Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial

Name: Work Video:
Duration: 3 min 30 s
Thomas K. Waddell; Ian Chau; David Cunningham; David González; Alicia Okines; Andrew Wotherspoon; Claire Saffery; Gary Middleton; Jonathan Wadsley; David Ferry; Wasat Mansoor; Tom Crosby; Fareeda Y. Coxon; David A. Smith; Justin S. Waters; Timothy Iveson; Stephen Falk; Sarah Slater; Clare Peckitt; Yolanda Barbáchano
{'id': 'https://openalex.org/W2165411051', 'doi': 'https://doi.org/10.1016/s1470-2045(13)70096-2', 'title': 'Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial', 'display_name': 'Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial', 'publication_year': 2013, 'publication_date': '2013-04-17', 'ids': {'openalex': 'https://openalex.org/W2165411051', 'doi': 'https://doi.org/10.1016/s1470-2045(13)70096-2', 'mag': '2165411051', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23594787', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3669518'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s1470-2045(13)70096-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116900674', 'display_name': 'The Lancet Oncology', 'issn_l': '1470-2045', 'issn': ['1470-2045', '1474-5488'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3669518', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030295431', 'display_name': 'Thomas K. Waddell', 'orcid': 'https://orcid.org/0000-0002-3235-9208'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Tom Waddell', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025120810', 'display_name': 'Ian Chau', 'orcid': 'https://orcid.org/0000-0003-0286-8703'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ian Chau', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056345420', 'display_name': 'David Cunningham', 'orcid': 'https://orcid.org/0000-0001-5158-1069'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'David Cunningham', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109673495', 'display_name': 'David González', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Gonzalez', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065638223', 'display_name': 'Alicia Okines', 'orcid': 'https://orcid.org/0000-0002-2068-2593'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alicia Frances Clare Okines', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110174799', 'display_name': 'Andrew Wotherspoon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Andrew Wotherspoon', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075765455', 'display_name': 'Claire Saffery', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Claire Saffery', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037541807', 'display_name': 'Gary Middleton', 'orcid': 'https://orcid.org/0000-0001-5695-3474'}, 'institutions': [{'id': 'https://openalex.org/I2799660017', 'display_name': 'Royal Surrey County Hospital', 'ror': 'https://ror.org/02w7x5c08', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799660017', 'https://openalex.org/I4210146582']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gary Middleton', 'raw_affiliation_strings': ['Royal Surrey County Hospital, Guildford, UK'], 'affiliations': [{'raw_affiliation_string': 'Royal Surrey County Hospital, Guildford, UK', 'institution_ids': ['https://openalex.org/I2799660017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010945467', 'display_name': 'Jonathan Wadsley', 'orcid': 'https://orcid.org/0000-0002-1499-1277'}, 'institutions': [{'id': 'https://openalex.org/I2802720485', 'display_name': 'Weston Park Cancer Centre', 'ror': 'https://ror.org/042gs1a72', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802720485', 'https://openalex.org/I4210102902']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jonathan Wadsley', 'raw_affiliation_strings': ['Weston Park Hospital, Sheffield, UK'], 'affiliations': [{'raw_affiliation_string': 'Weston Park Hospital, Sheffield, UK', 'institution_ids': ['https://openalex.org/I2802720485']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103808805', 'display_name': 'David Ferry', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800117171', 'display_name': 'Russells Hall Hospital', 'ror': 'https://ror.org/04qs81248', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800117171', 'https://openalex.org/I2801954517']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Ferry', 'raw_affiliation_strings': ['Russells Hall Hospital, Dudley, UK'], 'affiliations': [{'raw_affiliation_string': 'Russells Hall Hospital, Dudley, UK', 'institution_ids': ['https://openalex.org/I2800117171']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074217604', 'display_name': 'Wasat Mansoor', 'orcid': 'https://orcid.org/0000-0002-1477-4934'}, 'institutions': [{'id': 'https://openalex.org/I4210133995', 'display_name': 'The Christie NHS Foundation Trust', 'ror': 'https://ror.org/03v9efr22', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133995']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Wasat Mansoor', 'raw_affiliation_strings': ['Christie Hospitals NHS Foundation Trust, Manchester, UK'], 'affiliations': [{'raw_affiliation_string': 'Christie Hospitals NHS Foundation Trust, Manchester, UK', 'institution_ids': ['https://openalex.org/I4210133995']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065507595', 'display_name': 'Tom Crosby', 'orcid': 'https://orcid.org/0000-0003-2232-1756'}, 'institutions': [{'id': 'https://openalex.org/I4210150388', 'display_name': 'Velindre Cancer Centre', 'ror': 'https://ror.org/049sr1d03', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799279586', 'https://openalex.org/I4210150388']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Tom Crosby', 'raw_affiliation_strings': ['Velindre Cancer Centre, Cardiff, UK'], 'affiliations': [{'raw_affiliation_string': 'Velindre Cancer Centre, Cardiff, UK', 