Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2165367810', 'doi': 'https://doi.org/10.4049/jimmunol.165.12.7330', 'title': 'A Mechanism for IL-10-Mediated Diabetes in the Nonobese Diabetic (NOD) Mouse: ICAM-1 Deficiency Blocks Accelerated Diabetes', 'display_name': 'A Mechanism for IL-10-Mediated Diabetes in the Nonobese Diabetic (NOD) Mouse: ICAM-1 Deficiency Blocks Accelerated Diabetes', 'publication_year': 2000, 'publication_date': '2000-12-15', 'ids': {'openalex': 'https://openalex.org/W2165367810', 'doi': 'https://doi.org/10.4049/jimmunol.165.12.7330', 'mag': '2165367810', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11120869'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.165.12.7330', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/165/12/7330/1127316/7330.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/165/12/7330/1127316/7330.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078553844', 'display_name': 'Balaji Balasa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Balaji Balasa', 'raw_affiliation_strings': ['Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105843134', 'display_name': 'Antonio La Cava', 'orcid': 'https://orcid.org/0000-0002-8839-0933'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Antonio La Cava', 'raw_affiliation_strings': ['Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028331671', 'display_name': 'Kurt Van Gunst', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kurt Van Gunst', 'raw_affiliation_strings': ['Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057065981', 'display_name': 'Lorraine Mocnik', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lorraine Mocnik', 'raw_affiliation_strings': ['Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008763069', 'display_name': 'Deepika Balakrishna', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Deepika Balakrishna', 'raw_affiliation_strings': ['Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069985449', 'display_name': 'Nancy Nguyen', 'orcid': 'https://orcid.org/0000-0003-2131-2444'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nancy Nguyen', 'raw_affiliation_strings': ['Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002011082', 'display_name': 'Lee Tucker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lee Tucker', 'raw_affiliation_strings': ['Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074801227', 'display_name': 'Nora Sarvetnick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nora Sarvetnick', 'raw_affiliation_strings': ['Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.343, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 64, 'citation_normalized_percentile': {'value': 0.885493, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '165', 'issue': '12', 'first_page': '7330', 'last_page': '7337'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11171', 'display_name': 'Genetics and Pathogenesis of Type 1 Diabetes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11171', 'display_name': 'Genetics and Pathogenesis of Type 1 Diabetes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Natural Killer Cells in Immunity', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/insulitis', 'display_name': 'Insulitis', 'score': 0.9728956}, {'id': 'https://openalex.org/keywords/nod-mice', 'display_name': 'NOD mice', 'score': 0.9218193}, {'id': 'https://openalex.org/keywords/adoptive-cell-transfer', 'display_name': 'Adoptive cell transfer', 'score': 0.64579207}, {'id': 'https://openalex.org/keywords/islet-autoimmunity', 'display_name': 'Islet Autoimmunity', 'score': 0.532721}, {'id': 'https://openalex.org/keywords/diabetes-mellitus', 'display_name': 'Diabetes Mellitus', 'score': 0.5158}, {'id': 'https://openalex.org/keywords/type-1-diabetes', 'display_name': 'Type 1 Diabetes', 'score': 0.510294}, {'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.5018532}], 'concepts': [{'id': 'https://openalex.org/C2779511750', 'wikidata': 'https://www.wikidata.org/wiki/Q922215', 'display_name': 'Insulitis', 'level': 4, 'score': 0.9728956}, {'id': 'https://openalex.org/C2778013207', 'wikidata': 'https://www.wikidata.org/wiki/Q1961243', 'display_name': 'NOD mice', 'level': 4, 'score': 0.9218193}, {'id': 'https://openalex.org/C55851684', 'wikidata': 'https://www.wikidata.org/wiki/Q518390', 'display_name': 'Nod', 'level': 3, 'score': 0.8625189}, {'id': 'https://openalex.org/C90375314', 'wikidata': 'https://www.wikidata.org/wiki/Q3537484', 'display_name': 'Adoptive cell transfer', 'level': 4, 'score': 0.64579207}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.5724537}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.53780216}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5265456}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.5018532}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.43525067}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.40990943}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33740842}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.2929648}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.1799767}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.1233511}], 'mesh': [{'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018799', 'descriptor_name': 'Intercellular Adhesion Molecule-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019264', 'descriptor_name': 'Adoptive Transfer', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001324', 'descriptor_name': 'Autoantigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D001324', 'descriptor_name': 'Autoantigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005968', 'descriptor_name': 'Glutamate Decarboxylase', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005968', 'descriptor_name': 'Glutamate Decarboxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018799', 'descriptor_name': 'Intercellular Adhesion