Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2165501526', 'doi': 'https://doi.org/10.1002/jnr.22210', 'title': 'A stable G‐quartet binds to a huntingtin protein fragment containing expanded polyglutamine tracks', 'display_name': 'A stable G‐quartet binds to a huntingtin protein fragment containing expanded polyglutamine tracks', 'publication_year': 2009, 'publication_date': '2009-08-24', 'ids': {'openalex': 'https://openalex.org/W2165501526', 'doi': 'https://doi.org/10.1002/jnr.22210', 'mag': '2165501526', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19705452'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jnr.22210', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76417895', 'display_name': 'Journal of Neuroscience Research', 'issn_l': '0360-4012', 'issn': ['0360-4012', '1097-4547'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022173922', 'display_name': 'Sarah Yerkes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I88694374', 'display_name': 'Marshall University', 'ror': 'https://ror.org/02erqft81', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I88694374']}, {'id': 'https://openalex.org/I86501945', 'display_name': 'University of Delaware', 'ror': 'https://ror.org/01sbq1a82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86501945']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarah Yerkes', 'raw_affiliation_strings': ['Department of Biological Science, University of Delaware, Newark, Delaware', 'Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, West Virginia'], 'affiliations': [{'raw_affiliation_string': 'Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, West Virginia', 'institution_ids': ['https://openalex.org/I88694374']}, {'raw_affiliation_string': 'Department of Biological Science, University of Delaware, Newark, Delaware', 'institution_ids': ['https://openalex.org/I86501945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022243508', 'display_name': 'James Vesenka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I275799156', 'display_name': 'University of New England', 'ror': 'https://ror.org/02n2ava60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I275799156']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Vesenka', 'raw_affiliation_strings': ['Department of Chemistry and Physics, University of New England, Biddeford, Maine'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Physics, University of New England, Biddeford, Maine', 'institution_ids': ['https://openalex.org/I275799156']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081138565', 'display_name': 'Eric B. Kmiec', 'orcid': 'https://orcid.org/0000-0003-4680-5325'}, 'institutions': [{'id': 'https://openalex.org/I88694374', 'display_name': 'Marshall University', 'ror': 'https://ror.org/02erqft81', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I88694374']}, {'id': 'https://openalex.org/I86501945', 'display_name': 'University of Delaware', 'ror': 'https://ror.org/01sbq1a82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86501945']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Eric B. Kmiec', 'raw_affiliation_strings': ['Department of Biological Science, University of Delaware, Newark, Delaware', 'Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, West Virginia'], 'affiliations': [{'raw_affiliation_string': 'Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, West Virginia', 'institution_ids': ['https://openalex.org/I88694374']}, {'raw_affiliation_string': 'Department of Biological Science, University of Delaware, Newark, Delaware', 'institution_ids': ['https://openalex.org/I86501945']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5081138565'], 'corresponding_institution_ids': ['https://openalex.org/I88694374', 'https://openalex.org/I86501945'], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.268, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.516027, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '88', 'issue': '2', 'first_page': '335', 'last_page': '345'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10949', 'display_name': 'Molecular Mechanisms of Neurodegenerative Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10949', 'display_name': 'Molecular Mechanisms of Neurodegenerative Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10497', 'display_name': 'Genomic Expression and Function in