Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2166623795', 'doi': 'https://doi.org/10.4049/jimmunol.179.4.2551', 'title': 'IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex', 'display_name': 'IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex', 'publication_year': 2007, 'publication_date': '2007-08-15', 'ids': {'openalex': 'https://openalex.org/W2166623795', 'doi': 'https://doi.org/10.4049/jimmunol.179.4.2551', 'mag': '2166623795', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17675517'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.179.4.2551', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/179/4/2551/1244956/zim01607002551.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/179/4/2551/1244956/zim01607002551.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002460450', 'display_name': 'Alissa Chackerian', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Alissa A. Chackerian', 'raw_affiliation_strings': ['Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304'], 'affiliations': [{'raw_affiliation_string': 'Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054632483', 'display_name': 'Elizabeth R. Oldham', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Elizabeth R. Oldham', 'raw_affiliation_strings': ['Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304'], 'affiliations': [{'raw_affiliation_string': 'Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103398224', 'display_name': 'Erin E. Murphy', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Erin E. Murphy', 'raw_affiliation_strings': ['Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304'], 'affiliations': [{'raw_affiliation_string': 'Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046207606', 'display_name': 'Jochen Schmitz', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jochen Schmitz', 'raw_affiliation_strings': ['Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304'], 'affiliations': [{'raw_affiliation_string': 'Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035377248', 'display_name': 'Stefan Pflanz', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Stefan Pflanz', 'raw_affiliation_strings': ['Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304'], 'affiliations': [{'raw_affiliation_string': 'Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103497871', 'display_name': 'Robert A. Kastelein', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Robert A. Kastelein', 'raw_affiliation_strings': ['Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304'], 'affiliations': [{'raw_affiliation_string': 'Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 10.666, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 486, 'citation_normalized_percentile': {'value': 0.999907, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '179', 'issue': '4', 'first_page': '2551', 'last_page': '2555'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12528', 'display_name': 'Innate Lymphoid Cells in Immunity', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12528', 'display_name': 'Innate Lymphoid Cells in Immunity', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12538', 'display_name': 'Diagnosis and Management of Eosinophilic Esophagitis', 'score': 0.9787, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/il-33', 'display_name': 'IL-33', 'score': 0.534068}], 'concepts': [{'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5227383}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44654232}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.39010048}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27838075}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14347121}], 'mesh': [{'descriptor_ui': 'D053577', 'descriptor_name': 'Interleukin-1 Receptor Accessory Protein', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008407', 'descriptor_name': 'Mast Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005799', 'descriptor_name': 'Genes, Dominant', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005799', 'descriptor_name': 'Genes, Dominant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053577', 'descriptor_name': 'Interleukin-1 Receptor Accessory Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053577', 'descriptor_name': 'Interleukin-1 Receptor Accessory Protein', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D000072179', 'descriptor_name': 'Interleukin-1 Receptor-Like 1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053582', 'descriptor_name': 'Interleukin-1alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053582', 'descriptor_name': 'Interleukin-1alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053582', 'descriptor_name': 'Interleukin-1alpha', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000067596', 'descriptor_name': 'Interleukin-33', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008407', 'descriptor_name': 'Mast Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008407', 'descriptor_name': 'Mast Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018123', 'descriptor_name': 'Receptors, Interleukin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.179.4.2551', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/179/4/2551/1244956/zim01607002551.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.324.6663', 'pdf_url': 'http://www.jimmunol.org/content/179/4/2551.full.pdf', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17675517', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.179.4.2551', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/179/4/2551/1244956/zim01607002551.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1966000361', 'https://openalex.org/W1973064016', 'https://openalex.org/W1989166339', 'https://openalex.org/W1996775001', 'https://openalex.org/W1998160288', 'https://openalex.org/W2012484718', 'https://openalex.org/W2040470785', 'https://openalex.org/W2050267061', 'https://openalex.org/W2051771323', 'https://openalex.org/W2068044260', 'https://openalex.org/W2078136106', 'https://openalex.org/W2084671075', 'https://openalex.org/W2107230539', 'https://openalex.org/W2108283718', 'https://openalex.org/W2116101489', 'https://openalex.org/W2117047064', 'https://openalex.org/W2120106075', 'https://openalex.org/W2120517163', 'https://openalex.org/W2147067763', 'https://openalex.org/W2150230181', 'https://openalex.org/W2157710399', 'https://openalex.org/W4247547356'], 'related_works': ['https://openalex.org/W657579294', 'https://openalex.org/W4387497383', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2527526854', 'https://openalex.org/W2062208111', 'https://openalex.org/W1986764834', 'https://openalex.org/W1976181487', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'Abstract': [0], 'IL-33': [1, 30, 50, 106], '(IL-1F11)': [2], 'is': [3, 66, 76], 'a': [4, 25, 36, 54, 61, 68], 'recently': [5], 'described': [6], 'member': [7, 69], 'of': [8, 12, 18, 24, 70, 95, 99], 'the': [9, 16, 71], 'IL-1': [10], 'family': [11], 'cytokines': [13], 'that': [14, 49, 65], 'stimulates': [15], 'generation': [17], 'cells,': [19], 'cytokines,': [20], 'and': [21, 41, 51, 83, 103, 105], 'Igs': [22], 'characteristic': [23], 'type': [26], '2': [27], 'immune': [28], 'response.': [29], 'mediates': [31], 'signal': [32, 85], 'transduction': [33, 86], 'through': [34], 'ST2,': [35], 'receptor': [37, 63], 'expressed': [38], 'on': [39], 'Th2': [40], 'mast': [42], 'cells.': [43], 'In': [44], 'this': [45, 96], 'study,': [46], 'we': [47], 'demonstrate': [48], 'ST2': [52], 'form': [53], 'complex': [55], 'with': [56], 'IL-1R': [57, 72], 'accessory': [58], 'protein': [59], '(IL-1RAcP),': [60], 'signaling': [62], 'subunit': [64], 'also': [67], 'complex.': [73], 'Additionally,': [74], 'IL-1RAcP': [75, 100], 'required': [77], 'for': [78], 'IL-33-induced': [79], 'in': [80], 'vivo': [81], 'effects,': [82], 'IL-33-mediated': [84], 'can': [87], 'be': [88], 'inhibited': [89], 'by': [90, 101], 'dominant-negative': [91], 'IL-1RAcP.': [92], 'The': [93], 'implications': [94], 'shared': [97], 'usage': [98], 'IL-1(α': [102], 'β)': [104], 'are': [107], 'discussed.': [108]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2166623795', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 20}, {'year': 2018, 'cited_by_count': 31}, {'year': 2017, 'cited_by_count': 30}, {'year': 2016, 'cited_by_count': 35}, {'year': 2015, 'cited_by_count': 45}, {'year': 2014, 'cited_by_count': 31}, {'year': 2013, 'cited_by_count': 43}, {'year': 2012, 'cited_by_count': 41}], 'updated_date': '2024-09-16T11:36:52.965876', 'created_date': '2016-06-24'}