Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2166805524', 'doi': 'https://doi.org/10.1111/j.2042-7158.1996.tb05936.x', 'title': 'Urinary Excretion Profile of Torasemide and its Diuretic Action in Dogs', 'display_name': 'Urinary Excretion Profile of Torasemide and its Diuretic Action in Dogs', 'publication_year': 1996, 'publication_date': '1996-04-01', 'ids': {'openalex': 'https://openalex.org/W2166805524', 'doi': 'https://doi.org/10.1111/j.2042-7158.1996.tb05936.x', 'mag': '2166805524', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8794986'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.1996.tb05936.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/48/4/375/37015510/j.2042-7158.1996.tb05936.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/jpp/article-pdf/48/4/375/37015510/j.2042-7158.1996.tb05936.x.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078390167', 'display_name': 'Yoshihisa Sogame', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshihisa Sogame', 'raw_affiliation_strings': ['Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081272816', 'display_name': 'Kanemichi Okano', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kanemichi Okano', 'raw_affiliation_strings': ['Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102020696', 'display_name': 'Kazutaka Hayashi', 'orcid': 'https://orcid.org/0000-0003-1673-2911'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazutaka Hayashi', 'raw_affiliation_strings': ['Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047434676', 'display_name': 'Takeshi Uchida', 'orcid': 'https://orcid.org/0000-0001-9270-8329'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takeshi Uchida', 'raw_affiliation_strings': ['Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024751821', 'display_name': 'Y. Tsuda', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshio Tsuda', 'raw_affiliation_strings': ['Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Central Research Laboratories, The Green Cross Corporation, 25-1, 2-chome, Shodai-Ohtani, Hirakata, Osaka, Japan', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2665, 'currency': 'GBP', 'value_usd': 3268, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.529208, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 80}, 'biblio': {'volume': '48', 'issue': '4', 'first_page': '375', 'last_page': '379'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Antibiotics Pharmacokinetics and Efficacy', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/loop-diuretic', 'display_name': 'Loop diuretic', 'score': 0.5159162}], 'concepts': [{'id': 'https://openalex.org/C2777955127', 'wikidata': 'https://www.wikidata.org/wiki/Q388801', 'display_name': 'Furosemide', 'level': 2, 'score': 0.9637314}, {'id': 'https://openalex.org/C2779918671', 'wikidata': 'https://www.wikidata.org/wiki/Q200656', 'display_name': 'Diuretic', 'level': 2, 'score': 0.9564558}, {'id': 'https://openalex.org/C10146269', 'wikidata': 'https://www.wikidata.org/wiki/Q185557', 'display_name': 'Excretion', 'level': 2, 'score': 0.7425404}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.60540974}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5476122}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.51596934}, {'id': 'https://openalex.org/C2781117629', 'wikidata': 'https://www.wikidata.org/wiki/Q424280', 'display_name': 'Loop diuretic', 'level': 3, 'score': 0.5159162}, {'id': 'https://openalex.org/C77411442', 'wikidata': 'https://www.wikidata.org/wiki/Q181100', 'display_name': 'Urinary system', 'level': 2, 'score': 0.4740127}, {'id': 'https://openalex.org/C2781231759', 'wikidata': 'https://www.wikidata.org/wiki/Q58184', 'display_name': 'Nephron', 'level': 3, 'score': 0.42751926}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.33298343}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24850553}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.16718596}], 'mesh': [{'descriptor_ui': 'D004232', 'descriptor_name': 'Diuretics', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000652', 'qualifier_name': 'urine', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004232', 'descriptor_name': 'Diuretics', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D004232', 