Identifying Structural Features of Fibrillar Islet Amyloid Polypeptide Using Site-directed Spin Labeling

Name: Work Video:
Duration: 3 min 30 s
Sajith Jayasinghe; Ralf Langen
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4057], '90%': [20, 231, 439], 'patients': [22, 233, 441], 'with': [23, 33, 90, 106, 160, 195, 234, 244, 301, 317, 371, 406, 442, 955, 1234, 1376, 1568, 1830, 1915, 1932, 2097, 2112, 2168, 2201, 2244, 2331, 2385, 2396, 2416, 2490, 2507, 2520, 2616, 2719, 2738, 2772, 2812, 2986, 3089, 3189, 3192, 3220, 3232, 3308, 3389, 3410, 3421, 3434, 3467, 3688, 3786, 3860, 3899, 4159, 4194, 4556, 4635, 4643, 4782, 5494, 5611, 5687], 'type': [24, 235, 443, 635], 'II': [25, 236, 444, 636], 'diabetes.': [26, 237], 'Although': [27, 238, 739, 1055, 2993, 4109, 5152, 5509], 'IAPP': [28, 67, 165, 239, 278, 376, 631, 770, 868, 1016, 1556, 1586, 1594, 1682, 1702, 1740, 1776, 1885, 2106, 2119, 2122, 2288, 2301, 2412, 2445, 2469, 2608, 2681, 2706, 2816, 2868, 3017, 3115, 3129, 3138, 3153, 3180, 3248, 3285, 3306, 3326, 3358, 3373, 3431, 3439, 3528, 3582, 3598, 3686, 3770, 3780, 3869, 3950, 4075, 4087, 4144, 4189, 4198, 4576, 4990, 5181, 5235, 5250, 5272, 5340, 5378, 5484, 5580, 5641, 5677, 5691, 5701, 5717, 5731, 5767], 'deposits': [30, 241, 424, 448, 494, 633, 742, 759, 771, 1022, 1067], 'associated': [32, 243, 2737], 'areas': [34, 245, 450], 'pancreatic': [36, 247, 740], 'β-cell': [38, 249, 452], 'dysfunction': [39, 250, 453], 'and': [40, 42, 110, 124, 141, 201, 251, 253, 321, 335, 352, 412, 454, 620, 862, 937, 1038, 1077, 1085, 1115, 1146, 1227, 1338, 1425, 1642, 1683, 1690, 1693, 1800, 1815, 1853, 1908, 1936, 1984, 2042, 2094, 2125, 2221, 2256, 2278, 2377, 2398, 2404, 2427, 2429, 2435, 2505, 2691, 2704, 2715, 2759, 2789, 2808, 2866, 2944, 3079, 3085, 3092, 3124, 3143, 3254, 3343, 3356, 3402, 3414, 3440, 3450, 3460, 3502, 3507, 3548, 3553, 3574, 3612, 3650, 3702, 3758, 3782, 3831, 3894, 3976, 3986, 4020, 4028, 4082, 4103, 4150, 4454, 4530, 4538, 4630, 4752, 4865, 4900, 4989, 5228, 5251, 5273, 5467, 5488, 5498, 5603, 5607, 5635, 5754, 5777, 5787], 'depletion': [41, 252], 'thought': [44, 255], 'to': [45, 61, 71, 85, 153, 197, 256, 272, 282, 296, 364, 408, 960, 1069, 1080, 1125, 1335, 1378, 1429, 1578, 1601, 1878, 2067, 2211, 2270, 2276, 2612, 2620, 2804, 2869, 2881, 2884, 2955, 3001, 3022, 3057, 3116, 3166, 3186, 3243, 3251, 3379, 3407, 3521, 3579, 3827, 3914, 3924, 4045, 4069, 4098, 4281, 4313, 4340, 4469, 4499, 4532, 4580, 4768, 5167, 5234, 5256, 5316, 5384, 5530, 5671, 5711, 5725, 5756, 5761], 'play': [46, 257, 5174], 'role': [48, 259, 5039, 5176], 'disease,': [50, 261, 1035, 1037], 'their': [51, 262, 1345, 3141, 5260], 'structure': [52, 263, 886, 1058, 1130, 2807, 3235, 3804, 4095, 4105, 4364, 4422, 4765, 5382], 'is': [53, 189, 264, 400, 495, 1009, 1392, 1599, 2576, 2583, 2593, 2999, 3010, 3272, 3351, 3542, 3783, 4309, 4322, 4467, 4757, 5081, 5130, 5191, 5462, 5581], 'unknown.': [54, 265], 'We': [55, 266, 1550, 3071, 3176, 4137, 4275, 4418, 5772], 'used': [56, 267, 504, 540, 1333, 1371, 1428, 2689, 3055, 4496], 'electron': [57, 86, 268, 297, 511, 524, 547, 560, 938, 1228], 'paramagnetic': [58, 87, 269, 298, 525, 561, 1229], 'resonance': [59, 88, 270, 299, 1150, 1157, 1230], 'spectroscopy': [60, 271, 1232, 1373], 'analyze': [62, 273], 'eight': [63, 81, 274, 292, 3148, 3592, 3637, 3909, 4114, 4295, 4551], 'spin-labeled': [64, 275, 1854], 'derivatives': [65, 82, 276, 293], 'an': [69, 280, 1439, 1759, 1960, 1994, 2169, 2194, 2332, 2729, 2802, 3366, 3577, 3669, 4409, 4491, 5232], 'effort': [70, 281], 'determine': [72, 283, 2675, 4470, 4500], 'structural': [73, 284, 755, 1337, 1380, 2735, 3168, 4072, 4133, 5674, 5714, 5728], 'features': [74, 285, 756, 1340, 1381, 3212, 3283, 5675, 5729], 'peptide.': [77, 113, 288, 324, 3175, 4065, 5097], 'In': [78, 114, 289, 325, 1153, 1366, 1385, 2972, 3241, 3488, 3625, 3711, 3840, 4345, 4621, 4770, 5076, 5184, 5200, 5663], 'solution,': [79, 290], 'all': [80, 291, 3591, 3636, 3883, 3908, 4113, 4294, 4524, 4550, 5194, 5616], 'gave': [83, 294, 3184, 3249], 'rise': [84, 295, 3185, 3250, 3406], 'spectra': [89, 103, 116, 300, 314, 327, 1412, 2173, 2306, 2347, 2409, 2442, 2711, 2725, 2744, 3188, 3320, 3409, 3422, 3566, 3602, 3627, 3684, 3865, 3885, 4361, 4632], 'sharp': [91, 302, 3190], 'lines': [92, 303, 622, 3191, 3415, 3464, 3893, 3897, 3982], 'indicative': [93, 304, 2796], 'rapid': [95, 306], 'motion': [96, 307], 'on': [97, 308, 1758, 1778, 1993, 2158, 2484, 2815, 3370, 3382, 3801, 3851, 3917, 4302, 4317, 4403, 4575], 'sub-nanosecond': [99, 310, 3227], 'time': [100, 311, 2334, 2937, 3224, 3228, 4406], 'scale.': [101, 312], 'These': [102, 313, 1674, 2724, 2793, 3210, 3281, 3535], 'consistent': [105, 159, 316, 370, 5686], 'rapidly': [108, 319], 'tumbling': [109, 320], 'highly': [111, 322, 1565, 2987, 3216, 4093, 4758, 5586], 'dynamic': [112, 323, 1339, 4094], 'contrast,': [115, 326, 1154, 3626, 5201], 'for': [117, 328, 1604, 1803, 1836, 1858, 1967, 1988, 2001, 2072, 2356, 2365, 2497, 2517, 2530, 2595, 2666, 3076, 3204, 3284, 3312, 3322, 3348, 3524, 3567, 3685, 3960, 3983, 4207, 4428, 4463, 4534, 4586, 4742, 4780, 4869, 5132, 5160, 5339, 5506, 5533, 5600, 5780, 5791], 'fibrillar': [119, 330, 777, 889, 1019, 1136, 1346, 1559, 1597, 2468, 2588, 2751, 2871, 3144, 3247, 3270, 3560, 3707, 3716, 3769, 3815, 3838, 3868, 4078, 4121, 5444, 5626, 5680, 5770], 'form': [120, 331, 890, 1137, 1347, 1560, 1598, 2543, 2613, 2870, 3117, 3508, 3697], 'exhibit': [121, 332, 446], 'reduced': [122, 333, 3388, 3411, 3457, 4118, 4420], 'mobility': [123, 175, 334, 386, 3810, 3996, 4111, 4128, 4175, 4285], 'presence': [126, 337, 774, 880, 1526, 3314, 3479, 3619, 4164, 4289, 4450, 4482, 4545], 'strong': [128, 339], 'intermolecular': [129, 340, 3647], 'spin-spin': [130, 341, 1528, 3295, 3316, 3400, 3482, 3623, 3648, 3823, 3844, 4167, 4628, 5455], 'interactions.': [131, 342, 3624, 5456], 'The': [132, 