Increased glycolytic flux as an outcome of whole‐genome duplication in yeast

Name: Work Video:
Duration: 3 min 30 s
Gavin C. Conant; Kenneth H. Wolfe
{'id': 'https://openalex.org/W2165418074', 'doi': 'https://doi.org/10.1038/msb4100170', 'title': 'Increased glycolytic flux as an outcome of whole‐genome duplication in yeast', 'display_name': 'Increased glycolytic flux as an outcome of whole‐genome duplication in yeast', 'publication_year': 2007, 'publication_date': '2007-01-01', 'ids': {'openalex': 'https://openalex.org/W2165418074', 'doi': 'https://doi.org/10.1038/msb4100170', 'mag': '2165418074', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17667951', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2516368'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/msb4100170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200893805', 'display_name': 'Molecular Systems Biology', 'issn_l': '1744-4292', 'issn': ['1744-4292'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1038/msb4100170', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041114077', 'display_name': 'Gavin C. Conant', 'orcid': 'https://orcid.org/0000-0002-8677-4933'}, 'institutions': [{'id': 'https://openalex.org/I205274468', 'display_name': 'Trinity College Dublin', 'ror': 'https://ror.org/02tyrky19', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I205274468']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Gavin C Conant', 'raw_affiliation_strings': ['Smurfit Institute of Genetics, Trinity College, University of Dublin Dublin Ireland'], 'affiliations': [{'raw_affiliation_string': 'Smurfit Institute of Genetics, Trinity College, University of Dublin Dublin Ireland', 'institution_ids': ['https://openalex.org/I205274468']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058698418', 'display_name': 'Kenneth H. Wolfe', 'orcid': 'https://orcid.org/0000-0003-4992-4979'}, 'institutions': [{'id': 'https://openalex.org/I205274468', 'display_name': 'Trinity College Dublin', 'ror': 'https://ror.org/02tyrky19', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I205274468']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Kenneth H Wolfe', 'raw_affiliation_strings': ['Smurfit Institute of Genetics, Trinity College, University of Dublin Dublin Ireland'], 'affiliations': [{'raw_affiliation_string': 'Smurfit Institute of Genetics, Trinity College, University of Dublin Dublin Ireland', 'institution_ids': ['https://openalex.org/I205274468']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'apc_paid': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'fwci': 7.001, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 213, 'citation_normalized_percentile': {'value': 0.937423, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '3', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10303', 'display_name': 'Photosynthetic Processes and Mechanisms', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10171', 'display_name': 'Biofuel production and bioconversion', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8691387}, {'id': 'https://openalex.org/C7602840', 'wikidata': 'https://www.wikidata.org/wiki/Q746284', 'display_name': 'Gene duplication', 'level': 3, 'score': 0.63223577}, {'id': 'https://openalex.org/C68709404', 'wikidata': 'https://www.wikidata.org/wiki/Q1134475', 'display_name': 'Flux (metallurgy)', 'level': 2, 'score': 0.51038665}, {'id': 'https://openalex.org/C2779222958', 'wikidata': 'https://www.wikidata.org/wiki/Q45422', 'display_name': 'Yeast', 'level': 2, 'score': 0.50411975}, {'id': 'https://openalex.org/C20251656', 'wikidata': 'https://www.wikidata.org/wiki/Q162643', 'display_name': 'Glycolysis', 'level': 3, 'score': 0.49654514}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.49229634}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.4908901}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.42580014}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.29534048}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.11431432}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10730192}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C191897082', 'wikidata': 'https://www.wikidata.org/wiki/Q11467', 'display_name': 'Metallurgy', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020440', 'descriptor_name': 'Gene Duplication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016681', 'descriptor_name': 'Genome, Fungal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006019', 'descriptor_name': 'Glycolysis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002451', 'descriptor_name': 'Cell Compartmentation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004463', 'descriptor_name': 'Ecology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005285', 'descriptor_name': 'Fermentation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020131', 'descriptor_name': 'Genes, Duplicate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005800', 'descriptor_name': 'Genes, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016681', 'descriptor_name': 'Genome, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006019', 'descriptor_name': 'Glycolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009004', 'descriptor_name': 'Monosaccharide Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009004', 'descriptor_name': 'Monosaccharide Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012119', 'descriptor_name': 'Respiration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012119', 'descriptor_name': 'Respiration', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012641', 'descriptor_name': 'Selection, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/msb4100170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200893805', 'display_name': 'Molecular Systems Biology', 'issn_l': '1744-4292', 'issn': ['1744-4292'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1943425', 'pdf_url': 'https://europepmc.org/articles/pmc1943425?