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[76], 'completed': [77], 'phase': [79], '3': [80], 'intravenous': [83], 'which': [92], 'were': [94, 272], 'available.': [95], 'Retrospective': [96], 'checks': [97], 'confirmed': [98], 'that': [99], 'no': [100, 113, 379, 388], 'eligible': [101], 'been': [104], 'omitted.': [105], 'defined': [107, 119], 'as': [112], 'significant': [114, 389], 'disability': [115], 'at': [116, 398], '3–6': [117, 441], 'months,': [118], 'by': [120, 136, 146, 440, 447], 'modified': [122], 'Rankin': [123], 'Score': [124], '0': [126], '1.': [128], 'Additional': [129], 'outcomes': [130], 'symptomatic': [132, 286], 'intracranial': [133, 159, 287, 325, 346, 435, 489], 'haemorrhage': [134, 140, 154, 160, 288, 292, 326, 347, 436, 490], '(defined': [135], 'type': [137, 152], '2': [138, 153, 290], 'parenchymal': [139, 151, 291], 'within': [141, 155, 161, 184, 327, 461, 511], '7': [142, 162, 328], 'days': [143, 329, 400, 495], 'and,': [144], 'separately,': [145], 'SITS-MOST': [148, 309], 'definition': [149, 293, 310], '36': [156], 'h),': [157], 'fatal': [158, 324, 345, 488], 'days,': [163], '90-day': [165], 'mortality.FindingsAlteplase': [166], 'increased': [167, 282, 429, 485], 'odds': [169, 284, 503], 'outcome,': [174], 'earlier': [176, 518], 'associated': [178, 520], 'bigger': [180, 369, 522], 'proportional': [181, 523], 'benefit.': [182], 'Treatment': [183], '3·0': [185, 218, 462, 471], 'h': [186, 249, 463, 513], 'resulted': [187, 224, 250], '259': [193], '(32·9%)': [194], '787': [196], 'received': [199, 207], 'versus': [201, 233, 259, 408], '176': [202], '(23·1%)': [203], '762': [205], 'control': [208, 413], '(OR': [209, 238, 264], '1·75,': [210], '95%': [211, 240, 266, 305, 318, 337, 418], 'CI': [212, 241, 267, 306, 319, 338, 419], '1·35–2·27);': [213], 'delay': [214, 244], 'greater': [216], 'than': [217, 247], 'h,': [219, 223, 472], 'up': [220, 473], 'to': [221, 366, 474], '4·5': [222, 248, 475, 512], '485': [229], '(35·3%)': [230], '1375': [232], '432': [234], '(30·1%)': [235], '1437': [237], '1·26,': [239], '1·05–1·51);': [242], 'more': [246, 374], '401': [255], '(32·6%)': [256], '1229': [258], '357': [260], '(30·6%)': [261], '1166': [263], '1·15,': [265], '0·95–1·40).': [268], 'Proportional': [269], 'benefits': [271], 'similar': [273, 351], 'irrespective': [274, 352], 'age': [276, 478], 'severity.': [279], 'Alteplase': [280], 'significantly': [281, 499], '(type': [289], '231': [294], '[6·8%]': [295], '3391': [297], 'vs': [298, 313, 332], '44': [299], '[1·3%]': [300], '3365,': [302], 'OR': [303, 316, 335], '5·55,': [304], '4·01–7·70,': [307], 'p<0·0001;': [308], '124': [311], '[3·7%]': [312], '19': [314], '[0·6%],': [315], '6·67,': [317], '4·11–10·84,': [320], 'p<0·0001)': [321], '(91': [330], '[2·7%]': [331], '13': [333], '[0·4%];': [334], '7·14,': [336], '3·98–12·79,': [339], 'p<0·0001).': [340], 'The': [341], 'relative': [342], 'increase': [343, 451], 'was': [350, 368, 378, 401, 445], 'delay,': [355], 'age,': [356], 'severity,': [359, 481], 'absolute': [362, 428, 450], 'excess': [363, 380], 'risk': [364, 430, 444, 486], 'attributable': [365], 'There': [377], 'other': [382], 'early': [383, 432], 'causes': [384, 393], 'death': [386, 433], 'effect': [390], 'on': [391], 'later': [392], 'death.': [395], 'Consequently,': [396], 'mortality': [397], '90': [399], '608': [402], '(17·9%)': [403], 'group': [407, 414], '556': [409], '(16·5%)': [410], '(hazard': [415], 'ratio': [416], '1·11,': [417], '0·99–1·25,': [420], 'p=0·07).': [421], 'Taken': [422], 'together,': [423], 'therefore,': [424], 'despite': [425, 483], 'an': [426, 448, 484], 'average': [427, 449], '2%,': [439], 'months': [442], 'this': [443], 'offset': [446], 'disability-free': [453], 'survival': [454], '10%': [457], 'treated': [460, 469], '5%': [466], 'h.InterpretationIrrespective': [476], 'during': [491], 'first': [493], 'few': [494], 'treatment,': [497], 'improves': [500], 'overall': [502], 'when': [509], 'delivered': [510], 'benefits.FundingUK': [524], 'Medical': [525], 'Research': [526], 'Council,': [527], 'British': [528], 'Heart': [529], 'Foundation,': [530], 'University': [531, 534], 'Glasgow,': [533], 'Edinburgh.': [536]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165568749', 'counts_by_year': [{'year': 2024, 'cited_by_count': 142}, {'year': 2023, 'cited_by_count': 244}, {'year': 2022, 'cited_by_count': 252}, {'year': 2021, 'cited_by_count': 278}, {'year': 2020, 'cited_by_count': 249}, {'year': 2019, 'cited_by_count': 225}, {'year': 2018, 'cited_by_count': 193}, {'year': 2017, 'cited_by_count': 178}, {'year': 2016, 'cited_by_count': 185}, {'year': 2015, 'cited_by_count': 159}, {'year': 2014, 'cited_by_count': 24}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-16T22:48:31.230308', 'created_date': '2016-06-24'}