Tumor Antigens and Proteomics from the Point of View of the Major Histocompatibility Complex Peptides

Name: Work Video:
Duration: 3 min 30 s
Arie Admon; Eilon Barnea; Tamar Ziv
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1159, 1171, 1176, 1188, 1197, 1207, 1221, 1239, 1261, 1272, 1288, 1298, 1322, 1471, 1516, 1623, 1650, 1665, 1668, 1685, 1720, 1777, 1842, 1888, 1904, 2015, 2070, 2119, 2138, 2183, 2187, 2192, 2217, 2233, 2243, 2249, 2313, 2336, 2366, 2379, 2387, 2411, 2446, 2471, 2521, 2595, 2633, 2643, 2648, 2659, 2710, 2731, 2749, 2862, 2953, 3006, 3030, 3033, 3040, 3052, 3152, 3191, 3278, 3361, 3370, 3377, 3400, 3447, 3468, 3491, 3502, 3516, 3545, 3663, 3671, 3721, 3749, 3752, 3770, 3780, 3786, 3798, 3812, 3832, 3954, 4119, 4179, 4187, 4191, 4227, 4239, 4263, 4286, 4325, 4348, 4360, 4367, 4413, 4433], 'cancer': [8, 22, 36, 195, 236, 263, 277, 291, 450, 491, 1109, 1305, 1356, 1545, 1567, 1651, 1673, 1704, 1729, 1762, 1828, 1846, 2121, 2368, 2441, 2599, 2617, 2620, 2868, 3080, 3114, 3254, 3257, 3316, 3331, 3682, 3700, 3739], 'cells': [9, 37, 95, 264, 292, 350, 640, 822, 864, 876, 878, 897, 1035, 1090, 1098, 1107, 1329, 1357, 1390, 1674, 1705, 2092, 2442, 2565, 2801, 2808, 2830, 2925, 2934, 3029, 3045, 3081, 3290, 3364, 3455, 3551, 3615, 3624, 3637, 3680, 3788, 3790, 3811, 3968], 'serves': [10, 265, 1165], 'both': [11, 266, 775, 3638], 'as': [12, 25, 267, 280, 610, 1014, 1154, 1168, 1185, 1217, 1345, 1421, 1662, 1741, 1756, 2021, 2769, 3108, 3110, 3498, 3500, 3504, 3509, 3835, 4245, 4312], 'a': [13, 26, 268, 281, 516, 562, 569, 886, 954, 1186, 1266, 1621, 1663, 1686, 1710, 1893, 1901, 2188, 2478, 2641, 2652, 2671, 3157, 3553, 3719, 3959, 4014], 'source': [14, 269], 'for': [15, 19, 119, 179, 185, 205, 235, 270, 274, 374, 434, 440, 460, 490, 540, 556, 578, 597, 805, 824, 1219, 1237, 1242, 1341, 1374, 1401, 1423, 1520, 1637, 1725, 1771, 1914, 1968, 2024, 2049, 2086, 2231, 2257, 2384, 2437, 2518, 2587, 2737, 2739, 2992, 3019, 3056, 3159, 3195, 3349, 3568, 3600, 3625, 3738, 3755, 3918, 3958, 4013, 4390], 'new': [16, 147, 181, 208, 271, 402, 436, 463, 573, 1181, 1240, 1338, 2635, 3566, 4010, 4053, 4117], 'tumor': [17, 182, 272, 437, 1309, 1328, 1339, 1370, 1473, 1496, 1714, 1860, 1874, 1895, 2089, 2315, 2338, 2389, 2413, 2624, 2636, 2714, 2775, 2838, 2872, 2928, 2955, 3028, 3053, 3161, 3261, 3350, 3363, 3632, 3756, 3787, 3886, 4241], 'antigens': [18, 273, 687, 1373, 1378, 1474, 1695, 1764, 1767, 1875, 2140, 2218, 2423, 2637, 2760, 2929, 3008, 3054, 3372, 3838, 3843, 4145, 4242], 'development': [20, 275, 1515, 3190], 'immunotherapy': [23, 278, 1375, 1590, 1638, 1915, 1967, 2018, 2048, 3047, 3228, 3332, 3434, 3757, 4203], 'and': [24, 60, 131, 141, 164, 184, 197, 229, 279, 315, 386, 396, 419, 439, 452, 484, 575, 623, 732, 777, 871, 898, 911, 931, 964, 1045, 1066, 1146, 1157, 1209, 1229, 1245, 1253, 1301, 1331, 1383, 1454, 1498, 1743, 1745, 1759, 1765, 1775, 1862, 1971, 2019, 2080, 2090, 2101, 2224, 2342, 2398, 2405, 2430, 2582, 2602, 2772, 2811, 2950, 2983, 2996, 3035, 3248, 3276, 3291, 3298, 3304, 3406, 3477, 3520, 3548, 3561, 3605, 3641, 3644, 3767, 3825, 3827, 3840, 3845, 4114, 4340, 4393], 'rich': [27, 282], 'information': [28, 283], 'resource': [29, 284], 'about': [30, 285, 3337], 'the': [31, 35, 65, 76, 82, 89, 94, 97, 142, 151, 226, 243, 286, 290, 320, 331, 337, 344, 349, 352, 397, 406, 481, 498, 532, 538, 541, 544, 551, 592, 598, 611, 616, 619, 627, 629, 716, 719, 729, 739, 744, 748, 764, 795, 834, 837, 840, 849, 852, 892, 895, 903, 912, 957, 1009, 1077, 1126, 1137, 1140, 1148, 1169, 1191, 1194, 1198, 1205, 1212, 1222, 1256, 1270, 1273, 1286, 1320, 1323, 1333, 1360, 1392, 1514, 1647, 1666, 1790, 1843, 1889, 1905, 1911, 1918, 2071, 2117, 2241, 2250, 2364, 2380, 2385, 2409, 2519, 2572, 2649, 2660, 2682, 2708, 2717, 2747, 2786, 2948, 3031, 3037, 3041, 3050, 3069, 3079, 3189, 3347, 3359, 3368, 3371, 3375, 3378, 3452, 3620, 3631, 3649, 3669, 3672, 3771, 3774, 3792, 3815, 3830, 3836, 3841, 3955, 4120, 4180, 4185, 4192, 4216, 4235, 4246, 4308, 4313, 4322, 4326, 4329, 4333, 4358, 4374], 'protein': [32, 78, 287, 333, 547, 960, 1130, 2779, 3154], 'content': [33, 288], '(their': [38, 293], 'proteome).': [39, 99, 294, 354], 'Thousands': [40, 295], 'different': [42, 58, 161, 166, 297, 313, 416, 421, 524, 528, 