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1022, 1093, 1103, 1124, 1132, 1214, 1245, 1267, 1297, 1317, 1353, 1410, 1432, 1465, 1495, 1532, 1642, 1674, 1718, 1744, 1770], 'patients': [19, 637, 735, 740, 779, 792, 798, 818, 998, 1386, 1533, 1558, 1643], 'with': [20, 595, 638, 736, 741, 762, 780, 793, 797, 799, 819, 836, 999, 1387, 1534, 1559, 1588, 1644], 'ALS:': [21, 639, 1612], 'a': [22, 589, 640, 701, 749, 1156, 1236], 'reflection': [23, 641], 'Th17': [25, 643, 678, 871, 1188], 'cells': [26, 644, 679, 872, 1153, 1263, 1381, 1695], 'activation?': [27], 'M.': [28, 30, 95, 225, 267, 269, 334, 464, 513], 'Rentzos,': [29, 268, 514], 'Rentzos': [31, 270, 604], 'Department': [32, 54, 118, 140, 162, 205, 248, 271, 293, 357, 379, 401, 444, 487, 515], 'Neurology,': [34, 56, 120, 142, 164, 207, 250, 273, 295, 359, 381, 403, 446, 489, 517], 'Aeginition': [35, 57, 78, 99, 121, 143, 165, 186, 208, 229, 251, 274, 296, 317, 338, 360, 382, 404, 425, 447, 468, 490, 518], 'Hospital,': [36, 58, 79, 100, 122, 144, 166, 187, 209, 230, 252, 275, 297, 318, 339, 361, 383, 405, 426, 448, 469, 491], 'Athens': [37, 59, 80, 101, 123, 145, 167, 188, 210, 231, 253, 276, 298, 319, 340, 362, 384, 406, 427, 449, 470, 492, 526], 'National': [38, 60, 81, 102, 124, 146, 168, 189, 211, 232, 254, 277, 299, 320, 341, 363, 385, 407, 428, 450, 471, 493], 'University,': [39, 61, 82, 103, 125, 147, 169, 190, 212, 233, 255, 278, 300, 321, 342, 364, 386, 408, 429, 451, 472, 494], 'School': [40, 62, 83, 104, 126, 148, 170, 191, 213, 234, 256, 279, 301, 322, 343, 365, 387, 409, 430, 452, 473, 495], 'Medicine,': [42, 64, 85, 106, 128, 150, 172, 193, 215, 236, 258, 281, 303, 324, 345, 367, 389, 411, 432, 454, 475, 497], 'Athens,': [43, 65, 86, 107, 129, 151, 173, 194, 216, 237, 259, 282, 304, 325, 346, 368, 390, 412, 433, 455, 476, 498], 'GreeceSearch': [44, 66, 87, 108, 130, 152, 174, 195, 217, 238, 260, 283, 305, 326, 347, 369, 391, 413, 434, 456, 477, 499], 'for': [45, 67, 88, 109, 131, 153, 175, 196, 218, 239, 261, 284, 306, 327, 348, 370, 392, 414, 435, 457, 478, 500, 968, 1211, 1294], 'more': [46, 68, 89, 110, 132, 154, 176, 197, 219, 240, 262, 285, 307, 328, 349, 371, 393, 415, 436, 458, 479, 501], 'papers': [47, 69, 90, 111, 133, 155, 177, 198, 220, 241, 263, 286, 308, 329, 350, 372, 394, 416, 437, 459, 480, 502], 'by': [48, 70, 91, 112, 134, 156, 178, 199, 221, 242, 264, 287, 309, 330, 351, 373, 395, 417, 438, 460, 481, 503, 682, 718, 1379], 'this': [49, 71, 92, 113, 135, 157, 179, 200, 222, 243, 265, 288, 310, 331, 352, 374, 396, 418, 439, 461, 482, 504, 593], 'authorA.': [50, 136, 180, 201, 289, 375, 419, 440], 'Rombos,': [51, 290], 'A.': [52, 138, 182, 203, 291, 377, 421, 442], 'Rombos': [53, 292, 606], 'authorC.': [72, 311], 'Nikolaou,': [73, 312], 'C.': [74, 313], 'Nikolaou': [75, 314, 608], 'Immunology': [76, 97, 