Publication Information

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633, 748, 968, 981, 1046, 1235, 1240, 1319, 1462, 1536, 1720, 1770, 1939, 2386, 2668, 2699, 2800, 2938, 2950, 2960, 2969, 3059, 3064, 3108, 3145, 3191, 3265, 3291, 3299, 3311, 3429, 3454, 3460, 3480, 3526, 3575, 3590, 3595, 3764, 3847, 3887, 3894, 3942, 4027, 4054, 4112, 4121, 4142, 4177, 4207, 4212, 4220, 4234, 4245, 4257, 4278, 4283, 4367], 'the': [8, 21, 31, 40, 66, 73, 85, 93, 120, 127, 188, 201, 211, 220, 246, 253, 265, 273, 300, 307, 465, 472, 560, 584, 591, 645, 711, 722, 726, 742, 749, 774, 817, 820, 969, 972, 987, 1033, 1069, 1076, 1236, 1241, 1306, 1315, 1320, 1345, 1349, 1359, 1373, 1422, 1440, 1451, 1597, 1614, 1627, 1636, 1639, 1664, 1667, 1674, 1677, 1686, 1700, 1763, 1771, 1775, 1781, 1791, 1819, 1829, 1852, 1895, 1908, 1925, 1936, 1940, 1949, 1962, 1968, 1993, 2007, 2023, 2037, 2040, 2086, 2126, 2256, 2338, 2384, 2392, 2661, 2669, 2677, 2770, 2806, 2860, 3085, 3132, 3192, 3207, 3260, 3270, 3292, 3315, 3327, 3333, 3400, 3412, 3430, 3455, 3461, 3486, 3489, 3522, 3527, 3560, 3571, 3578, 3582, 3591, 3596, 3633, 3649, 3671, 3674, 3685, 3712, 3731, 3735, 3765, 3774, 3798, 3801, 3804, 3815, 3820, 3825, 3829, 3843, 3853, 3882, 3888, 3895, 4043, 4061, 4110, 4113, 4134, 4159, 4164, 4172, 4178, 4184, 4208, 4235, 4246, 4252, 4258, 4279, 4374], 'retinal': [9, 22, 173, 189, 202, 353, 395, 402, 440, 447, 473, 1258, 1340, 1408, 3637], 'pigmented': [10, 23, 190, 203, 396, 441, 474], 'epithelial': [11, 191], 'cells': [12, 192, 1981], 'and': [13, 45, 57, 81, 124, 135, 147, 175, 193, 225, 237, 261, 304, 315, 327, 355, 471, 649, 705, 718, 733, 762, 814, 822, 834, 899, 905, 971, 1018, 1051, 1075, 1199, 1252, 1297, 1322, 1355, 1392, 1410, 1429, 1435, 1448, 1457, 1465, 1543, 1569, 1599, 1685, 1707, 1747, 1779, 1812, 1825, 1863, 1928, 1952, 1954, 1964, 1983, 2085, 2128, 2246, 2255, 2265, 2290, 2305, 2337, 2363, 2369, 2408, 2587, 2611, 2631, 2663, 2671, 2680, 2693, 2703, 2705, 2727, 2752, 2772, 2904, 2911, 2957, 2983, 3102, 3129, 3159, 3167, 3177, 3245, 3281, 3320, 3341, 3405, 3411, 3417, 3451, 3557, 3564, 3609, 3618, 3673, 3700, 3702, 3722, 3745, 3758, 3776, 3779, 3787, 3795, 3803, 3808, 3840, 3850, 3906, 3913, 3919, 4029, 4033, 4050, 4124, 4152, 4166, 4200, 4214, 4276, 4281, 4295, 4300], 'liver,': [14, 121, 194, 301, 466, 3318], 'converts': [15, 195, 454], 'all-trans-retinol': [16, 129, 196, 309, 455, 717, 728, 1121, 1383, 4099, 4206, 4277], 'into': [17, 197, 1635, 1804, 1894, 1979, 2260, 3373], 'all-trans-retinyl': [18, 117, 198, 297, 459, 1385, 4058, 4067, 4084, 4138, 4175, 4185, 4230], 'esters.': [19, 199, 4059], 'In': [20, 200, 698, 710, 725, 819, 1671, 2102, 3326, 3747, 4131], 'epithelium,': [24, 204], 'LRAT': [25, 69, 205, 249, 557, 732, 862, 989, 1011, 1036, 1101, 1168, 1193, 1242, 1308, 1318, 1350, 3304, 4256], 'plays': [26, 206], 'a': [27, 34, 59, 207, 214, 239, 595, 634, 745, 764, 771, 867, 964, 1038, 1041, 1110, 1113, 1203, 1298, 1475, 1554, 1583, 1588, 1651, 1693, 1958, 2269, 2301, 2371, 2591, 2607, 2700, 2720, 2812, 2884, 2900, 2925, 3038, 3126, 3170, 3188, 3212, 3253, 3342, 3349, 3356, 3507, 3761, 3811, 4368], 'key': [28, 208, 1233], 'role': [29, 209, 1234, 3523], 'retinoid': [32, 212, 1237, 1253, 4044], 'cycle,': [33, 213, 700, 1238], 'two-cell': [35, 215], 'recycling': [36, 216], 'system': [37, 217, 2682, 3529], 'that': [38, 92, 145, 160, 218, 272, 325, 340, 642, 768, 1103, 1314, 1655, 1735, 3257], 'replenishes': [39, 219], '11-cis-retinal': [41, 221, 827, 3925, 4039], 'chromophore': [42, 222, 646], 'of': [43, 68, 84, 102, 116, 223, 248, 264, 282, 296, 372, 417, 647, 1014, 1040, 1065, 1098, 1104, 1196, 1231, 1256, 1317, 1347, 1372, 1377, 1382, 1424, 1427, 1439, 1450, 1453, 1494, 1540, 1545, 1608, 1623, 1638, 1666, 1676, 1680, 1699, 1712, 1754, 1760, 1774, 1818, 1849, 1887, 1932, 1943, 1957, 1967, 1992, 2039, 2125, 2279, 2379, 2410, 2594, 2627, 2722, 2797, 2805, 2814, 3087, 3284, 3332, 3336, 3355, 3403, 3425, 3432, 3447, 3466, 3524, 3530, 3559, 3569, 3577, 3593, 3632, 3635, 3655, 3662, 3670, 3687, 3711, 3734, 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3672, 3781, 3789], 'for': [87, 267, 400, 445, 565, 744, 763, 773, 986, 1167, 1406, 1411, 1455, 1560, 1873, 1878, 1883, 2119, 2307, 2324, 2353, 2753, 2785, 2795, 2867, 2943, 3077, 3084, 3115, 3143, 3485], '6–8-week-old': [88, 268], 'mice': [90, 112, 162, 270, 292, 342, 1357, 1379, 1400, 1533, 1809, 1891, 2051, 2696, 3378, 3434, 3468, 3497, 3537, 3600, 3605, 3627, 3657, 3664, 3683, 3721, 3724, 3849, 3891, 3912, 3936, 4052, 4065, 4077, 4093, 4170, 4190, 4197, 4216, 4222, 4239, 4284, 4378], 'revealed': [91, 144, 271, 324, 1102, 3442, 3677], 'rod': [94, 146, 274, 326, 391, 436, 821, 2815], 'outer': [95, 275, 392, 437, 825, 3615], 'segments': [96, 276], 'are': [97, 151, 277, 331, 630, 1244, 1333, 1396, 1401, 3478, 3504, 3601, 3698, 3704, 3752, 3858, 3933, 4291], '∼35%': [98, 278, 3588], 'shorter': [99, 279, 3688, 3699], 'than': [100, 280, 567], 'those': [101, 281, 3661, 4194], 'Lrat+/+': [103, 283, 2127, 3467, 3604, 3663, 3911, 4028, 4049, 4064, 4196, 4213], 'mice,': [104, 284, 1485, 3364, 