Publication Information

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'https://openalex.org/W2011619507', 'https://openalex.org/W2004854382', 'https://openalex.org/W1979128899', 'https://openalex.org/W1970596941', 'https://openalex.org/W1969175013', 'https://openalex.org/W1922136968', 'https://openalex.org/W128586370'], 'abstract_inverted_index': {'Heptahelical': [0, 316], 'receptor': [1, 19, 49, 229, 317, 335, 365, 545, 798, 848, 1244, 1455, 1507, 1815, 1944, 2690, 2762, 2879, 3348, 3362, 3411, 3679, 4263, 4271, 4359, 4440, 4465, 4479, 4545, 4556], 'coupling': [2, 211, 318, 527, 900, 984, 1241, 1260, 1328, 1465, 1603, 1636, 1723, 1808, 2848, 3345, 3463, 3614, 3663, 3676, 4179, 4310, 4562], 'selectivity': [3, 319, 1261, 1604, 1724, 4563], 'to': [4, 142, 230, 320, 458, 546, 901, 987, 1226, 1229, 1242, 1466, 1495, 1545, 1549, 1595, 1601, 1634, 1717, 1826, 1911, 2298, 2415, 2445, 2849, 2934, 2974, 3088, 3302, 3313, 3318, 3380, 3397, 3413, 3467, 3617, 3661, 3664, 3671, 3677, 3865, 4182, 4223, 4311, 4317, 4539], 'G-proteins': [5, 321, 694, 722, 1131, 1556, 1912, 3316, 3339], 'is': [6, 76, 129, 257, 322, 392, 445, 573, 969, 1132, 1137, 1324, 1845, 1888, 3464, 3554, 3595, 3609, 3659, 3800, 3848, 3857, 4274, 4456], 'controlled': [7, 323], 'by': [8, 92, 237, 300, 324, 408, 553, 616, 1139, 1331, 1847, 1989, 2742, 2842, 3113, 3328, 3357, 3481, 3525, 3654, 3725, 4277, 4288, 4402, 4458], 'a': [9, 89, 144, 297, 325, 405, 460, 613, 791, 1142, 1163, 1247, 1719, 1817, 1914, 2084, 2299, 2487, 2587, 2695, 3124, 3285, 3468, 3655, 3712, 3797, 3894, 3905, 3926, 4199, 4255], 'large': [10, 326, 4319], 'contact': [11, 68, 121, 327, 384, 437, 745, 784], 'area': [12, 328], 'that': [13, 79, 107, 168, 206, 234, 249, 284, 329, 395, 423, 484, 522, 550, 565, 600, 1145, 1553, 1586, 1844, 1856, 1873, 1904, 3561, 3890, 3943, 4308, 4557], 'involves': [14, 330], 'several': [15, 331, 1457, 1789], 'portions': [16, 332, 707, 1459, 2917, 2957, 3779], 'of': [17, 23, 72, 83, 135, 151, 173, 188, 192, 198, 201, 213, 226, 253, 263, 267, 288, 333, 339, 388, 399, 451, 467, 489, 504, 508, 514, 517, 529, 542, 569, 579, 583, 604, 693, 700, 703, 708, 721, 729, 743, 846, 892, 1130, 1255, 1505, 1541, 1628, 1791, 1813, 1820, 1839, 1851, 1866, 1878, 2001, 2048, 2087, 2093, 2185, 2195, 2274, 2280, 2302, 2327, 2399, 2439, 2454, 2476, 2519, 2583, 2659, 2671, 2697, 2733, 2749, 2780, 2789, 2797, 2801, 2810, 2814, 2837, 2853, 2888, 2908, 2918, 2949, 2958, 2997, 3003, 3006, 3064, 3293, 3330, 3473, 3475, 3615, 3766, 3770, 3776, 3780, 3869, 3877, 3881, 3896, 3907, 3946, 4152, 4158, 4162, 4169, 4173, 4180, 4268, 4302, 4331, 4373, 4414, 4427, 4508, 4521], 'the': [18, 24, 27, 31, 35, 39, 48, 52, 64, 73, 80, 84, 93, 99, 116, 120, 127, 136, 148, 156, 171, 186, 189, 195, 202, 210, 223, 227, 250, 254, 260, 264, 268, 272, 282, 285, 289, 301, 334, 340, 343, 347, 351, 355, 364, 368, 380, 389, 396, 400, 409, 415, 432, 436, 443, 452, 464, 472, 487, 502, 505, 511, 518, 526, 539, 543, 566, 570, 576, 580, 584, 588, 598, 601, 605, 617, 691, 704, 709, 719, 744, 769, 778, 781, 785, 847, 890, 893, 898, 970, 1127, 1133, 1147, 1152, 1155, 1158, 1230, 1237, 1243, 1250, 1256, 1263, 1290, 1293, 1300, 1327, 1454, 1463, 1480, 1488, 1498, 1502, 1506, 1538, 1546, 1596, 1622, 1711, 1793, 1814, 1821, 1836, 1840, 1848, 1863, 1876, 1902, 2002, 2005, 2193, 2321, 2332, 2335, 2348, 2372, 2397, 2403, 2407, 2416, 2431, 2447, 2455, 2474, 2484, 2495, 2499, 2511, 2520, 2526, 2560, 2581, 2584, 2595, 2657, 2660, 2665, 2672, 2677, 2686, 2698, 2734, 2743, 2765, 2777, 2786, 2794, 2798, 2807, 2811, 2822, 2829, 2838, 2877, 2886, 2891, 2897, 2901, 2919, 2935, 2950, 2959, 2975, 3080, 3083, 3263, 3288, 3322, 3343, 3347, 3350, 3406, 3471, 3558, 3601, 3612, 3667, 3767, 3777, 3794, 3811, 3845, 3854, 3858, 3867, 3870, 3874, 3878, 3882, 3901, 3932, 3937, 3944, 4144, 4148, 4156, 4159, 4166, 4170, 4174, 4178, 4203, 4265, 4269, 4278, 4289, 4299, 4306, 4325, 4332, 4389, 4395, 4398, 4403, 4407, 4425, 4428, 4438, 4482, 4493, 4519, 4522, 4559], 'and': [20, 38, 41, 54, 57, 95, 126, 158, 160, 181, 215, 220, 242, 303, 336, 354, 357, 370, 373, 411, 442, 474, 476, 497, 531, 536, 558, 619, 723, 740, 773, 780, 840, 979, 1289, 1295, 1303, 1477, 1482, 1501, 1591, 1598, 1797, 1860, 1900, 1930, 1946, 2010, 2046, 2072, 2075, 2105, 2108, 2113, 2121, 2160, 2162, 2227, 2269, 2282, 2312, 2334, 2347, 2389, 2449, 2457, 2463, 2562, 2574, 2668, 2688, 2728, 2754, 2760, 2782, 2817, 2819, 2824, 2851, 2855, 2858, 2880, 2903, 2925, 2930, 2937, 2965, 2970, 2977, 3052, 3110, 3123, 3137, 3141, 3193, 3220, 3279, 3295, 3297, 3305, 3349, 3367, 3369, 3375, 3394, 3400, 3600, 3607, 3773, 3786, 3791, 3805, 3809, 3853, 3884, 3914, 4184, 4252, 4283, 4421, 4488, 4492, 4515, 4551], 'each': [21, 337], 'subunit': [22, 86, 138, 292, 338, 402, 454, 608, 789, 1258, 1796, 1824, 1843, 2097], 'G-protein.': [25, 74, 341, 390, 711], 'In': [26, 342, 1154, 2580, 3843], 'G-protein': [28, 128, 231, 290, 344, 444, 547, 606, 770, 1148, 1794, 1822, 1841, 1870, 2881, 3352, 3718, 4175, 4561], 'α': [29, 85, 137, 166, 203, 232, 269, 291, 345, 401, 453, 482, 519, 548, 585, 607, 1257, 1795, 1823, 1842, 1871, 2882, 3719, 4176], 'subunit,': [30, 270, 346, 586, 4177], 'C-terminal': [32, 65, 175, 265, 286, 348, 381, 491, 581, 602, 1238, 1503, 3323, 3855, 3879, 4171], '5': [33, 349, 2309, 3324], 'residues,': [34, 350], 'N': [36, 352, 1265, 2485], 'terminus,': [37, 353, 1882, 2486], 'αN-β1': [40, 356], 'α4–α5': [42, 358], 'loops': [43, 60, 305, 359, 376, 621, 1600, 3789], 'play': [44, 143, 360, 459, 1246, 1718], 'important': [45, 361], 'roles.': [46, 362], 'On': [47, 363, 1453, 4240], 'side,': [50, 366, 1456], 'both': [51, 367, 777, 1479, 1792, 2572, 3398, 4225], 'second': [53, 369, 656], 'third': [55, 371, 