343, 489, 1591, 1711, 1725, 2056, 2259, 2862, 3346, 4016, 4572, 4639, 5247, 5457], 'latter': [133, 344], 'implies': [134, 345, 2657], 'that': [135, 142, 346, 353, 946, 1552, 1602, 1677, 2541, 2621, 2658, 3012, 3098, 3178, 3416, 3499, 3522, 3538, 3549, 3753, 3822, 4049, 4086, 4129, 4139, 4177, 4201, 4278, 4298, 4332, 4514, 4753, 4760, 5125, 5170, 5236, 5331, 5372, 5385, 5452, 5472, 5575, 5593, 5604, 5615, 5651], 'peptide': [137, 207, 348, 418, 948, 1607, 1761, 1872, 1938, 1970, 1991, 2030, 2058, 2231, 2262, 2626, 3583, 3968, 4308, 4590, 4901, 5207, 5621], 'subunits': [138, 349], 'ordered': [140, 351, 1566, 3933, 5450, 5587, 5697], 'same': [144, 355, 1570, 2213, 4315], 'residues': [145, 356, 1571, 1744, 2540, 2606, 3106, 3953, 4018, 4035, 4179, 4202, 5088, 5197, 5230, 5317, 5633], 'from': [146, 357, 871, 1521, 1572, 1697, 1705, 1719, 1732, 1784, 2088, 2295, 2298, 2747, 2801, 3170, 3291, 3324, 3338, 3423, 3428, 3453, 3513, 3526, 3570, 3590, 3604, 3655, 3746, 3778, 3866, 4043, 4091, 4337, 4353, 4399, 4460, 4517, 4583, 5536, 5695], 'neighboring': [147, 358, 3384, 3656, 3779, 3918, 4318, 4338, 4461], 'peptides': [148, 166, 359, 377, 1587, 1790, 1812, 1827, 1855, 1900, 2601, 3081, 3504, 3555, 3781, 4339, 5244, 5275, 5609], 'close': [151, 362, 1576, 3000, 3377, 3651, 3663, 3773, 3922, 4311, 5529], 'proximity': [152, 363, 1577, 3378, 3652, 3664, 3774, 3923, 4312], 'one': [154, 365, 1579, 3925], 'another.': [155, 366], 'Our': [156, 367, 3817, 4066, 5682], 'data': [157, 368, 2814, 3532, 3536, 4574, 4751, 5667, 5684], 'parallel': [162, 373, 1583, 4104, 4565, 4764, 4773, 5134, 5240, 5698], 'arrangement': [163, 374, 1584, 4566, 4738, 4774, 5135, 5146, 5241, 5699], 'within': [167, 378, 1588, 3545, 4060, 4135, 4169, 4182, 4342, 4415, 4430, 4526, 4569, 5136, 5182, 5218, 5245, 5583], 'fibril.': [170, 381, 1590, 4108, 4190, 4417, 4571], 'Analysis': [171, 382], 'spin': [173, 384, 529, 565, 1236, 1390, 1531, 1712, 1824, 1912, 3331, 3496, 3818, 4291, 4401, 4452, 4484, 4518, 4547], 'label': [174, 385, 1391, 1424, 3219, 3368, 3381, 3541, 4000, 4301], 'indicates': [176, 387, 878, 3477, 3498, 3771, 4563], 'high': [178, 389, 1796, 1849, 3858, 4522], 'degree': [179, 390], 'order': [181, 392, 5465, 5505], 'throughout': [182, 393, 3163], 'peptide,': [184, 395, 3862], 'although': [185, 396, 4435], 'N-terminal': [187, 398, 2604, 3014, 4017, 4052, 5093, 5188, 5458, 5485, 5595, 5653], 'region': [188, 399, 3948, 4142, 4529, 5313, 5451, 5459, 5654], 'slightly': [190, 401, 3978], 'less': [191, 402, 3956, 3979, 4055], 'ordered.': [192, 403], 'Possible': [193, 404], 'similarities': [194, 405, 1675, 3096, 5248, 5265], 'respect': [196, 407], 'domain': [199, 410], 'organization': [200, 411, 1592, 4073, 5046, 5179, 5258], 'parallelism': [202, 413], "Alzheimer's": [204, 415, 1034, 1605, 4588], 'β': [206, 417], 'fibrils': [208, 419, 869, 943, 1608, 1685, 2085, 2126, 2296, 2413, 2615, 2671, 2886, 2985, 3286, 3323, 3335, 3509, 3511, 3525, 3568, 4352, 5049, 5333, 5692], 'discussed.': [210, 421], 'have': [425, 625, 944, 1023, 1331, 2609, 3517, 4276, 5034, 5155, 5511, 5668, 5708], 'been': [426, 1024, 1123, 1332, 2610, 5035, 5051, 5158, 5709], 'identified': [427, 749, 1025], 'as': [428, 873, 875, 1033, 1074, 1143, 1160, 1434, 1438, 1445, 2128, 2302, 2363, 3197, 3352, 3419, 3465, 3969, 4437, 4439, 4787, 4866, 5336, 5734], 'hallmark': [430], 'non-insulin-dependent': [432], '(type': [433], 'II)': [434], 'diabetes': [435, 445, 637], 'mellitus.': [436], 'More': [437], 'death': [455], '(1Kahn': [456], 'S.E.': [457], 'Andrikopoulos': [458], 'S.': [459, 610, 657, 691, 1217, 1248, 1285, 1472, 1615, 1663, 4250, 4380, 4594, 4667, 4694, 4793, 4855, 4887, 5407, 5545], 'Verchere': [460], 'C.B.': [461], 'Diabetes.': [462], '1999;': [463, 713, 928, 2854, 4267], '48:': [464], '241-253Crossref': [465], 'PubMed': [466, 484, 615, 662, 696, 716, 794, 825, 854, 906, 931, 975, 1000, 1050, 1106, 1193, 1222, 1253, 1277, 1307, 1326, 1361, 1462, 1488, 1505, 1545, 1637, 1668, 1894, 1979, 2013, 2572, 2651, 2832, 2857, 2900, 2918, 2967, 3048, 4230, 4255, 4270, 4385, 4616, 4672, 4699, 4728, 4815, 4840, 4860, 4892, 4936, 4961, 4984, 5071, 5119, 5300, 5366, 5412, 5437, 5567, 5749], 'Scopus': [467, 485, 616, 663, 697, 717, 795, 826, 855, 907, 932, 976, 1001, 1051, 1107, 1180, 1194, 1223, 1254, 1278, 1308, 1327, 1362, 1463, 1489, 1506, 1546, 1638, 1669, 1895, 1980, 2014, 2652, 2833, 2858, 2901, 2919, 2968, 3049, 4231, 4256, 4271, 4386, 4617, 4673, 4700, 4729, 4816, 4841, 4861, 4893, 4937, 4962, 4985, 5008, 5026, 5072, 5120, 5301, 5367, 5413, 5438, 5568, 5750], '(424)': [468], 'Google': [469, 487, 591, 618, 665, 699, 719, 737, 797, 828, 857, 909, 934, 978, 1003, 1053, 1109, 1182, 1196, 1225, 1256, 1280, 1310, 1329, 1364, 1465, 1491, 1508, 1548, 1640, 1671, 1897, 1982, 2016, 2573, 2654, 2835, 2860, 2903, 2921, 2970, 3051, 4233, 4258, 4273, 4388, 4619, 4675, 4702, 4731, 4818, 4843, 4863, 4895, 4939, 4964, 4987, 5010, 5028, 5074, 5122, 5303, 5369, 5415, 5440, 5570, 5752], 'Scholar,': [470, 592, 666, 700, 720, 798, 829, 910, 979, 1183, 1197, 1257, 1281, 1311, 1466, 1492, 2836, 2904, 4234, 4259, 4676, 4703, 4940, 4965, 5011, 5416], '2de': [471], 'Koning': [472, 668, 704], 'E.J.': [473, 669, 705, 4913], 'Bodkin': [474], 'N.L.': [475, 730, 2894], 'Hansen': [476], 'B.C.': [477], 'Clark': [478, 597, 682, 710, 899, 990, 2825, 3038, 4220], 'A.': [479, 598, 611, 658, 683, 692, 711, 786, 814, 900, 924, 991, 1218, 1249, 1259, 1664, 2826, 2850, 3039, 4221, 4251, 4381, 4668, 4695, 4822, 4856, 4888, 5408], 'Diabetologia.': [480, 712], '1993;': [481], '36:': [482], '378-384Crossref': [483], '(154)': [486], 'Scholar).': [488, 738, 858, 935, 1004, 1054, 1110, 1365, 1509, 1549, 1898, 2574, 2861, 2922, 2971, 3052, 4274, 4389, 4620, 4896, 5075], 'major': [490], 'component': [491], 'these': [493, 758, 1006, 1414, 3095, 3349, 3514, 4178, 4464, 4510, 5507, 5522], '(IAPP)': [501], '1The': [502], 'abbreviations': [503, 