2077, 3007, 3038, 3761], 'MHC': [43, 83, 100, 111, 124, 157, 167, 173, 232, 253, 298, 338, 355, 366, 379, 412, 422, 428, 487, 508, 722, 749, 757, 789, 825, 880, 934, 1144, 1152, 1202, 1213, 1262, 1299, 2473, 2689, 3101, 3269, 3379, 3493, 3517, 3558, 3603, 3750, 3794, 3817, 4232, 4264, 4290, 4361, 4391, 4408], 'peptides': [44, 101, 128, 158, 174, 233, 299, 356, 383, 413, 429, 488, 714, 769, 829, 884, 910, 1145, 1203, 1214, 1263, 1300, 1384, 1420, 2569, 2686, 2835, 3270, 3494, 3523, 3751, 4233, 4265, 4309, 4327, 4362, 4404], 'are': [45, 55, 129, 144, 215, 300, 310, 384, 399, 470, 710, 726, 751, 761, 783, 791, 803, 830, 1047, 1251, 1376, 1381, 1599, 1639, 1656, 1660, 1697, 1700, 1707, 1722, 1733, 1749, 1834, 1925, 2227, 2238, 2655, 2762, 2805, 2836, 2968, 2977, 3009, 3065, 3072, 3237, 3271], 'normally': [46, 301, 831, 1735, 1750], 'displayed': [47, 159, 302, 414, 2687], 'by': [48, 106, 133, 160, 165, 218, 303, 361, 388, 415, 420, 473, 637, 688, 807, 836, 993, 1049, 1086, 1136, 1147, 1278, 1295, 1358, 1476, 2076, 2219, 2290, 2427, 2477, 2640, 2688, 2870, 2978, 3048, 3078, 3286, 3299, 3552, 3802, 3823, 3872, 3880, 3922, 3965, 4018, 4062, 4089, 4093, 4147, 4259, 4284, 4342], 'each': [49, 304, 2954], 'cell,': [50, 305], 'where': [51, 306, 1211], 'most': [52, 63, 307, 318, 737, 780, 1634, 2756, 2791, 3621], 'them': [54, 309, 1778, 2586, 3279, 3629], 'derived': [56, 311, 770, 2570], 'from': [57, 109, 312, 364, 523, 715, 771, 1387, 2052, 2571, 3472, 3784, 4267, 4289, 4363], 'proteins': [59, 92, 188, 209, 314, 347, 443, 464, 1250, 1382, 1698, 1734, 2193, 2234, 2976, 3063, 4368], 'thus': [61, 316, 645, 1164, 1264], 'represent': [62, 317], 'cellular': [66, 77, 321, 332, 593, 643, 1127, 1223, 1274, 1669, 3601], 'proteome.': [67, 322], 'However,': [68, 323, 2742, 3000], 'in': [69, 93, 324, 348, 513, 543, 591, 736, 743, 763, 833, 846, 891, 1055, 1076, 1100, 1108, 1255, 1391, 1395, 1439, 1450, 1513, 1672, 1713, 1737, 1752, 1816, 1878, 1883, 1886, 1899, 2037, 2194, 2204, 2240, 2286, 2352, 2440, 2598, 2651, 2713, 2755, 2765, 2790, 2809, 2812, 2867, 2884, 2936, 2962, 2971, 2981, 3027, 3036, 3106, 3113, 3179, 3188, 3300, 3305, 3409, 3430, 3451, 3642, 3681, 3764, 3809, 3829, 4134, 4332], 'contrast': [70, 325], 'to': [71, 88, 194, 326, 343, 449, 571, 586, 615, 633, 718, 794, 858, 877, 1039, 1057, 1083, 1125, 1190, 1226, 1247, 1315, 1318, 1326, 1336, 1354, 1645, 1703, 1709, 1716, 1782, 1789, 1810, 1838, 1927, 2054, 2116, 2363, 2619, 2706, 2892, 2959, 2989, 3024, 3067, 3075, 3256, 3283, 3335, 3341, 3355, 3525, 3618, 3648, 3660, 3805, 4231, 4320, 4328, 4356, 4370, 4407], 'standard': [72, 219, 327, 474], 'proteomics,': [73, 328], 'which': [74, 329, 782, 802, 1249, 1380, 1659, 1721, 1732, 1748, 2236, 2667, 3656, 4222], 'surveys': [75, 330], 'contents,': [79, 334], 'analyses': [80, 251, 335, 506, 1260, 1297], 'correspond': [86, 341, 4230], 'more': [87, 342, 1929, 2228, 3666], 'rapidly': [90, 345], 'degrading': [91, 346], '(i.e.': [96, 351], 'transient': [98, 353], 'can': [102, 175, 201, 357, 430, 456, 1215, 1234, 1292, 1351], 'be': [103, 177, 203, 358, 432, 458, 859, 1235, 1293, 1352, 1928, 2960, 2990, 3025, 3076, 3284, 3356, 3526, 3619, 4321, 4371], 'efficiently': [104, 359], 'purified': [105, 127, 360, 382, 4349], 'affinity': [107, 362], 'chromatography': [108, 363, 2097], 'membranal': [110, 365], 'molecules,': [112, 367], 'or': [113, 368, 605, 1016, 1344, 2450, 2728, 2777, 2780, 3373, 3449, 3507, 3511, 4249], 'preferably': [114, 369, 1642], 'following': [115, 370], 'transfection': [116, 371], 'vectors': [118, 373], 'expression': [120, 375, 690, 2221, 2448, 2597, 2712, 3051, 3369, 3781], 'recombinant': [122, 377, 689, 2220], 'soluble': [123, 378, 665], 'molecules.': [125, 380, 1347, 2692, 4291], 'resolved': [130, 385], 'analyzed': [132, 387], 'capillary': [134, 389], 'high-pressure': [135, 390], 'liquid': [136, 391, 696, 2096], 'chromatography-electrospray': [137, 392], 'ionization-tandem': [138, 393], 'mass': [139, 394, 699, 703, 4344], 'spectrometry,': [140, 395], 'data': [143, 398, 2453, 2730], 'deciphered': [145, 400], 'with': [146, 242, 401, 497, 550, 641, 768, 798, 882, 1033, 1369, 1591, 1620, 1786, 1813, 1818, 1872, 1934, 2246, 2759, 2803, 2832, 2923, 2931, 2998, 3003, 3229, 3295, 3358, 3514, 3556, 3630, 3718, 3814, 4123, 4184, 