, 4853], 'depends': [680], 'composition': [683], 'carboxyl': [686, 731, 936, 3672, 3687, 3701, 5267], 'terminus.': [687], 'prenylation,': [698, 857, 1387], 'proteolysis,': [699], 'carboxylmethylation,': [700], 'andS-acylation/palmitoylation': [701], '(3Zhang': [702, 773, 890, 941, 1402, 3709, 5345], 'F.L.': [703, 774, 891, 942, 1403, 3710, 5346], 'Casey': [704, 775, 892, 943, 1181, 1202, 1404, 3711, 5347], 'P.J.': [705, 776, 893, 944, 1182, 1203, 1405, 3712, 5348], 'Annu.': [706, 777, 818, 841, 894, 945, 1406, 3713, 5349, 5912], 'Rev.': [707, 778, 819, 842, 895, 946, 1407, 3714, 5350, 5913], 'Biochem.': [708, 779, 896, 947, 1408, 1782, 3234, 3338, 3715, 4435, 4599, 5228, 5351, 5367], '1996;': [709, 780, 897, 948, 1409, 2240, 3716, 5352], '65:': [710, 781, 898, 949, 1410, 3717, 5353], '241-269Crossref': [711, 782, 899, 950, 1411, 3718, 5354], '(1738)': [714, 785, 902, 953, 1414, 3721, 5357], 'Prenylation': [717, 867], 'covalent': [720], 'attachment': [721, 1439, 3658, 4159], 'farnesyl': [723, 1480, 2016, 3662, 4161, 4272, 5079, 5253, 5299, 5538], 'geranylgeranyl': [725, 3996, 4163, 5083, 5255, 5301, 5540, 5976], 'isoprenoids': [726], 'at': [727, 742, 1458, 2517, 2742, 4204, 5263, 5752], 'near': [729, 934, 1032, 3699, 5265], 'terminus': [732, 937, 3673, 3702, 5268], 'GTPase.': [735, 2116, 4354, 4518], 'For': [736], 'family': [738, 1997, 3024, 3193, 4772, 5168], 'members,': [739], 'prenylation': [740, 1051, 1055, 1375, 1613, 2112, 4178, 4619, 5610], 'occurs': [741, 5611], 'cysteine': [745, 3666], 'carboxyl-terminal': [748, 874, 882, 3681, 3949, 4321, 4485], 'motif': [749], 'termed': [750], 'CAAX': [752, 1034, 3791, 4015, 4117, 4215, 5277], 'box,': [753, 1035], 'where': [754], 'C': [755], 'represents': [756], 'cysteine,': [757], 'A': [758, 1368, 2608, 3583, 4004, 4212, 5392], 'aliphatic': [761], 'amino': [762, 883, 1028, 1061, 3979], 'acid,': [763], 'X': [765], 'usually': [767], 'Ser,': [768], 'Met,': [769], 'Gln,': [770], 'Leu': [772, 4203], 'Scholar,': [787, 904, 955, 1109, 1193, 1416, 1745, 1771, 1834, 2222, 3223, 3245, 3327, 3723, 4038, 4398, 4424, 4562, 4588, 4819, 4889, 5191, 5217], '4Gelb': [788, 905, 956, 1417, 3724], 'M.H.': [789, 906, 957, 1418, 3725], 'Science.': [790, 907, 958, 1419, 1507, 3726], '1997;': [791, 822, 845, 908, 959, 1186, 1420, 1733, 1822, 1955, 3069, 3211, 3315, 3727, 4386, 4550, 5179, 5916], '275:': [792, 909, 960, 1208, 1421, 1760, 1849, 1910, 3728, 4413, 4577, 4912, 5053, 5206, 5591, 5727, 5784], '1750-1751Crossref': [793, 910, 961, 1422, 3729], '(138)': [796, 913, 964, 1425, 3732], 'Whereas': [799], 'K-Ras4B,': [802, 1017, 1143], 'Ras2': [805, 1455, 1469], 'farnesylated,': [807, 3838], 'most': [808], 'other': [809, 1718, 1987, 3296], 'geranylgeranylated': [813, 836, 6018, 6057], '(5Gibbs': [814, 837, 5908], 'J.B.': [815, 838, 5909], 'Oliff': [816, 839, 5910], 'A.': [817, 840, 1359, 3053, 3055, 4243, 4821, 4878, 4907, 5418, 5838, 5911, 6085], 'Pharmacol.': [820, 843, 5914], 'Toxicol.': [821, 844, 5915], '37:': [823, 846, 5917], '143-166Crossref': [824, 847, 5918], '(308)': [827, 850, 5921], 'RhoB': [830], 'can': [831, 1864, 1924, 6061], 'be': [832, 1528, 3093, 3152, 3279, 4068, 5379, 5472, 5901, 5982], 'either': [833, 2015, 2805, 3153, 4271, 5997], 'farnesylated': [834, 3691, 3800, 3919, 3934, 6016, 6055], 'enzymes': [854], 'catalyze': [856], 'farnesyltransferase': [858, 3994, 4074, 5899, 5929], 'geranylgeranyltransferase-I': [860], 'II,': [862], 'reside': [863, 4114], 'cytoplasm.': [866], 'followed': [869, 2678, 3510], 'proteolysis': [871, 4342, 4506], 'tripeptide': [875], 'methylation': [877, 3684], 'newly': [880], 'generated': [881, 2280, 2311, 2335], 'acid': [884, 1039], '(ER)': [889], 'Some': [916, 5924], 'Ras2,': [923], 'Rac1': [925], 'further': [927, 1156, 4223], 'modified': [928, 1157, 3923, 3948, 4124, 4626, 4683], 'byS-acylation': [929], '(palmitoylation)': [930], 'cysteine(s)': [932], 'located': [933, 1031, 3667, 5262], 'S-acylation': [967, 1053], 'likely': [969, 3150], 'occur': [971], 'ER,': [974, 1160], 'since': [975], 'Erf2,': [976], 'novel': [978], 'integral': [979], 'membrane': [980, 1067, 1087, 1168, 1233, 1314, 1384, 1438, 1577, 1890, 5098, 5673, 5810, 5862, 5886], 'required': [982, 1064, 1319, 1334, 3005, 3907], 'palmitoylation': [984, 3695, 3902], 'yeast,': [988, 1474, 3460, 3614, 5416, 5433], 'localized': [990, 2191, 2457], 'ER': [993, 1079, 4859, 4869], '(6Bartels': [994], 'D.J.': [995], 'Mitchell': [996], 'Dong': [998], 'X.': [999], 'Deschenes': [1000], 'R.J.': [1001], 'Mol.': [1002, 2237, 4830], 'Cell.': [1003, 1096, 1126, 1634, 2167, 2211, 2238, 2470, 2983, 3032, 4047, 4806, 4831], '1999;': [1005, 