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[139, 319], 'pupillary': [141, 321, 387, 432], 'constriction': [142, 322], 'analyses': [143, 323, 4045, 4089], 'visual': [149, 329, 1331], 'functions': [150, 330, 1332], 'severely': [152, 332, 1334], 'attenuated': [153, 333], 'at': [154, 334, 2310, 2321, 2327, 2350, 2388, 2590, 2599, 2781, 2868, 2980, 3074, 3081, 3118, 3206, 3215, 3506, 3581, 3730, 4100], 'early': [156, 170, 336, 350, 1337], 'age.': [157, 337], 'conclude': [159, 339], 'may': [163, 343], 'serve': [164, 344], 'animal': [167, 347, 1416], 'model': [168, 348, 1405, 2813], 'with': [169, 349, 829, 1027, 1564, 1613, 1626, 1762, 1851, 1860, 1987, 2248, 2276, 2300, 2583, 2597, 2606, 2636, 2651, 2676, 2749, 2811, 2908, 2947, 2966, 3037, 3095, 3105, 3136, 3154, 3169, 3379, 3521, 3603, 3684, 3756, 3903, 3935, 4193, 4251], 'onset': [171, 351, 1338], 'severe': [172, 176, 352, 356, 1248, 1339], 'dystrophy': [174, 354, 1259], 'retinyl': [177, 357, 765], 'ester': [178, 358, 766, 4186, 4247], 'deprivation.': [179, 359, 1414], '(LRAT)': [362], '1The': [363], 'abbreviations': [364, 409], 'used': [365, 410, 1535, 1559, 2048, 2238, 2794, 3941], 'are:': [366, 411], 'LRAT,': [367, 412, 3269], 'lecithin-retinol': [368, 413], 'acyltransferase;': [369, 414], 'ANOVA,': [370, 415], 'variance;': [373, 418], 'BisTris,': [374, 419], '2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol;': [375, 420], 'ERG,': [376, 421], 'electroretinogram;': [377, 422], 'HPLC,': [378, 423], 'high': [379, 424, 4253], 'performance': [380, 425], 'liquid': [381, 426, 2032], 'chromatography;': [382, 427], 'PIPES,': [383, 428, 3067], '1,4-piperazinediethanesulfonic': [384, 429], 'acid;': [385, 430], 'PLR,': [386, 431], 'light': [388, 433, 1473, 2140, 2689, 2729, 2876, 2933, 2986, 3583, 3693, 3880, 4375], 'response(s);': [389, 434], 'ROS,': [390, 435], 'segment(s);': [393, 438], 'RPE,': [394, 439, 727, 970], 'epithelium;': [397, 442], 'Rpe65,': [398, 443], '65-kDa': [401, 446], 'pigment': [403, 448], 'epithelium': [404, 449, 475], 'cell': [405, 450, 1800, 3369], 'protein;': [406, 451], 'WT,': [407, 452], 'wild-type.1The': [408], 'wild-type.': [453], '(vitamin': [456], 'A)': [457], 'to': [458, 716, 721, 740, 812, 816, 831, 962, 1021, 1120, 1246, 1437, 1663, 1732, 1935, 2035, 2049, 2405, 2708, 2735, 2740, 2744, 2790, 2873, 2985, 3131, 3165, 3184, 3267, 3513, 3622, 4035], 'several': [462, 982], 'including': [464, 3314], 'pancreas,': [468], 'intestine,': [469], 'testis,': [470, 3317], '(RPE)': [476], '(1Saari': [477], 'J.C.': [478, 688, 2223, 3969], 'Bredberg': [479], 'D.L.': [480], 'Farrell': [481], 'D.F.': [482], 'Biochem.': [483, 511, 918, 1001], 'J.': [484, 529, 545, 572, 612, 883, 919, 930, 944, 1002, 1144, 1176, 2069, 2195, 2219, 2477, 2518, 2543, 3008, 3231, 3958, 4264], '1993;': [485, 499], '291:': [486], '697-700Crossref': [487], 'PubMed': [488, 502, 518, 538, 554, 578, 623, 671, 757, 802, 856, 894, 923, 935, 955, 1006, 1091, 1134, 1154, 1186, 1288, 1526, 2080, 2110, 2173, 2206, 2228, 2451, 2488, 2529, 2554, 2850, 3019, 3242, 3551, 3963, 3982, 4019, 4269], 'Scopus': [489, 503, 519, 579, 624, 672, 758, 803, 857, 895, 936, 1092, 1135, 1155, 1187, 1289, 1527, 2081, 2111, 2174, 2207, 2229, 2452, 2489, 2530, 2555, 2851, 3020, 3552, 3964, 3983, 4020, 4270], '(54)': [490], 'Google': [491, 505, 521, 539, 555, 581, 626, 674, 685, 696, 760, 805, 859, 897, 924, 938, 956, 1007, 1094, 1137, 1157, 1189, 1228, 1291, 1529, 2083, 2113, 2176, 2209, 2231, 2454, 2491, 2532, 2557, 2853, 3022, 3243, 3554, 3966, 3985, 4022, 4272], 'Scholar,': [492, 506, 522, 540, 675, 686, 925, 939, 1138, 2177, 2210, 2455, 2492, 2533, 3967, 3986], '2Schmitt': [493], 'M.C.': [494], 'Ong': [495, 509, 543], 'D.E.': [496, 510, 524, 544], 'Biol.': [497, 530, 546, 613, 884, 1059, 2070, 2106, 2196, 2478, 2519, 2544, 3009, 4015], 'Reprod.': [498], '49:': [500], '972-979Crossref': [501], '(38)': [504], '3MacDonald': [507], 'P.N.': [508, 526, 542], 'Biophys.': [512], 'Res.': [513, 667, 852, 946, 3233, 3978], 'Commun.': [514], '1988;': [515, 532, 548], '156:': [516], '157-163Crossref': [517], '(90)': [520], '4Ong': [523], 'MacDonald': [525], 'Gubitosi': [527], 'A.M.': [528], 'Chem.': [531, 547, 614, 885, 2071, 2197, 2479, 2520, 2545, 3010], '263:': [533, 549], '5789-5796Abstract': [534], 'Full': [535, 551, 618, 620, 889, 891, 950, 952, 2075, 2077, 2201, 2203, 2483, 2485, 2524, 2526, 2549, 2551, 3014, 3016, 3237, 3239], 'Text': [536, 552, 619, 621, 890, 892, 951, 953, 2076, 2078, 2202, 2204, 2484, 2486, 2525, 2527, 2550, 2552, 3015, 3017, 3238, 3240], 'PDF': [537, 553, 622, 893, 954, 2079, 2205, 2487, 2528, 2553, 3018, 3241], '5MacDonald': [541], '12478-12482Abstract': [550], 'Scholar).': [556, 627, 697, 806, 860, 957, 1008, 1062, 1095, 1158, 1190, 1229, 1292, 1530, 2114, 2232, 2558, 2854, 3023, 3555, 4023], 'activity': [558, 990, 1170, 4254], 'RPE': [561, 750, 1376, 1905, 3675, 3713, 3775, 3802, 4143, 4179], 'has': [562, 1780, 3276], 'been': [563, 738, 2991, 3309], 'studied': [564, 4380], 'more': [566, 2343], '60': [568, 1876], 'years': [569], '(6Wald': [570], 'G.': [571, 2095], 'Gen.': [573], 'Physiol.': [574], '1936;': [575], '19:': [576], '781-795Crossref': [577], '(16)': [580], 