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4344, 4347, 4356, 4399, 4403, 4439, 4566, 4579, 4591, 4641, 4649, 4653, 4662, 4711, 4740, 4750, 4759, 4780, 4799, 4806, 4816], 'cell': [11, 339, 341, 344, 407, 422, 439, 444, 457, 488, 497, 505, 517, 535, 561, 776, 785, 799, 954, 1036, 1217, 1269, 1282, 1301, 1309, 1316, 1467, 1502, 1874, 1907, 2150, 2220, 2480, 2491, 2727, 2772, 2955, 3001, 3322, 3505, 3581, 3587, 3595, 4000, 4193, 4313, 4583, 4635, 4707, 4761, 4781, 4856], 'proliferation': [12, 494, 502, 509, 778, 796, 961, 1016, 1056, 1078, 1126, 1310, 1536, 2467, 2497, 2649, 2811, 2938, 2978, 3051, 3111], 'in': [13, 392, 490, 538, 549, 566, 580, 671, 735, 739, 770, 862, 872, 914, 951, 1031, 1039, 1079, 1113, 1281, 1284, 1341, 1435, 1460, 1475, 1501, 1554, 1558, 1594, 1605, 1626, 1652, 1664, 1720, 1736, 1753, 1790, 1911, 1917, 1922, 1924, 1949, 1961, 1970, 1994, 2007, 2025, 2036, 2051, 2068, 2207, 2233, 2255, 2264, 2301, 2323, 2516, 2543, 2549, 2629, 2648, 2667, 2674, 2720, 2782, 2830, 2834, 2861, 2947, 3024, 3037, 3181, 3245, 3297, 3320, 3392, 3402, 3428, 3713, 3771, 3795, 3827, 3847, 3920, 3951, 4051, 4058, 4145, 4153, 4199, 4214, 4226, 4253, 4389, 4441, 4486, 4614, 4659, 4666, 4756, 4777, 4811, 4823, 4832, 4862, 4872, 4878, 4889, 4928], 'the': [14, 295, 305, 328, 331, 360, 364, 368, 373, 377, 384, 393, 403, 406, 443, 456, 466, 486, 491, 500, 516, 521, 529, 534, 552, 560, 583, 601, 653, 679, 685, 690, 696, 703, 706, 714, 718, 723, 732, 736, 740, 744, 802, 807, 822, 839, 843, 855, 865, 874, 877, 884, 893, 898, 915, 925, 942, 946, 952, 974, 977, 1013, 1032, 1035, 1044, 1050, 1059, 1062, 1080, 1085, 1138, 1158, 1179, 1182, 1216, 1235, 1245, 1255, 1300, 1337, 1342, 1355, 1358, 1362, 1379, 1387, 1394, 1401, 1407, 1419, 1455, 1458, 1461, 1464, 1473, 1479, 1523, 1546, 1559, 1595, 1600, 1606, 1612, 1616, 1619, 1633, 1665, 1706, 1737, 1811, 1854, 1880, 1944, 1958, 1962, 1965, 1968, 1971, 1995, 2026, 2044, 2049, 2069, 2078, 2089, 2099, 2122, 2180, 2261, 2272, 2279, 2283, 2286, 2291, 2298, 2314, 2320, 2345, 2350, 2358, 2363, 2377, 2402, 2430, 2448, 2456, 2466, 2487, 2494, 2529, 2546, 2560, 2572, 2590, 2601, 2604, 2609, 2612, 2617, 2626, 2635, 2663, 2685, 2694, 2718, 2721, 2726, 2771, 2788, 2803, 2835, 2873, 2906, 2919, 2945, 2951, 2961, 2975, 2988, 2995, 3018, 3038, 3055, 3060, 3067, 3080, 3097, 3108, 3121, 3147, 3163, 3166, 3186, 3201, 3243, 3246, 3260, 3263, 3271, 3318, 3325, 3388, 3395, 3403, 3409, 3415, 3433, 3443, 3454, 3504, 3515, 3535, 3548, 3575, 3580, 3594, 3600, 3611, 3619, 3633, 3638, 3641, 3650, 3670, 3708, 3714, 3734, 3800, 3811, 3832, 3844, 3866, 3889, 3898, 3904, 3921, 3932, 3968, 3972, 3988, 3996, 3999, 4009, 4015, 4045, 4052, 4087, 4091, 4096, 4099, 4106, 4123, 4126, 4132, 4149, 4154, 4161, 4165, 4183, 4189, 4192, 4203, 4211, 4221, 4254, 4264, 4286, 4293, 4297, 4312, 4354, 4357, 4364, 4378, 4390, 4425, 4442, 4474, 4487, 4505, 4544, 4553, 4563, 4582, 4600, 4606, 4609, 4634, 4638, 4642, 4647, 4660, 4663, 4667, 4684, 4706, 4748, 4757, 4778, 4807, 4824, 4855, 4879, 4890], 'embryonic': [15, 332, 1091], 'retina': [16, 386, 687, 1609, 3248], 'zebrafish': [18, 333, 596, 4406, 4825, 4880], '(Danio': [19], 'rerio)': [20], 'Zheng': [21, 23, 137, 139], 'Li,': [22, 138], 'Li': [24, 140, 4239], 'Department': [25, 43, 63, 83, 109, 141, 159, 179, 199, 225], 'Biology,': [27, 45, 65, 85, 111, 119, 143, 161, 181, 201, 227, 235], 'University': [28, 46, 66, 86, 112, 120, 125, 144, 162, 182, 202, 228, 236, 241], 'Michigan,': [30, 48, 68, 88, 114, 122, 146, 164, 184, 204, 230, 238], 'Ann': [31, 49, 69, 89, 115, 127, 147, 165, 185, 205, 231, 243], 'Arbor,': [32, 50, 70, 90, 116, 128, 148, 166, 186, 206, 232, 244], 'MichiganSearch': [33, 51, 71, 91, 149, 167, 187, 207], 'for': [34, 52, 72, 92, 131, 150, 168, 188, 208, 247, 485, 528, 828, 892, 1470, 1717, 1857, 1902, 1946, 2231, 2246, 2662, 2792, 3099, 3225, 3599, 4612, 4716], 'more': [35, 53, 73, 93, 132, 151, 169, 189, 209, 248, 981, 996, 2640, 4430], 'papers': [36, 54, 74, 94, 133, 152, 170, 190, 210, 249], 'by': [37, 55, 75, 95, 134, 153, 171, 191, 211, 250, 448, 460, 496, 504, 511, 573, 765, 780, 798, 937, 999, 1094, 1137, 1146, 1261, 1274, 1404, 1411, 1423, 1439, 1526, 1545, 1674, 1941, 1984, 2115, 2468, 2521, 3013, 4179, 4187, 4461, 4469, 4672, 4795, 4838], 'this': [38, 56, 76, 96, 135, 154, 172, 192, 212, 251, 314, 709, 906, 1824, 2139, 2438, 2544, 2881, 2958, 3047, 3072, 3153, 3500, 3636, 3674, 3848, 3945, 4141, 4803, 4812], 'authorMinjie': [39, 155], 'Hu,': [40, 156], 'Minjie': [41, 157], 'Hu': [42, 158, 3157, 4235], 'authorMalgorzata': [57, 173], 'J.': [58, 61, 174, 177], 'Ochocinska,': [59, 175], 'Malgorzata': [60, 176], 'Ochocinska': [62, 178], 'authorNancy': [77, 193], 'M.': [78, 81, 194, 197], 'Joseph,': [79, 195], 'Nancy': [80, 196], 'Joseph': [82, 198], 'authorStephen': [97, 213], 'S.': [98, 104, 214, 220], 'Easter': [99, 105, 215, 221, 4237], 'Jr.,': [100, 216], 'Corresponding': [101, 217], 'Author': [102, 218], 'Stephen': [103, 219], 'Jr.': [106, 222], '[email': [107, 223], 'protected]': [108, 224], 'MichiganDepartment': [117, 233], '830': [123, 239], 'N.': [124, 240], 'Avenue,': [126, 242], 'MI': [129, 245], '48109-1048Search': [130, 246], 'author': [136, 252], 'First': [253], 'published:': [254], '25': [255], 'September': [256], '2000': [257, 591], 'https://doi.org/10.1002/1097-0177(2000)9999:9999<::AID-DVDY1063>3.0.CO;2-GCitations:': [258], '78AboutSectionsPDF': [259], 'ToolsRequest': [260], 'permissionExport': [261], 'citationAdd': [262], 'to': [263, 285, 308, 338, 350, 381, 399, 412, 551, 582, 610, 705, 713, 890, 965, 1190, 1220, 1352, 1446, 1491, 1504, 1645, 1688, 1730, 1821, 1835, 2137, 2158, 2179, 2203, 2239, 2297, 2398, 2461, 2464, 2486, 2616, 2703, 2738, 2968, 3049, 3052, 3064, 3258, 3302, 3332, 3343, 3432, 3488, 3522, 3603, 3614, 3622, 3632, 3700, 