1097, 1127, 1594, 1786, 3238, 3342, 3816, 3860, 4439, 4603, 4807, 5232], '19:': [1006], '6775-6787Crossref': [1007], '(148)': [1010], 'Other': [1013], 'such': [1015, 5340, 5942], 'toS-acylation': [1022], 'polybasic': [1025, 1058], 'stretch': [1026, 1059], 'acids,': [1029, 1062], '20-amino': [1038], 'hypervariable': [1040], 'domain': [1041, 2264, 2444, 2461, 3010, 3128, 4945], 'combination': [1047], 'two': [1049, 2298, 2325, 3289, 3697], 'signals,': [1050], 'targeting': [1068], 'N-Ras)': [1075], 'finally': [1083], 'reach': [1084], 'via': [1088], 'exocytic': [1089, 5667], 'vesicles': [1091, 4872, 5644, 5668], '(7Magee': [1092], 'T.': [1093, 1119, 1180, 1506, 1539, 4799, 5836], 'Marshall': [1094, 4045], 'C.': [1095, 1773, 3059, 3225, 3329, 4426, 4590, 4891, 5219, 5420, 5681], '98:': [1098, 1128, 4808], '9-12Abstract': [1099], '(135)': [1107], '8Choy': [1110], 'E.': [1111, 1537, 4791], 'Chiu': [1112, 4792], 'V.K.': [1113, 4793], 'Silletti': [1114, 4794], 'Feoktistov': [1116, 4796], 'M.': [1117, 1775, 1779, 3227, 3231, 3331, 3335, 4428, 4432, 4592, 4596, 4797, 4825, 5221, 5225], 'Morimoto': [1118, 4798], 'Michaelson': [1120, 4800], 'D.': [1121, 1777, 3051, 3229, 3333, 4430, 4594, 4801, 5223, 5422], 'Ivanov': [1122, 4802], 'I.E.': [1123, 4803], 'Philips': [1124, 4804], 'M.R.': [1125, 4805], '69-80Abstract': [1129, 4809], '(620)': [1137, 4817], 'however,': [1144], 'unlikely': [1146], 'involve': [1148], 'compartment;': [1151], 'rather,': [1152], 'once': [1153], 'K-Ras4B': [1164], 'involves': [1169], 'microtubule': [1171], 'network': [1172], '(9Thissen': [1173], 'J.A.': [1174, 1633, 2166, 2210, 2234, 2402, 2469, 2982, 3031, 3063], 'Gross': [1175], 'J.M.': [1176], 'Subramanian': [1177], 'K.': [1178, 4226, 5828], 'Meyer': [1179], '272:': [1187, 1734, 1823, 1956, 3070, 3212, 3316, 4387, 4551, 5180], '30362-30370Crossref': [1188], '(102)': [1191], '10Chen': [1194], 'Z.': [1195], 'Otto': [1196], 'J.C.': [1197], 'Bergo': [1198], 'M.O.': [1199], 'Young': [1200], 'S.G.': [1201, 1588, 3810, 3854], '2000;': [1207, 1759, 1848, 1909, 4412, 4576, 4833, 4911, 5052, 5205, 5369, 5590, 5695, 5726, 5783, 5963], '41251-41257Abstract': [1209], '(74)': [1217], 'As': [1220, 3578, 3622, 4090, 4252], 'consequence': [1222], 'modifications,': [1226], 'membrane-localized.': [1229], 'mammalian': [1231, 2047, 3442, 3620, 4081, 4314, 4471, 4633], 'localization': [1234, 1244, 1261, 1291, 1315, 1891, 5562, 5811, 5887], 'necessary': [1238, 3955, 3990, 4132], 'transformation': [1240], 'differentiation.': [1242], 'Membrane': [1243, 1260, 1290], 'creates': [1247], 'docking': [1249], 'site': [1250, 1306, 1461], 'effectors,': [1252], 'Raf': [1255, 1263, 3023], '3-kinase.': [1259], 'may': [1264, 1295, 1445, 1492, 1527, 1573, 1887, 1938, 2066, 3463, 4971, 5118, 5470, 5604, 5631, 5659, 5807, 5978, 6005, 6022, 6039], 'facilitate': [1266, 1940, 5119, 5623, 5637], 'enable': [1268], 'subsequent': [1270, 1389, 4176], 'events': [1271, 1391, 4175], 'needed': [1272, 1529], 'its': [1276, 1297, 1339, 1471, 2094, 4721], 'catalytic': [1277, 3045], 'activity,': [1278], 'interactions': [1280, 1500, 1942], 'phospholipids': [1282], 'phosphorylation': [1284], 'tyrosine': [1288], 'kinases.': [1289], '3-kinase': [1294, 3049], 'accelerate': [1296], 'enzymatic': [1298], 'localizing': [1301], 'enzyme': [1303], 'rich': [1307], 'substrate': [1309], 'lipids.': [1310], 'Saccharomyces': [1312], 'cerevisiae,': [1313], 'transient': [1322], 'increase': [1323], 'cAMP': [1325], 'response': [1327], 'glucose': [1329], 'fulfill': [1338], 'function': [1341, 3146, 4972, 5464, 5632, 5892], '(11Bhattacharya': [1345], 'S.': [1346, 1352, 1358, 2429, 4242, 4693, 4897, 4899, 5689, 5834], 'Chen': [1347], 'L.': [1348], 'Broach': [1349], 'J.R.': [1350], 'Powers': [1351], 'Proc.': [1353, 4237], 'Natl.': [1354, 4238], 'Acad.': [1355, 4239], 'Sci.': [1356, 2405, 4240], 'U.': [1357, 4241, 5687], '1995;': [1360, 2670, 3259], '92:': [1361], '2984-2988Crossref': [1362], '(73)': [1365], 'number': [1369], 'demonstrated': [1373, 4781], 'critical': [1380, 2021, 4277], 'determinant': [1381], 'initiating': [1383, 1431], 'attachment.': [1385], 'Without': [1386], 'processing': [1390, 4174], 'do': [1392, 3927, 5094], 'take': [1394], 'place,': [1395], 'remain': [1400], 'soluble': [1401], 'process': [1433], 'ultimately': [1435], 'GTPases,': [1443, 2107, 3195, 3274, 5109, 5941, 6059], 'farnesylation': [1444, 1460, 1524, 1558, 5998], 'contribute': [1447, 1574], 'protein-protein': [1449, 3132, 4138, 5290], 'interactions.': [1450], 'Studies': [1451], 'using': [1452, 2157, 2286, 2314, 2371, 2411, 2534, 2790, 2944, 3502, 5068], 'mutated': [1457, 3109, 