4204], 'software': [148, 403, 4352], 'tools': [149, 404, 4353], 'enabling': [150, 405], 'creation': [152, 407], 'large': [154, 409, 1932, 3004], 'databanks': [155, 410], 'cell': [162, 417, 675, 720, 741, 796, 814, 854, 2382, 3736], 'types': [163, 418, 742], 'haplotypes.': [168, 423], 'These': [169, 199, 424, 454, 608, 4316], 'lists': [170, 200, 425, 455], 'identified': [172, 427, 2075, 2252, 2426, 2957, 2986], 'now': [176, 431], 'used': [178, 204, 433, 459, 658, 2085, 2736, 3055, 4355], 'searching': [180, 435, 2436], 'antigens,': [183, 438, 755, 1731, 1747, 3633], 'identification': [186, 206, 228, 441, 461, 483, 685, 2118, 2216, 2232, 2312, 2365, 2386, 2670, 3831, 4186, 4226], 'whose': [189, 444], 'rapid': [190, 445], 'degradation': [191, 446, 963, 1141, 1163], 'is': [192, 239, 447, 494, 537, 559, 636, 856, 1031, 1122, 1133, 1916, 2638, 2702, 2744, 3059, 3156, 3773, 3876, 4091, 4215, 4223], 'significant': [193, 234, 448, 489], 'progression': [196, 451, 3351], 'metastasis.': [198, 453], 'also': [202, 240, 457, 495, 568, 1134, 1184, 1246, 2425, 2764, 3457], 'yet': [211, 466], 'unknown': [212, 467], 'function': [213, 468], 'that': [214, 469, 889, 1291, 1699, 1910, 2563, 2719, 2746, 2761, 3062, 3064, 3365, 4229, 4405], 'not': [216, 471, 560, 1166, 1701, 1848, 2753, 2784, 2883], 'detected': [217, 472, 2289], 'proteomics': [220, 247, 475, 502, 536, 1208, 1280, 1290, 2226], 'approaches.': [221, 476, 1281], 'This': [222, 477, 1232, 1282, 3819], 'review': [223, 478, 1283], 'focuses': [224, 479, 534, 1284], 'on': [225, 480, 1095, 1285, 1304, 1308, 1312, 1332, 2408, 2435, 3778, 3878, 3927, 4023, 4059, 4225], 'presentation,': [227, 482], 'analysis': [230, 485, 2182, 2335, 2404, 2445], 'immunotherapy.': [237, 492, 1110, 1306, 1455, 1499, 1726, 1863, 3626, 3683, 3740], 'It': [238, 493, 1132, 1200, 1907], 'concerned': [241, 496], 'aspects': [244, 499, 1220], 'human': [246, 501, 670, 753, 1289, 1451, 1472, 1974, 2287, 2314, 2337, 2388, 2733, 2963, 2975, 3001, 3306, 3431, 3469, 3873, 3961, 4060, 4189], 'observed': [248, 503, 1294, 1898, 3458, 4300], 'through': [249, 504, 811, 1091, 1366], 'large-scale': [250, 505, 1259, 1296, 3015], 'peptides.': [254, 509, 869, 4350], 'proteome': [511, 1275], 'resembles': [512], 'many': [514, 533, 1879], 'ways': [515, 628, 1317], 'Japanese': [517], 'rock': [518], 'garden;': [519], 'looking': [520, 596], 'at': [521, 866, 1042, 1174, 1204, 1495, 1859, 1917, 4301, 4304], 'it': [522, 2743, 3058], 'viewpoints': [525], 'reveals': [526], 'its': [527, 642, 2406, 2993], 'intricacies.': [529], 'One': [530, 625, 3769], 'search': [539], 'changes': [542, 558, 590], 'patterns': [545], 'expressions': [548], 'associated': [549, 3357], 'onset': [552, 620], 'diseases.': [554, 624, 1231], 'Searching': [555], 'such': [557, 953, 2768, 3834], 'merely': [561], 'matter': [563], 'scientific': [565], 'curiosity': [566], 'but': [567, 1183, 1706, 2882], 'means': [570, 1187], 'develop': [572], 'drugs': [574], 'treatments': [576], 'modalities': [577], 'these': [579, 588, 1046, 1243, 3488], 'ailments.': [580], 'immune': [582, 617, 630, 1010, 1120, 1160, 1192, 1324, 1349, 1364, 1832, 1936, 3654, 3807], 'system,': [583], 'likewise,': [584], 'attempts': [585, 632], 'identify': [587, 1337], 'minute': [589], 'proteome,': [594], 'while': [595, 1892], 'presence': [599, 1078], 'telltale': [601], 'amounts': [602], 'abnormal': [604], 'foreign': [606, 1015], 'proteins.': [607], 'serve': [609, 1216], 'alarm': [612], 'signals,': [613], 'indicating': [614], 'system': [618, 631, 1011, 1193, 1325, 1350], 'infections': [622], 'eliminate': [634], 'pathogens': [635], 'killing': [638, 893], 'infected': [639, 896], 'arm,': [644], 'preventing': [646], 'further': [647, 900, 2258, 2584, 3293], 'spread': [648, 901], 'disease.': [650, 2939], '1The': [656], 'abbreviations': [657], 'are:': [659], 'MHC,': [660], 'complex;': [663, 668], 'sMHC,': [664], 'HLA,': [669], 'leukocytes': [671, 754], 'antigen;': [672], 'TCR,': [673], 'T': [674, 809, 813, 821, 853, 863, 875, 994, 1034, 1089, 1477, 2480, 2865, 3289, 3454, 3550, 3636, 3810, 3882, 3925, 3967, 4021, 4064, 4095, 4148], 'receptor;': [676], 'TSA,': [677], 'tumor-specific': [678, 1377, 2863, 4124], 'antigens;': [679, 682], 'TAA,': [680], 'tumor-associated': [681, 2139, 2472], 'SEREX,': [683], 