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2262/40525', 'pdf_url': 'http://www.tara.tcd.ie/bitstream/handle/2262/40525/Increased%20glycolytic%20flux.pdf?sequence=1&isAllowed=y', 'source': {'id': 'https://openalex.org/S4306400033', 'display_name': 'Arrow@dit (Dublin Institute of Technology)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I115570527', 'host_organization_name': 'Dublin Institute of Technology', 'host_organization_lineage': ['https://openalex.org/I115570527'], 'host_organization_lineage_names': ['Dublin Institute of Technology'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1943425', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17667951', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/msb4100170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200893805', 'display_name': 'Molecular Systems Biology', 'issn_l': '1744-4292', 'issn': ['1744-4292'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 90, 'referenced_works': ['https://openalex.org/W1482486111', 'https://openalex.org/W1495660511', 'https://openalex.org/W1535354154', 'https://openalex.org/W1545213125', 'https://openalex.org/W1547033864', 'https://openalex.org/W1550716269', 'https://openalex.org/W1572652548', 'https://openalex.org/W1578038611', 'https://openalex.org/W1641544182', 'https://openalex.org/W1804531429', 'https://openalex.org/W1873506857', 'https://openalex.org/W1887746592', 'https://openalex.org/W1917958372', 'https://openalex.org/W1964612763', 'https://openalex.org/W1966324534', 'https://openalex.org/W1967028961', 'https://openalex.org/W1970070225', 'https://openalex.org/W1972332616', 'https://openalex.org/W1983811433', 'https://openalex.org/W1988608160', 'https://openalex.org/W1995043054', 'https://openalex.org/W1996152576', 'https://openalex.org/W1997088865', 'https://openalex.org/W1997945704', 'https://openalex.org/W1998447705', 'https://openalex.org/W2000047924', 'https://openalex.org/W2000902397', 'https://openalex.org/W2002133791', 'https://openalex.org/W2006873092', 'https://openalex.org/W2016140326', 'https://openalex.org/W2025474873', 'https://openalex.org/W2034826900', 'https://openalex.org/W2035601596', 'https://openalex.org/W2036573675', 'https://openalex.org/W2039642352', 'https://openalex.org/W2043440339', 'https://openalex.org/W2044720815', 'https://openalex.org/W2044898452', 'https://openalex.org/W2045790079', 'https://openalex.org/W2046250502', 'https://openalex.org/W2046761353', 'https://openalex.org/W2047195788', 'https://openalex.org/W2048182456', 'https://openalex.org/W2048202808', 'https://openalex.org/W2048522870', 'https://openalex.org/W2054719673', 'https://openalex.org/W2057868912', 'https://openalex.org/W2061507735', 'https://openalex.org/W2066073247', 'https://openalex.org/W2068872007', 'https://openalex.org/W2069124186', 'https://openalex.org/W2075960069', 'https://openalex.org/W2078134912', 'https://openalex.org/W2081933515', 'https://openalex.org/W2091735184', 'https://openalex.org/W2091902964', 'https://openalex.org/W2092265987', 'https://openalex.org/W2094339824', 'https://openalex.org/W2100752201', 'https://openalex.org/W2103017472', 'https://openalex.org/W2103218649', 'https://openalex.org/W2104296952', 'https://openalex.org/W2116585979', 'https://openalex.org/W2120667911', 'https://openalex.org/W2123077816', 'https://openalex.org/W2130000047', 'https://openalex.org/W2135123683', 'https://openalex.org/W2135998024', 'https://openalex.org/W2137828458', 'https://openalex.org/W2140510166', 'https://openalex.org/W2142750990', 'https://openalex.org/W2143157299', 'https://openalex.org/W2144001310', 'https://openalex.org/W2144252459', 'https://openalex.org/W2144283613', 'https://openalex.org/W2147892681', 'https://openalex.org/W2150496507', 'https://openalex.org/W2152362114', 'https://openalex.org/W2153770183', 'https://openalex.org/W2159137674', 'https://openalex.org/W2163192189', 'https://openalex.org/W2163846513', 'https://openalex.org/W2163949203', 'https://openalex.org/W2168738353', 'https://openalex.org/W2169805130', 'https://openalex.org/W2170985321', 'https://openalex.org/W2171671247', 'https://openalex.org/W2173520478', 'https://openalex.org/W4229487902', 'https://openalex.org/W91518616'], 'related_works': ['https://openalex.org/W4388014327', 'https://openalex.org/W4328050637', 'https://openalex.org/W4240624121', 'https://openalex.org/W2776829638', 'https://openalex.org/W261727187', 'https://openalex.org/W2367076742', 'https://openalex.org/W2349742942', 'https://openalex.org/W2115382138', 'https://openalex.org/W2064495883', 'https://openalex.org/W1883409887'], 'abstract_inverted_index': {'Article31': [0], 'July': [1, 181], '2007Open': [2], 'Access': [3], 'Increased': [4, 170], 'glycolytic': [5, 171, 247, 293, 505, 550, 731, 810, 1129, 1876, 1963, 2448, 2573, 2609, 3101, 3402, 3500, 3884, 4440], 'flux': [6, 172, 595, 740, 1968, 2140, 2304, 2317, 2648, 2864, 2873, 3636, 4071, 4139, 4152, 4161, 4274, 4324, 4416], 'as': [7, 173, 397, 509, 906, 1693, 2009, 2099, 2283, 2420, 2433, 2703, 2767, 2780, 2911, 2964, 3140, 3282, 3354, 3362, 3464, 3682, 3718, 3723, 3993, 4027, 4132, 4134, 4168, 4454], 'an': [8, 174, 252, 258, 342, 376, 398, 495, 863, 920, 925, 1004, 1794, 1819, 1903, 2128, 2142, 2326, 2412, 2650, 2678, 2704, 2902, 2957, 3431, 3541, 3955, 4460], 'outcome': [9, 175], 'of': [10, 25, 30, 49, 54, 75, 80, 99, 104, 127, 132, 140, 143, 176, 190, 245, 260, 269, 277, 308, 365, 383, 388, 417, 427, 449, 462, 482, 499, 514, 530, 571, 605, 616, 631, 637, 646, 655, 660, 663, 682, 697, 714, 719, 747, 759, 764, 769, 788, 793, 799, 809, 816, 849, 851, 856, 858, 865, 888, 950, 958, 981, 986, 993, 1014, 1053, 1065, 1113, 1156, 1221, 1243, 1246, 1270, 1276, 1310, 1342, 1372, 1399, 1427, 1583, 1630, 1684, 1697, 1712, 1735, 1771, 1796, 1838, 1864, 1867, 1875, 1889, 1985, 2063, 2087, 2145, 2194, 2207, 2212, 2230, 2257, 2271, 2280, 2285, 2370, 2392, 2425, 2431, 2437, 2468, 2571, 2608, 2655, 2661, 2681, 2716, 2789, 2796, 2820, 2842, 2847, 2892, 2901, 2905, 2943, 2953, 2994, 3004, 3016, 3082, 3092, 3100, 3130, 3136, 3148, 3165, 3169, 3172, 3186, 3194, 3253, 3285, 3300, 3322, 3352, 3375, 3378, 3385, 3408, 3438, 3476, 3513, 3570, 3580, 3593, 3656, 3661, 3672, 3690, 3710, 3760, 3765, 3773, 3779, 3852, 3878, 3883, 3904, 3912, 3979, 3997, 4003, 4011, 4042, 4051, 4091, 4096, 4111, 4126, 4150, 4171, 4177, 4190, 4214, 4220, 4247, 4253, 4264, 4310, 4322, 4332, 4338, 4344, 4362, 4370, 4375, 4379, 4401, 4430, 4466, 4493, 4507, 4525, 4533, 4537], 'whole-genome': [11, 177, 216, 960, 1442], 'duplication': [12, 178, 217, 392, 961, 1048, 1345, 2150, 2162, 3154, 3579, 3592], 'in': [13, 179, 285, 330, 443, 454, 470, 478, 486, 503, 537, 548, 559, 563, 574, 582, 587, 618, 628, 670, 679, 699, 730, 915, 924, 963, 1193, 1208, 1218, 1261, 1298, 1307, 1336, 1403, 1448, 1452, 1455, 1522, 1544, 1551, 1559, 1564, 1590, 1640, 1707, 1774, 1784, 1801, 1880, 1897, 1908, 1943, 1954, 1987, 2000, 2036, 2058, 2084, 2095, 2102, 2125, 2154, 2204, 2221, 2275, 2277, 2309, 2329, 2353, 2372, 2414, 2435, 2452, 2524, 2534, 2543, 2567, 2576, 2597, 2631, 2643, 2652, 2726, 2744, 2759, 2771, 2784, 2935, 2992, 3021, 3104, 3133, 3177, 3183, 3231, 3250, 3276, 3295, 3305, 3332, 3365, 3389, 3396, 3415, 3456, 3467, 3480, 3530, 3568, 3599, 3628, 3631, 3649, 3694, 3739, 3770, 3937, 4030, 4062, 4076, 4084, 4102, 4108, 4114, 4119, 4137, 4206, 4224, 4228, 4295, 4348, 4395, 4447, 4451, 4463, 4480, 4499, 4513, 4522], 'yeast': [14, 667, 800, 952, 969, 1458, 1671, 1715, 1856, 1918, 2155, 2581, 2692, 3149, 3565, 3774, 3871, 4526], 'Gavin': [15, 20, 65, 70, 117], 'C': [16, 21, 66, 71, 118], 'Conant': [17, 22, 67, 72, 119], 'Corresponding': [18, 68], 'Author': [19, 69, 115], 'Smurfit': [23, 47, 73, 97, 138], 'Institute': [24, 48, 74, 98, 126, 139], 'Genetics,': [26, 50, 76, 100, 128, 141], 'Trinity': [27, 51, 77, 101, 129, 145], 'College,': [28, 52, 78, 102, 130, 146], 'University': [29, 53, 79, 103, 131, 142], 'Dublin,': [31, 32, 55, 56, 81, 82, 105, 106, 133, 