Yeast Organism', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9828, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/huntingtin-protein', 'display_name': 'Huntingtin Protein', 'score': 0.75946295}, {'id': 'https://openalex.org/keywords/polyglutamine-tract', 'display_name': 'Polyglutamine tract', 'score': 0.65319496}, {'id': 'https://openalex.org/keywords/mutant-protein', 'display_name': 'Mutant protein', 'score': 0.5007639}, {'id': 'https://openalex.org/keywords/protein-aggregation', 'display_name': 'Protein Aggregation', 'score': 0.478137}], 'concepts': [{'id': 'https://openalex.org/C2781427258', 'wikidata': 'https://www.wikidata.org/wiki/Q2620886', 'display_name': 'Huntingtin', 'level': 4, 'score': 0.94102967}, {'id': 'https://openalex.org/C2910011555', 'wikidata': 'https://www.wikidata.org/wiki/Q2620886', 'display_name': 'Huntingtin Protein', 'level': 5, 'score': 0.75946295}, {'id': 'https://openalex.org/C2777616661', 'wikidata': 'https://www.wikidata.org/wiki/Q7226416', 'display_name': 'Polyglutamine tract', 'level': 5, 'score': 0.65319496}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.600192}, {'id': 'https://openalex.org/C136238340', 'wikidata': 'https://www.wikidata.org/wiki/Q7251455', 'display_name': 'Protein aggregation', 'level': 2, 'score': 0.55014503}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5186995}, {'id': 'https://openalex.org/C2779926675', 'wikidata': 'https://www.wikidata.org/wiki/Q6943700', 'display_name': 'Mutant protein', 'level': 4, 'score': 0.5007639}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4800221}, {'id': 'https://openalex.org/C2777995097', 'wikidata': 'https://www.wikidata.org/wiki/Q422462', 'display_name': 'Guanosine', 'level': 2, 'score': 0.46212977}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45173463}, {'id': 'https://openalex.org/C123894998', 'wikidata': 'https://www.wikidata.org/wiki/Q425158', 'display_name': 'Fusion protein', 'level': 4, 'score': 0.42831537}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41217127}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3448596}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23357028}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D054856', 'descriptor_name': 'G-Quadruplexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011099', 'descriptor_name': 'Polyglutamic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001710', 'descriptor_name': 'Biotin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004587', 'descriptor_name': 'Electrophoresis, Agar Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018625', 'descriptor_name': 'Microscopy, Atomic Force', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011099', 'descriptor_name': 'Polyglutamic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011099', 'descriptor_name': 'Polyglutamic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055503', 'descriptor_name': 'Protein Multimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019809', 'descriptor_name': 'Streptavidin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jnr.22210', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76417895', 'display_name': 'Journal of Neuroscience Research', 'issn_l': '0360-4012', 'issn': ['0360-4012', '1097-4547'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19705452', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.51, 'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W129247355', 'https://openalex.org/W1560120988', 'https://openalex.org/W1565076702', 'https://openalex.org/W1968619073', 'https://openalex.org/W1970419257', 'https://openalex.org/W1976863089', 'https://openalex.org/W1982623268', 'https://openalex.org/W1982668924', 'https://openalex.org/W1983644993', 'https://openalex.org/W1985836613', 'https://openalex.org/W1987711136', 'https://openalex.org/W1997369314', 'https://openalex.org/W2020720677', 'https://openalex.org/W2031598812', 'https://openalex.org/W2033394951', 'https://openalex.org/W2033526098', 'https://openalex.org/W2042450595', 'https://openalex.org/W2044530067', 'https://openalex.org/W2052344543', 'https://openalex.org/W2057499896', 'https://openalex.org/W2062682951', 'https://openalex.org/W2066954106', 'https://openalex.org/W2086113348', 'https://openalex.org/W2089355762', 'https://openalex.org/W2091065275', 'https://openalex.org/W2092377322', 'https://openalex.org/W2100831731', 