Publication Information

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3479, 3512, 3535, 3561, 3775, 3946, 3983, 3998, 4056, 4071, 4084, 4153, 4355, 4422], 'type': [2, 44, 135, 219, 261, 352, 446, 867], '3': [3, 45, 136, 220, 262, 353, 447, 868, 1745, 2175, 2408, 3751], 'repeats': [4, 46, 137, 221, 263, 354, 870, 1360, 1404, 2012, 3758, 4020], 'of': [5, 97, 111, 127, 133, 143, 198, 222, 314, 328, 344, 350, 360, 415, 486, 508, 520, 530, 562, 572, 625, 1168, 1235, 1321, 1343, 1366, 1398, 1413, 1421, 1439, 1581, 1743, 1757, 1772, 1801, 1831, 1990, 2072, 2116, 2131, 2208, 2243, 2250, 2319, 2378, 2410, 2441, 2451, 2477, 2518, 2586, 2616, 2628, 2643, 2824, 2927, 2957, 2982, 2992, 3064, 3104, 3117, 3131, 3155, 3187, 3193, 3202, 3224, 3230, 3245, 3284, 3294, 3297, 3309, 3318, 3395, 3404, 3442, 3454, 3474, 3486, 3491, 3518, 3545, 3551, 3558, 3588, 3610, 3667, 3684, 3696, 3772, 3782, 3804, 3806, 3812, 3822, 3828, 3832, 3852, 4074, 4130, 4132, 4362, 4438, 4469, 4475, 4482, 4522, 4567], 'cartilage': [6, 223, 438, 628, 1832], 'oligomeric': [7, 224, 439, 629], 'matrix': [8, 225, 440, 630, 2991], 'protein': [9, 226, 441, 631, 722, 3475, 3559, 3674, 3726], '(COMP)': [10, 227, 632], 'cause': [11, 228, 634, 1217, 1741, 1995], 'two': [12, 229, 481, 1238, 3779, 4054], 'skeletal': [13, 230], 'dysplasias,': [14, 231], 'pseudoachondroplasia': [15, 232, 434], '(PSACH)': [16, 233], 'and': [17, 30, 54, 57, 76, 113, 125, 140, 151, 159, 172, 182, 184, 202, 234, 247, 271, 274, 293, 330, 342, 357, 368, 376, 389, 399, 401, 419, 475, 506, 550, 566, 615, 618, 637, 717, 871, 882, 1016, 1029, 1064, 1173, 1411, 1423, 1431, 1433, 1450, 1454, 1570, 1578, 1749, 1779, 1799, 1833, 1882, 1915, 1997, 2003, 2018, 2054, 2123, 2161, 2177, 2181, 2194, 2212, 2268, 2281, 2299, 2327, 2343, 2354, 2363, 2368, 2422, 2455, 2469, 2479, 2513, 2548, 2556, 2605, 2614, 2648, 2666, 2805, 2876, 2918, 2932, 2945, 2952, 2976, 2979, 2986, 3045, 3069, 3183, 3189, 3242, 3275, 3307, 3379, 3399, 3433, 3496, 3510, 3576, 3590, 3635, 3647, 3676, 3747, 3749, 3752, 3767, 3809, 3815, 3868, 3875, 3908, 3911, 3939, 3948, 3981, 4009, 4037, 4155, 4386, 4405, 4441, 4466, 4569], 'multiple': [18, 235, 435, 476], 'epiphyseal': [19, 236, 436, 477], 'dysplasia': [20, 237, 437, 478], '(MED).': [21, 238], 'We': [22, 239, 2027, 3688, 3989], 'expressed': [23, 240, 3990], 'recombinant': [24, 66, 241, 283, 451, 2001, 2442, 3370, 4337], 'wild-type': [25, 242, 2931, 2944, 2975, 3907], 'COMP': [26, 35, 69, 80, 166, 243, 252, 286, 297, 383, 453, 467, 707, 876, 941, 1011, 1169, 1211, 1326, 1562, 1993, 2002, 2032, 2048, 2080, 2091, 2140, 2885, 2934, 2947, 2978, 3459, 3910, 4154, 4431, 4471, 4476], 'that': [27, 116, 244, 333, 633, 1354, 1395, 1574, 1775, 1868, 1916, 1994, 2009, 2019, 2030, 2047, 2055, 2306, 4390, 4504, 4505], 'showed': [28, 245, 4492], 'structural': [29, 246, 1181, 1829], 'functional': [31, 248], 'properties': [32, 249], 'identical': [33, 250], 'to': [34, 149, 156, 165, 178, 195, 251, 366, 373, 382, 395, 412, 491, 606, 719, 1013, 1170, 1216, 1435, 1751, 1836, 2007, 2036, 2038, 2051, 2065, 2149, 2246, 2302, 2349, 2424, 2473, 2491, 2530, 2592, 2745, 2970, 2988, 3078, 3097, 3115, 3206, 3237, 3835, 3843, 3889, 3893, 3927, 4003, 4076, 4344, 4348, 4428, 4445, 4558], 'isolated': [36, 253, 468, 2658, 2671], 'from': [37, 254, 469, 714, 937, 2453, 2652, 2662, 2672, 3506, 3615, 3645, 4093], 'cartilage.': [38, 255], 'A': [39, 65, 256, 282, 796, 2273, 3051, 3101, 4332, 4379], 'fragment': [40, 257], 'encompassing': [41, 258, 863, 1357, 4027, 4041], 'the': [42, 93, 108, 117, 123, 130, 134, 141, 176, 196, 199, 259, 310, 325, 334, 340, 347, 351, 358, 393, 413, 416, 521, 559, 563, 569, 573, 623, 720, 800, 804, 1210, 1330, 1339, 1344, 1355, 1358, 1364, 1396, 1402, 1407, 1418, 1440, 1443, 1568, 1571, 1576, 1769, 1777, 1783, 1988, 2010, 2025, 2062, 2070, 2079, 2126, 2132, 2142, 2182, 2209, 2215, 2240, 2244, 2247, 2251, 2255, 2290, 2310, 2317, 2445, 2523, 2580, 2587, 2641, 2644, 2770, 2790, 2822, 2847, 2865, 2928, 2958, 2972, 2989, 2993, 3118, 3124, 3144, 3174, 3185, 3194, 3200, 3207, 3222, 3239, 3243, 3271, 3278, 3282, 3292, 3310, 3326, 3393, 3401, 3429, 3436, 3440, 3533, 3543, 3546, 3549, 3556, 3562, 3571, 3574, 3577, 3586, 3616, 3631, 3648, 3665, 3672, 3681, 3694, 3725, 3755, 3764, 3802, 3807, 3816, 3819, 3823, 3829, 3836, 3840, 3847, 3864, 3871, 3879, 3891, 3894, 4017, 4028, 4033, 4043, 4057, 4067, 4072, 4133, 4148, 4336, 4346, 4356, 4391, 4399, 4402, 4406, 4419, 4423, 4430, 4434, 4451, 4459, 4479, 4509, 4518], 'eight': [43, 260, 864, 4034, 4044], 'binds': [47, 164, 264, 381, 2050], '14': [48, 265], 'calcium': [49, 145, 266, 362, 1368, 1408, 2016, 2020, 3456, 3520, 3552, 3566, 3579, 3651, 3668], 'ions': [50, 146, 267, 363, 1369, 3457, 3521], 'with': [51, 167, 268, 384, 496, 556, 1175, 1754, 1874, 2041, 2060, 2152, 2157, 2173, 2190, 2205, 2278, 2296, 2324, 2331, 2366, 2407, 2418, 2432, 2464, 2515, 2623, 2736, 2756, 2777, 2800, 2852, 2870, 2954, 3173, 3268, 3346, 3426, 3530, 3663, 3798, 3897, 3936, 3951, 4088, 4443, 4472], 'moderate': [52, 269, 492], 'affinity': [53, 270, 1177], 'high': [55, 168, 272, 385, 1176], 'cooperativity': [56, 273, 3845], 'presumably': [58, 275], 'forms': [59, 276, 485, 617], 'one': [60, 277, 1236, 4131, 4444, 4483], 'large': [61, 278, 4086], 'disulfide-bonded': [62, 279], 'folding': [63, 124, 280, 341], 'unit.': [64, 281], 'PSACH': [67, 171, 284, 388, 557, 636, 1218, 1422, 1996, 4158], 'mutant': [68, 79, 285, 296, 2933, 2946, 2977, 3756, 3909], 'which': [71, 82, 288, 299, 1213, 2943, 3123], 'Asp-469': [72, 289], 'was': [73, 84, 147, 290, 301, 364, 609, 619, 1352, 1393, 1834, 2112, 2146, 2171, 2188, 2261, 2276, 2307, 2314, 2447, 2461, 2489, 2590, 2678, 2687, 2828, 2850, 2920, 2968, 2997, 3054, 3059, 3107, 3113, 3197, 3257, 3323, 3344, 3363, 3417, 3461, 3481, 3523, 3568, 3613, 3887, 3925, 3933, 4014, 4081, 4127, 4353, 4384, 4485], 'deleted': [74, 291], '(D469Δ)': [75, 292], 'a': [77, 294, 552, 709, 808, 861, 872, 1022, 1224, 1229, 1436, 1548, 1828, 1838, 1875, 1879, 2066, 2113, 2293, 2338, 2344, 2475, 2492, 2516, 2564, 