Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2168569886', 'doi': 'https://doi.org/10.1083/jcb.201110049', 'title': 'The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking', 'display_name': 'The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking', 'publication_year': 2012, 'publication_date': '2012-06-11', 'ids': {'openalex': 'https://openalex.org/W2168569886', 'doi': 'https://doi.org/10.1083/jcb.201110049', 'mag': '2168569886', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22689656', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3373400'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.201110049', 'pdf_url': 'http://jcb.rupress.org/content/jcb/197/6/789.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://jcb.rupress.org/content/jcb/197/6/789.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061316267', 'display_name': 'Karel F. Liem', 'orcid': 'https://orcid.org/0000-0002-1566-5561'}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Karel F. Liem', 'raw_affiliation_strings': ['Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065 1'], 'affiliations': [{'raw_affiliation_string': 'Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065 1', 'institution_ids': ['https://openalex.org/I39965400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012250175', 'display_name': 'Alyson Ashe', 'orcid': 'https://orcid.org/0000-0001-7334-0389'}, 'institutions': [{'id': 'https://openalex.org/I217937681', 'display_name': 'QIMR Berghofer Medical Research Institute', 'ror': 'https://ror.org/004y8wk30', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I217937681']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Alyson Ashe', 'raw_affiliation_strings': ['Epigenetics Laboratory, Queensland Institute of Medical Research, Herston, Queensland 4006, Australia 2'], 'affiliations': [{'raw_affiliation_string': 'Epigenetics Laboratory, Queensland Institute of Medical Research, Herston, Queensland 4006, Australia 2', 'institution_ids': ['https://openalex.org/I217937681']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020189766', 'display_name': 'Mu He', 'orcid': 'https://orcid.org/0000-0002-3812-6165'}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mu He', 'raw_affiliation_strings': ['Biochemistry, Cell, and Molecular Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065 3', 'Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065 1'], 'affiliations': [{'raw_affiliation_string': 'Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065 1', 'institution_ids': ['https://openalex.org/I39965400']}, {'raw_affiliation_string': 'Biochemistry, Cell, and Molecular Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065 3', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006629649', 'display_name': 'Peter Satir', 'orcid': 'https://orcid.org/0000-0003-3665-9387'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter Satir', 'raw_affiliation_strings': ['Albert Einstein College of Medicine, Bronx, NY 10461 4'], 'affiliations': [{'raw_affiliation_string': 'Albert Einstein College of Medicine, Bronx, NY 10461 4', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058482061', 'display_name': 'Jennifer L. Moran', 'orcid': 'https://orcid.org/0000-0002-5664-4716'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Moran', 'raw_affiliation_strings': ['Broad Institute of MIT and Harvard, Cambridge, MA 02142 5'], 'affiliations': [{'raw_affiliation_string': 'Broad Institute of MIT and Harvard, Cambridge, MA 02142 5', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041250587', 'display_name': 'David R. Beier', 'orcid': 'https://orcid.org/0000-0002-0325-8520'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Beier', 'raw_affiliation_strings': ['Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 6'], 'affiliations': [{'raw_affiliation_string': 'Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 6', 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072370884', 'display_name': 'Carol Wicking', 'orcid': 'https://orcid.org/0000-0002-7225-3803'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Carol Wicking', 'raw_affiliation_strings': ['Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia 7'], 'affiliations': [{'raw_affiliation_string': 'Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia 7', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077165179', 'display_name': 'Kathryn V. Anderson', 'orcid': 'https://orcid.org/0000-0003-1657-2161'}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Kathryn V. Anderson', 'raw_affiliation_strings': ['Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065 1'], 'affiliations': [{'raw_affiliation_string': 'Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065 1', 'institution_ids': ['https://openalex.org/I39965400']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5077165179'], 'corresponding_institution_ids': ['https://openalex.org/I39965400'], 'apc_list': None, 'apc_paid': None, 'fwci': 11.542, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 203, 'citation_normalized_percentile': {'value': 0.999953, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '197', 