3744, 3816, 3965, 4018, 4044, 4120, 4196, 4326, 4478, 4515, 4524, 4535, 4552, 4597, 4637, 4698, 4705, 4786], 'favoritesTrack': [264], 'citation': [265], 'ShareShare': [266], 'Give': [267], 'accessShare': [268, 271], 'full': [269], 'text': [270], 'full-text': [272, 287, 311], 'accessPlease': [273], 'review': [274], 'our': [275, 818, 851, 1694, 2631, 4817], 'Terms': [276, 299], 'and': [277, 281, 293, 300, 319, 343, 371, 387, 402, 507, 524, 621, 641, 646, 664, 689, 708, 720, 738, 795, 929, 980, 985, 1009, 1021, 1055, 1096, 1117, 1145, 1169, 1194, 1199, 1263, 1321, 1361, 1368, 1396, 1457, 1563, 1587, 1611, 1640, 1734, 1743, 1767, 1784, 1861, 1892, 1988, 2043, 2061, 2109, 2124, 2176, 2184, 2188, 2215, 2259, 2305, 2313, 2352, 2381, 2407, 2423, 2493, 2569, 2574, 2585, 2669, 2693, 2700, 2705, 2802, 2816, 2872, 2892, 2905, 2918, 3003, 3028, 3044, 3094, 3114, 3158, 3172, 3300, 3407, 3421, 3498, 3525, 3635, 3646, 3741, 3747, 3756, 3766, 3804, 3906, 4023, 4029, 4033, 4081, 4122, 4168, 4236, 4243, 4245, 4271, 4291, 4303, 4329, 4333, 4336, 4375, 4385, 4408, 4428, 4435, 4455, 4530, 4543, 4574, 4595, 4617, 4621, 4630, 4674, 4727, 4742, 4814, 4845, 4848, 4925], 'Conditions': [278, 301], 'Use': [280], 'check': [282], 'box': [283], 'below': [284, 307], 'share': [286, 309], 'version': [288, 312], 'article.I': [290], 'have': [291, 543, 556, 588, 846, 859, 927, 932, 1003, 1109, 1272, 1295, 1312, 1851, 2462, 2499, 3063, 3128, 3177, 3552, 3565, 3668, 3676, 3717, 3793, 3911, 4415, 4445, 4519, 4646, 4771, 4876], 'read': [292], 'accept': [294], 'Wiley': [296], 'Online': [297], 'Library': [298], 'UseShareable': [303], 'LinkUse': [304], 'link': [306], 'a': [310, 512, 574, 772, 781, 1071, 1165, 1278, 1285, 1345, 1487, 1508, 1567, 1721, 1727, 1747, 1754, 1791, 1800, 1837, 1844, 1900, 1904, 1950, 2013, 2033, 2127, 2148, 2256, 2324, 2372, 2469, 2474, 2552, 2566, 2753, 2760, 2841, 2852, 2865, 2998, 3004, 3015, 3089, 3194, 3210, 3231, 3344, 3385, 3566, 3572, 3586, 3863, 3914, 3955, 3976, 4066, 4112, 4180, 4282, 4381, 4448, 4576, 4655, 4764, 4908], 'article': [315, 4142], 'with': [316, 335, 426, 474, 678, 1090, 1693, 2162, 2252, 2275, 2473, 2525, 2717, 2752, 2785, 3143, 3217, 3230, 3394, 3609, 3761, 3975, 4079, 4368, 4380, 4451, 4738], 'your': [317], 'friends': [318], 'colleagues.': [320], 'Learn': [321], 'more.Copy': [322], 'URL': [323], 'Abstract': [324], 'We': [325, 480, 519, 1002, 1709, 1850, 2134, 4518, 4560, 4801], 'describe': [326], 'light-microscopically': [327], 'development': [329, 4864], 'eye': [334, 369, 378, 394, 602, 674, 1063, 1251, 1343, 1766, 2027, 2651, 2901, 2915, 3715, 4156, 4166, 4256, 4268, 4366, 4379, 4668, 4881], 'particular': [336, 2082, 2095, 4834], 'attention': [337], 'number,': [340, 1503, 2492], 'proliferation,': [342, 777, 1489], 'death.': [345, 2956], 'The': [346, 595, 631, 660, 673, 759, 1025, 1123, 1430, 1452, 1520, 1589, 1648, 1931, 1955, 2021, 2039, 2059, 2074, 2293, 2386, 2413, 2505, 2556, 2596, 2653, 2677, 2797, 2857, 2887, 2900, 2914, 2935, 3007, 3102, 3131, 3265, 3313, 3380, 3424, 3591, 3949, 3984, 4093, 4137, 4249, 4259, 4277, 4307, 4321, 4870, 4894], 'period': [347, 943, 947, 2431, 3104, 3556, 4266, 4765], 'from': [348, 499, 608, 702, 801, 838, 1028, 1049, 1157, 1454, 1507, 1632, 2048, 2282, 2349, 2357, 2401, 2536, 2731, 2944, 2966, 3066, 3120, 3200, 3209, 3317, 3384, 3913, 3963, 3987, 4118, 4234, 4886], '16': [349, 609, 1353, 1377, 3494, 4327, 4479, 4516], '36': [351, 2411, 2586, 2711, 2743, 2912, 3533, 4340], 'hr': [352, 415, 612, 1207, 1226, 1233, 1239, 1247, 1510, 1719, 1948, 2758, 3359, 3364, 3491, 3570, 3704, 3882, 3970, 4084, 4493, 4511, 4526], 'post': [353, 613], 'fertilization': [354, 614], '(hpf)': [355, 615], 'comprises': [356], 'two': [357, 666, 745, 1388, 1480, 1620, 1768, 2101, 2557, 2859, 3030, 3298, 3479, 3899, 4010, 4127], 'phases;': [358], 'during': [359, 372, 453, 624, 792, 864, 941, 973, 1019, 2939, 3306, 3310, 3370, 3459, 3474, 3721, 3810, 3941, 3967, 4160, 4263, 4433, 4682, 4901], 'first': [361, 492, 522, 632, 2346, 2359, 3043, 3314], '(16–27': [362, 1248], 'hpf)': [363, 376, 1249, 3758, 4362], 'optic': [365, 597, 823, 840, 1359, 2613, 2870, 2888, 2930, 4359, 4386], 'vesicle': [366, 598, 661, 824, 844, 1360, 2889, 4360], 'becomes': [367], 'cup,': [370], 'second': [374, 3381], '(27–36': [375], 'cup': [379, 603, 675, 1252, 2902, 4167, 4269, 4367], 'begins': [380], 'differentiate': [382], 'into': [383, 600, 842, 3079, 4363, 4377], 'neural': [385, 686, 901, 978, 1363, 1963, 2627, 2927, 3247, 4466], 'pigmented': [388, 697, 3283], 'epithelium.': [389], 'All': [390, 1816, 2170, 3787], 'cells': [391, 472, 628, 879, 1048, 1131, 1141, 1150, 1186, 1258, 1340, 1382, 1413, 1425, 1434, 1441, 1562, 1625, 1733, 1818, 1860, 1897, 1915, 2011, 2024, 2040, 2065, 2093, 2206, 2390, 2421, 2443, 2666, 2679, 2768, 2839, 2846, 2964, 3061, 3117, 3197, 3244, 3329, 3391, 3401, 3427, 3447, 3458, 3549, 3563, 4152, 4252, 4301, 4898], 'primordium': [395], 'are': [396, 424, 629, 668, 1143, 1151, 1603, 1615, 1774, 1819, 1935, 2434, 2672, 2847, 2895, 2909, 2922, 3032, 3250, 3275, 3330, 3405, 3993, 4143, 4541, 4836], 'proliferative': [397, 1144, 1188, 2471, 3000, 3019, 3039, 3148, 3167, 4184], 'prior': [398, 1189, 1219, 3631, 4325, 4477, 4514], '28': [400, 638, 1191], 'hpf,': [401, 1354, 1406, 2824, 3437, 3461, 3513, 3534, 3943, 4529], 'length': [404, 537, 563], 'cycle': [408, 440, 536, 562, 1037, 1159, 1218, 3123, 3506, 3588, 3596, 4001, 4194, 4314, 4610, 4708, 4857], 'has': [409, 887, 962, 1083, 2199, 2903, 2916, 3353, 4481], 'been': [410, 860, 888, 963, 1110, 1296, 2201, 2500, 3129, 3170, 3354, 3677, 3718, 3794, 3826, 4483, 4868], 'estimated': [411, 2400, 2943, 3295, 3355, 3699], 'be': [413, 762, 815, 1224, 1325, 1374, 1505, 1836, 2445, 3011, 3303, 3333, 3604, 3701, 4703, 4793], '10': [414, 1206, 1225, 1232, 1509, 2477, 