134, 144], 'Ireland': [33, 57, 83, 107, 135], 'Search': [34, 58, 84, 108], 'for': [35, 59, 85, 109, 167, 233, 266, 289, 546, 613, 620, 634, 832, 1150, 1377, 1471, 1687, 1768, 1906, 1977, 2228, 2382, 2486, 2489, 2516, 2521, 2720, 2778, 2802, 2885, 3030, 3077, 3094, 3434, 3509, 3611, 3702, 3757, 3954, 4022, 4123], 'more': [36, 60, 86, 110, 446, 554, 635, 657, 689, 883, 1930, 2079, 2092, 2889, 3045, 3412, 3495, 4068], 'papers': [37, 61, 87, 111], 'by': [38, 62, 88, 112, 320, 494, 534, 836, 930, 939, 1033, 1119, 1419, 1434, 1493, 1680, 1959, 2061, 2114, 2148, 2187, 2402, 2710, 3125, 3142, 3290, 3419, 3822, 3841, 4015, 4088, 4390, 4426, 4459], 'this': [39, 63, 89, 113, 168, 309, 614, 804, 1066, 1137, 1235, 1708, 1804, 1811, 1827, 1895, 1917, 2213, 2269, 2481, 2989, 3447, 3481, 3533, 3730, 3829, 3848, 4333, 4421, 4469], 'author': [40, 64, 90, 114], 'Kenneth': [41, 44, 91, 94, 122], 'H': [42, 45, 92, 95, 123], 'Wolfe': [43, 46, 93, 96], 'Information': [116], '1': [120, 152, 157, 3161], 'and': [121, 193, 325, 374, 404, 702, 727, 757, 766, 903, 973, 1022, 1057, 1082, 1088, 1100, 1145, 1166, 1231, 1273, 1288, 1334, 1409, 1466, 1475, 1532, 1539, 1547, 1549, 1578, 1586, 1614, 1633, 1637, 1646, 1719, 1739, 1780, 1825, 1891, 1935, 2019, 2032, 2043, 2141, 2184, 2235, 2337, 2423, 2503, 2575, 2600, 2611, 2618, 2627, 2657, 2735, 2757, 2805, 2827, 2838, 2872, 2984, 3055, 3059, 3073, 3080, 3156, 3190, 3216, 3220, 3263, 3311, 3341, 3517, 3558, 3678, 3824, 3843, 3862, 3921, 3982, 4000, 4024, 4082, 4174, 4184, 4198, 4227, 4304, 4340, 4486, 4490], 'Wolfe1': [124], '1Smurfit': [125], '*Corresponding': [136], 'author.': [137], 'Dublin': [147], '2,': [148], 'Ireland.': [149], 'Tel.:': [150], '+353': [151, 156], '896': [153], '1288;': [154], 'Fax:': [155], '679': [158], '8558;': [159], 'E-mail:': [160], '[email protected]': [161], 'Molecular': [162], 'Systems': [163], 'Biology': [164], '(2007)3:129https://doi.org/10.1038/msb4100170': [165], 'Correction(s)': [166], 'article': [169, 191], 'yeast01': [180], '2008': [182], 'Synopsis': [183, 390], 'Introduction': [184, 948], 'Results': [185, 3062], 'Discussion': [186], 'AcknowledgementsSupporting': [187], 'InformationReferencesPDFDownload': [188], 'PDF': [189], 'text': [192], 'main': [194], 'figures.': [195], 'Metrics108MetricsTotal': [196], 'downloads1,826Last': [197], '6': [198, 201], 'Months110Total': [199], 'citations108Last': [200], 'Months3View': [202], 'all': [203, 1747, 2466, 3359, 3451, 3709], 'metrics': [204], 'ToolsAdd': [205], 'to': [206, 223, 257, 313, 380, 401, 423, 511, 556, 590, 601, 653, 674, 677, 707, 802, 912, 917, 1010, 1038, 1044, 1078, 1092, 1124, 1163, 1198, 1212, 1252, 1283, 1285, 1290, 1302, 1362, 1388, 1566, 1588, 1600, 1649, 1674, 1727, 1742, 1854, 1902, 1927, 1992, 1997, 2006, 2054, 2119, 2131, 2166, 2201, 2267, 2293, 2315, 2342, 2349, 2385, 2398, 2506, 2540, 2645, 2699, 2724, 2764, 2836, 2862, 2913, 2940, 2960, 2972, 2975, 3013, 3043, 3068, 3086, 3114, 3122, 3146, 3371, 3486, 3549, 3576, 3605, 3633, 3736, 4040, 4116, 4159, 4179, 4202, 4204, 4249, 4272, 4282, 4346, 4433], 'favoritesDownload': [207], 'CitationsTrack': [208], 'CitationsPermissions': [209], 'ShareFacebookTwitterLinked': [210], 'InMendeleyWechatReddit': [211], 'Figures': [212], '&': [213], 'Info': [214], 'After': [215, 517], '(WGD),': [218], 'deletions': [219], 'return': [220], 'most': [221, 484, 983, 1158], 'loci': [222, 228], 'single': [224, 2065], 'copy.': [225], 'However,': [226, 540, 860, 2171, 2665, 2946, 3681, 4468], 'duplicate': [227, 500, 520, 560, 588, 629, 1115, 1802, 1865, 2178, 2258, 3105, 3181, 3197, 3226, 3259, 3277, 3303, 3327, 3387, 3436], 'may': [229, 432, 651, 734, 840, 894, 1146, 1702, 2427, 2497, 2694, 4496], 'survive': [230, 536, 3497], 'through': [231, 303, 741, 1366, 1969, 2305, 2318, 2865, 2874, 2979, 3637, 3860, 4072, 4153, 4162, 4417], 'selection': [232, 339, 619, 1138, 1686, 2025, 3093, 3756], 'increased': [234, 242, 361, 405, 712, 737, 1023, 1872, 1904, 2143, 2231, 2301, 2492, 2508, 2517, 2612, 2903, 3635, 3758, 4428], 'dosage.': [235], 'Here,': [236, 1041], 'we': [237, 541, 608, 773, 825, 861, 1042, 1813, 1859, 1883, 1914, 1949, 2215, 3162, 3344, 3449, 3666, 3686, 3907, 4353], 'show': [238, 358, 542, 2604, 3554], 'how': [239, 919, 1835, 3896, 4358], 'the': [240, 267, 270, 275, 282, 290, 381, 386, 414, 421, 455, 471, 483, 504, 512, 515, 531, 549, 564, 572, 575, 638, 656, 661, 680, 687, 717, 720, 725, 738, 755, 760, 762, 767, 770, 786, 807, 813, 828, 844, 866, 889, 898, 900, 956, 964, 967, 982, 991, 1012, 1046, 1050, 1054, 1111, 1120, 1134, 1143, 1148, 1154, 1169, 1177, 1219, 1268, 1286, 1295, 1308, 1313, 1316, 1340, 1348, 1390, 1410, 1472, 1494, 1503, 1528, 1540, 1594, 1608, 1615, 1626, 1647, 1670, 1721, 1725, 1733, 1740, 1753, 1816, 1836, 1855, 1862, 1873, 1886, 1909, 1946, 2085, 2117, 2177, 2192, 2205, 2286, 2294, 2302, 2322, 2335, 2368, 2373, 2383, 2389, 2393, 2403, 2421, 2429, 2445, 2455, 2469, 2568, 2572, 2577, 2598, 2638, 2653, 2658, 2662, 2682, 2727, 2730, 2741, 2768, 2839, 2899, 2906, 2941, 2951, 2995, 3017, 3070, 3123, 3152, 3166, 3184, 3187, 3201, 3241, 3257, 3271, 3279, 3283, 3286, 3298, 3323, 3333, 3350, 3373, 3376, 3379, 3383, 3397, 3406, 3468, 3474, 3487, 3491, 3499, 3526, 3591, 3613, 3624, 3629, 3650, 3654, 3662, 3688, 3711, 3724, 3748, 3857, 3870, 3876, 3888, 3902, 3925, 3935, 3965, 3984, 3994, 3998, 4001, 4004, 4009, 4017, 4049, 4070, 4073, 4094, 4109, 4120, 4124, 4135, 4141, 4151, 4160, 4175, 4191, 4217, 4221, 4232, 4235, 4258, 4262, 4265, 4268, 4273, 4278, 4291, 4300, 4307, 4320, 4330, 4336, 4342, 4349, 4359, 4367, 4376, 4380, 4398, 4402, 4411, 4427, 4464, 4478, 4488, 4514, 4523, 4531, 4534], 'WGD': [241, 469, 535, 726, 776, 901, 988, 1073, 1121, 1144, 1287, 1349, 1445, 1581, 1657, 1701, 1722, 1754, 1817, 1871, 2115, 2198, 2250, 3107, 3124, 3175, 3336, 3386, 3478, 3625, 3749, 3879, 4012], 'copy': [243, 1454, 2390], 'number': [244, 2391, 2422, 3689], 'some': [246, 1114, 1275, 1289, 2405, 2697, 3081], 'genes': [248, 280, 521, 544, 562, 573, 580, 625, 1332, 1477, 1799, 1869, 2179, 2220, 2259, 2531, 2610, 3102, 3273, 3304, 3388, 3437, 3454, 3693, 3722, 3782], 'could': [249, 3424, 3818, 3837, 4423], 'have': [250, 420, 591, 705, 736, 778, 895, 954, 1007, 1070, 1303, 1601, 1703, 2116, 2225, 2243, 2357, 2399, 2410, 2695, 3229, 3520, 3573, 3714, 3944, 4298], 'conferred': [251, 999, 2919], 'almost': [253, 343], 'immediate': [254, 995], 'selective': [255, 892, 996, 1921, 2921, 3040, 3597], 'advantage': [256, 302, 367, 880, 893, 997, 1005, 1922, 2922, 2990, 3041, 3598], 'ancestor': [259, 3872], 'Saccharomyces': [261, 970, 1778, 1781, 3212, 3217, 3814, 3835], 'cerevisiae,': [262, 1461, 2887, 3211], 'providing': [263], 'a': [264, 300, 459, 464, 468, 602, 632, 709, 744, 780, 870, 878, 882, 931, 936, 944, 959, 1034, 1185, 1244, 1305, 1343, 1506, 1681, 1705, 1736, 1763, 1831, 1920, 1970, 1974, 1982, 2051, 2064, 2202, 2253, 2514, 2707, 2750, 2781, 2888, 2920, 3014, 3039, 3128, 3251, 3420, 3439, 3555, 