2568, 2599, 2837, 2881, 3128, 3151, 3162, 3225, 3347, 3513, 3737, 3776, 3984, 3999, 4024, 4038, 4085, 4128, 4360, 4414, 4467, 4473, 4493, 4559], 'MED': [78, 173, 206, 295, 390, 423, 567, 638, 1424, 1545, 4094], 'Asp-361': [83, 300, 4075], 'substituted': [85, 302], 'by': [86, 211, 303, 428, 489, 517, 622, 854, 1559, 1565, 2024, 2061, 2263, 2360, 2383, 2449, 2560, 2621, 2907, 3291, 3302, 3463, 3788, 3826, 3858, 3904, 4554], 'Tyr': [87, 304, 4077], '(D361Y)': [88, 305], 'were': [89, 138, 306, 355, 1445, 2200, 2358, 2381, 2405, 2416, 2528, 2558, 2607, 2619, 2650, 2731, 2772, 2792, 2816, 2868, 2878, 2935, 2948, 3076, 3137, 3148, 3171, 3219, 3235, 3247, 3289, 3376, 3383, 3447, 3504, 3583, 3643, 3729, 3915, 3969, 4047, 4373], 'both': [90, 307, 613, 635, 1747, 3538], 'secreted': [91, 308, 710], 'into': [92, 309, 2214, 2309, 2372, 2444, 4339], 'cell': [94, 311, 3154, 4340], 'culture': [95, 312, 943, 2459, 4341, 4357, 4424], 'medium': [96, 313, 2446, 2460, 2488, 4358, 4425], 'human': [98, 315, 2399], 'cells.': [99, 316, 2457], 'Circular': [100, 317], 'dichroism': [101, 318], 'spectroscopy': [102, 319], 'revealed': [103, 320, 4389], 'only': [104, 321, 1447, 1558, 3736, 4042], 'small': [105, 322, 1230, 3295], 'changes': [106, 323], 'secondary': [109, 326], 'structures': [110, 327], 'D469Δ': [112, 329, 2355, 2806, 2987], 'D361Y,': [114, 331, 2804, 2875, 2985, 3044], 'demonstrating': [115, 332], 'mutations': [118, 174, 212, 335, 391, 429, 626, 1208, 1324, 1335, 1345, 1397, 1560, 1566, 1740, 1764, 1991, 2063, 2336, 4055], 'do': [119, 336], 'not': [120, 337, 1164, 1451, 1557, 4411], 'dramatically': [121, 338], 'affect': [122, 339, 1327, 1346], 'stability': [126, 343, 1412], 'COMP.': [128, 345, 1414, 4060, 4511], 'However,': [129, 346, 1442], 'local': [131, 348], 'conformations': [132, 349], 'disturbed,': [139, 356], 'number': [142, 359, 3453, 3517, 3550, 3557, 3666, 3695], 'bound': [144, 361, 3455, 3519, 3578], 'reduced': [148, 365], '10': [150, 367, 2778, 3134, 3746, 3753], '8,': [152, 369], 'respectively.': [153, 370, 3638], 'In': [154, 371, 2844], 'addition': [155, 372, 3186, 3201, 3293, 3403], 'collagen': [157, 161, 214, 374, 378, 431, 1429, 1582, 1773, 1786, 1842, 1872, 1919, 2052, 2082, 2667, 2677, 2685, 2838, 3065, 3070], 'I': [158, 375, 1172, 2647, 2655, 3066], 'II,': [160, 181, 377, 398], 'IX': [162, 183, 215, 379, 400, 432, 1774, 1787, 1826, 1920, 2053, 2083, 2686, 3071], 'also': [163, 208, 380, 425, 1546, 1564, 2028, 2049, 4374], 'affinity.': [169, 386, 2825], 'The': [170, 387, 511, 1166, 1739, 1866, 2045, 2085, 2136, 2165, 2197, 2413, 2584, 2612, 2814, 2961, 3026, 3074, 3249, 3408, 3452, 3516, 3564, 3608, 3639, 3770, 3882, 3931, 3967, 4061, 4124, 4455], 'reduce': [175, 392], 'binding': [177, 394, 1167, 1365, 2017, 2021, 2057, 2729, 2827, 2849, 3669, 3685, 3698, 3783, 3813, 3833, 3853], 'collagens': [179, 396, 1171, 2737, 3075, 3912], 'I,': [180, 397], 'result': [185, 402, 1221], 'an': [187, 404, 1233, 2634], 'altered': [188, 405, 2042], 'zinc': [189, 406, 2043, 2860, 3093], 'dependence.': [190, 407, 2044], 'These': [191, 408, 2285], 'interactions': [192, 409], 'may': [193, 203, 410, 420, 1405], 'contribute': [194, 411], 'development': [197, 414, 2071], 'patient': [200, 417, 1425], 'phenotypes': [201, 418, 2073], 'explain': [204, 421], 'why': [205, 422], 'can': [207, 424, 1019, 3785], 'be': [209, 426, 3786, 4463], 'caused': [210, 427, 516, 1556], 'genes.': [216, 433], 'epidermal': [442, 856], 'growth': [443, 857], 'factor': [444, 858], 'thrombospondin': [445, 721, 866, 4018], 'polymerase': [448], 'chain': [449, 1771], 'reaction': [450, 2275], 'full-length': [452, 2090, 4510], 'polyacrylamide': [454], 'gel': [455, 2531], 'electrophoresis': [456], 'Tris-buffered': [457], 'saline': [458], '(50': [459], 'mm': [460, 465, 2466, 2471, 2503, 2509, 2520, 2542, 2545, 2550, 2594, 2762, 2767, 2812, 3080, 3085, 3092, 3157, 3204, 3397, 3406], 'Tris,': [461, 2763], 'pH': [462, 2476, 2511, 2552, 2596, 2764, 3082, 3922], '7.4,': [463, 2597, 2765, 3083], '150': [464, 2766, 3084, 3472, 3484], 'NaCl)': [466], 'tissue': [470, 939], 'endoplasmic': [471, 1419], 'reticulum': [472, 1420], 'Pseudoachondroplasia': [473], '(PSACH)1': [474], '(MED)': [479], 'constitute': [480], 'autosomal': [482], 'dominantly': [483], 'inherited': [484], 'osteochondrodysplasias': [487], 'characterized': [488], 'severe': [490, 560, 616, 4157], 'short': [493], 'limb': [494], 'dwarfism': [495, 1881], 'normal': [497], 'skull.': [498], 'Their': [499], 'clinical': [500, 513, 548], 'features': [501], 'include': [502], 'pronounced': [503], 'joint': [504, 509], 'laxity': [505], 'limitation': [507], 'movement.': [510], 'major': [512], 'complication': [514], 'is': [515, 708, 852, 877, 1163, 1361, 1555, 1827, 2022, 2033, 2058, 3856, 4147, 4426], 'premature': [518, 1313], 'osteoarthritis': [519, 1030, 1883, 1923], 'weight-bearing': [522], 'joints': [523], '(1International': [524], 'Working': [525], 'Group': [526], 'on': [527, 2533, 2563, 2598, 2633, 3221, 3740, 3763, 3977, 4066], 'Constitutional': [528], 'Diseases': [529], 'Bone': [531], 'Am.': [532, 583, 1533, 1631, 1663, 1727, 4292], 'J.': [533, 584, 596, 660, 744, 761, 764, 784, 817, 820, 841, 904, 984, 1036, 1054, 1099, 1124, 1191, 1262, 1374, 1479, 1515, 1534, 1622, 1632, 1651, 1655, 1664, 1716, 1728, 1813, 1854, 1889, 1929, 1967, 2100, 2709, 2712, 2896, 3010, 3335, 3708, 3954, 4096, 4180, 4254, 4293, 4534, 4537], 'Med.': [534, 585, 1535, 1729, 4294], 'Genet.': [535, 586, 662, 698, 1264, 1300, 1536, 1604, 1634, 1666, 1730, 4182, 4218, 4295, 4323], '1998;': [536, 986, 1002, 1152, 1194, 3013, 4115, 4273, 4296, 4324], '79:': [537], '376-382Crossref': [538], 'PubMed': [539, 590, 666, 702, 753, 773, 793, 829, 846, 913, 931, 962, 989, 1005, 1041, 1059, 1081, 1105, 1129, 1155, 1202, 1268, 1304, 1385, 1490, 1520, 1540, 1608, 1643, 1675, 1710, 1734, 1820, 1863, 1910, 1950, 1978, 2109, 2232, 2723, 2901, 3021, 3603, 3719, 3962, 4119, 4186, 4222, 4249, 4277, 4299, 4327, 4546], 'Scopus': [540, 591, 667, 703, 847, 932, 963, 990, 1006, 1042, 1060, 1082, 1106, 1130, 1156, 