Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2165897045', 'doi': 'https://doi.org/10.1093/nar/29.17.3621', 'title': 'ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs', 'display_name': 'ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs', 'publication_year': 2001, 'publication_date': '2001-09-01', 'ids': {'openalex': 'https://openalex.org/W2165897045', 'doi': 'https://doi.org/10.1093/nar/29.17.3621', 'mag': '2165897045', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11522832', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/55883'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/29.17.3621', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/29/17/3621/9906053/293621.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/nar/article-pdf/29/17/3621/9906053/293621.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085994366', 'display_name': 'Dimitri G. Pestov', 'orcid': 'https://orcid.org/0000-0002-1425-9879'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}, {'id': 'https://openalex.org/I907500627', 'display_name': 'Ashland (United States)', 'ror': 'https://ror.org/006nxzf98', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I907500627']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'D. G. Pestov', 'raw_affiliation_strings': ['Department of Molecular Genetics, M/C 669, University of Illinois at Chicago College of Medicine, 900 South Ashland Avenue, Chicago, IL 60607-7170, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, M/C 669, University of Illinois at Chicago College of Medicine, 900 South Ashland Avenue, Chicago, IL 60607-7170, USA', 'institution_ids': ['https://openalex.org/I39422238', 'https://openalex.org/I907500627']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5085994366'], 'corresponding_institution_ids': ['https://openalex.org/I39422238', 'https://openalex.org/I907500627'], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.884, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 70, 'citation_normalized_percentile': {'value': 0.874334, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '29', 'issue': '17', 'first_page': '3621', 'last_page': '3630'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gene-expression-regulation', 'display_name': 'Gene Expression Regulation', 'score': 0.510975}, {'id': 'https://openalex.org/keywords/ribosomal-protein', 'display_name': 'Ribosomal protein', 'score': 0.42701003}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.96760035}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.67178166}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.60592043}, {'id': 'https://openalex.org/C2779222958', 'wikidata': 'https://www.wikidata.org/wiki/Q45422', 'display_name': 'Yeast', 'level': 2, 'score': 0.5421539}, {'id': 'https://openalex.org/C67905577', 'wikidata': 'https://www.wikidata.org/wiki/Q215980', 'display_name': 'Ribosomal RNA', 'level': 3, 'score': 0.5419236}, {'id': 'https://openalex.org/C38062823', 'wikidata': 'https://www.wikidata.org/wiki/Q3408228', 'display_name': 'Ribosomal protein', 'level': 5, 'score': 0.42701003}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3337199}, {'id': 'https://openalex.org/C88478588', 'wikidata': 'https://www.wikidata.org/wiki/Q42244', 'display_name': 'Ribosome', 'level': 4, 'score': 0.26783812}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.26413274}], 'mesh': [{'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020043', 'descriptor_name': 'Genes, Essential', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012340', 'descriptor_name': 'RNA, Ribosomal, 5.8S', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015152', 'descriptor_name': 'Blotting, Northern', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017124', 'descriptor_name': 'Conserved Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005057', 'descriptor_name': 'Eukaryotic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020043', 'descriptor_name': 'Genes, Essential', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012323', 'descriptor_name': 'RNA Processing, Post-Transcriptional', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012340', 'descriptor_name': 'RNA, Ribosomal, 5.8S', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012340', 'descriptor_name': 'RNA, Ribosomal, 5.8S', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/29.17.3621', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/29/17/3621/9906053/293621.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc55883', 'pdf_url': 'https://europepmc.org/articles/pmc55883?