3596, 3669, 3683, 3811, 3949, 3970, 4059, 4089, 4169, 4240, 4243, 4250, 4529], 'rationale': [265], 'success': [268], 'WGD.': [271, 389, 721, 837, 1857, 2188, 3444], 'We': [272, 356, 457, 722, 1107, 1131, 1846, 2189, 2242, 2332, 3472, 3932, 4007, 4288, 4328], 'propose': [273, 1814, 1847, 1884, 1915, 2333], 'that': [274, 360, 413, 543, 584, 607, 671, 724, 775, 792, 827, 1072, 1110, 1136, 1209, 1248, 1509, 1512, 1554, 1558, 1669, 1700, 1724, 1815, 1826, 1861, 1885, 1894, 1916, 2023, 2033, 2050, 2081, 2161, 2172, 2191, 2217, 2247, 2334, 2351, 2447, 2459, 2480, 2562, 2625, 2637, 2671, 2688, 2791, 2801, 2931, 2950, 2988, 2997, 3118, 3127, 3144, 3192, 3224, 3244, 3270, 3320, 3368, 3392, 3426, 3522, 3540, 3590, 3601, 3641, 3729, 3746, 3873, 3942, 3968, 4293, 4352, 4435], 'loss': [276, 502, 1863, 1961, 2256, 2273], 'other': [278, 1504, 1514, 1585, 1868, 1938, 3334, 3398], 'redundant': [279], 'throughout': [281], 'genome': [283, 565, 1047, 2195, 2395, 3071, 3145, 3153, 3235, 3287], 'resulted': [284, 2274, 3945], 'incremental': [286], 'dosage': [287, 332, 338, 1824, 1828, 2233, 2493, 2518, 2937], 'increases': [288, 812, 4087, 4414, 4456], 'surviving': [291, 1800, 2295, 3477, 3489], 'duplicated': [292, 2219, 3331, 3744], 'genes.': [294, 1431], 'This': [295, 643, 666, 838, 891, 1239, 1525, 3587], 'increase': [296, 1896, 1967, 2007, 2055, 2083, 2316, 2328, 2413, 2499, 2533, 2651, 4037, 4061, 4443, 4446, 4479], 'gave': [297, 1900], 'post-WGD': [298, 336, 1035, 1775, 1839, 3651, 3677, 3712], 'yeasts': [299, 1641, 1751, 1776, 1786, 1840, 1939, 2962], 'growth': [301, 1256, 1689, 2030, 2056, 2538, 2542, 3608], 'rapid': [304, 1688, 2255, 2890], 'glucose': [305, 369, 676, 1080, 1162, 1195, 1214, 1259, 1365, 1517, 1567, 1612, 1651, 1852, 1929, 1941, 2893, 2977, 3005, 3571, 3620], 'fermentation;': [306], 'one': [307, 481, 654, 885, 2012, 3237], "lineage's": [310], 'many': [311, 519, 751, 3355, 3660, 3719], 'adaptations': [312, 1247, 1279], 'glucose-rich': [314], 'environments.': [315], 'Our': [316, 489], 'hypothesis': [317, 1953, 3269, 3867], 'is': [318, 364, 480, 645, 668, 909, 990, 1183, 1188, 1196, 1206, 1241, 1260, 1374, 1386, 1478, 1491, 1518, 1520, 1792, 1973, 2047, 2077, 2265, 2378, 2396, 2722, 2740, 2798, 2844, 2861, 2948, 3112, 3288, 3404, 3417, 3525, 3732, 3825, 3868, 3976, 4234, 4260, 4280, 4436, 4457, 4472, 4484, 4518], 'supported': [319], 'data': [321, 3075, 3658], 'from': [322, 335, 434, 1380, 1441, 1480, 1803, 2494, 2519, 3339, 3659, 3828, 3834, 3847, 3946, 4038, 4242], 'enzyme': [323, 732, 1898, 1964, 1988, 2066, 2126, 2299, 2354, 2752, 3853, 3898, 3956, 3980, 4020, 4035, 4097, 4237, 4441], 'kinetics': [324, 768, 1888, 4309, 4361], 'comparative': [326, 1271], 'genomics.': [327], 'Because': [328, 743], 'changes': [329, 729, 1986, 1999, 2094, 2124, 2276, 2308, 2352, 2934, 3855, 4294], 'gene': [331, 501, 621, 1116, 1297, 1344, 1357, 1384, 1421, 1562, 1823, 1960, 1994, 2001, 2034, 2096, 2111, 2149, 2232, 2272, 2311, 2936, 3116, 3138, 3198, 3227, 3768], 'follow': [333, 3372], 'directly': [334], 'deletions,': [337], 'can': [340, 927, 942, 1280, 2039, 2163, 3238, 3345, 4387], 'confer': [341], 'instantaneous': [344], 'benefit': [345], 'after': [346, 467, 507, 1142, 1291, 1870, 2014, 2249, 2649, 2677, 3443], 'WGD,': [347, 508, 518, 2404, 2691], 'unlike': [348, 2376], 'neofunctionalization': [349], 'or': [350, 451, 1996, 2380, 3411], 'subfunctionalization,': [351], 'which': [352, 940, 1488, 2776, 2961, 3612, 3975], 'require': [353, 2091], 'specific': [354], 'mutations.': [355], 'also': [357, 410, 1346, 1655, 1761, 1793, 2244, 2462, 2532, 3330, 3394, 4437], 'theoretically': [359], 'fermentative': [362, 1186, 2336, 2578, 2585, 4157], 'capacity': [363, 3548], 'greatest': [366], 'when': [368, 1258, 1516, 1940, 3026, 4275, 4439], 'resources': [370, 3010], 'are': [371, 552, 626, 1339, 1417, 1450, 1580, 1635, 1746, 2346, 2450, 2472, 2554, 3011, 3037, 3204, 3243, 3329, 3363, 3393, 3602, 3615, 3844, 4186, 4200, 4354, 4373], 'both': [372, 1717, 2605, 4476], 'large': [373, 567], 'dense,': [375], 'observation': [377, 3588], 'potentially': [378], 'related': [379, 703, 1123], 'appearance': [382, 2952], 'angiosperms': [384, 2955], 'around': [385, 716], 'time': [387, 718, 3877], 'Gene': [391, 3457, 3460], 'has': [393, 409, 877, 1677, 2151, 3741], 'long': [394, 1682], 'been': [395, 411, 897, 1008, 1678, 2152, 2226, 2400, 3574], 'recognized': [396, 412], 'important': [399, 921, 1820], 'route': [400, 2507, 2646], 'evolutionary': [402, 1055], 'novelty': [403], 'organismal': [406], 'complexity.': [407], 'It': [408, 2076, 2264, 2633, 2685], 'different': [415, 497], 'scales': [416], 'possible': [418, 3113], 'duplications': [419, 1995], 'potential': [422, 460, 611, 2118], 'generate': [424, 943, 1743], 'differing': [425, 4308], 'kinds': [426], 'novel': [428], 'adaptations.': [429], 'New': [430], 'proteins': [431, 639, 1542, 2407], 'evolve': [433, 2040], 'single-gene': [435, 2182], 'duplications,': [436, 439], 'while': [437, 1382, 2746], 'larger': [438, 1051], 'including': [440, 754, 966, 2753], 'WGDs,': [441], 'can,': [442], 'addition,': [444], 'allow': [445, 1249, 1359, 2504, 3634], 'global': [447, 465, 2093], 'restructuring': [448], 'regulatory': [450, 1507, 4391], 'metabolic': [452, 1024, 1628, 1971, 2169, 2330, 2438, 3074, 3096, 3938, 4053], 'networks': [453], 'organism.': [456], 'describe': [458], 'example': [461, 864, 934], 'such': [463, 525, 1692, 2098, 2343, 2419, 2495, 2963, 3095, 3246, 3992], 'change': [466, 923, 1829, 3901, 3936, 4136, 4241], "bakers'": [472, 664, 829, 968], 'yeast,': [473], 'S.': [474, 538, 700, 1075, 1204, 1250, 1299, 1337, 1360, 1404, 1460, 1462, 1467, 1552, 1596, 1675, 1842, 2059, 2222, 2544, 2592, 2717, 2886, 2944, 2965, 3078, 3178, 3232, 3306, 3325, 3390, 3452, 3542, 3783, 3787, 3795, 3803, 3890, 3913], 'cerevisiae.': [475, 539, 2945, 3891], 'The': [476, 1329, 1354, 1370, 1444, 1485, 2787, 2858, 2923, 3063, 3268], 'pathway': [477, 506, 551, 576, 1187, 1972, 2579, 3369], 'question': [479, 992], 'central': [485], 'eukaryotes:': [487], 'glycolysis.': [488, 742, 3531], 'analysis': [490, 2512], 'was': [491, 834, 1122, 1139, 1925, 1942, 2069, 2252, 2291, 2321, 3626], 'initially': [492], 'prompted': [493], 'apparently': [496, 688], 'pattern': [498, 615, 3374], 'compared': [510, 1037, 3473], 'remainder': [513, 3377], 'genome.': [516, 3380], 'were': [522, 585, 2313, 2938, 2967, 3274, 3370], 'lost': [523], 'rapidly,': [524], 'that,': [526, 1192, 3164], 'today,': [527], 'only': [528, 3562, 3733], '10%': [529], 'duplicates': [532, 2183, 2185, 2520, 3117, 3131, 3176, 3356, 3403, 3413, 3479, 3496], 'created': [533, 1118], 'coding': [545], 'enzymes': [547, 771, 811, 1428, 1439, 1629, 1877, 2449, 2471, 2496, 2566, 2640, 2728, 3255, 3485, 3501, 3885, 4313, 4365, 4382, 4404], 'significantly': [553], 'like': [555], 'be': [557, 928, 1147, 1281, 2004, 2484, 2642, 2896, 3349, 3820, 3839, 4388, 4406, 4424, 4498], 'retained': [558, 3103], 'than': [561, 596, 685, 790, 1783, 