658], '(i2': [56, 372], 'i3)': [58, 374], 'intracellular': [59, 375, 659, 1458, 3778, 3788], 'as': [61, 63, 179, 310, 377, 379, 495, 626, 1485, 1487, 1497, 1804, 2391, 2396, 2602, 2702, 2894, 3145, 3403, 3405, 3479, 3522, 3524, 4206, 4304, 4377, 4385, 4424, 4518], 'well': [62, 378, 1486, 3404, 3523], 'tail': [66, 382, 1504, 3856, 3880, 4172], 'probably': [67, 383, 776, 1330], 'these': [69, 124, 385, 440, 748, 1629, 1907, 2599, 3337, 3476, 3716, 3781, 4194, 4241], 'different': [70, 386, 797, 843, 3801, 3819], 'regions': [71, 387, 888, 1254, 1630, 1790], 'It': [75, 391], 'now': [77, 393], 'accepted': [78, 394], 'C': [81, 133, 239, 397, 449, 555, 972, 1547, 1881, 4150], 'terminus': [82, 134, 398, 450, 973, 1266, 1548], 'binds': [87, 403], 'in': [88, 147, 194, 296, 306, 404, 463, 510, 612, 622, 717, 794, 897, 1126, 1236, 1249, 1326, 1462, 1473, 1722, 1807, 1913, 2059, 2083, 2125, 2152, 2164, 2198, 2232, 2371, 2406, 2517, 2525, 2682, 2739, 2827, 2872, 2890, 2900, 2914, 2953, 3079, 3152, 3159, 3200, 3216, 3225, 3256, 3262, 3320, 3385, 3470, 3484, 3555, 3570, 3598, 3605, 3657, 3673, 3810, 3873, 3899, 3954, 4165, 4191, 4322, 4338, 4354, 4378, 4386, 4397, 4406, 4419], 'cavity': [90, 298, 406, 614], 'formed': [91, 299, 407, 615], 'i2': [94, 190, 224, 255, 302, 410, 506, 540, 571, 618, 652, 1481, 1597, 1712, 1849, 1858, 2678, 2735, 2860, 2920, 2960, 3846, 3871, 3902, 4145, 4160, 4300], 'i3': [96, 304, 412, 620, 654, 1483, 1599, 3812], 'loops.': [97, 413], 'Among': [98, 414], 'various': [100, 416, 3717, 4471], 'G-protein-coupled': [101, 417, 639], 'receptors': [102, 106, 112, 125, 162, 219, 418, 422, 428, 441, 478, 535, 730, 989, 1338, 1543, 1593, 1800, 1899, 1905, 2459, 2465, 2564, 2577, 2826, 2857, 3008, 3144, 3378, 3391, 3565, 3761, 3782, 3898, 3919, 4133, 4164, 4195, 4345, 4452], '(GPCRs),': [103, 419], 'class': [104, 152, 307, 313, 420, 468, 623, 629, 1336, 1450, 1474, 1623, 1798, 1896], 'III': [105, 153, 308, 421, 469, 624, 1451, 1624, 1799, 3371, 3390, 3807, 4291, 4495], 'include': [108, 424, 1478, 3925], 'metabotropic': [109, 425, 647], 'glutamate': [110, 426, 1919, 4245], '(mGlu)': [111, 427], 'greatly': [113, 429], 'differ': [114, 169, 236, 430, 485, 552, 1874], 'from': [115, 431, 1149, 1906, 1922, 1938, 2203, 3016, 4511], 'rhodopsin-like': [117, 433, 1898], 'GPCRs,': [118, 309, 434, 625, 1625], 'but': [119, 435, 4229, 4286], 'zone': [122, 438, 2800, 2813], 'between': [123, 165, 439, 481, 747, 796, 842, 1292, 1555, 1589, 1869, 2758, 2923, 2963, 3346, 3802, 3912], 'less': [130, 446, 3859], 'understood.': [131, 447], 'The': [132, 448, 787, 965, 1829, 1940, 1983, 1999, 2305, 2409, 2505, 2507, 2674, 2722, 2730, 2769, 2834, 2916, 2956, 3163, 3258, 3268, 4218, 4476], 'has': [139, 455, 714, 735, 790, 1714, 1892, 3909], 'been': [140, 456, 715, 1470, 1632, 1715, 1802, 1893, 3311, 3910], 'shown': [141, 457, 1633, 3312, 3480, 4190, 4353], 'pivotal': [145, 461, 1720], 'role': [146, 187, 462, 503, 793, 1248, 1721, 3868, 4157], 'selective': [149, 196, 261, 465, 512, 577, 899, 1464, 3613, 4167, 4460, 4485], 'recognition': [150, 197, 262, 466, 513, 578, 3876, 4168], 'GPCRs.': [154, 315, 470, 631, 1452], 'Indeed,': [155, 471, 3650], 'mGlu2': [157, 214, 473, 530, 2112, 2576, 2687, 2759, 2815, 2823, 2854, 2924, 2936, 2964, 2976, 3306, 3402, 3618, 3913, 4270, 4358, 4459], 'mGlu4': [159, 216, 475, 532, 2561, 2585, 2689, 3727, 3916, 4303, 4342, 4381, 4565], '-8': [161, 218, 477, 534], 'can': [163, 479, 3353, 3721], 'discriminate': [164, 480], 'subunits': [167, 233, 483, 549, 1872, 1945, 2006, 2724, 2771, 3478, 3720], 'at': [170, 486, 976, 1834, 1875, 1884, 2317, 2469, 2483, 2909, 3076, 3098, 3178, 3185, 3931, 3950, 4198, 4202, 4500], 'level': [172, 488, 1877, 3005, 3472, 4201], 'their': [174, 238, 243, 490, 554, 559, 1879, 1947, 2106, 2470, 2859, 4136, 4140], 'end': [176, 266, 287, 492, 582, 603], 'only': [177, 235, 493, 551, 1710, 2747, 3415, 3814], '(such': [178, 494], 'Gqo': [180, 496, 2850, 3294, 3399, 3414, 4183, 4350, 4455, 4467], 'Gqz).': [182, 498], 'Here,': [183, 499], 'we': [184, 208, 500, 524, 3892, 4314, 4547], 'examine': [185, 501, 3866, 4155], 'loop': [191, 225, 256, 507, 541, 572, 1302, 1713, 1850, 2679, 2736, 2839, 2921, 2961, 3847, 3872, 3903, 4161, 4301], 'mGluRs': [193, 509], 'this': [199, 515, 1193, 1857, 2558, 2954, 3553, 3652, 3678, 4555], 'region': [200, 516, 968, 1291, 1323, 1552, 1838, 2732], 'subunit.': [204, 520], 'To': [205, 521, 3889], 'aim,': [207, 523, 3891], 'analyzed': [209, 525], 'properties': [212, 528, 2670, 4267], 'or': [217, 533, 653, 657, 1191, 1449, 2480, 2528, 2633, 2746, 3334, 3759, 3904, 3917, 3928, 4059, 4343, 4349, 4364], 'chimeras': [221, 537, 1588, 1948], 'containing': [222, 538, 2235, 2277], 'converse': [228, 544, 3668, 4326], 'termini': [240, 556], '(Gqo,Gqz,': [241, 557], 'point': [244, 560], 'mutants).': [245, 561], 'Our': [246, 562, 1853], 'data': [247, 278, 563, 594, 1854, 2951, 4297], 'demonstrate': [248, 564], 'central': [251, 567, 1864, 2731, 2799, 2812], 'portion': [252, 568, 2796, 2809, 3906], 'responsible': [258, 574, 3610], 'for': [259, 312, 575, 628, 983, 1895, 1934, 2102, 2111, 2192, 2229, 2286, 2314, 2341, 2386, 2605, 2821, 3095, 3265, 3611], 'especially': [271, 587, 1883], 'residue': [273, 589, 1159, 1166, 1195, 3799, 3887], 'on': [274, 590, 690, 2339, 2352, 3131, 3156, 3169, 4213, 4474], 'position': [275, 591, 1885, 3953], '–4.': [276, 592, 1886, 3888], 'These': [277, 593, 1468, 3922, 4296], 'are': [279, 595, 895, 981, 1262, 1460, 2394, 2904, 2927, 2967, 3326, 3817, 4410, 4422, 4504, 4516], 'consistent': [280, 596, 1889], 'with': [281, 294, 597, 610, 706, 1151, 1334, 1890, 2067, 2090, 2155, 2176, 2250, 2271, 2292, 2324, 2379, 2567, 2776, 2785, 2793, 2806, 2896, 3049, 3055, 3066, 3104, 