Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2168080476', 'doi': 'https://doi.org/10.1378/chest.130.5.1471', 'title': 'Conversion to Bosentan From Prostacyclin Infusion Therapy in Pulmonary Arterial Hypertension', 'display_name': 'Conversion to Bosentan From Prostacyclin Infusion Therapy in Pulmonary Arterial Hypertension', 'publication_year': 2006, 'publication_date': '2006-11-01', 'ids': {'openalex': 'https://openalex.org/W2168080476', 'doi': 'https://doi.org/10.1378/chest.130.5.1471', 'mag': '2168080476', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17099026'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1378/chest.130.5.1471', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76900504', 'display_name': 'CHEST Journal', 'issn_l': '0012-3692', 'issn': ['0012-3692', '1931-3543'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5104049941', 'display_name': 'Manfred Steiner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'M. Kathryn Steiner', 'raw_affiliation_strings': ['Tufts-New England Medical Center, Boston, MA'], 'affiliations': [{'raw_affiliation_string': 'Tufts-New England Medical Center, Boston, MA', 'institution_ids': ['https://openalex.org/I1290900354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010237095', 'display_name': 'Ioana R. Preston', 'orcid': 'https://orcid.org/0000-0002-1378-7362'}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ioana R. Preston', 'raw_affiliation_strings': ['Tufts-New England Medical Center, Boston, MA'], 'affiliations': [{'raw_affiliation_string': 'Tufts-New England Medical Center, Boston, MA', 'institution_ids': ['https://openalex.org/I1290900354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071223454', 'display_name': 'James R. Klinger', 'orcid': 'https://orcid.org/0000-0003-2997-5955'}, 'institutions': [{'id': 'https://openalex.org/I2800446032', 'display_name': 'Rhode Island Hospital', 'ror': 'https://ror.org/01aw9fv09', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800446032', 'https://openalex.org/I4210151747']}, {'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James R. Klinger', 'raw_affiliation_strings': ['Rhode Island Hospital, Providence, RI'], 'affiliations': [{'raw_affiliation_string': 'Rhode Island Hospital, Providence, RI', 'institution_ids': ['https://openalex.org/I2800446032', 'https://openalex.org/I196272386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009003396', 'display_name': 'Gerard J. Criner', 'orcid': 'https://orcid.org/0000-0003-1267-3483'}, 'institutions': [{'id': 'https://openalex.org/I4210117083', 'display_name': 'Temple University Hospital', 'ror': 'https://ror.org/028rvnd71', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117083']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerard J. Criner', 'raw_affiliation_strings': ['Temple University Hospital, Philadelphia, PA'], 'affiliations': [{'raw_affiliation_string': 'Temple University Hospital, Philadelphia, PA', 'institution_ids': ['https://openalex.org/I4210117083']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021150751', 'display_name': 'Aaron B. Waxman', 'orcid': 'https://orcid.org/0000-0001-7797-0361'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Aaron B. Waxman', 'raw_affiliation_strings': ['Massachusetts General Hospital, Boston, MA'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital, Boston, MA', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032869220', 'display_name': 'Harrison W. Farber', 'orcid': 'https://orcid.org/0000-0002-0297-7902'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Harrison W. Farber', 'raw_affiliation_strings': ['Boston Medical Center, Boston, MA'], 'affiliations': [{'raw_affiliation_string': 'Boston Medical Center, Boston, MA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067984012', 'display_name': 'Nicholas S. Hill', 'orcid': 'https://orcid.org/0000-0002-8242-8339'}, 'institutions': [{'id': 'https://openalex.org/I1290900354', 'display_name': 'Tufts Medical Center', 'ror': 'https://ror.org/002hsbm82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290900354']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicholas S. Hill', 'raw_affiliation_strings': ['Tufts-New England Medical Center, Boston, MA'], 'affiliations': [{'raw_affiliation_string': 'Tufts-New England Medical Center, Boston, MA', 'institution_ids': ['https://openalex.org/I1290900354']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5104049941'], 'corresponding_institution_ids': ['https://openalex.org/I1290900354'], 'apc_list': {'value': 