1203, 1269, 1305, 1386, 1491, 1521, 1541, 1609, 1644, 1676, 1711, 1735, 1821, 1911, 1951, 1979, 2233, 2724, 2902, 3022, 3604, 3720, 3963, 4120, 4187, 4223, 4250, 4278, 4300, 4328], '(84)': [541], 'Google': [542, 593, 602, 669, 705, 754, 774, 794, 830, 849, 914, 934, 965, 992, 1008, 1044, 1062, 1084, 1108, 1132, 1158, 1205, 1271, 1307, 1388, 1493, 1506, 1523, 1543, 1611, 1646, 1678, 1713, 1737, 1823, 1864, 1913, 1953, 1981, 2110, 2235, 2726, 2904, 3024, 3341, 3606, 3722, 3965, 4122, 4189, 4225, 4252, 4280, 4302, 4330, 4547], 'Scholar).': [543, 603, 706, 795, 850, 935, 1009, 1206, 1389, 1544, 1738, 1824, 1865, 2727, 3025, 3342, 3607, 3723, 3966, 4123, 4331], 'Both': [544], 'syndromes': [545], 'exhibit': [546], 'considerable': [547], 'heterogeneity': [549], 'show': [551, 2029], 'broad': [553], 'phenotypical': [554], 'overlap': [555], 'at': [558, 568, 799, 2609, 2751, 2785, 2797, 2818, 2861, 2922, 3061, 3167, 3254, 3273, 3313, 3358, 3365, 3414, 3431, 3633, 4369, 4381, 4394, 4496], 'end': [561, 571, 2242, 2249], 'disease': [564, 574], 'spectrum': [565, 575], 'mild': [570, 614, 1880], '(2Langer': [576], 'Jr.,': [577], 'L.O.': [578], 'Schaefer': [579], 'G.B.': [580], 'Wadsworth': [581], 'D.T.': [582], '1993;': [587, 1537, 1907], '47:': [588], '772-781Crossref': [589], '(18)': [592], 'Scholar,': [594, 670, 755, 775, 831, 966, 993, 1085, 1109, 1133, 1272, 1308, 1494, 1507, 1524, 1612, 1647, 1679, 1714, 1809, 1954, 4190, 4226, 4281, 4303], '3Spranger': [595], 'Clin.': [597], 'Orthop.': [598, 1100], '1976;': [599], ':': [600], '46-59PubMed': [601], 'Genetic': [604], 'linkage': [605], 'chromosome': [607], '19': [608], 'recently': [610], 'demonstrated': [611], 'for': [612, 1180, 1363, 1746, 1768, 2015, 2069, 2089, 2128, 2139, 2254, 2292, 2774, 2794, 2821, 2830, 3033, 3038, 3043, 3049, 3139, 3304, 3368, 3620, 3693, 3702, 3754, 4059, 4527], 'soon': [620], 'followed': [621, 853, 2906, 3301], 'identification': [624], '(4Hecht': [639, 1241, 4159], 'J.T.': [640, 1242, 1478, 4160, 4291], 'Nelson': [641, 1243, 4161], 'L.D.': [642, 1244, 4162], 'Crowder': [643, 1245, 4163], 'E.': [644, 725, 735, 885, 895, 1092, 1246, 1895, 1958, 2220, 2705, 4164], 'Wang': [645, 1247, 4165], 'Y.': [646, 737, 897, 1248, 1586, 1893, 1933, 4166, 4243, 4317, 4321], 'Elder': [647, 1249, 4167], 'F.F.': [648, 1250, 4168], 'Harrison': [649, 1251, 4169], 'W.R.': [650, 1252, 4170, 4236], 'Francomano': [651, 1253, 4171], 'C.A.': [652, 1254, 1689, 4172], 'Prange': [653, 1255, 4173], 'C.K.': [654, 1256, 4174], 'Lennon': [655, 1257, 4175], 'G.G.': [656, 1258, 4176], 'Deere': [657, 1259, 4177], 'M.': [658, 733, 739, 757, 763, 813, 819, 893, 899, 925, 954, 970, 1098, 1111, 1115, 1137, 1188, 1260, 1593, 1658, 1791, 1847, 2695, 2699, 2701, 2890, 2894, 3007, 4178, 4283, 4315, 4530, 4536], 'Lawler': [659, 1261, 4179], 'Nat.': [661, 697, 1263, 1299, 1603, 4181, 4217], '1995;': [663, 699, 1265, 1301, 1377, 3711, 4183, 4219], '10:': [664, 700, 1266, 1302, 4184, 4220], '325-329Crossref': [665, 1267, 4185], '(315)': [668, 1270, 4188], '5Briggs': [671, 1273, 4191], 'M.D.': [672, 1274, 1472, 1630, 4102, 4192, 4230, 4260], 'Hoffman': [673, 1275, 4193], 'S.M.': [674, 1276, 4194], 'King': [675, 1277, 4195, 4231], 'L.M.': [676, 1278, 1699, 4196, 4232], 'Olsen': [677, 1279, 1599, 1890, 1936, 4197], 'A.S.': [678, 1280, 4198], 'Mohrenweiser': [679, 1281, 4199], 'H.': [680, 1096, 1141, 1186, 1282, 3005, 3956, 4200, 4307], 'Leroy': [681, 1283, 4201], 'J.G.': [682, 1284, 4202], 'Mortier': [683, 1285, 1617, 4203], 'G.R.': [684, 1286, 1618, 4204], 'Rimoin': [685, 1287, 4205, 4233], 'D.L.': [686, 1288, 4206, 4234], 'Lachman': [687, 1289, 4207, 4237], 'R.S.': [688, 1290, 4208, 4238], 'Gaines': [689, 1291, 4209], 'E.S.': [690, 950, 1292, 4210], 'Ceklluiak': [691, 1293, 4211], 'J.A.': [692, 1294, 1496, 1628, 4212], 'Knowlton': [693, 1295, 4107, 4213, 4239, 4265], 'R.G.': [694, 1296, 4108, 4214, 4240, 4266], 'Cohn': [695, 1297, 4109, 4215, 4267], 'D.H.': [696, 1298, 4110, 4216, 4228, 4268], '330-336Crossref': [701, 1303, 4221], '(431)': [704, 1306, 4224], 'pentameric': [711, 4452, 4470, 4520], 'glycoprotein': [712], 'built': [713], 'modular': [715], 'units': [716, 3032, 3037, 3042, 3048, 3136], 'belongs': [718], 'family': [723, 4087], '(6Hedbom': [724, 884], 'Antonsson': [726, 778, 886, 2094], 'P.': [727, 779, 887, 1511, 1532, 1614, 1649, 1718, 1845, 1966, 2095, 2222], 'Hjerpe': [728, 888], 'A.': [729, 741, 777, 889, 901, 1050, 1624, 1706, 1906, 1946, 1962, 2093, 4104, 4262, 4313], 'Aeschlimann': [730, 890], 'D.': [731, 743, 759, 783, 815, 891, 903, 921, 1034, 1190, 2099, 3009, 4532], 'Paulsson': [732, 762, 818, 892, 924, 1097, 1114, 2893, 4535], 'Rosa-Pimentel': [734, 894], 'Sommarin': [736, 896], 'Wendel': [738, 898], 'Oldberg': [740, 900, 2118], 'Heinegård': [742, 758, 782, 814, 902, 1033, 1073, 1189, 2098, 3008, 4531], 'Biol.': [745, 765, 785, 821, 905, 1192, 1375, 1480, 1816, 1855, 1968, 2101, 2713, 3011, 3337, 3709, 4538], 'Chem.': [746, 766, 786, 822, 906, 1193, 1376, 1481, 1856, 1969, 2102, 2714, 3012, 3710, 4539], '1992;': [747, 767, 787, 823, 907, 1038, 1056, 2103, 4540], '267:': [748, 768, 788, 824, 908, 2104, 4541], '6132-6136Abstract': [749, 909], 'Full': [750, 770, 790, 826, 910, 1197, 1199, 1380, 1382, 1485, 1487, 1638, 1640, 1670, 1672, 1860, 1973, 1975, 2106, 2718, 2720, 3016, 3018, 3714, 3716, 4543], 'Text': [751, 771, 791, 827, 911, 1198, 1200, 1381, 1383, 1486, 1488, 1639, 1641, 1671, 1673, 1861, 1974, 1976, 2107, 2719, 2721, 3017, 3019, 3715, 3717, 4544], 'PDF': [752, 772, 792, 828, 912, 1201, 1384, 1489, 1642, 1674, 1862, 1977, 2108, 2722, 3020, 3718, 4545], '7Mörgelin': [756], 'Engel': [760, 816, 840, 2708, 4533], '6137-6141Abstract': [769, 825, 4542], '8Oldberg': [776], 'Lindblom': [780, 2096], 'K.': [781, 1046, 1048, 1184, 1885, 1887, 1897, 2097, 2892, 3003, 4289], '22346-22350Abstract': [789, 2105], 'coiled-coil': [797, 4403, 4453], 'domain': [798, 4031, 4404, 4409, 4562], 'amino': [801, 1226, 1239, 1759, 4068, 4395], 'terminus': [802], 'mediates': [803], 'pentamerization': [805], 'resulting': [806], 