1932, 2488, 2800, 2846, 3006, 3382, 3886], 'at': [566, 2729, 2868, 2877, 3038, 3278, 3646, 3715, 3875], '(with': [568], 'approximately': [569], '45%': [570], 'preserved).': [577], 'Moreover,': [578, 2560, 2813, 3318, 3564], 'those': [579, 2100, 3147, 4385], 'involved': [581, 3466], 'glycolysis': [583, 606, 2208, 2487, 2525, 2656, 3272, 3366, 3416, 3484, 3492, 4014, 4023, 4077, 4127], 'preserved': [586, 1451, 3205, 3275, 3357, 3395, 3414], 'tend': [589], 'greater': [592, 845, 2845], 'impact': [593, 1821, 2360], 'on': [594, 750, 785, 791, 1690, 1730, 1822, 1834, 2361, 2367, 2614, 3856, 3960, 3990, 4013, 4216, 4277, 4299, 4335, 4341], 'their': [597, 1125, 2168, 2500, 2552, 2785, 2973, 3044, 3120, 3618, 4031, 4043, 4194], 'non-duplicated': [598], 'counterparts,': [599], 'according': [600], 'mathematical': [603], 'model': [604], 'adapt.': [609], 'One': [610, 980, 3423, 3812], 'explanation': [612], 'preservation': [617, 1112], 'dosage,': [622], 'whereby': [623], 'certain': [624], 'maintained': [627, 2227], 'because': [630, 649, 1923, 2388, 2551, 4477, 4487], 'requirement': [633], 'copies': [636, 1866, 2467], 'they': [640, 3089], 'code': [641], 'for.': [642], 'possibility': [644, 839, 1135], 'particular': [647, 2933, 3440, 3740], 'interest': [648], 'it': [650, 672, 998, 1210, 1924, 2046, 2947, 3111, 3639], 'relate': [652], 'intriguing': [658], 'features': [659], 'physiology': [662], 'yeast.': [665, 1912, 2632], 'unusual': [669, 1207], 'prefers': [673, 1211], 'ferment': [675, 1213, 1650, 2675], 'ethanol': [678, 1199, 1216, 1379, 1772], 'presence': [681, 957, 1155, 1220, 1734], 'oxygen': [683, 765, 1182, 1222, 2371], 'rather': [684], 'using': [686, 1168], 'efficient': [690, 884, 3046], 'respiratory': [691, 2338, 2362, 2406, 2558, 2615, 2663, 2683, 4166], 'pathways.': [692], 'Interestingly,': [693], 'several': [694, 796, 951, 2218, 2347, 2522, 2565, 3742, 4052], 'previous': [695], 'studies': [696, 2105, 2436], 'fermentation': [698, 715, 833, 1367, 1408, 1632, 1890, 1907, 2306, 2628, 2639, 2702, 2721, 2910, 2917, 2980, 2998, 3861, 4026, 4229, 4510], 'cerevisiae': [701, 971, 1205, 1251, 1300, 1338, 1361, 1597, 1676, 2060, 2223, 2545, 2593, 2966, 3079, 3179, 3233, 3307, 3326, 3391, 3453, 3543, 3738, 3784, 3914], 'species': [704, 1318, 1716, 2693, 3150, 3208, 3337, 3361, 3400, 3663, 3713, 3772], 'seemed': [706], 'indicate': [708, 1429, 1437], 'trend': [710, 1767], 'toward': [711, 1127], 'importance': [713, 815], 'argue': [723, 774, 2190, 2268, 3425], 'consequent': [728, 2659], 'concentrations': [733, 820, 1613, 1618, 1874, 1965, 1989, 2300, 2553, 2871, 3882, 3899, 3941, 4021, 4036, 4098, 4195, 4378, 4386, 4442, 4492], 'first': [735, 2742, 2769, 2924, 3188, 3684, 3866, 3933, 3950, 4222], 'overall': [739, 2327, 3432, 4117], "cell's": [745, 2287], 'rate': [746, 787, 2086, 2430, 2654, 2822, 2891, 2918], 'respiration': [748, 789, 1311, 1634, 1892, 2365, 2626, 2734, 3863, 4225, 4508, 4517], 'depends': [749, 2366, 3989], 'complex': [752, 945, 1487], 'factors,': [753], 'size': [756], 'location': [758, 2424], 'mitochondria,': [761], 'concentration': [763, 808, 1899, 2355, 2369, 2502, 2788, 3854, 3967, 4002, 4050, 4063, 4110, 4173, 4181, 4238, 4297, 4337, 4413, 4449, 4465, 4482], 'involved,': [772], 'would': [777, 1006, 2090, 2408, 2641, 3248, 3348], 'had': [779, 1818, 1830, 1919, 2696, 3880], 'much': [781], 'less': [782, 871, 3000], 'pronounced': [783], 'effect': [784, 1738, 1833, 3557, 4292, 4422, 4471], 'fermentation.': [794, 2736], 'Indeed,': [795, 2510], 'mutant': [797], 'strains': [798, 2594], 'seem': [801, 841, 2635], 'support': [803, 2211, 3606], 'hypothesis:': [805], 'reducing': [806], 'relative': [814, 2278, 2303, 2310, 2539, 3042, 3858, 4218, 4236, 4271, 4368, 4399, 4415], 'respiration,': [817, 2432], 'increasing': [818], 'these': [819, 1277, 2037, 2122, 2622, 3195, 3427, 3695, 4311, 4363, 4494], 'decreases': [821, 4118], 'its': [822, 907, 1001, 1039, 1151, 1933, 3083], 'importance.': [823], 'Thus,': [824, 914, 2491, 2884], 'believe': [826], "yeast's": [830], 'preference': [831, 1905, 2719, 3433], 'enhanced': [835, 1074], 'counter-intuitive,': [842], 'given': [843, 3319, 4261, 4306], 'efficiency': [846], '(in': [847], 'terms': [848], 'moles': [850], 'ATP': [852, 1174, 3001], 'produced': [853, 2113, 2186], 'per': [854, 3002], 'mole': [855], 'glucose)': [857], 'respiration.': [859, 2490, 2772, 2914, 3008], 'illustrate': [862], 'well-known': [867], 'phenomenon': [868], 'where': [869], 'efficient,': [872], 'but': [873, 3047, 3610], 'faster': [874], 'growing': [875], 'population': [876, 3630], 'competitive': [879, 3022], 'over': [881, 1713, 4140, 4325], '(the': [886, 1223, 4444], "'tragedy": [887, 3015], "commons').": [890], 'even': [896, 1217, 2689, 4067], 'reason': [899, 1149], 'survived': [902, 1879, 3230], 'became': [904], 'fixed,': [905], 'survival': [908], 'otherwise': [910, 3603], 'difficult': [911, 2379], 'explain.': [913], 'addition': [916], 'suggesting': [918, 2160], 'physiological': [922], 'organism': [926, 1036], 'wrought': [929], 'duplication,': [932, 1606, 3236], 'our': [933, 3707, 3865, 4396], 'provides': [935], 'plausible': [937, 2949], 'mechanism': [938], 'evolution': [941, 2104], 'new': [946], 'adaptation.': [947], 'Analyses': [949], 'genomes': [953, 3696], 'confirmed': [955], '(WGD)': [962], 'clade': [965], '(Wolfe': [972, 1081], 'Shields,': [974, 1083], '1997;': [975, 1084, 1534], 'Kellis': [976], 'et': [977, 1018, 1029, 1062, 1096, 1104, 1201, 1227, 1264, 1322, 1326, 1351, 1394, 1482, 1536, 1569, 1574, 1620, 1643, 1659, 1663, 1756, 1788, 1807, 2073, 2107, 2157, 2239, 2261, 2441, 2476, 2527, 2547, 2588, 2667, 2810, 2831, 2851, 2855, 2881, 3051, 3315, 3536, 3584, 3917, 3929, 4209, 4502], 'al,': [978, 1019, 1030, 1063, 1097, 1105, 1202, 1228, 1265, 1323, 1327, 1352, 1395, 1537, 1570, 1575, 1621, 1644, 1660, 1664, 1757, 1789, 1808, 2074, 2108, 2158, 2240, 2262, 2442, 2477, 2528, 2548, 2589, 2811, 2832, 2852, 2856, 2882, 3052, 3316, 3585, 3918, 3930, 4210, 4503], '2004).': [979, 2241, 2986], 'puzzling': [984], 'aspects': [985], 'any': [987, 2082, 2932], 'event': [989, 1805], 'what': [994, 3240, 3347], 'upon': [1000], 'possessor.': [1002], 'Such': [1003], 'necessary': [1009], 'counteract': [1011], 'disadvantages': [1013], 'reproductive': [1015], 'isolation': [1016], '(Grieg': [1017], '2002a,': [1020], '2002b)': [1021], 'costs': [1025], '(Wagner,': [1026, 1059], '2005;': [1027, 3057], 'Gerstein': [1028], '2006)': [1031], 'experienced': [1032], 'peers.': [1040], 'try': [1043], 'place': [1045, 2644, 4512], 'into': [1049, 1215, 2181, 2909, 3895], 'picture': [1052], 'history': [1056], 'ecology': [1058], '2000;': [1060, 1324, 3919], 'Hittinger': [1061], '2004)': [1064], 'species.': [1067, 3652, 3727], 'Several': [1068, 1695], 'authors': [1069], 'speculated': [1071], "cerevisiae's": [1076, 2718], 'ability': [1077, 1648, 1726, 1741, 2698, 2974], 'metabolize': [1079, 1513], 'Wolfe,': [1085, 2236, 3157, 3221, 3342], '2004;': [1086, 1102], 'Liti': [1087], 