2786, 3358], 'at': [416, 429, 434, 577, 636, 1200, 1577, 1883, 1991, 2055, 2081, 2094, 2121, 2131, 2337, 2344, 2362, 2392, 2583, 2589, 2608, 2735, 2742, 3152, 3219, 3417, 3492, 3527, 3531, 3797, 3831, 3860, 3883, 3897, 3903, 4008, 4086, 4105, 4125, 4424, 4494, 4842, 4936], '24–28': [417, 2793], 'hpf': [418, 455, 639, 1192, 1202, 1222, 1378, 1660, 1716, 1926, 2433, 2450, 2587, 2689, 2702, 2712, 2737, 2744, 2794, 2815, 2941, 3084, 3212, 3308, 3352, 3372, 3495, 3697, 4022, 4328, 4335, 4480, 4496, 4548, 4903], '(Nawrocki,': [419, 1208, 2795, 3155, 3360, 3705], '1985).': [420, 2796, 3706], 'Our': [421], 'counts': [423], 'consistent': [425, 2751, 3142, 3974], 'that': [427, 430, 442, 545, 554, 586, 812, 882, 948, 1012, 1142, 1161, 1215, 1292, 1466, 1522, 1534, 1636, 1684, 1702, 1846, 1873, 2028, 2144, 2241, 2334, 2341, 2354, 2458, 2571, 2600, 2634, 2645, 2656, 2707, 2765, 2810, 3146, 3165, 3174, 3185, 3214, 3397, 3408, 3464, 3483, 3499, 3528, 3562, 3626, 3649, 3665, 3789, 3824, 3856, 3876, 3931, 3958, 3995, 4014, 4031, 4102, 4131, 4417, 4504, 4521, 4556, 4562, 4694, 4747, 4788, 4820, 4854, 4874, 4896, 4915, 4919, 4939], 'estimate': [428, 1689, 3315, 3382], 'age,': [431, 1348], 'but': [432, 452, 568, 905, 1153, 1403, 1486, 1656, 2347, 2360, 3927, 4004, 4038, 4186, 4485, 4911, 4945], 'not': [433, 909, 994, 1304, 1877, 2483, 2624, 3127, 3193, 4006, 4041, 4178, 4482, 4585], 'earlier': [435, 3144, 4810], 'ages.': [436, 3908], 'A': [437, 1498, 1978, 3035], '10-hr': [438, 3005], 'predicts': [441], 'number': [445, 458, 489, 1128, 1256, 1270, 1283, 1302, 1338, 1432, 1524, 1813, 1881, 2079, 2090, 2576, 2728, 2836, 2962, 3923, 3934, 4150, 4250, 4260, 4288], 'should': [446, 1259, 1271, 3126], 'increase': [447, 1030, 1087, 1237, 1260, 1280, 1305, 1474, 1500, 2719, 2749, 3023, 3339, 3919, 4871], '7%': [449], 'per': [450, 463, 1133, 1238, 2981, 2991, 3589], 'hr,': [451, 607, 2787, 2982, 3093, 3442, 3473, 3662, 3765, 3842, 3873], '16–24': [454, 1715, 2688, 2940, 3307, 3371, 3460, 3475, 3722, 3942, 4528], 'increased': [459, 1273, 1318, 1410, 1438, 1525, 2697, 2965, 4157, 4169], 'only': [461, 808, 1527, 2440, 2681, 2985, 3778, 4572], '1.5%': [462, 2980, 3341], 'hr.': [464, 2478, 3348, 3559, 3590, 3691, 4537], 'Despite': [465], 'low': [467, 508, 773, 1864, 1870, 2409, 2818, 3008], 'rate': [468, 774, 783, 1014, 1124, 1905, 2378, 2495, 2936, 2976, 2989, 3009, 3576, 3709, 4308, 4322, 4578], 'increase,': [470], 'all': [471, 477, 627, 1040, 1149, 1578, 1662, 2056, 2132, 2185, 2260, 3242, 3400, 3616, 3658, 3843, 3861, 3884, 4200, 4292, 4916], 'labeled': [473, 1940, 2542, 3137, 3656, 3870, 3892, 3989, 4062, 4920], 'bromo-deoxyuridine,': [475], 'so': [476, 1210, 1371, 1682, 1697, 1785, 1831, 2974, 3368, 3944, 4206, 4501], 'were': [478, 971, 993, 1231, 1266, 1383, 1630, 1642, 1663, 1681, 1777, 1787, 1805, 2029, 2041, 2046, 2135, 2160, 2173, 2191, 2222, 2229, 2269, 2295, 2310, 2317, 2331, 2335, 2342, 2355, 2396, 2459, 2519, 2580, 2607, 2650, 2660, 2680, 3136, 3730, 3759, 3767, 3776, 3781, 3790, 3838, 3869, 4036, 4077, 4103, 4295, 4570, 4951], 'proliferative.': [479, 630], 'considered': [481, 1834, 3042, 3538], 'three': [482, 857, 1006, 2537, 4767], 'possible': [483], 'explanations': [484], 'nearly-constant': [487], 'phase:': [493], 'balanced': [495, 503, 797, 1544], 'emigration': [498, 800, 805], 'eye,': [501, 953], 'death,': [506, 786], 'caused': [510, 3012], 'transient': [513], 'prolongation': [514, 3977], 'cycle.': [518, 1051, 2773, 3069, 3203, 4643], 'excluded': [520], 'two,': [523], 'found': [525, 1862, 4746], 'direct': [526, 2373], 'support': [527, 1463], 'third.': [530], 'Previous': [531, 4437], 'examinations': [532], 'vertebrate': [539, 1081, 4443, 4863], 'central': [540, 916], 'nervous': [541, 917], 'system': [542, 918], 'concluded': [544, 4416], 'it': [546, 569, 829, 1542, 1685, 1832, 2826, 4522, 4912], 'increases': [547, 1023, 4422, 4429, 4558], 'monotonically,': [548], 'contrast': [550, 581, 1976, 2167, 4736], 'modulation': [553, 1067, 4590, 4796], 'we': [555, 587, 1010, 1331, 1698, 2142, 2145, 2622, 3074, 3732, 4502, 4875], 'shown.': [557, 589], 'is': [564, 570, 662, 676, 806, 920, 956, 1070, 1135, 1187, 1204, 1365, 1516, 1833, 1960, 1982, 1989, 2750, 2781, 2876, 2890, 2984, 3041, 3192, 3256, 3268, 3430, 3542, 3571, 3618, 3637, 3947, 4111, 4419, 4491, 4549, 4593, 4679, 4687, 4696, 4724, 4784, 4858, 4882, 4913, 4932], 'well-known': [565], 'flies,': [567], 'generally': [571, 957, 1163, 1778, 1847], 'effected': [572], 'prolonged': [575, 3487], 'arrest': [576, 4935], 'one': [578, 809, 1718, 1760, 1841, 1956, 1966, 2265, 4783], 'phase,': [579], 'general': [584, 4554], 'deceleration': [585, 3601], '©': [590], 'Wiley-Liss,': [592], 'Inc.': [593], 'INTRODUCTION': [594], 'develops': [599], 'over': [604, 1512, 2429, 2447, 2642, 2687, 4763], 'about': [605, 637, 1205, 1549, 1658, 2441, 2452, 2682, 3467, 3471, 3489, 3493, 3702], '11': [606, 1246], '27': [611, 1399, 1405, 2701, 3683, 3757, 4027, 4334], '(Kimmel': [616, 4497], 'et': [617, 657, 726, 756, 831, 1100, 1173, 1483, 1740, 1828, 4240, 4412, 4463, 4498, 4627, 4690, 4731], 'al.,': [618, 658, 727, 757, 832, 1101, 1174, 1484, 1741, 1829, 4413, 4464, 4499, 4628, 4691, 4732], '1995;': [619], 'Schmitt': [620, 4244], 'Dowling,': [622, 1369], '1994),': [623, 4500], 'which': [625, 873, 2370, 2983, 3462, 3663, 3874, 4049, 4718, 4833], 'time': [626, 1885, 2394, 2755, 2821, 3510, 3612, 3620, 3801, 3833, 4107, 4222], 'terminal': [633, 4839], 'divisions': [634, 4768, 4841], 'occur': [635], '(Hu': [640, 1193, 4302, 4847], 'Easter,': [642, 1118, 1195, 3159, 4304, 4849], '1999;': [643, 1196], 'Nawrocki,': [644, 1197], '1985)': [645, 3361], 'neurogenesis': [647, 4173, 4275, 4822], 'continues': [648], 'thereafter': [649, 4171, 4432, 4534], 'throughout': [650, 753, 4220, 4953], 'much': [651, 2510], "fish's": [654], 