539], 'are:': [505, 541], 'IAPP,': [506, 542, 2761, 2946, 3806, 4554, 4788, 5161, 5186, 5613], 'polypeptide;': [509, 545], 'EM,': [510, 546], 'microscopy;': [512, 548], 'CD,': [513, 549], 'circular': [514, 550, 863], 'dichroism;': [515, 551], 'ThT,': [516, 552, 2877], 'thioflavin': [517, 553, 1082], 'T;': [518, 554], 'NMR,': [519, 555], 'nuclear': [520, 556, 1148], 'magnetic': [521, 557, 1149, 1156], 'resonance;': [522, 526, 558, 562], 'EPR,': [523, 559], 'SDSL,': [527, 563, 1386, 4083], 'site-directed': [528, 564, 1235], 'labeling;': [530, 566], 'Aβ,': [531, 567, 4625, 4755], 'β;': [533, 569], 'HFIP,': [534, 570, 2124], 'hexafluoroisopropanol;': [535, 571], 'MTSL,': [536, 572], '1-oxyl-2,2,5,5-tetramethyl-Δ3-pyrroline-3-methyl': [537, 573, 1714], 'methanethiosulfonate.1The': [538], 'methanethiosulfonate.': [574], '(3Westermark': [575], 'P.': [576, 780, 839, 1289, 1619, 2636, 4236, 4598, 4797, 5286, 5352, 5549], 'Wernstedt': [577], 'C.': [578, 831, 1043, 1315, 1538, 2628, 2890, 3451, 4244], "O'Brien": [579], 'T.D.': [580, 722], 'Hayden': [581], 'D.W.': [582], 'Johnson': [583, 4239], 'K.H.': [584, 4240], 'Am.': [585, 731, 1174, 2566, 5002, 5020], 'J.': [586, 639, 732, 818, 819, 835, 837, 843, 848, 914, 925, 969, 987, 994, 1100, 1173, 1263, 1266, 1296, 1477, 1626, 2551, 2567, 2632, 2634, 2640, 2645, 2840, 2851, 2896, 3035, 3042, 4217, 4224, 4264, 4605, 4686, 4719, 4804, 4826, 4829, 4954, 4978, 5001, 5019, 5062, 5110, 5289, 5355, 5431, 5556, 5743], 'Pathol.': [587, 733], '1987;': [588, 612], '127:': [589], '414-417PubMed': [590], '4Cooper': [593], 'G.J.': [594, 802, 845, 2563, 2642], 'Willis': [595], 'A.C.': [596, 4881], 'Turner': [599], 'R.C.': [600], 'Sim': [601], 'R.B.': [602, 4879], 'Reid': [603, 2564], 'K.B.': [604], 'Proc.': [605, 652, 686, 1212, 1243, 1658, 4245, 4375, 4662, 4689, 4850, 4882, 5402], 'Natl.': [606, 653, 687, 1213, 1244, 1659, 4246, 4376, 4663, 4690, 4851, 4883, 5403], 'Acad.': [607, 654, 688, 1214, 1245, 1660, 4247, 4377, 4664, 4691, 4852, 4884, 5404], 'Sci.': [608, 655, 689, 1215, 1246, 1661, 4248, 4378, 4665, 4692, 4853, 4885, 5405], 'U.': [609, 656, 690, 816, 847, 1216, 1247, 1662, 2644, 4238, 4249, 4379, 4666, 4693, 4854, 4877, 4886, 5406], '84:': [613], '8628-8632Crossref': [614], '(1166)': [617], 'Scholar),': [619, 2655, 4732, 4819, 4844, 4864, 5029, 5370, 5571, 5753], 'multiple': [621], 'investigation': [624], 'provided': [626], 'experimental': [627, 5759], 'evidence': [628], 'implicating': [629], 'human': [630, 1030, 1701], '(5Janson': [638], 'Soeller': [640], 'W.C.': [641], 'Roche': [642], 'P.C.': [643, 651, 724, 2892], 'Nelson': [644], 'R.T.': [645], 'Torchia': [646], 'A.J.': [647], 'Kreutter': [648, 725], 'D.K.': [649, 726], 'Butler': [650, 723, 2891], '1996;': [659, 791, 1459], '93:': [660], '7283-7288Crossref': [661], '(301)': [664], '6de': [667], 'Morris': [670, 678, 708], 'E.R.': [671], 'Hofhuis': [672], 'F.M.': [673], 'Posthuma': [674], 'G.': [675, 4969], 'Hèoppener': [676], 'J.W.': [677], 'J.F.': [679, 709], 'Capel': [680], 'P.J.': [681], 'Verbeek': [684, 706], 'J.S.': [685, 707], '1994;': [693], '91:': [694], '8467-8471Crossref': [695], '(93)': [698], '7MacArthur': [701], 'D.L.': [702], 'de': [703], '42:': [714], '1219-1227Crossref': [715], '(35)': [718], "8O'Brien": [721], 'Kane': [727], 'L.A.': [728], 'Eberhardt': [729, 2893], '1995;': [734, 1177, 4933, 5005], '147:': [735], '609-616PubMed': [736], 'diabetic': [745], 'patient': [746], 'were': [747, 760, 1695, 1749, 1782, 1791, 1801, 1813, 1828, 1856, 1901, 1946, 2022, 2035, 2086, 2110, 2137, 2156, 2174, 2209, 2236, 2293, 2307, 2319, 2341, 2348, 2361, 2380, 2391, 2414, 2446, 2456, 2488, 2697, 2745, 3158, 3336, 3607, 3613, 4369], 'first': [748], 'century': [753], 'ago,': [754], 'not': [761, 2577, 2664, 2990, 3108, 3533, 3737, 4205, 4436, 4541, 5156, 5344, 5512, 5582, 5598], 'described': [762, 2129, 2303, 2364, 5052], 'until': [763, 1820], 'recently.': [764], 'Electron': [765, 2464], 'microscopy': [766], '(EM)': [767], 'studies': [768, 940, 4647, 5154, 5721], 'revealed': [772], 'long': [776], 'structures': [778, 2872], '(9Westermark': [779], 'Li': [781], 'Z.C.': [782], 'Westermark': [783, 4241, 5285, 5351], 'G.T.': [784, 4242], 'Leckstrèom': [785], 'Steiner': [787], 'D.F.': [788], 'FEBS': [789, 901, 2827], 'Lett.': [790, 902, 2828], '379:': [792], '203-206Crossref': [793], '(162)': [796], '10Goldsbury': [799], 'C.S.': [800], 'Cooper': [801, 844, 2562, 2641], 'Goldie': [803, 832, 2629], 'K.N.': [804], 'Mèuller': [805, 840, 2637], 'S.A.': [806, 841, 2638], 'Saafi': [807], 'E.L.': [808], 'Gruijters': [809], 'W.T.': [810], 'Misur': [811], 'M.P.': [812], 'Engel': [813], 'Aebi': [815, 846, 2643], 'Kistler': [817, 842, 2639], 'Struct.': [820, 849, 1356, 1540, 2646, 4931], 'Biol.': [821, 850, 927, 971, 996, 1102, 1189, 1267, 1297, 1357, 1478, 1541, 1627, 2647, 2853, 3044, 4226, 4266, 4606, 4805, 4830, 4932, 4980, 5290, 5356, 5433, 5557, 5745], '1997;': [822, 1103], '119:': [823], '17-27Crossref': [824], '(256)': [827], '11Goldsbury': [830], 'K.': [833, 918, 1455, 2630, 2844, 2908], 'Pellaud': [834, 2631], 'Seelig': [836, 2633], 'Frey': [838, 2635], '2000;': [851, 903, 1190, 1542, 2648, 2829, 4696, 4958], '130:': [852, 2649], '352-362Crossref': [853, 2650], '(288)': [856, 2653], 'Fourier': [859], 'transform': [860], 'infrared': [861], 'dichroism': [864], '(CD)': [865], 'analysis': [866], 'made': [870], 'full-length': [872, 1383, 1775, 2624, 2680, 3113, 5185, 5243], 'well': [874, 3544], 'shorter': [876, 4898, 5148], 'fragments': [877, 4199, 4902, 5149], 'significant': [882, 3481], 'amounts': [883, 3391, 3436], 'β-sheet': [885, 2806, 5032, 5661], '(12Higham': [891, 2817], 'C.E.': [892, 983, 2818, 3031, 4213], 'Jaikaran': [893, 2819], 'E.T.': [894, 981, 2820, 3029, 4211], 'Fraser': [895, 992, 1094, 2821, 3040, 4222], 'P.E.': [896, 993, 1095, 2822, 3041, 4223], 'Gross': [897, 988, 2823, 3036, 4218], 'M.': [898, 989, 1089, 