3139, 3174, 3188, 3214, 3222, 3228, 3236, 3243, 3277, 3557, 4329, 4346, 4360, 4370, 4380, 4388, 4435, 4441, 4454, 4466, 4470, 4554, 4564], 'proposal': [283, 599], 'interacts': [293, 609], 'residues': [295, 611, 975, 3325], 'reported': [311, 627, 2603, 2952, 3942], 'I': [314, 630, 1337, 1475, 1897], 'G-protein-coupled-receptors': [632], '(GPCRs)': [633], '1The': [634], 'abbreviations': [635], 'used': [636, 1933, 2191, 2390, 4499], 'are:': [637], 'GPCR,': [638], 'receptor;': [640], 'GABAB,': [641], 'γ-aminobutyric': [642], 'acid,': [643], 'type': [644], 'B;': [645], 'mGlu,': [646], 'glutamate;': [648], 'mGluR,': [649], 'mGlu': [650, 1943, 2441, 3143, 3377, 3564, 4163, 4478], 'receptors;': [651], 'loop,': [655, 1859, 3796, 3813], 'loop;': [660], 'HEK': [661, 2873], '293': [662, 2055, 2874], 'cells,': [663], 'human': [664], 'embryonic': [665], 'kidney': [666], 'cells;': [667], 'IP,': [668], 'inositol': [669], 'phosphates;': [670], 'ELISA,': [671], 'enzyme-linked': [672], 'immunosorbent': [673], 'assay;': [674], 'HA,': [675], 'hemagglutinin;': [676], 'DMEM,': [677], "Dulbecco's": [678, 2060], 'modified': [679, 2061], "Eagle's": [680, 2062], 'medium;': [681], 'PBS,': [682, 3105], 'phosphate-buffered': [683], 'saline.': [684], 'modulate': [685], 'specific': [686, 739, 1818, 1837, 3875], 'signaling': [687], 'pathways': [688], 'depending': [689], 'subset': [692], 'activated.': [695], 'This': [696, 733, 1321, 1887, 3461, 4261], 'requires': [697], 'positive': [698, 3713], 'interaction': [699], 'certain': [701], 'parts': [702], 'GPCR': [705], 'heterotrimeric': [710], 'Recent': [712], 'progress': [713, 734], 'made': [716], 'defining': [718], 'structure': [720, 1239, 4307], 'functional': [724, 844, 2666, 4137], 'studies': [725, 1536, 3486], 'using': [726, 1537, 2430, 2498, 2694, 2764, 3011, 3115, 3284, 3487, 4208, 4543], 'site-directed': [727], 'mutagenesis': [728], 'and/or': [731], 'G-proteins.': [732, 1467], 'provided': [736, 1988], 'increasingly': [737], 'more': [738, 1861, 3849, 3885], 'precise': [741], 'descriptions': [742], 'sites': [746], 'proteins': [749, 986, 1985, 3384], '(1Hamm': [750, 903, 990], 'H.E.': [751, 904, 991, 1309, 1369, 1395, 1415], 'J.': [752, 805, 829, 831, 873, 905, 992, 1051, 1055, 1056, 1073, 1077, 1084, 1087, 1175, 1272, 1273, 1370, 1398, 1436, 1440, 1523, 1609, 1639, 1647, 1650, 1670, 1694, 1726, 1734, 1737, 1760, 1762, 1777, 1953, 1957, 1964, 1967, 2016, 2026, 2029, 2545, 2621, 2636, 2645, 2648, 2711, 2713, 3417, 3427, 3444, 3492, 3496, 3503, 3506, 3528, 3534, 3536, 3620, 3624, 3631, 3634, 3681, 3685, 3692, 3695, 3729, 3733, 3740, 3743, 3823, 3833, 3969, 3993, 4011, 4020, 4023, 4032, 4038, 4043, 4066, 4086, 4094, 4099, 4112, 4114, 4124, 4573], 'Biol.': [753, 819, 906, 993, 1057, 1088, 1176, 1274, 1371, 1399, 1513, 1610, 1651, 1671, 1695, 1738, 1968, 2030, 3507, 3635, 3696, 3744, 3994, 4044], 'Chem.': [754, 907, 994, 1058, 1089, 1177, 1275, 1372, 1400, 1611, 1652, 1672, 1696, 1739, 1969, 2031, 3508, 3636, 3697, 3745, 3995, 4045], '1998;': [755, 908, 995, 1090, 1116, 1276, 1526, 1673, 1970, 3451, 3509, 3637, 3698, 3746, 4580], '273:': [756, 909, 996, 1091, 1277, 1674, 1971, 3510, 3638, 3699, 3747], '669-672Abstract': [757, 910, 997], 'Full': [758, 760, 911, 913, 998, 1000, 1062, 1064, 1093, 1095, 1181, 1183, 1279, 1281, 1376, 1378, 1404, 1406, 1615, 1656, 1658, 1676, 1678, 1700, 1702, 1743, 1745, 1973, 1975, 2035, 2037, 3030, 3032, 3512, 3514, 3640, 3642, 3701, 3703, 3749, 3751, 3999, 4001, 4049, 4051], 'Text': [759, 761, 912, 914, 999, 1001, 1063, 1065, 1094, 1096, 1182, 1184, 1280, 1282, 1377, 1379, 1405, 1407, 1616, 1657, 1659, 1677, 1679, 1701, 1703, 1744, 1746, 1974, 1976, 2036, 2038, 3031, 3033, 3513, 3515, 3641, 3643, 3702, 3704, 3750, 3752, 4000, 4002, 4050, 4052], 'PDF': [762, 915, 1002, 1066, 1097, 1185, 1283, 1380, 1408, 1617, 1660, 1680, 1704, 1747, 1977, 2039, 3034, 3516, 3644, 3705, 3753, 4003, 4053], 'PubMed': [763, 809, 823, 835, 859, 882, 916, 937, 960, 1003, 1022, 1067, 1098, 1119, 1186, 1221, 1284, 1316, 1361, 1381, 1409, 1430, 1444, 1517, 1529, 1579, 1618, 1661, 1681, 1705, 1748, 1766, 1783, 1978, 2040, 2215, 2363, 2552, 2628, 2653, 2717, 3035, 3454, 3517, 3547, 3587, 3645, 3706, 3754, 3976, 4004, 4028, 4054, 4104, 4128], 'Scopus': [764, 810, 824, 836, 860, 883, 917, 938, 961, 1004, 1023, 1068, 1099, 1120, 1187, 1222, 1285, 1317, 1362, 1382, 1410, 1431, 1445, 1518, 1530, 1580, 1662, 1682, 1706, 1749, 1767, 1784, 1979, 2041, 2216, 2364, 2553, 2629, 2718, 3036, 3455, 3518, 3548, 3588, 3646, 3707, 3755, 3977, 4005, 4055, 4129], '(939)': [765, 918, 1005], 'Google': [766, 812, 826, 838, 862, 885, 919, 940, 963, 1006, 1025, 1046, 1070, 1101, 1122, 1189, 1224, 1287, 1319, 1364, 1384, 1412, 1433, 1447, 1520, 1532, 1582, 1619, 1664, 1684, 1708, 1751, 1769, 1786, 1981, 2043, 2218, 2366, 2555, 2631, 2654, 2720, 3038, 3435, 3457, 3520, 3550, 3590, 3648, 3709, 3757, 3841, 3979, 4007, 4029, 4057, 4105, 4131], 'Scholar).': [767, 886, 964, 1123, 1320, 1533, 1583, 1620, 1787, 1982, 2044, 2219, 2367, 2556, 2721, 3551, 3591, 3649, 3710, 3842], 'From': [768], 'α,': [771], 'β,': [772], 'γ': [774], 'subunits,': [775], 'Gα': [779, 788, 985, 3477, 4153], 'βγ': [782], 'dimer': [783], 'receptors.': [786, 1233, 2673], 'decisive': [792, 982], 'discriminating': [795], 'subtypes': [799], '(2Savarese': [800], 'T.M.': [801], 'Fraser': [802], 'C.M.': [803], 'Biochem.': [804, 1778], '1992;': [806], '283:': [807], '1-19Crossref': [808], '(441)': [811], 'Scholar,': [813, 827, 863, 920, 941, 1007, 1026, 1047, 1071, 1102, 1365, 1385, 1413, 1434, 1521, 1665, 1685, 1752, 1770, 3436, 3980, 4030, 4106], '3Bourne': [814], 'H.R.': [815, 924, 1017, 1509], 'Curr.': [816, 1510], 'Opin.': [817, 1511], 'Cell': [818, 1512, 2998], '1997;': [820, 