'life': [655], '(Marcus': [656], '1999).': [659, 3160, 4305, 4850], 'flat,': [663], 'its': [665, 1985], 'layers': [667, 1437, 1481, 1654], 'nearly': [669, 751, 1384, 1661, 3657], 'equal': [670, 1385, 3431], 'thickness.': [672], 'round,': [677], 'lateral': [680, 1607, 3272, 4345], 'layer': [681, 692], '(LL)': [682], 'having': [683, 694, 3198], 'become': [684, 695], '(NR)': [688, 3249], 'medial': [691, 1596], '(ML)': [693], 'epithelium': [698, 1598], '(PE).': [699], 'Cells': [700], 'move': [701], 'ML': [704], 'LL,': [707], 'cellular': [710], 'rearrangement': [711, 1468], 'contributes': [712], 'simultaneous': [715], 'thickening': [716], 'LL/NR': [719, 1395, 1408, 1462], 'thinning': [721], 'ML/PE': [724, 1420, 1456], '(Li': [725, 755, 830, 1116, 1482], '2000).': [728, 758, 833], 'In': [729, 1178, 1678, 2097, 3692, 4472, 4588, 4599], 'spite': [730], 'radical': [733], 'changes': [734, 2647, 4540], 'shape': [737], 'relative': [741, 1644, 2178], 'volumes': [742, 749], 'layers,': [746], 'their': [747, 930, 934, 1690, 2302, 4722, 4923], 'combined': [748], 'remained': [750, 2408, 2817, 3526, 4281, 4337], 'constant': [752, 764, 895, 1288, 3940], 'morphogenesis': [754, 866, 967, 1020, 4163, 4270], 'volume': [760, 875, 896, 1289], 'could': [761, 1324, 2146, 3010, 3550, 3675, 3910], 'maintained': [763, 2706], 'four': [766, 3751, 4075], 'mechanisms,': [767], 'alone': [768], 'or': [769, 1227, 1242, 1315, 1319, 1450, 1541, 1808, 2266, 2759, 2972, 3021, 3026, 3229, 3362, 3470, 3496, 3684, 3785, 3798, 3829, 3980, 3982, 4512, 4624, 4797], 'combination:': [771], 'accompanied': [779], 'high': [782, 2708, 4338], 'volume-conservative': [787], 'cytokinesis': [788, 1293], '(as': [789], 'commonly': [790], 'occurs': [791, 4888], 'cleavage': [793], 'stages),': [794], 'vesicle.': [803], 'Cell': [804, 912, 1121, 1667, 1669, 4216], 'them': [811, 1746, 3087], 'can': [813, 4775, 4792], 'presently': [814], 'excluded,': [816], 'because': [817, 968, 2766, 3545, 4605, 4805, 4815, 4934], 'fate': [819], 'map': [820], 'provided': [825], 'no': [826, 4940], 'evidence': [827], 'Indeed,': [834], 'some': [835, 1047, 1155, 2767, 2820, 3509], 'slight': [836], 'immigration': [837], 'stalk': [841, 4391], 'may': [845, 1311, 4702], 'occurred': [847], '(Holt,': [848], '1980).': [849], 'To': [850, 3070, 3560, 3724], 'knowledge,': [852], 'none': [853, 3546], 'other': [856, 1700, 2181, 3728], 'mechanisms': [858, 3031], 'examined': [861, 2161, 2251, 3096, 3886], 'detail': [863], 'any': [868, 1884, 2393, 3727, 4760, 4789], 'tissue.': [869], 'Cleavage-like': [870], 'cytokinesis,': [871], 'daughter': [878], 'together': [880], 'equals': [881], 'mother': [885], 'cell,': [886], 'proposed': [889], 'account': [891], 'roughly': [894, 3452], 'developing': [899, 4155, 4255], 'amphibian': [900], 'plate': [902, 979], '(Gillette,': [903], '1944),': [904], 'hypothesis': [907, 3164], 'was': [908, 1495, 1537, 1543, 1671, 1686, 1876, 2250, 2633, 2639, 2942, 3112, 3150, 3215, 3294, 3373, 3414, 3440, 3448, 3466, 3485, 3698, 3895, 3938, 4176, 4213, 4218, 4508], 'tested': [910], 'further.': [911], 'death': [913, 955, 1317, 1547, 1670, 1875, 2221, 2481, 4217], '(CNS)': [919], 'often': [921], 'quite': [922, 4884], 'significant': [923], 'after': [924, 1657, 2235, 3088, 3350, 3377, 3695, 3799, 4020], 'neurons': [926, 4280, 4294, 4752, 4835], 'formed': [928], 'axons': [931], 'reached': [933], 'targets': [935], '(reviewed': [936, 1093, 4671], 'Oppenheim,': [938], '1991).': [939, 1104, 1177, 4471], 'But': [940, 990, 3888], 'before': [944, 4026], 'neurogenesis,': [945, 4683], 'concerns': [949], 'us': [950], 'less': [958, 1530, 1538, 1809, 2454, 2502, 3879, 4513], 'common.': [959], 'Slow': [960], 'suggested': [964], 'accompany': [966], 'mitotic': [969, 1564, 1649, 2517, 2547, 2578, 2605, 2636, 2678, 2724, 2838, 2893, 2907, 2920, 3068, 3122, 3188, 3202, 3446, 3736, 3779, 3806, 3819, 3845, 3867, 3893, 3925, 3936, 3990, 4063, 4100, 4840, 4941], 'figures': [970, 1565, 1650, 2606, 2894, 2908, 2921, 3780, 3807, 3820, 3846, 3868, 3894, 3937, 3991, 4064, 4101, 4942], 'sparse': [972], 'shaping': [975], 'numerous': [982], 'afterward': [983], '(Burnside': [984], 'Jacobson,': [986, 1103, 1176, 4470], '1968;': [987], 'Burt,': [988], '1943).': [989], 'these': [991, 1005, 1107, 1322, 1329, 1797, 1869, 2368, 2646, 3029, 3478], 'observations': [992, 4852], 'pursued': [995], 'rigorously,': [997], 'e.g.,': [998, 4714], 'counting': [1000], 'cells.': [1001, 1333, 1519, 1551, 1677, 2385, 4201], 'evaluated': [1004, 1672], 'possibilities': [1007], 'independently,': [1008], 'conclude': [1011], 'transiently': [1017, 1313, 3486, 3564], 'decreases': [1018, 1053], 'then': [1022, 1234, 1254, 1268, 1308, 1744, 3095, 3124, 3336, 4272, 4531, 4631, 4926], 'thereafter.': [1024], 'slowing': [1026, 4188, 4212], 'results': [1027, 1108, 4735, 4808], 'an': [1029, 1513, 1765, 2247, 2276, 2306, 2526, 2869, 2877, 3022, 3337, 3554, 3607, 3918, 4369, 4550, 4828], 'duration': [1033, 3410], '(TC)': [1038], 'cells,': [1041, 1494, 1583, 1939, 2113, 2725, 2971, 4290, 4654], 'rather': [1042], 'than': [1043, 1531, 1539, 2455, 2503, 2588, 2764, 3309, 3376, 3840, 3880, 3902, 4865], 'withdrawal': [1045], 'TC': [1052, 1069, 1089, 1167, 1203, 1230, 1265, 1511, 2475, 2761, 3025, 3175, 3293, 3345, 3349, 3369, 3439, 3465, 3484, 3567, 4400, 4418, 4440, 4476, 4490, 4507, 4557, 4567, 4592, 4603, 4873], 'again,': [1054], 'increases,': [1057], 'following': [1058, 2032, 3971], 'formation': [1060], 'cup.': [1064], 'This': [1065, 2194, 2748, 2774, 3161, 3255, 3540, 3909, 4110, 4700, 4930], 'up-and-down': [1066], 'novel': [1072], 'result,': [1073], 'as': [1074, 1154, 1306, 1344, 1418, 1566, 1781, 1799, 2012, 2225, 2619, 2778, 2840, 3356, 3678, 3680, 3685, 3687, 3783, 4065, 4633, 4946], 'previous': [1075], 'work': [1076], 'on': [1077, 1386, 1393, 1400, 1887, 1957, 