'bouquet-shaped': [809], 'subunit': [810, 4484], 'arrangement': [811], '(7Mörgelin': [812, 4529], '9Malashkevich': [832], 'V.N.': [833], 'Kammerer': [834], 'R.A.': [835], 'Efimov': [836], 'V.P.': [837], 'Schulthess': [838, 2702], 'T.': [839, 1032, 1052, 1072, 1899, 1931, 2693, 2703, 4285, 4319], 'Science.': [842], '1996;': [843, 1102, 1605, 4246], '274:': [844, 2716], '761-765Crossref': [845], '(271)': [848], 'It': [851], 'four': [855], '(EGF)-like': [859], 'domains,': [860], 'region': [862, 1356, 3147], 'so-called': [865], '(T3)': [869], 'carboxyl-terminal': [873, 1340, 4436, 4480], 'globular': [874, 4550], 'domain.': [875, 1341, 4454], 'found': [878, 1446, 4083, 4151], 'cartilage,': [880], 'ligaments,': [881], 'tendons': [883], 'Scholar,10Di': [915], 'Cesare': [916, 945, 1087, 1117, 2887], 'P.E.': [917, 946, 1088, 1118, 2888], 'Hauser': [918, 973, 1093, 1112], 'N.': [919, 974, 1094, 1113, 3332, 4242], 'Lehman': [920], 'Pasumarti': [922], 'S.': [923, 980, 1145, 1653, 1705, 1724, 1851, 1905, 1945, 4305], 'FEBS': [926, 957, 2227], 'Lett.': [927, 958, 2228], '1994;': [928, 1078, 1947, 2898, 3338], '354:': [929], '237-240Crossref': [930], '(220)': [933], 'Cells': [936], 'synovial': [938, 1014], 'express': [940], '(11Di': [944], 'Carlson': [947, 1089], 'C.S.': [948], 'Stollerman': [949], 'Chen': [951], 'F.S.': [952], 'Leslie': [953], 'Perris': [955], 'R.': [956, 1513, 1526, 1793, 1795, 1797, 1925, 1939, 1956, 1964, 2226, 2707], '1997;': [959, 1126, 1482, 1817, 1970, 2229], '412:': [960], '249-252Crossref': [961], '(73)': [964], '12Hummel': [967], 'K.M.': [968], 'Neidhart': [969, 1136], 'Vilim': [971], 'V.': [972, 1509, 1528], 'Aicher': [975], 'W.K.': [976], 'Gay': [977, 979, 1144, 1148], 'R.E.': [978, 1149], 'Häuselmann': [981, 1121, 1146], 'H.J.': [982, 1122, 1147], 'Br.': [983, 1035, 1053, 1123], 'Rheumatol.': [985, 1037, 1055, 1125, 1150], '37:': [987], '721-728Crossref': [988], '(35)': [991], '13Recklies': [994], 'A.D.': [995], 'Baillargeon': [996], 'L.': [997, 1660, 1662, 1726, 2711], 'White': [998], 'C.': [999, 1090, 2224, 4098, 4256], 'Arthritis': [1000], 'Rheum.': [1001, 1076], '41:': [1003], '997-1006Crossref': [1004], '(122)': [1007], 'Although': [1010], 'release': [1012], 'fluid': [1015], 'blood': [1017], 'plasma': [1018], 'serve': [1020], 'as': [1021, 2125, 2289, 2577, 2689, 2915, 2999, 3056, 3259, 3419, 3449, 3525, 3570, 3700, 3992, 3994, 4359], 'diagnostic': [1023], 'marker': [1024], 'early': [1026], 'rheumatoid': [1027], 'arthritis': [1028], '(14Saxne': [1031], '31:': [1039, 1057], '583-591Crossref': [1040], '(309)': [1043], 'Scholar,15Forslind': [1045], 'Eberhardt': [1047], 'Jonsson': [1049], 'Saxne': [1051, 1071], '593-598Crossref': [1058], '(93)': [1061, 1980], 'Scholar)': [1063, 1914, 1982, 2111, 2236, 2905], 'increases': [1065], 'after': [1066, 2659, 3184, 3199, 3400, 4514], 'traumatic': [1067], 'injury': [1068], '(16Lohmander': [1069], 'L.S.': [1070], 'D.K.': [1074], 'Ann.': [1075, 4241], 'Dis.': [1077], '53:': [1079], '8-13Crossref': [1080], '(200)': [1083], '17Di': [1086], 'Stolerman': [1091], 'Tulli': [1095], 'Res.': [1101], '14:': [1103], '946-955Crossref': [1104], '(80)': [1107], '18Neidhart': [1110], 'Di': [1116], 'Michel': [1119], 'B.A.': [1120, 1470], '36:': [1127], '1151-1160Crossref': [1128], '(214)': [1131], '19Kühne': [1134], 'S.A.': [1135, 4106, 4264], 'Everson': [1138], 'M.P.': [1139, 1530], 'Hantzschel': [1140], 'Fine': [1142], 'P.R.': [1143], 'Int.': [1151, 1812], '18:': [1153], '21-25Crossref': [1154], '(39)': [1157], 'Scholar),': [1159, 4548], 'its': [1160, 4570], 'precise': [1161], 'function': [1162], 'established.': [1165], 'II': [1174, 2649, 2668], 'provides': [1178], 'indications': [1179], 'roles': [1182], '(20Rosenberg': [1183, 3002], 'Olsson': [1185, 3004], 'Mörgelin': [1187, 2889, 3006], '273:': [1195, 3014], '20397-20403Abstract': [1196, 3015], '(295)': [1204, 3023], 'All': [1207], 'gene,': [1212], 'are': [1214, 1336, 2013, 4021, 4552], 'known': [1215, 1323], 'or': [1219, 1232, 1237, 2081, 2567, 2624, 3316, 4421], 'MED,': [1220, 1998], 'either': [1223, 2078, 4417], 'single': [1225, 4494], 'acid': [1227, 4069, 4142, 4396], 'substitution,': [1228], 'deletion,': [1231], 'insertion': [1234], 'acids': [1240], '21–32).': [1309], 'Thus': [1310, 1761], 'far,': [1311, 1762], 'no': [1312, 1763, 3760], 'stop': [1314], 'codon': [1315], 'has': [1316], 'been': [1317, 1766, 2657, 2670], 'found.': [1318], 'Most': [1319], '(44': [1320], '48)': [1322], 'residues': [1328, 1400, 2169, 2186, 4143], 'T3': [1331, 1359, 1403, 2011, 2183, 3757, 4019, 4035, 4045], 'repeats,': [1332, 4036, 4046], 'whereas': [1333], '4': [1334, 2192, 2267, 2298, 2326, 3203, 3405], 'located': [1337], '72%': [1342], 'acidic': [1347, 1399], 'residues.': [1348], 'For': [1349, 2392, 3902], 'thrombospondin-1,': [1350], 'it': [1351, 1392, 4013], 'postulated': [1353], 'responsible': [1362, 2014], '13': [1367, 3692], '(33Misenheimer': [1370, 3704], 'T.M.': [1371, 3705], 'Mosher': [1372, 3706], 'D.F.': [1373, 3707], '270:': [1378, 3712], '1729-1733Abstract': [1379, 3713], '(64)': [1387, 3721], 'By': [1390], 'analogy,': [1391], 'speculated': [1394], 'disturb': [1406], 'binding,': [1409], 'folding,': [1410], 'Large': [1415], 'inclusions': [1416, 1444], 'chondrocytes': [1426, 1449], 'contain': [1427], 'COMP,': [1428], 'IX,': [1430, 1583], 'aggrecan': [1432], 'point': [1434, 4062], 'destabilizing': [1437], 'effect': [1438, 3739, 3762], 'mutations.': [1441, 2026], 'tenocytes': [1453], 'ligament': [1455], 'cells': [1456, 2402, 2415, 3357, 4420], '(24Maddox': [1457], 'B.K.': [1458], 'Keene': [1459], 'D.R.': [1460, 1695], 'Sakai': [1461], 'L.Y.': [1462], 'Charbonneau': [1463], 'N.L.': [1464], 'Morris': [1465], 'N.P.': [1466], 'Ridgway': [1467], 'C.C.': [1468], 'Boswell': [1469], 'Sussman': [1471], 'Horton': [1473], 'W.A.': [1474], 'Bächinger': [1475], 'H.P.': [1476], 'Hecht': [1477, 4290], '272:': [1483, 1971], '30993-30997Abstract': [1484], '(91)': [1492], '34Maynard': [1495], 'Cooper': [1497], 'R.R.': [1498], 'Ponseti': [1499], 'I.V.': [1500], 'Lab.': [1501], 