'serological': [684, 2225, 2412], 'cloning;': [691], 'ER,': [692], 'endoplasmic': [693, 765], 'reticulum;': [694], 'LC,': [695], 'chromatography;': [697], 'MS,': [698], 'spectrometry;': [700, 704], 'MS/MS,': [701], 'tandem': [702, 4343], 'ORF,': [705], 'open': [706], 'reading': [707], 'frame.': [708], 'molecules': [709, 725, 750, 760, 790, 826, 881, 1153, 4409], 'shuttles,': [712], 'transporting': [713], 'cytoplasm': [717], 'surface.': [721], 'class': [723, 758, 935, 2474, 2690, 3102, 3426, 3518, 3521, 3559, 3562], 'I': [724, 759, 936, 2475, 2691, 3427, 3519, 3560], 'products': [727, 1142], 'MHC-A,': [730], '-B,': [731], '-C': [733], 'genes': [734, 2438], 'expressed': [735, 1252, 1661, 1708, 1736, 1751, 2190, 2285, 2763, 3026], 'nucleated': [740], 'body': [745, 1030, 1393], '(in': [746], 'humans': [747], 'called': [752], 'HLA).': [756], 'loaded': [762], 'reticulum': [766], '(ER)': [767], 'proteasomal': [772], 'proteolysis': [773], 'normal': [776, 1389, 1717, 2091, 2766, 2932], 'pathogenic': [778], 'proteins,': [779, 1172, 1182, 1641, 1658, 2666, 3506], '8–10': [784], 'amino': [785, 1178, 4236, 4298, 4364], 'acids': [786, 1179, 4237, 4299], 'long.': [787], 'then': [792, 2583, 3292], 'shuttled': [793], 'surface': [797, 2102], 'their': [799, 812, 1177, 1302, 1772, 1935, 2588, 2669, 2720, 3803], 'cargo,': [801], 'presented': [804, 4088], 'scrutiny': [806], 'CD8+': [808, 1807, 3549], 'lymphocytes': [810, 2866, 3883, 3926, 4022], 'receptor': [815], '(TCR).': [816], 'To': [817, 3486], 'prevent': [818, 1058], 'autoimmunity,': [819], 'high-affinity': [820, 867], 'specific': [823, 1873, 1966, 2017, 3453, 4269], 'presenting': [827, 879], '"self"': [828], 'eliminated': [832], 'thymus': [835, 1065], 'end': [838], 'embryonic': [841, 1657], 'stage': [842, 1969, 1972, 2025], '(central': [843], 'tolerance).': [844], 'Therefore,': [845], 'healthy': [847], 'individuals': [848, 3813], 'majority': [850, 2069, 3032], 'population': [855], 'thought': [857], 'composed': [860], 'those': [862, 1643], 'recognizing': [865], '"non-self"': [868], 'Tight': [870], 'long-lasting': [872, 3338], 'binding': [873, 1038, 3604, 4219, 4254, 4330], 'non-self': [883, 2980], 'elicits': [885], 'cytotoxic': [887, 2864, 3096, 3288], 'response': [888, 1365, 1785, 1833, 1885, 3808], 'results': [890, 2935], 'prevents': [899], 'disease': [904, 1921, 2891], '(1Kourilsky': [905], 'P.': [906, 1580, 2679, 3094, 3218, 3392, 3852, 3858, 3911, 4034, 4044, 4050, 4074, 4084, 4164], 'Fazilleau': [907], 'N.': [908, 1462, 1563, 2675, 3388, 3696], 'Self': [909], 'peptidic': [913], 'self.': [914], 'Int.': [915, 3412, 4126], 'Rev.': [916, 1019, 1070, 1112, 3685, 3742], 'Immunol.': [917, 941, 997, 1020, 1069, 1113, 1404, 1425, 1480, 1501, 1550, 1865, 2058, 2319, 2485, 2627, 2695, 2842, 3264, 3321, 3481, 3686, 4099, 4150], '2001;': [918, 942, 970, 1114, 1457, 1482, 1502, 1690, 1866, 2125, 2372, 2418, 2578, 2608, 2628, 3118, 3265, 3687, 4196], '20:': [919], '575-591Crossref': [920], 'PubMed': [921, 945, 1001, 1024, 1533, 1554, 2063, 2150, 2323, 2905, 3173, 3208, 3325, 4158], 'Scopus': [922, 946, 1002, 1025, 1534, 1555, 2064, 2151, 2324, 2906, 3174, 3209, 3326, 4159], '(2)': [923], 'Google': [924, 948, 1004, 1027, 1117, 1536, 1557, 2066, 2153, 2326, 2908, 3176, 3211, 3328, 3690, 4161], 'Scholar,': [925, 949, 973, 1005, 1408, 1430, 1446, 1460, 1485, 1505, 1537, 1558, 1574, 1609, 1984, 2035, 2128, 2154, 2202, 2304, 2327, 2350, 2375, 2397, 2489, 2530, 2611, 2820, 2846, 2909, 3121, 3177, 3212, 3247, 3418, 3576, 3691, 3707, 3730, 3895, 3936, 3982, 4032, 4070, 4103, 4132, 4162, 4199, 4400, 4421], '2Yewdell': [926], 'J.W.': [927, 951], 'Bennink': [928], 'J.R.': [929, 2538], 'Cut': [930], 'trim:': [932], 'Generating': [933], 'ligands.': [938], 'Curr.': [939, 1548, 2317, 2604, 2693, 3319], 'Opin.': [940, 1549, 2318, 2605, 2694, 3320], '13:': [943], '13-18Crossref': [944], '(98)': [947], '3Yewdell': [950], 'Not': [952], 'dismal': [955], 'science:': [956], 'economics': [958], 'synthesis,': [961], 'folding,': [962], 'antigen': [965, 2283, 2956, 3428, 3887, 3920, 3963, 4016, 4057], 'processing.': [966], 'Trends': [967, 2626, 3263], 'Cell': [968, 1625, 3723], 'Biol.': [969], '11:': [971], '294-297Google': [972], '4Davis': [974], 'S.J.': [975], 'Ikemizu': [976], 'S.': [977, 1105, 1951, 1996, 2040, 