Title: Physiological Society Symposium ‐ Vagal Control: From Axolotl to Man
Abstract: Experimental PhysiologyVolume 86, Issue 6 p. 817-823 Free Access Physiological Society Symposium - Vagal Control: From Axolotl to Man Vagal control of myocardial contractility in humans Barbara Casadei, Corresponding Author Barbara Casadei University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK Email: [email protected]Search for more papers by this author Barbara Casadei, Corresponding Author Barbara Casadei University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK Email: [email protected]Search for more papers by this author First published: 04 April 2005 https://doi.org/10.1111/j.1469-445X.2001.tb00050.xCitations: 19 Presented at the Oxford Meeting of the Physiological Society in March 2001. 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Journal of Physiology 528, 279–289. 10.1111/j.1469-7793.2000.00279.x CASPubMedWeb of Science®Google Scholar Bevegård, B. S., Castenfors, J. & Lindblad, L. E. (1977). Effect of carotid sinus stimulation on cardiac output and peripheral vascular resistance during changes in blood volume distribution in man. Acta Physiologica Scandinavica 101, 50–57. 10.1111/j.1748-1716.1977.tb05982.x CASPubMedWeb of Science®Google Scholar Bevegård, B. S. & Shepherd, J. T. (1966). Circulatory effects of stimulating the carotid arterial stretch receptors in man at rest and during exercise. Journal of Clinical Investigation 45, 132–142. 10.1172/JCI105317 CASPubMedWeb of Science®Google Scholar Bjurstedt, H., Rosenhamer, G. & Tydén, G. (1975). Cardiovascular responses to changes in carotid sinus transmural pressure in man. Acta Physiologica Scandinavica 94, 497–505. 10.1111/j.1748-1716.1975.tb05909.x PubMedWeb of Science®Google Scholar Boyett, M. R., Kirby, M. S., Orchard, C. H. & Roberts, A. (1988). The negative inotropic effect of acetylcholine on ferret ventricular myocardium. Journal of Physiology 404, 613–635. 10.1113/jphysiol.1988.sp017309 CASPubMedWeb of Science®Google Scholar Brunner, M. J., Greene, A. S., Frankle, A. E. & Shoukas, A. A. (1988). Carotid sinus baroreceptor control of splanchnic resistance and capacity. American Journal of Physiology 255, H1305–1310. CASPubMedWeb of Science®Google Scholar Casadei, B., Meyer, T., Coats, A. J. S., Conway, J. & Sleight, P. (1991). The stroke volume reduction by baroreceptor activation in human volunteer subjects is mediated by the vagus. Journal of Physiology 438, 87 P. Google Scholar Casadei, B., Meyer, T., Coats, A. J. S., Conway, J. & Sleight, P. (1992). Baroreflex control of stroke volume in man: An effect mediated by the vagus. Journal of Physiology 448, 539–550. 10.1113/jphysiol.1992.sp019056 PubMedWeb of Science®Google Scholar DeGeest, H., Levy, M. N. & Zieske, H. (1964). Negative inotropic effect of the vagus nerve upon the canine ventricle. Science 144, 1223–1225. 10.1126/science.144.3623.1223 CASPubMedWeb of Science®Google Scholar DeGeest, H., Levy, M. N., Zieske, H. & Lipman, R. I. (1965). Depression of ventricular contractility by stimulation of the vagus nerves. Circulation Research 17, 222–235. 10.1161/01.RES.17.3.222 CASPubMedWeb of Science®Google Scholar Deighton, N. M., Motomura, S., Borquez, D., Zerkowski, H. R., Doetsch, N. & Brodde, O. E. (1990). Muscarinic cholinoceptors in the human heart: demonstration, subclassification, and distribution. Naunyn-Schmiedeberg's Archives of Pharmacology 341, 14–21. 10.1007/BF00195052 CASPubMedWeb of Science®Google Scholar Du, X. Y., Schoemaker, R. G., Bos, E. & Saxena, P. R. (1995). Characterization of the positive and negative inotropic effects of acetylcholine in the human myocardium. European Journal of Pharmacology 284, 110–127. 