3790, 'currency': 'USD', 'value_usd': 3790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.727, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.900242, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '130', 'issue': '5', 'first_page': '1471', 'last_page': '1480'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10728', 'display_name': 'Pulmonary Hypertension Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10728', 'display_name': 'Pulmonary Hypertension Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10821', 'display_name': 'Cardiovascular Function and Risk Factors', 'score': 0.9685, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11217', 'display_name': 'Cardiac Arrhythmias and Treatments', 'score': 0.9669, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/treprostinil', 'display_name': 'Treprostinil', 'score': 0.9487004}], 'concepts': [{'id': 'https://openalex.org/C2781109936', 'wikidata': 'https://www.wikidata.org/wiki/Q419769', 'display_name': 'Bosentan', 'level': 4, 'score': 0.9601748}, {'id': 'https://openalex.org/C2776432619', 'wikidata': 'https://www.wikidata.org/wiki/Q3495231', 'display_name': 'Treprostinil', 'level': 3, 'score': 0.9487004}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9484701}, {'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.8289845}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.5737316}, {'id': 'https://openalex.org/C2780940725', 'wikidata': 'https://www.wikidata.org/wiki/Q206280', 'display_name': 'Pulmonary artery', 'level': 2, 'score': 0.5284305}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.52475715}, {'id': 'https://openalex.org/C2780930700', 'wikidata': 'https://www.wikidata.org/wiki/Q1128595', 'display_name': 'Pulmonary hypertension', 'level': 2, 'score': 0.505148}, {'id': 'https://openalex.org/C178853913', 'wikidata': 'https://www.wikidata.org/wiki/Q1642137', 'display_name': 'Hemodynamics', 'level': 2, 'score': 0.41559818}, {'id': 'https://openalex.org/C144980905', 'wikidata': 'https://www.wikidata.org/wiki/Q24721308', 'display_name': 'Endothelin receptor', 'level': 3, 'score': 0.13696659}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077300', 'descriptor_name': 'Bosentan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007262', 'descriptor_name': 'Infusions, Intravenous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010807', 'descriptor_name': 'Physical Endurance', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010807', 'descriptor_name': 'Physical Endurance', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D010807', 'descriptor_name': 'Physical Endurance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010865', 'descriptor_name': 'Pilot Projects', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012720', 'descriptor_name': 'Severity of Illness Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D016138', 'descriptor_name': 'Walking', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016138', 'descriptor_name': 'Walking', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1378/chest.130.5.1471', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76900504', 'display_name': 'CHEST Journal', 'issn_l': '0012-3692', 'issn': ['0012-3692', '1931-3543'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17099026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1482130966', 'https://openalex.org/W1987769817', 'https://openalex.org/W1994219663', 'https://openalex.org/W2006822727', 'https://openalex.org/W2007270483', 'https://openalex.org/W2034348825', 'https://openalex.org/W2039172749', 'https://openalex.org/W2048443661', 'https://openalex.org/W2053890291', 'https://openalex.org/W2063193942', 'https://openalex.org/W2102416332', 'https://openalex.org/W2135510321', 'https://openalex.org/W2143183313', 'https://openalex.org/W2160056424', 'https://openalex.org/W2313098007', 'https://openalex.org/W2313158847', 'https://openalex.org/W2321522617', 'https://openalex.org/W2988610037', 'https://openalex.org/W4245666729'], 'related_works': ['https://openalex.org/W4254536261', 'https://openalex.org/W4253406936', 'https://openalex.org/W2914992031', 'https://openalex.org/W2417172109', 'https://openalex.org/W2184784963', 'https://openalex.org/W2143752321', 'https://openalex.org/W2034734056', 'https://openalex.org/W2026656322', 'https://openalex.org/W1997313140', 'https://openalex.org/W1886680035'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2168080476', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-12T03:23:12.875978', 'created_date': '2016-06-24'}