1093, 1168, 1240, 1283, 1317, 1468, 1613, 2824, 2910, 3037, 4219, 4372, 4592, 4791, 4847, 4915, 4996, 5015, 5543], '470:': [904, 2830], '55-60Crossref': [905, 2831], '(108)': [908, 2834], '13Kayed': [911, 2837], 'R.': [912, 1185, 1211, 1242, 1265, 1287, 1295, 1353, 1474, 1476, 1496, 1617, 1625, 1657, 2838, 4374, 4596, 4604, 4688, 4717, 4795, 4803, 4828, 4849, 4956, 4977, 5058, 5106, 5288, 5354, 5401, 5430, 5547, 5555], 'Bernhagen': [913, 2839], 'Greenfield': [915, 2841], 'N.': [916, 2842], 'Sweimeh': [917, 2843], 'Brunner': [919, 2845], 'H.': [920, 2846, 2906, 4655], 'Voelter': [921, 2847], 'W.': [922, 2848], 'Kapurniotu': [923, 2849], 'Mol.': [926, 970, 995, 1101, 2852, 3043, 4225, 4265, 4979, 5432, 5744], '287:': [929, 2855], '781-796Crossref': [930, 2856], '(314)': [933, 2859], 'X-ray': [936], 'diffraction': [939], 'using': [941, 1138, 1610, 1755, 1862, 1941, 1959, 2047, 2179, 2217, 2309, 2350, 2448, 2459, 2876, 3668, 4004], 'aligned': [942], 'shown': [945, 3445, 3877], 'chains': [949, 1517], 'arranged': [951, 1562], 'cross-β-conformation': [954], 'individual': [957, 4740], 'β-strands': [958], 'perpendicular': [959], 'fibril': [962, 2135, 2289, 2596, 2677, 2739, 2784, 2925, 3026, 3069, 3074, 3935, 4208, 5601, 5642], 'axis': [963], '(14Sumner': [964], 'Makin': [965], 'O.': [966], 'Serpell': [967, 984, 1090, 3032, 4214], 'L.C.': [968, 985, 1091, 3033, 4215], '2004;': [972, 1250, 1358, 4382, 4857, 4889, 4981, 5063, 5111, 5292, 5358, 5434], '335:': [973, 4982, 5435], '1279-1288Crossref': [974], '(130)': [977], '15Jaikaran': [980], 'Higham': [982, 3030, 4212], 'Zurdo': [986, 3034, 4216], '2001;': [997, 1323, 1480, 3045, 4227, 5746], '308:': [998, 3046, 4228, 5747], '515-525Crossref': [999, 3047, 4229], '(215)': [1002, 3050, 4232], 'Beyond': [1005], 'observations,': [1007], 'little': [1008], 'known': [1010, 2880], 'about': [1011], 'molecular': [1013, 1129, 1679, 1805, 1860, 3135, 3803], 'details': [1014, 3800], 'form.': [1020, 3487, 3816, 4079, 5445, 5681, 5771], 'Amyloid': [1021], 'number': [1028, 2214], 'diseases,': [1031], 'such': [1032, 1073, 1142, 1159, 4786, 5733], "Parkinson's": [1036], 'familial': [1039], 'amyloidotic': [1040], 'polyneuropathy': [1041], '(16Soto': [1042], 'Nat.': [1044, 1539, 4930], 'Rev.': [1045], 'Neurosci.': [1046], '2003;': [1047, 1269, 4832], '4:': [1048, 1191], '49-60Crossref': [1049], '(1084)': [1052], 'primary': [1057, 5269], 'forming': [1061], 'proteins': [1062, 1133, 1343], 'varies': [1063], 'widely,': [1064], 'most': [1065, 1553, 3940, 5585], 'appear': [1068], 'share': [1070], 'common': [1071, 4779], 'characteristics,': [1072], 'cross-β-structure,': [1076], 'ability': [1079, 2863, 3111], 'bind': [1081, 2882], 'T': [1083], '(ThT)': [1084], 'Congo': [1086], 'red': [1087, 3261], '(17Sunde': [1088], 'Bartlam': [1092], 'Pepys': [1096], 'M.B.': [1097], 'Blake': [1098], 'C.C.': [1099, 1261, 4824], '273:': [1104], '729-739Crossref': [1105], '(1409)': [1108], 'Because': [1111], 'non-crystalline': [1114], 'insoluble': [1116], 'nature': [1117], 'it': [1121, 2592, 3009, 4756, 5649], 'has': [1122, 5050], 'difficult': [1124, 4468], 'obtain': [1126, 1336, 1379, 3131, 3798], 'detailed': [1128], 'amyloidogenic': [1132, 1342], 'conventional': [1139], 'biophysical': [1140], 'techniques': [1141], 'x-ray': [1144], 'crystallography': [1145], 'solution-state': [1147], '(NMR)': [1151], 'spectroscopy.': [1152, 1673, 2367], 'other': [1155], 'techniques,': [1158], 'solid-state': [1161, 4645], 'NMR': [1162, 1643, 4646], '(18Griffiths': [1163, 4991], 'J.M.': [1164, 1494, 4911, 4992], 'Ashburn': [1165, 4922, 4993], 'T.T.': [1166, 4923, 4994, 5013], 'Auger': [1167, 4914, 4995, 5014], 'Costa': [1169, 4908, 4997], 'P.R.': [1170, 4909, 4998], 'Griffin': [1171, 4928, 4999], 'R.G.': [1172, 4925, 4929, 5000], 'Chem.': [1175, 1188, 1268, 1298, 1479, 1628, 4607, 4806, 4831, 5003, 5021, 5291, 5357, 5558], 'Soc.': [1176, 5004, 5022], '117:': [1178, 5006], '3539-3546Crossref': [1179, 5007], '(128)': [1181, 5009], '19Tycko': [1184], 'Curr.': [1186, 1354], 'Opin.': [1187, 1355], '500-506Crossref': [1192], '(86)': [1195], '20Petkova': [1198], 'A.T.': [1199, 1645, 4707, 4967, 5389], 'Ishii': [1200, 1646, 4943, 5390], 'Y.': [1201, 1647, 4944, 5391, 5428], 'Balbach': [1202, 1648, 4679, 5055, 5103, 5392], 'J.J.': [1203, 1649, 4680, 4705, 4942, 5056, 5104, 5393], 'Antzutkin': [1204, 1650, 4710, 4945, 5394], 'O.N.': [1205, 1651, 4678, 4711, 4946, 5395], 'Leapman': [1206, 1652, 4681, 4947, 4972, 5396], 'R.D.': [1207, 1653, 4682, 4948, 4973, 5397], 'Delaglio': [1208, 1654, 5398], 'F.': [1209, 1655, 4952, 4971, 5399], 'Tycko': [1210, 1656, 4687, 4716, 4955, 4976, 5057, 5105, 5400], '2002;': [1219, 1299, 1502, 1629, 1665, 1891, 1976, 2964, 4608, 4720, 4807, 5409, 5559], '99:': [1220, 1666, 5410], '16742-16747Crossref': [1221, 1667, 5411], '(1635)': [1224, 1670, 5414], 'Scholar)': [1226, 1330, 1641, 1672, 1983, 4988, 5123, 5304, 5441], '(EPR)': [1231], 'together': [1233, 3088, 4642], 'labeling': [1237], '(SDSL)': [1238], '(21Margittai': [1239, 4371, 4846], 'Langen': [1241, 1264, 1294, 1475, 1495, 1624, 4373, 4603, 4802, 4827, 4848, 5554], '101:': [1251, 4383, 4858, 4890], '10278-10283Crossref': [1252, 4384, 4859], '(239)': [1255, 4387, 4862], '22Der-Sarkissian': [1258], 'Jao': [1260, 4823], 'Chen': [1262, 4825], '278:': [1270, 4833], '37530-37535Abstract': [1271, 4834], 'Full': [1272, 1274, 1302, 1304, 1483, 1485, 1632, 1634, 4611, 4613, 4723, 4725, 4810, 4812, 4835, 4837, 5066, 5068, 5114, 5116, 5295, 5297, 5361, 5363, 5562, 5564], 'Text': [1273, 1275, 1303, 1305, 1484, 1486, 1633, 1635, 4612, 4614, 4724, 4726, 4811, 4813, 4836, 4838, 5067, 5069, 5115, 5117, 5296, 5298, 5362, 5364, 5563, 5565], 'PDF': [1276, 1306, 1487, 1636, 4615, 4727, 4814, 4839, 5070, 5118, 5299, 5365, 5566], '(289)': [1279, 4842], '23Torok': [1282], 'Milton': [1284, 1614, 4593, 4792, 5544], 'Kayed': [1286, 1616, 4595, 4794, 5546], 'Wu': [1288, 1618, 