832, 856, 957, 1059, 1218, 1358, 1401, 1514], '9:': [821, 1515], '134-142Crossref': [822, 1516], '(527)': [825, 1519], '4Wess': [828], 'FASEB': [830], '11:': [833], '346-354Crossref': [834], '(511)': [837], 'Scholar)': [839, 1225, 1288, 1448, 2632, 2655, 3458, 3521, 3758, 4132], 'also': [841, 2591, 3924], 'states': [845], '(5Daaka': [849], 'Y.': [850, 1036, 1560, 1776, 3446, 4575], 'Luttrell': [851], 'L.M.': [852], 'Lefkowitz': [853], 'R.J.': [854], 'Nature.': [855, 878, 1018, 1312, 1575, 2211, 2359], '390:': [857], '88-91Crossref': [858], '(1072)': [861], '6Spengler': [864], 'D.': [865, 1015, 1417, 1693, 2022, 2539, 2615, 3963, 4072, 4074], 'Waeber': [866], 'C.': [867, 869, 953, 1053, 1080, 1354, 1641, 1728, 1756, 1960, 2537, 2613, 2707, 3440, 3499, 3627, 3688, 3736, 3961, 4080, 4569], 'Pantaloni': [868], 'Holsboer': [870], 'F.': [871, 1108, 1270, 1566, 2533, 2609, 3957, 3986], 'Bockaert': [872, 1083, 1646, 1733, 1759, 1963, 2025, 2544, 2620, 2644, 2710, 3426, 3443, 3502, 3630, 3691, 3739, 3832, 3968, 4019, 4037, 4572], 'Seeburg': [874], 'P.H.': [875], 'Journot': [876], 'L.': [877, 2547, 2623, 2638, 2647, 3971, 3982, 4013, 4022, 4042, 4084, 4120], '1993;': [879, 1019, 1313, 1576], '365:': [880, 1577], '170-175Crossref': [881], '(1122)': [884], 'Several': [887], 'along': [889], 'sequence': [891, 2509, 2524, 2589, 2675, 2779, 2788], 'Gα-proteins': [894], 'involved': [896, 1325, 1461, 1806], 'GPCRs': [902, 1476, 3309], '7Lichtarge': [921], 'O.': [922, 951, 1352], 'Bourne': [923, 954, 1016, 1039, 1355], 'Cohen': [925], 'F.E.': [926], 'Proc.': [927, 3537], 'Natl.': [928, 3538], 'Acad.': [929, 3539], 'Sci.': [930, 3540], 'U.': [931, 3541], 'S.': [932, 1032, 1075, 1112, 1168, 1204, 1212, 1570, 1574, 1691, 1955, 2535, 2611, 3419, 3425, 3442, 3494, 3542, 3622, 3683, 3731, 3825, 3831, 3959, 4571], 'A.': [933, 1106, 1419, 1564, 1568, 1572, 1667, 1774, 3543, 3992, 4062], '1996;': [934, 1043, 1373, 1653, 1740, 3432, 3838], '93:': [935], '7507-7511Crossref': [936], '(169)': [939], '8Onrust': [942], 'R.': [943, 1344, 1643, 1730, 2643, 4018, 4092], 'Herzmark': [944, 1029, 1345], 'P.': [945, 947, 1030, 1346, 1348], 'Chi': [946, 1347], 'Garcia': [948, 1349], 'P.D.': [949, 1350], 'Lichtarge': [950, 1351], 'Kingsley': [952, 1353], 'H.': [955, 1040, 1200, 1210, 1356, 1387], 'Science.': [956, 1217, 1357, 1426], '275:': [958, 1359, 1698], '381-384Crossref': [959, 1360], '(196)': [962, 1363], 'best': [966], 'characterized': [967], 'extreme': [971, 1264, 1880], 'where': [974], 'positions': [977, 3816], '–3': [978], '–4': [980, 1125, 1160, 3299], 'some': [988], '9Conklin': [1008], 'B.R.': [1009, 1028, 3530], 'Farfel': [1010, 1037], 'Z.': [1011, 1038], 'Lustig': [1012], 'K.D.': [1013], 'Julius': [1014], '363:': [1020], '274-276Crossref': [1021], '(609)': [1024], '10Conklin': [1027], 'Ishida': [1031], 'Voyno-Yasenetskaya': [1033], 'T.A.': [1034], 'Sun': [1035], 'Mol.': [1041, 3430, 3449, 3582, 3836, 4578], 'Pharmacol.': [1042, 1524, 3431, 3450, 3583, 3837, 4579], '50:': [1044, 3433, 3839], '885-890PubMed': [1045], '11Kostenis': [1048], 'E.': [1049, 1268], 'Gomeza': [1050], 'Lerche': [1052], 'Wess': [1054, 1271, 3535], '272:': [1060, 1402], '23675-23681Abstract': [1061], '(69)': [1069], '12Blahos': [1072], 'Mary': [1074, 1954, 3418, 3493, 3621, 3682, 3730, 3824], 'Perroy': [1076, 1956, 3495, 3623, 3684, 3732], 'De': [1078, 1958, 2639, 3497, 3625, 3686, 3734, 4014], 'Colle': [1079, 1959, 3498, 3626, 3687, 3735], 'Brabet': [1081, 1961, 2019, 3420, 3500, 3628, 3689, 3737, 3826], 'I.': [1082, 1962, 2020, 3421, 3501, 3629, 3690, 3738, 3827, 4078], 'Pin': [1085, 1437, 1648, 1735, 1965, 2027, 2542, 2618, 3428, 3447, 3504, 3632, 3693, 3741, 3834, 3966, 3987, 4039, 4087, 4121, 4576], 'J.-P.': [1086, 1438, 1649, 1736, 1754, 1966, 2028, 2543, 2619, 2705, 3429, 3448, 3505, 3633, 3694, 3742, 3835, 3967, 3988, 4040, 4088, 4122, 4577], '25765-25769Abstract': [1092, 1972, 3511, 3639, 3700, 3748], '(58)': [1100, 1286, 1980, 3519, 3647, 3708, 3756], '13Bahia': [1103], 'D.S.': [1104], 'Wise': [1105], 'Fanelli': [1107], 'Lee': [1109], 'M.': [1110, 1208, 1562, 2641, 4016], 'Rees': [1111], 'Milligan': [1113, 1173], 'G.': [1114, 1174, 2024, 4064, 4116], 'Biochemistry.': [1115], '37:': [1117], '11555-11562Crossref': [1118], '(81)': [1121], 'Residue': [1124, 3592], 'Gi': [1128], 'family': [1129], 'cysteine': [1134], 'residue,': [1135], 'which': [1136, 1298, 1811, 2828, 3321, 3594, 3900, 4232], 'ADP-ribosylated': [1138], 'pertussis': [1140, 3381, 3602], 'toxin,': [1141], 'covalent': [1143], 'modification': [1144, 2696], 'prevents': [1146], 'interacting': [1150, 1332], 'receptor.': [1153, 4382, 4392], 'Gq': [1156], 'family,': [1157], 'must': [1161], 'be': [1162, 1197, 1550, 1827, 2443, 3355, 3722], 'bulky': [1164], 'aromatic': [1165], '(14Liu': [1167], 'Carrillo': [1169], 'J.J.': [1170], 'Pediani': [1171], 'J.D.': [1172], '2002;': [1178], '277:': [1179], '25707-25714Abstract': [1180], '(35)': [1188], 'Scholar),': [1190, 1709, 4008, 4058], 'alternatively,': [1192], 'Tyr': [1194], 'may': [1196, 1245], 'phosphorylated': [1198], '(15Umemori': [1199], 'Inoue': [1201], 'T.': [1202, 1216, 1558, 1645, 1732, 1772, 2018, 4068, 4082, 4108], 'Kume': [1203], 'Sekiyama': [1205], 'N.': [1206, 3019, 3532], 'Nagao': [1207], 'Itoh': [1209], 'Nakanishi': [1211], 'Mikoshiba': [1213], 'K.': [1214, 1389, 4096], 'Yamamoto': [1215], '276:': [1219, 2033, 4047], '1878-1881Crossref': [1220], '(128)': [1223], 'efficiently': [1227, 3723, 4237], 'couple': [1228, 1910, 3379, 3396, 3412], 'phospholipase': [1231, 3341], 'C-activating': [1232], 'Conformational': [1234], 'changes': [1235], 'upon': [1240], 'activation': [1251, 1342], 'process.': [1252], 'Other': [1253], 'determining': [1259], '(16Kostenis': [1267], 