'Invest.': [1502], '1972;': [1503], '26:': [1504], '40-44PubMed': [1505], '35Stanescu': [1508], 'Maroteaux': [1510, 1531], 'Stanescu': [1512, 1527], 'Eur.': [1514, 2895], 'Pediatr.': [1516], '1982;': [1517], '138:': [1518], '221-225Crossref': [1519], '(40)': [1522], '36Stanescu': [1525], 'Muriel': [1529], '45:': [1538], '501-507Crossref': [1539], '(65)': [1542], 'shows': [1547], 'genetical': [1549], 'heterogeneity.': [1550], 'This': [1551, 2487, 4079, 4146], 'clinically': [1552], 'defined': [1553], 'entity': [1554], 'but': [1563, 2040, 2840], 'COL9A2': [1569], 'COL9A3': [1572], 'genes': [1573], 'encode': [1575], 'α2': [1577, 1778], 'α3': [1579, 1780], 'chains': [1580, 1748, 1781, 1873], 'respectively': [1584], '(37Muragaki': [1585], 'Mariman': [1587], 'E.C.': [1588], 'van': [1589, 1594], 'Beersum': [1590], 'S.E.': [1591], 'Perala': [1592, 2694], 'Mourik': [1595], 'J.B.': [1596], 'Warman': [1597], 'M.L.': [1598], 'B.R.': [1600, 1811, 1891, 1937], 'Hamel': [1601], 'B.C.': [1602], '12:': [1606], '103-105Crossref': [1607], '(173)': [1610], '38Holden': [1613], 'Canty': [1615], 'E.G.': [1616], 'Zabel': [1619], 'B.': [1620, 1849, 4112, 4270], 'Spranger': [1621], 'Carr': [1623, 4103, 4261], 'Grant': [1625], 'M.E.': [1626], 'Loughlin': [1627], 'Briggs': [1629, 4101, 4229, 4259], 'Hum.': [1633, 1665, 4113, 4271, 4322], '1999;': [1635, 1667, 2715], '65:': [1636], '31-38Abstract': [1637], '(56)': [1645], '39Paassilta': [1648], 'Lohiniva': [1650], 'Annunen': [1652], 'Bonaventure': [1654], 'Le': [1656], 'Merrer': [1657], 'Pai': [1659], 'Ala-Kokko': [1661, 1725, 2710], '64:': [1668], '1036-1044Abstract': [1669], '(106)': [1677], '40Bönnemann': [1680], 'C.G.': [1681], 'Cox': [1682], 'G.F.': [1683], 'Shapiro': [1684], 'F.': [1685], 'Wu': [1686], 'J.J.': [1687], 'Feener': [1688], 'Thompson': [1690], 'T.G.': [1691], 'Anthony': [1692], 'D.C.': [1693], 'Eyre': [1694], 'Darras': [1696], 'B.T.': [1697], 'Kunkel': [1698], 'Proc.': [1700, 1900, 1940], 'Natl.': [1701, 1901, 1941], 'Acad.': [1702, 1902, 1942, 4244], 'Sci.': [1703, 1903, 1943, 4245], 'U.': [1704, 1720, 1904, 1944, 1960], '2000;': [1707, 1731], '97:': [1708], '1212-1217Crossref': [1709], '(92)': [1712], '41Lohiniva': [1715], 'Paassilta': [1717], 'Seppanen': [1719], 'Vierimaa': [1721], 'O.': [1722], 'Kivirikko': [1723], '90:': [1732, 1908], '216-222Crossref': [1733], '(50)': [1736], 'skipping': [1742], 'exon': [1744], 'lead': [1750], 'collagenous': [1752], 'domains': [1753, 4551], 'in-frame': [1755], 'deletions': [1756], '12': [1758], 'acids.': [1760], 'have': [1765], 'reported': [1767], 'α1': [1770], 'complements': [1776], 'heterotrimeric': [1784], 'nonfibrillar': [1785], '(42van': [1788], 'der': [1789], 'Rest': [1790], 'Mayne': [1792, 1794], 'Burgeson': [1796], 'Structure': [1798], 'Function': [1800], 'Collagen': [1802, 1825, 2646, 2654], 'Types.': [1803], 'Academic': [1804], 'Press,': [1805], 'Orlando,': [1806], 'FL1987:': [1807], '195-221Google': [1808], '43Olsen': [1810], 'Biochem.': [1814, 2897, 3599], 'Cell': [1815], '29:': [1818], '555-558Crossref': [1819], '(83)': [1822], 'component': [1830], 'suggested': [1835], 'play': [1837], 'stabilizing': [1839], 'role': [1840], 'fibrils': [1843], '(44Bruckner': [1844], 'Mendler': [1846], 'Steinmann': [1848], 'Huber': [1850], 'Winterhalter': [1852], 'K.H.': [1853], '1988;': [1857], '263:': [1858], '16911-16917Abstract': [1859], 'findings': [1867], 'mice': [1869, 1917], 'expressing': [1870], 'α1(IX)': [1871], 'central': [1876, 4560], 'deletion': [1877, 4129], 'develop': [1878, 1921], '(45Nakata': [1884], 'Ono': [1886], 'Miyazaki': [1888], 'Muragaki': [1892, 1932], 'Adachi': [1894], 'Yamamura': [1896], 'Kimura': [1898], '2870-2874Crossref': [1909], '(166)': [1912], 'lacking': [1918, 2141, 2836, 4478], 'late-onset': [1922], '(46Fässler': [1924], 'Schnegelsberg': [1926], 'P.N.': [1927], 'Dausman': [1928], 'Shinya': [1930], 'McCarthy': [1934], 'M.T.': [1935], 'Jaenisch': [1938], '91:': [1948], '5070-5074Crossref': [1949], '(259)': [1952], '47Hagg': [1955], 'Hedbom': [1957], 'Mollers': [1959], 'Aszodi': [1961], 'Fässler': [1963], 'Bruckner': [1965], '20650-20654Abstract': [1972], 'supported': [1983], 'this': [1984, 2056, 4490, 4506], 'role.': [1985], 'To': [1986], 'understand': [1987], 'consequences': [1989], 'we': [1999, 4052], 'used': [2000, 2817, 2969, 3055, 3114, 3138, 3728, 3888, 4343], 'several': [2004, 3995], 'fragments': [2005, 2211, 2371, 3996, 4442, 4457], 'thereof': [2006, 3997], 'demonstrate': [2008], 'affected': [2023, 2076, 4090], 'mutated': [2031, 2351], 'still': [2034], 'able': [2035, 4427], 'bind': [2037], 'collagens,': [2039], 'fact': [2046], 'interfered': [2059], 'points': [2064], 'common': [2067], 'mechanism': [2068], 'patients': [2075], 'gene.': [2084], 'cDNA': [2086, 2134, 2137, 2167, 2184, 2245, 2260, 2305, 2313, 2356, 4058], 'clone': [2087], 'coding': [2088, 2138, 2252], '(8Oldberg': [2092], 'kind': [2114], 'gift': [2115], 'Å.': [2117], '(Lund': [2119], 'University,': [2120], 'Lund,': [2121], 'Sweden)': [2122, 2967], 'served': [2124, 2288], 'template': [2127, 2291], 'PCR': [2129, 2198, 2264, 2286, 2295], 'amplification': [2130], 'different': [2133, 2819, 2862, 2955, 3062, 3497], 'fragments.': [2135], 'signal': [2143, 2257, 3129, 3272, 3280, 3312, 3430, 3438, 3824, 4333], 'peptide': [2144, 4334], '(rCOMP)': [2145], 'amplified': [2147, 2189], 'according': [2148, 3585], 'standard': [2150], 'protocols': [2151], 'Expand': [2153], 'Polymerase': [2154], '(Roche': [2155], 'Diagnostics)': [2156], 'primer': [2158, 2162, 2174, 2178, 2191, 2195, 2266, 2270, 2279, 2282, 2297, 2300, 2321, 2325, 2328, 2332], '1': [2159, 2419, 2795, 3156, 3860], '(5′-GCCCGCTAGCCCAGGGCCAGATCCCGC-3′)': [2160], 'M1': [2163], '(5′-CAATGACTGCGGCCGCCTAGGCCCTCCGCAG-3′).': [2164], 'EGF-T3': [2166], 'encoding': [2168, 2185, 4138], '227–524': [2170], 'generated': [2172, 2262, 2315], '(5′-GCCCGCTAGCCCACTTCTGCCCCGACG-3′)': [2176], 'M2': [2179, 2280, 2301], '(5′-CAATGACTGCGGCCGCTTAGGCGTTCTCGGGGCAC-3′),': [2180], '268–524': [2187], '(5′-GCCCGCTAGCCCGCGACACAGACCTGG-3′)': [2193], 'M2.': [2196, 2333], 'products': [2199, 