'issue': '6', 'first_page': '789', 'last_page': '800'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11412', 'display_name': 'Ciliopathies: Genetic Disorders Involving Primary Cilia', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11412', 'display_name': 'Ciliopathies: Genetic Disorders Involving Primary Cilia', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Molecular Mechanisms of Kidney Development and Disease', 'score': 0.9682, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ciliogenesis', 'display_name': 'Ciliogenesis', 'score': 0.8172148}, {'id': 'https://openalex.org/keywords/gli2', 'display_name': 'GLI2', 'score': 0.6376599}, {'id': 'https://openalex.org/keywords/gli3', 'display_name': 'GLI3', 'score': 0.58265734}, {'id': 'https://openalex.org/keywords/smoothened', 'display_name': 'Smoothened', 'score': 0.5718682}, {'id': 'https://openalex.org/keywords/intraflagellar-transport', 'display_name': 'Intraflagellar Transport', 'score': 0.548264}, {'id': 'https://openalex.org/keywords/hedgehog-signaling', 'display_name': 'Hedgehog Signaling', 'score': 0.5228}, {'id': 'https://openalex.org/keywords/transport-protein', 'display_name': 'Transport protein', 'score': 0.5111745}], 'concepts': [{'id': 'https://openalex.org/C100094513', 'wikidata': 'https://www.wikidata.org/wiki/Q180436', 'display_name': 'Cilium', 'level': 2, 'score': 0.96663296}, {'id': 'https://openalex.org/C37590093', 'wikidata': 'https://www.wikidata.org/wiki/Q978456', 'display_name': 'Intraflagellar transport', 'level': 4, 'score': 0.90586424}, {'id': 'https://openalex.org/C195267511', 'wikidata': 'https://www.wikidata.org/wiki/Q5119969', 'display_name': 'Ciliogenesis', 'level': 3, 'score': 0.8172148}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7821865}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6781939}, {'id': 'https://openalex.org/C120407494', 'wikidata': 'https://www.wikidata.org/wiki/Q14886491', 'display_name': 'GLI2', 'level': 4, 'score': 0.6376599}, {'id': 'https://openalex.org/C2776637008', 'wikidata': 'https://www.wikidata.org/wiki/Q14860072', 'display_name': 'Sonic hedgehog', 'level': 3, 'score': 0.6226182}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.58365715}, {'id': 'https://openalex.org/C97182474', 'wikidata': 'https://www.wikidata.org/wiki/Q14886904', 'display_name': 'GLI3', 'level': 5, 'score': 0.58265734}, {'id': 'https://openalex.org/C145837895', 'wikidata': 'https://www.wikidata.org/wiki/Q18031607', 'display_name': 'Smoothened', 'level': 4, 'score': 0.5718682}, {'id': 'https://openalex.org/C57581600', 'wikidata': 'https://www.wikidata.org/wiki/Q2449730', 'display_name': 'Transport protein', 'level': 2, 'score': 0.5111745}, {'id': 'https://openalex.org/C144647389', 'wikidata': 'https://www.wikidata.org/wiki/Q423042', 'display_name': 'Membrane protein', 'level': 3, 'score': 0.46181428}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.37360018}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.32184416}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23952043}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16816667}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.118804276}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.092517376}, {'id': 'https://openalex.org/C158448853', 'wikidata': 'https://www.wikidata.org/wiki/Q425218', 'display_name': 'Repressor', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002923', 'descriptor_name': 'Cilia', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': True}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002923', 'descriptor_name': 'Cilia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002923', 'descriptor_name': 'Cilia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003598', 'descriptor_name': 'Cytoskeletal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005407', 'descriptor_name': 'Flagella', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005407', 'descriptor_name': 'Flagella', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016547', 'descriptor_name': 'Kinesin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016547', 'descriptor_name': 'Kinesin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016547', 'descriptor_name': 'Kinesin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051741', 'descriptor_name': 'Kruppel-Like Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051741', 'descriptor_name': 'Kruppel-Like Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051741', 'descriptor_name': 'Kruppel-Like Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008854', 'descriptor_name': 'Microscopy, Electron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000075746', 'descriptor_name': 'Zinc Finger Protein Gli2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.201110049', 'pdf_url': 'http://jcb.rupress.org/content/jcb/197/6/789.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3373400', 'pdf_url': 'https://europepmc.org/articles/pmc3373400?