4010], 'decreased': [1464], 'between': [1466, 2028, 2033], 'mutant': [1468, 3758, 3794, 4217, 5279], 'adenylyl': [1475], 'cyclase,': [1476], 'suggesting': [1477, 3932], 'moiety': [1481, 3663, 5302], 'itself': [1482, 1560], 'conformation': [1485], 'imposed': [1486], 'play': [1493, 2067, 2122], 'role': [1495, 2069, 2125, 5485, 5507], 'mediating': [1497], 'productive': [1498], 'Ras-effector': [1499], '(12Kuroda': [1501], 'Y.': [1502, 4024, 5826, 5830, 5840], 'Suzuki': [1503], 'N.': [1504], 'Kataoka': [1505], '1993;': [1508, 1635, 2168, 2212, 2406, 2471, 2984, 3033], '259:': [1509], '683-686Crossref': [1510], '(120)': [1513], 'addition,': [1517, 2082, 3100, 3601, 5014, 5990], 'vitro': [1519, 1862, 4665, 4675], 'suggested': [1522, 4966, 5893], 'SOS': [1531], 'promote': [1533], 'exchange': [1535, 3085], '(13Porfiri': [1536], 'Evans': [1538], 'Chardin': [1540], 'P.': [1541, 4874], 'Hancock': [1542, 4828], 'J.F.': [1543, 2667, 4040, 4829], '1994;': [1547], '269:': [1548], '22672-22677Abstract': [1549], 'Finally,': [1556], 'although': [1557, 5088], 'sufficient': [1563, 3957, 3992, 4134], 'target': [1565, 2023, 4279, 5312], 'membrane,': [1570], 'this': [1571, 1649, 1969, 3000, 3793, 4065, 4371, 4535, 5009, 5072, 5135, 5456], 'stable': [1576, 5097], '(23Booden': [1579, 3801, 3845], 'M.A.': [1580, 3802, 3846], 'Baker': [1581, 3803, 3847], 'T.L.': [1582, 3804, 3848], 'Solski': [1583, 3805, 3849], 'P.A.': [1584, 3806, 3850], 'Punke': [1587, 3809, 3853], 'Buss': [1589, 3811, 3855, 4233], 'J.E.': [1590, 3812, 3856, 4044, 4234], '274:': [1595, 3817, 3861], '1423-1431Abstract': [1596, 3818, 3862], '(58)': [1604, 3826, 3870], 'Taken': [1607, 4262, 4667], 'together,': [1608, 4263, 4668], 'observations': [1610, 4265, 4670, 5797], 'crucial': [1615], 'function.': [1618], 'Using': [1619], 'two-hybrid': [1622, 1705, 2142, 2969, 3357, 3433, 3564, 4305, 4356, 4462, 4520, 4624], 'screen,': [1623], 'Ha-Ras-interacting': [1626, 2964], '(14Vojtek': [1628, 2161, 2205, 2464, 2977, 3026], 'Hollenberg': [1630, 2163, 2207, 2466, 2979, 3028], 'S.M.': [1631, 2164, 2208, 2224, 2467, 2980, 3029, 4232, 4903], 'Cooper': [1632, 2165, 2209, 2233, 2401, 2468, 2981, 3030, 3062, 6086], '74:': [1636, 2169, 2213, 2472, 2985, 3034], '205-214Abstract': [1637, 2170, 2214, 2473, 2986, 3035], '(1663)': [1643, 2176, 2220, 2479, 2992, 3041], 'demonstrate': [1647, 1972, 2091, 3184, 4171, 5138], 'one': [1652, 6003], 'Rip69,': [1656], 'superfamily,': [1664, 3301, 3417], 'Rip69': [1675, 1686, 2136, 2179, 2718, 2775, 2959, 3137, 3171], 'encodes': [1687, 2180, 3172], 'residues': [1688, 2181, 3173, 3669], '20–186': [1689, 2182, 3174], 'PRA1,': [1691, 3371, 3899, 3931, 3961, 4931], 'protein.': [1695, 2736], 'was': [1697, 1709, 2137, 2365, 2388, 2420, 2433, 2487, 2612, 2747, 2776, 2960, 3116, 4630, 4712, 5750], 'Rab-interacting': [1701], 'screens,': [1706], 'interact': [1712, 3294, 3373, 3427, 3437, 3479, 3929, 4299, 4456, 4661, 4724, 4939], '(15Martincic': [1724, 1813, 1946, 3202, 3306, 4377, 4541, 5170], 'I.': [1725, 1814, 1947, 3203, 3247, 3307, 4378, 4542, 4905, 5171], 'Peralta': [1726, 1815, 1948, 3204, 3308, 4379, 4543, 5172], 'M.E.': [1727, 1816, 1949, 3205, 3309, 4380, 4544, 5173], 'Ngsee': [1728, 1754, 1817, 1843, 1904, 1950, 3206, 3310, 4381, 4407, 4545, 4571, 5047, 5174, 5200, 5585, 5721, 5778], 'J.K.': [1729, 1755, 1818, 1844, 1905, 1951, 3207, 3311, 4382, 4408, 4546, 4572, 5048, 5175, 5201, 5586, 5722, 5779], '26991-26998Abstract': [1735, 1824, 1957, 3213, 3317, 4388, 4552, 5181], '(104)': [1743, 1832, 1965, 3221, 3325, 4396, 4560, 5189], '16Hutt': [1746, 1835, 4399, 4563, 5192], 'D.M.': [1747, 1836, 1897, 4400, 4564, 5040, 5193, 5364, 5578, 5714, 5771], 'Da-Silva': [1748, 1837, 1898, 4401, 4565, 5041, 5194, 5579, 5715, 5772], 'L.F.': [1749, 1838, 1899, 4402, 4566, 5042, 5195, 5580, 5716, 5773], 'Chang': [1750, 1839, 1900, 4403, 4567, 5043, 5196, 5581, 5717, 5774], 'L.H.': [1751, 1840, 1901, 4404, 4568, 5044, 5197, 5582, 5718, 5775], 'Prosser': [1752, 1841, 1902, 4405, 4569, 5045, 5198, 5583, 5719, 5776], 'D.C.': [1753, 1842, 1903, 4406, 4570, 5046, 5199, 5584, 5720, 5777], '18511-18519Abstract': [1761, 1850, 1911, 4414, 4578, 5054, 5207, 5592, 5728, 5785], '(66)': [1769, 1858, 1919, 4422, 4586, 5062, 5215, 5600, 5736, 5793], '17Bucci': [1772, 3224, 3328, 4425, 4589, 5218], 'Chiariello': [1774, 3226, 3330, 4427, 4591, 5220], 'Lattero': [1776, 3228, 3332, 4429, 4593, 5222], 'Maiorano': [1778, 3230, 3334, 4431, 4595, 5224], 'Bruni': [1780, 3232, 3336, 4433, 4597, 5226], 'C.B.': [1781, 3233, 3337, 4434, 4598, 5227], 'Biophys.': [1783, 3235, 3339, 4436, 4600, 5229], 'Res.': [1784, 3236, 3340, 4437, 