1967, 2285, 2319, 2559, 2994, 4090], 'CNS': [1082, 4444], 'emphasized': [1084], 'monotonic': [1086], 'age': [1092, 2592, 3154, 3537, 4088, 4452], 'Alexiades': [1095, 4454], 'Cepko,': [1097, 1170, 4456], '1996;': [1098, 1171, 4457], 'Caviness': [1099, 1172, 4462], '2000;': [1102, 1175, 4465], 'Some': [1105], 'presented': [1111], 'previously': [1112, 2200, 2790, 4867], 'abstract': [1114], 'form': [1115, 2565, 2864], '1997).': [1119], 'RESULTS': [1120], 'Numbers': [1122], '(the': [1127, 3365, 4315], 'new': [1130, 1518, 2419], 'produced': [1132, 1637, 2657, 4837], 'hr)': [1134, 2780, 2992, 3524, 4569], 'governed': [1136], 'fraction': [1139, 2722, 3020, 3040, 3149, 3168, 3425, 3444, 3864, 3890, 4284], 'TC.': [1147, 3006, 4800], 'Initially': [1148], 'proliferative,': [1152], 'withdraw': [1156, 3065], 'those': [1160, 1593, 1604, 1646, 2333, 2340, 2353, 2399, 2670, 3624, 3770, 3822, 4715, 4739, 4917], 'remain': [1162, 2244, 3851], 'adopt': [1164], 'longer': [1166, 3305, 3375, 3839], '(Alexiades': [1168], 'presumptive': [1180], 'NR': [1181, 4826], 'entire': [1183, 1707], 'population': [1184, 2472, 3002, 3404], '1985),': [1198, 1209], '24': [1201, 1221, 2699, 2736, 3351, 3378, 3436, 3696, 4332, 4547], 'conventional': [1211], 'wisdom': [1212], 'would': [1213, 1223, 1240, 1290, 2243, 2444, 3062, 3850, 4769, 4943], 'predict': [1214], 'less.': [1228, 2511], 'If': [1229, 3324, 3836, 4773], 'fractional': [1236], 'be:': [1241], '7%.': [1243], 'During': [1244, 2957], 'formation,': [1253], '114%,': [1262], 'if': [1264, 1299, 3115, 3726], 'less,': [1267], 'even': [1275, 2151], 'more.': [1276], 'Such': [1277, 4644], 'large': [1279, 3686], 'tissue': [1286], 'indicate': [1291, 1592, 2809, 4575, 4853], 'must': [1294, 2498, 3176, 3667, 3716, 3792, 4719], 'volume-conservative.': [1297], 'Alternatively,': [1298], 'did': [1303, 2482, 2623, 3858, 4005, 4040, 4207], 'predicted,': [1307, 1532], 'decreased': [1314, 1422, 2812], 'both,': [1320, 3027], 'alternatives': [1323], 'checked': [1326], 'independently.': [1327], 'For': [1328, 3046], 'reasons,': [1330], 'counted': [1332, 1789, 2042], 'Figure': [1334, 1552, 1638, 1757, 1794, 1909, 2005, 2052, 2365, 2532, 2658, 2675, 2800, 2806, 2828, 2948, 3179, 3772, 3853, 3928, 3952, 4056, 4146, 4224, 4947], '1A': [1335, 2659], 'shows': [1336, 1759, 2367, 2508, 2534, 3855, 3930, 4095], 'function': [1346, 1568, 1801, 2014, 2842, 4067, 4791], '16–36': [1349], 'hpf.': [1350, 2412, 2595, 2886, 2899, 2913, 3221, 3312, 3379, 3476, 3723, 4341, 4517], '(Prior': [1351], 'boundary': [1356], 'between': [1357, 1478, 2698, 2813, 2822, 3511, 4331, 4527], 'tube': [1364, 2628, 4467], 'unclear': [1366], '(Schmitt': [1367], '1994)': [1370, 4414, 4629], 'numbers': [1372, 1380, 1560, 1629, 1691, 1798, 1865, 1871, 2387, 2804, 4278], 'cannot': [1373, 1898], 'computed.)': [1375], 'At': [1376, 2437], 'sides': [1389], '(665': [1390], '±': [1391, 1398, 1416, 1428, 1444, 1448, 1572, 2018, 2733, 2740, 4071], '26': [1392], '587': [1397], 'ML/PE),': [1402], 'had': [1409, 1421, 2769, 3118, 3169, 3553, 3627, 3808, 3825, 4134, 4866], '745': [1412], '(to': [1414, 1426], '1410': [1415], '58)': [1417], '432': [1424], '155': [1427], '3).': [1429], 'total': [1431, 1812, 2686, 3321, 3922, 3933, 4287], 'both': [1436, 1653, 2267, 2338, 3418], '313': [1440, 1493], '(from': [1442], '1252': [1443, 2967], '49': [1445, 3347, 3569], '1565': [1447], '56),': [1449], '25%.': [1451], 'loss': [1453], 'gain': [1459], 'idea': [1465], 'accounted': [1469], 'most': [1471, 3106, 3116, 3597, 4897], 'numerical': [1476], 'disparity': [1477], '2000),': [1485], 'little': [1488], 'enough': [1490], 'produce': [1492], 'also': [1496, 1852, 2192, 4446], 'required.': [1497], '114%': [1499], 'expected': [1506, 1540, 3056], '11-hr': [1514], 'interval,': [1515, 2451], '1427': [1517], 'fact': [1521], '313,': [1528], '1114': [1529, 1550, 2457], 'implies': [1533, 3173, 3463, 3664], 'either': [1535, 3014, 3357], '1Open': [1553], 'figure': [1555, 1912, 2008, 2831, 3182, 4059, 4227], 'viewerPowerPoint': [1556, 1913, 2009, 2832, 3183, 4060, 4228], 'Changes': [1557], 'age.': [1570, 2016, 2844, 4069, 4258, 4320], 'Means': [1571, 2017, 4070], 'SEM,': [1573], 'N': [1574], '=': [1575, 1999, 3290, 3682, 3689], '4': [1576, 2533, 2801], 'points.': [1579, 2057, 2133], 'A:': [1580, 1928, 2020, 2884, 4248], 'Number': [1581], 'including': [1584, 4405], 'interphase,': [1585], 'mitotic,': [1586], 'pyknotic.': [1588], 'lower': [1590, 2100, 3896], 'points': [1591, 1602, 1614, 2076, 2104], 'layer/pigmented': [1597], '(ML/PE),': [1599], 'middle': [1601], 'layer/neural': [1608], '(LL/NR),': [1610], 'upper': [1613], 'sum': [1617, 3639], '(Total).': [1621], 'B:': [1622, 1973, 2058, 2897, 3239, 4306], 'Percentage': [1623], 'M-phase.': [1627, 3817], 'Raw': [1628], 'obtained': [1631, 2114, 2223], 'same': [1634, 2321, 2654, 2882, 3416, 4298], 'sections': [1635, 2655, 3208], '1A,': [1639, 2746, 2807, 2949], 'percentages': [1641, 2045], 'computed': [1643], 'totals.': [1647], 'appeared': [1651], 'initially,': [1655], '20': [1659, 2000, 2594, 2898], 'LL/NR.': [1666], 'Death': [1668], 'quantitatively': [1673, 1878], 'scoring': [1675], 'pyknotic': [1676, 1825, 1896, 1979, 2064, 2112, 2262, 2315, 2384, 2389, 2420], 'sections,': [1679], 'they': [1680, 1786, 1804, 1890, 2084, 2242, 2309, 3125, 3857, 4950], 'few': [1683, 1748], 'impossible': [1687], 'reliably': [1692], 'sampling': [1695], 'method,': [1696], 'adopted': [1699], 'approaches': [1701], 'allowed': [1703], 'viewing': [1704, 2232, 2303], 'eye.': [1708], 'immersed': [1710], 'live': [1711, 1920], 'embryos': [1712, 2228, 2294, 4348], 'ages': [1714, 2541, 3419, 3752, 3862, 3885, 3901, 4076, 4129], 'solution': [1722, 1952], 'acridine': [1724, 1936], 'orange': [1725], '(AO),': [1726], 'substance': [1728], 'known': [1729], 'penetrate': [1731], 'dying': [1732, 1817, 