4597, 4796, 5548], 'McIntire': [1290, 1620, 4599, 4798, 5550], 'T.': [1291, 1621, 2912, 4600, 4799, 5551], 'Glabe': [1292, 1622, 4601, 4800, 5552], 'C.G.': [1293, 1623, 4602, 4801, 5553], '277:': [1300, 1630, 4609, 4808, 5560], '40810-40815Abstract': [1301, 1631, 4610, 4809, 5561], '(340)': [1309, 1639, 4618, 4817, 5569], '24Serag': [1312], 'A.A.': [1313], 'Altenbach': [1314, 1537], 'Gingery': [1316], 'Hubbell': [1318, 1456, 1499], 'W.L.': [1319, 1457, 1500, 1534], 'Yeates': [1320], 'T.O.': [1321], 'Biochemistry.': [1322, 1458, 1501, 1890, 1975, 2963, 4957], '40:': [1324], '9089-9096Crossref': [1325], '(67)': [1328], 'successfully': [1334], '(for': [1348], 'review,': [1349], 'see': [1350, 1408], 'Ref.': [1351], '25Tycko': [1352], '14:': [1359], '96-103Crossref': [1360], '(350)': [1363], 'present': [1368, 2585, 4476, 4573], 'study,': [1369], 'we': [1370, 2688, 2762, 2947, 3054, 3146, 3328, 3563, 3672, 3718, 3807, 4084, 4123, 4446, 4495, 4512, 4626, 5490, 5510, 5591, 5707], 'EPR': [1372, 1411, 1522, 2131, 2133, 2172, 3120, 3187, 3302, 3408, 3463, 3565, 3791, 3793, 3846, 3864, 3892, 4081, 4360, 4405, 4631, 4640, 4750, 5683], 'combination': [1375], 'SDSL': [1377, 4348], 'IAPP.': [1384, 3345, 3394, 3678, 3741, 4136, 4769, 5199], 'cysteine-specific': [1388], 'nitroxide': [1389], 'introduced': [1393], 'at': [1394, 1817, 1839, 1951, 2024, 2069, 2176, 2193, 2324, 2382, 2387, 2393, 2418, 2451, 2721, 2769, 2780, 2930, 2935, 3160, 3274, 3635, 3690, 3724, 3907, 3942, 4293, 4523, 4549, 5373, 5525], 'selected': [1395, 3161], 'sites': [1396, 3162, 3638, 3654, 3667, 3916, 3943, 3961, 3984, 4033, 4053, 4059, 4115, 4429, 4525, 4552, 5535], 'protein': [1399], 'molecule,': [1400], 'resulting': [1401], 'nitroxide-labeled': [1404], 'side': [1405, 1516], 'chain': [1406], '(R1,': [1407], 'Fig.': [1409, 3200, 3447, 3679, 3879], '1).': [1410], 'R1': [1415, 1515, 3218, 3292, 3367, 3540, 3812, 3874, 3906, 3999, 4127, 4300, 4413, 4458], 'reporter': [1416], 'groups': [1417], 'reflect': [1418], 'local': [1420], 'environment': [1421], 'can': [1426, 1518, 2542, 3505, 3556, 4001, 5334, 5622], 'be': [1427, 1519, 1687, 3387, 4002, 4341, 4487, 4521, 4776], 'classify': [1430], 'given': [1432, 1524, 3372, 4307, 4745, 5263], 'site': [1433, 1449, 3929, 4304, 4316, 5517], 'loop': [1436], 'region,': [1437, 4171, 4434, 5323], 'exposed': [1440], 'or': [1441, 1444, 2120, 2188, 5319, 5736], 'buried': [1442], 'site,': [1443], 'tertiary': [1447], 'contact': [1448, 3757, 4456], '(26McHaourab': [1450], 'H.S.': [1451], 'Lietzow': [1452], 'M.A.': [1453], 'Hideg': [1454], '35:': [1460], '7692-7704Crossref': [1461], '(527)': [1464], '27Margittai': [1467], 'Fasshauer': [1469], 'D.': [1470], 'Pabst': [1471], 'Jahn': [1473], '276:': [1481], '13169-13177Abstract': [1482], '(101)': [1490], '28Isas': [1493], 'Haigler': [1497], 'H.T.': [1498], '41:': [1503, 1892, 1977, 2965], '1464-1473Crossref': [1504], '(100)': [1507], 'Furthermore,': [1510, 5326, 5590], 'distance': [1512], 'between': [1513, 1530, 2343, 3889, 3952, 4034, 4457, 4748, 5249, 5267, 5632], 'two': [1514, 2537, 2660, 2684, 3064, 3103, 3751, 4051, 4366, 5483, 5523], 'estimated': [1520], 'spectra,': [1523, 3901], 'interactions': [1529, 3296, 3317, 3401, 3649, 3824, 4168, 4629], 'labels': [1532, 3293, 4402, 4414, 4459], '(29Hubbell': [1533], 'Cafiso': [1535], 'D.S.': [1536], '7:': [1543], '735-739Crossref': [1544], '(718)': [1547], 'find': [1551, 5592], 'regions': [1554, 3172, 4134, 5715, 5738], 'its': [1558, 4077, 5133, 5794], 'fashion': [1567], 'different': [1573, 2936, 3171], 'strands': [1574, 4568, 4741], 'another,': [1580, 3926], 'indicating': [1581, 3617, 3643, 3902, 5572], 'similar': [1600, 2619, 2954, 2988, 3073, 3520, 3559, 4579, 4762, 5383, 5534, 5625], 'observed': [1603, 2763, 2948, 2976, 3072, 3719, 3738, 3835, 3959, 4124, 4277, 4370, 4419, 4627, 4637, 5266, 5491], 'Aβ': [1606, 1684, 4589, 4789, 4904, 5252, 5274, 5332, 5387, 5446, 5461, 5541], 'obtained': [1609, 1696, 1704, 1718, 1731, 2157, 2175, 2294, 2308, 2415, 3321, 3427, 3470, 3523, 3564, 3603, 4003, 4582, 5532], 'EPR/SDSL': [1611, 5666, 5720], '(23Torok': [1612, 4591, 4790, 5542], '(20Petkova': [1644, 5388], 'suggest': [1676, 3537], 'architecture': [1680, 3136], 'could': [1686, 3018, 4486, 4520, 5253, 5379], 'related.': [1688], 'Chemicals': [1689, 1722], 'Peptides—Hexafluoroisopropanol': [1691], '(HFIP)': [1692], 'ThT': [1694, 2358, 2374, 2692, 2927, 2951, 2979, 3007, 3093], 'Sigma-Aldrich.': [1698], 'Synthetic': [1699, 2600], 'wild-type': [1700, 1969, 2118, 2703, 2758, 2865, 2943, 3078, 3438, 3527, 3581, 5608, 5640], 'was': [1703, 1717, 1730, 1753, 1844, 1929, 1939, 2045, 2059, 2065, 2263, 2375, 2471, 2480, 2515, 2873, 2933, 3736, 3939, 3958, 4068, 4116, 4287, 5314], 'Bachem': [1706], '(King': [1707], 'Prussia,': [1709], 'PA).': [1710], 'label,': [1713, 1728], 'methanethiosulfonate': [1715], '(MTSL),': [1716], 'Toronto': [1720], 'Research': [1721], '(Toronto,': [1723], 'Canada).': [1724], 'thiol-reactive': [1726], 'pyrene': [1727, 3689, 3731, 3765, 3776, 4329, 4335, 4560], 'N-(1-pyrenyl)maleimide,': [1729], 'Molecular': [1733], 'Probes': [1734], '(Eugene,': [1735], 'OR).': [1736], 'An': [1737], 'analog': [1738, 2107, 3433, 3676], 'containing': [1741, 2750, 5193], 'no': [1742], 'cysteine': [1743, 1771, 2002, 2539, 2686, 3105, 3150, 3595], '(wherein': [1745], 'native': [1747, 2538, 2625, 2661, 2685, 3065, 3104], 'cysteines': [1748, 2662, 3066, 5596], 'replaced': [1750], 'by': [1751, 1793, 1807, 1846, 1948, 2092, 2482, 2533, 2679, 3237, 3873, 3971, 4325], 'alanine)': [1752], 'synthesized': [1754], 'fluorenyl-9-methoxycarbonyl': [1756], 'chemistry': [1757], 'automatic': [1760], 'synthesizer': [1762], '(ABI': [1763], '433A,': [1764], 'Applied': [1765], 'Biosystems,': [1766], 'Foster': [1767], 'City,': [1768], 'CA).': [1769, 1788], 'Single': [1770], 'substituted': [1772], 'mutants': [1773], 'based': [1777], 'our': [1779, 3090, 3490, 3790, 4160, 