'Louis,': [1089], '2005)': [1090], 'and/or': [1091], 'grow': [1093, 1728], 'anaerobically': [1094, 1729], '(Kwast': [1095, 2546], '2002;': [1098, 3313], 'Piškur': [1099, 1103, 2983], 'Langkjær,': [1101, 2985], '2006).': [1106, 1266, 2263, 3061], 'provide': [1108], 'evidence': [1109, 1698, 3091], 'pairs': [1117, 1426, 1446, 2112, 3182, 3199, 3228, 3247, 3328], 'contribution': [1126], 'high': [1128, 1255, 2139], 'flux.': [1130, 2363, 2509, 4327], 'further': [1132], 'consider': [1133], 'active': [1140], 'soon': [1141, 2248], 'survival.': [1152], 'In': [1153, 1810, 1945, 1980, 2210, 3024, 3159, 3704, 4419], 'oxygen,': [1157], 'eukaryotes': [1159], 'fully': [1160], 'oxidize': [1161], 'carbon': [1164, 3905], 'dioxide': [1165], 'water': [1167], 'TCA': [1170, 1411], 'cycle,': [1171], 'driving': [1172], 'mitochondrial': [1173, 2394, 2456, 4489], 'synthesis': [1175], 'with': [1176, 1315, 1607, 1718, 1750, 2028, 2138, 2454, 2583, 2595, 2823, 2834, 2898, 3033, 3297, 3545, 3706, 3924, 4056, 4357], 'accumulated': [1178], 'reduced': [1179], 'coenzymes.': [1180], 'When': [1181], 'limited,': [1184], 'used': [1189, 3908], 'instead,': [1190], 'so': [1191, 2473, 4407], 'yeasts,': [1194], 'converted': [1197], '(Pronk': [1200, 2880], '1996).': [1203, 2857, 2883], 'Crabtree': [1224, 1737, 3556], 'effect;': [1225], 'Geladé': [1226, 1535], '2003;': [1229], 'Johnston': [1230], 'Kim,': [1232], '2005),': [1233, 1645, 2045, 3343], 'despite': [1234], "pathway's": [1236], 'energetic': [1237], 'inefficiency.': [1238], 'phenotype': [1240], 'part': [1242, 2284, 2715], 'suite': [1245], 'maintain': [1253, 3174], 'very': [1254, 2254, 3546], 'rates': [1257, 1770, 2031, 2057, 2586, 3609, 3648, 3675, 3759, 3953], 'excess': [1262, 1795, 3299], '(Piškur': [1263], 'On': [1267, 1502, 4231, 4257], 'basis': [1269], 'genetics': [1272], 'genomics,': [1274], 'Crabtree-related': [1278], 'dated': [1282], 'prior': [1284], 'it.': [1292], 'For': [1293], 'instance,': [1294], 'HAP4': [1296], 'seems': [1301], 'acquired': [1304], 'role': [1306, 1706, 2515], 'regulation': [1309], 'since': [1312, 1605, 3106, 3234], 'split': [1314], 'non-WGD': [1317, 1785, 3679, 3726], 'Kluyveromyces': [1319], 'lactis': [1320, 1546, 2673, 3800], '(Blom': [1321], 'Buschlen': [1325], '2003).': [1328, 3931], 'alcohol': [1330, 1407, 2701, 4025], 'dehydrogenase': [1331, 2748, 4164], 'ADH1': [1333, 1373], 'ADH2': [1335], 'product': [1341, 1371, 1385], 'post-dating': [1347], '(Thomson': [1350, 1393], '2005).': [1353, 1396, 1790, 1809, 2529, 2620, 3158, 3222, 3317, 4504], 'two': [1355, 1595, 2774, 2925, 3961, 4092, 4187, 4269, 4312, 4364, 4381, 4403], 'resulting': [1356, 2907], 'products': [1358], 'efficiently': [1363], 'use': [1364, 1928, 2700], '(Figure': [1368, 4064], '1).': [1369, 3267], 'primarily': [1375], 'responsible': [1376], 'producing': [1378], 'acetaldehyde,': [1381], "ADH2's": [1383], 'optimized': [1387], 'catalyze': [1389], 'reverse': [1391], 'reaction': [1392, 1416, 2013, 2821, 3952, 3958, 3973, 3986, 3999, 4075, 4223], 'Figure': [1397, 2760, 3160, 3266, 4085, 4103, 4105, 4317, 4371, 4452], '1.Overview': [1398], 'three': [1400, 1435, 1848, 3335, 3399, 3725], 'catabolic': [1401], 'pathways': [1402, 1511, 2339], 'cerevisiae:': [1405], 'glycolysis,': [1406, 1631, 2319, 2464, 3170, 3638], 'cycle.': [1412], 'Enzymes': [1413, 1432], 'catalyzing': [1414, 4005], 'each': [1415, 1584, 1952], 'illustrated': [1418, 1492], 'circled': [1420], 'names.': [1422], 'Single': [1423], 'lines': [1424, 1436, 1696], 'joining': [1425], 'paralogous': [1430, 1438], 'joined': [1433], 'derived': [1440], 'duplication.': [1443, 3947], 'shown': [1447, 2246, 3521, 4450], 'red': [1449], 'double': [1453], 'four': [1456, 3207, 3360], 'extant': [1457], 'species:': [1459], 'bayanus,': [1463, 3213], 'C.': [1464, 3791], 'glabrata': [1465, 3215, 3792], 'castellii.': [1468], 'Protein': [1469], 'localization': [1470], 'CIT,': [1473], 'ADH': [1474], 'ALD': [1476], 'taken': [1479], 'Huh': [1481], 'al': [1483, 2668, 3537], '(2003).': [1484], 'multi-enzyme': [1486], 'constitutes': [1489], 'PDH': [1490, 2797, 2848, 2866, 4326], 'darker': [1495], 'blue': [1496], 'enclosure.': [1497], 'Download': [1498, 1500, 4284, 4286], 'figure': [1499, 4285], 'PowerPoint': [1501, 4287], 'hand,': [1505], 'circuit': [1508, 1526], 'represses': [1510], 'sugars': [1515], 'abundant': [1519], 'conserved': [1521], 'K.': [1523, 1545, 1591, 2672, 3799], 'lactis.': [1524, 1592], 'includes': [1527], 'MIG1': [1529], 'repressor': [1530], '(Dong': [1531], 'Dickson,': [1533], '2003)': [1538], 'glucose-sensing': [1541], '(RAG4': [1543], 'SNF3': [1548, 1577], 'RGT2': [1550, 1579], 'cerevisiae)': [1553, 1843], 'initiate': [1555], 'signal': [1556], 'cascades': [1557], 'turn': [1560], 'alter': [1561], 'expression': [1563, 2035, 2097, 2206, 2282, 2535, 2607], 'response': [1565, 4115], '(Özcan': [1568, 1619], '1996,': [1571, 1622], '1998;': [1572, 2982], 'Betina': [1573], '2001).': [1576, 1665], 'paralogs': [1582, 1598, 3769], 'orthologous': [1587], 'RAG4': [1589], 'Notably,': [1593], 'appear': [1599, 3249], 'undergone': [1602], 'functional': [1603, 3441], 'divergence': [1604], 'former': [1609], 'signaling': [1610], 'low': [1611, 2869], 'latter': [1616], 'higher': [1617, 1769, 2029, 2584, 2878, 3607, 3647], '1998).': [1623, 3586], 'Of': [1624], 'course': [1625], 'primary': [1627], 'ancient': [1636, 3258], 'widely': [1638], 'distributed': [1639], '(Blank': [1642, 1787], 'under': [1652, 2536, 2557, 3559], 'anaerobic': [1653, 2537], 'conditions': [1654, 3561, 3569], 'predates': [1656], '(Visser': [1658], '1990;': [1661], 'Møller': [1662], 'These': [1666, 2773], 'observations': [1667], 'suggest': [1668, 1699, 1860, 2624, 2930], 'lineage': [1672, 1837], 'leading': [1673], 'characterized': [1679], 'period': [1683], 'natural': [1685, 1978, 2024], 'substrates': [1691], 'glucose.': [1694, 1845], 'played': [1704], 'selection.': [1709, 1979], 'A': [1710, 2766], 'survey': [1711], '40': [1714], 'without': [1720, 3151], 'indicates': [1723], 'minimal': [1731], 'media,': [1732], 'petite': [1744], 'mutants': [1745], 'strongly': [1748], 'associated': [1749, 2897], 'possessing': [1752], '(Merico': [1755], '2007).': [1758], 'Another': [1759], 'study': [1760, 2173], 'found': [1762, 2153, 2670, 3539], 'general,': [1764, 1981], 'though': [1765], 'weak,': [1766, 4475], 'production': [1773], '(e.g.,': [1777], 'exiguus': [1779], 'servazzii)': [1782], 'There': [1791, 2345], 'energy': [1797, 3301, 3996], 'metabolism': [1798, 1853, 3036, 3302, 3915], '(Kuepfer': [1806, 2526], 'paper': [1812], 'knock-on': [1832], '(including': [1841, 3256], 'uses': [1844], 'linked': [1849], 'hypotheses': [1850, 2926, 3065], 'relating': [1851], 'First,': [1858, 2364], '(which': [1878], 'duplicate).': [1881], 'Second,': [1882, 2387], 'inherent': [1887, 4360], 'meant': [1893], 'rise': [1901], 'partially': [1910, 3734], 'polyploid': [1911], 'Finally,': [1913, 2591], 'able': [1926, 2314, 3604], 'rapidly': [1931, 2041, 2978], 'ancestors': [1934, 