2287], 'cloned': [2201], 'pUC18': [2203], 'linearized': [2204, 2237], 'EcoRV.': [2206], 'Excision': [2207], 'NheI/NotI': [2210], 'ligation': [2213], 'pCEP-Pu': [2216], 'expression': [2217, 4001], 'vector': [2218], '(48Kohfeldt': [2219], 'Maurer': [2221], 'Vannahme': [2223], 'Timpl': [2225, 2706], '414:': [2230], '557-561Crossref': [2231], '(203)': [2234], 'withNheI/NotI': [2238], 'joined': [2239], '5′': [2241], '3′': [2248], 'sequence': [2253, 4392], 'BM40': [2256], 'peptide.': [2258], 'T3-D361Y': [2259, 2304, 2342, 2362], 'using': [2265, 2316, 2575, 2880, 2913, 3325], 'mutagenesis': [2269, 2320], '361m': [2271], '(5′-GGTCTGTATACTTCTGGTCATCATTC-3′).': [2272], 'separate': [2274, 2845], 'performed': [2277, 2732, 2998, 3290, 3324, 3448], '361c': [2283], '(5′-GACCAGAAGTATACAGACCGGGATG-3′).': [2284], 'final': [2294], 'amplify': [2303], 'ligated': [2308], 'pCEP-Pu.': [2311], 'T3-D469Δ': [2312, 2348], 'combination': [2318], '469m': [2322], '(5′-GTCGTCGTCATCGCATGCATCACCCTT-3′)': [2323], '469c': [2329], '(5′-GGTGATGCATGCGATGACGACGAC-3′)': [2330], 'Additional': [2334], 'silent': [2335], 'created': [2337], 'novel': [2339], 'Bst1107I': [2340], 'newSphI': [2345], 'site': [2346], 'identify': [2350], 'clones.': [2352], 'D361Y': [2353], 'clones': [2357, 2380], 'constructed': [2359], 'digesting': [2361], 'T3-D469Δ,': [2364], 'respectively,': [2365], 'ClaI/BstBI': [2367], 'ligating': [2369], 'these': [2370], 'theClaI/BstBI-digested': [2373], 'rCOMP': [2374, 3991, 4352, 4568], 'cDNA.': [2375], 'Correct': [2376], 'sequences': [2377], 'all': [2379, 2617, 3369], 'confirmed': [2382, 2448, 2640, 2936, 4503, 4517], 'sequencing': [2384, 2632, 4388, 4502], '(ABI': [2385], 'Prism': [2386], '377': [2387], 'DNA': [2388], 'Sequencer;': [2389], 'Applied': [2390], 'Biosystems).': [2391], 'stable': [2393], 'episomal': [2394], 'expression,': [2395], '5': [2396, 2593, 3181, 3305, 3389], '×': [2397, 3263, 3422, 3661, 3678], '105': [2398], 'embryonic': [2400], 'kidney': [2401], '(293-EBNA;': [2403], 'Invitrogen)': [2404], 'electroporated': [2406], 'μg': [2409], 'purified': [2411, 2588], 'plasmid.': [2412], 'transfected': [2414, 2454], 'selected': [2417], 'μg/ml': [2420, 2739], 'puromycin': [2421], 'grown': [2423], 'confluence': [2425], "Dulbecco's": [2427], 'modified': [2428], "Eagle's": [2429], "medium:Ham's": [2430], 'F-12': [2431], '10%': [2433], 'fetal': [2434], 'calf': [2435], 'serum': [2436, 2781], '(Life': [2437], 'Technologies,': [2438], 'Inc.).': [2439], 'Secretion': [2440], 'proteins': [2443, 2618, 3175, 3371, 4338, 4347], 'SDS-PAGE': [2450, 2622], 'samples': [2452], 'nontransfected': [2456], 'Serum-free': [2458], 'harvested,': [2462], 'supplemented': [2463, 2869], '0.5': [2465, 2505, 2544, 2811, 3929], 'phenylmethylsulfonyl': [2467, 2546], 'fluoride': [2468], '25': [2470, 3168, 3359], 'Tris-HCl': [2472], 'give': [2474, 3928], '8.6,': [2478, 2512], 'filtered': [2480], 'through': [2481], 'Sephadex': [2482], 'G-25': [2483], '(Amersham': [2484, 2497, 2536, 2572, 2602, 3493], 'Pharmacia': [2485, 2498, 2537, 2573, 2603, 3494], 'Biotech).': [2486], 'applied': [2490], 'Q-Sepharose': [2493], 'FastFlow': [2494], 'ion-exchange': [2495, 2561, 2582], 'column': [2496, 2571, 2601], 'Biotech)': [2499, 2538, 2574, 3495], 'equilibrated': [2500, 2539], '50': [2502, 2508, 2541, 2549, 2761], 'NaCl,': [2504, 2543, 3086], 'mmphenylmethylsulfonyl': [2506], 'fluoride,': [2507, 2547], 'Tris-HCl,': [2510, 2551, 2595], 'eluted': [2514], 'gradient': [2517], '50–1000': [2519], 'NaCl': [2521, 2768], 'same': [2524], 'buffer.': [2525], 'COMP-containing': [2526], 'fractions': [2527], 'subjected': [2529], 'filtration': [2532], 'Sepharose': [2534], 'CL-6B': [2535], '8.6.': [2553], 'Final': [2554], 'purification': [2555], 'concentration': [2557, 2833, 3567, 3652, 3683], 'achieved': [2559], 'chromatography': [2562], 'Resource': [2565], 'Q': [2566, 2570], 'Source': [2569], 'buffers': [2576, 2867, 3246], 'described': [2578, 2690, 3000, 3450, 3787], 'first': [2581, 3808, 3830, 4407], 'chromatography.': [2583], 'buffer': [2585], 'sample': [2589, 3932], 'changed': [2591], 'PD10': [2600], 'Biotech),': [2604], 'aliquots': [2606, 3296, 3503], 'stored': [2608], '−80': [2610], '°C.': [2611, 2753, 3169, 3360], 'purity': [2613], 'size': [2615], 'assessed': [2620], 'without': [2625], 'prior': [2626], 'reduction': [2627], 'disulfide': [2629, 4006], 'bonds.': [2630], 'Amino-terminal': [2631, 4501], 'ABI473A/476A': [2635], 'Sequencer': [2636], '(PerkinElmer': [2637], 'Life': [2638, 3349], 'Sciences)': [2639], 'identity': [2642], 'proteins.': [2645], 'purchased': [2651], 'Sigma.': [2653], 'had': [2656, 2669, 3735, 3759], 'pepsin': [2660], 'digestion': [2661], 'bovine': [2663, 2673, 2780], 'dermal': [2664], 'skin,': [2665], 'nasal': [2674], 'septum.': [2675], 'Each': [2676], 'dissolved': [2679, 3176, 3478], '0.5m': [2681], 'acetic': [2682], 'acid.': [2683], 'Recombinant': [2684], 'produced': [2688, 4048], 'previously': [2691, 3001], '(49Pihlajamaa': [2692], 'Vuoristo': [2696], 'M.M.': [2697], 'Nokelainen': [2698], 'Bodo': [2700], 'Vuorio': [2704], '22464-22468Abstract': [2717], '(37)': [2725], 'Ligand': [2728], 'studies': [2730], 'solid-phase': [2734], 'assays': [2735], '(2': [2738], '0.18': [2741], 'macetic': [2742], 'acid)': [2743], 'coated': [2744, 2949], '96-well': [2746], 'plates': [2747], '(Maxisorb;': [2748], 'Nunc)': [2749], 'overnight': [2750], '20': [2752, 2759, 3079, 3089, 3748], 'After': [2754, 2788, 3499], 'washing': [2755, 2789, 2866], '0.05%': [2757], 'Tween': [2758, 3088], '(TBS),': [2769], 'wells': [2771, 2791, 2835], 'blocked': [2773], '1.5': [2775, 3190], 'h': [2776, 2796], 'mg/ml': [2779], 'albumin': [2782], 'TBS': [2784, 2809, 2858, 3178, 3386, 3480, 3487], 'room': [2786, 2798], 'temperature.': [2787], 'incubated': [2793], 'temperature': [2799], 'ligands': [2801, 2815, 2853], 'tCOMP,': [2802, 2873, 2983, 3034], 'rCOMP,': [2803, 2874, 2984, 3039], 'diluted': [2807, 2856, 3934], 'containing': [2810, 2859, 3090, 3488], 'ZnCl2.': [2813, 2871], 'concentrations': [2820, 3063, 3582, 3642, 3727], 'determination': [2823], 