'Scholar),': [582, 2084], 'but': [583], 'was': [586, 864, 960, 1551, 1562, 1579, 1592, 1633, 1650, 1690, 1703, 1730, 1741, 1858, 1916, 1946, 1977, 1985, 1999, 2014, 2047, 2089, 2117, 2274, 2298, 2318, 2335, 2340, 2381, 2658, 2691, 2732, 2890, 3346, 3397, 3491, 4232, 4297], 'recently': [588], 'identified': [589, 1162, 1261, 1788, 1859, 3310, 3398, 3900], 'on': [590, 976, 1032, 1206, 1250, 1446, 1790, 2268, 2660, 3881], 'molecular': [592, 3445], 'level': [593, 4056], '25-kDa': [596], 'integral': [597, 1024], 'membrane': [598, 1025], 'protein': [599, 1026, 1996, 2013, 2046], '(7Ruiz': [600, 871], 'A.': [601, 603, 872, 874, 915, 998, 1125, 1142, 1174, 1210, 1282, 2169, 2447, 2846], 'Winston': [602, 873], 'Lim': [604, 875], 'Y.H.': [605, 876], 'Gilbert': [606, 877], 'B.A.': [607, 878], 'Rando': [608, 879, 1085, 1128, 1147, 1179], 'R.R.': [609, 752, 880, 1086, 1129, 1148, 1180], 'Bok': [610, 881, 1126, 1145, 1177, 1219, 1507], 'D.': [611, 677, 882, 1127, 1146, 1178, 1220, 1508, 1510], '1999;': [615, 886, 2225, 3548], '274:': [616, 887], '3834-3841Abstract': [617, 888], '(211)': [625, 896], 'All-trans-retinyl': [628, 735, 4116], 'intermediate': [631], 'compounds': [632], 'metabolic': [635], 'pathway': [636], '(“visual': [637], 'cycle”': [638], 'or': [639, 1384, 1837, 2262, 2761, 3459], '“retinoid': [640], 'cycle”)': [641], 'recycles': [643], '11-cis-retinal,': [644, 813], 'pigments': [651, 707, 836], '(for': [652, 777, 837], 'review,': [653, 778, 838], 'see': [654, 779, 839, 3324], 'Refs.': [655], '8McBee': [656, 841], 'J.K.': [657, 782, 842, 2186, 2535], 'Palczewski': [658, 796, 843, 2067, 2161, 2193, 2439, 2475, 2516, 2541, 2838, 3006, 3956, 3975, 4007], 'K.': [659, 797, 844, 1520, 2068, 2162, 2194, 2212, 2440, 2476, 2517, 2542, 2839, 3007, 3539, 3957, 3976, 3992, 4008, 4010], 'Baehr': [660, 845], 'W.': [661, 846], 'Pepperberg': [662, 847], 'D.R.': [663, 848], 'Prog.': [664, 849], 'Retin.': [665, 850], 'Eye': [666, 851], '2001;': [668, 853, 1151, 1183, 1225, 1285, 2198, 2546], '20:': [669, 854, 1524, 4017], '469-529Crossref': [670, 855], '(314)': [673, 858], '9Bok': [676], 'Investig.': [678, 689, 1221], 'Ophthalmol.': [679, 690, 1222], 'Vis.': [680, 691, 1223], 'Sci.': [681, 692, 1224, 2166, 2444, 2843], '1985;': [682], '26:': [683], '1659-1694PubMed': [684], '10Saari': [687], '2000;': [693, 799, 947, 1131, 2170, 2448, 2847, 3234, 4016], '41:': [694, 948, 3235], '337-348PubMed': [695], 'this': [699, 1066, 1672], 'all-trans-retinal': [701, 713], 'dissociates': [702], 'from': [703, 866, 903, 1487, 1553, 1657, 2412, 2713, 3562, 3660, 3871, 3878, 4042, 4063, 4075, 4109, 4149, 4163, 4195, 4285], 'after': [708, 2370, 2779], 'photobleaching.': [709], 'photoreceptors,': [712], 'subsequently': [719], 'exported': [720, 815], 'adjacent': [723], 'RPE.': [724], 'esterified': [730], 'stored.': [734], 'suggested': [739], 'be': [741, 963, 1022, 3185, 3204, 3514, 3623], 'substrate': [743, 772], 'putative': [746, 775], 'isomerohydrolase': [747], '(11Rando': [751], 'Biochemistry.': [753, 798, 1087, 1130, 2224], '1991;': [754], '30:': [755], '595-602Crossref': [756], '(76)': [759], 'Scholar)': [761, 898, 3244], 'hydrolase': [767], 'produces': [769], 'all-trans-retinol,': [770], 'isomerase': [776], 'Ref.': [780, 840], '12McBee': [781], 'Kuksa': [783, 2153, 2183, 2431, 2463, 2830], 'V.': [784, 1055, 2154, 2184, 2432, 2464, 2494, 2831, 3541], 'Alvarez': [785], 'R.': [786, 909, 927, 941, 992, 3228, 4261], 'de': [787], 'Lera': [788], 'A.R.': [789], 'Prezhdo': [790], 'O.': [791], 'Haeseleer': [792], 'F.': [793, 2056, 2470, 2496, 2995], 'Sokal': [794], 'I.': [795], '39:': [800, 1132], '11370-11380Crossref': [801], '(87)': [804], 'Ultimately,': [807], '11-cis-retinol': [808], 'produced,': [810], 'oxidized': [811], 'photoreceptors.': [818], 'photoreceptor': [824, 3768, 3805], 'segments,': [826], 'recombines': [828], 'opsins': [830], 'form': [832], 'Human': [861], 'cDNA': [863, 869, 902, 1915, 3225], 'cloned': [865, 1955], 'retinal-RPE': [868], 'library': [870], 'rodent': [900], 'liver': [904, 1321, 3462, 4165, 4280, 4304, 4314, 4324, 4356], 'tissues': [907, 984, 1324], '(13Zolfaghari': [908, 991], 'Wang': [910, 993], 'Y.': [911, 994, 1270, 2060, 2460, 2509, 2999], 'Chen': [912, 995, 1511, 2218], 'Q.': [913, 996], 'Sancher': [914, 997], 'Ross': [916, 928, 942, 999, 3229, 4262], 'A.C.': [917, 929, 943, 1000, 3230, 4263], '2002;': [920, 932, 1003, 2072, 2480, 2521, 3011, 4266], '368:': [921, 1004], '621-631Crossref': [922, 1005], '14Zolfaghari': [926], 'Nutr.': [931, 4265], '132:': [933, 4267], '1160-1164Crossref': [934, 4268], '(43)': [937, 4271], '15Zolfaghari': [940], 'Lipid': [945, 3232], '2024-2034Abstract': [949, 3236], 'mRNA': [959], 'shown': [961], '5.0-kb': [965], 'species': [966], 'expressed': [967, 3247, 3305], 'transcripts': [974], 'based': [975, 1789], 'differential': [977], 'polyadenylation': [978], 'were': [979, 1460, 1468, 1496, 1534, 1726, 1787, 1802, 1810, 1841, 1870, 1892, 2027, 2135, 2237, 2244, 2253, 2258, 2348, 2366, 2416, 2563, 2571, 2617, 2649, 2666, 2674, 2697, 2711, 2747, 2758, 2765, 2777, 2793, 2809, 2857, 