2108, 2207, 2272, 2299, 2355, 2467, 2499, 2511, 2900, 3168, 3424, 3466, 3590, 3678, 3940, 3977, 3997, 4105, 4176, 4276, 4387], 'Evans': [978], 'E.J.': [979], 'Fugger': [980], 'L.': [981, 1584, 2134, 2550, 2856, 3222, 3382, 3946], 'Bakker': [982], 'T.R.': [983], 'van': [984, 1561, 1943, 2007, 3694, 3849, 4047, 4081], 'der': [985, 3850, 4048, 4082], 'Merwe': [986], 'P.A.': [987], 'nature': [989], 'molecular': [991, 3475], 'recognition': [992, 1121], 'cells.': [995, 1199, 1257, 1478, 1652, 2875, 4149], 'Nat.': [996, 1500, 1864, 4437], '2003;': [998, 1021, 1823, 2211, 3170], '4:': [999], '217-224Crossref': [1000], '(184)': [1003], '5Pardoll': [1006], 'D.': [1007, 1434, 1541, 1803, 2112, 2359, 2509, 2793, 2797, 2824, 2826, 2852, 2917, 3312, 3584], 'Does': [1008], 'see': [1012], 'tumors': [1013, 1933, 3039, 3471, 3665], 'self?': [1017], 'Annu.': [1018, 3741], '21:': [1022, 1115, 3688], '807-839Crossref': [1023], '(635)': [1026], 'Scholar).': [1028, 1074, 1118, 1632, 1693, 1826, 1869, 2067, 2214, 2421, 2631, 2699, 2946, 3329, 3445, 3485, 3613, 3747, 4212, 4296], 'left': [1032], 'capable': [1036], 'self': [1040], 'epitopes': [1041, 1094, 3105], 'low': [1043], 'affinity,': [1044], 'down-regulated': [1048, 3077, 3367], 'peripheral': [1050], 'tolerance': [1051, 1085], 'mechanisms': [1052, 3476], 'including': [1053], '"ignorance"': [1054], 'order': [1056], 'autoimmunity': [1059, 2751, 2789], '(6Sprent': [1060], 'J.': [1061, 1414, 1602, 1990, 2030, 2484, 2544, 2814, 2841, 2940, 3240, 3413, 3535, 3586, 3592, 3594, 3889, 3930, 3993, 4026, 4098, 4127, 4381], 'Kishimoto': [1062], 'H.': [1063, 1410, 1945, 2919, 4379, 4402], 'negative': [1067], 'selection.': [1068], '2002;': [1071, 1525, 1551, 1571, 1606, 1629, 2032, 2060, 2147, 2199, 2527, 2878, 3200, 3244, 3322, 3573, 3610, 3704, 3727, 4209], '185:': [1072], '126-135Google': [1073], 'Vaccination': [1075, 2758, 3513], 'strong': [1080, 3659], 'adjuvant': [1081, 2022], 'helps': [1082], 'overcome': [1084, 3487], 'stimulating': [1087], '"anti-self"': [1088], 'presentation': [1092], 'activated': [1096], 'dendritic': [1097, 2874, 2924], '(reviewed': [1099, 1394, 3763], 'Ref.': [1101, 2038, 2205], '7Gunzer': [1102], 'M.': [1103, 1565, 2044, 2278, 2310, 2333, 2377, 2455, 2495, 2850, 3145, 3533, 3580, 3676, 3698, 4169], 'Grabbe': [1104, 3677], 'Dendritic': [1106, 2800, 3614, 3679, 3735], 'Crit.': [1111, 3684], '133-145PubMed': [1116, 3689], 'Thus,': [1119], 'tightly': [1123], 'connected': [1124], 'schemes': [1128], 'degradation.': [1131], 'affected': [1135], 'processing': [1138], 'into': [1143, 1180, 1269, 3789, 3970], 'properties': [1149, 2590], 'individual': [1151], 'receptors': [1156], 'mediators': [1158], 'recognition.': [1161, 3607], 'Protein': [1162], 'only': [1167, 1900], '"end-of-life"': [1170], 'aimed': [1173], 'recycling': [1175], 'communicating': [1189], 'health': [1195], 'state': [1196, 1649, 3071], 'puts': [1201], 'crossroad': [1206], 'immunology,': [1210], 'indicators': [1218], 'proteomes': [1224], 'relevant': [1225], 'cancer,': [1227], 'autoimmune,': [1228], 'viral': [1230], 'knowledge': [1233], 'exploited': [1236], 'developments': [1238], 'therapeutics': [1241], 'diseases': [1244, 2725], 'ascertain': [1248, 2707], 'degraded': [1254], 'offer': [1265], 'novel': [1267, 2479], 'viewpoint': [1268], 'parts': [1271, 3501], 'often': [1276, 2656, 3667], 'overlooked': [1277], 'other': [1279, 1334, 2664], 'aspect': [1287], 'impact': [1303, 2407], 'Research': [1307], 'immunology': [1310, 1453, 2432, 4251], 'aims': [1311], 'one': [1313], 'hand': [1314, 1335], 'find': [1316], 'exploit': [1319], 'capacity': [1321], 'kill': [1327], '(immunotherapy)': [1330], 'markers': [1340], 'diagnostics,': [1342], 'prognostics,': [1343], 'targeting': [1346], 'induced': [1353, 3652], 'reject': [1355], 'augmenting': [1359], 'existing': [1361], 'weak': [1362, 1837], 'anti-tumor': [1363, 1831, 3653], 'therapeutic': [1367], 'vaccination': [1368, 1400, 1438, 1871], 'antigens.': [1371, 2316, 2390, 2625, 3262, 4206], 'Preferred': [1372], '(TSA),': [1379], 'essentially': [1385], 'absent': [1386], 'all': [1388, 2732, 2885, 4188], 'Refs.': [1396, 2353, 3180, 3765, 4135], '8Pardoll': [1397], 'D.M.': [1398, 2888], 'Therapeutic': [1399, 1870], 'cancer.': [1402, 1424, 1521, 2247, 2894, 3196, 3411], 'Clin.': [1403, 