10.1016/0014-2999(95)00384-W Google Scholar Eliakim, M., Bellet, S., Tawil, E. & Muller, O. (1961). Effect of vagal stimulation and acetylcholine on the ventricle. Studies in dogs with complete heart block. Circulation Research 9, 1372–1379. CASPubMedWeb of Science®Google Scholar Epstein, S. E., Beiser, G. D., Goldstein, R. E., Stampfer, M., Welchsler, A. S., Glick, G. & Braunwald, E. (1969). Circulatory effects of electrical stimulation of the carotid sinus nerves in man. Circulation 40, 269–276. 10.1161/01.CIR.40.3.269 CASPubMedWeb of Science®Google Scholar Epstein, S. E., Beiser, G. D., Stampfer, M. & Braunwald, E. (1968). Role of the venous system in baroreceptor-mediated reflexes in man. Journal of Clinical Investigation 47, 139–152. 10.1172/JCI105704 CASPubMedWeb of Science®Google Scholar Farrehi, C. (1972). Cardiovascular effects of carotid sinus nerve stimulation in resting man. Chest 61, 121–124. 10.1378/chest.61.2.121 CASPubMedWeb of Science®Google Scholar Gödecke, A., Heinicke, T., Kamkin, A., Kiseleva, I., Strasser, R. H., Decking, U. K. M., Stumpe, T., Isenberg, G. & Schrader, J. (2001). Inotropic response to β-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts. Journal of Physiology 532, 195–204. 10.1111/j.1469-7793.2001.0195g.x CASPubMedWeb of Science®Google Scholar Karlocai, K., Jokkel, G. & Kollai, M. (1998). Changes in left ventricular contractility with the phase of respiration. Journal of the Autonomic Nervous System 73, 86–92. 10.1016/S0165-1838(98)00116-7 CASPubMedWeb of Science®Google Scholar Kent, K. M., Epstein, S. E., Cooper, T. & Jacobowitz, D. M. (1974). Cholinergic innervation of the canine and human ventricular conducting system: Anatomic and electrophysiologic correlations. Circulation 50, 948–955. 10.1161/01.CIR.50.5.948 PubMedWeb of Science®Google Scholar Koumi, S. & Wasserstrom, J. A. (1994). Acetylcholine-sensitive muscarinic K+ channels in mammalian ventricular myocytes. American Journal of Physiology 266, H1812–1821. CASPubMedWeb of Science®Google Scholar Levy, M. N. (1971). Sympathetic-parasympathetic interactions in the heart. Circulation Research 29, 437–445. 10.1161/01.RES.29.5.437 CASPubMedWeb of Science®Google Scholar Levy, M. N. & Blattberg, B. (1976). The effect of vagal stimulation on the overflow of norepinephrine into the coronary sinus during cardiac sympathetic nerve stimulation in the dog. Circulation Research 38, 81–85. 10.1161/01.RES.38.2.81 CASPubMedWeb of Science®Google Scholar Lewis, M. E., Al-Khalidi, A. H., Bonser, R. S., Clutton-Brock, T., Morton, D., Paterson, D., Townend, J. N. & Coote, J. H. (2001). Vagus nerve stimulation decreases left ventricular contractility in vivo in the human and pig heart. Journal of Physiology 534, 547–552. 10.1111/j.1469-7793.2001.00547.x CASPubMedWeb of Science®Google Scholar Lindblad, L. E. (1977). Influence of age on sensitivity and effector mechanisms of the carotid baroreflex. Acta Physiologica Scandinavica 101, 43–49. 10.1111/j.1748-1716.1977.tb05981.x CASPubMedWeb of Science®Google Scholar Loewi, O. (1949). On the antagonism between pressor and depressor agents in the frog's heart. Journal of Pharmacology and Experimental Therapeutics 96, 295–304. CASPubMedWeb of Science®Google Scholar Löffelholz, K. & Pappano, A. J. (1985). The parasympathetic neuroeffector junction of the heart. Pharmacological Reviews 37, 1–24. CASPubMedWeb of Science®Google Scholar McMorn, S. O., Harrison, S. M., Zang, W. J., Yu, X. J. & Boyett, M. R. (1993). A direct negative inotropic effect of acetylcholine on rat ventricular myocytes. American Journal of Physiology 265, H1393–1400. CASPubMedWeb of Science®Google Scholar Mancia, G., Ferrari, A., Gregorini, L., Parati, G., Ferrari, M. C., Pomidossi, G. & Zanchetti, A. (1979). Control of blood pressure by carotid sinus baroreceptors in man. American Journal of Cardiology 44, 895–902. 