2865, 2878, 2897, 2906, 2922, 2936, 2978, 3025, 3035, 3054, 3092, 3123, 3141, 3152, 3371, 3383, 3658, 3892, 3899, 3926, 4031, 4118, 4128, 4140, 4191, 4210, 4379], 'detected': [980], 'known': [985], 'highest': [988], 'human': [1010, 1100, 1192, 1407, 3268], 'polypeptide': [1012, 1941], 'consisted': [1013], '230': [1015], 'amino': [1016], 'acids': [1017], 'predicted': [1020, 1245], 'two': [1028, 1163, 1262, 2234, 3285, 3443, 3645], 'transmembrane': [1029], 'domains.': [1030], 'Based': [1031], 'primary': [1034], 'sequence,': [1035], 'member': [1039], 'large': [1042], 'N1pC/P60': [1043], 'superfamily': [1044], 'involved': [1045], 'murein': [1047], 'degradation,': [1048], 'amide': [1049], 'hydrolysis,': [1050], 'acyl': [1052], 'transfer': [1053], '(16Anantharaman': [1054], 'Aravind': [1056], 'L.': [1057, 1084], 'Genome': [1058], '2003;': [1060, 1088, 3960], 'http://genomebiology.com/2003/2/3/reviews/0011Google': [1061], 'Eukaryotic': [1063], 'members': [1064], 'family': [1067], 'include': [1068], 'class': [1070], 'II': [1071], 'tumor': [1072], 'suppressor': [1073], 'genes': [1074], 'nematode': [1077], 'developmental': [1078], 'regulator': [1079], 'Egl-26': [1080], '(17Jahng': [1081], 'W.J.': [1082], 'Xue': [1083], '42:': [1089, 1226], '12805-12812Crossref': [1090], '(37)': [1093], 'Site-specific': [1096], 'mutagenesis': [1097, 1160], 'recombinant': [1099, 2041], 'four': [1105, 2263, 2789], 'Cys': [1106], 'residues,': [1107], 'Cys161': [1108], 'nucleophile': [1111], 'creating': [1112], 'thioacylenzyme': [1114], 'intermediate,': [1115], 'which': [1116, 1591, 3469, 4105], 'then': [1118, 1708, 2319, 2958, 3080, 3093], 'transferred': [1119], '(18Mondal': [1122], 'M.S.': [1123, 1140, 1172], 'Ruiz': [1124, 1141, 1173], '5215-5220Crossref': [1133], '(42)': [1136], '19Mondal': [1139], 'Hu': [1143, 1175], 'FEBS': [1149, 1181], 'Lett.': [1150, 1182], '489:': [1152, 1184], '14-18Crossref': [1153, 1185], '(15)': [1156, 1188], 'Further': [1159], 'experiments': [1161, 1417], 'His': [1164], 'residues': [1165, 1937], 'essential': [1166], 'catalytic': [1169], '(19Mondal': [1171], 'consists': [1195, 3282], 'three': [1197, 2261], 'exons': [1198], 'located': [1201, 1604, 1619, 1752, 1769, 1845], 'single': [1204, 3189], 'copy': [1205, 3190], 'chromosome': [1207], '4q31.2': [1208], '(20Ruiz': [1209], 'Kuehn': [1211], 'M.H.': [1212, 2513], 'Andorf': [1213], 'J.L.': [1214], 'Stone': [1215, 2157, 2435, 2834], 'E.': [1216, 1280, 1506, 2502], 'Hageman': [1217], 'G.S.': [1218], '31-37PubMed': [1227], 'Because': [1230], 'its': [1232, 2120], 'defects': [1239], 'consequences': [1249, 1346], 'vision': [1251], 'metabolism.': [1254], 'Screening': [1255], '267': [1257], 'patients': [1260], 'disease-associated': [1263], 'mutations': [1264], 'inherited': [1265], 'recessively': [1266], '(21Thompson': [1267], 'D.A.': [1268], 'Li': [1269], 'McHenry': [1271], 'C.L.': [1272], 'Carlson': [1273], 'T.J.': [1274], 'Ding': [1275], 'X.': [1276], 'Sieving': [1277], 'P.A.': [1278, 2101], 'Apfelstedt-Sylla': [1279], 'Gal': [1281], 'Nat.': [1283, 1521, 3546], 'Genet.': [1284, 1522, 3547], '28:': [1286], '123-124Crossref': [1287], '(152)': [1290], 'missense': [1294], 'mutation': [1295, 1300], 'S175R': [1296, 1307], 'frameshift': [1299], '396delAA': [1301], 'inactivated': [1302], 'LRAT.': [1303], 'Patients': [1304], 'carrying': [1305], 'null': [1309], 'developed': [1311, 3739], 'normally,': [1312, 3499], 'suggesting': [1313], 'lack': [1316, 4173], 'had': [1325, 1736, 2719], 'no': [1326, 1389, 2766, 3277, 3640, 3678, 4125], 'deleterious': [1327], 'effects.': [1328], 'However,': [1329], 'their': [1330, 4055], 'attenuated,': [1335], 'causing': [1336], 'dystrophy.': [1341], 'To': [1342, 3361], 'characterize': [1343], 'further': [1344], 'deleting': [1348], 'gene,': [1351], 'we': [1352], 'Lrat+/-': [1354, 1826, 3563, 3656, 3792, 3914, 4030, 4051, 4076, 4189, 4215], 'standard': [1360, 3386], 'replacement': [1362], 'technique.': [1363], 'animals': [1368, 2792], 'exhibit': [1369], 'slow': [1370], 'degeneration': [1371], 'retina.': [1374], 'devoid': [1381], 'esters,': [1386], 'photoreceptors': [1387, 3736, 3821, 3830], 'functional': [1390, 3357], 'rhodopsin,': [1391], 'electroretinogram': [1393], '(ERG)': [1394], 'responses': [1395, 2707, 2776, 2808, 2877], 'highly': [1397], 'attenuated.': [1398], 'important': [1403], 'experimental': [1404, 2402, 3650], 'dystrophies': [1409], 'vitamin': [1412, 3535], 'A': [1413, 1930, 2654, 3608, 3778, 3794, 4225], 'Animals—All': [1415], 'employed': [1418], 'procedures': [1419, 2134, 2403, 2989, 3388], 'approved': [1420], 'University': [1423, 1426, 1431], 'Washington,': [1425], 'Utah,': [1428], 'Washington': [1430], 'Animal': [1432], 'Care': [1433], 'Committees': [1434], 'conformed': [1436], 'recommendations': [1438, 1449], 'American': [1441], 'Veterinary': [1442], 'Medical': [1443], 'Association': [1444, 1452], 'Panel': [1445], 'Euthanasia': [1447], 'Research': [1454], 'Vision': [1456, 3977], 'Ophthalmology.': [1458], 'Animals': [1459], 'maintained': [1461], 'complete': [1463], 'darkness,': [1464], 'all': [1466, 1537, 2801, 3890, 4132], 'manipulations': [1467], 'done': [1469, 