4326, 4478, 4584, 4749, 5665], 'cysteine-less': [1780, 1990, 2121, 2705, 2760, 2867, 3080, 3114, 5606], 'template': [1781], 'purchased': [1783], 'Synpep': [1785], 'Corp.': [1786], '(Dublin,': [1787], 'Crude': [1789], 'purified': [1792, 1826], 'reverse': [1794, 1847, 1917], 'phase': [1795, 1848, 1918], 'pressure': [1797, 1850], 'liquid': [1798, 1851, 2254], 'chromatography': [1799], 'characterized': [1802, 1857], 'correct': [1804, 1859], 'weight': [1806, 1861], 'electrospray': [1808, 1863], 'mass': [1809, 1864], 'spectrometry.': [1810, 1865], 'Purified': [1811, 1899], 'lyophilized': [1814, 2257, 2261], 'stored': [1816, 2023], '-70': [1818, 2025], '°C': [1819], 'further': [1821, 4323], 'use.': [1822], 'For': [1823, 2099, 2439, 2756, 2941, 4897, 5481], 'labeling,': [1825], 'reacted': [1829], '3-fold': [1831], 'molar': [1832], 'excess': [1833, 2502], 'MTSL': [1835, 1843], '∼1': [1837], 'h': [1838], 'room': [1840, 2070, 2177, 2394], 'temperature.': [1841], 'Unreacted': [1842], 'removed': [1845, 2481], 'chromatography,': [1852], 'Preparation': [1866], 'Peptide': [1868, 1944], 'Stock': [1869, 2018], 'Solutions—We': [1870], 'prepared': [1871, 2362], 'stock': [1873, 2031, 2232], 'solutions': [1874, 2019, 2032, 2233, 2274, 2355], 'under': [1875, 2547, 5375], 'conditions': [1876, 2549, 5377], 'reproducibly': [1879], 'generate': [1880, 5757], 'unstructured,': [1881], 'monomeric': [1882, 3696, 3740], 'forms': [1883, 5618], '(30Padrick': [1886, 1971, 2959], 'S.B.': [1887, 1972, 2960, 5740], 'Miranker': [1888, 1973, 2961, 5741], 'A.D.': [1889, 1974, 2962, 5284, 5350, 5418, 5742], '4694-4703Crossref': [1893, 1978, 2966], '(284)': [1896, 1981, 2969], 'dissolved': [1902, 2264, 2300, 2698], '6': [1904, 1955, 5212], 'm': [1905, 1956], 'guanidine': [1906, 1957], 'HCl': [1907, 1958], 'loaded': [1909], 'onto': [1910, 2473], 'column': [1913, 1928], 'packed': [1914], 'C18': [1916], 'separation': [1919, 3888, 5225], 'media': [1920], '(Harvard': [1921], 'Apparatus,': [1922], 'Holliston,': [1923], 'MA).': [1924], 'After': [1925, 2500], 'loading,': [1926], 'washed': [1930], 'once': [1931], 'deionized': [1933, 2248, 2512], 'distilled': [1934, 2249, 2511], 'water,': [1935, 2250, 2513], 'eluted': [1940], '100%': [1942], 'HFIP.': [1943], 'concentrations': [1945], 'calculated': [1947], 'UV': [1949, 2709, 2742], 'absorbance': [1950], '280': [1952], 'nm': [1953, 2323, 2384, 2782, 2932, 3726], 'extinction': [1961, 1995], 'coefficient': [1962, 1996], '1400': [1964], 'm-1': [1965, 1986, 1999], 'cm-1': [1966, 1987, 2000], '1160': [1985], '(based': [1992], '120': [1998], '(31Gill': [2003], 'S.C.': [2004, 4661, 4715, 5060, 5108], 'von': [2005], 'Hippel': [2006], 'P.H.': [2007], 'Anal.': [2008, 2913], 'Biochem.': [2009, 2895, 2914], '1989;': [2010, 2915], '182:': [2011], '319-326Crossref': [2012], '(5034)': [2015], 'Scholar)).': [2017], 'HFIP': [2021, 2034, 2044, 2109, 2235], '°C.': [2026], 'Fibril': [2027, 2063, 2531], 'Formation—Aliquots': [2028], 'pipetted': [2036, 2237], 'into': [2037, 2139, 2238, 2280, 3133, 3376], '1.5': [2038, 2239], 'ml': [2039, 2240], 'Eppendorf': [2040, 2241], 'tubes,': [2041, 2242], 'evaporated': [2046], 'speed': [2049], 'vac': [2050], 'system': [2051], '(Savant': [2052], 'Instruments,': [2053, 2164], 'Halbrook,': [2054], 'NY).': [2055], 'dry': [2057, 2260], 'redissolved': [2060], 'buffer.': [2062, 2098], 'formation': [2064, 2597, 2668, 2678, 2785, 2983, 3027, 3705, 4209, 5643, 5658], 'allowed': [2066, 5669], 'proceed': [2068], 'temperature': [2071, 2178, 2395], 'minimum': [2074, 2768], '3': [2076, 2189, 2498], 'days.': [2077], 'At': [2078, 3856], 'end': [2080], 'incubation': [2083], 'period,': [2084], 'separated': [2087], 'any': [2089], 'smaller': [2090], 'aggregates': [2091, 2752, 3708], 'centrifugation': [2093], 'repeated': [2095, 2516], 'washing': [2096, 2506], 'spin-dilution': [2100], 'experiments,': [2101], 'aliquots': [2102, 2229], 'each': [2104, 2369, 3927, 4303], 'R1-labeled': [2105, 3147, 3179, 3207, 3325, 3342, 3357, 3501, 3554, 3578, 3593, 3666, 3915], 'mixed': [2111, 2243], 'appropriate': [2114, 2351], 'amount': [2115, 4155, 4473], 'either': [2117], 'formed': [2127, 3512, 3569, 3745, 5694], 'above.': [2130, 2304], 'Spectroscopy—For': [2132, 2226], 'spectroscopy,': [2134, 2228], 'suspensions': [2136, 2290], 'taken': [2138, 2320], 'quartz': [2140, 2284], 'capillaries': [2141], '(0.6': [2142], 'mm': [2143, 2148, 2267], 'inner': [2144], 'diameter': [2145], '×': [2146], '0.84': [2147], 'outer': [2149, 3891, 4367, 4426], 'diameter,': [2150], 'VitroCom,': [2151], 'Mt.': [2152], 'Lakes,': [2153], 'NJ).': [2154], 'Spectra': [2155, 2208, 2286, 3121, 3303, 3452, 3794], 'Bruker': [2160], 'EMX': [2161], 'spectrometer': [2162], '(Bruker': [2163], 'Billerica,': [2165], 'MA)': [2166], 'fitted': [2167], 'ER4123D': [2170], 'resonator.': [2171], 'field': [2181], 'modulation': [2182], 'amplitude': [2183, 3258, 3834, 3975], '1': [2185, 2336, 2403, 2434, 2518], '(solution': [2186], 'spectra)': [2187, 2191], '(fibrillar': [2190], 'gauss': [2192], 'incident': [2195], 'microwave': [2196], 'power': [2197], '12': [2199], 'mW': [2200], 'scan': [2203, 2326, 2422], 'range': [2204], '150': [2206], 'gauss.': [2207], 'normalized': [2210, 2447], 'spins': [2216], 'double': [2219], 'integral': [2220], 'presented': [2223], 'accordingly.': [2224], 'CD': [2225, 2227, 2305, 2366, 2690, 2710, 2743, 3091, 3238], '500': [2245], 'μl': [2246, 2466, 2492, 2509, 2522], 'immediately': [2251], 'frozen': [2252], 'nitrogen,': [2255], 'overnight.': [2258], '10': [2266, 2405, 5209], 'phosphate': [2268, 2700], 'buffer': [2269, 2292], 'yield': [2271], '25': [2272, 2372], 'μm': [2273, 2373], 'prior': [2275], 'use': [2277], 'transferred': [2279], '1-mm': [2282], 'path-length': [2283], 'cell.': [2285], 'grown': [2297, 3337], 'freshly': [2299], 'Jasco': [2311, 2461], '815': [2312], 'spectropolarimeter': [2313], '(Jasco,': [2314], 'Inc.,': [2315], 'Easton,': [2316], 