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://nrs.harvard.edu/urn-3:HUL.InstRepos:10610353', 'pdf_url': 'https://dash.harvard.edu/bitstream/1/10610353/1/3373400.pdf', 'source': {'id': 'https://openalex.org/S4306401540', 'display_name': 'Digital Access to Scholarship at Harvard (DASH) (Harvard University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I136199984', 'host_organization_name': 'Harvard University', 'host_organization_lineage': ['https://openalex.org/I136199984'], 'host_organization_lineage_names': ['Harvard University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373400', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22689656', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.201110049', 'pdf_url': 'http://jcb.rupress.org/content/jcb/197/6/789.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W162961686', 'https://openalex.org/W1971688911', 'https://openalex.org/W1975584335', 'https://openalex.org/W1975679481', 'https://openalex.org/W1976708316', 'https://openalex.org/W1983341583', 'https://openalex.org/W1983688519', 'https://openalex.org/W1987913532', 'https://openalex.org/W1993880917', 'https://openalex.org/W1995651171', 'https://openalex.org/W1998796212', 'https://openalex.org/W1999982116', 'https://openalex.org/W2007764395', 'https://openalex.org/W2012022940', 'https://openalex.org/W2019150363', 'https://openalex.org/W2026137500', 'https://openalex.org/W2033483229', 'https://openalex.org/W2041964741', 'https://openalex.org/W2043384567', 'https://openalex.org/W2046798922', 'https://openalex.org/W2048262130', 'https://openalex.org/W2052097916', 'https://openalex.org/W2059790042', 'https://openalex.org/W2062938087', 'https://openalex.org/W2064818329', 'https://openalex.org/W2075495332', 'https://openalex.org/W2080273070', 'https://openalex.org/W2082853783', 'https://openalex.org/W2085132889', 'https://openalex.org/W2085356690', 'https://openalex.org/W2090068859', 'https://openalex.org/W2091684557', 'https://openalex.org/W2093964879', 'https://openalex.org/W2094452381', 'https://openalex.org/W2095243783', 'https://openalex.org/W2098440102', 'https://openalex.org/W2101266961', 'https://openalex.org/W2105663489', 'https://openalex.org/W2106081234', 'https://openalex.org/W2110348183', 'https://openalex.org/W2110426898', 'https://openalex.org/W2113929186', 'https://openalex.org/W2114749367', 'https://openalex.org/W2119806727', 'https://openalex.org/W2122297545', 'https://openalex.org/W2127882408', 'https://openalex.org/W2132749637', 'https://openalex.org/W2136445329', 'https://openalex.org/W2139168265', 'https://openalex.org/W2140864413', 'https://openalex.org/W2141575986', 'https://openalex.org/W2142697077', 'https://openalex.org/W2160084509', 'https://openalex.org/W2167353494', 'https://openalex.org/W2170193319'], 'related_works': ['https://openalex.org/W4249644804', 'https://openalex.org/W4242167910', 'https://openalex.org/W2171103892', 'https://openalex.org/W2105663489', 'https://openalex.org/W2094452381', 'https://openalex.org/W2066480724', 'https://openalex.org/W2043881651', 'https://openalex.org/W2012535690', 'https://openalex.org/W1971060771', 'https://openalex.org/W1969050050'], 'abstract_inverted_index': {'Two': [0], 'intraflagellar': [1], 'transport': [2], '(IFT)': [3], 'complexes,': [4], 'IFT-A': [5, 29, 61, 72, 127, 148], 'and': [6, 9, 13, 38, 66, 80, 103, 137, 158], 'IFT-B,': [7], 'build': [8], 'maintain': [10], 'primary': [11, 109], 'cilia': [12, 36, 85, 110, 156], 'are': [14], 'required': [15], 'for': [16], 'activity': [17, 122, 143], 'of': [18, 27, 41, 49, 55, 114, 133, 141, 147, 152, 155], 'the': [19, 28, 42, 74, 98, 112, 119, 139, 145], 'Sonic': [20], 'hedgehog': [21], '(Shh)': [22], 'pathway.': [23, 44], 'A': [24], 'weak': [25], 'allele': [26], 'gene,': [30], 'Ift144,': [31], 'caused': [32, 51], 'subtle': [33], 'defects': [34], 'in': [35, 59, 111, 124, 144], 'structure': [37, 157], 'ectopic': [39], 'activation': [40], 'Shh': [43, 68, 75, 121, 142], 'In': [45, 70, 96], 'contrast,': [46, 97], 'strong': [47, 71], 'loss': [48, 140], 'IFT-A,': [50], 'by': [52, 94], 'either': [53], 'absence': [54, 113, 146], 'Ift144': [56], 'or': [57], 'mutations': [58], 'two': [60], 'genes,': [62], 'blocked': [63], 'normal': [64], 'ciliogenesis': [65], 'decreased': [67, 134], 'signaling.': [69], 'mutants,': [73], 'pathway': [76, 90], 'proteins': [77, 100], 'Gli2,': [78], 'Sufu,': [79], 'Kif7': [81], 'localized': [82], 'correctly': [83], 'to': [84, 106, 108], 'tips,': [86], 'suggesting': [87], 'that': [88, 118, 138], 'these': [89], 'components': [91], 'were': [92], 'trafficked': [93], 'IFT-B.': [95], 'membrane': [99, 159], 'Arl13b,': [101], 'ACIII,': [102], 'Smo': [104], 'failed': [105], 'localize': [107], 'IFT-A.': [115], 'We': [116], 'propose': [117], 'increased': [120], 'seen': [123], 'partial': [125], 'loss-of-function': [126], 'mutants': [128], 'may': [129], 'be': [130], 'a': [131, 150], 'result': [132, 151], 'ciliary': [135], 'ACIII': [136], 'is': [149], 'severe': [153], 'disruptions': [154], 'protein': [160], 'trafficking.': [161]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2168569886', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-01T04:41:54.294437', 'created_date': '2016-06-24'}