1742], 'under': [1470, 2137, 2566, 2880, 3027, 3838], 'dim': [1471, 2138, 2567], 'red': [1472, 2139, 2568], 'employing': [1474, 3534], 'Kodak': [1476], 'no.': [1477], '1': [1478, 1610, 1682, 2741, 2870, 3116, 3338], 'safelight': [1479], 'filter': [1480], '(transmittance': [1481], '>560': [1482], 'nm).': [1483], 'Rpe65-/-': [1484], 'obtained': [1486, 2712], 'Dr.': [1488], 'M.': [1489, 2064, 2504, 3003], 'Redmond': [1490], '(NEI,': [1491], 'National': [1492], 'Institutes': [1493], 'Health),': [1495], 'genotyped': [1497], 'described': [1499, 2053, 2142, 2420, 2819, 2992, 3837], 'previously': [1500, 2143, 2421, 2820, 2993], '(22Redmond': [1501], 'T.M.': [1502], 'Yu': [1503], 'S.': [1504, 2168, 2446, 2511, 2845, 3953], 'Lee': [1505], 'Hamasaki': [1509], 'N.': [1512], 'Goletz': [1513], 'P.': [1514, 3543, 3545], 'Ma': [1515], 'J.X.': [1516], 'Crouch': [1517], 'R.K.': [1518], 'Pfeifer': [1519], '1998;': [1523, 3979], '344-351Crossref': [1525], '(773)': [1528], 'Typically,': [1531, 2233, 2788, 4060], '6–12-week-old': [1532], 'experiments.': [1538], 'Construction': [1539], 'Targeting': [1541, 3178], 'Vector': [1542], 'Generation': [1544], 'Mice—A': [1547], '∼14-kb': [1548], 'genomic': [1549, 1653], 'clone': [1550], 'isolated': [1552, 1903], '129SvEvλ': [1555], 'library.': [1556], 'probe': [1558], 'screening': [1561], 'amplified': [1563, 1595, 1917, 1947], 'PCR': [1565, 1593, 1728, 1740, 1793, 1868], 'primers': [1566, 1926, 1950], 'LRAT2': [1567], '(5′-GACGTGTTGGAGGTGTCACGGAC-3′)': [1568], 'LRAT4': [1570], '(5′-CTTGTGTGTGCAGACCAAGATGAC-3′),': [1571], 'fragment': [1572, 1586, 1654, 1931, 1991, 3408], 'size': [1573], '660': [1574], 'bp.': [1575], 'targeting': [1577, 1701, 3329], 'vector': [1578, 1702, 1972], 'constructed': [1580], 'using': [1582, 1596, 1643, 1743, 1907, 1918, 1924, 1948, 2006, 2391, 2602, 2622, 2859, 2883, 2924, 3399, 3415, 4381], '1,350-bp': [1584], 'DNA': [1585], 'short': [1589, 1631, 1755], 'arm,': [1590, 1756], 'product': [1594, 3358], 'LRATSA1': [1598, 1602], 'LRATSA2': [1600, 1617], 'primers.': [1601], '3.6': [1605], 'kb': [1606, 1621], 'upstream': [1607, 1622, 1688, 1759, 3261, 3278, 3344], 'exon': [1609, 1624, 1661, 1681, 3280, 3337], '(containing': [1611, 3218], 'ATG),': [1612], 'sequence': [1615, 1628, 1679, 1689, 1764, 1782, 1853, 1942, 3202, 3226, 3248, 3290, 3306, 3335, 3345], '5′-GTACCCAGGAGTAGGACCAAC-3′.': [1616], '2.2': [1620], '1,': [1625], '5′-TGTGAGTGAGAGGCCACATCC-3′.': [1629], 'arm': [1632, 1649], 'inserted': [1634], '5′-end': [1637], 'Neo': [1640, 1694, 1776, 3350], 'cassette': [1642, 1778], 'MluI': [1645], 'site.': [1646], 'long': [1648], '10-kb': [1652], 'starts': [1656], 'SmaI': [1658], 'site': [1659, 3210], '(inside': [1660], '1)': [1662], 'end': [1665], '14-kb': [1668], 'λ': [1669], 'clone.': [1670], 'strategy,': [1673], 'part': [1675, 3331], 'coding': [1678, 3286, 3334], '(including': [1683, 3339], 'ATG)': [1684, 3340], '2.2-kb': [1687, 3343], 'replaced': [1691, 3347], 'cassette.': [1696], '10': [1697, 2287, 2354, 2637, 2759], 'μg': [1698], 'linearized': [1704], 'NotI': [1706], 'transfected': [1709], 'electroporation': [1711], '129': [1713], 'SvEviTL1': [1714], 'embryonic': [1715, 1798, 3367], 'stem': [1716, 1799, 3368], 'cells.': [1717, 3806, 3831], 'After': [1718, 2019], 'selection': [1719], 'neomycin-containing': [1721], 'medium': [1722, 3135], 'G418,': [1723], 'surviving': [1724], 'colonies': [1725], 'expanded.': [1727], 'performed': [1731, 2136, 2891], 'identify': [1733, 1828], 'clones': [1734, 1786], 'undergone': [1737], 'homologous': [1738], 'recombination.': [1739], 'primer': [1744, 1832, 3401], 'pairs': [1745, 1833], 'LRATSA6': [1746, 1750], 'Neo1.': [1748], 'Primer': [1749, 1766], 'outside': [1753], '80': [1757], 'bp': [1758, 1847, 3298], 'LRATSA1,': [1761], '5′-AAAGAATCAATAGGACAAAGAACTGG-3′.': [1765], 'Neo1': [1767, 3418], '5′-promoter': [1772], 'region': [1773, 3256, 3818], '5′-TGCGAGGCCAGAGGCCACTTGTGTAGC-3′.': [1783], 'positive': [1785], '1.4-kb': [1792], 'fragment.': [1794, 2043], 'correctly': [1796, 3365], 'lines': [1801, 3370], 'microinjected': [1803, 3372], 'C57BL/6J': [1805, 1896, 3374], 'blastocysts.': [1806, 3375], 'chimeric': [1808, 3363], 'generated,': [1811], 'they': [1813, 3703], 'gave': [1814], 'germ': [1815, 3380], 'line': [1816, 3381], 'transmission': [1817, 3050, 3382], 'gene.': [1822], 'Genotyping': [1823], 'Mice—To': [1827], 'wild-type': [1830, 3395], 'allele,': [1831], 'LRATSA1/LRATWT1': [1834], '(1.4-kb': [1835], 'fragment)': [1836, 1840], 'LRAT1S/LRATWT1': [1838], '(300-bp': [1839], 'used.': [1842], 'LRATWT1': [1843, 3406], '44': [1846], 'downstream': [1848, 1956], 'LRATSA2,': [1850], '5′-AAGTGCTGGGCATGGTGACTTGTG-3′.': [1854], 'LRAT1S': [1861, 3404, 3416], '(5′-TCCAGTTCCAGACTCTTTCCACCCAC-3′)': [1862], 'Neo-1': [1864], '(370-bp': [1865], 'fragment).': [1866], 'conditions': [1869, 2882], '94': [1871], '°C': [1872, 1877, 1882, 3083], '30': [1874, 1879, 1888], 's;': [1875, 1880, 1885], '72': [1881], '120': [1884], 'total': [1886], 'cycles.': [1889], 'outbred': [1893], 'strain.': [1897], 'Mouse': [1898, 2242, 3174, 3873], 'Anti-Lrat': [1899], 'Monoclonal': [1900], 'Antibody': [1901], 