4601, 5230], 'Commun.': [1785, 3237, 3341, 4438, 4602, 5231], '258:': [1787, 3239, 3343, 4440, 4604, 5233], '657-662Crossref': [1788, 3240, 3344, 4441, 4605, 5234], '(54)': [1791, 2245, 3243, 3347, 4444, 4608, 5237], 'GDP': [1804], '(GDI1)': [1808], 'v-SNARE': [1811], 'VAMP2': [1812, 1926, 1935], 'block': [1865], 'ability': [1867, 3364, 4722, 4935, 5764], 'GDI1': [1869, 1881, 5712, 5743, 5804], 'extract': [1871, 5768], 'Rab3A': [1872, 1923, 4448, 4612, 5754, 5769], 'from': [1873, 1927, 1934, 2367, 2393, 2866, 3491, 3494, 3670, 4367, 4374, 4531, 4538, 4632, 4640, 4653, 5431, 5747, 5755], 'membranes,': [1874, 5656], 'therefore': [1876], 'opposing': [1878, 5801, 5849], 'actions': [1879, 5802], 'influence': [1888, 5808], '(16Hutt': [1896, 5039, 5577, 5713, 5770], 'Further,': [1922, 2007], 'displace': [1925], 'VAMP2-PRA1': [1928], 'complexes,': [1929], 'so': [1930, 5657, 5973], 'displacement': [1931], 'v-SNARE/t-SNARE': [1941], 'fusion': [1945, 2348, 2782, 3453, 3487], 'With': [1968, 5134], 'report,': [1970, 5136], 'specific': [1978, 3282, 3404], 'partner': [1979, 3283, 3939], 'partners': [1985], 'superfamily.': [1992, 5148, 5391], 'our': [2008, 3562, 4264, 4669, 5066], 'results': [2009, 3392], 'moiety,': [2014, 4270], 'geranylgeranyl,': [2018, 4274], 'recognition': [2022, 3959, 4278, 5311], 'PRA1.': [2025, 3180, 3538, 3546, 3941, 5314], 'observed': [2038, 4621], 'vivo': [2040, 3440, 3633, 4312, 4469, 5501], 'co-precipitation': [2042], 'experiments': [2043, 5563], 'co-localization': [2045, 2050], 'cells.': [2048, 2135, 3621, 3636, 4991], 'suggests': [2063, 3134, 4104, 4951, 5461, 5502], 'facilitating': [2071], 'cloned': [2085, 4715], 'gene': [2089], 'that,': [2092], 'like': [2093], 'higher': [2095], 'counterpart,': [2097], 'Thus,': [2117, 3637, 3886, 4765, 5442, 6034], 'predicted': [2120], 'biology': [2128], 'all': [2133, 2250, 3773, 5514], 'screen': [2143, 2970, 3001, 3358], '9.5-': [2146], '10.5-day': [2148], 'short': [2149], 'insert': [2150], 'size,': [2151], 'random': [2152], 'primed': [2153], 'mouse': [2154, 2386, 2394, 2417, 2973, 3368], 'embryo': [2155, 2974], 'library': [2156, 2976], 'LexA-Ha-RasV12': [2158], 'bait': [2160], 'fused': [2185, 2256], 'frame': [2187, 2258], 'VP16': [2192, 2458, 2693, 2720], 'pVP16.': [2195, 2384, 2715], 'pLexA-Ha-Ras': [2196], 'V12,': [2197], 'pLexA-RhoAL63,': [2198], 'pLexA-TC21,': [2199], 'pLexA-Rap1a': [2201], 'described': [2204, 2398, 2665, 3445, 5819], '18Graham': [2223], 'Vojtek': [2225, 3052], 'Huff': [2227], 'S.Y.': [2228], 'Cox': [2229, 4227], 'A.D.': [2230, 4228, 4901], 'Clark': [2231], 'G.J.': [2232], '16:': [2241], '6132-6140Crossref': [2242], 'Scholar);': [2247], 'plasmids': [2249, 2436, 2451, 2498], 'express': [2251], 'full-length': [2253, 2416, 3367], 'GTPase': [2255, 4325, 4333, 4489, 4497, 5306, 5468], 'LexA': [2261, 2441], 'DNA': [2262, 2370, 2442], 'pLexA': [2266], 'pLexA-Ade.': [2268], 'pLexA-Ha-RasV12K6': [2269], 'pLexA-Ha-RasV12': [2271], 'S181': [2272, 3830, 3877], 'S184': [2273, 3831, 3878], 'were': [2274, 2310, 2338, 2345, 2512, 2529, 2546, 2578, 2595, 2625, 2639, 2657, 2695, 2722, 2766, 2784, 2796, 2817, 2859, 2896, 2910, 2922, 2942, 3002, 3089, 3102, 3489, 3506, 3984], 'constructed': [2275], 'inserting': [2277], 'aBamHI–EcoRI': [2278], 'fragment': [2279], '(PCR)': [2285], 'Ha-RasV12': [2288, 2342, 3829, 3876], 'template,': [2289], 'Expand': [2290], '(BM),': [2292], 'following': [2295, 2322, 4343, 4507], 'forward': [2296, 2323], 'reverse': [2299, 2326, 2391], 'primers,': [2300], 'respectively:': [2301], '5′-CGGAATTCATGACGGAATATAAGCTGG-3′': [2302], '5′-CGGGATCCTCACTTCTTCTTCTTCTTCTTGAGCACACACTTGCAGCT-3′': [2304], '5′-CGGGATCCTCAGGAGAGCACACACTTGGAGCTCATGGAGCCGGGGCCAC-3′.': [2306], 'pLexA-GFP': [2307], 'pLexA-GFPCAAX': [2309], 'PCR': [2313, 2337, 2372], 'pCS2': [2315, 2809], '+': [2316, 2424, 2810, 4352, 4516], 'eGFPBglII': [2317], 'template': [2319], 'oligonucleotide': [2327, 2375, 2413], 'primers:': [2328], '5′-CGGGATCCGCACCATGGTGAGCAAGGGCGAG-3′': [2329], '5′-CGGAATTCTTGCGGCCGCAATTATCCACCGCCCTTGTACAG-3′': [2331], '5′-CGGAATTCTTGCGGCCGCAATTAGGAGAGCACACATCCACCGCCCTTGTACAG-3′.': [2333], 'Inserts': [2334], 'after': [2336, 2340, 2543, 4635, 5609], 'sequenced': [2339], 'subcloning.': [2341], 'RhoAL63': [2344], 'expressed': [2346, 4084], 'HEK293': [2351, 2532, 2637, 3495, 3595, 3635], 'cells': [2352, 2533, 2545, 2638, 2795, 2858, 2868, 2909, 3443, 3496, 3596, 4315, 4472, 4634, 5749], 'glutathione': [2354, 2622], 'S-transferase': [2355], '(GST)': [2356, 3526], 'expression': [2359, 2610, 2642, 2711, 2800], 'vector': [2360, 2611], 'pEBG-3X.': [2361], 'Full-length': [2362, 2385], 'isolated': [2366, 