1523, 1820, 2196, 2415, 3198], '2000;': [1405, 1427, 1443, 2394, 2486, 2943, 3482, 4129], '95:': [1406], 'S44-S62Google': [1407], '9Kobayashi': [1409], 'Kennedy': [1411], 'R.': [1412, 1582, 1949, 2503, 3220, 3596, 3734, 4040], 'Lu': [1413], 'Davila': [1415], 'E.': [1416, 1418, 1432, 1511, 1539, 1957, 2276, 2799, 2828, 2858, 3186, 3310, 3864, 3907, 4000, 4108, 4172], 'Celis': [1417, 1510, 3185], 'MHC-binding': [1419], 'immunotherapeutics': [1422], 'Invest.': [1426], '29:': [1428, 1572, 3705, 4101], '105-110Google': [1429], '10Jager': [1431], 'Jager': [1433, 1540, 3311], 'Knuth': [1435, 1542, 3313], 'A.': [1436, 1543, 1588, 1611, 1795, 1986, 2300, 2546, 2901, 3169, 3226, 3314, 3394, 3537, 3578, 3709, 3861, 3866, 3900, 3978, 3989], 'Peptide': [1437], 'clinical': [1440, 1814, 1880, 2055, 3307], 'oncology.': [1441], 'Onkologie.': [1442], '23:': [1444, 1691], '410-415Google': [1445], '11Rosenberg': [1447], 'S.A.': [1448, 3541, 3952], 'Progress': [1449], 'tumour': [1452], 'Nature.': [1456, 2210, 4292], '411:': [1458], '380-384Google': [1459], '12Renkvist': [1461], 'Castelli': [1463, 1577, 3215], 'C.': [1464, 1507, 1578, 2461, 2493, 3182, 3216, 3848, 3856, 3904, 3995, 4002, 4036, 4076], 'Robbins': [1465, 3542, 3943], 'P.F.': [1466, 3543, 3944], 'Parmiani': [1467], 'G.': [1468, 1576, 1992, 2156, 2540, 3149, 3214, 3529, 3588, 4078, 4278], 'A': [1469, 1492, 1618, 1856, 1977, 2011, 2113, 2281, 2360, 3565, 3716, 3869, 4009, 4052, 4085], 'listing': [1470], 'recognized': [1475, 3285, 3877, 3921, 3964, 4017, 4058, 4092, 4146], 'Cancer': [1479, 1589, 1604, 1821, 2057, 2144, 2197, 2391, 2525, 3044, 3116, 3227, 3242, 3571, 4194, 4202], 'Immunother.': [1481, 2059], '50:': [1483, 3745, 4398], '3-15Google': [1484], '13Smyth': [1486], 'M.J.': [1487, 1851, 1998, 2264, 3139], 'Godfrey': [1488, 1852], 'D.I.': [1489, 1853], 'Trapani': [1490, 1854], 'J.A.': [1491, 1855, 2560], 'fresh': [1493, 1857], 'look': [1494, 1858], 'immunosurveillance': [1497, 1861], '2:': [1503, 1867, 4068], '293-299Google': [1504, 1868], '14Buteau': [1506, 3181], 'Markovic': [1508, 3183], 'S.N.': [1509, 3184], 'Challenges': [1512, 3187], 'effective': [1517, 3020, 3192, 3622], 'vaccines': [1519, 3194, 3737], 'Mayo': [1522, 3197], 'Proc.': [1524, 2294, 2895, 3163, 3199, 3972], '77:': [1526, 3201], '339-349Abstract': [1527, 3202], 'Full': [1528, 1530, 3203, 3205, 4155], 'Text': [1529, 1531, 3204, 3206, 4156], 'PDF': [1532, 3207, 4157], '(54)': [1535, 3210], '15Jager': [1538], 'Clinical': [1544, 3315], 'vaccine': [1546, 3317, 3569, 3598], 'trials.': [1547, 3318], '14:': [1552, 3323], '178-182Crossref': [1553, 3324], '(123)': [1556, 3327], '16Machiels': [1559, 3692], 'J.P.': [1560, 3693, 4004], 'Baren': [1562, 3695], 'Marchand': [1564, 3697], 'Peptide-based': [1566, 3699], 'vaccines.': [1568, 2524, 2839, 3701], 'Semin.': [1569, 3702], 'Oncol.': [1570, 3703], '494-502Google': [1573, 3706], '17Parmiani': [1575, 3213], 'Dalerba': [1579, 3217], 'Mortarini': [1581, 3219], 'Rivoltini': [1583, 3221, 3945], 'Marincola': [1585, 1612, 2045, 3223, 3421, 3710], 'F.M.': [1586, 1613, 2046, 3224, 3422, 3460, 3711], 'Anichini': [1587, 3225], 'peptide-based': [1592, 3230], 'vaccines:': [1593, 3231], 'What': [1594, 3232], 'have': [1595, 1779, 3233], 'we': [1596, 1600, 3234, 3238], 'achieved?': [1597, 3235], 'Where': [1598, 3236], 'going?': [1601, 3239], 'Natl.': [1603, 2295, 2896, 3164, 3241, 3973], 'Inst.': [1605, 3243], '94:': [1607, 2302, 3245], '805-818Google': [1608, 3246], '18Perez-Diez': [1610, 3708], 'Immunotherapy': [1614, 2922, 3712], 'against': [1615, 2235, 2927, 3099, 3713, 3885], 'antigenic': [1616, 3714], 'tumors:': [1617, 2051, 3715], 'game': [1619, 3717], 'lot': [1622, 3720], 'players.': [1624, 3722], 'Mol.': [1626, 2344, 2606, 3439, 3724], 'Life': [1627, 3725], 'Sci.': [1628, 2297, 2898, 3166, 3726, 3975], '59:': [1630, 3611, 3728], '230-240Google': [1631, 3729], 'desired': [1635, 3793], 'TSA': [1636, 1655, 2711], 'mutated': [1640], 'needed': [1644, 3066], 'maintain': [1646, 3068], 'transformed': [1648, 3070], 'Other': [1653], 'useful': [1654, 1724, 2634, 3274], 'result': [1664], 'loss': [1667], 'control': [1670], 'prevalent': [1671], '(19Anderson': [1675], 'G.R.': [1676], 'Stoler': [1677], 'D.L.': [1678], 'Brenner': [1679], 'B.M.': [1680], 'Cancer:': [1681], 