'Nonspecific': [2826], 'controlled': [2829], 'each': [2831, 3507, 3850], 'ligand': [2832], 'coat': [2839], 'otherwise': [2841], 'treated': [2842], 'identically.': [2843], 'experiments,': [2846], 'zinc-dependent': [2848], 'measured': [2851, 3172, 3345], '(5': [2854], 'nm)': [2855, 3068], 'concentrations.': [2863], 'Also': [2864], 'Bound': [2872], 'D469D': [2877], 'detected': [2879, 2953], 'polyclonal': [2882, 2959], 'antiserum': [2883], 'against': [2884, 2930, 3483, 3917, 4574], '(50Di': [2886], 'Mann': [2891], '223:': [2899], '927-937Crossref': [2900], '(125)': [2903], 'peroxidase-coupled': [2908], 'swine': [2909], 'anti-rabbit': [2910], 'IgG': [2911], '(DAKO)': [2912], 'tetramethylbenzidine': [2914], 'chromogenic': [2916], 'substrate,': [2917], 'absorbance': [2919], 'recorded': [2921, 3149, 3384], '450': [2923], 'nm.': [2924, 3381], 'Identical': [2925], 'titers': [2926], 'antibodies': [2929], 'enzyme-linked': [2938], 'immunosorbent': [2939], 'assay': [2940], 'titrations': [2941, 3288, 3446], 'onto': [2950, 3941, 3972], 'plastic': [2951], 'dilutions': [2956], 'antiserum.': [2960], 'BIAcore': [2962], '2000': [2963], 'system': [2964, 4002], '(BIAcore,': [2965], 'Uppsala,': [2966], 'characterize': [2971], 'interaction': [2973], 'between': [2974, 3377, 3537, 3573, 3745, 3750, 3846, 4401], 'collagens.': [2980], 'Immobilization': [2981], 'carboxymethylated': [2990], 'CM5': [2994], 'sensor': [2995], 'chip': [2996], 'immobilization': [3027], 'resulted': [3028, 3126], '9,100': [3030], 'resonance': [3031, 3036, 3041, 3047, 3135], '4,600': [3035], '3,300–3,600': [3040], '3,400–5,200': [3046], 'D469Δ.': [3050], 'blank': [3052], 'surface': [3053], 'control.': [3057], 'Binding': [3058], 'determined': [3060, 3462, 3584, 3701], '(2–136': [3067], '(11–88': [3072], 'nm).': [3073], 'added': [3077, 3926], 'HEPES,': [3081], '0.005%': [3087], '0.05': [3091], 'chloride': [3094], 'before': [3095], 'injection': [3096], 'avoid': [3098], 'fiber': [3099], 'formation.': [3100], 'flow': [3102], 'rate': [3103], '80': [3105], 'μl/min': [3106], 'used.': [3108], 'BIAevaluation': [3109], 'software': [3110], 'version': [3111], '3.0': [3112], 'calculateKd': [3116], 'binding.': [3119], 'Only': [3120], 'curves': [3121], 'association': [3125], 'response': [3130], 'more': [3132], 'than': [3133, 3180, 3388, 3732], 'calculations.': [3140], 'CD': [3141, 3165, 3253, 3279, 3311], 'spectra': [3142, 3234, 3244], 'far': [3145], 'UV': [3146], 'thermostated': [3152], 'quartz': [3153], 'optical': [3158], 'path': [3159], 'length': [3160], 'JASCO': [3163], '715': [3164], 'spectropolarimeter': [3166], 'Spectra': [3170, 3382], '(less': [3179, 3387], 'μmCa2+)': [3182], '0.25': [3188], 'mmCaCl2.': [3191], 'Reversal': [3192], 'conformational': [3195], 'change': [3196, 3251, 3410, 4073], 'examined': [3198, 3982], 'EDTA': [3205], 'Ca2+-containing': [3208], 'samples.': [3209], 'Mean': [3210], 'molar': [3211], 'ellipticities': [3212], '[Θ]': [3213], '(expressed': [3214], 'degrees': [3216, 3803], 'cm2': [3217], 'dmol−1)': [3218], 'calculated': [3220, 3258, 3418, 3524, 3569, 3614, 3644], 'basis': [3223], 'mean': [3226], 'residue': [3227], 'molecular': [3228, 4371], 'mass': [3229], '110': [3231, 4497], 'Da.': [3232], 'Five': [3233], 'accumulated': [3236], 'improve': [3238], 'signal/noise': [3240], 'ratio,': [3241], 'subtracted.': [3248], 'percentage': [3250, 3409, 3820], '215': [3255, 3314], 'nm': [3256, 3315, 3367, 3416], 'Δ[Θ]215': [3260], '=': [3261, 3527, 3623, 3656, 3691, 3790], '100': [3262, 3421, 4382, 4439], '([Θ]Ca': [3264], '−': [3265, 3424, 3658, 3795], '[Θ]EDTA)/': [3266], '[Θ]Ca,': [3267], '[Θ]Ca': [3269], 'representing': [3270, 3277, 3428, 3435, 3532, 3542, 3548, 3555, 3671, 3680, 3801], 'Ca2+saturation,': [3274, 3432], '[Θ]EDTA': [3276], 'presence': [3283, 3394, 3441], 'excess': [3285, 3443], 'EDTA.': [3286, 3407, 3444], 'Calcium': [3287, 3445], 'CaCl2': [3298, 3398], 'stock': [3299], 'solution': [3300], 'incubation': [3303], 'min': [3306], 'recording': [3308, 3317], 'spectra.': [3319], 'Secondary': [3320], 'structure': [3321, 4521], 'analysis': [3322], 'variable': [3327], 'selection': [3328], 'method': [3329, 3587], 'SelCon': [3330], '(51Sreerama': [3331], 'Woody': [3333], 'R.W.': [3334], 'Mol.': [3336], '242:': [3339], '497-507PubMed': [3340], 'Fluorescence': [3343], 'PerkinElmer': [3348], 'Sciences': [3350], 'LS50B': [3351], 'spectrophotometer': [3352], '10-mm': [3354], 'pathlength': [3355], 'rectangular': [3356], 'Intrinsic': [3361], 'fluorescence': [3362, 3412, 3437], 'excited': [3364], '280': [3366], '(1': [3372, 3794], 'μm).': [3373], 'Emission': [3374], 'maxima': [3375], '346': [3378], '353': [3380], 'μm': [3390], 'Ca2+)': [3391], '2': [3396], 'subsequent': [3402], 'intensity': [3413], '350': [3415], 'ΔF350=': [3420], '(FCa': [3423], 'FEDTA)/FCa,': [3425], 'FCa': [3427], 'FEDTA': [3434], 'above.': [3451], 'per': [3458], 'molecule': [3460], 'equilibrium': [3464, 3872], 'dialysis': [3465, 3508, 3539], 'microdialysis': [3467], 'chambers': [3468], '(Membrapure,': [3469], 'Bodenheim,': [3470], 'Germany).': [3471], 'μl': [3473, 3485], '(10': [3476], 'μm)': [3477, 3914], 'dialyzed': [3482, 3916, 4573], '0.2': [3489], 'μCi': [3490], '45Ca2+': [3492], '40CaCl2concentrations.': [3498], '16–20': [3500], 'h,': [3501], '10-μl': [3502], 'removed': [3505, 4464], 'chamber': [3509], 'counted': [3511], 'scintillation': [3514], 'counter.': [3515], 'B': [3522, 3526], 'Δcpm/cpmtotal': [3528], '×nCa/nprotein,': [3529], 'Δcpm': [3531], 'difference': [3534, 3572], 'radioactivity': [3536], 'chambers,': [3540], 'cpmtotal': [3541], 'sum': [3544], 'activities,nCa': [3547], 'ions,': [3553], 'andnprotein': [3554], 'molecules': [3560], 'system.': [3563], 'free': [3565, 3640, 3865], 'total': [3575, 3650, 3673, 3682], 'concentration.': [3580], 'Protein': [3581], 'Gill': [3589], 'von': [3591, 3595], 'Hippel': [3592, 3596], '(64Gill': [3593], 'S.C.': [3594], 'P.H.': [3597], 'Anal.': [3598], '1989;': [3600], '182:': [3601], '319-326Crossref': [3602], '(5073)': [3605], 'degree': [3609, 3771], 'saturation': [3611, 3773, 