Molecule-1', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D018799', 'descriptor_name': 'Intercellular Adhesion Molecule-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007515', 'descriptor_name': 'Islets of Langerhans', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007515', 'descriptor_name': 'Islets of Langerhans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017710', 'descriptor_name': 'Lymphocyte Transfusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016688', 'descriptor_name': 'Mice, Inbred NOD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': 'Q000637', 'qualifier_name': 'transplantation', 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019076', 'descriptor_name': 'Transgenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019076', 'descriptor_name': 'Transgenes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.165.12.7330', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/165/12/7330/1127316/7330.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11120869', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.165.12.7330', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/165/12/7330/1127316/7330.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.88, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W146153562', 'https://openalex.org/W1481803988', 'https://openalex.org/W1487295185', 'https://openalex.org/W1513672361', 'https://openalex.org/W1517658874', 'https://openalex.org/W1597836403', 'https://openalex.org/W1598195946', 'https://openalex.org/W1794035985', 'https://openalex.org/W1986639127', 'https://openalex.org/W1992069433', 'https://openalex.org/W2036500213', 'https://openalex.org/W2041469322', 'https://openalex.org/W2045339797', 'https://openalex.org/W2062572904', 'https://openalex.org/W2065683540', 'https://openalex.org/W2071756824', 'https://openalex.org/W2081459814', 'https://openalex.org/W2092512708', 'https://openalex.org/W2096234619', 'https://openalex.org/W2111365374', 'https://openalex.org/W2118444574', 'https://openalex.org/W2133487448', 'https://openalex.org/W2142748670', 'https://openalex.org/W2150195134', 'https://openalex.org/W2168941432', 'https://openalex.org/W2169056709', 'https://openalex.org/W2169279497', 'https://openalex.org/W4313333836', 'https://openalex.org/W82670290'], 'related_works': ['https://openalex.org/W2472150133', 'https://openalex.org/W2434178130', 'https://openalex.org/W2126232873', 'https://openalex.org/W2109245226', 'https://openalex.org/W2100599721', 'https://openalex.org/W2098176258', 'https://openalex.org/W2065683540', 'https://openalex.org/W2056965678', 'https://openalex.org/W1974599629', 'https://openalex.org/W1969488621'], 'abstract_inverted_index': {'Neonatal': [0], 'islet-specific': [1, 189], 'expression': [2], 'of': [3, 13, 18, 30, 66, 79, 103, 109, 115, 134, 162, 178, 188, 203, 209], 'IL-10': [4, 23, 52, 93, 97, 122, 231], 'in': [5, 32, 53, 175, 199, 219], 'nonobese': [6], 'diabetic': [7, 47], '(NOD)': [8], 'mice': [9, 21, 34, 86, 139, 145], 'accelerates': [10, 240], 'the': [11, 54, 64, 69, 101, 112, 160, 176, 179, 184, 200], 'onset': [12], 'diabetes,': [14], 'whereas': [15], 'systemic': [16], 'treatment': [17], 'young': [19], 'NOD': [20, 48, 81, 144, 223], 'with': [22], 'prevents': [24], 'diabetes.': [25, 59, 104, 150], 'The': [26, 118, 167], 'mechanism': [27], 'for': [28, 100], 'acceleration': [29, 102], 'diabetes': [31, 125, 156, 205, 241], 'IL-10-NOD': [33, 116, 138, 221], 'is': [35, 98, 232], 'not': [36, 68, 95], 'known.': [37], 'Here': [38], 'we': [39], 'show,': [40], 'by': [41, 159], 'adoptive': [42, 207], 'transfers,': [43], 'that': [44, 63, 91, 121, 132, 170, 229], 'prediabetic': [45], 'or': [46], 'splenocytes': [49, 82], 'upon': [50], 'encountering': [51], 'pancreatic': [55, 92, 230], 'islets': [56], 'readily': [57], 'promoted': [58], 'This': [60], 'outcome': [61], 'suggests': [62, 120], 'compartment': [65], 'exposure,': [67], 'timing,': [70], 'confers': [71], 'proinflammatory': [72], 'effects': [73], 'on': [74, 111], 'this': [75], 'molecule.': [76], 'Moreover,': [77], 'injection': [78], 'IL-10-deficient': [80], 'into': [83, 137, 143], 'transgenic': [84], 'IL-10-NOD.scid/scid': [85], 'elicited': [87], 'accelerated': [88, 147], 'disease,': [89], 'demonstrating': [90], 'but': [94], 'endogenous': [96], 'sufficient': [99, 233], 'Immunohistochemical': [105], 'analysis': [106], 'revealed': [107], 'hyperexpression': [108], 'ICAM-1': [110, 135, 171, 194], 'vascular': [113], 'endothelium': [114], 'mice.': [117, 224], 'finding': [119], 'may': [123], 'promote': [124], 'via': [126, 242], 'an': [127, 243], 'ICAM-1-dependent': [128, 244], 'pathway.': [129, 245], 'We': [130], 'found': [131], 'introduction': [133], 'deficiency': [136], 'as': [140, 142], 'well': [141], 'prevented': [146], 'insulitis': [148, 154], 'and': [149, 155, 222, 239], 'Failure': [151], 'to': [152, 215, 234], 'develop': [153], 'was': [157], 'preceded': [158], 'absence': [161], 'GAD65-specific': [163], 'T': [164, 190, 212], 'cell': [165], 'responses.': [166], 'data': [168], 'suggest': [169], 'plays': [172], 'a': [173, 197], 'role': [174, 198], 'formation': [177], '"immunological': [180], 'synapse",': [181], 'thereby': [182], 'affecting': [183], 'generation': [185], 'and/or': [186], 'expansion': [187], 'cells.': [191], 'In': [192], 'addition,': [193], 'also': [195], 'played': [196], 'effector': [201], 'phase': [202], 'autoimmune': [204, 237], 'because': [206], 'transfer': [208], 'diabetogenic': [210], 'BDC2.5': [211], 'cells': [213], 'failed': [214], 'elicit': [216], 'clinical': [217], 'disease': [218], 'ICAM-1-deficient': [220], 'These': [225], 'findings': [226], 'provide': [227], 'evidence': [228], 'drive': [235], 'pathogenic': [236], 'responses': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165367810', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-09T11:39:18.137735', 'created_date': '2016-06-24'}