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55883', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11522832', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/29.17.3621', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/29/17/3621/9906053/293621.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1421420331', 'https://openalex.org/W1522668252', 'https://openalex.org/W1537782690', 'https://openalex.org/W1585970141', 'https://openalex.org/W1600651336', 'https://openalex.org/W163498145', 'https://openalex.org/W1831257234', 'https://openalex.org/W1856170453', 'https://openalex.org/W1903251151', 'https://openalex.org/W1973046803', 'https://openalex.org/W1982385371', 'https://openalex.org/W1989849863', 'https://openalex.org/W1990900376', 'https://openalex.org/W2005982219', 'https://openalex.org/W2011991138', 'https://openalex.org/W2028007077', 'https://openalex.org/W2044920026', 'https://openalex.org/W2052562460', 'https://openalex.org/W2054400779', 'https://openalex.org/W2088876376', 'https://openalex.org/W2097382368', 'https://openalex.org/W2101903694', 'https://openalex.org/W2105637391', 'https://openalex.org/W2107025693', 'https://openalex.org/W2119288883', 'https://openalex.org/W2126219914', 'https://openalex.org/W2129648975', 'https://openalex.org/W2133997255', 'https://openalex.org/W2134725862', 'https://openalex.org/W2141011836', 'https://openalex.org/W2141885858', 'https://openalex.org/W2146503498', 'https://openalex.org/W2165093821', 'https://openalex.org/W2169333620', 'https://openalex.org/W230451612', 'https://openalex.org/W2313536581', 'https://openalex.org/W4252166161'], 'related_works': ['https://openalex.org/W4382918388', 'https://openalex.org/W4235426702', 'https://openalex.org/W2496745806', 'https://openalex.org/W2068583669', 'https://openalex.org/W2023403269', 'https://openalex.org/W2021333303', 'https://openalex.org/W1984145164', 'https://openalex.org/W1977540027', 'https://openalex.org/W1585402634', 'https://openalex.org/W1574378429'], 'abstract_inverted_index': {'We': [0], 'have': [1, 31], 'recently': [2], 'shown': [3], 'that': [4, 55, 92, 143, 176, 189], 'the': [5, 15, 33, 36, 45, 137, 158, 182], 'mammalian': [6, 147], 'nucleolar': [7], 'protein': [8], 'Bop1': [9, 174], 'is': [10, 57, 94, 122, 150], 'involved': [11], 'in': [12, 26, 65, 85, 164, 179], 'synthesis': [13, 97], 'of': [14, 35, 40, 62, 68, 98, 113, 131, 136, 154, 157, 171, 181], '28S': [16], 'and': [17, 22, 70, 80, 101, 119, 173], '5.8S': [18, 71], 'ribosomal': [19], 'RNAs': [20], '(rRNAs)': [21], 'large': [23, 159, 183], 'ribosome': [24, 160, 184], 'subunits': [25], 'mouse': [27], 'cells.': [28], 'Here': [29], 'we': [30], 'investigated': [32], 'functions': [34], 'Saccharomyces': [37], 'cerevisiae': [38], 'homolog': [39], 'Bop1,': [41, 149], 'Erb1p,': [42, 144], 'encoded': [43], 'by': [44, 168], 'previously': [46], 'uncharacterized': [47], 'open': [48], 'reading': [49], 'frame': [50], 'YMR049C.': [51], 'Gene': [52], 'disruption': [53, 170], 'showed': [54, 91], 'ERB1': [56], 'essential': [58], 'for': [59, 96, 152], 'viability.': [60], 'Depletion': [61], 'Erb1p': [63, 93, 132, 172], 'resulted': [64], 'a': [66, 77, 82], 'loss': [67], '25S': [69, 103], 'rRNAs': [72, 186], 'synthesis,': [73], 'while': [74], 'causing': [75], 'only': [76], 'moderate': [78], 'reduction': [79], 'not': [81], 'complete': [83], 'block': [84], '18S': [86], 'rRNA': [87, 104, 155], 'formation.': [88], 'Processing': [89], 'analysis': [90], 'required': [95, 151], '7S': [99], 'pre-rRNA': [100, 121], 'mature': [102], 'from': [105], '27SB': [106, 114, 120], 'pre-rRNA.': [107, 139], 'In': [108, 128], 'Erb1p‐depleted': [109], 'cells': [110], 'these': [111], 'products': [112], 'processing': [115, 135, 165], 'are': [116, 190], 'largely': [117], 'absent': [118], 'under-accumulated,': [123], 'apparently': [124], 'due': [125], 'to': [126], 'degradation.': [127], 'addition,': [129], 'depletion': [130], 'caused': [133, 167], 'delayed': [134], '35S': [138], 'These': [140], 'findings': [141], 'demonstrate': [142], 'like': [145], 'its': [146], 'counterpart': [148], 'formation': [153], 'components': [156], 'particles.': [161], 'The': [162], 'similarities': [163], 'defects': [166], 'functional': [169], 'suggest': [175], 'late': [177], 'steps': [178], 'maturation': [180], 'subunit': [185], 'employ': [187], 'mechanisms': [188], 'evolutionarily': [191], 'conserved': [192], 'throughout': [193], 'eukaryotes.': [194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165897045', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-15T21:20:14.851842', 'created_date': '2016-06-24'}