Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2166494447', 'doi': 'https://doi.org/10.1101/gad.250985.114', 'title': 'Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33', 'display_name': 'Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33', 'publication_year': 2014, 'publication_date': '2014-10-09', 'ids': {'openalex': 'https://openalex.org/W2166494447', 'doi': 'https://doi.org/10.1101/gad.250985.114', 'mag': '2166494447', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25301781', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4215183'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.250985.114', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1101/gad.250985.114', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043709578', 'display_name': 'Lars Schönemann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I68956291', 'display_name': 'Martin Luther University Halle-Wittenberg', 'ror': 'https://ror.org/05gqaka33', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I68956291']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lars Schönemann', 'raw_affiliation_strings': ['1Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06099 Halle, Germany'], 'affiliations': [{'raw_affiliation_string': '1Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06099 Halle, Germany', 'institution_ids': ['https://openalex.org/I68956291']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037075303', 'display_name': 'Uwe Kühn', 'orcid': 'https://orcid.org/0000-0002-8495-1414'}, 'institutions': [{'id': 'https://openalex.org/I68956291', 'display_name': 'Martin Luther University Halle-Wittenberg', 'ror': 'https://ror.org/05gqaka33', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I68956291']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Uwe Kühn', 'raw_affiliation_strings': ['1Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06099 Halle, Germany'], 'affiliations': [{'raw_affiliation_string': '1Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06099 Halle, Germany', 'institution_ids': ['https://openalex.org/I68956291']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046091216', 'display_name': 'Georges Martín', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Georges Martin', 'raw_affiliation_strings': ['2Computational and Systems Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': '2Computational and Systems Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102815745', 'display_name': 'Peter Schäfer', 'orcid': 'https://orcid.org/0000-0002-3880-0850'}, 'institutions': [{'id': 'https://openalex.org/I68956291', 'display_name': 'Martin Luther University Halle-Wittenberg', 'ror': 'https://ror.org/05gqaka33', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I68956291']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Peter Schäfer', 'raw_affiliation_strings': ['1Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06099 Halle, Germany'], 'affiliations': [{'raw_affiliation_string': '1Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06099 Halle, Germany', 'institution_ids': ['https://openalex.org/I68956291']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046060796', 'display_name': 'Andreas Gruber', 'orcid': 'https://orcid.org/0000-0003-1219-4239'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Andreas R. Gruber', 'raw_affiliation_strings': ['2Computational and Systems Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': '2Computational and Systems Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034442754', 'display_name': 'Walter Keller', 'orcid': 'https://orcid.org/0000-0002-2261-958X'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Walter Keller', 'raw_affiliation_strings': ['2Computational and Systems Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': '2Computational and Systems Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018588101', 'display_name': 'Mihaela Zavolan', 'orcid': 'https://orcid.org/0000-0002-8832-2041'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Mihaela Zavolan', 'raw_affiliation_strings': ['2Computational and Systems Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': '2Computational and Systems Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041558179', 'display_name': 'Elmar Wahle', 'orcid': 'https://orcid.org/0000-0003-2504-0677'}, 'institutions': [{'id': 'https://openalex.org/I68956291', 'display_name': 'Martin Luther University Halle-Wittenberg', 'ror': 'https://ror.org/05gqaka33', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I68956291']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Elmar Wahle', 'raw_affiliation_strings': ['1Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06099 Halle, Germany'], 'affiliations': [{'raw_affiliation_string': '1Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06099 