2092, 2149, 2205], 'concentrate': [1735], 'nucleus': [1738, 1980], '(Abrams': [1739], '1993),': [1742], 'viewed': [1745, 2311], 'minutes': [1749], 'later,': [1750, 4085], 'still': [1751, 2245, 2300], 'alive,': [1752], 'fluorescence': [1755, 2163], 'microscope.': [1756], '2A': [1758], 'focal': [1761], 'plane': [1762], 'such': [1764], 'AO+': [1769, 2030, 2171], 'nuclei,': [1770, 2183], 'bright': [1771, 1932], '(yellow)': [1772], 'spheres,': [1773], 'evident.': [1775], 'They': [1776], 'well': [1779], 'separated,': [1780], 'shown': [1782, 1990, 2673, 4089, 4520, 4877], 'here,': [1783], 'easily': [1788], 'through-focus': [1792, 2257], 'examination.': [1793], '3A': [1795], 'gives': [1796], 'age;': [1803], 'always': [1806], '1%': [1807, 1951, 2037], 'nuclei.': [1815, 3101], 'believed': [1820], 'pass': [1822], 'through': [1823, 2271, 2880, 3503, 3579, 3814, 3998, 4191, 4311, 4581, 4608], 'state': [1826], '(Ellis': [1827], '1991),': [1830], 'reliable': [1838], '“snapshot”': [1839], 'phase': [1842, 3592, 4640], 'process': [1845], 'lasts': [1848], 'hours.': [1849, 4055], 'used': [1853, 2202, 3733], 'TUNEL': [1855], 'method': [1856], 'detecting': [1858], 'apoptotic': [1859], 'comparably': [1863], '(unpublished': [1866], 'results).': [1867], 'Although': [1868, 2621], 'suggest': [1872, 3482], 'important,': [1879], 'present': [1882, 2080, 2336, 2343, 2361, 3366, 4725], 'depends': [1886], 'how': [1888, 2509], 'long': [1889, 4564], 'persist,': [1891], 'therefore': [1893], 'snapshots': [1894, 2117], 'provide': [1899], 'basis': [1901, 2996], 'computing': [1903], 'loss.': [1908], '2Open': [1910], 'Dying': [1914, 2010], 'seen': [1916, 4658], 'photomicrographs': [1918, 3205], 'eyes': [1921, 2070, 2120, 2268, 2524, 2538, 3098], 'situ': [1923], '22': [1925, 3211], 'embryos.': [1927, 2073], 'Fluorescence': [1929, 3204], 'viewing.': [1930, 1977], 'spots': [1933], '(arrowheads)': [1934], 'orange-positive': [1937], '(AO+)': [1938], 'immersion': [1942, 2035], 'embryo': [1945, 2213, 3213], '1': [1947, 3764, 3841, 3872, 3881, 3969, 4083], 'AO.': [1954, 2038], 'left': [1959, 2561, 2858], 'retina,': [1964], 'right,': [1969], 'lens.': [1972], 'Differential': [1974], 'interference': [1975, 2166], '(arrowhead)': [1981], 'identified': [1983], 'globular/refractile': [1986, 2195], 'character,': [1987], 'higher': [1992, 2582], 'magnification': [1993], 'inset.': [1996], 'Scale': [1997, 3288], 'bars': [1998], 'μm.': [2001, 3292], 'CF,': [2002], 'choroid': [2003, 4371, 4383], 'fissure.': [2004], '3Open': [2006], 'SEM.': [2019, 4072], 'percentage': [2022, 2664, 2695, 4097], 'immediately': [2031], '1-hr': [2034, 2128, 3812], 'calculated': [2047], 'data': [2050, 2671, 2946], '1A.': [2053], 'N≥3': [2054], 'appearance': [2060, 2108, 2196, 2380, 2417], 'disappearance': [2062, 2110, 2382, 2424], '(globular/refractile': [2066], 'criterion)': [2067], 'living': [2072], 'uppermost': [2075], 'show': [2077, 2105, 2570, 2599, 3259], 'times;': [2083], 'represent': [2085], 'single': [2086], '“snapshots”—views': [2087], 'times.': [2096], 'contrast,': [2098, 3693], 'sets': [2102], 'rates': [2106, 2415], 'comparing': [2116], 'individual': [2119, 3328], 'beginning': [2123], 'end': [2125], 'period.': [2129], 'N=10': [2130], 'able': [2136], 'overcome': [2138], 'limitation': [2140], 'when': [2141, 2825, 3110, 3438, 3514, 4172, 4274, 4721, 4766], 'discovered': [2143], 'recognize': [2147], 'without': [2152], 'AO': [2153, 2159, 2403], 'staining.': [2154, 3264], 'Eyes': [2155], 'freshly': [2156], 'exposed': [2157], 'and/or': [2164], 'differential': [2165], '(DIC)': [2168], 'optics.': [2169], 'nuclei': [2172, 2190, 2263, 2316, 2548, 2579, 3135, 3617, 3625, 3659, 3775, 3788, 3823, 3961, 4918], 'small,': [2174, 2186], 'globular,': [2175, 2187], 'refractile': [2177, 2189], '(AO-)': [2182], 'AO+.': [2193], '(Fig.': [2197, 2405, 2745, 3138, 3190, 3450, 4904], '2B)': [2198], 'identify': [2204, 3821], 'C.': [2208], 'elegans,': [2209], 'another': [2210], 'famously': [2211], 'transparent': [2212], '(Sulston': [2214], 'Horvitz,': [2216], '1977).': [2217], 'Rates': [2218], 'directly,': [2224], 'follows.': [2226], 'Several': [2227], 'mounted': [2230], 'agarose': [2234], 'being': [2236], 'lightly': [2237], 'anesthetized': [2238], 'insure': [2240], 'hour.': [2248], 'Each': [2249], 'DIC': [2253], 'optics': [2254], 'series,': [2258], 'drawn': [2270, 2318], 'drawing': [2273], 'tube,': [2274], 'annotation': [2277], 'giving': [2278], 'depth': [2280], '(obtained': [2281], 'indication': [2284], 'fine': [2287], 'focus': [2288], 'knob': [2289], 'microscope).': [2292], 'returned': [2296], 'incubator,': [2299], 'chambers,': [2304], 'hour': [2307], 'later': [2308], 'again': [2312], 'sketch': [2322], 'different': [2325, 2540, 4885], 'color.': [2326], 'Three': [2327], 'classes': [2328], 'entries': [2330], 'scored:': [2332], 'observations,': [2339], 'absent': [2348, 2356], 'second,': [2351, 4013], 'second.': [2364], '3B': [2366], 'data,': [2369], 'give': [2371], 'sampled': [2374], 'measure': [2375, 4113], 'detected': [2391], '(Total)': [2395], 'similar': [2397], 'staining': [2404, 2522], '3A)': [2406], 'until': [2410, 2710, 2819, 3508, 3530, 4339], 'mean': [2414], '(Added/hr)': [2422], 'old': [2426], 'ones': [2427], '(Lost/hr)': [2428], '16–27': [2432, 2449], 'around': [2435, 4546], '5/hr.': [2436], 'rate,': [2439], '55': [2442], 'lost': [2446], '20×': [2453], 'predicted': [2460, 2993], 'disappeared': [2463], 'balance': [2465], 'fully': [2470], 'Therefore': [2479], 'contribute': [2484, 4042], 'importantly': [2485, 4043], 'near': [2488], 'constancy': [2489], 'considerably': [2501, 2581], 'predicted.': [2504], 'next': [2506, 4639], 'section': [2507, 2879], 'Modulated': [2512], 'Proliferation': [2513, 4175], 'Age-related': [2514], 'differences': [2515], 'activity': [2518, 2637, 3189], 'revealed': [2520], 'whole': [2523], 