'Zeng': [1269], '17886-17892Abstract': [1278], 'α4': [1294], 'α5': [1296], 'helices,': [1297], 'includes': [1299], 'L9': [1301], 'β6': [1304], 'sheet': [1305], '(17Noel': [1306], 'J.P.': [1307], 'Hamm': [1308, 1368, 1394], 'Sigler': [1310], 'P.B.': [1311], '366:': [1314], '654-663Crossref': [1315], '(708)': [1318], 'latter': [1322], 'selectivity,': [1329], 'directly': [1333], 'either': [1335, 2477, 2606, 3331, 3726, 3915, 4347], '(rhodopsin-like': [1339], 'family)': [1340], 'during': [1341], '(8Onrust': [1343], '18Mazzoni': [1366], 'M.R.': [1367], '271:': [1374, 1654, 1741], '30034-30040Abstract': [1375], '(47)': [1383], '19Bae': [1386], 'Anderson': [1388], 'Flood': [1390], 'L.A.': [1391], 'Skiba': [1392], 'N.P.': [1393], 'Graber': [1396], 'S.G.': [1397], '32071-32077Abstract': [1403], '(59)': [1411], '20Hamm': [1414], 'Deretic': [1416], 'Arendt': [1418], 'Hargrave': [1420], 'P.A.': [1421], 'Koenig': [1422], 'B.': [1423, 3021, 4070, 4098, 4110, 4118], 'Hofmann': [1424], 'K.P.': [1425], '1988;': [1427], '241:': [1428], '832-835Crossref': [1429], '(395)': [1432], '21Bockaert': [1435], 'EMBO': [1439, 1761, 2712, 4123], '1999;': [1441, 2549, 2625, 3027, 3973], '18:': [1442], '1723-1729Crossref': [1443], '(1230)': [1446], 'have': [1469, 1631, 1801, 3310], 'extensively': [1471], 'studied': [1472], 'loops,': [1484], 'amphipathic': [1489], 'helix,': [1490], 'called': [1491, 2726, 2773], 'H8': [1492], '(and': [1493], 'referred': [1494], 'previously': [1496, 1951, 2014, 2175, 2204, 2531, 2604, 3941], 'i4': [1499], 'loop)': [1500], '(3Bourne': [1508], '22Wess': [1522], 'Ther.': [1525], '80:': [1527], '231-264Crossref': [1528], '(370)': [1531], 'For': [1534, 2473, 2598], 'example,': [1535], 'splice': [1539], 'variants': [1540], 'prostanoid': [1542], 'pointed': [1544, 1594], 'one': [1551, 4512], 'discriminates': [1554, 1868], '(23Namba': [1557], 'Sugimoto': [1559], 'Negishi': [1561], 'Irie': [1563], 'Ushikubi': [1565], 'Kakizuka': [1567], 'Ito': [1569], 'Ichikawa': [1571], 'Narumiya': [1573], '166-170Crossref': [1578], '(518)': [1581], 'A': [1584, 4379, 4387], 'study': [1585, 1831], 'employed': [1587], 'muscarinic': [1590], 'β-adrenergic': [1592], 'control': [1602, 1635], '(24Wong': [1605], 'S.K.F.': [1606], 'Ross': [1607], 'E.M.': [1608], '1994;': [1612, 1763, 2714], '269:': [1613], '18968-18976Abstract': [1614], 'Within': [1621, 3793], 'although': [1626], 'most': [1627], 'efficacy': [1637], '(25Gomeza': [1638, 1725], 'Joly': [1640, 1727, 1755, 2536, 2612, 2706, 3439, 3960, 4568], 'Kuhn': [1642, 1729, 4091], 'Knöpfel': [1644, 1731], '2199-2205Abstract': [1655, 1742], '(137)': [1663, 1750], '26Francesconi': [1666], 'Duvoisin': [1668], 'R.M.': [1669], '5615-5624Abstract': [1675], '(141)': [1683], '27Chang': [1686], 'W.': [1687, 4090], 'Chen': [1688], 'T.H.': [1689], 'Pratt': [1690], 'Shoback': [1692], '2000;': [1697, 2650, 4025], '19955-19963Abstract': [1699], '(80)': [1707], 'found': [1716, 4222], '28Pin': [1753], 'Heinemann': [1757, 2708], 'S.F.': [1758, 2709], '13:': [1764, 2715], '342-348Crossref': [1765, 2716], '(165)': [1768, 2719], '29Yamashita': [1771], 'Terakita': [1773], 'Shichida': [1775], '(Tokyo).': [1779], '2001;': [1780, 2032, 4046, 4101, 4125], '130:': [1781], '149-155Crossref': [1782], '(22)': [1785, 3589], 'Surprisingly,': [1788], 'identified': [1803], 'being': [1805, 4305], 'selectivity.': [1809], 'However,': [1810, 3387], 'part': [1812, 1819, 1865, 2748], 'recognizes': [1816], 'remains': [1825], 'elucidated.': [1828], 'present': [1830, 2405], 'was': [1832, 2012, 2081, 2201, 2296, 2307, 2375, 2491, 2514, 2590, 2756, 2840, 3009, 3093, 3154, 3260, 4186, 4221, 4246, 4250], 'aimed': [1833], 'identifying': [1835], 'recognized': [1846], 'mGluRs.': [1852, 4475], 'revealed': [1855, 3783, 4207], 'precisely': [1862], 'it,': [1867], 'what': [1891], 'proposed': [1894], 'supports': [1901], 'idea': [1903], 'two': [1908, 2248, 3815], 'classes': [1909], 'similar': [1915, 4200, 4256], 'way.': [1916], 'Materials—Chemicals': [1917], 'including': [1918], 'were': [1920, 1937, 1949, 1986, 2057, 2150, 2221, 2245, 2337, 2345, 2350, 2412, 2466, 2565, 2578, 2692, 2725, 2772, 2832, 2870, 3047, 3108, 3135, 3171, 3183, 3208, 3241, 3270, 3282, 4196, 4315, 4368, 4468, 4498], 'obtained': [1921, 4549], 'Sigma,': [1923], 'unless': [1924], 'otherwise': [1925], 'indicated.': [1926], 'Serum,': [1927], 'culture': [1928, 1936], 'media,': [1929], 'other': [1931], 'solutions': [1932], 'cell': [1935, 3150, 4204], 'Invitrogen.': [1939], 'plasmids': [1941, 2003], 'expressing': [1942, 2004, 4324, 4437], 'described': [1950, 2013, 2530, 2703, 3146], '(12Blahos': [1952, 3491, 3619, 3680, 3728], 'Gαq': [1984, 3319], 'kindly': [1987], 'Dr.': [1990], 'Bruce': [1991], 'Conklin': [1992, 3529], '(The': [1993], 'Gladstone': [1994], 'Institute,': [1995], 'San': [1996], 'Francisco,': [1997], 'CA).': [1998], 'generation': [2000], 'Gqo,': [2007], 'Gqz,': [2008, 3401], 'GqoCI,': [2009], 'GqzIC': [2011], '(30Blahos': [2015], 'Fischer': [2017], 'Stauffer': [2021, 4071], 'Rovelli': [2023, 4063, 4115], '3262-3269Abstract': [2034], '(45)': [2042], 'Culture': [2045], 'Transfection': [2047], 'Human': [2049], 'Embryonic': [2050], 'Kidney': [2051], '(HEK': [2052], '293)': [2053], 'Cells—HEK': [2054], 'cells': [2056, 2124, 2149, 2200, 2875, 3046, 3134, 3167, 3207, 4215, 4323, 4339, 4356, 4436], 'cultured': [2058, 3136], 'medium': [2063, 2323], '(DMEM)': [2064], '(Invitrogen)': [2065, 2234], 'supplemented': [2066, 2154, 3227], '10%': [2068, 2156, 2380], 'fetal': [2069, 2157, 3058], 'calf': [2070, 2158], 'serum': [2071, 2159], 'antibiotics': [2073, 2161], '(penicillin': [2074], 'streptomycin': [2076], '100': [2077], 'units/ml': [2078], 'final).': [2079], 'Electroporation': [2080], 