'Production—We': [1902], 'RNA': [1906, 1910], 'MicroAqueous': [1909], 'Isolation': [1911], 'Kit': [1912], '(Ambion).': [1913], 'Hotstart': [1919], 'Turbo': [1920], 'Pfu': [1921], 'Polymerase': [1922], '(Stratagene)': [1923], '5′-GCTCACCTCGTACAGAACAGTTGC-3′': [1927], '5′-ACATACACGTTGACCTGTGGACTG-3′.': [1929], 'corresponding': [1934, 4036], 'Gln89–Glu179': [1938], '5′-CATATGCAGAAGGTGGTCTCCAACAAGCGT-3′': [1951], '5′-GGATCCTCACTCAGCCTGTGGACTGATCCGAGA-3′': [1953], 'His6': [1959], 'tag': [1960, 3249], 'between': [1961, 2769, 3488, 3625, 3643, 3681, 3719, 4298], 'NdeI': [1963], 'BamHI': [1965], 'sites': [1966], 'inducible': [1969], 'bacterial': [1970], 'pET15b': [1973], '(Invitrogen).': [1974], 'plasmid': [1976], 'transformed': [1978], 'BL-21RP': [1980], '(Stratagene),': [1982], 'induced': [1986], 'isopropyl-1-thio-β-d-galactopyranoside.': [1988], 'His6-tagged': [1990], '(10': [1997, 2914], 'kDa)': [1998, 3453], 'purified': [2000, 2012, 2045], 'nickel-nitrilotriacetic': [2002], 'acid': [2003], 'affinity': [2004], 'chromatography': [2005], 'manufacturer’s': [2008], 'protocol': [2009], '(Qiagen).': [2010], 'examined': [2015, 2028, 2778, 2858], 'gel': [2017], 'electrophoresis.': [2018], 'in-gel': [2020], 'trypsin': [2021], 'digestion,': [2022], 'eluted': [2024], 'tryptic': [2025], 'peptides': [2026], 'microsequencing': [2030], 'chromatography-mass': [2033], 'spectrometry': [2034], 'verify': [2036], 'identity': [2038], 'immunize': [2050], 'before': [2054, 2368], '(23Haeseleer': [2055, 2994], 'Jang': [2057, 2465, 2499, 2539, 2996], 'G.F.': [2058, 2179, 2466, 2500, 2540, 2997], 'Imanishi': [2059, 2998], 'Driessen': [2061, 2191, 3000, 3950], 'C.A.': [2062, 2192, 3001, 3951, 3988], 'Matsumura': [2063, 3002], 'Nelson': [2065, 3004], 'P.S.': [2066, 3005], '277:': [2073, 2481, 2522, 3012], '45537-45546Abstract': [2074, 3013], '(154)': [2082, 3021], 'monoclonal': [2087], 'antibody': [2088, 2116], 'produced': [2090], 'established': [2092], 'methods': [2093], '(24Adamus': [2094], 'Zam': [2096], 'Z.S.': [2097], 'Emerson': [2098], 'S.S.': [2099], 'Hargrave': [2100], 'Vitro': [2103], 'Cell.': [2104, 4014], 'Dev.': [2105], '1989;': [2107], '25:': [2108], '1141-1146Crossref': [2109], '(3)': [2112], 'tested': [2118], 'specificity': [2121], 'immunocytochemical': [2123], 'testing': [2124, 2679], 'retinas.': [2131], 'Rhodopsin': [2132, 2273], 'Measurements—All': [2133], '(25Van': [2144, 2422, 2821], 'Hooser': [2145, 2181, 2214, 2423, 2457, 2506, 2537, 2822, 3948, 3973, 4001], 'J.P.': [2146, 2182, 2215, 2424, 2458, 2507, 2538, 2823, 3949, 3974, 4002], 'Aleman': [2147, 2425, 2824], 'T.S.': [2148, 2426, 2825], 'He': [2149, 2187, 2427, 2467, 2826], 'Y.G.': [2150, 2188, 2428, 2468, 2827], 'Cideciyan': [2151, 2429, 2828], 'A.V.': [2152, 2430, 2829], 'Pittler': [2155, 2433, 2832], 'S.J.': [2156, 2434, 2833], 'E.M.': [2158, 2436, 2835], 'Jacobson': [2159, 2437, 2836], 'S.G.': [2160, 2438, 2837], 'Proc.': [2163, 2441, 2840], 'Natl.': [2164, 2442, 2841], 'Acad.': [2165, 2443, 2842], 'U.': [2167, 2445, 2844], '97:': [2171, 2449, 2848], '8623-8628Crossref': [2172, 2450, 2849], '(223)': [2175, 2453, 2852], '26Jang': [2178], 'Van': [2180, 2213, 2505, 2536, 3947, 3972, 3997, 4000], 'McBee': [2185], 'Janssen': [2189, 3954, 3995, 4011], 'J.J.': [2190, 3955, 4012], '276:': [2199, 2547], '32456-32465Abstract': [2200], '(55)': [2208], '27Palczewski': [2211], 'Garwin': [2216, 3970], 'G.G.': [2217, 3971], 'Liou': [2220], 'G.I.': [2221], 'Saari': [2222], '38:': [2226, 3980], '12012-12019Crossref': [2227], '(136)': [2230], 'eyes': [2236, 2243, 2257, 2415, 2715, 4062, 4074], 'per': [2239, 4302, 4307, 4312, 4317, 4322, 4327, 4354, 4360], 'measurement.': [2241], 'enucleated': [2245], 'rinsed': [2247], 'double-stilled': [2249], 'H2O.': [2250], 'lenses': [2252], 'removed,': [2254], 'cut': [2259, 2979], 'pieces': [2264], 'frozen': [2266], 'immediately': [2267], 'dry': [2270], 'ice/EtOH': [2271], 'bath.': [2272], 'extracted': [2275, 2341], '0.9': [2277], 'ml': [2278], '20': [2280, 2623, 2738], 'mm': [2281, 2288, 2292, 2638, 2645], 'BisTris': [2282], 'propane,': [2283], 'pH': [2284, 2641, 2955, 2974, 3068, 3100, 3113], '7.5,': [2285], 'containing': [2286, 2643, 3070], 'dodecyl-β-maltoside': [2289], '5': [2291, 2308, 2325, 2981, 3859, 4199], 'freshly': [2293], 'neutralized': [2294], 'NH2OH·HCl.': [2295], 'sample': [2297, 2317], 'homogenized': [2299], 'Dounce': [2302], 'tissue': [2303], 'homogenizer': [2304], 'shaken': [2306], 'min': [2309, 2326, 2355, 2760], 'room': [2311, 2328, 3075, 3119], 'temperature': [2312, 2329, 3076], '(Eppendorf': [2313, 2330], 'mixer': [2314], '5432).': [2315], 'centrifuged': [2320, 2349], '14,000': [2322], 'rpm': [2323, 2352], 'centrifuge': [2331], '5415C).': [2332], 'supernatant': [2334], 'collected,': [2336], 'pellet': [2339], 'one': [2342], 'time.': [2344], 'combined': [2346], 'supernatants': [2347], '50,000': [2351], '(Beckman': [2356], 'Optima': [2357], 'TLX': [2358], 'centrifuge/TLA100.3': [2359], 'fixed': [2360, 2937, 3055, 3104], 'angle': [2361], 'rotor),': [2362], 'absorption': [2364, 2387], 'spectra': [2365], 'recorded': [2367, 2675, 2879], '12-min': [2372], 