Structural Basis for the Inhibitory Role of Tomosyn in Exocytosis

Name: Work Video:
Duration: 3 min 30 s
Ajaybabu V. Pobbati; Adelia Razeto; Matthias Böddener; Stefan Becker; Dirk Fasshauer
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2058, 2485, 2492, 2846, 2873, 3110, 3224, 3228, 3331, 3568, 3581, 4117, 4175, 4231, 4264, 4301, 4480], 'fusion.': [59, 266, 468, 559], 'Tomosyn': [60, 267, 1893], 'soluble': [63, 270, 497, 609, 1262, 2372], 'protein': [64, 271, 441, 498, 561, 618, 681, 690, 1258, 1263, 1901, 1908, 2122, 2180, 3020, 3035, 3916], 'of': [65, 99, 110, 118, 136, 181, 195, 205, 272, 306, 317, 325, 343, 388, 402, 412, 416, 472, 481, 526, 554, 563, 582, 593, 619, 784, 788, 798, 824, 831, 847, 963, 977, 1005, 1050, 1064, 1104, 1119, 1122, 1128, 1171, 1180, 1217, 1226, 1264, 1342, 1403, 1445, 1494, 1632, 1638, 1643, 1698, 1710, 1777, 1788, 1801, 1806, 1825, 1861, 1868, 1913, 2113, 2119, 2165, 2341, 2366, 2374, 2397, 2424, 2437, 2446, 2454, 2463, 2472, 2477, 2489, 2504, 2514, 2524, 2587, 2863, 2914, 2927, 3000, 3034, 3042, 3046, 3072, 3083, 3168, 3198, 3241, 3272, 3339, 3342, 3366, 3429, 3433, 3442, 3503, 3515, 3525, 3547, 3576, 3584, 3622, 3723, 3795, 3821, 3875, 3893, 3987, 3997, 4023, 4026, 4085, 4097, 4135, 4147, 4153, 4215, 4229, 4235, 4267, 4288, 4359, 4363, 4398, 4455], '130': [66, 273, 1265], 'kDa': [67, 274], 'contains': [69, 276, 500, 959, 1508, 1810], 'COOH-terminal': [71, 278, 1126, 1773, 2047, 2127], 'motif': [73, 81, 180, 280, 288, 387, 503, 1512, 1631, 1647, 1697, 1775, 2129], 'but': [74, 281, 570, 718, 1276, 1640, 1835, 2592, 3809], 'lacks': [75, 282], 'transmembrane': [77, 284, 829, 1486], 'anchor.': [78, 285], 'Its': [79, 286], 'forms': [82, 289, 1663], 'stable': [84, 291, 1524], 'core': [85, 101, 292, 308, 470, 786, 2168, 2923, 3276], 'SNARE': [86, 103, 120, 167, 198, 293, 310, 327, 374, 405, 436, 474, 513, 600, 670, 713, 791, 859, 956, 1058, 1068, 1155, 1184, 1238, 1253, 1414, 1497, 1588, 1646, 1670, 1696, 1774, 2048, 2063, 2128, 2169, 2393, 2427, 2434, 2474, 2527, 2537, 2569, 2590, 2842, 2899, 2902, 2924, 2960, 2965, 2979, 3003, 3244, 3277, 3518, 3528, 3571, 3587, 3625, 3674, 3728, 3734, 3744, 3763, 3769, 3806, 3816, 3960, 4000, 4074], 'SNAP-25.': [92, 299, 495], 'Here': [93, 300], 'we': [94, 301, 2159, 4338], 'present': [95, 302, 2160, 2565], 'crystal': [97, 304, 782, 1178, 2545, 4018], 'structure': [98, 305, 783, 1179, 1800, 1884, 2164, 2586, 3229, 3240, 3271, 4019], 'tomosyn': [102, 155, 182, 309, 362, 389, 499, 1268, 1339, 1507, 1520, 1633, 1645, 1681, 1699, 1778, 2115, 2167, 2478, 2506, 2526, 2536, 2554, 2568, 2841, 2898, 2959, 2964, 2978, 3002, 3243, 3517, 3570, 3619, 3624, 3727, 3733, 3762, 3815, 4246, 4269, 4289, 4317, 4344, 4365], 'at': [105, 312, 1513, 2352, 2388, 2416, 2499, 2918, 3007, 3115, 3118, 3749, 3776, 3785, 3939, 4212, 4282, 4355, 4461], '2.0-Å': [106, 313, 3111], 'resolution.': [107, 314], 'consists': [109, 316, 797, 1004, 1216], 