2942], 'hence': [1936, 3826, 3845, 4199], 'out-compete': [1937], 'excess.': [1944], 'sections': [1947], 'below,': [1948], 'briefly': [1950], 'introduce': [1951], 'turn.': [1955], 'Hypothesis': [1956, 2297, 2915, 3098, 3511, 3850, 4505], '1—WGD': [1957], 'followed': [1958], 'raised': [1962], 'To': [1966, 3445, 3892, 3948], 'challenging': [1975], 'problem': [1976], 'slow': [1983], 'succession': [1984], '(due': [1990], 'either': [1991], 'independent': [1993, 1998, 3978, 4374], 'expression)': [2002], 'will': [2003, 2674], 'required': [2005], 'flux,': [2008, 3906], '(roughly': [2010], 'speaking)': [2011], 'another': [2015], 'becomes': [2016], 'rate-limiting': [2017, 2556, 3528], '(Kacser': [2018], 'Burns,': [2020], '1973).': [2021], 'Given': [2022, 3223, 3381, 3653], 'favors': [2026], 'microorganisms': [2027], 'organisms': [2038, 2165, 3032], '(Dekel': [2042], 'Alon,': [2044], 'not': [2048, 2175, 2324, 2409, 2465, 2555, 2928, 3553, 3751, 3819, 3838, 4393, 4497], 'surprising': [2049, 2636], 'laboratory': [2052], 'attempt': [2053], 'overexpression': [2062], '(pyruvate': [2067], 'decarboxylase)': [2068], 'unsuccessful': [2070], '(van': [2071, 2849], 'Hoek': [2072], '1998a).': [2075], 'instead': [2078], 'likely': [2080], 'cell': [2088, 2384], 'division': [2089], 'seen': [2101, 2411, 2434, 3020, 3309, 3364, 4438, 4483], 'experimental': [2103, 3657], '(Ferea': [2106], '1999).': [2109, 2443], 'Duplicate': [2110], 'produce': [2120], 'precisely': [2121], 'simultaneous': [2123], 'concentrations,': [2127], 'idea': [2129], 'attributable': [2130], 'Ohno': [2132], '(1970).': [2133], 'An': [2134], 'association': [2135, 2453], 'between': [2136, 2733, 3676, 4267], 'reactions': [2137, 2523, 2616, 3168, 4125, 4270, 4302], 'frequency': [2144, 3281], 'iso-enzymes': [2146], 'formed': [2147], '(Papp': [2156], '2004),': [2159], 'help': [2164], 'adapt': [2167], 'fluxes.': [2170], 'did': [2174], 'partition': [2176], 'considered': [2180, 3934, 4099], 'process': [2193, 2270, 3470], 'shrinkage': [2196], 'following': [2197], 'eventually': [2199], 'led': [2200, 3066], 'bias': [2203], 'enzymes.': [2209, 3493], 'contention,': [2214], 'note': [2216], 'today': [2224], 'reasons': [2229, 2348], '(Seoighe': [2234], '1999;': [2237], 'Koszul': [2238], 'previously': [2245, 3109, 3308, 3909], 'there': [2251], '(Scannell': [2260], 'reasonable': [2266], 'levels': [2279, 4045], 'protein': [2281, 2288], "'energy": [2289], "budget'": [2290], 'redirected': [2292], 'duplicates.': [2296], '2—higher': [2298], 'If': [2307, 3623, 3864], 'dosages': [2312], 'why': [2320], 'result': [2323, 2860], 'simply': [2325, 3429], 'rate?': [2331], 'responded': [2340], 'differently': [2341, 2630], 'changes.': [2344, 3097], 'think': [2350], 'should': [2356, 2483, 2895, 3644], 'relatively': [2358], 'little': [2359], 'cell,': [2374], 'which,': [2375], 'glucose,': [2377, 3031], 'impossible': [2381], 'alter.': [2386], 'unlikely': [2397], 'affected': [2401], 'concentration.': [2415], 'Third,': [2416], 'spatial': [2417, 2460], 'factors': [2418, 2603, 3991], 'mitochondria': [2426, 4524, 4538], 'constrain': [2428], 'scaling': [2439, 2819], '(West': [2440], 'Although': [2444], 'fact': [2446, 2996], 'observed': [2451, 3575], 'surface': [2457, 4535], 'suggests': [2458], 'constraints': [2461], 'affect': [2463], 'requisite': [2470], 'localized': [2474], '(Brandina': [2475], '2006),': [2478], 'meaning': [2479], 'constraint': [2482], 'weaker': [2485], 'generally': [2498], 'dissolved': [2501], 'them': [2505, 3173], 'computational': [2511], 'supports': [2513], 'Glycolytic': [2530], 'aerobic': [2541, 3560], '2002),': [2549], 'presumably': [2550], 'conditions.': [2559], 'experiments': [2561], 'simultaneously': [2563], 'overexpressed': [2564], 'lower': [2569, 2799, 3881], 'half': [2570, 3971], 'chain': [2574], 'yielded': [2580], 'cells': [2582, 3566, 3614], '(Smits': [2587], '2000).': [2590], 'mutations': [2596], 'GCR1': [2599], 'GCR2': [2601], 'transcription': [2602], 'lowered': [2606], 'reliance': [2613], '(Sasaki': [2617], 'Uemura,': [2619], 'Collectively,': [2621], 'points': [2623], 'scale': [2629], 'might': [2634, 3900, 3943], 'additional': [2647], 'saturation': [2660], 'apparatus.': [2664, 2684], 'Zeeman': [2666], '(1998)': [2669], 'aerobically': [2676], 'artificial': [2679], 'block': [2680], 'thus': [2686], 'appears': [2687], 'before': [2690], 'overflow': [2705], 'pathway,': [2706], 'principle': [2708], 'suggested': [2709], 'Käppelli': [2711], '(1986).': [2712], 'At': [2713], 'least': [2714, 3716], 'due': [2723, 2971, 3735], 'differences': [2725], 'branch': [2731], 'point': [2732], 'Pyruvate': [2737], 'decarboxylase': [2738, 4155], '(PDC)': [2739], 'step': [2743, 2770, 3529], 'fermentation,': [2745], 'pyruvate': [2747, 2763, 2779, 2790, 2870, 2908, 4057, 4079, 4154, 4163, 4172, 4296, 4339, 4412], '(PDH,': [2749, 4165], 'multicomponent': [2751], 'PDA1,': [2754], 'PDB1,': [2755], 'LAT1': [2756], 'LDP1': [2758], '1)': [2761, 4086], 'converts': [2762], 'acetyl-Coenzyme': [2765], 'reactions,': [2775], 'compete': [2777, 3029], 'substrate,': [2782], 'differ': [2783], 'kinetics.': [2786], 'gives': [2792, 3969], 'half-maximal': [2793], 'activity': [2794, 2841], '(Km)': [2795], 'PDC': [2803, 2814, 2843, 2875, 4303, 4323], '(Kresze': [2804], 'Ronfit,': [2806], '1981;': [2807], 'van': [2808], 'Urk': [2809, 2850], '1989).': [2812], 'exhibits': [2815], 'cooperativity': [2816], '(super': [2817], 'linear': [2818], 'substrate': [2824, 3966], 'concentration;': [2825], 'Boiteux': [2826], 'Hess,': [2828], '1970;': [2829], 'Hübner': [2830], '1978)': [2833], 'respect': [2835], 'pyruvate,': [2837], 'maximal': [2840, 3619, 3972, 3985], '1989;': [2853], 'Pronk': [2854], 'net': [2859], 'make': [2863, 3668], 'favored': [2867, 2876], 'ones': [2879], 'consumption': [2894], 'routing': [2900], 'proportion': [2904, 3384, 3475, 3488], 'opposed': [2912], '3—increased': [2916], 'do': [2927], 'themselves': [2929], 'advantageous': [2939], 'fruit-bearing': [2954], 'opened': [2956], 'ecological': [2958], 'niche': [2959], 'particularly': [2968], 'well': [2969, 4133], 'adapted': [2970], 'consume': [2976], '(Ashburner,': [2981], 'Note': [2987, 3728, 4351], 'exists': [2991], 'spite': [2993], 'yields': [2999], 'gram': [3003], 'does': [3007, 3552, 3887], 'Glucose': [3009], 'susceptible': [3012], "commons'": [3018], 'often': [3019], 'situations.': [3023], 'particular,': [3025], 'multiple': [3027], 'genotypes': [3028], 'fast,': [3034], 'inefficient': [3035], 'slower-growing': [3048], 'competitors': [3049], '(Pfeiffer': [3050], '2001;': [3053], 'Pfeiffer': [3054], 'Schuster,': [3056], 'MacLean': [3058], 'Gudelj,': [3060], 'above': [3064], 'us': [3067], 'examine': [3069], 'sequence': [3072], 'available': [3076], 'close': [3084], 'relatives': [3085], 'see': [3087, 3506, 3699], 'if': [3088, 3367], 'showed': [3090], '1A—number': [3099], 'As': [3108, 4034, 4528], 'described,': [3110], 'identify': [3115], 'owe': [3119], 'existence': [3121], 'showing': [3126, 4058], 'pair': [3129, 