'performed': [2082, 2913, 3010, 3261, 4212, 4418], 'total': [2085, 2898, 4404], 'volume': [2086], '300': [2088], 'μl': [2089], '4': [2091], 'μg': [2092, 2101, 2110], 'carrier': [2094], 'DNA,': [2095], 'mGluR': [2096], 'plasmid': [2098, 2117], 'DNA': [2099, 2118, 2845], '(4': [2100], 'mGlu4,': [2103, 2462, 3303, 3772, 4228], 'mGlu8,': [2104, 3304], 'chimera': [2107], '1.3': [2109], 'its': [2114, 4248], 'chimera),': [2115], 'Gα-subunit': [2116], '(2': [2119, 3218], 'μg),': [2120], '10': [2122, 2303, 2753, 3212, 3275], 'million': [2123, 2171], 'electroporation': [2126, 2140, 2226], 'buffer': [2127], '(50': [2128], 'mm': [2129, 2132, 2135, 2254, 2257, 2260, 2265, 2284], 'K2HPO4,': [2130], '20': [2131, 2134, 2264], 'CH3COOK,': [2133], 'KOH,': [2136], 'pH': [2137, 2267], '7.4).': [2138], 'After': [2139, 2289, 3061, 3101, 3148, 3204, 3232], '(260': [2141], 'V,': [2142], '1': [2143, 2272, 2278, 2287, 2741, 3099, 3790], 'millifarads,': [2144], 'Bio-Rad': [2145], 'Gene': [2146], 'Pulser': [2147], 'electroporator),': [2148], 'resuspended': [2151], 'DMEM': [2153, 2233, 3153, 3201], 'split': [2163], '12-well': [2165], 'clusters': [2166, 2336, 3161], '(Falcon,': [2167], 'Paris,': [2168], 'France)': [2169], '(10': [2170], 'cells/12': [2172], 'wells)': [2173], 'coated': [2174], 'poly-l-ornithine': [2177], '(15': [2178], 'μg/ml;': [2179], 'molecular': [2180], 'weight,': [2181], '40,000)': [2182], '(Sigma).': [2183], 'Determination': [2184], 'Inositol': [2186], 'Phosphate': [2187], '(IP)': [2188], 'Accumulation—The': [2189], 'procedure': [2190], 'determination': [2194], 'IP': [2196, 2400, 2868, 2892, 3359, 4336, 4399, 4429, 4523], 'accumulation': [2197, 3360], 'transfected': [2199, 3138, 3571], 'adapted': [2202, 3015], 'published': [2205], 'methods': [2206], '(31Berridge': [2207, 2355], 'M.J.': [2208, 2356], 'Irvine': [2209, 2357], 'R.F.': [2210, 2358], '1984;': [2212, 2360], '312:': [2213, 2361], '315-321Crossref': [2214, 2362], '(4249)': [2217, 2365], 'Cells': [2220, 2244, 4462], 'washed': [2222, 2247, 3172, 3209, 3272], '2–3': [2223], 'h': [2224, 2231, 3041], 'after': [2225, 2377, 2494, 2510, 3042, 3165, 3361, 3936], 'incubated': [2228, 2270, 3184, 3242], '14': [2230], '0.4': [2236], 'μCi/ml': [2237], '[3H]myo-inositol': [2238], '(23.4': [2239], 'Ci/mol)': [2240], '(PerkinElmer': [2241], 'Life': [2242], 'Sciences).': [2243], 'then': [2246, 2515, 3053, 3271], 'times': [2249, 3211, 3235, 3274], 'Hepes-buffered': [2251, 2275, 2293], 'saline': [2252, 2276], '(146': [2253], 'NaCl,': [2255], '4.2': [2256], 'KCl,': [2258], '0.5': [2259, 2325, 3077], 'MgCl2,': [2261], '0.1%': [2262], 'glucose,': [2263], 'Hepes,': [2266], '7.4)': [2268], 'ml': [2273, 2326], 'unit': [2279], 'GPT/ml': [2281], '2': [2283], 'pyruvate': [2285], 'h.': [2288, 3267], 'washing': [2290, 3233], 'once': [2291], 'saline,': [2294], 'LiCl': [2295], 'added': [2297], 'final': [2300], 'concentration': [2301], 'mm.': [2304], 'agonist': [2306, 4292, 4480, 4496], 'applied': [2308, 3094], 'min': [2310, 2316, 2388, 2429, 3063, 3097, 3213, 3276], 'later': [2311], 'left': [2313], '30': [2315, 2342, 2387, 3062, 3096], '37': [2318, 3179, 3186], '°C.': [2319, 3180], 'Replacing': [2320], 'incubation': [2322, 3259], 'perchloric': [2328], 'acid': [2329, 4285, 4490], '(5%)': [2330], 'stopped': [2331], 'reaction,': [2333], 'kept': [2338], 'ice': [2340], 'min.': [2343], 'Supernatants': [2344], 'recovered,': [2346], 'IPs': [2349], 'purified': [2351], 'Dowex': [2353], 'columns': [2354], 'Total': [2368], 'radioactivity': [2369, 2404, 2889, 2899, 4396, 4405], 'remaining': [2370], 'membrane': [2373, 2452], 'fraction': [2374, 2893, 4400], 'counted': [2376], 'treatment': [2378], 'Triton': [2381], 'X-100,': [2382], '0.1': [2383], 'n': [2384], 'NaOH': [2385], 'standard.': [2392], 'Results': [2393], 'expressed': [2395, 4197, 4423, 4517], 'percentage': [2398, 2887, 4426, 4520], 'produced': [2401], 'over': [2402], 'membranes.': [2408, 4408], 'dose-response': [2410], 'curves': [2411], 'fitted': [2413], 'according': [2414], 'equation': [2417], 'y': [2418, 2423, 2428], '=': [2419], '((y': [2420], 'max': [2421], '–': [2422, 2425, 2427], 'min)/1': [2424], '(x/EC50)n)': [2426], 'Kaleidagraph': [2432], 'program': [2433], '(Abelbeck': [2434], 'Software,': [2435], 'Reading,': [2436], 'PA).': [2437], 'Construction': [2438], 'Chimeric': [2440], 'Receptors—To': [2442], 'able': [2444], 'analyze': [2446], 'expression': [2448, 2667, 3004, 3474, 4138], 'correct': [2450, 2835], 'plasma': [2451], 'targeting': [2453], 'wild-type': [2456, 3140], 'chimeric': [2458, 3142, 3315, 3338, 3351, 3897, 4219], 'studied,': [2460], 'mGlu2,': [2461, 3665, 3771, 4231, 4341], 'mGlu8': [2464, 2563, 2761, 2802, 2825, 2856, 2926, 2938, 2966, 2978, 3760, 3774, 3918, 4544], 'first': [2467, 4187], 'epitope-tagged': [2468], 'N-terminal': [2471, 2795, 2808, 3933], 'end.': [2472], 'insertion': [2475], 'an': [2478, 2568, 3012, 3596, 3948, 3951, 4209], 'HA': [2479, 2569, 2573, 3929], 'c-Myc': [2481, 2575, 3927], 'epitope': [2482, 3930, 3949], 'MluI': [2488, 2512], 'restriction': [2489], 'site': [2490, 2513], 'introduced': [2492, 2516, 2592], 'just': [2493, 2593, 3935], 'signal': [2496, 3938], 'peptide': [2497], 'QuikChange™': [2500, 2766], 'technology': [2501, 2767], '(Stratagene': [2502], 'Europe,': [2503], 'Amsterdam,': [2504], 'Netherlands).': [2506], 'coding': [2508, 2523], 'place': [2518], 'equivalent': [2521, 3952], 'mGlu5': [2522, 2607, 3955], 'pRKG5-NHA': [2527], 'pRKG5-Nmyc': [2529], '(32Ango': [2532, 2608, 3956], 'Albani-Torregrossa': [2534, 2610, 3958], 'Robbe': [2538, 2614, 3962], 'Michel': [2540, 2616, 3964], 'J.