'institution_ids': ['https://openalex.org/I4210150388']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002521198', 'display_name': 'Fareeda Y. Coxon', 'orcid': None}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Fareeda Coxon', 'raw_affiliation_strings': ['Northern Centre for Cancer Care, Newcastle-upon-Tyne, UK'], 'affiliations': [{'raw_affiliation_string': 'Northern Centre for Cancer Care, Newcastle-upon-Tyne, UK', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102727019', 'display_name': 'David A. Smith', 'orcid': 'https://orcid.org/0000-0001-7778-7137'}, 'institutions': [{'id': 'https://openalex.org/I283776267', 'display_name': 'Clatterbridge Cancer Centre NHS Foundation Trust', 'ror': 'https://ror.org/05gcq4j10', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I283776267']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Smith', 'raw_affiliation_strings': ['Clatterbridge Centre for Oncology, Wirral, UK'], 'affiliations': [{'raw_affiliation_string': 'Clatterbridge Centre for Oncology, Wirral, UK', 'institution_ids': ['https://openalex.org/I283776267']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017492004', 'display_name': 'Justin S. Waters', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801780664', 'display_name': 'Maidstone Hospital', 'ror': 'https://ror.org/047v2cv91', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I150517883', 'https://openalex.org/I2801780664']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Justin Waters', 'raw_affiliation_strings': ['Kent Oncology Centre, Maidstone, UK'], 'affiliations': [{'raw_affiliation_string': 'Kent Oncology Centre, Maidstone, UK', 'institution_ids': ['https://openalex.org/I2801780664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054875746', 'display_name': 'Timothy Iveson', 'orcid': 'https://orcid.org/0000-0002-4681-2712'}, 'institutions': [{'id': 'https://openalex.org/I2802965805', 'display_name': 'University Hospital Southampton NHS Foundation Trust', 'ror': 'https://ror.org/0485axj58', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802965805']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Timothy Iveson', 'raw_affiliation_strings': ['Southampton University Hospitals NHS Foundation Trust, Southampton, UK'], 'affiliations': [{'raw_affiliation_string': 'Southampton University Hospitals NHS Foundation Trust, Southampton, UK', 'institution_ids': ['https://openalex.org/I2802965805']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010914696', 'display_name': 'Stephen Falk', 'orcid': 'https://orcid.org/0000-0001-6106-3062'}, 'institutions': [{'id': 'https://openalex.org/I2801520950', 'display_name': 'At Bristol', 'ror': 'https://ror.org/039fp5n52', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801520950']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephen Falk', 'raw_affiliation_strings': ['Bristol Haematology and Oncology Centre, Bristol, UK'], 'affiliations': [{'raw_affiliation_string': 'Bristol Haematology and Oncology Centre, Bristol, UK', 'institution_ids': ['https://openalex.org/I2801520950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109953560', 'display_name': 'Sarah Slater', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I225661044', 'display_name': 'Barts Health NHS Trust', 'ror': 'https://ror.org/00b31g692', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I225661044']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sarah Slater', 'raw_affiliation_strings': ['Barts Health NHS Trust, London, UK'], 'affiliations': [{'raw_affiliation_string': 'Barts Health NHS Trust, London, UK', 'institution_ids': ['https://openalex.org/I225661044']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057249944', 'display_name': 'Clare Peckitt', 'orcid': 'https://orcid.org/0000-0001-6343-8462'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Clare Peckitt', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090928234', 'display_name': 'Yolanda Barbáchano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Yolanda Barbachano', 'raw_affiliation_strings': ['The Royal Marsden NHS Foundation Trust, London and Surrey, UK'], 'affiliations': [{'raw_affiliation_string': 'The Royal Marsden NHS Foundation Trust, London and Surrey, UK', 'institution_ids': ['https://openalex.org/I1325846038']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 11, 'corresponding_author_ids': ['https://openalex.org/A5056345420'], 'corresponding_institution_ids': ['https://openalex.org/I1325846038'], 'apc_list': {'value': 6300, 'currency': 'USD', 'value_usd': 6300, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 65.479, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 690, 'citation_normalized_percentile': {'value': 0.999971, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '14', 'issue': '6', 'first_page': '481', 'last_page': '489'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10696', 'display_name': 'Gastric Cancer Management and Outcomes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10696', 'display_name': 'Gastric Cancer Management and Outcomes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13110', 'display_name': 'Colorectal and Anal Carcinomas', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/panitumumab', 'display_name': 'Panitumumab', 'score': 0.8135891}, {'id': 'https://openalex.org/keywords/epirubicin', 'display_name': 'Epirubicin', 'score': 0.77544594}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.6111456}, {'id': 'https://openalex.org/keywords/mucositis', 'display_name': 'Mucositis', 'score': 0.4492067}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.88624716}, {'id': 'https://openalex.org/C2777909004', 'wikidata': 'https://www.wikidata.org/wiki/Q420207', 'display_name': 'Capecitabine', 'level': 4, 'score': 0.87488854}, {'id': 'https://openalex.org/C2778332735', 'wikidata': 'https://www.wikidata.org/wiki/Q417775', 'display_name': 