2389], 'genomic': [2369], 'gene-specific': [2374, 2412], 'primers': [2376], 'appropriate': [2378, 2710], 'restriction': [2379], 'sites': [2380], 'subcloning': [2382], 'into': [2383, 2422, 2531, 5643], 'transcription-PCR': [2392], 'brain': [2395], 'RNA,': [2396], '(19Vojtek': [2399], 'Cell': [2404, 4880], '105:': [2407], '777-785PubMed': [2408], 'Scholar),': [2410, 3043, 3081, 5064, 5970], 'primers.': [2414], 'cDNA': [2419, 2975], 'subcloned': [2421], 'pCS3': [2423], 'MT': [2425], 'sequenced.': [2427], 'cerevisiae': [2430], 'strain': [2431], 'L40': [2432], 'transformed': [2434], 'expressing': [2437, 2452], 'fusions': [2438, 2453], 'pLexAde': [2446], 'pLexAdeNot': [2448], 'acidic': [2459], 'pVP16': [2463], 'Transactivation': [2482], 'HIS3': [2485], 'reporter': [2486], 'assessed': [2488, 3963, 4720], 'growing': [2490], 'overnight': [2492], 'while': [2493], 'maintaining': [2494], 'selection': [2495], 'plating': [2501], '10-fold': [2502], 'serial': [2503], 'dilutions': [2504], 'YC-WHULK': [2506], 'YC-LW': [2508], 'plates.': [2509], 'plates': [2511], 'incubated': [2513, 2723, 2860, 2883], '3': [2515], 'days': [2516], '30': [2518, 2853], '°C': [2519], 'photographed.': [2522], 'GST-Ha-RasV12,': [2523, 3530], 'GST-RhoAL63,': [2524], 'GST-Rap1a': [2526, 2589, 3548], 'MT-PRA1': [2528], 'co-transfected': [2530], 'calcium': [2536], 'phosphate': [2537], 'transfection': [2538], 'protocol.': [2539], 'Approximately': [2540], '36': [2541, 2819], 'h': [2542, 2741, 2820], 'transfection,': [2544], 'lysed': [2547], 'Triton': [2549, 2560, 2600, 2660, 2752, 2838, 4636], 'IP': [2550, 2601, 2753], 'buffer': [2551, 2602], '(10': [2552], 'mm': [2553, 2563, 2570, 2573], 'HEPES,': [2554], 'pH': [2555], '7.4,': [2556], '50': [2557, 2569], 'mmNaCl,': [2558], '1%': [2559, 2567], 'X-100,': [2561], '2': [2562, 3626, 4318, 4475], 'EDTA,': [2564], '0.1%': [2565, 2837], 'β-mercaptoethanol,': [2566], 'aprotinin,': [2568], 'NaF,': [2571], 'phenylmethylsulfonyl': [2574], 'fluoride).': [2575], 'Glutathione-agarose': [2576], 'beads': [2577, 2594, 2624, 2761], 'added': [2579], 'lysates': [2583, 3492], 'purify': [2585], 'GST-Ha-Ras,': [2586], 'GST-RhoA,': [2587, 2808], 'associated': [2591, 3105, 5949], 'protein(s).': [2592], 'washed': [2596, 2748, 2877], 'three': [2597, 2749], 'times': [2598, 2750], 'suspended': [2604], 'sample': [2606], 'buffer.': [2607, 2754], 'GST': [2609, 2735, 2781, 3484, 3486, 3533, 3543, 3551], 'included': [2613], 'negative': [2616], 'control.': [2617], 'bound': [2620, 2726, 2758], 'Sepharose': [2623], 'analyzed': [2626], 'Western': [2628, 2787, 3512], 'blotting': [2629, 3513], 'anti-GST': [2631, 2792, 2875], 'anti-Myc': [2633], 'tag': [2634, 2871], 'epitope': [2635, 2870, 3519], 'antibodies.': [2636], 'transfected': [2640, 2798, 3497], 'vectors': [2643, 2801], 'GST-Ha-RasV12': [2645], 'GST,': [2647], 'pEBG3X-Ha-RasV12,': [2648], 'pEBG,': [2650], 'respectively.': [2651, 2815], 'Processed': [2652], 'unprocessed': [2654, 2685, 2730], 'GST-Ha-Ras': [2655, 2728, 2731, 2806, 4629, 4639, 4652], 'prepared': [2658, 2696, 2943, 3493, 5746], 'X-114': [2661, 4637], 'partitioning': [2662, 5284], 'essentially': [2663], '(20Hancock': [2666], 'Methods': [2668], 'Enzymol.': [2669], '255:': [2671], '60-65Crossref': [2672], '(22)': [2675], 'Scholar)': [2677, 4446, 4610], 'purification': [2680], 'processed': [2683, 2727, 4224], 'GST-Ras': [2686], 'glutathione-Sepharose': [2689, 2725, 2760], 'resin.': [2690], 'VP16-Rip69': [2691], '[35S]methionine': [2701], 'coupled': [2703], 'vitrotranscription-translation': [2705], '(TNT,': [2706], 'Promega)': [2707], 'vector,': [2712], 'pRip69': [2713], 'labeled': [2717], 'protein,': [2729, 2732, 3370, 3705, 4732], 'control': [2734], 'After': [2737, 2892], 'incubation': [2738], '4': [2743, 3668, 3978, 4256], '°C,': [2744], 'resin': [2746], 'GST-fusion': [2756], 'any': [2763, 3925], 'co-associated': [2764], 'subjected': [2767], 'SDS-PAGE': [2769, 3509], 'transferred': [2771], 'Immobilon.': [2773], '[35S]Methionine-labeled': [2774], 'detected': [2777, 2785], 'autoradiography.': [2779], 'blot': [2788], 'analysis': [2789], 'antibody.': [2793], 'COS': [2794], 'transiently': [2797], 'eGFP-PRA1': [2803], 'eGFP-PRA1,': [2811], 'pEBG-3X-Ha-RasV12,': [2812], 'pEBG-RhoAL63,': [2814], 'Cells': [2816], 'fixed': [2818], 'post-transfection': [2821], 'polylysine-coated': [2823], 'coverslips': [2824, 2895], '3.7%': [2826], 'paraformaldehyde': [2827], '(Sigma)': [2828], 'phosphate-buffered': [2830, 2841, 2850, 2879], 'saline,': [2831, 2842, 2880], 'permeabilized': [2832, 2857], '15': [2834, 5077], 'min': [2835], 'X-100': [2839], 'blocked': [2844, 5762], '10%': [2846], 