'bleach': [2373], '(60-watt': [2374], 'incandescent': [2375], 'bulb).': [2376], 'concentration': [2378], 'determined': [2382, 3436, 4041], 'decrease': [2385, 4228], '500': [2389], 'nm': [2390, 2601], 'molar': [2393], 'extinction': [2394], 'coefficient': [2395], '∈': [2396], '=': [2397, 3612], '42,000': [2398], 'm-1': [2399], 'cm-1.': [2400], 'Retinoids—All': [2401], 'related': [2404], 'extraction,': [2406], 'derivatization,': [2407], 'separation': [2409], 'retinoids': [2411, 2562, 3525, 3886, 3898, 3905, 4127, 4162], 'dissected': [2413], 'carried': [2417, 2564], 'out': [2418, 2565], '28Van': [2456], 'Liang': [2459, 2508], 'Maeda': [2461, 2497], 'T.': [2462, 2498, 3946], 'Rieke': [2469], 'Fong': [2471], 'H.K.': [2472], 'Detwiler': [2473], 'P.B.': [2474], '19173-19182Abstract': [2482], '(133)': [2490], '29Kuksa': [2493], 'Bartl': [2495], 'Ritter': [2501], 'Heck': [2503], 'Filipek': [2510, 3952], 'Gelb': [2512], 'Hofmann': [2514], 'K.P.': [2515], '42315-42324Abstract': [2523], '(35)': [2531], '30McBee': [2534], '48483-48493Abstract': [2548], '(41)': [2556], 'All': [2559, 3897], 'reactions': [2560], 'involving': [2561], 'light.': [2569], 'Retinoids': [2570], 'separated': [2572], 'normal': [2574, 3508], 'phase': [2575], 'HPLC': [2576, 2605], '(Beckman,': [2577], 'Ultrasphere-Si,': [2578], '4.6': [2579], '×': [2580], '250': [2581], 'mm)': [2582], '10%': [2584], 'ethyl': [2585], 'acetate': [2586, 3158], '90%': [2588], 'hexane': [2589], 'flow': [2592], 'rate': [2593], '1.4': [2595, 2782], 'ml/min': [2596], 'detection': [2598], '325': [2600], 'HP1100': [2604], 'diode': [2608], 'array': [2609], 'detector': [2610], 'HP': [2612], 'Chemstation': [2613], 'A.03.03': [2614], 'software.': [2615], 'ERGs—Mice': [2616], 'anesthetized': [2618], 'intraperitoneal': [2620], 'injection': [2621], 'μl/g': [2624], 'body': [2625], 'weight': [2626], '6': [2628], 'mg/ml': [2629, 2633], 'ketamine': [2630], '0.44': [2632], 'xylazine': [2634], 'diluted': [2635, 2965], 'sodium': [2639, 2953, 2972, 3098, 3111], 'phosphate,': [2640, 2954, 2973, 3099, 3112], '7.2,': [2642], '100': [2644, 4308, 4318, 4328, 4361], 'NaCl.': [2646], 'pupils': [2648], 'dilated': [2650], '1%': [2652, 3106], 'tropicamide.': [2653], 'contact': [2655], 'lens': [2656], 'electrode': [2657], 'placed': [2659, 2667, 2698], 'ground': [2664], 'electrodes': [2665], 'ear': [2670], 'tail.': [2672], 'ERGs': [2673], 'universal': [2678], 'electrophysiologic': [2681], 'UTAS': [2683], 'E-3000': [2684], '(LKC': [2685], 'Technologies,': [2686], 'Inc.).': [2687], 'intensity': [2690, 2736, 2755, 2905], 'calibrated': [2692, 2926], 'computer-controlled.': [2694], 'Ganzfeld': [2701], 'chamber,': [2702], 'scotopic': [2704], 'flash': [2709, 2730], 'stimuli': [2710, 2718, 2896], 'both': [2714], 'simultaneously.': [2716], 'Flash': [2717], 'range': [2721], 'intensities': [2723], '(-3.7–2.8': [2724], 'log': [2725, 2783], 'cd·s·m-2),': [2726], 'white': [2728], 'duration': [2731], 'adjusted': [2733], 'according': [2734], '(from': [2737], 'μs': [2739], 'ms).': [2742], 'Three': [2743], 'five': [2745], 'recordings': [2746], 'made': [2748, 2923], '>10-s': [2750], 'intervals,': [2751, 2756], 'higher': [2754, 3812], 'intervals': [2757], 'indicated.': [2763], 'There': [2764], 'significant': [2767, 3641], 'differences': [2768, 3718], 'first': [2771], 'fourth': [2773], 'flashes.': [2774], 'Light-adapted': [2775], 'bleaching': [2780], 'cd·m-2': [2784], '15': [2786], 'min.': [2787], 'eight': [2791], 'recording': [2796], 'each': [2798], 'point': [2799], 'conditions.': [2802], 'Leading': [2803], 'edges': [2804], 'ERG': [2807, 4371, 4382], 'fitted': [2810], 'phototransduction': [2816], 'activation': [2817], 'results': [2856, 4157, 4290], 'one-way': [2861], 'ANOVA': [2862], 'test.': [2863], 'Pupillometry—Mice': [2864], 'dark-adapted': [2866], 'least': [2869], 'h': [2871, 3079, 3117], 'prior': [2872, 3164], 'recordings.': [2874], 'Pupillary': [2875], 'infrared': [2881], 'CCD': [2885], 'video': [2886, 2893], 'camera;': [2887], 'data': [2888], 'pupillometry.': [2894], 'Light': [2895, 2931], 'provided': [2898], 'halogen': [2901], 'source.': [2902], 'Wavelength': [2903], 'manipulated': [2907], 'neutral': [2909], 'density': [2910], 'narrow': [2912], 'bandwidth': [2913], 'nm)': [2915, 3151], 'interference': [2916, 3877], 'filters': [2917], '(Oriel).': [2918], 'Irradiance': [2919], 'measurements': [2920], '(watts/m2)': [2921], 'radiometer': [2927], '(Advanced': [2928], 'Photonics': [2929], 'International).': [2930], 'Microscopy—For': [2932], 'microscopy,': [2934], 'eyecups': [2935, 3053, 3091, 3122, 3140], '2%': [2939, 2941, 3071], 'glutaraldehyde,': [2940, 3061], 'paraformaldehyde': [2942, 3063], '18': [2944], 'h,': [2945], 'infiltrated': [2946], '20%': [2948, 2967], 'sucrose': [2949, 2968, 3072], '0.1': [2951, 2970, 3109], 'm': [2952, 2971, 3066, 3097, 3110], '7.4,': [2956, 3069], 'embedded': [2959, 3142], '33%': [2961], 'OCT': [2962], 'compound': [2963], '(Miles)': [2964], '7.4.': [2975], 'Thin': [2976], 'sections': [2977, 3149, 3835], 'μm': [2982], 'subjected': [2984], 'microscopy.': [2987], 'Immunocytochemistry—All': [2988], 'Sections': [3024], 'analyzed': [3026], 'episcopic': [3029], 'fluorescent': [3030], 'microscope': [3031], '(Nikon).': [3032], 'Digital': [3033], 'images': [3034, 3710], 'captured': [3036], 'digital': [3039], 'camera': [3040], '(Diagnostic': [3041], 'Instruments;': [3042], 'Sterling': [3043], 'Heights,': [3044], 'MI).': [3045], 'Transmission': [3046], 'Electron': [3047], 'Microscopy': [3048], '(EM)—For': [3049], 'EM,': [3051], 'primarily': [3056], 'immersion': [3058], '2.5%': [3060], '1.6%': [3062], '0.08': [3065], 'initially': [3073], '∼1': [3078], '4': [3082, 4081], 'remainder': [3086], '24': [3088], 'h.': [3089], 'washed': [3094], '0.13': [3096], '7.35,': [3101, 3114], 'secondarily': [3103], 'OsO4': [3107], 'temperature.': [3120], 'dehydrated': [3124], 'through': [3125], 'methanol': [3127], 'series': [3128], 'transitioned': [3130], 'epoxy': [3133], 'embedding': [3134], 'propylene': [3137], 'oxide.': [3138], 'sectioning': [3144], 'Eponate': [3146], '812.': [3147], 'Ultrathin': [3148], '(60–70': [3150], 'stained': [3153], 'aqueous': [3155], 'saturated': [3156], 'uranium': [3157], 'Reynold’s': [3160], 'formula': [3161], 'lead': [3162], 'citrate': [3163], 'survey': [3166], 'micrography': [3168], 'Philips': [3171], 'CM10': [3172], 'EM.': [3173], 'Gene': [3176], 'Construct—The': [3179], 'appears': [3183], '(and': [3194], 'human)': [3195], 'genomes.': [3196], 'entire': [3198], 'can': [3203], 'found': [3205, 4211], 'NCBI': [3208], 'web': [3209], 'complement': [3213], '(18,757,074.18,766,035)': [3214], 'locus': [3216], 'NT_039234': [3217], '26,830,222': [3219], 'bp).': [3220, 3303], 'published': [3222], '(15Zolfaghari': [3227], '(accession': [3250], 'BY705162)': [3251], '250–267-nucleotide': [3254], '5′-untranslated': [3255], 'perfectly': [3258], 'matches': [3259], 'sequence.': [3263], 'Thus,': [3264], 'contrast': [3266], 'most': [3274, 4106], 'likely': [3275, 4107], 'untranslated': [3279], 'exons.': [3287], 'intervening': [3289], '∼6,040': [3297], 'length': [3300, 3592, 3754], '(human': [3301], '∼4,080': [3302], 'tags': [3307], 'colon,': [3316], 'spleen,': [3319], 'mammary': [3321], 'gland': [3322], '(e.g.': [3323], 'www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=33921).': [3325], 'vector,': [3330], 'cassette,': [3352], 'disabling': [3353], 'translation': [3354], '(Fig.': [3359, 3421, 3439, 3457, 3606, 3628, 3652, 3695, 3742, 3929, 4086, 4103, 4198], '1A).': [3360], 'generate': [3362], 'Heterozygous': [3376], 'outbreeding': [3387], '(Ingenious': [3389], 'Targeting,': [3390], 'Stony': [3391], 'Brooks,': [3392], 'NY).': [3393], 'allele': [3396], 'pair': [3402], '(diagnostic': [3407], '∼300': [3409], 'bp)': [3410, 3420], 'knockout': [3413], '(370': [3419], '1B).': [3422], 'abolished': [3428], 'eye': [3431, 3456, 4114], 'immunocytochemistry': [3438], '1C).': [3440], 'Immunoblotting': [3441], 'major': [3444, 3573], 'forms': [3446, 3477, 3490], '(28': [3449], 'kDa': [3450], '25': [3452], '1D)': [3458], '(data': [3463, 3665, 3725, 4046, 4144, 4240], 'not': [3464, 3492, 3666, 3715, 3726, 4047, 4145, 4241], 'shown)': [3465], 'could': [3470], 'arise': [3471], 'alternative': [3473], 'splicing/posttranslational': [3474], 'modifications.': [3475], 'Both': [3476], 'absent': [3479], 'mice.': [3482, 3785, 3793], 'reason': [3484], 'difference': [3487], 'investigated': [3493], 'further.': [3494], 'develop': [3498], 'similar': [3501, 4034, 4226], 'weight,': [3502], 'females': [3503], 'fertile': [3505], 'level,': [3509], 'males': [3511], 'frequently': [3515], 'infertile.': [3516], 'This': [3517, 4243], 'observation': [3518], 'consistent': [3520, 4250], 'reproductive': [3528], 'males,': [3531], 'observed': [3533, 3580, 4233], 'A-deprived': [3536], '(32Niederreither': [3538], 'Subbarayan': [3540], 'Dolle': [3542], 'Chambon': [3544], '21:': [3549], '444-448Crossref': [3550], '(875)': [3553], 'Histology': [3556], 'Ultrastructure': [3558], 'Retina': [3561], 'Mice—At': [3566], '6–8': [3567], 'weeks': [3568], 'age,': [3570], 'change': [3574], 'histology': [3576], 'reduction': [3589, 3763, 4244], 'ROS': [3594, 3689, 3697, 3751, 3846], 'when': [3598], 'compared': [3602, 3755], '2,': [3607], 'B,': [3610], 'n': [3611, 4296], '3).': [3613, 3696], 'nuclear': [3616], 'layer': [3617, 3676], 'inner': [3619], 'appeared': [3621], 'comparable': [3624, 3934, 4032, 4192], 'these': [3626, 3644], '2C).': [3629], 'Quantitative': [3630], 'calculations': [3631], 'thickness': [3634], 'different': [3636, 4286], 'showed': [3639, 3737, 4094], 'variation': [3642], 'genetic': [3646, 3939, 4287], 'backgrounds': [3647, 3940, 4288], 'within': [3648], 'error': [3651], '2D).': [3653], 'Retinas': [3654], 'indistinguishable': [3659], 'shown).': [3667, 3727, 4048, 4146, 4242], 'EM': [3668], 'gross': [3679], 'changes': [3680], 'exception': [3686], 'noted': [3691], 'thinner,': [3701], 'less': [3705, 3738], 'tightly': [3706], 'packed.': [3707], 'Higher': [3708, 3728], 'resolution': [3709, 3729], 'did': [3714], 'unveil': [3716], 'any': [3717, 3876], 'WT': [3723], 'synaptic': [3732, 3740, 3816, 3826, 3854], 'terminal': [3733, 3817, 3827], 'ribbons': [3741], '3,': [3743], 'C': [3744, 3807], 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