'evolved': [1683], 'consequence': [1684], 'destabilized': [1687], 'genome.': [1688], 'Bioessays.': [1689], '1037-1046Google': [1692], 'Tumor-associated': [1694], '(TAA)': [1696], 'unique': [1702], 'larger': [1711], 'extent': [1712], 'relative': [1715], 'cells,': [1718, 2661, 2715], 'some': [1719, 1776, 1887, 3277, 3345], 'potentially': [1723, 3272], 'TAA': [1727, 2987, 3673, 4372], 'include': [1728], 'testis': [1730, 1742, 1763, 3837], 'immune-privileged': [1738], 'tissues': [1739, 1754, 2734], '(such': [1740, 1755], 'placenta)': [1744], 'differentiation': [1746, 1766, 4015], 'nonessential': [1753], 'prostate,': [1757], 'ovaries,': [1758], 'melanocytes).': [1760], 'Both': [1761], 'were': [1768, 2074, 2255, 2424, 2735, 3280, 3657, 3800, 4256, 4310, 4317, 4337, 4354], 'extensively': [1769], 'tested': [1770, 2991, 3294], 'immunotherapeutic': [1773], 'potential,': [1774], 'been': [1780, 3353], 'shown': [1781, 3354], 'induce': [1783], 'powerful': [1784], 'measurable': [1787], 'benefit': [1788], 'patients': [1791, 1817, 2869, 3034, 3650], '(20Reynolds': [1792], 'S.R.': [1793], 'Zeleniuch-Jacquotte': [1794], 'Shapiro': [1796], 'R.L.': [1797], 'Roses': [1798], 'D.F.': [1799], 'Harris': [1800, 3389], 'M.N.': [1801], 'Johnston': [1802], 'Bystryn': [1804], 'J.C.': [1805, 3091, 3123, 4006, 4042], 'Vaccine-induced': [1806], 'T-cell': [1808, 3097, 3104, 3433, 3473, 4435], 'responses': [1809, 3098], 'MAGE-3': [1811], 'correlate': [1812], 'outcome': [1815], 'melanoma.': [1819], 'Res.': [1822, 2145, 2198, 2526, 3117, 3572, 4195], '9:': [1824, 2321], '657-662Google': [1825], 'In': [1827, 3344], 'patients,': [1829, 1891], 'spontaneous': [1830, 1840], 'apparently': [1835], 'too': [1836], 'cause': [1839, 2723, 2785, 3348, 3661], 'rejection': [1841, 3662], 'tumors;': [1844], 'otherwise': [1845], 'would': [1847], 'occur': [1849], '(13Smyth': [1850], 'was': [1876, 1897, 1908, 2084, 2752, 3456, 3495, 3758, 3821], 'attempted': [1877], 'trials,': [1881, 2964], 'resulting': [1882], 'partial': [1884], 'treated': [1890], 'complete': [1894], 'regression': [1896], 'small': [1902], 'fraction': [1903], 'patients.': [1906, 3043, 3115], 'suggested': [1909], 'preferred': [1912], 'time': [1913], 'minimal': [1919], 'residual': [1920], 'stage,': [1922], 'because': [1923, 2965], 'micro-metastases': [1924], 'expected': [1926], 'responsive': [1930], 'than': [1931, 3668], 'suppressing': [1937], 'microenvironment': [1938], '(21Vermorken': [1939], 'J.B.': [1940, 2004], 'Claessen': [1941, 1987], 'A.M.': [1942, 1988], 'Tinteren': [1944], 'Gall': [1946, 1999], 'H.E.': [1947, 2000], 'Ezinga': [1948], 'Meijer': [1950, 1954, 1995, 2001], 'Scheper': [1952, 1993], 'R.J.': [1953, 1994, 3135], 'C.J.': [1955, 2002], 'Bloemena': [1956], 'Ransom': [1958], 'J.H.': [1959], 'Hanna': [1960], 'Jr.,': [1961], 'M.G.': [1962], 'Pinedo': [1963, 2005], 'H.M.': [1964, 2006], 'Active': [1965], 'II': [1970, 2013, 3522, 3563], 'III': [1973, 2026], 'colon': [1975, 2027], 'cancer:': [1976], 'randomised': [1978], 'trial.': [1979], 'Lancet.': [1980], '1999;': [1981, 2902, 3442, 3744, 4100, 4397], '353:': [1982], '345-350Google': [1983], '22Baars': [1985], 'Wagstaff': [1989], 'Giaccone': [1991], 'Schakel': [1997], 'Vermorken': [2003], 'den': [2008, 4141], 'Eertwegh': [2009], 'A.J.': [2010], 'phase': [2012], 'study': [2014], 'active': [2016], '5-FU/Leucovorin': [2020], 'therapy': [2023], 'carcinoma.': [2028], 'Br.': [2029], 'Cancer.': [2031, 3414, 4128], '86:': [2033], '1230-1234Google': [2034], 'reviewed': [2036, 2203, 2351, 3178, 4133], '23Mocellin': [2039], 'Rossi': [2041], 'C.R.': [2042], 'Lise': [2043], 'Adjuvant': [2047], 'solid': [2050, 3470], 'promise': [2053], 'application.': [2056], '51:': [2061, 3416], '583-595Crossref': [2062], '(45)': [2065], 'known': [2072, 4240, 4244, 4369], 'TAAs': [2073, 2251, 2654, 3022, 3833], 'immunological,': [2078], 'genetic,': [2079], 'proteomic': [2081, 2114, 2361], 'methods.': [2082], 'Proteomics': [2083], 'comparisons': [2087], 'between': [2088], 'using': [2093, 2141, 2443, 2600, 3760, 4373, 4410], 'two-dimensional': [2094], 'PAGE,': [2095], '(LC)-LC-mass': [2098], 'spectrometry': [2099, 4345], '(MS),': [2100], 'enhanced': [2103], 'laser': [2104], 'desorption/ionization': [2105], '(SELDI)-MS': [2106], '(24Hanash': [2107], 'Brichory': [2109, 