184, 227, 315, 336, 423, 466], 'Lab,': [77, 98, 185, 228, 316, 337, 424, 467], 'authorM.': [93, 223, 332, 462], 'Zoga,': [94, 333], 'Zoga': [96, 335, 610], 'authorV.': [114, 353], 'Zouvelou,': [115, 354], 'V.': [116, 355], 'Zouvelou': [117, 356, 612], 'Dimitrakopoulos,': [137, 376], 'Dimitrakopoulos': [139, 378, 614], 'authorT.': [158, 397], 'Alexakis,': [159, 398], 'T.': [160, 399, 1205, 1404, 1693], 'Alexakis': [161, 400, 616], 'Tsoutsou,': [181, 420], 'Tsoutsou': [183, 422, 618], 'Samakovli,': [202, 441], 'Samakovli': [204, 443, 620], 'Michalopoulou,': [224, 463], 'Michalopoulou': [226, 465, 622], 'authorJ.': [244, 483], 'Evdokimidis,': [245, 484], 'J.': [246, 485, 625], 'Evdokimidis': [247, 486, 624], 'author': [266, 505], 'First': [506], 'published:': [507], '04': [508], 'March': [509], '2010': [510, 651, 657], 'https://doi.org/10.1111/j.1600-0404.2010.01333.xCitations:': [511], '72': [512], 'Hospital-Athens': [519], 'Medical': [520], 'School,': [521], '72-74': [522], 'Vas.': [523], 'Sophias': [524], 'Av,': [525], '11528,': [527], 'GreeceTel.:': [528], '+30': [529, 531], '2107289200Fax:': [530], '2107219860e-mail:': [532], '[email': [533], 'protected]': [534], 'Read': [535], 'the': [536, 574, 584, 705, 765, 767, 771, 775, 845, 863, 887, 930, 935, 994, 1023, 1074, 1095, 1100, 1130, 1160, 1182, 1187, 1212, 1265, 1291, 1298, 1318, 1351, 1408, 1526, 1639, 1768], 'full': [537, 548], 'textAboutPDF': [538], 'ToolsRequest': [539], 'permissionExport': [540], 'citationAdd': [541], 'to': [542, 564, 587, 690, 699], 'favoritesTrack': [543], 'citation': [544], 'ShareShare': [545], 'Give': [546], 'accessShare': [547, 550], 'text': [549], 'full-text': [551, 566, 590], 'accessPlease': [552], 'review': [553], 'our': [554], 'Terms': [555, 578], 'Conditions': [557, 580], 'Use': [559], 'check': [561], 'box': [562], 'below': [563, 586], 'share': [565, 588], 'version': [567, 591], 'article.I': [569], 'have': [570], 'read': [571], 'accept': [573], 'Wiley': [575], 'Online': [576], 'Library': [577], 'UseShareable': [582], 'LinkUse': [583], 'link': [585], 'article': [594], 'your': [596], 'friends': [597], 'colleagues.': [599], 'Learn': [600], 'more.Copy': [601], 'URL': [602], 'Abstract': [603], 'M,': [605, 611, 623, 1199, 1203, 1259, 1456, 1609], 'A,': [607, 615, 619, 621, 1661], 'C,': [609, 1398], 'V,': [613], 'T,': [617, 1039, 1043, 1570, 1606, 1709], 'activation?Acta': [645], 'Neurol': [646, 1082, 1249, 1479, 1504, 1598, 1702, 1775], 'Scand:': [647], '2010:': [648], '122:': [649], '425–429.