10.1016/0002-9149(79)90220-0 CASPubMedWeb of Science®Google Scholar Nagata, K., Ye, C., Jain, M., Milstone, D. S., Liao, R. & Mortensen, R. M. (2000). G αi2 but not G αi3 is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes. Circulation Research 87, 903–909. 10.1161/01.RES.87.10.903 CASPubMedWeb of Science®Google Scholar Paterson, D. J. (2001). Nitric oxide and the autonomic regulation of cardiac excitability. Experimental Physiology 86, 1–12. 10.1113/eph8602169 CASPubMedWeb of Science®Google Scholar Roddie, I. C. & Shepherd, J. T. (1957). The effects of carotid artery compression in man with special reference to changes in vascular resistance in the limbs. Journal of Physiology 139, 377–384. 10.1113/jphysiol.1957.sp005898 CASPubMedWeb of Science®Google Scholar Rudolph, U., Spicher, K. & Birnbaumer, L. (1996). Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. Proceedings of the National Academy of Sciences of the USA 93, 3209–3214. 10.1073/pnas.93.8.3209 CASPubMedWeb of Science®Google Scholar Sears, C. E., Bryant, S. M., Wallis, H. L., Ashley, E. A. & Casadei, B. (2001). Is neuronal nitric oxide involved in the regulation of cardiac contraction and calcium current Heart 85, (suppl.) P33. Google Scholar Shoukas, A. A. (1982). Carotid sinus baroreceptor reflex control and epinephrine. Influence on capacitive and resistive properties of the total pulmonary vascular bed of the dog. Circulation Research 51, 95–101. 10.1161/01.RES.51.1.95 CASPubMedWeb of Science®Google Scholar Syrota, A., Comar, D., Paillottin, G., Davy, J. M., Aumont, M. C., Stulzaft, O. & Maziére, B. (1985). Muscarinic cholinergic receptor in the human heart evidenced under physiological conditions by positron emission tomography. Proceedings of the National Academy of Sciences of the USA 82, 584–588. 10.1073/pnas.82.2.584 CASPubMedWeb of Science®Google Scholar Ten Eick, R., Navrath, H., McDonald, T. F. & Trautwein, W. (1976). On the mechanism of the negative inotropic effect of acetylcholine. Pflügers Archiv 361, 207–213. 10.1007/BF00587284 CASPubMedGoogle Scholar Valenzuela, D., Han, X., Mende, U., Fankhauser, C., Mashimo, H., Huang, P., Pfeffer, J., Neer, E. J. & Fishman, M. C. (1997). G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. Proceedings of the National Academy of Sciences of the USA 94, 1727–1732. 10.1073/pnas.94.5.1727 CASPubMedWeb of Science®Google Scholar Vandecasteele, G., Eschenhagen, T., Scholz, H., Stein, B., Verde, I. & Fischmeister, R. (1999). Muscarinic and beta-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase. Nature Medicine 5, 331–334. 10.1038/6553 CASPubMedWeb of Science®Google Scholar Von Scheidt, W., Bohm, M., Stablein, A., Autenrieth, G. & Erdmann, E. (1992). Antiadrenergic effect of M-cholinoceptor stimulation on human ventricular contractility in vivo. American Journal of Physiology 263, H1927–1931. CASPubMedWeb of Science®Google Scholar Xenopoulos, N. P. & Applegate, R. J. (1994). The effect of vagal stimulation on left ventricular systolic and diastolic performance. American Journal of Physiology 266, H2167–2173. CASPubMedWeb of Science®Google Scholar Xu, K. Y., Huso, D. L., Dawson, T. M., Bredt, D. S. & Becker, L. C. (1999). Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proceedings of the National Academy of Sciences of the USA 96, 657–662. 10.1073/pnas.96.2.657 CASPubMedWeb of Science®Google Scholar Citing Literature Volume86, Issue6November 2001Pages 817-823 ReferencesRelatedInformation