'goat': [2847], 'serum': [2848], 'saline': [2851], 'min.': [2854], 'Fixed': [2855], 'monoclonal': [2862], 'hybridoma': [2863], 'supernatant': [2864], 'harvested': [2865], '9E10': [2867], '(Myc': [2869], 'antibody)': [2872], 'antisera,': [2876], 'Cy3-conjugated': [2885], 'secondary': [2886], 'antibodies': [2887, 3515], '(Jackson': [2888], 'ImmunoResearch': [2889], 'Laboratories,': [2890], 'Inc.).': [2891], 'washing,': [2893], 'mounted': [2897], 'glass': [2899], 'slides': [2900], 'Prolong': [2902], '(Molecular': [2903], 'Probes,': [2904], 'Inc.,': [2905], 'Eugene,': [2906], 'OR).': [2907], 'viewed': [2911, 2934], 'Noran': [2914], 'OZ': [2915], 'laser-scanning': [2916], 'confocal': [2917], 'microscope,': [2918], 'data': [2921, 4358, 4522, 5396], 'collected': [2923], 'UNIX-based': [2926], 'Silicon': [2927], 'Graphics': [2928], 'INDY': [2929], 'R5000': [2930], 'work': [2931], 'station': [2932], 'Nikon': [2937], 'deconvolution': [2938], 'microscope.': [2939], 'figures': [2941], 'Photoshop': [2945], '5.5': [2946], '(Adobe),': [2947], 'relative': [2950], 'intensities': [2951], 'adjusted': [2954], 'visualize': [2956], 'spatial': [2957, 4981], 'overlap.': [2958], 'Among': [2995, 3272], 'clones': [2997], 'recovered': [2998, 3103], 'those': [3003], 'intact': [3007, 3125], 'Ras-Rip': [3013], 'interaction.': [3014, 4139], 'encoded': [3017], 'isolates,': [3020], 'subunit': [3046], '(21Chantry': [3050], 'Kashishian': [3054], 'Holtzman': [3056], 'Wood': [3058], 'Gray': [3060], 'P.W.': [3061], 'Hoekstra': [3064], 'M.F.': [3065], '19236-19241Abstract': [3071], '(212)': [3079], 'factors': [3086], 'Ral,': [3088], 'subsequently': [3090], 'shown': [3091, 3579, 3623, 4091, 4253, 5030, 5162], 'direct': [3094], 'targets': [3096], 'Ras.': [3098, 4685], 'isolates': [3101], 'domain;': [3113], 'among': [3114, 4146, 5245, 5525], 'Rip69.': [3117], 'lack': [3119], 'requirement': [3122, 3738, 5883], 'Ras-Rip69': [3131], 'isolate': [3138], 'does': [3139, 3425, 3436], 'encode': [3141], 'more': [3149], 'regulator': [3155], 'involved': [3161], 'Three': [3181], 'published': [3182, 4375, 4539], 'reports': [3183, 4376, 4540], 'Rab1,': [3197], 'Rab3A,': [3198], 'Rab5,': [3199], 'Rab6': [3201], '22Janoueix-Lerosey': [3246], 'Jollivet': [3248], 'Camonis': [3250], 'Marche': [3252], 'P.N.': [3253], 'Goud': [3254], 'B.': [3255, 4895, 5683], '270:': [3260], '14801-14808Abstract': [3261], '(98)': [3269], 'thought': [3277], 'relatively': [3281], 'because,': [3287], 'reports,': [3290], 'failed': [3292], 'Ras,': [3302, 4152], 'Rho,': [3303, 4153], 'Rac': [3305], 'Because': [3350], 'had': [3352], 'investigated': [3362], 'PRA': [3369], 'TC21.': [3377, 3422], 'interacting': [3381, 4149], 'TC21': [3387], 'Fig.1.': [3390], 'These': [3391, 5796], 'indicate': [3393, 4676], 'proteins;': [3407], 'instead,': [3408], 'Although': [3423, 4452], 'Rap1a': [3424, 3435, 3478, 3525, 3612, 3628, 4296, 4307, 4364, 4453, 4464, 4528], 'experiment,': [3434], 'PRA1in': [3439], '(as': [3444], 'below': [3446], 'Fig.2).': [3449], 'Perhaps': [3450], 'LexA-Rap1a': [3452], 'efficiently': [3458, 3470], 'it': [3462, 4964, 5518], 'localize': [3465], 'nucleus': [3468], 'unprenylated': [3473], 'form.Figure': [3474], '2Ha-Ras,': [3475], 'vivo.': [3483, 3577, 3648], 'purified': [3490, 4631], 'indicated': [3500], 'constructs': [3501], 'glutathione-Sepharose.': [3503], 'pull-downs': [3505], 'directed': [3516, 6036], 'against': [3517, 6037], 'tags': [3520], '(Myc).A,': [3529], 'GST-Ha-RasV12ΔCAAX,': [3535], 'B,': [3539, 3585, 4257, 5330], 'GST-RhoAL63': [3540], 'C,': [3547, 3627], 'PRA1.View': [3554], 'Large': [3555], 'Image': [3556], 'Figure': [3557], 'ViewerDownload': [3558], '(PPT)': [3559], 'To': [3560, 3735, 4170, 4616, 4702], 'confirm': [3561, 4617, 5071], 'experiments,': [3565, 4625], 'examined': [3567, 3616, 3752, 4189], 'Fig.': [3581, 3625, 4093, 4255, 4317, 4368, 4474, 4532], '2,': [3582], 'associate': [3593, 5605], 'overexpressing': [3597], 'because': [3602, 4080, 4755], 'did': [3604, 4659], 'observe': [3606], 'co-associate': [3631], 'undergo': [3651, 4851], 'series': [3653], 'modifications:': [3656], '1)': [3657], 'protein;': [3676], '2)': [3677], 'removal': [3678], 'tripeptide;': [3682], '3)': [3683], 'group': [3688], 'cysteine;': [3692], 'and,': [3693], '4)': [3694, 5294], 'cysteines': [3698, 5261], 'Cys181': [3706], 'Cys184': [3708], 'investigate': [3736], 'missing': [3761], 'key': [3762, 5310], '(Fig.3).': [3765], 'Ha-RasV12ΔCAAX': [3766, 3881], 'lacks': [3772], 'Ha-RasV12K6': [3776, 3883], 'polylysine': [3782], 'substituted': [3783], 'Ser189,': [3785], 'last': [3787, 3977], 'residue': [3788], 'box;': [3792], 