-M.': [2541, 2617, 3965], 'Fagni': [2546, 2622, 2646, 3970, 4021, 4041], 'Neuropharmacology.': [2548, 2624, 3972], '38:': [2550, 2626, 3974], '793-803Crossref': [2551, 2627, 3975], '(53)': [2554, 2630, 3978], 'Using': [2557, 3001], 'strategy,': [2559], 'tagged': [2566], 'epitope,': [2570], 'whereas': [2571, 3388, 3666], 'generated.': [2579], 'case': [2582], 'receptor,': [2586], 'MRGSHis6': [2588], 'before': [2594], 'stop': [2596], 'codon.': [2597], 'three': [2600, 2911, 3210, 3234, 3273, 4242, 4415], 'receptors,': [2601, 2656, 4243], 'mGlu7': [2634, 4009], '(33Perroy': [2635, 4010], 'Prezeau': [2637, 4012], 'Waard': [2640, 4015], 'Shigemoto': [2642, 4017], 'Neurosci.': [2649, 4024, 4100], '20:': [2651, 4026, 4126], '7896-7904Crossref': [2652, 4027], 'presence': [2658, 3945], 'tag': [2661], 'did': [2662, 4233], 'not': [2663, 2982, 3465, 3567, 4234, 4287], 'modify': [2664], 'pharmacological': [2669, 4266], 'encoding': [2676], '(as': [2680, 2737], 'defined': [2681], 'Fig.': [2683, 2740, 4192], '1)': [2684], 'within': [2685, 4143], 'cDNA': [2691], 'swapped': [2693, 2757, 2922, 2962, 3911], 'PCR': [2699], 'overlap': [2700], 'methodology': [2701], '(28Pin': [2704], 'resulting': [2723, 2770], 'mGlu2/4i2': [2727, 4181, 4220, 4262, 4344, 4464], 'mGlu4/2i2.': [2729], 'indicated': [2738, 2878, 4439], 'horizontal': [2744], 'bar)': [2745], 'it': [2750, 3908, 4273], '(see': [2751, 3820], 'Figs.': [2752], '11)': [2755], 'cDNAs': [2763], '(Stratagene).': [2768], 'mGlu2/8i2': [2774], '(mGlu2': [2775, 3366], 'i2-loop': [2778, 2787], 'mGlu8)': [2781], 'mGlu8/2i2': [2783], '(mGlu8': [2784, 2805], 'mGlu2),': [2790], 'mGlu2-1st': [2791], '(mGlu2,': [2792], 'i2),': [2803, 2816], 'mGlu8-1st': [2804], 'mGlu2-VTA': [2818], 'mGlu8-AQR': [2820], 'VTA/AQR': [2830], 'sequences': [2831, 2932, 2972], 'swapped.': [2833], 'replacement': [2836], 'checked': [2841], 'double': [2843], 'strand': [2844], 'sequencing.Fig.': [2846], '10Differential': [2847], 'Gqz': [2852, 3296, 4185, 4236, 4348], 'mutants.': [2861], 'Basal': [2862], '(white': [2863], 'bars)and1mm': [2864], 'glutamate-induced': [2865], '(black': [2866], 'bars)': [2867], 'formations': [2869], 'determined': [2871], 'co-expressing': [2876, 4340, 4357, 4463], 'subunits.': [2883], 'Data': [2884, 4393], 'represent': [2885, 4394], 'compared': [2895], 'membranes': [2902], 'means': [2905, 4411, 4505], '±': [2906, 4412, 4506], 'S.E.': [2907, 4413, 4507], 'least': [2910], 'experiments': [2912, 4417], 'triplicate.': [2915], 'indicated:': [2928, 2968], 'bold': [2929, 2969], 'italic-underscore': [2931, 2971], 'correspond': [2933, 2973], 'portions.View': [2939], 'Large': [2940, 2988, 4443, 4529], 'Image': [2941, 2989, 4444, 4530], 'Figure': [2942, 2990, 4445, 4531], 'ViewerDownload': [2943, 2991, 4446, 4532], 'Hi-res': [2944, 2992, 4447, 4533], 'image': [2945, 2993, 4448, 4534], 'Download': [2946, 2994, 4449, 4535], '(PPT)Fig.': [2947, 4450], '11Summary': [2948], 'study.': [2955], 'portions,': [2979], 'respectively.': [2980], 'nd,': [2981], 'determined;': [2983], '–,': [2984], 'no': [2985], 'significant': [2986], 'effect.View': [2987], '(PPT)': [2995, 4536], 'Quantification': [2996], 'Surface': [2999], 'Receptors': [3000], 'ELISA—Determination': [3002], 'surface': [3007], 'ELISA': [3013, 3117, 4210], 'assay': [3014, 4211], 'Ref.': [3017, 3821], '34Zerangue': [3018], 'Schwappach': [3020], 'Jan': [3022, 3024], 'Y.N.': [3023], 'L.Y.': [3025], 'Neuron.': [3026], '22:': [3028], '537-548Abstract': [3029], '(902)': [3037], 'Scholar.': [3039], 'Twenty-four': [3040], 'transfection': [3043], '(10.106': [3044], 'cells),': [3045], 'fixed': [3048, 3221], '4%': [3050, 3223], 'paraformaldehyde': [3051, 3224], 'blocked': [3054], 'PBS': [3056, 3175, 3217, 3226], '–5%': [3057], 'bovine': [3059], 'serum.': [3060, 3203], 'reaction': [3065], 'primary': [3067, 3189], 'antibody': [3068, 3086, 3245], '(monoclonal': [3069], 'anti-HA': [3070, 3190], 'clone': [3071], '3F10': [3072], '(Roche': [3073], 'Applied': [3074], 'Science)': [3075], 'μg/ml)': [3078], 'same': [3081, 4376, 4560], 'buffer,': [3082], 'goat': [3084, 3248], 'anti-rat': [3085], 'coupled': [3087], 'horseradish': [3089], 'peroxidase': [3090], '(Jackson': [3091], 'ImmunoResearch)': [3092], 'μg/ml.': [3100], 'intense': [3102], 'washes': [3103], 'secondary': [3106, 3244], 'antibodies': [3107, 3197], 'detected': [3109], 'quantified': [3111], 'instantaneously': [3112], 'chemiluminescence': [3114], 'Supersignal®': [3116], 'femto': [3118], 'maximum': [3119], 'sensitivity': [3120], 'substrate': [3121], '(Pierce)': [3122], 'Wallac': [3125], 'Victor2': [3126], 'luminescence': [3127], 'counter.': [3128], 'Immunofluorescence': [3129], 'Assay': [3130], 'Non-permeabilized': [3132], 'Cells—The': [3133], 'previously.': [3147], 'transfection,': [3149, 3166], 'suspension': [3151], 'poured': [3155], 'coverslips': [3157, 3170, 3182, 3240], 'placed': [3158], '6-well': [3160], '(Falcon).': [3162], 'day': [3164], 'immobilized': [3168], 'twice': [3173], '(phosphate-buffered': [3176], 'saline)': [3177], 'Then': [3181], '°C': [3187], '(anti-HA-Roche-12CA5,': [3191], 'mouse)': [3192, 3196], 'anti-cMyc': [3194], '(anti-cMyc-Roche-9E10,': [3195], 'diluted': [3198, 3254], '1300': [3199], 'without': [3202], '1.5': [3205, 3266], 'h,': [3206], 'gelatin': [3215], 'g/liter)': [3219], '0.15': [3229], 'm': [3230], 'glucose.': [3231], 'PBS-glycin': [3237], '(0.1': [3238], 'm),': [3239], '(Cy™3-conjugated': [3246], 'AffiniPure': [3247], 'anti-mouse': [3249], 'IgG,': [3250], 'Jackson': [3251], 'ImmunoResearch': [3252], 'Laboratories)': [3253], '11000': [3255], 'PBS-gelatin.': [3257], 'dark': [3264], 'preparations': [3269], 'PBS-gelatin': [3278], 'fixed.': [3280], 'Pictures': [3281], 'taken': [3283], 'fluorescent': [3286], 'microscope': [3287], 'next': [3289], 'day.': [3290], 'Differential': [3291], 'Coupling': [3292], 'Their': [3298], 'Point': [3300], 'Mutants': [3301], 'Receptors—Many': [3307], 'Gi/o-coupled': [3308], 'activate': [3314, 3340, 3568, 4224, 4235], 'corresponding': [3317], 'replaced': [3327], 'those': [3329], 'Gαi2,': [3332], 'Gαo,': [3333, 3608], 'Gαz.': [3335], 'Since': [3336], 'C-β,': [3342], 'effective': [3344], 'easily': [3354], 'assessed': [3356], 'measuring': [3358], 'activation.': [3363], 'Group': [3364], 'II': [3365, 3408, 3563, 3804, 4484], '-3)': [3368], 'group': [3370, 3389, 3407, 3483, 3562, 3803, 3806, 4279, 4290, 4483, 4494], '(mGlu4,': [3372, 3392], '-6,': [3373], '-7,': [3374, 3393], '-8)': [3376, 3395], 'toxin-sensitive': [3382], 'Gαi/o': [3383], 'vivo.': [3386], 'Drosophila': [3409], 'mGluA': [3410], '(35Gomeza': [3416], 'Parmentier': [3422, 3828], 'M.