Halle, Germany', 'institution_ids': ['https://openalex.org/I68956291']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.394, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 202, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '28', 'issue': '21', 'first_page': '2381', 'last_page': '2393'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cleavage-stimulation-factor', 'display_name': 'Cleavage stimulation factor', 'score': 0.6019551}, {'id': 'https://openalex.org/keywords/post-transcriptional-modification', 'display_name': 'Post-transcriptional modification', 'score': 0.5899586}, {'id': 'https://openalex.org/keywords/cleavage', 'display_name': 'Cleavage (geology)', 'score': 0.449231}], 'concepts': [{'id': 'https://openalex.org/C62531158', 'wikidata': 'https://www.wikidata.org/wiki/Q21100335', 'display_name': 'Cleavage and polyadenylation specificity factor', 'level': 5, 'score': 0.99055064}, {'id': 'https://openalex.org/C142575336', 'wikidata': 'https://www.wikidata.org/wiki/Q412148', 'display_name': 'Polyadenylation', 'level': 4, 'score': 0.97039616}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.774772}, {'id': 'https://openalex.org/C133672593', 'wikidata': 'https://www.wikidata.org/wiki/Q5130990', 'display_name': 'Cleavage factor', 'level': 4, 'score': 0.70263904}, {'id': 'https://openalex.org/C67492840', 'wikidata': 'https://www.wikidata.org/wiki/Q22326127', 'display_name': 'Cleavage stimulation factor', 'level': 5, 'score': 0.6019551}, {'id': 'https://openalex.org/C22232683', 'wikidata': 'https://www.wikidata.org/wiki/Q417379', 'display_name': 'Post-transcriptional modification', 'level': 5, 'score': 0.5899586}, {'id': 'https://openalex.org/C41282012', 'wikidata': 'https://www.wikidata.org/wiki/Q3928341', 'display_name': 'RNA-binding protein', 'level': 4, 'score': 0.5306372}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5127593}, {'id': 'https://openalex.org/C175156509', 'wikidata': 'https://www.wikidata.org/wiki/Q1990218', 'display_name': 'Cleavage (geology)', 'level': 3, 'score': 0.449231}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.36481535}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26759487}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1358631}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C43369102', 'wikidata': 'https://www.wikidata.org/wiki/Q2307625', 'display_name': 'Fracture (geology)', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D039223', 'descriptor_name': 'Cleavage And Polyadenylation Specificity Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D026721', 'descriptor_name': "RNA 3' End Processing", 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D039223', 'descriptor_name': 'Cleavage And Polyadenylation Specificity Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D039223', 'descriptor_name': 'Cleavage And Polyadenylation Specificity Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026723', 'descriptor_name': 'Polyadenylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D026721', 'descriptor_name': "RNA 3' End Processing", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.250985.114', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4215183', 'pdf_url': 'https://europepmc.org/articles/pmc4215183?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215183', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://edoc.unibas.ch/34873/1/20141103171536_5457aa28ce76d.pdf', 'pdf_url': 'http://edoc.unibas.ch/34873/1/20141103171536_5457aa28ce76d.pdf', 'source': {'id': 'https://openalex.org/S4306401836', 'display_name': 'edoc (University of Basel)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1850255', 'host_organization_name': 'University of Basel', 'host_organization_lineage': ['https://openalex.org/I1850255'], 'host_organization_lineage_names': ['University of Basel'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://genesdev.cshlp.org/cgi/content/short/28/21/2381', 'pdf_url': 'http://genesdev.cshlp.org/content/28/21/2381.full.pdf', 'source': {'id': 'https://openalex.org/S128516502', 'display_name': 'Notes and Queries', 'issn_l': '0029-3970', 'issn': ['0029-3970', '1471-6941'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25301781', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.250985.114', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320879', 'funder_display_name': 'Deutsche Forschungsgemeinschaft', 'award_id': 'WA 548/15-1'}, {'funder': 'https://openalex.org/F4320320924', 'funder_display_name': 'Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung', 'award_id': '31003A-143977'}], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W117601042', 'https://openalex.org/W1489207129', 'https://openalex.org/W1545350340', 'https://openalex.org/W1579500886', 