'Panitumumab', 'level': 5, 'score': 0.8135891}, {'id': 'https://openalex.org/C2780835546', 'wikidata': 'https://www.wikidata.org/wiki/Q425122', 'display_name': 'Epirubicin', 'level': 4, 'score': 0.77544594}, {'id': 'https://openalex.org/C2780962732', 'wikidata': 'https://www.wikidata.org/wiki/Q422327', 'display_name': 'Oxaliplatin', 'level': 4, 'score': 0.7605548}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7275864}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.6111456}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.5296117}, {'id': 'https://openalex.org/C2778850193', 'wikidata': 'https://www.wikidata.org/wiki/Q3775974', 'display_name': 'Febrile neutropenia', 'level': 4, 'score': 0.46822283}, {'id': 'https://openalex.org/C2778496288', 'wikidata': 'https://www.wikidata.org/wiki/Q6931269', 'display_name': 'Mucositis', 'level': 3, 'score': 0.4492067}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.41528067}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.40472454}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3604504}, {'id': 'https://openalex.org/C2777063308', 'wikidata': 'https://www.wikidata.org/wiki/Q1435822', 'display_name': 'Neutropenia', 'level': 3, 'score': 0.33885998}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.33461344}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.30202788}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.26483363}, {'id': 'https://openalex.org/C2781187634', 'wikidata': 'https://www.wikidata.org/wiki/Q20969980', 'display_name': 'KRAS', 'level': 4, 'score': 0.14914408}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.10137212}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069287', 'descriptor_name': 'Capecitabine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016009', 'descriptor_name': 'Chi-Square Distribution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057239', 'descriptor_name': 'Early Termination of Clinical Trials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015251', 'descriptor_name': 'Epirubicin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D015251', 'descriptor_name': 'Epirubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057194', 'descriptor_name': 'Intention to Treat Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016015', 'descriptor_name': 'Logistic Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015999', 'descriptor_name': 'Multivariate Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016017', 'descriptor_name': 'Odds Ratio', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009944', 'descriptor_name': 'Organoplatinum Compounds', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D009944', 'descriptor_name': 'Organoplatinum Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077150', 'descriptor_name': 'Oxaliplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077544', 'descriptor_name': 'Panitumumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016016', 'descriptor_name': 'Proportional Hazards Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006113', 'descriptor_name': 'United Kingdom', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s1470-2045(13)70096-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116900674', 'display_name': 'The Lancet Oncology', 'issn_l': '1470-2045', 'issn': ['1470-2045', '1474-5488'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3669518', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669518', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23594787', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3669518', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.56, 'display_name': 'No poverty', 'id': 'https://metadata.un.org/sdg/1'}, {'score': 0.41, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1576726818', 'https://openalex.org/W1965848984', 'https://openalex.org/W1976651872', 'https://openalex.org/W1981989535', 'https://openalex.org/W1983883123', 'https://openalex.org/W2040083298', 'https://openalex.org/W2058539457', 'https://openalex.org/W2074478596', 'https://openalex.org/W2084978911', 'https://openalex.org/W2091571283', 'https://openalex.org/W2095605190', 'https://openalex.org/W2098354753', 'https://openalex.org/W2098378509', 'https://openalex.org/W2099928163', 'https://openalex.org/W2104580737', 'https://openalex.org/W2126078998', 'https://openalex.org/W2128328462', 'https://openalex.org/W2129255527', 'https://openalex.org/W2129310383', 'https://openalex.org/W2139248078', 'https://openalex.org/W2139777177', 'https://openalex.org/W2144425748', 'https://openalex.org/W2145070131', 'https://openalex.org/W2147340476', 'https://openalex.org/W2149051154', 'https://openalex.org/W2152362765', 'https://openalex.org/W2277724081', 'https://openalex.org/W2584009879', 'https://openalex.org/W2964651003', 'https://openalex.org/W2998875153', 'https://openalex.org/W367129424'], 'related_works': ['https://openalex.org/W4389485761', 'https://openalex.org/W4236171035', 'https://openalex.org/W3144346200', 'https://openalex.org/W2767371907', 'https://openalex.org/W2409395100', 'https://openalex.org/W2407798196', 'https://openalex.org/W2088713834', 'https://openalex.org/W2055562862', 'https://openalex.org/W1987254926', 'https://openalex.org/W1563397023'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165411051', 'counts_by_year': [{'year': 2024, 'cited_by_count': 20}, {'year': 2023, 'cited_by_count': 33}, {'year': 2022, 'cited_by_count': 36}, {'year': 2021, 'cited_by_count': 58}, {'year': 2020, 'cited_by_count': 54}, {'year': 2019, 'cited_by_count': 57}, {'year': 2018, 'cited_by_count': 72}, {'year': 2017, 'cited_by_count': 90}, {'year': 2016, 'cited_by_count': 76}, {'year': 2015, 'cited_by_count': 97}, {'year': 2014, 'cited_by_count': 74}, {'year': 2013, 'cited_by_count': 22}], 'updated_date': '2025-01-08T23:36:32.559382', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