©': [650], 'The': [652, 1121, 1234], 'Authors': [653], 'Journal': [654], 'compilation': [655], '©': [656], 'Blackwell': [658], 'Munksgaard.': [659], 'Background': [660], '–': [661, 715, 783, 852], 'There': [662], 'is': [663, 1290], 'evidence': [664], 'that': [665, 856, 1242], 'immunological': [666, 1584], 'factors': [667], 'may': [668, 859], 'involved': [669, 861], 'pathogenetic': [671, 864], 'mechanisms': [672, 865], 'amyotrophic': [674, 914, 940, 969, 1000, 1027, 1049, 1078, 1215, 1500, 1535, 1560, 1581, 1645, 1697, 1720, 1771], 'lateral': [675, 915, 941, 970, 1001, 1028, 1050, 1079, 1216, 1501, 1561, 1582, 1646, 1698, 1721, 1772], 'sclerosis': [676, 1051, 1684], '(ALS).': [677], 'characterized': [681], 'predominant': [683], 'production': [684, 1378, 1409], 'IL-17': [686, 730, 752, 784, 809, 829, 1345, 1411], 'suggested': [689], 'be': [691, 860], 'crucial': [692], 'destructive': [694], 'autoimmunity.': [695, 1270], 'Interleukin-23': [696, 1286], '(IL-23)': [697], 'appears': [698], 'play': [700], 'supporting': [702], 'role': [703, 936, 1349], 'continued': [706], 'stimulation': [707], 'survival': [709], 'Th17.': [711], 'Patients': [712], 'methods': [714], 'We': [716], 'measured': [717], 'enzyme-like': [719], 'immunosorbent': [720], 'assay': [721], '(ELISA)': [722], '(CSF)': [727], 'levels': [728, 758, 788, 813, 832, 1673], 'IL-23': [732, 754, 786, 811, 831, 1319, 1373], '22': [734, 1454], 'ALS': [737, 794, 820, 849, 1238], '19': [739, 1363], 'other': [742], 'non-inflammatory': [743], 'neurological': [744], 'disorders': [745], '(NIND)': [746], 'studied': [747], 'as': [748, 795, 867], 'control': [750], 'group.': [751], 'CSF': [757, 812], 'were': [759, 789, 814, 833], 'also': [760, 815], 'correlated': [761, 835], 'duration': [763], 'disease,': [766], 'disability': [768, 839], 'level': [769], 'clinical': [772, 842], 'subtype': [773, 843], 'disease': [776, 837, 846], 'onset': [777, 847], 'ALS.': [781, 875, 1475, 1750], 'Results': [782], 'higher': [790], 'compared': [796], 'NIND': [800], '(P': [801, 821], '=': [802, 806, 822, 826], '0.015': [803], 'P': [805, 825], '0.002': [807], 'respectively).': [808, 828], 'increased': [816], '0.0006': [823], '0.000001': [827], 'not': [834, 1636], 'duration,': [838], 'scale': [840, 1241], 'or': [841], 'patients.': [850, 1685], 'Conclusions': [851], 'Our': [853], 'findings': [854], 'suggest': [855], 'these': [857], 'molecules': [858], 'acting': [866], 'potential': [868], 'markers': [869], 'activation': [873, 1384], 'References': [876], '1': [877, 1164, 1438, 1554], 'Agar': [878], 'J,': [879, 1068, 1227, 1281, 1488, 1546], 'Durham': [880], 'H.': [881], 'Relevance': [882], 'oxidative': [884], 'injury': [885], 'pathogenesis': [888], 'motor': [890, 1472], 'neuron': [891], 'diseases.': [892, 1596], 'Amyotroph': [893, 1218, 1620, 1648], 'Lateral': [894, 1219, 1621, 1649], 'Scler': [895, 1220, 1622, 1650], 'Other': [896, 1651], 'Motor': [897, 1652], 'Neuron': [898, 1653], 'Disord': [899, 1654], '2003;': [900, 1301], '4:': [901], '232–': [902], '42.': [903], '2': [904, 1166], 'Menzies': [905], 'FM,': [906], 'Ince': [907], 'PG,': [908], 'Shaw': [909, 926], 'PJ.': [910, 927], 'Mitochondrial': [911], 