2131, 2356], 'F.': [2110, 2132, 2357, 2497], 'Beer': [2111, 2179, 2358], 'approach': [2115, 2362, 2517, 3820, 4214], 'lung': [2120, 2184, 2367], 'markers.': [2122, 2369, 2414], 'Dis': [2123, 2370], 'Markers.': [2124, 2371], '17:': [2126, 2373], '295-300Google': [2127, 2374], '25Naour': [2129], 'F.L.': [2130], 'Beretta': [2133], 'Hanash': [2135, 2177], 'S.M.': [2136, 2178, 2592], 'Identification': [2137, 2186, 2470, 2632, 3748], 'proteomics.': [2142, 2209, 2603], 'Technol.': [2143], 'Treat.': [2146], '1:': [2148, 4210], '257-262Crossref': [2149], '(29)': [2152], '26Chen': [2155], 'Gharib': [2157], 'T.G.': [2158], 'Huang': [2159], 'C.C.': [2160], 'Thomas': [2161], 'D.G.': [2162, 2180], 'Shedden': [2163], 'K.A.': [2164], 'Taylor': [2165], 'J.M.': [2166, 3732], 'Kardia': [2167], 'S.L.': [2168, 3948], 'Misek': [2169], 'D.E.': [2170], 'Giordano': [2171], 'T.J.': [2172], 'Iannettoni': [2173], 'M.D.': [2174], 'Orringer': [2175], 'M.B.': [2176], 'Proteomic': [2181], 'adenocarcinoma:': [2185], 'highly': [2189], 'set': [2191], 'tumors.': [2195], '8:': [2200], '2298-2305Google': [2201], '27Hanash': [2206], 'Disease': [2208], '422:': [2212], '226-232Google': [2213], 'Serological': [2215, 2311, 2334], 'cloning': [2222], '(SEREX)': [2223], 'recent': [2229], 'approaches': [2230, 2433, 3772], 'antibodies': [2237], 'present': [2239, 2566], 'serum': [2242], 'people': [2244], 'inflicted': [2245], 'Some': [2248], 'this': [2253, 2972], 'way': [2254, 2705], 'selected': [2256, 3801], 'immunologic': [2259], 'tests': [2260, 3308], '(28Chen': [2261], 'Y.T.': [2262], 'Scanlan': [2263], 'Sahin': [2265, 2330], 'U.': [2266, 2298, 2306, 2331, 2899, 3167, 3976], 'Tureci': [2267, 2307], 'O.': [2268, 2308, 2329, 2501, 4167, 4274], 'Gure': [2269], 'A.O.': [2270], 'Tsang': [2271], 'Williamson': [2273], 'B.': [2274, 2459, 2911, 2915, 3087, 3129, 3582, 3909, 4143], 'Stockert': [2275], 'Pfreundschuh': [2277, 2309, 2332], 'Old': [2279], 'L.J.': [2280], 'testicular': [2282], 'aberrantly': [2284], 'cancers': [2288], 'autologous': [2291, 2871, 3923, 3966, 4019], 'antibody': [2292], 'screening.': [2293], 'Acad.': [2296, 2897, 3165, 3974], 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3266], '516-523Google': [2630, 3267], 'limited': [2639], 'number': [2642], 'obstacles.': [2644], 'First,': [2645], '"the': [2646], 'problem': [2647], 'needle': [2650], 'haystack":': [2653], 'minor': [2657], 'components': [2658], 'hidden': [2662, 4414], 'among': [2663], 'abundant': [2665], 'makes': [2668], 'demanding': [2672], 'task': [2673], '(38Shastri': [2674], 'Serwold': [2676], 'Paz': [2678], 'Reading': [2680], 'within': [2681, 4234], 'lines:': [2683], 'naturally': [2684], 'processed': [2685], '1998;': [2696, 4418, 4439], '10:': [2697], '137-144Google': [2698], 'Second,': [2700], 'there': [2701], 'no': [2703], 'simple': [2704], 'uniqueness': [2709], 'raising': [2716], 'concerns': [2718], 'administration': [2721, 3490], 'might': [2722], 'autoimmune': [2724, 2890, 2938], 'inadvertently.': [2726], 'SAGE': [2727], 'screening': [2738], 'tumors-specific': [2740], 'expression.': [2741, 4125], 'possible': [2745], 'concern': [2748], 'causing': [2750], 'justified': [2754], 'cases.': [2757], 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3912, 4007, 4045, 4079, 4109, 4173], 'colleagues': [3826], 'resulted': [3828], 'MAGE': [3839, 4121, 4181, 4205], 'melanoma': [3842, 3962], 'Melan-A/MART': [3844], 'tyrosinase': [3846, 3915], '(52Traversari': [3847], 'Bruggen': [3851, 4049, 4083], 'Luescher': [3853], 'I.F.': [3854], 'Lurquin': [3855, 4001, 4075], 'Chomez': [3857], 'Van': [3859, 3898, 3987, 4140], 'Pel': [3860, 3899, 3988], 'De': [3862, 3905, 3998, 4106, 4165, 4170], 'Plaen': [3863, 3906, 3999, 4107, 4171], 'Amar-Costesec': [3865], 'nonapeptide': [3870], 'encoded': [3871], 'MAGE-1': [3875], 'HLA-A1': [3879], 'cytolytic': [3881, 3924, 4020, 4063, 4094], 'MZ2-E.': [3888], '176:': [3893], '1453-1457Google': [3894], '53Brichard': [3896], 'V.': [3897, 3986, 4425], 'Wolfel': [3901, 3903, 3990], 'Lethe': [3908], 'Coulie': [3910, 4043, 4138], 'codes': [3917], 'HLA-A2': [3928, 4024, 4090], 'melanomas.': [3929, 4025], '1993;': [3933], '178:': [3934], '489-495Google': [3935], '54Kawakami': [3937], 'Eliyahu': [3939], 'Delgado': 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