3805, 3827], 'Y': [3612, 3646, 3659, 3774, 3789, 3855], 'signals': [3617, 3632], 'S,': [3618], 'corrected': [3619], 'dilutions,': [3621], 'asY': [3622], '(S': [3624], '−S0)/(SCa': [3625], '−S0),': [3626], 'where': [3627], 'SCa': [3628], 'andS0': [3629], 'represent': [3630, 3870, 3878], 'Ca2+saturation': [3634], '0': [3636], 'Ca2+,': [3637], 'Ca2+': [3641, 3697, 3866], 'corresponding': [3649], 'Ca2+tot': [3653, 3657], 'to:': [3654], 'Ca2+free': [3655], '×n': [3660], 'Ptot,': [3662], 'nrepresenting': [3664], 'sites/molecule,Ptot': [3670], 'concentration,': [3675], 'n': [3677, 3734], 'Ptot': [3679], 'sites': [3686, 3784, 3834, 3848, 3854], 'present.': [3687], 'initially': [3689], 'usedn': [3690], 'sites/molecule,': [3699], 'thrombospondin-1': [3703], 'Because': [3724, 4012], 'much': [3730], 'lower': [3731, 4370], 'Ca2+tot,': [3733], 'negligible': [3738], 'Ca2+free.': [3741], 'Thus,': [3742], 'variation': [3743], 'ofn': [3744], 'significant': [3761], 'calculatedKd': [3765], 'values': [3766], 'Hill': [3768, 3841, 3880], 'coefficients.': [3769, 3881], 'model': [3777, 3892], 'including': [3778, 4458], 'independent': [3780], 'classes': [3781], 'a×': [3791], 'Y1': [3792, 3799], '+': [3793], 'a)': [3796], '×Y2,': [3797], 'andY2': [3800], 'second': [3810, 4125], 'class': [3811, 3831, 3851], 'sites,': [3814], 'parameter': [3817], 'arepresenting': [3818], 'contribution': [3821], 'induced': [3825], 'whole': [3837], 'signal.': [3838], 'Using': [3839], 'equation': [3842], 'describe': [3844], 'within': [3849, 4398, 4418], 'given': [3857], 'Y=a×([Ca]nH1/Equation': [3859], '(Kd1nH1+[Ca]nH1))+(1−a)×([Ca]nH2/(Kd2nH12+[Ca]nH12))where': [3861], '[Ca]': [3862], 'represents': [3863, 4508], 'concentration,Kd1': [3867], 'Kd2': [3869], 'dissociation': [3873], 'constants,': [3874], 'nH1': [3876], 'andnH2': [3877], 'program': [3883], 'Grafit': [3884], '(Erithacus': [3885], 'software)': [3886], 'fit': [3890, 3900], 'experimental': [3895], 'data': [3896], 'nonlinear': [3898], 'least-square': [3899], 'procedures.': [3901], 'visualization': [3903], 'electron': [3905, 3987], 'microscopy,': [3906], '(0.1': [3913], '0.15': [3918], 'm': [3919], 'ammonium': [3920], 'formate,': [3921], '7.4.': [3923], 'ZnCl2': [3924], 'mmZn2+.': [3930], '1:1': [3935], '80%': [3937], 'glycerol': [3938], 'sprayed': [3940], 'freshly': [3942], 'cleaved': [3943, 4435], 'mica,': [3944], 'dried': [3945], 'vacuum,': [3947], 'rotary': [3949, 4515], 'shadowed': [3950], 'platinum/carbon': [3952], '(52Engel': [3953], 'Furthmayr': [3955], 'Methods': [3957], 'Enzymol.': [3958], '1987;': [3959], '145:': [3960], '3-78Crossref': [3961], '(137)': [3964], 'replicas': [3968], 'floated': [3970], 'off': [3971], 'destilled': [3973], 'water,': [3974], 'picked': [3975], 'up': [3976], '400-mesh': [3978], 'copper': [3979], 'grids,': [3980], 'Zeiss': [3985], '902': [3986], 'microscope.': [3988], 'well': [3993], 'eukaryotic': [4000], 'ensure': [4004], 'proper': [4005], 'bond': [4007], 'formation': [4008], 'posttranslational': [4010], 'modifications.': [4011], 'unclear': [4015], 'whether': [4016], 'independently': [4022], 'folded,': [4023], 'construct': [4025, 4039], 'EGF-T3,': [4026], 'fourth': [4029], 'EGF': [4030], 'plus': [4032], 'T3,': [4040], '(Fig.': [4049, 4350, 4499, 4563], '1).': [4050], 'Furthermore,': [4051], 'introduced': [4053], 'mutation': [4063, 4080, 4126, 4152], 'G1106T': [4064], 'results': [4065], 'level': [4070], '(D361Y).': [4078], 'originally': [4082], 'seven': [4089], 'members': [4091], 'suffering': [4092], '(28Loughlin': [4095], 'Irven': [4097, 4255], 'Mustafa': [4099, 4257], 'Z.': [4100, 4258], 'Lynch': [4105, 4263], 'Sykes': [4111, 4269], 'Mutat.': [4114, 4272], 'Suppl.': [4116, 4274], '1:': [4117, 4275], 'S10-S17Crossref': [4118, 4276], '(33)': [4121, 4279], 'five': [4134, 4139, 4446, 4549], 'triplets': [4135], '(nucleotides': [4136], '1430–1444)': [4137], 'consecutive': [4140], 'aspartic': [4141], '469–473': [4144], '(D469Δ).': [4145], 'most': [4149], 'commonly': [4150], 'causes': [4156], '21Cohn': [4227], 'Wilcox': [4235], '785:': [4247], '188-194Crossref': [4248], '(49)': [4251], 'Scholar,28Loughlin': [4253], '29Deere': [4282], 'Sanford': [4284], 'Ferguson': [4286], 'H.L.': [4287], 'Daniels': [4288], '80:': [4297], '510-513Crossref': [4298], '(60)': [4301], '30Ikegawa': [4304], 'Ohashi': [4306], 'Nishimura': [4308], 'G.': [4309], 'Kim': [4310], 'K.C.': [4311], 'Sannohe': [4312], 'Kimizuka': [4314], 'Fukushima': [4316], 'Nagai': [4318], 'Nakamura': [4320], '103:': [4325], '633-638Crossref': [4326], '(63)': [4329], 'targeted': [4335], 'media': [4342], 'purify': [4345], 'homogeneity': [4349], '2).': [4351, 4500], 'present': [4354, 4416], 'pentamer': [4361], 'about': [4363], '550': [4364], 'kDa,': [4365], 'although': [4366], 'bands': [4367], 'migrating': [4368], 'masses': [4372], 'observed': [4375], 'under': [4376], 'nonreducing': [4377], 'conditions.': [4378], 'band': [4380, 4461, 4495, 4507], 'kDa': [4383, 4440, 4498], 'isolated,': [4385], 'amino-terminal': [4387], 'started': [4393], '78': [4397], 'linker': [4400], 'EGF-like': [4408], '(results': [4410], 'shown).': [4412], 'Apparently,': [4413], 'protease': [4415], 'cleave': [4429], 'subunits,': [4432], 'yielding': [4433], 'parts': [4437], 'intact': [4447], 'subunits': [4448], 'connected': [4449, 4553], 'via': [4450], 'smaller': [4456], '100-kDa': [4460], 'could': [4462], 'chromatographically,': [4465], 'preparation': [4468, 4491], 'portion': [4474], 'particles': [4477], 'part': [4481], 'obtained.': [4486], 'Under': [4487], 'reducing': [4488], 'conditions,': [4489], 'Electron': [4512], 'microscopy': [4513, 4566], 'shadowing': [4516], 'mainly': [4519], 'rCOMP.': [4523], 'As': [4524], 'seen': [4525], 'earlier': [4526], 'tCOMP': [4528], 'thin': [4555], 'flexible': [4556], 'strands': [4557], 'assembly': [4561], '3).Figure': [4564], '3Electron': [4565], 'mutants.': [4571], 'Proteins': [4572]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2168681970', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': 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