'https://openalex.org/W1883850860', 'https://openalex.org/W1967637890', 'https://openalex.org/W1972484052', 'https://openalex.org/W1975085160', 'https://openalex.org/W1979863623', 'https://openalex.org/W1984594593', 'https://openalex.org/W1985267020', 'https://openalex.org/W1991103421', 'https://openalex.org/W1991230146', 'https://openalex.org/W1995824852', 'https://openalex.org/W2001452204', 'https://openalex.org/W2003805923', 'https://openalex.org/W2004070918', 'https://openalex.org/W2005707003', 'https://openalex.org/W2006337626', 'https://openalex.org/W2010088308', 'https://openalex.org/W2014662954', 'https://openalex.org/W2019815305', 'https://openalex.org/W2020204531', 'https://openalex.org/W2026920658', 'https://openalex.org/W2032033331', 'https://openalex.org/W2035225194', 'https://openalex.org/W2043111511', 'https://openalex.org/W2053003053', 'https://openalex.org/W2055034539', 'https://openalex.org/W2058872954', 'https://openalex.org/W2062575193', 'https://openalex.org/W2071347544', 'https://openalex.org/W2079591756', 'https://openalex.org/W2084181602', 'https://openalex.org/W2087789109', 'https://openalex.org/W2092590107', 'https://openalex.org/W2093295511', 'https://openalex.org/W2097655931', 'https://openalex.org/W2097664345', 'https://openalex.org/W2097734332', 'https://openalex.org/W2105879579', 'https://openalex.org/W2106774938', 'https://openalex.org/W2107277218', 'https://openalex.org/W2107731897', 'https://openalex.org/W2114476704', 'https://openalex.org/W2122479069', 'https://openalex.org/W2127562368', 'https://openalex.org/W2131824470', 'https://openalex.org/W2150351594', 'https://openalex.org/W2153756898', 'https://openalex.org/W2155077792', 'https://openalex.org/W2159666069', 'https://openalex.org/W2162189448', 'https://openalex.org/W2163741321', 'https://openalex.org/W2164064395', 'https://openalex.org/W2166829841', 'https://openalex.org/W2172208515', 'https://openalex.org/W4238453787'], 'related_works': ['https://openalex.org/W4256073701', 'https://openalex.org/W4250186301', 'https://openalex.org/W4249449806', 'https://openalex.org/W4240987873', 'https://openalex.org/W2175402012', 'https://openalex.org/W2009700107', 'https://openalex.org/W1883850860', 'https://openalex.org/W1787193294', 'https://openalex.org/W1764884856', 'https://openalex.org/W1488258440'], 'abstract_inverted_index': {'Cleavage': [0], 'and': [1, 33, 35, 59, 63, 77, 92, 113, 121, 151], 'polyadenylation': [2, 23, 147], 'specificity': [3, 28], 'factor': [4], '(CPSF)': [5], 'is': [6, 82, 149], 'the': [7, 11, 22, 44, 125, 138, 146], 'central': [8], 'component': [9], 'of': [10, 43, 86, 106, 145], '3′': [12], 'processing': [13], 'machinery': [14], 'for': [15, 84], 'polyadenylated': [16], 'mRNAs': [17], 'in': [18, 29, 71, 120, 128, 143], 'metazoans:': [19], 'CPSF': [20, 68, 88, 140], 'recognizes': [21], 'signal': [24, 127, 148], 'AAUAAA,': [25], 'providing': [26], 'sequence': [27], 'both': [30], 'pre-mRNA': [31, 37], 'cleavage': [32], 'polyadenylation,': [34, 73], 'catalyzes': [36], 'cleavage.': [38], 'Here': [39], 'we': [40], 'show': [41], 'that': [42, 47, 117, 137], 'seven': [45], 'polypeptides': [46], 'have': [48], 'been': [49], 'proposed': [50], 'to': [51, 65, 89, 98, 124], 'constitute': [52], 'CPSF,': [53], 'only': [54], 'four': [55], '(CPSF160,': [56], 'CPSF30,': [57], 'hFip1,': [58], 'WDR33)': [60], 'are': [61, 79], 'necessary': [62], 'sufficient': [64], 'reconstitute': [66], 'a': [67], 'subcomplex': [69], 'active': [70], 'AAUAAA-dependent': [72], 'whereas': [74], 'CPSF100,': [75], 'CPSF73,': [76], 'symplekin': [78], 'dispensable.': [80], 'WDR33': [81, 107, 118, 150], 'required': [83], 'binding': [85], 'reconstituted': [87], 'AAUAAA-containing': [90], 'RNA': [91], 'can': [93, 102], 'be': [94], 'specifically': [95], 'UV': [96], 'cross-linked': [97], 'such': [99], 'RNAs,': [100], 'as': [101, 154], 'CPSF30.': [103], 'Transcriptome-wide': [104], 'identification': [105], 'targets': [108], 'by': [109, 156], 'photoactivatable': [110], 'ribonucleoside-enhanced': [111], 'cross-linking': [112], 'immunoprecipitation': [114], '(PAR-CLIP)': [115], 'showed': [116], 'binds': [119], 'very': [122], 'close': [123], 'AAUAAA': [126], 'vivo': [129], 'with': [130], 'high': [131], 'specificity.': [132], 'Thus,': [133], 'our': [134], 'data': [135], 'indicate': [136], 'large': [139], 'subunit': [141], 'participating': [142], 'recognition': [144], 'not': [152], 'CPSF160,': [153], 'suggested': [155], 'previous': [157], 'studies.': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2166494447', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 21}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 31}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 26}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-17T13:19:58.651888', 'created_date': '2016-06-24'}