'MD).': [2317], 'Measurements': [2318, 2390], 'every': [2321, 5515], '0.5': [2322], 'rate': [2327, 2423], '50': [2329], 'nm/min': [2330], 'averaging': [2333], 's.': [2337], 'Typically,': [2338], '20–50': [2339], 'scans': [2340], 'averaged': [2342], '190–260': [2344], 'nm.': [2345, 2389, 2453, 2723], 'All': [2346, 3601], 'corrected': [2349], 'backgrounds.': [2352], 'Fluorescence': [2353, 2454], 'Spectroscopy—Fibril': [2354], 'binding': [2359], 'assay': [2360], 'To': [2368, 2674, 2733, 2923, 3263, 3660, 4489], 'fibrillization': [2370], 'reaction,': [2371], 'added': [2376], 'emission': [2378, 2399, 2430, 2441, 2928, 2952, 3683, 3722], 'intensities': [2379], 'measured': [2381, 2934], '482': [2383, 2931], 'excitation': [2386, 2397, 2417, 2428], '450': [2388], 'performed': [2392, 5159], 'slit': [2400, 2431], 'widths': [2401, 2432, 4025], 'nm,': [2406, 2420, 2437, 2771], 'respectively.': [2407, 2438], 'Emission': [2408], 'pyrene-labeled': [2411, 2444, 3675], '350': [2419], '100': [2425, 3610], 'nm/min,': [2426], '5': [2436, 2491, 2508, 2521], 'comparison,': [2440], 'peak': [2450], '395': [2452], 'measurements': [2455], 'carried': [2457, 3329], 'out': [2458, 3330], 'FP-6500': [2462], 'spectrofluorometer.': [2463], 'Microscopy—5–10': [2465], 'solution': [2470, 3183, 3699, 3900, 4097], 'adsorbed': [2472], 'glow-discharged': [2474], 'carbon-coated': [2475], 'copper': [2476], 'grids.': [2477], 'Excess': [2478], 'sample': [2479, 3167], 'blotting': [2483, 2501], 'filter': [2485], 'paper.': [2486], 'Grids': [2487], 'stained': [2489], '3%': [2494], 'uranyl': [2495, 2503, 2523], 'acetate': [2496, 2504], 'min.': [2499], 'staining': [2514], 'min': [2519], 'acetate.': [2524], 'Native': [2525], 'Cysteines': [2526, 3157], 'Are': [2527], 'Not': [2528], 'Required': [2529], 'Formation': [2532], 'Full-length': [2534], 'IAPP—IAPP': [2535], 'contains': [2536, 5447], 'disulfide': [2545, 5630], 'bridge': [2546], 'oxidizing': [2548], '(32Cornish': [2550], 'Callon': [2552], 'K.E.': [2553], 'Lin': [2554], 'C.Q.': [2555], 'Xiao': [2556], 'C.L.': [2557], 'Mulvey': [2558], 'T.B.': [2559], 'Coy': [2560], 'D.H.': [2561], 'I.R.': [2565], 'Physiol.': [2568], '1998;': [2569, 2897, 4669], '274:': [2570], 'E827-E833Crossref': [2571], 'It': [2575, 4466], 'clear,': [2578], 'however,': [2579, 5030], 'whether': [2580, 2591, 2676, 3059], 'link': [2582, 5631], 'always': [2584], 'state': [2589, 3730], 'and/or': [2590, 3297, 3622], 'required': [2594, 4206, 5599], 'vivo.': [2599], 'lacking': [2602, 4362], 'seven': [2605], 'morphology': [2618, 3519], '(11Goldsbury': [2627], 'which': [2656, 3476, 3735, 5214], 'necessary': [2665], 'vitro.': [2673], 'requires': [2682, 4393], 'residues,': [2687, 5211], 'binding.': [2693], 'Immediately': [2694], 'after': [2695, 3703], 'they': [2696], 'buffer,': [2701], 'both': [2702, 2757, 2942, 2973], 'produced': [2707], 'far': [2708, 2741], '(Fig.': [2712, 2786, 2939, 3082, 3239, 3259, 3277, 3599, 3631, 3988, 5276], '2,': [2713, 2787, 3083], 'A': [2714, 2788, 3991], 'B,': [2716, 2790], 'solid': [2717], 'lines)': [2718, 3634], 'minima': [2720], '∼200': [2722], 'unordered': [2730, 2803, 3234], 'backbone': [2731], 'structure.': [2732, 5662], 'observe': [2734], 'changes': [2736, 2794, 3494], 'formation,': [2740, 2926, 5602], 'collected': [2746], 'aged': [2748], 'samples': [2749, 3455, 3589, 3606, 3630], '(see': [2753, 3154, 3658], 'EM': [2754, 3056], 'below).': [2755], 'reduction': [2765, 3299, 4283], '200': [2770], 'concomitant': [2774], 'increase': [2775], 'negative': [2778], 'ellipticity': [2779], '∼220': [2781], 'upon': [2783, 3495, 3934, 4509, 5704], 'dotted': [2791], 'lines).': [2792], 'conformational': [2799, 5646], 'change': [2800], 'agreement': [2811, 3231, 3785], 'published': [2813], 'also': [2874, 4766, 5173, 5254], 'monitored': [2875], 'dye': [2879], 'strongly': [2883], '(33Kudva': [2887], 'Y.C.': [2888], 'Mueske': [2889], '331:': [2898], '809-813Crossref': [2899], '(57)': [2902], '34Naiki': [2905], 'Higuchi': [2907], 'Hosokawa': [2909], 'Takeda': [2911], '177:': [2916], '244-249Crossref': [2917], '(979)': [2920], 'monitor': [2924], 'intensity': [2929, 2953, 2980, 4424], 'points': [2938, 5166], '2C).': [2940], 'cysteineless': [2945, 3442], 'increases': [2949, 2977], 'those': [2956, 4581, 4636, 5531], 'reported': [2957], 'previously': [2958], 'cases,': [2974], 'indicate': [2981, 3821, 4013, 4131], '(yet': [2989], 'identical)': [2991], 'kinetics.': [2992], 'subtle': [2995], 'difference': [2996], 'kinetics': [2998, 3024], 'inherent': [3003], 'variability': [3004], 'assay,': [3008], 'possible': [3011, 4455], 'conformation': [3015], 'make': [3019], 'minor': [3020], 'contributions': [3021], '(15Jaikaran': [3028, 4210], 'Next,': [3053, 3562], 'test': [3058, 3311], 'absence': [3061, 3100, 3473, 3842], 'influenced': [3067], 'morphology.': [3070], 'morphologies': [3075], 'D': [3084], 'E).': [3086], 'Taken': [3087], 'data,': [3094, 3531, 4641], 'imply': [3097], 'does': [3107], 'alter': [3109], 'fibrils.': [3119, 5183, 5246, 5718], 'Soluble': [3123], 'Fibrillar': [3125], 'Forms': [3126], 'Spin-labeled': [3128, 3305], 'Analogs—To': [3130], 'insight': [3132], 'monomers': [3139, 3752], 'soluble': [3142, 3245], 'forms,': [3145], 'single': [3149, 3594, 5516], 'analogs': [3151, 3181, 3596], '"Experimental': [3155], 'Procedures").': [3156], 'placed': [3159], 'sequence': [3165, 5165, 5270, 5308], 'information': [3169, 3850], 'narrow': [3194, 3980], 'spectral': [3195, 3211, 3252, 3267, 3282, 3412, 3458, 3493, 3641, 3829, 3896, 3981, 4497], 'width,': [3196, 4009], 'illustrated': [3198], '3A': [3201], '(black': [3202, 3700, 3881], 'line)': [3203], 'representative': [3206], 'position': [3208, 3693], '21.': [3209], 'mobile': [3217], 'rotational': [3222], 'correlation': [3223], 'scale': [3229], 'indicated': [3236, 3970], '2A).': [3240], 'contrast': [3242], 'form,': [3246, 4122], 'broadening': [3253, 3830], 'very': [3255, 4100, 5528], 