Title: 5-HT1AReceptors Modulate the Consolidation of Learning in Normal and Cognitively Impaired Rats
Abstract: Attempts were made to further analyze the role of 5-HT1Areceptors in consolidation of learning by evaluating the role of these receptors in cognitively normal and impaired animals. The effects of post-training administration of 8-OH-DPAT and 5-HT1Areceptor antagonists, WAY 100135, WAY 100635, and S-UH-301, plus the cholinergic and glutamatergic antagonists, scopolamine and dizolcipine, respectively, were determined using an autoshaping learning task. The results showed that 8-OH-DPAT increased the number of conditioned responses, whereas WAY100135, WAY100635, and S-UH-301, and the 5-HT depleter,p-chloroamphetamine (PCA), had no effect. PCA did not change the silent properties of the 5-HT1Areceptor antagonists. PCA, WAY100635, and S-UH-301, but not GR127935 (a 5-HT1B/1D-receptor antagonist) or MDL100907 (a 5-HT2Areceptor antagonist), reversed the effect to 8-OH-DPAT. Ketanserin (a 5-HT2A/2Creceptor antagonist) and ondansetron (a 5-HT3receptor antagonist), at a dose that increased the conditioned responses by itself, reversed the effect of 8-OH-DPAT. Moreover, 8-OH-DPAT or S-UH-301 reversed the learning deficit induced by scopolamine and dizocilpine whereas WAY100635 reversed the effect of scopolamine only. These data confirm a role for presynaptic 5-HT1Areceptors during the consolidation of learning and support the hypothesis that serotonergic, cholinergic, and glutamatergic systems interact in cognitively impaired animals.
Publication Year: 1999
Publication Date: 1999-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 56
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot