Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2166912270', 'doi': None, 'title': 'Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.', 'display_name': 'Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.', 'publication_year': 1999, 'publication_date': '1999-06-01', 'ids': {'openalex': 'https://openalex.org/W2166912270', 'mag': '2166912270', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10363963'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10363963', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023517416', 'display_name': 'Mary‐Ellen Taplin', 'orcid': 'https://orcid.org/0000-0002-3384-0300'}, 'institutions': [{'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mary-Ellen Taplin', 'raw_affiliation_strings': ['University of Massachusetts Cancer Center, Worcester 01655, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Massachusetts Cancer Center, Worcester 01655, USA', 'institution_ids': ['https://openalex.org/I166722992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043769628', 'display_name': 'Glenn J. Bubley', 'orcid': 'https://orcid.org/0000-0002-3062-643X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Glenn J. Bubley', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103736935', 'display_name': 'Yoo‐Joung Ko', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yoo-Joung Ko', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007578304', 'display_name': 'Eric J. Small', 'orcid': 'https://orcid.org/0000-0003-3191-6268'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Eric J. Small', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110112941', 'display_name': 'Melissa P. Upton', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Melissa P. Upton', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005611462', 'display_name': 'Barur Rajeshkumar', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Barur R. Rajeshkumar', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087350413', 'display_name': 'Steven P. Balk', 'orcid': 'https://orcid.org/0000-0002-4546-7371'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Steven P. Balk', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 22.668, 'has_fulltext': False, 'cited_by_count': 591, 'citation_normalized_percentile': {'value': 0.999925, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '59', 'issue': '11', 'first_page': '2511', 'last_page': '5'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11956', 'display_name': 'Sexual Differentiation and Disorders', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10124', 'display_name': 'Prostate Cancer Diagnosis and Treatment', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flutamide', 'display_name': 'Flutamide', 'score': 0.98930776}, {'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.8739655}], 'concepts': [{'id': 'https://openalex.org/C2778313021', 'wikidata': 'https://www.wikidata.org/wiki/Q418669', 'display_name': 'Flutamide', 'level': 5, 'score': 0.98930776}, {'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.8739655}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.8463392}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7373717}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.7299757}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.68305457}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.592941}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.55818444}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.48409832}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.47422978}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.42922515}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.38963747}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37401894}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34346002}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.33511007}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.2761408}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.22813535}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13570982}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11253989}], 'mesh': [{'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D019046', 'descriptor_name': 'Bone Marrow Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001706', 'descriptor_name': 'Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001853', 'descriptor_name': 'Bone Marrow', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001853', 'descriptor_name': 'Bone Marrow', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019046', 'descriptor_name': 'Bone Marrow Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D019046', 'descriptor_name': 'Bone Marrow Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003062', 'descriptor_name': 'Codon', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003062', 'descriptor_name': 'Codon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10363963', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1816722347', 'https://openalex.org/W1948383940', 'https://openalex.org/W1971184254', 'https://openalex.org/W2003985632', 'https://openalex.org/W2009402948', 'https://openalex.org/W2013614953', 'https://openalex.org/W2022635468', 'https://openalex.org/W2031454470', 'https://openalex.org/W2036744671', 'https://openalex.org/W2045828086', 'https://openalex.org/W2060181878', 'https://openalex.org/W2061686178', 'https://openalex.org/W2066570340', 'https://openalex.org/W2069791479', 'https://openalex.org/W2080966978', 'https://openalex.org/W2125957951', 'https://openalex.org/W2153354003', 'https://openalex.org/W2160064859', 'https://openalex.org/W2165631552', 'https://openalex.org/W2340534380', 'https://openalex.org/W2340799873', 'https://openalex.org/W61945152'], 'related_works': ['https://openalex.org/W70951107', 'https://openalex.org/W30124836', 'https://openalex.org/W2765785155', 'https://openalex.org/W2139920743', 'https://openalex.org/W2130806298', 'https://openalex.org/W2013301667', 'https://openalex.org/W1987903254', 'https://openalex.org/W1972416917', 'https://openalex.org/W1948383940', 'https://openalex.org/W1533984495'], 'abstract_inverted_index': {'The': [0], 'role': [1], 'of': [2, 24, 33], 'androgen': [3, 39, 67], 'receptor': [4], '(AR)': [5], 'mutations': [6, 78, 98], 'in': [7, 31, 100], 'androgen-independent': [8], 'prostate': [9], 'cancer': [10], '(PCa)': [11], 'was': [12, 70], 'determined': [13], 'by': [14, 53], 'examining': [15], 'AR': [16, 43, 60, 77, 86, 97], 'transcripts': [17], 'and': [18, 46], 'genes': [19], 'from': [20, 106], 'a': [21], 'large': [22], 'series': [23], 'bone': [25], 'marrow': [26], 'metastases.': [27], 'Mutations': [28], 'were': [29, 50], 'found': [30, 61], '5': [32], '16': [34], 'patients': [35, 64], 'who': [36], 'received': [37], 'combined': [38], 'blockade': [40], 'with': [41, 66, 75, 83], 'the': [42, 57, 90], 'antagonist': [44, 87], 'flutamide,': [45], 'these': [47], 'mutant': [48, 59, 91], 'ARs': [49], 'strongly': [51], 'stimulated': [52], 'flutamide.': [54], 'In': [55], 'contrast,': [56], 'single': [58], 'among': [62], '17': [63], 'treated': [65], 'ablation': [68], 'monotherapy': [69], 'not': [71], 'flutamide': [72, 107], 'stimulated.': [73], 'Patients': [74], 'flutamide-stimulated': [76], 'responded': [79], 'to': [80, 102], 'subsequent': [81], 'treatment': [82], 'bicalutamide,': [84], 'an': [85], 'that': [88, 96], 'blocks': [89], 'ARs.': [92], 'These': [93], 'findings': [94], 'demonstrate': [95], 'occur': [99], 'response': [101], 'strong': [103], 'selective': [104], 'pressure': [105], 'treatment.': [108]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2166912270', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 32}, {'year': 2015, 'cited_by_count': 40}, {'year': 2014, 'cited_by_count': 36}, {'year': 2013, 'cited_by_count': 25}, {'year': 2012, 'cited_by_count': 24}], 'updated_date': '2024-12-10T00:58:28.801065', 'created_date': '2016-06-24'}