'four-helical': [112, 319], 'bundle': [113, 320, 479, 803, 958, 1167, 1191, 1624, 1651], 'very': [114, 321, 1515, 2501], 'similar': [115, 142, 322, 349, 1165, 1584, 1622, 1666, 2382], 'containing': [122, 329, 1590, 2348, 2384, 2412, 2683, 3028, 3746, 3835, 3962, 4076], 'synaptobrevin.': [123, 330, 1500], 'Most': [124, 331], 'differences': [125, 332], 'found': [127, 334, 1280, 1844, 4320], 'on': [128, 335, 843, 2703, 2988, 3908, 4195, 4452, 4485], 'surface,': [130, 337], 'where': [131, 338, 1863, 4121], 'they': [132, 339, 556, 1162, 1864], 'prevented': [133, 340], 'binding': [135, 342, 1402, 1642, 1888], 'complexin.': [137, 344], 'Both': [138, 345], 'complexes': [139, 168, 346, 375, 2903, 3770, 3961, 4001], 'form': [140, 347, 525, 704, 1164, 1522, 1865], 'rates': [143, 350], 'as': [144, 351, 687, 851, 1271, 1706, 1712, 1816, 1845, 1886, 2597, 2710, 2868, 3061, 3299, 3539, 3631, 3638, 3661, 3737, 4353], 'assessed': [145, 352], 'by': [146, 353, 435, 1011, 1022, 1714, 2654, 2691, 3010, 3196, 3248, 3346, 3364, 3371, 3402, 3679, 3890, 3905, 4163, 4226, 4275], 'CD': [147, 354, 4189, 4243, 4280], 'spectroscopy.': [148, 355], 'In': [149, 356, 991, 1100, 1334, 1397, 1692, 2037, 3065, 3541, 4016, 4252, 4299], 'addition,': [150, 357, 1101, 1335, 4253], 'cannot': [152, 359, 1476], 'displace': [153, 360], 'helix': [156, 363, 483, 961, 1111, 1233, 2358, 2365, 2445, 2453, 2462, 4247], 'from': [157, 364, 485, 494, 1345, 1411, 2184, 2573, 3682, 4321, 4346], 'vice': [162, 369], 'versa,': [163, 370], 'indicating': [164, 371], 'both': [166, 373, 2885, 3607], 'represent': [169, 376], 'end': [170, 377, 841, 1832], 'products.': [171, 378], 'Moreover,': [172, 379], 'data': [173, 380, 3100, 3109], 'bank': [174, 381], 'searches': [175, 382], 'revealed': [176, 383, 793, 1186], 'highly': [184, 391, 523, 1054, 1158], 'conserved': [185, 392, 1055], 'throughout': [186, 393], 'all': [187, 394, 590, 1163], 'eukaryotic': [188, 395], 'kingdoms.': [189, 396], 'This': [190, 397, 1578, 1618, 1808], 'suggests': [191, 398, 1619], 'formation': [194, 401, 1493, 4272], 'important': [201, 408], 'for': [202, 409, 1394, 1491, 1890, 2187, 2199, 2583, 3233, 3439, 3642, 3883, 3970, 4292, 4305], 'function': [204, 411, 1798, 3370], 'tomosyn.': [206, 413, 1807, 3979, 4241], 'Inhibiting': [414], 'Exocytosis♦Journal': [415], 'Biological': [417], 'ChemistryVol.': [418], '279Issue': [419], '45PreviewDuring': [420], 'exocytosis,': [422], 'carrying': [424], 'in': [431, 511, 542, 661, 673, 838, 1048, 1281, 1447, 1627, 1833, 1858, 1910, 1976, 2175, 2534, 2543, 2566, 2644, 2860, 3025, 3105, 3534, 3551, 3557, 3633, 3791, 3826, 3926, 3942, 4064, 4081, 4219, 4278, 4308], 'aided': [434], 'proteins.': [437, 1892], 'The': [438, 469, 496, 781, 955, 1213, 1772, 2203, 2840, 2888, 2921, 2958, 2977, 3018, 3058, 3161, 3819, 3886, 3980, 4079, 4103, 4169, 4222], 'vesicle': [440, 680, 1478], '2': [443, 487, 510, 683, 691, 965, 1024, 1418, 2376, 2465, 3066, 3884, 3971, 