'involvement': [912], 'sclerosis.': [916, 942, 971, 1002, 1029, 1080, 1217, 1389, 1502, 1537, 1562, 1647, 1699, 1722, 1773], 'Neurochem': [917], 'Int': [918], '2002;': [919, 945, 975, 1564, 1687], '40:': [920], '543–': [921], '51.': [922], '3': [923], 'Heath': [924], 'PR,': [925, 1178], 'Update': [928], 'on': [929, 1471], 'glutamatergic': [931], 'neurotransmitter': [932], 'system': [933, 1595], 'excitotoxicity': [938], 'Muscle': [943], 'Nerve': [944], '26:': [946], '438–': [947], '58.': [948], '4': [949], 'Rakhit': [950], 'R,': [951, 1201], 'Cunningham': [952], 'P,': [953], 'Furtos-Matei': [954], 'A': [955, 1090, 1737, 1740], 'et': [956, 1148, 1232, 1284, 1312, 1343, 1370, 1461, 1491, 1517, 1575, 1666, 1714, 1738], 'al.': [957, 1233, 1285, 1313, 1344, 1371, 1462, 1492, 1518, 1576, 1667, 1715, 1739], 'Oxidation-induced': [958], 'misfolding': [959], 'aggregation': [961], 'superoxide': [963], 'dismutase': [964], 'its': [966, 1468], 'implications': [967], 'J': [972, 1058, 1248, 1330, 1357, 1390, 1415, 1447, 1476, 1503, 1597, 1701, 1725], 'Biol': [973], 'Chem': [974], '277:': [976], '47551–': [977], '6.': [978, 1086, 1626, 1706], '5': [979], 'Troost': [980, 1010], 'D,': [981, 1011], 'Van': [982, 1012], 'Den': [983, 1013], 'Oord': [984, 1014], 'JJ,': [985, 1015], 'De': [986], 'Jong': [987, 1018], 'JM,': [988], 'Swaab': [989], 'DF.': [990], 'Lymphocytic': [991, 1071], 'infiltration': [992], 'spinal': [995, 1054, 1075, 1527], 'cord': [996, 1055, 1076], 'Clin': [1003], 'Neuropathol': [1004, 1030, 1477], '1989;': [1005], '8:': [1006, 1274], '289–': [1007], '94.': [1008], 'Vianney': [1016], 'de': [1017], 'JM.': [1019], 'Immunohistochemical': [1020], 'characterization': [1021], 'inflammatory': [1024, 1589, 1592], 'infiltrate': [1025], 'Appl': [1031], 'Neurobiol': [1032, 1538], '1990;': [1033], '16:': [1034], '401–': [1035], '10.': [1036], '7': [1037], 'Kawamata': [1038], 'Akiyama': [1040], 'H,': [1041, 1458, 1572, 1760], 'Yamada': [1042], 'McGeer': [1044], 'PL.': [1045], 'Immunologic': [1046], 'reactions': [1047], 'brain': [1052], 'tissue.': [1056], 'Am': [1057], 'Pathol': [1059], '1992;': [1060], '140:': [1061], '691–': [1062], '707.': [1063], '8': [1064], 'Engelhardt': [1065], 'JI,': [1066], 'Tajti': [1067], 'Appel': [1069], 'SH.': [1070], 'infiltrates': [1072], 'Arch': [1081], '1993;': [1083], '50:': [1084], '30–': [1085], '9': [1087], 'Steinman': [1088], 'L.': [1089, 1429], 'brief': [1091], 'history': [1092], 'TH.17,': [1094], 'first': [1096], 'major': [1097], 'revision': [1098], 'TH.1/TH.2': [1101], 'hypothesis': [1102], 'T': [1104, 1133, 1152, 1161, 1342, 1445, 1460, 1519, 1694], 'cell-mediated': [1105], 'tissue': [1106], 'damage.': [1107], 'Nat': [1108, 1168, 1271], 'Med': [1109, 1726], '2007;': [1110, 1273, 1727], '13:': [1111], '139–': [1112], '45.': [1113], '10': [1114], 'Trinchieri': [1115], 