'antibody': [2527], 'against': [2528, 2551, 2851, 4907], 'H3': [2530], 'phosphohistone.': [2531], 'images': [2535, 2798], 'way,': [2545], 'red': [2550, 2848, 3224], 'green': [2553, 2853], 'nuclear': [2554, 2854, 3233], 'stain.': [2555], 'panels': [2558, 2598, 2860], 'each': [2563, 2862], 'row': [2564, 2863], 'stereo': [2567, 2866], 'pair': [2568, 2867], 'density': [2573], 'absolute': [2575], '14': [2584, 2885], 'intermediate': [2591, 3900, 4011, 4128], 'right': [2597, 2874], 'bulk': [2602], 'border': [2610], 'lumen,': [2614], 'adjacent': [2615], 'ML/PE,': [2618], 'expected.': [2620], 'examine': [2625, 3745], 'detail,': [2630], 'impression': [2632], 'there': [2638], 'uniform': [2641], 'time,': [2643], 'suggesting': [2644, 4693], 'specific.': [2652], 'scored': [2661, 3782], 'M-phase,': [2668, 3393, 3645, 4121], '1B.': [2676], '2–4%': [2683, 3455], '(compare': [2690, 2713], 'Fig.': [2691, 2714], '4B),': [2692], 'abruptly': [2696, 3520, 4323, 4423, 4532], '10–12%': [2704, 3449], 'value': [2709, 2775, 2789, 3529], '4C).': [2715], 'Concurrent': [2716], 'rose': [2729, 4261], 'steeply,': [2730], '1406': [2732, 2969], '42': [2734], '3812': [2739], '184': [2741], 'B).': [2747], 'doubling': [2754], '8.3': [2757], 'slightly': [2762], 'shorter': [2763], 'quit': [2770], '(hereafter': [2776], 'approximated': [2777], '8': [2779, 3363], 'reasonable': [2783], 'agreement': [2784], 'reported': [2791], 'B': [2808, 3140], '14–16': [2814], '24–27': [2823, 3512], 'increased.': [2827], '4Open': [2829], 'Variation': [2833], 'Mitotic': [2845], '(anti-phosphohistone': [2849], 'H3)': [2850], 'stain': [2855, 3234], '(SYTO-13).': [2856], 'vesicle/eye,': [2871], 'panel': [2875], 'optical': [2878], 'structure.': [2883], 'flat': [2891, 4358], 'numerous.': [2896, 2923], 'formed,': [2904], 'few.': [2910], 'C:': [2911, 4342], 'matured,': [2917], 'LE,': [2924, 3280], 'lens;': [2925, 3281], 'NT,': [2926], 'tube;': [2928], 'OV,': [2929], 'vesicle;': [2931], 'SE,': [2932], 'surface': [2933], 'ectoderm.': [2934], 'ignoring': [2950], 'small': [2952, 3679, 4283], 'effects': [2953], '8-hr': [2959], 'period,': [2960], '(154': [2970], '12%),': [2973], 'averaged': [2979], '21%': [2986, 3053], '(7%': [2990], 'completely': [2999, 3276], 'reduction': [3016], 'treated': [3033], 'next.': [3034], 'change': [3036, 3319], 'rejected.': [3045], 'mechanism': [3048], 'reduce': [3050], 'value,': [3057], '79%': [3058], 'evaluate': [3071], 'possibility,': [3073], 'injected': [3075, 3216, 3760, 4078], '5-bromo,': [3076], '2-deoxyuridine': [3077], '(BrdU)': [3078], 'yolk': [3081, 3286], '17': [3083, 3220], 'embryos,': [3085, 4404], 'sacrificed': [3086, 4082], 'survival': [3090, 3103, 3813], '5': [3092, 3661], 'BrdU-positive': [3100], 'spanned': [3105], 'interval': [3109], 'reduced,': [3113], 'withdrawn': [3119, 3199], 'labeled.': [3130], 'vast': [3132], 'majority': [3133], '5A,': [3139], '),': [3141], 'reports': [3145], '100%': [3151], '1985;': [3156], 'excludes': [3162], 'reduced': [3171, 3187, 3720, 4177], 'lengthened.': [3178], '5Open': [3180], 'Evidence': [3184], '4B)': [3191], 'result': [3195], 'transverse': [3207], 'BrdU': [3218, 3226, 3653, 4080, 4900], 'Nuclei': [3222], 'stained': [3223, 3768], '(B,': [3227], 'D)': [3228], 'blue': [3232], '(DAPI)': [3235], '(A,': [3236], 'C).': [3237], 'A,': [3238], 'Eye.': [3240], 'Nearly': [3241], 'BrdU+.': [3251], 'C,': [3252], 'D:': [3253], 'Trunk.': [3254], 'included': [3257], 'selectivity': [3261], 'hindbrain': [3266], '(HB)': [3267], 'BrdU+,': [3269], 'while': [3270], 'somites': [3273], '(SO)': [3274], 'BrdU-.': [3277, 3786, 3852], 'FB,': [3278], 'forebrain;': [3279], 'PE,': [3282], 'epithelium;': [3284], 'YG,': [3285], 'granules.': [3287], 'bar': [3289], '50': [3291], 'independently': [3296], 'ways': [3299], 'judged': [3301], '4–6×': [3304], '24–36': [3311], 'came': [3316, 3383], 'number.': [3323], 'cycles': [3326], 'assumed': [3331], 'phased': [3334], 'randomly,': [3335], 'hourly': [3338], 'corresponds': [3342], 'report),': [3367], '5–6×': [3374], 'comparison': [3386], 'fractions': [3389], 'assumptions': [3396], 'phases': [3398, 3729], 'random': [3406], 'M-phase': [3412, 3429, 3457, 3830, 3966, 3981, 4035], '(TM)': [3413], '(Quastler': [3420, 3740], 'Sherman,': [3422, 3742], '1959).': [3423], 'ratio:': [3434], 'After': [3435], '8–10': [3441, 3523, 4536], '1B),': [3451], '4×': [3453, 3468], 'greater,': [3469], '32–40': [3472], 'Thus,': [3477, 3707], 'independent': [3480], 'methods': [3481], '32–49': [3490, 3558, 4525], 'earlier,': [3497], 'sluggish': [3501], 'advance': [3502, 3516, 3997, 4016, 4190, 4204, 4310], 'persisted': [3507], 'speeded': [3517], 'up': [3518, 4025], '(=TC': [3519], 'shortened': [3521, 4533], 'least': [3532], 'oldest': [3536], 'here.': [3539, 3887], 'terminology': [3541], 'somewhat': [3543], 'misleading': [3544], 'actually': [3551], 'intermitotic': [3555, 4586], 'say': [3561], 'statement': [3573], 'progress': [3578, 4117, 4580, 4607], 'cycle;': [3582], 'i.e.,': [3583, 3917], '1/49': [3584], 'responsible': [3598], 'appears': [3602], 'S-phase.': [3605, 4215], 'Following': [3606], 'injection': [3608, 3651], 'BrdU,': [3610, 3762], 'needed': [3613, 3621], 'label': [3615, 3623], 'exited': [3628], 'S-phase': [3629, 3666, 3694, 3796, 4924], 'just': [3630], 'injection,': [3634, 3803, 3973], 'durations': [3642], 'G2,': [3644], 'G1.': [3647], 'Recall': [3648], 'described': [3654, 4447], 'above': [3655], 'within': [3660, 3871], 'occupied': [3669], 'remainder': [3671], 'TC;': [3673], '32-5': [3681], '49-5': [3688], '44': [3690], '7': [3703], 'DNA': [3711], 'synthesis': [3712], 'greatly': [3719], 'learn': [3725], 'decelerated,': [3731], '“labeled': [3735], 'figures”': [3737], 'experimental': [3738], 'paradigm': [3739], '1959)': [3743], 'G2': [3746, 3815, 3828, 3837, 3877, 3979, 4032, 4615, 4909, 4937], 'M-phases.': [3748], 