4184], 'ternary': [457, 707, 723, 790, 826, 1579, 3743], 'brings': [460, 861], 'together': [461, 1285], 'two': [463, 492, 711, 972, 3999, 4342], 'membranes,': [464, 840], 'region': [471, 787, 1809, 4362], 'four-helix': [478, 802, 957, 1166, 1190, 1623, 1650], 'consisting': [480, 3045], 'one': [482, 960, 1017, 1232], 'each': [484, 962, 1110, 1230, 3996, 4218], 'helices': [493, 1118, 3609], 'synaptobrevin-like': [502, 1510], 'enables': [505], 'it': [506, 855, 1277, 1481, 1503, 1661, 1672, 2869, 2881, 2893], 'replace': [508], 'complex.': [514, 849, 2528, 3572, 3588, 3626, 3729], 'Full-Text': [515], 'PDF': [516, 749, 775, 919, 1328, 1383, 1549, 1612, 1737, 1934, 2152, 2248, 2274, 2304, 2332, 2631, 2750, 2776, 2806, 2834, 3293, 3709, 4056], 'Open': [517], 'Access': [518], 'Synaptic': [519], 'exocytosis': [520, 2176], 'controlled': [524], 'trafficking': [528], 'evolved': [529], 'rapidly': [531], 'Neurotransmitter-loaded': [538], 'reside': [541], 'ready-to-fuse': [544], 'state': [545], 'close': [546, 866], 'membrane.': [550], 'undergo': [557], 'rapid': [558], 'Many': [560], 'components': [562], 'machinery': [566, 586, 2064], 'have': [567, 1853, 1972, 2207], 'been': [568, 1854, 1974, 2208, 2594, 4351], 'identified,': [569], 'exact': [572], 'roles': [573], 'only': [575, 1780, 1837, 2520], 'coming': [577], 'light.': [579, 4149], 'Several': [580], 'factors': [581, 1251], 'common': [588], 'fusion': [591, 664, 872, 1479], 'events': [592], 'secretory': [595], 'pathway.': [596], 'Among': [597], 'them': [598, 1875], '1The': [601], 'abbreviations': [602], 'used': [603, 2582, 3438, 4261, 4304], 'are:': [604], 'SNARE,': [605], 'SNAP': [606], 'receptor;': [607], 'SNAP,': [608], 'N-ethylmaleimide-sensitive': [610], 'factor': [611, 1393, 3230], '(NSF)': [612], 'attachment': [613], 'protein;': [614], 'SNAP-25,': [615, 702, 1015, 1289], 'synaptosomal': [616], 'associated': [617], '25': [620, 3940], 'kDa;': [621], 'Cpx,': [622], 'complexin;': [623], 'Syb,': [624], 'synaptobrevin,': [625, 1639], 'Syx,': [626], 'syntaxin,': [627], 'FRET,': [628, 3796], 'fluorescence': [629, 3877, 3954, 3981, 4065, 4083, 4125], 'resonance': [630, 3955], 'energy': [631, 3956], 'transfer;': [632], 'OG,': [633], 'Oregon': [634, 3780, 3845], 'Green;': [635], 'TR,': [636], 'Texas': [637, 3753, 3850, 4086], 'Red;': [638], 'Lgl,': [639], 'lethal(2)giant': [640, 1902], 'larvae;': [641], 'MES,': [642, 3055], '4-morpholineethanesulfonic': [643], 'acid;': [644], 'PBS,': [645], 'phosphate-buffered': [646], 'saline;': [647], 'r.m.s.d.,': [648], 'root': [649], 'mean': [650], 'square': [651], 'deviation.': [652], 'play': [657], 'catalytic': [659], 'role': [660, 2174], 'process.': [665], 'Best': [666], 'characterized': [667], 'involved': [672, 1909], 'exocytosis.': [675, 1396], 'They': [676, 1841, 2579, 3091], 'include': [677], '(also': [684, 1814], 'referred': [685], 'vesicle-associated': [688], '(VAMP': [692], '2))': [693], 'which': [703, 834, 