'palmitoylated': [3797, 3844, 3892], 'proteolyzed,': [3839, 4127], 'methylated': [3841, 4079], '(Fig.': [3884, 4763, 5024, 5281, 5286, 5293, 5440], '3).': [3885], 'still': [3894], 'capable': [3895], 'associating': [3897], 'indicating': [3900], 'order': [3943], 'determine': [3945, 4703, 5382], 'whether': [3946, 5383], 'tetrapeptide': [3950, 3987, 4066, 4125], 'GFP-CAAX,': [3969], 'only': [3975, 5320], 'acids': [3980], 'CVLS,': [3983], 'added.': [3985], 'This': [3986, 4102], 'transferase': [3997, 5977], 'recognize': [4000], 'prenylate': [4002], 'Protein': [4003], 'Giα,': [4006], 'end': [4012], 'sequence': [4016, 4322, 4486], '(24Goldstein': [4017], 'J.L.': [4018, 5362], 'Brown': [4019], 'M.S.': [4020], 'Stradley': [4021], 'S.J.': [4022], 'Reiss': [4023], 'Gierasch': [4025], 'L.M.': [4026], '266:': [4031], '15575-15578Abstract': [4032], '25Hancock': [4039], 'Magee': [4041], 'A.I.': [4042], 'Childs': [4043], '1989;': [4048], '57:': [4049], '1167-1177Abstract': [4050], '(1460)': [4056], 'Likewise,': [4059], 'expect': [4061], 'will': [4067, 5378], 'recognized': [4069], 'probably': [4076], 'proteolyzed': [4077], 'when': [4083], 'appropriately': [4088], 'modified.': [4089], '4,': [4094], 'GFP-CAAX': [4098], 'GFP.': [4101], 'result': [4103, 4948, 6062], 'determinants': [4108], 'box': [4118, 4216, 5278], '(farnesylated,': [4126], 'methylated)': [4129], 'sole': [4141, 4288, 5241], 'Rabs,': [4151], 'isoprenylation,': [4157], '(Table': [4168, 5273], 'I).': [4169, 5274], '(proteolysis': [4179], 'methylation)': [4181], 'binding,': [4187], 'GFP-CVYS.': [4195, 4261], 'GFP-CVYS': [4196], 'contains': [4197], 'substitution': [4199], 'Tyr': [4201], 'A2': [4206], 'position': [4207], 'CA1A2X': [4210], 'box.': [4211], 'K-Ras': [4213], 'Tyr187': [4214], '(33Kato': [4225], 'Hisaka': [4229], 'M.M.': [4230], 'Graham': [4231], '1992;': [4244, 4882], '89:': [4245], '6403-6407Crossref': [4246], '(555)': [4249], 'PRA1.Table': [4281], 'IPRA1': [4282], 'GTPases:': [4286], 'feature': [4289, 5242, 5522], 'prenylationGTPaseC-terminal': [4293], 'sequencePrenylationAAXMethylationPalmitoylationTwo-hybrid': [4294], 'interactionHa-RasDESGPGCMSCKCVLSFYYY++TC21TRKEKDKKGCHCVIFFYYY++RhoALQARRGKKKSGCLVLGYYN++Rap1APVEKKKPKKKSCLLLGYYN−1-aAlthough': [4295], 'fails': [4297, 4454], 'test,': [4306, 4463], '(see': [4316, 4473], '"Results").Rab3aQLSDQQVPPHQDCACGNYN+*Rab1KIDSTPVKSASGGCCGNNN+*The': [4320], 'each': [4324, 4332, 4488, 4496], 'shown,': [4327, 4491], 'undergoes': [4334, 4498], 'indicated.': [4336, 4500], 'F,': [4337, 4501], 'farnesylation;': [4338, 4502], 'G,': [4339, 4503], 'geranylgeranylation;': [4340, 4504], 'AAX,': [4341, 4505], 'prenylation;': [4344, 4508], 'Y,': [4345, 4509], 'yes;': [4346, 4510], 'N,': [4347, 4511], 'no.': [4348, 4512], 'Two-hybrid': [4349, 4513], 'interaction,': [4350, 4514], 'derived': [4366, 4530], 'Rab1': [4450, 4614], '(*).1-a': [4451], '"Results").': [4477], 'Open': [4478], 'table': [4479], 'new': [4482], 'tab': [4483], '(*).': [4615], 'dependence': [4620], 'unmodified': [4628], 'partitioning.': [4638], 'detergent': [4642], 'phase': [4643, 4656, 5935], '(modified': [4644], 'Ras)': [4645, 4658], 'interacted': [4646], 'vitro,': [4650], 'whereas': [4651], 'aqueous': [4655], '(unmodified': [4657], '(Fig.5).': [4666], 'preferentially': [4679], 'post-translationally': [4682], '(prenylated)': [4684], 'Sequences': [4686], 'homologous': [4687], 'present': [4691, 4866, 5034, 5410], 'cerevisiae,Schizosaccaromyces': [4694], 'pombe,': [4695], 'Arabidopsis': [4696], 'thaliana,Drosophila': [4697], 'melanogaster,': [4698, 5423], 'Caenorhabditis': [4700], 'elegans.': [4701], 'if': [4704], 'conserved,': [4713], 'homolog': [4718, 5430], 'yPRA1,': [4733, 5427], '(Fig.6).': [4740], 'yPRA1': [4746, 4762], 'dependent': [4748], 'Ha-RasΔCAAX': [4756], 'unable': [4758], 'bind': [4760], '6).': [4764, 5441], 'evolution.': [4777, 5475], 'Recent': [4778, 5027], 'Ha-': [4785, 4841], 'N-Ras': [4787, 4843], 'endomembranes': [4789], '(8Choy': [4790], '26Apolloni': [4820], 'Prior': [4822], 'I.A.': [4823], 'Lindsay': [4824], 'Parton': [4826], 'R.G.': [4827], '20:': [4834], '2475-2487Crossref': [4835], '(345)': [4838], 'additional': [4852], 'they': [4855], 'Golgi.': [4862], 'endosomal': [4871], '(27Adamson': [4873], 'Paterson': [4875], 'H.F.': [4876], 'Hall': [4877], '119:': [4883], '617-627Crossref': [4884], '(329)': [4887], '28Allal': [4890], 'Favre': [4892], 'G.': [4893], 'Couderc': [4894], 'Salicio': [4896], 'Sixou': [4898], 'Hamilton': [4900], 'Sebti': [4902], 'Lajoie-Mazenc': [4904], 'Pradines': [4906], '31001-31008Abstract': [4913], '(86)': [4921], 'together': [4932], 'mutations': [4946, 