3202], 'lie': [3132], 'paired': [3134], 'regions': [3135], 'shared': [3137], 'order,': [3139], 'inferred': [3141], 'comparing': [3143], '(Byrne': [3155], 'find': [3163], '10': [3167], 'five': [3171, 3193, 3410, 3771], '(two': [3180], 'case': [3185], 'reaction)': [3189], 'moreover': [3191], 'six': [3196, 3245], '(excluding': [3200], 'GPM2/GPM3)': [3203], 'across': [3206, 3358, 4093], 'examined': [3209, 3687], '(Saccharomyces': [3210], 'Candida': [3214], 'castellii;': [3218], 'Byrne': [3219, 3340], '551': [3225, 3324], 'ask': [3239, 3346], 'chances': [3242], 'group': [3252], 'thirteen': [3254], 'hexokinase,': [3260], 'phosphoglycerate': [3261], 'mutase': [3262], 'phosphofructokinase': [3264], 'enzymes;': [3265], 'same': [3280, 4142, 4192], 'reminder': [3284], 'rejected': [3289], "Fisher's": [3291, 3503], 'exact': [3292, 3504], 'test': [3293, 3446], '(P=0.0014),': [3294], 'agreement': [3296, 3705], '(Conant': [3310], 'Wagner,': [3312], 'Kuepfer': [3314], '239': [3321], '(taken': [3338], 'chance': [3351], 'seeing': [3353, 3409], 'excluding': [3401, 3483], '(239–5)/(551–6)=0.43,': [3405], 'probability': [3407], 'P=0.056': [3418], 'binomial': [3421], 'test.': [3422], 'results': [3428], 'reflect': [3430], 'retaining': [3435], 'class': [3442], 'possibility,': [3448], 'retrieved': [3450], 'classified': [3455], 'Ontology': [3458, 3461], '(The': [3459], 'Consortium,': [3462], '2000)': [3463], 'being': [3465], 'biological': [3469], "'catabolism'.": [3471], 'category': [3482], 'among': [3490, 3498], 'Significantly': [3494], '(P=0.004,': [3502], 'test,': [3505], 'Supplementary': [3507, 3700, 4047, 4315], 'methods': [3508, 3701], 'details).': [3510, 3703], '1B—distribution': [3512], 'hexose': [3514, 3523, 3581, 3642, 3673, 3691, 3720, 3766, 3780, 3816], 'transporters': [3515, 3582, 3594, 3745], 'Pritchard': [3516, 3920], 'Kell': [3518], '(2002)': [3519], 'transport': [3524, 3550, 3643, 3674, 3767, 3781], 'major': [3527], 'Supporting': [3532], 'observation,': [3534], 'Otterstedt': [3535], '(2004)': [3538], 'strain': [3544], 'limited': [3547], 'hexoses': [3551], 'respires.': [3563], 'grown': [3567], 'limitation': [3572], 'undergo': [3577], 'spontaneous': [3578], '(Brown': [3583], 'implies': [3589], 'confers': [3595], 'environments': [3600], 'operating': [3616], 'near': [3617], 'uptake': [3621], 'rates.': [3622], 'fixed': [3627], 'order': [3632], 'follows': [3640], 'occur': [3645], 'lack': [3655], 'studied': [3664, 4290], 'here,': [3665], 'cannot': [3667, 4405], 'quantitative': [3670], 'comparison': [3671], 'yeasts.': [3680], 'approximation,': [3685, 3951], 'transporter': [3692, 3721, 3817], '(Table': [3697], 'I;': [3698], 'hypothesis,': [3708], 'twice': [3717], 'difference': [3731], 'WGD—S.': [3737], 'tandemly': [3743], 'post-date': [3747], '(data': [3750], 'shown)—and': [3752], 'probably': [3753, 4473], 'reflects': [3754], 'ongoing': [3755], 'transport.': [3761], 'Table': [3762], '1.': [3763], 'Number': [3764, 3778], 'Species': [3775], 'Has': [3776], 'WGD?': [3777], 'Yes': [3785, 3789, 3793, 3797], '18': [3786], 'bayanusa': [3788], '16': [3790], '11': [3794], 'castelliib': [3796], '14': [3798], 'No': [3801, 3805, 3809], '2': [3802], 'kluyveri': [3804], '5': [3806, 3810], 'E.': [3807], 'gosspyii': [3808], 'identified': [3813], 'bayanus': [3815], 'aligned': [3821, 3840], 'GenomeHistory,': [3823, 3842], 'omitted': [3827, 3846], 'row.': [3830, 3849], 'b': [3831], 'Three': [3832], 'sequences': [3833], 'castellii': [3836], '2A—effects': [3851], 'fluxes': [3859, 4219, 4266], 'correct,': [3869], 'existed': [3874], 'modern': [3889], 'gain': [3893], 'insight': [3894], 'altered': [3897], 'patterns': [3903], 'published': [3910], 'models': [3911], '(Teusink': [3916], 'Kell,': [3922], '2002)': [3923], 'Jarnac/Jdesigner': [3926], 'package': [3927], '(Sauro': [3928], 'steady': [3939], 'state': [3940, 4246], 'catalyzed': [3957], 'depend': [3959], 'enzyme-specific': [3962], 'parameters:': [3963], 'Km,': [3964], 'rate,': [3974], 'essentially': [3977], 'concentration,': [3981], 'Vmax,': [3983], 'velocity.': [3987], 'Vmax': [3988, 4032, 4121, 4455], 'activation': [3995], 'enzyme.': [4006], 'modeled': [4008], 'effects': [4010], 'representing': [4016], 'implied': [4018], 'ancestral': [4019], 'uniform': [4028], 'reductions': [4029], 'values.': [4033], '65': [4039], '100%': [4041], 'current': [4044], '(see': [4046, 4255, 4314], 'methods),': [4048], 'intermediates': [4054], 'increases,': [4055], '17%': [4060], '2A).': [4065, 4104], 'Perhaps': [4066], 'significantly,': [4069], 'final': [4074], '(i.e.,': [4078], 'kinase,': [4080], 'CDC19': [4081], 'PYK2': [4083], 'factor': [4090], 'range': [4095, 4143], '(red': [4100], 'line': [4101], '2.(A)': [4106], 'Changes': [4107], 'key': [4112], 'metabolites': [4113], 'values': [4122], '(blue,': [4128], 'left': [4129], 'axis': [4130, 4146], 'scale),': [4131], 'PYK': [4138], '(red,': [4144], 'right': [4145], 'scale).': [4147], '(B)': [4148], 'Ratio': [4149], '(PDC,': [4156], 'pathways)': [4158], 'pathway)': [4167], 'function': [4170], 'ratio': [4176, 4263, 4321, 4334, 4343, 4429, 4532], 'NAD+': [4178, 4183, 4345, 4432, 4448, 4481], 'NADH': [4180, 4185, 4347, 4434], '(because': [4182], 'oxidation': [4188], 'states': [4189], 'molecule,': [4193], 'vary': [4196], 'inversely': [4197], 'constrained': [4201], 'sum': [4203], '8.01': [4205], 'B;': [4207], 'Theobald': [4208], '1997).': [4211], '(C)': [4212], 'Effect': [4213], 'compartmentalization': [4215], '(PDH)': [4226], '(PDC).': [4230], 'x-axis': [4233, 4279], 'modeling': [4239], 'rough': [4244], 'pre-duplication': [4245], '0.65': [4248], 'post-duplicate': [4251], 'value': [4252], '1.0': [4254], 'A).': [4256], 'y-axis': [4259], '[E]': [4276], 'equal': [4281, 4461], '1.0.': [4283], 'next': [4289], 'competing': [4301], 'PDH,': [4305], 'methods).': [4316], '2B': [4318, 4372], 'shows': [4319], 'plot': [4329], 'dependence': [4331], 'mitochondria.': [4350], 'concerned': [4355], 'here': [4356], 'differ:': [4366], 'contours': [4369], 'actual': [4377], '(so': [4383], 'although': [4384], 'changed': [4389], 'interactions': [4392], 'included': [4394], 'analysis,': [4397], 'behavior': [4400], 'easily': [4408], 'altered).': [4409], 'Increasing': [4410], 'PDC.': [4418], 'principle,': [4420], 'counteracted': [4425], 'cytosolic': [4431, 4491], 'slight': [4445], '2A': [4453], 'matched': [4458], 'decrease': [4462], 'NADH).': [4467], 'counter': [4470], 'quite': [4474], 'small': [4485], 'cofactors': [4495], 'equilibrium': [4500], '(Bunoust': [4501], '2B—compartmentalization': [4506], 'Alcoholic': [4509], 'takes': [4511], 'cytosol,': [4515], 'whereas': [4516], 'carried': [4519], 'out': [4520], 'exclusively': [4521], 'cells.': [4527], 'result,': [4530], 'area': [4536]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165418074', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 24}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2025-01-18T07:28:14.210998', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