1221, 1389, 1474, 1628, 2197, 2509], 'membranes.': [712], 'monomers': [714, 2917], 'mostly': [716, 989], 'unstructured': [717, 2533], 'upon': [719, 3721, 3811], 'assembly': [720, 823, 860, 1239, 2913], 'major': [725], 'conformational': [726], 'changes': [727], 'occur': [728], '(1Fasshauer': [729], 'D.': [730, 732, 756, 807, 926, 939, 1028, 1078, 1195, 1556, 1597, 1599, 1722, 1724, 1752, 2017, 2087, 2137, 2139, 2212, 2229, 2257, 2293, 2315, 2321, 2603, 2714, 2731, 2759, 2795, 2817, 2823, 2942, 3698, 4041], 'Bruns': [731, 1598, 1723, 1751, 2138], 'Shen': [733], 'B.': [734, 1422], 'Jahn': [735, 761, 808, 1029, 1083, 1198, 1561, 1600, 1725, 2140, 2217, 2236, 2260, 2288, 2318, 2604, 2719, 2738, 2762, 2790, 2820, 2947, 3693], 'R.': [736, 762, 809, 906, 1030, 1084, 1199, 1562, 1601, 1726, 1748, 2141, 2218, 2237, 2261, 2263, 2289, 2317, 2319, 2605, 2720, 2739, 2763, 2765, 2791, 2819, 2821, 2948, 3311, 3407, 3694], 'Brünger': [737, 763, 1081, 1559, 2215, 2717, 2945], 'A.T.': [738, 764, 811, 1032, 1082, 1560, 2216, 2607, 2620, 2718, 2946, 3282], 'J.': [739, 765, 878, 893, 1430, 1454, 1602, 1727, 1754, 2001, 2073, 2142, 2238, 2264, 2291, 2294, 2322, 2621, 2740, 2766, 2793, 2796, 2824, 3254, 3283, 3350, 3460, 3696, 3699, 4047, 4402, 4435], 'Biol.': [740, 766, 946, 1204, 1432, 1603, 1728, 1926, 1946, 2003, 2027, 2075, 2097, 2143, 2239, 2265, 2295, 2323, 2622, 2741, 2767, 2797, 2825, 3184, 3214, 3259, 3284, 3316, 3352, 3387, 3412, 3475, 3700], 'Chem.': [741, 767, 1604, 1729, 2144, 2240, 2266, 2296, 2324, 2623, 2742, 2768, 2798, 2826, 3285, 3701], '1997;': [742, 768, 3153, 3493], '272:': [743, 769], '4582-4590Abstract': [744], 'Full': [745, 747, 771, 773, 915, 917, 1324, 1326, 1379, 1381, 1545, 1547, 1608, 1610, 1733, 1735, 1930, 1932, 2148, 2150, 2244, 2246, 2270, 2272, 2300, 2302, 2328, 2330, 2627, 2629, 2746, 2748, 2772, 2774, 2802, 2804, 2830, 2832, 3289, 3291, 3705, 3707, 4052, 4054], 'Text': [746, 748, 772, 774, 916, 918, 1325, 1327, 1380, 1382, 1546, 1548, 1609, 1611, 1734, 1736, 1931, 1933, 2149, 2151, 2245, 2247, 2271, 2273, 2301, 2303, 2329, 2331, 2628, 2630, 2747, 2749, 2773, 2775, 2803, 2805, 2831, 2833, 3290, 3292, 3706, 3708, 4053, 4055], 'PubMed': [750, 776, 816, 887, 900, 920, 933, 950, 1037, 1095, 1150, 1208, 1329, 1384, 1436, 1463, 1550, 1573, 1613, 1738, 1767, 1935, 1950, 1965, 1990, 2007, 2032, 2079, 2102, 2153, 2223, 2249, 2275, 2305, 2333, 2612, 2632, 2725, 2751, 2777, 2807, 2835, 2953, 3156, 3189, 3219, 3264, 3294, 3320, 3356, 3392, 3416, 3480, 3496, 3710, 4057, 4386, 4419, 4446], 'Scopus': [751, 777, 817, 888, 901, 921, 934, 951, 1038, 1096, 1151, 1209, 1330, 1385, 1437, 1464, 1551, 1574, 1614, 1739, 1768, 1936, 1951, 1966, 2008, 2033, 2080, 2103, 2154, 2224, 2250, 2276, 2306, 2334, 2613, 2633, 2726, 2752, 2778, 2808, 2836, 2954, 3157, 3190, 3220, 3265, 3295, 3321, 3357, 3393, 3417, 3481, 3497, 3711, 4058, 4387, 4420], '(167)': [752], 'Google': [753, 779, 819, 890, 903, 923, 936, 