-L.': [3423, 3829], 'Restituito': [3424, 3441, 3830, 4570], '923-930PubMed': [3434, 3840], '36Parmentier': [3437], 'M.L.': [3438, 4567], 'Grau': [3445, 4574], '53:': [3452, 4581], '778-786Crossref': [3453], '(70)': [3456], '(Fig.': [3459, 3762, 3851, 3920, 4216, 4238, 4259, 4294], '1).': [3460, 3763], 'differential': [3462], 'due': [3466], 'difference': [3469], 'our': [3482, 4541], 'previous': [3485], 'Western': [3488], 'blot': [3489], 'analysis': [3490, 4542], 'others': [3526], '(37Liu': [3527], 'Blin': [3531], 'Yun': [3533], '1995;': [3544], '92:': [3545], '11642-11646Crossref': [3546], '(198)': [3549], 'Moreover,': [3552], 'agreement': [3556], 'recent': [3559], 'demonstration': [3560], 'do': [3566], 'Gz': [3569], 'superior': [3572], 'cervical': [3573], 'ganglion': [3574], 'neurons': [3575], '(38Kammermeier': [3576], 'P.J.': [3577], 'Davis': [3578], 'M.I.': [3579], 'Ikeda': [3580], 'S.R.': [3581], '2003;': [3584, 3996], '63:': [3585], '183-191Crossref': [3586], '–4,': [3593], 'Ile': [3597, 3653, 3672], 'Gαz': [3599, 3616], 'toxin-ADP-ribosylated': [3603], 'Cys': [3604, 3656], 'Gαi': [3606], 'replacing': [3651], 'Gαqz': [3658, 4365], 'sufficient': [3660], 'allow': [3662], 'mutation': [3669], '(Cys': [3670], 'Gαqo)': [3674], 'suppresses': [3675], 'As': [3711, 4189, 4352], 'control,': [3714], 'all': [3715], 'activated': [3724, 4276, 4457], 'Sequence': [3764, 4142], 'Differences': [3765], 'Intracellular': [3768], 'Loops': [3769], 'Receptors—Analysis': [3775], 'highly': [3784], 'conserved': [3785, 3860], 'short': [3787], '3.': [3792], 'i1': [3795], 'single': [3798], 'mGluRs,': [3808], 'clearly': [3818], '35Gomeza': [3822], 'contrast,': [3844], 'variable': [3850], '2A),': [3852], 'region.': [3861], 'We': [3862, 3940, 4537], 'therefore': [3863], 'decided': [3864, 4538], 'α-subunit,': [3883], 'specifically,': [3886], 'constructed': [3893], 'series': [3895], '2B).': [3921], 'constructs': [3923], 'end,': [3934], 'peptide.': [3939], 'such': [3947], '39Fourgeaud': [3981], 'Bessis': [3983], 'A.-S.': [3984], 'Rossignol': [3985], 'Olivo': [3989], 'J.-c.': [3990], 'Hémar': [3991], '278:': [3997], '12222-12230Abstract': [3998], '(85)': [4006], '40Perroy': [4031], 'Gutierrez': [4033], 'G.J.': [4034], 'Coulon': [4035], 'V.': [4036, 4076], '45800-45805Abstract': [4048], '(23)': [4056], 'GABAB': [4060], '(41Pagano': [4061], 'Mosbacher': [4065], 'Lohmann': [4067], 'Duthey': [4069, 4109], 'Ristig': [4073], 'Schuler': [4075], 'Meigel': [4077], 'Lampert': [4079], 'Stein': [4081], 'Prézeau': [4083, 4119], 'Blahos': [4085, 4113], 'Froestl': [4089], 'Heid': [4093], 'Kaupmann': [4095], 'Bettler': [4097, 4117], '21:': [4102], '1189-1202Crossref': [4103], '42Galvez': [4107], 'Kniazeff': [4111], '2152-2159Crossref': [4127], '(315)': [4130], 'affect': [4134], 'neither': [4135], 'nor': [4139], 'pharmacology.': [4141], 'Loop': [4146], 'Recognizes': [4147], 'Extreme': [4149], 'Terminus': [4151], 'Subunit—To': [4154], 'examined.': [4188], '3a,': [4193], 'surface,': [4205], 'intact': [4214], '3a).': [4217], 'G-proteins,': [4226], 'like': [4227], 'unlike': [4230], '3b).': [4239], 'when': [4244], 'active,': [4247], 'effect': [4249], 'dose-dependent': [4251], 'always': [4253, 4548], 'displayed': [4254], 'EC50': [4257], 'value': [4258], '4).': [4260], 'retains': [4264], 'since': [4272], 'potently': [4275], 'II-selective': [4280], 'agonists': [4281, 4486], 'LY354740': [4282, 4487], '2R,4R-4-aminopyrrolydine-2,4-dicarboxylic': [4284, 4489], 'DL-AP4': [4293, 4497], '5).': [4295], 'highlight': [4298], 'enables': [4309], 'Gqz.': [4312], 'Unfortunately,': [4313], 'unable': [4316], 'obtain': [4318], 'enough': [4320], 'responses': [4321, 4553], 'chimera,': [4327], 'mGlu4/2i2,': [4328], 'any': [4330], 'tested': [4333], 'G-proteins.Fig.': [4334], '4Glutamate-induced': [4335], 'formation': [4337], 'proteins.': [4351], 'A,': [4355], 'Gαqo': [4361], '(open': [4362], 'circles)': [4363], '(closed': [4366], 'squares)': [4367], 'stimulated': [4369], 'increasing': [4371, 4501], 'concentrations': [4372], 'glutamate.': [4374], 'B,': [4375], 'C,': [4383], 'Same': [4384], 'chimerical': [4390], 'mGlu4/2i2': [4391], 'divided': [4401], 'Values': [4409, 4503], 'independent': [4416], 'triplicate': [4420, 4509], 'production': [4430, 4524], 'measured': [4431, 4525], 'under': [4432, 4526], 'basal': [4433, 4527], 'conditions': [4434], 'Gqo.View': [4442], '5mGlu2/4i2': [4451], 'co-expressed': [4453], 'agonists.': [4461], 'treated': [4469], 'compounds': [4472], 'acting': [4473], 'general': [4477], 'glutamate,': [4481], '(2R4R-APDC)': [4491], 'concentrations.': [4502], 'determinations': [4510], 'typical': [4513], 'experiment': [4514], 'conditions.View': [4528], 'pursue': [4540], 'because': [4546], 'robust': [4550], 'reproducible': [4552], 'shares': [4558], '(36Parmentier': [4566], '778-78': [4582]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2167739404', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-10T00:47:36.723877', 'created_date': '2016-06-24'}