'G,': [1116, 1367, 1663], 'Pflanz': [1117], 'S,': [1118, 1340, 1427, 1486, 1735], 'Kastelein': [1119], 'RA.': [1120], 'IL-12': [1122], 'family': [1123], 'heterodimeric': [1125], 'cytokines:': [1126], 'new': [1127], 'players': [1128], 'regulation': [1131], 'cell': [1134, 1520], 'responses.': [1135], 'Immunity': [1136], '2005;': [1137, 1170], '19:': [1138], '641–': [1139], '4.': [1140], '11': [1141], 'Harrington': [1142, 1175], 'LE,': [1143, 1176], 'Hatton': [1144], 'RD,': [1145], 'Mangan': [1146, 1177], 'PR': [1147], 'al.Interleukin-17-producing': [1149], 'CD4+': [1150], 'effect': [1151], 'develop': [1154], 'via': [1155], 'lineage': [1157], 'distinct': [1158], 'from': [1159], 'helper': [1162], 'type': [1163, 1437], 'lineages.': [1167], 'Immunol': [1169, 1192, 1272, 1331, 1358, 1416], '6:': [1171, 1541], '1123–': [1172], '32.': [1173, 1453], '12': [1174], 'Weaver': [1179], 'CT.': [1180], 'Expanding': [1181], 'effector': [1183], 'CD4': [1184], 'T-cell': [1185, 1434, 1618], 'repertoire:': [1186], 'lineage.': [1189], 'Curr': [1190, 1774], 'Opin': [1191], '2006;': [1193, 1359, 1480, 1623], '18:': [1194], '349–': [1195], '56.': [1196], '13': [1197], 'Brooks': [1198], 'Miller': [1200], 'Swash': [1202], 'Munsat': [1204], 'El': [1206], 'Escorial': [1207], 'revisited:': [1208], 'revised': [1209, 1237], 'criteria': [1210], 'diagnosis': [1213], '2000;': [1221, 1417], '1:': [1222], '293–': [1223], '9.': [1224, 1603, 1690], '14': [1225], 'Cedarbaum': [1226], 'Stambler': [1228], 'N,': [1229], 'Malta': [1230], 'E': [1231], 'ALSFRS-R:': [1235], 'functional': [1239], 'rating': [1240], 'incorporates': [1243], 'assessments': [1244], 'respiratory': [1246], 'function.': [1247], 'Sci': [1250, 1505, 1599], '1999;': [1251, 1540], '169:': [1252], '13–': [1253], '21.': [1254], '15': [1255], 'Bettelli': [1256], 'E,': [1257, 1514], 'Oukka': [1258], 'Kuchroo': [1260], 'VK.': [1261], 'T(H)-17': [1262], 'circle': [1266], 'immunity': [1268], '345–': [1275], '50.': [1276], '16': [1277], 'Cua': [1278], 'DJ,': [1279], 'Sherlock': [1280], 'Chen': [1282], 'Y': [1283], 'rather': [1287], 'than': [1288], 'interleukin-12': [1289], 'critical': [1292], 'cytokine': [1293, 1613], 'autoimmune': [1295, 1355], 'inflammation': [1296], 'brain.': [1299], 'Nature': [1300], '421:': [1302], '744–': [1303], '8.': [1304], '17': [1305, 1441], 'Wiekowski': [1306], 'MT,': [1307], 'Leach': [1308], 'MW,': [1309], 'Evans': [1310], 'EW': [1311], 'Ubiquitous': [1314], 'transgenic': [1315], 'expression': [1316, 1443], 'subunit': [1320], 'p19': [1321], 'induces': [1322, 1439], 'multiorgan': [1323], 'inflammation,': [1324], 'runting,': [1325], 'infertility,': [1326], 'premature': [1328], 'death.': [1329], '2001;': [1332, 1506], '166:': [1333], '7563–': [1334], '70.': [1335], '18': [1336], 'Komiyama': [1337], 'Y,': [1338], 'Nakae': [1339], 'Matsuki': [1341], 