953, 1040, 1098, 1153, 1211, 1332, 1387, 1439, 1466, 1553, 1576, 1616, 1741, 1770, 1938, 1953, 1968, 1991, 2010, 2035, 2082, 2105, 2156, 2226, 2252, 2278, 2308, 2336, 2615, 2635, 2728, 2754, 2780, 2810, 2838, 2956, 3159, 3192, 3222, 3267, 3297, 3323, 3359, 3395, 3419, 3466, 3483, 3499, 3713, 4060, 4389, 4422, 4447], 'Scholar,': [754, 891, 904, 924, 937, 1554, 1742, 1939, 1954, 1992, 2083, 2227, 2253, 2279, 2309, 2616, 2729, 2755, 2781, 2811, 4423], '2Fasshauer': [755], 'Otto': [757], 'H.': [758, 1299, 1307, 1311, 1354, 1362, 1366, 1960], 'Eliason': [759, 2213, 2715, 2943], 'W.K.': [760, 2214, 2716, 2944], '28036-28041Abstract': [770], '(280)': [778], 'Scholar).': [780, 820, 954, 1041, 1099, 1154, 1212, 1333, 1440, 1467, 1577, 1617, 1771, 1969, 2036, 2106, 2157, 2636, 2839, 2957, 3160, 3420, 3714, 4061, 4390], 'an': [799, 1187, 1391, 2493, 3080, 3333, 3984], 'elongated,': [800], 'parallel': [801], '(3Sutton': [804, 1025, 2600], 'R.B.': [805, 1026, 1080, 1558, 2601], 'Fasshauer': [806, 1027, 1194, 1596, 1721, 2136, 2256, 2292, 2320, 2602, 2758, 2794, 2822, 3697], 'Brunger': [810, 1031, 2606, 2619, 3281], 'Nature.': [812, 1033, 1146, 2608], '1998;': [813, 1034, 1092, 1321, 1376, 1542, 1570, 1987, 2220, 2609, 2722, 2950, 4416], '395:': [814, 1035, 2610], '347-353Crossref': [815, 1036, 2611], '(1916)': [818, 1039, 2614], 'Consequently,': [821], 'complex,': [827, 1671], 'regions': [830], 'SNAREs,': [833], 'originally': [836], 'located': [837], 'opposing': [839, 863], 'up': [842], 'same': [845, 3635], 'side': [846, 3544, 3657], 'Therefore,': [850], 'general': [853], 'principle,': [854], 'membranes': [864, 1241], 'apposition,': [867], 'perhaps': [868], 'directly': [869, 2059], 'causing': [870], '(for': [873, 1919], 'reviews,': [874, 1920], 'see': [875, 1921], 'Refs.': [876, 1922], '4Rizo': [877], 'Sudhof': [879, 909, 1455, 4044], 'T.C.': [880, 910, 1456, 2287, 2789, 3692, 4045], 'Nat.': [881, 1202, 1457, 1944, 3314, 3410], 'Rev.': [882, 943, 1458], 'Neurosci.': [883, 1459], '2002;': [884, 897, 1205, 1460, 2029, 2099, 2325, 2827, 3186, 4049], '3:': [885, 1461], '641-653Crossref': [886, 1462], '(435)': [889, 1465], '5Rettig': [892], 'Neher': [894], 'E.': [895, 2023, 2093, 3203, 3209, 4039], 'Science.': [896], '298:': [898], '781-785Crossref': [899], '(275)': [902], '6Jahn': [905], 'Lang': [907, 1594, 1719, 2134], 'T.': [908, 1301, 1303, 1305, 1356, 1358, 1360, 1595, 1720, 2135, 4433], 'Cell.': [911, 2028, 2098], '2003;': [912, 930, 947, 1605, 1730, 1947, 1962, 2145, 2624, 3216, 3286], '112:': [913], '519-533Abstract': [914], '(1230)': [922], '7Fasshauer': [925], 'Biochim.': [927], 'Biophys.': [928], 'Acta.': [929], '1641:': [931], '87-97Crossref': [932], '(93)': [935], '8Ungar': [938], 'Hughson': [940], 'F.M.': [941], 'Annu.': [942], 'Cell': [944, 1431, 1945, 2002, 2074], 'Dev.': [945], '19:': [948], '493-517Crossref': [949], '(232)': [952], '1a,': [968, 1288], 'whereas': [969], 'contributes': [971], 