5877], '(a': [4947], 'strongly': [4950], 'interacts)': [4965], 'us': [4968], 'Therefore,': [4977, 6001], 'compared': [4979], 'distribution': [4982], 'COS1': [4990], 'Both': [4992], 'exhibit': [4996], 'perinuclear': [4997, 5010], 'staining,': [4998], 'indicative': [4999], 'localization,': [5002], 'co-localize': [5007, 5019], 'region,': [5011], 'Fig.7A.': [5012], '7': [5025], 'B).': [5026], 'markers': [5070], '(data': [5073], 'shown).': [5075], 'carbon': [5078, 5082], '20': [5081], 'groups': [5085, 5093], 'hydrophobic,': [5087], 'hydrophobicity': [5090, 5129], 'support': [5096, 6088], 'localization.': [5099], 'Since': [5100], 'specifically': [5102], 'recognizes': [5103], 'masking': [5127], 'groups.': [5133], 'Others': [5160], 'covalently': [5258], 'linked': [5259], 'Our': [5275], '3),': [5282], 'Triton-X114': [5283], '5),': [5287], 'GFP-CAAX/PRA1': [5289], 'consistent': [5296], 'being': [5308, 5932], 'Small': [5315], 'Prelamin': [5327], 'A,': [5328], 'lamin': [5329], 'γ': [5331], 'subunits': [5332], 'heterotrimeric': [5334], 'G': [5335], 'LKB1': [5342], 'Scholar,29Collins': [5359], 'S.P.': [5360], 'Reoma': [5361], 'Gamm': [5363], 'Uhler': [5365], 'M.D.': [5366], '345:': [5370], '673-680Crossref': [5371], '(180)': [5374], 'It': [5377], 'interesting': [5380], 'outside': [5388], 'search': [5393], 'bases': [5397], 'reveals': [5398], 'homologs': [5403, 5408], 'many': [5405], 'organisms.': [5406], 'budding': [5413, 5432], 'fission': [5415], 'thaliana,': [5419], 'elegans,': [5421], 'Mus': [5425], 'musculus.': [5426], 'evolution,': [5454], 'conservation': [5457], 'PRA1-small': [5467], 'Experiments': [5476], 'progress': [5479], 'genetically': [5481], 'decipher': [5482], 'physiological': [5484], 'yeast.': [5489], 'vitroand': [5499], 'has': [5505, 5946], 'held': [5510], 'with.': [5520], 'moieties.': [5542], 'binds': [5547, 6014], 'act': [5551, 6023], 'GTPases.': [5558], 'Biochemical': [5559], 'fractionation': [5560], 'found': [5568, 5652], '"solubilize"': [5616], 'prenyl': [5619], 'motifs': [5620], 'thus': [5622], 'Alternatively,': [5629], 'entry': [5639], 'cellular': [5648, 5891], 'compartments.': [5649], 'synaptic': [5654], 'out': [5669], '(30Fenster': [5674], 'S.D.': [5675], 'Chung': [5676], 'W.J.': [5677], 'Zhai': [5678], 'R.': [5679], 'Cases-Langhoff': [5680], 'Voss': [5682], 'Garner': [5684, 5692], 'A.M.': [5685], 'Kaempf': [5686], 'Kindler': [5688], 'Gundelfinger': [5690], 'E.D.': [5691], 'C.C.': [5693], 'Neuron.': [5694], '25:': [5696], '203-214Abstract': [5697], '(231)': [5705], 'recombinant': [5742], 'membranes': [5745], 'PC12': [5748], 'effective': [5751], 'removing': [5753], 'membrane;': [5757], 'GDI': [5766, 5852], 'GDIs': [5816], 'solubilize': [5821], 'membrane-associated': [5822], 'Rho': [5823], '(31Fukumoto': [5825], 'Kaibuchi': [5827], 'Hori': [5829], 'Fujioka': [5831], 'H.': [5832], 'Araki': [5833], 'Ueda': [5835], 'Kikuchi': [5837], 'Takai': [5839], 'Oncogene.': [5841], '1990;': [5842], '5:': [5843], '1321-1328PubMed': [5844], 'Possibly,': [5847], 'action': [5850], 'general': [5857], 'mechanism': [5858], 'status': [5863], 'acted': [5869], 'upon': [5870], 'GDIs.': [5872], 'prevalence': [5874], 'early': [5894], 'inhibitors': [5897, 5927, 5974, 6035], 'might': [5900], 'promising': [5903, 5984], 'class': [5904, 5985], 'cancer': [5906, 5987, 6011], 'therapeutics': [5907], 'presently': [5931], 'evaluated': [5933], 'II': [5936], 'clinical': [5937], 'trials.': [5938], 'However,': [5939], 'RhoC,': [5944], 'recently': [5948], 'promotion': [5951], 'metastasis': [5953], '(32Clark': [5954], 'E.A.': [5955], 'Golub': [5956], 'T.R.': [5957], 'Lander': [5958], 'E.S.': [5959], 'Hynes': [5960], 'R.O.': [5961], '406:': [5964], '532-535Crossref': [5965], '(1308)': [5968], 'geranylgeranylated,': [5972], 'prove': [5980, 6008], 'therapeutics.': [5988], 'some': [5991], '"switch-hitters,"': [5994], 'geranylgeranylation.': [6000], 'inhibiting': [6002], 'pathway': [6004], 'necessarily': [6007], 'efficacious': [6009], 'treatment.': [6012], 'members.': [6033], 'provide': [6040], 'means': [6042], 'pharmacologically': [6044], 'intervene': [6045], 'inhibit': [6047], 'aberrantly': [6052], 'sustained': [6064], '(tumorigenesis)': [6067], 'metastasis.': [6069], 'thank': [6071, 6083], 'Bob': [6072], 'Fuller': [6073], 'David': [6075], 'Turner': [6076], 'helpful': [6078], 'comments': [6079], 'suggestions.': [6081], 'Jonathan': [6084], 'during': [6089], 'initial': [6091], 'cloning': [6092], 'Rip69/PRA1.': [6094]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2168776160', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-07T21:46:36.247051', 'created_date': '2016-06-24'}