'plays': [1346], 'an': [1347], 'important': [1348], 'development': [1352], 'experimental': [1354], 'encephalomyelitis.': [1356], '177:': [1360], '566–': [1361], '73.': [1362], 'Dembinsky': [1364], 'AV,': [1365], 'Murugaiyan': [1366], 'Hafler': [1368], 'DA': [1369], 'Increased': [1372, 1493], 'secretion': [1374], 'altered': [1376], 'chemokine': [1377], 'dendritic': [1380], 'upon': [1382], 'CD46': [1383], 'multiple': [1388, 1536, 1683], 'Neuroimmunol': [1391], '2008;': [1392, 1703], '195:': [1393], '140–': [1394], '5.': [1395], '20': [1396], 'Infante-Duarte': [1397], 'Horton': [1399], 'HF,': [1400], 'Byrne': [1401], 'MC,': [1402], 'Kamradt': [1403], 'Microbial': [1405], 'lipopeptides': [1406], 'induce': [1407], 'Th': [1413], 'cells.': [1414, 1446], '165:': [1418], '6107–': [1419], '15.': [1420], '21': [1421], 'Dodon': [1422], 'MD,': [1423], 'Li': [1424], 'Z,': [1425, 1548], 'Hamaia': [1426], 'Gazzolo': [1428], 'Tax': [1430], 'protein': [1431, 1672], 'human': [1433], 'leukaemia': [1435], 'virus': [1436], 'interleukin': [1440], 'gene': [1442, 1523, 1746], 'Gen': [1448], 'Virol': [1449], '2004;': [1450, 1655], '85:': [1451], '1921–': [1452], 'Tanaka': [1455], 'Kikuchi': [1457], 'Ishizu': [1459], 'Intrathecal': [1463], 'upregulation': [1464], 'G-CSF': [1466], 'neuroprotective': [1469], 'actions': [1470], 'neurons': [1473], 'Exp': [1478], '65:': [1481], '816–': [1482], '25.': [1483], '23': [1484], 'Ono': [1485], 'Hu': [1487], 'Shimizu': [1489], 'N': [1490, 1723], 'interleukin-6': [1494, 1579], 'skin': [1496], '187:': [1507], '27–': [1508], '34.': [1509], '24': [1510], 'Panzara': [1511], 'MA,': [1512], 'Gussoni': [1513], 'Begovich': [1515], 'AB': [1516], 'receptor': [1521, 1680], 'BV': [1522], 'rearrangements': [1524], 'cords': [1528], 'Dis': [1539], '392–': [1542], '405.': [1543], '25': [1544], 'Ilzecka': [1545], 'Stelmasiak': [1547], 'Dobosz': [1549], 'B.': [1550], 'Transforming': [1551], 'growth': [1552], 'factor-beta': [1553], '(TGF-beta': [1555], '1)': [1556], 'Cytokine': [1563, 1686], '20:': [1565, 1688], '239–': [1566], '43.': [1567], '26': [1568], 'Sekizawa': [1569], 'Openshaw': [1571], 'Obbo': [1573], 'K': [1574], 'Cerebrospinal': [1577, 1668], 'sclerosis:': [1583], 'parameter': [1585], 'comparison': [1587], 'non': [1591], 'central': [1593], 'nervous': [1594], '1998;': [1600], '154:': [1601], '194–': [1602], '27': [1604], 'Holmøy': [1605], 'Roos': [1607], 'Per': [1608], 'Kvale': [1610], 'E.': [1611], 'profile': [1614], 'clones.': [1619], '7:': [1624], '183–': [1625], '28': [1627], 'Ford': [1628], 'L,': [1629], 'Rowe': [1630], 'D.': [1631], 'Interleukin-12': [1632], 'interferon-gamma': [1634], 'detectable': [1637], '5:': [1656], '118–': [1657], '20.': [1658], '29': [1659], 'Vladić': [1660], 'Horvat': [1662], 'Vukadin': [1664], 'S': [1665], 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