Title: Comparison of ramosetron and ondansetron for prevention of nausea and vomiting after carboprost in LSCS patients under spinal anesthesia
Abstract:Background: Our aim of the study is to compare the effectiveness of ramosetron and ondansetron to prevent postoperative nausea and vomiting with carboprost in LSCS patients operated under spinal anest...Background: Our aim of the study is to compare the effectiveness of ramosetron and ondansetron to prevent postoperative nausea and vomiting with carboprost in LSCS patients operated under spinal anesthesia. Methods: 50 patients of age group 20-35 years and ASA physical status of grade I and II scheduled for LSCS with use of carboprost IM under spinal anesthesia. They were randomly allocated into two groups namely group O and group R. inj. ondansetron 4 mg and inj. ramosetron 0.3 mg IV respectively. Patients were observed intraoperatively and in the recovery room and ward for any episodes of nausea and vomiting. Rescue antiemetic was given if the patient had PONV score of 2 and was also recorded. All the patients were observed for side effects such as dizziness, headache, sedation or extrapyramidal reaction and treated accordingly upto 24 hours. Results: Incidence of nausea in immediate postoperative period was 8 % in group R compared to 20% in group O. Requirement of rescue antiemetic was minimum, i.e., 4% in group R. Incidence of side effects (headache, constipation and dizziness) was comparable in both the groups. Conclusions: Ramosetron is quite effective to prevent postoperative nausea and vomiting with carboprost in LSCS patients. It also reduces incidence of nausea in immediate postoperative period.Read More