'descriptor_name': 'Diuretics', 'qualifier_ui': 'Q000652', 'qualifier_name': 'urine', 'is_major_topic': False}, {'descriptor_ui': 'D004232', 'descriptor_name': 'Diuretics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005665', 'descriptor_name': 'Furosemide', 'qualifier_ui': 'Q000652', 'qualifier_name': 'urine', 'is_major_topic': False}, {'descriptor_ui': 'D005665', 'descriptor_name': 'Furosemide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005665', 'descriptor_name': 'Furosemide', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D005665', 'descriptor_name': 'Furosemide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007275', 'descriptor_name': 'Injections, Intravenous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009399', 'descriptor_name': 'Nephrons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009399', 'descriptor_name': 'Nephrons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077786', 'descriptor_name': 'Torsemide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.1996.tb05936.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/48/4/375/37015510/j.2042-7158.1996.tb05936.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8794986', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.1996.tb05936.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/48/4/375/37015510/j.2042-7158.1996.tb05936.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.69, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1569019847', 'https://openalex.org/W1964893573', 'https://openalex.org/W1984307730', 'https://openalex.org/W1992321602', 'https://openalex.org/W2052277746', 'https://openalex.org/W2083031323', 'https://openalex.org/W2091872000', 'https://openalex.org/W2092962821', 'https://openalex.org/W2114581048', 'https://openalex.org/W2161845208', 'https://openalex.org/W2241133726', 'https://openalex.org/W2252510564', 'https://openalex.org/W2262274601', 'https://openalex.org/W2283084239', 'https://openalex.org/W2403608797', 'https://openalex.org/W2408698508', 'https://openalex.org/W2410666136', 'https://openalex.org/W2411596211', 'https://openalex.org/W2469138218'], 'related_works': ['https://openalex.org/W4365136253', 'https://openalex.org/W2465675886', 'https://openalex.org/W2407715137', 'https://openalex.org/W2183468171', 'https://openalex.org/W2153370041', 'https://openalex.org/W2091872000', 'https://openalex.org/W2069711979', 'https://openalex.org/W2000835410', 'https://openalex.org/W1976497291', 'https://openalex.org/W1534820194'], 'abstract_inverted_index': {'The': [0, 23, 33, 47, 65, 83, 89], 'plasma': [1, 34, 84, 147], 'concentration': [2, 85], 'profile,': [3, 43], 'urinary': [4, 24, 41, 66, 119], 'excretion': [5, 25, 42, 53, 67, 120], 'rate': [6, 26, 68, 141], 'and': [7, 78, 122, 132], 'diuretic': [8, 48, 90, 110, 115, 128], 'response': [9, 91, 102, 111, 129], 'were': [10], 'studied': [11], 'in': [12, 126], 'anaesthetized': [13], 'dogs': [14], 'after': [15, 31, 57, 81], 'an': [16], 'intravenous': [17], 'administration': [18, 58], 'of': [19, 27, 69, 76, 113, 142], 'torasemide': [20, 70, 93, 131], 'or': [21], 'furosemide.': [22, 104], 'furosemide': [28, 77, 133], 'decreased': [29, 45, 79, 87], 'rapidly': [30, 56], 'administration.': [32, 82], 'concentration,': [35], 'which': [36, 50], 'is': [37], 'related': [38], 'to': [39, 92, 103, 148], 'the': [40, 52, 101, 109, 124, 127, 138, 143, 146, 149], 'also': [44, 86], 'rapidly.': [46], 'response,': [49], 'reflected': [51], 'rate,': [54, 121], 'occurred': [55, 94], 'but': [59, 97], 'lasted': [60, 98], 'for': [61], 'a': [62], 'short': [63], 'time.': [64], 'was': [71], 'much': [72], 'lower': [73], 'than': [74, 100], 'that': [75, 108, 123], 'slowly': [80, 96], 'slowly.': [88], 'more': [95], 'longer': [99], 'These': [105], 'results': [106], 'suggest': [107], 'profile': [112], 'either': [114], 'depends': [116], 'on': [117], 'their': [118], 'difference': [125], 'between': [130], 'may': [134], 'be': [135], 'explained': [136], 'by': [137], 'different': [139], 'transfer': [140], 'drugs': [144], 'from': [145], 'nephron.': [150]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2166805524', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T04:34:31.739964', 'created_date': '2016-06-24'}