'Embryos': [3749, 4073], '(15,': [3753], '19.5,': [3754], '22.5,': [3755], 'survived': [3763], 'like': [3769], '5.': [3773], 'Interphase': [3774], 'ignored;': [3777], 'BrdU+': [3784, 3791, 3805, 4104], 'progressed': [3809, 3962], 'BrdU-': [3818], 'injection.': [3835], 'experiment': [3849, 3992], '6': [3854, 3953], 'not;': [3859], 'indicates': [3875, 4130], 'lasted': [3878], 'earliest': [3905], 'latest': [3907], 'resulted': [3912], 'larger': [3915], 'denominator,': [3916], 'figures,': [3926], '1B': [3929, 4948], 'essentially': [3939], 'explanation': [3946], 'excluded.': [3948], 'dip': [3950, 4124], 'reflects': [3954], 'smaller': [3956], 'numerator;': [3957], 'is,': [3959], 'fewer': [3960], 'S-': [3964, 4119], 'both.': [3983], 'major': [3985, 4138], 'conclusions': [3986, 4139], 'first,': [3994], 'slowed': [4002, 4324], 'down,': [4003], 'stop,': [4007], 'ages;': [4012], 'began': [4017], 'slow': [4019], '15': [4021], 'sped': [4024], 'hpf;': [4028], 'third,': [4030], 'possibly': [4034], 'prolonged,': [4037], 'probably': [4039, 4509], 'lengthening': [4046, 4450], 'TC,': [4048], 'measured': [4050], '10s': [4053], '6Open': [4057], 'Percent': [4061], 'abscissa.': [4092], 'ordinate': [4094], 'sacrifice.': [4109], 'speed': [4115, 4133], 'slowed.': [4135], 'Conclusions': [4136], 'summarized': [4144], '7.': [4147], 'Briefly,': [4148], 'very': [4158], 'slowly': [4159], 'pre-neurogenic': [4162, 4265], 'rapidly': [4170], 'began.': [4174, 4276], 'diminution': [4181], 'fraction,': [4185], '(equivalent': [4195], 'increasing': [4197], 'TC)': [4198, 4318], 'When': [4202, 4677], 'accelerated,': [4205], 'proliferation.': [4208], 'Most': [4209], 'negligible': [4219], 'examined.': [4223], '7Open': [4225], 'Summary': [4229], 'results,': [4231], 'incorporating': [4232], 'information': [4233], '(1999),': [4238], 'al.': [4241], '(2000),': [4242], 'Dowling': [4246], '(1994).': [4247], 'vs.': [4257, 4319], 'sluggishly': [4262], 'explosively': [4273], 'type,': [4299], 'ganglion': [4300], 'inverse': [4316], 'accelerated': [4330], 'Sketches': [4343], 'views': [4346], '(dorsal': [4349], 'up,': [4350], 'anterior': [4351], 'left),': [4352], 'illustrating': [4353], 'transformation': [4355], '(16': [4361], 'spherical': [4365], 'open': [4370], 'fissure': [4372, 4384], '(24': [4373], 'hpf),': [4374], 'finally': [4376], 'fused': [4382], 'nerve': [4387], 'fibers': [4388], '(36': [4392], 'hpf).': [4393], 'DISCUSSION': [4394], 'Vs.': [4396], 'Monotonic': [4397], 'Increase': [4398], 'Numerous': [4401], 'studies': [4402], '(Kane': [4407], 'Kimmel,': [4409], '1993;': [4410], 'Kimmel': [4411], 'initially': [4420], 'short,': [4421], 'midblastula': [4426], 'transition,': [4427], 'gradually': [4431], 'gastrulation': [4434], 'organogenesis.': [4436], 'determinations': [4438], 'steady': [4449], '(NR:': [4453], 'cerebral': [4458], 'cortex': [4459], 'reviewed': [4460, 4468], 'zebrafish,': [4473], 'ocular': [4475, 4506], 'determined,': [4484], 'spinal': [4488], 'cord,': [4489], '5–8': [4492], '15–20': [4495], 'assume': [4503], '9': [4510], 'lengthened': [4523], 'These': [4538, 4734, 4851], 'abrupt': [4539], 'unusual,': [4542], 'shortening': [4545], 'exception': [4551], 'rule': [4555], 'monotonically.': [4559], 'emphasize': [4561], 'values': [4565], '(32–49': [4568], 'experienced': [4571], 'transiently,': [4573], 'decelerated': [4577], 'cycle,': [4584], 'intervals.': [4587], 'Drosophila,': [4589], 'widespread': [4594], 'important': [4596, 4697], 'development.': [4598], 'imaginal': [4601, 4669, 4892], 'disks,': [4602], 'lengthens': [4604], 'arrests': [4611, 4645], 'hours': [4613], '(Fain': [4616], 'Stevens,': [4618], '1982;': [4619], 'Graves': [4620], 'Schubiger,': [4622], '1982)': [4623], 'G1': [4625], '(Thomas': [4626], 'shortens': [4632], 'advances': [4636], 'effect': [4648], 'synchronizing': [4650], 'local': [4651], 'populations': [4652], 'phenomenon': [4656], 'best': [4657], 'vicinity': [4661], 'morphogenetic': [4664], 'furrow': [4665], 'disk': [4670], 'Thomas': [4673], 'Zipursky,': [4675], '1994).': [4676], 'synchronization': [4678, 4695, 4798], 'genetically': [4680], 'perturbed': [4681], 'ommatidial': [4685], 'pattern': [4686], 'abnormal': [4688], '(Penton': [4689], '1997),': [4692], 'patterning.': [4699], 'importance': [4701], 'related': [4704], 'phase-specific': [4709], 'expression': [4710], 'certain': [4712], 'genes;': [4713], 'receptors': [4717], 'appear': [4720], 'ligand': [4723], '(McConnell': [4726], 'Kaznowski,': [4728], '1991;': [4729], 'Urdiales': [4730], '1998).': [4733], 'sharply': [4737], 'Harris': [4741], 'Hartenstein': [4743], '(1991),': [4744], 'who': [4745], 'differentiation': [4749, 4774], 'retinal': [4751], 'proceeded': [4753], 'grossly': [4754], 'normally': [4755, 4770], 'absence': [4758, 4779], 'division': [4762], 'occurred.': [4772], 'proceed': [4776], 'division,': [4782], 'tempted': [4785], 'doubt': [4787], 'developmental': [4790], 'served': [4794], 'resist': [4802], 'temptation': [4804], 'mentioned': [4809], 'paragraph': [4813], 'recent': [4818], 'demonstration': [4819, 4895], 'early': [4821, 4921], 'follows': [4827], 'intricate': [4829], 'spatiotemporal': [4830], 'program': [4831], 'stereotyped': [4843], 'times': [4844], 'places': [4846], 'under': [4859], 'closer': [4860], 'control': [4861], 'thought.': [4869], 'mechanistically': [4883], 'what': [4887], 'fly': [4891], 'disks.': [4893], 'incorporated': [4899], '17–22': [4902], '5)': [4905], 'argues': [4906], 'arrest,': [4910], 'conceivable': [4914], 'completed': [4922], 'arrested': [4927], 'G2.': [4929], 'possibility': [4931], 'unlikely': [4933], 'means': [4938], 'form,': [4944], 'summarizes,': [4949], 'observed': [4952]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165725463', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-14T20:06:27.485553', 'created_date': '2016-06-24'}