'https://openalex.org/W2111149100', 'https://openalex.org/W2115207187', 'https://openalex.org/W2120721020', 'https://openalex.org/W2124258497', 'https://openalex.org/W2131633411', 'https://openalex.org/W2162057703', 'https://openalex.org/W2164876360', 'https://openalex.org/W2169397639', 'https://openalex.org/W2169579807', 'https://openalex.org/W2171830519'], 'related_works': ['https://openalex.org/W3004314980', 'https://openalex.org/W2982548291', 'https://openalex.org/W2797031857', 'https://openalex.org/W2789662870', 'https://openalex.org/W2765989831', 'https://openalex.org/W2185606964', 'https://openalex.org/W2147469675', 'https://openalex.org/W2130196517', 'https://openalex.org/W2024436194', 'https://openalex.org/W1977983193'], 'abstract_inverted_index': {'Abstract': [0], "Huntington's": [1], 'disease': [2, 18, 73], '(HD)': [3], 'is': [4, 10, 19, 50, 75, 155], 'a': [5, 130, 140, 163, 202, 220, 234], 'progressive': [6], 'neurodegenerative': [7], 'disorder': [8], 'that': [9, 55, 81, 105, 121, 169, 223, 247, 258], 'inherited': [11], 'in': [12, 27, 40, 72, 233, 252], 'an': [13, 23, 36, 145, 180, 190], 'autosomal': [14], 'dominant': [15], 'fashion.': [16, 239], 'The': [17, 67, 151, 213], 'the': [20, 31, 41, 45, 59, 62, 82, 102, 125, 136, 196, 245, 261], 'result': [21], 'of': [22, 30, 44, 58, 61, 69, 88, 135, 139, 157, 229], 'expanded': [24], 'CAG': [25], 'repeat': [26], 'exon': [28], '1': [29], 'HD': [32, 115], 'gene,': [33], 'which': [34, 161], 'encodes': [35], 'elongated': [37, 146], 'polyglutamine': [38, 147], 'tract': [39], 'mutant': [42, 63], 'form': [43, 56], 'protein,': [46], 'huntingtin.': [47], 'Disease': [48], 'pathogenesis': [49], 'linked': [51], 'to': [52, 65, 91, 107, 111, 114, 127, 254], 'intracellular': [53, 93], 'aggregates': [54, 71, 83, 186], 'because': [57, 87], 'tendency': [60], 'protein': [64, 142, 172, 198, 222, 256], 'misfold.': [66], 'role': [68], 'huntingtin': [70, 141], 'pathology': [74], 'unclear;': [76], 'it': [77], 'has': [78], 'been': [79], 'proposed': [80], 'themselves': [84], 'are': [85, 132], 'toxic': [86], 'their': [89], 'ability': [90, 126], 'sequester': [92], 'proteins': [94], 'and': [95, 189, 237], 'disrupt': [96], 'normal': [97], 'cellular': [98], 'function.': [99], 'In': [100], 'addition,': [101], 'mechanistic': [103], 'steps': [104], 'lead': [106], 'aggregate': [108], 'formation': [109], 'appear': [110], 'be': [112], 'central': [113], 'pathology.': [116], 'We': [117, 193], 'have': [118], 'previously': [119], 'reported': [120], 'guanosine‐rich': [122], 'oligonucleotides': [123], 'with': [124, 144, 218], 'fold': [128], 'into': [129], 'G‐quartet': [131], 'effective': [133], 'inhibitors': [134], 'aggregation': [137, 173, 262], 'process': [138], 'fragment': [143], 'tract,': [148], 'Htn': [149], '1‐171(Q58).': [150], 'most': [152], 'active': [153], 'molecule': [154, 215], 'composed': [156], '20': [158], 'guanosine': [159], 'residues,': [160], 'adopt': [162], 'G‐wire': [164], 'conformation.': [165], 'Here': [166], 'we': [167], 'establish': [168], 'G20': [170, 214, 248], 'inhibits': [171], 'as': [174, 206, 208], 'judged': [175], 'by': [176, 200], 'native': [177], 'gel': [178, 182], 'electrophoresis,': [179], 'agarose': [181], 'electrophoresis': [183], 'for': [184], 'resolving': [185], '(AGERA)': [187], 'assay,': [188], 'immunoblotting': [191], 'assay.': [192], 'also': [194, 216], 'visualize': [195], 'G20‐Htn1‐171(Q58)': [197], 'complex': [199], 'using': [201], 'streptavidin‐biotin': [203], 'pull‐down': [204], 'assay': [205], 'well': [207], 'atomic': [209], 'force': [210], 'microscopy': [211], '(AFM).': [212], 'interacts': [217], 'Htn1‐171(Q23),': [219], 'fusion': [221], 'contains': [224], '23': [225], 'glutamine': [226], 'residues': [227], 'instead': [228], '58': [230], '(Q58),': [231], 'but': [232], 'more': [235], 'degenerate': [236], 'nonspecific': [238], 'Taken': [240], 'together,': [241], 'our': [242], 'data': [243], 'support': [244], 'notion': [246], 'exhibits': [249], 'some': [250], 'selectivity': [251], 'binding': [253], 'specific': [255], 'species': [257], 'assemble': [259], 'along': [260], 'pathway.': [263], '©': [264], '2009': [265], 'Wiley‐Liss,': [266], 'Inc.': [267]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165501526', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-15T13:39:43.936544', 'created_date': '2016-06-24'}