'low': [3256, 3615, 3832], 'signal': [3257, 3833, 3974], '3A,': [3260, 3278], 'line).': [3262, 3280, 3710], 'assist': [3264], 'visualizing': [3266], 'features,': [3268], 'spectrum': [3271, 3469], 'plotted': [3273], '×10': [3275], 'magnification': [3276], 'green': [3279], 'could,': [3287], 'principle,': [3289], 'arise': [3290], 'experiencing': [3294], 'mobility.': [3301, 3875, 4015, 4157], 'Co-mixed': [3307], 'Unlabeled': [3309], 'Peptide—To': [3310], 'derivatives,': [3327], 'dilution': [3332, 3396, 3497, 3819, 3859], 'experiments': [3333, 3350, 3516, 3820], 'wherein': [3334, 4010, 5690], 'mixture': [3340], 'unlabeled': [3344, 3355, 3393, 3503, 3580, 3861], 'rationale': [3347], 'follows:': [3353], 'If': [3354, 5628], 'co-mix': [3359, 3506, 5610], 'fibril,': [3362, 3547], 'likelihood': [3364, 5574], 'located': [3369, 3944, 4181], 'molecule': [3374, 3385], 'coming': [3375], 'another': [3380], 'will': [3386], 'increasing': [3390, 3435], 'Spin': [3395], 'should,': [3397], 'therefore,': [3398], 'reduce': [3399], 'turn': [3404, 5737], 'give': [3405], 'width': [3413, 3459, 4040], 'sharper': [3418, 3462], 'compared': [3420, 3466, 3898], 'undiluted': [3424, 3486, 3571, 3605], 'samples.': [3425], 'Results': [3426], 'diluting': [3429], '21R1': [3432], 'derivative': [3443], '3,': [3448], 'B': [3449], 'spin-diluted': [3454, 3575, 3884], 'show': [3456], 'contain': [3461, 5208], 'dilution,': [3475], 'coupling': [3483, 4292, 4548], 'addition,': [3489], 'observation': [3491, 4161, 4327, 4558], 'because': [3510], 'co-mixing': [3515], 'alone': [3529], '(EM': [3530], 'shown).': [3534, 4542], 'tolerated': [3543], 'cysteine-less,': [3551], 'wild-type,': [3552], 'take': [3557, 5623], 'up': [3558, 4531, 5624], 'structures.': [3561, 5627], '(100%': [3572], 'R1-labeled)': [3573], '(at': [3576], 'ratio': [3584], '1:4,': [3586], '80%': [3587], 'dilution)': [3588], '4).': [3600], 'broadened': [3608], 'beyond': [3609], 'G': [3611], 'amplitude,': [3616, 3642], 'immobilization': [3621, 3904, 3938, 3957, 4056], 'diluted': [3629], '4,': [3632, 3989], 'black': [3633], 'showed': [3639, 3886], 'increased': [3640, 3887], 'existence': [3645], 'molecules': [3657, 3777, 3919, 4336, 4462], '"Discussion").': [3659], 'confirm': [3661], 'independent': [3670], 'approach,': [3671], 'employed': [3673], '3D': [3680], 'shows': [3681], 'labeled': [3687, 3928, 4355, 5612], '21': [3692], 'line),': [3701], '(red': [3709], 'case': [3713, 4442, 4623], 'sample,': [3717], 'broad': [3721, 3895], 'band': [3723], '∼472': [3725], 'excited': [3729], 'dimer': [3732], '(excimer)': [3733], 'emission,': [3734], 'Pyrene': [3742], 'excimers': [3743], 'precise': [3748, 4472], 'stacking': [3749, 4411], 'physical': [3756, 4343], 'proper': [3759], 'orientation.': [3760], 'Therefore,': [3761, 4744], 'occurrence': [3763], 'excimer': [3766, 4330, 4561], 'fluorescence': [3767, 4331], 'interpretation': [3788, 4192, 4321], 'data.': [3792], 'Spin-diluted': [3796], 'Fibrils—To': [3797], 'additional': [3799, 5727], 'analyzed': [3808], 'significantly': [3825, 4117], 'contribute': [3826], 'spectra.': [3839], 'interactions,': [3845], 'line': [3847, 4008, 4024, 4039, 5493], 'shapes': [3848], 'provide': [3849], 'dynamics': [3853], 'R1.': [3855], 'sufficiently': [3857], 'spin-labeled,': [3867], 'determined': [3871], 'As': [3876], '4': [3880], 'lines),': [3882], 'sites.': [3910, 4465, 5508], 'Thus,': [3911, 4543], 'addition': [3913, 4280], 'being': [3920], 'became': [3930], 'much': [3931, 4777], 'formation.': [3936], 'This': [3937, 4191, 4320], 'pronounced': [3941, 4166, 4438, 5454], 'central': [3947, 4007, 4141, 4184, 5321, 5449], '(sites': [3951], '12–29).': [3954], 'Slightly': [3955], 'N': [3964, 5474, 5520, 5538, 5577], 'terminus': [3965, 5080, 5475, 5539, 5578], 'larger': [3973, 4011], '2R1': [3985, 4019, 5487], '7R1': [3987, 4021], 'arrows).': [3990], 'quantitative': [3993], 'comparison': [3994], 'inverse': [4006, 4023, 4038, 5492], 'values': [4012, 4041, 5495, 5524], 'higher': [4014], 'exhibited': [4022, 4152], '0.32': [4027, 5497], '0.27': [4029, 5499], 'G-1,': [4030, 4047, 5500], 'respectively,': [4031, 5501], 'whereas': [4032, 5084, 5138], '12–29': [4036], 'had': [4037], 'ranging': [4042], '0.13': [4044], '0.17': [4046], 'suggesting': [4048, 4297, 4408, 5502, 5614], 'experience': [4054], 'do': [4058], 'center': [4062], 'objective': [4067], 'characterize': [4070], 'Using': [4080], 'undergoes': [4088], 'transition': [4090], 'ordered,': [4101], 'specific,': [4102], 'variations': [4125], 'likely': [4130, 4759], 'distinct': [4132, 5713], '(residues': [4145], '12R1,': [4146], '21R1,': [4147], '27R1,': [4148], '28R1': [4149], '29R1)': [4151], 'least': [4154, 5374, 5526], 'Together': [4158], 'this': [4170, 4172, 5126, 5785], 'lack': [4173, 5140], 'suggests': [4176], 'β-sheet-containing': [4185], 'core': [4186, 4433, 4528, 4784, 5322, 5588], 'agrees': [4193], 'previous': [4195], 'analyses': [4196], 'showing': [4200], '1–7': [4203], '35Westermark': [4235], 'Engstrèom': [4237], 'Betsholtz': [4243], '1990;': [4252], '87:': [4253], '5036-5040Crossref': [4254], '(701)': [4257], '36Nilsson': [4260], 'M.R.': [4261], 'Raleigh': [4262], 'D.P.': [4263], '294:': [4268], '1375-1385Crossref': [4269], '(136)': [4272], 'there': [4286], 'sites,': [4296, 5486], 'molecules.': [4319], 'supported': [4324], 'constrains': [4333], 'contact.': [4344], 'recent': [4347], 'study': [4349], 'tau': [4351, 4356, 4845], 'singly': [4354], 'molecules,': [4357], 'exchange-narrowed': [4358], 'single-line': [4359], 'hyperfine': [4363, 4421, 4506], '(i.e.': [4365], 'peaks)': [4368, 4427], 'Such': [4390, 5223], 'exchange': [4391, 4453, 4475, 4485, 4519], 'narrowing': [4392], 'orbital': [4394], 'overlap': [4395, 5312], 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4}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-16T06:20:06.290424', 'created_date': '2016-06-24'}
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