'helices.': [973, 3604], 'Over': [974], 'length': [976, 3948, 4207, 4266], 'coiled-coil': [979], 'bundle,': [980], '16': [981], 'heptad': [982, 998, 3505], 'repeat': [983, 999, 1907, 3506], 'layers': [984, 1107, 3507, 3524], 'formed': [986, 1626], 'hydrophobic.': [990], 'center,': [993], 'however,': [994], 'buried': [996], 'hydrophilic': [997], 'layer': [1000, 1046, 3535], '("0-layer")': [1001], 'exists.': [1002], 'three': [1006, 4315], 'glutamine': [1007], 'residues': [1008, 2344, 2360, 2369, 2378, 2401, 2406, 2441, 2449, 2457, 2530, 3593], '(Q),': [1009], 'contributed': [1010, 1021], 'arginine': [1018], 'residue': [1019], '(R),': [1020], 'Sequence': [1042, 4285], 'comparison': [1043], 'showed': [1044], 'residues,': [1047, 1067], 'particular': [1049], '0-layer,': [1052], 'across': [1056], 'family.': [1059], 'According': [1060], 'distribution': [1063], '0-layer': [1066], 'were': [1070, 1130, 2182, 2431, 2531, 2540, 2571, 2580, 2642, 2662, 2688, 2904, 3005, 3103, 3113, 3139, 3425, 3437, 3454, 3771, 3839, 3856, 3923, 3937, 3965, 4106, 4167, 4192, 4210, 4290, 4319, 4369, 4393, 4477], 'therefore': [1071, 1470, 2109], 'classified': [1072], 'Q-': [1074], 'R-SNAREs': [1076], '(9Fasshauer': [1077], 'Sutton': [1079, 1557], 'Proc.': [1085, 1563, 1757, 4409], 'Natl.': [1086, 1564, 1758, 4410], 'Acad.': [1087, 1565, 1759, 4411], 'Sci.': [1088, 1566, 1760, 4412], 'U.': [1089, 1567, 1746, 1756, 1761, 4413], 'S.': [1090, 1197, 1309, 1364, 1568, 1762, 1958, 2235, 2259, 2281, 2311, 2737, 2761, 2783, 2813, 3686, 4414, 4429], 'A.': [1091, 1315, 1370, 1569, 1763, 1924, 1983, 2015, 2085, 3309, 3378, 3405, 4415], '95:': [1093, 1571, 4417], '15781-15786Crossref': [1094, 1572], '(752)': [1097, 1575], 'presence': [1103, 2862], 'other': [1105, 1250, 1891, 4316], 'asymmetric': [1106], 'allowed': [1108], 'assigning': [1109], 'different': [1114], 'subfamily.': [1115], 'Accordingly,': [1116], 'NH2-': [1124], 'halves': [1127], 'named': [1131], 'Qa,': [1132], 'Qb,': [1133], 'Qc': [1135], 'helix,': [1136, 2966], 'respectively': [1137], '(10Bock': [1138], 'J.B.': [1139], 'Matern': [1140], 'H.T.': [1141], 'Peden': [1142], 'A.A.': [1143, 3376], 'Scheller': [1144, 1316, 1371, 1428, 1539], 'R.H.': [1145, 1317, 1372, 1429, 1540], '2001;': [1147, 2267, 2769, 3261], '409:': [1148], '839-841Crossref': [1149], '(524)': [1152], 'conserved,': [1159], 'suggesting': [1160], 'structures.': [1168], 'A': [1169, 1255, 2577], 'proof': [1170], 'principle': [1173], 'was': [1174, 1269, 1278, 1469, 1504, 2108, 2479, 2519, 2558, 2852, 2882, 2890, 2981, 3022, 3037, 3194, 3246, 3329, 3616, 3719, 3765, 3797, 3801, 3879, 3888, 3903, 3917, 3968, 3990, 4005, 4013, 4066, 4070, 4090, 4114, 4172, 4224, 4250, 4260, 4273, 4467], 'accomplished': [1175], 'when': [1176, 3799, 4068], 'late': [1182], 'endosomal': [1183, 1214], 'almost': [1188], 'identical': [1189], '(11Antonin': [1192], 'W.': [1193, 2231, 2285, 2733, 2787, 3150, 3690], 'Becker': [1196], 'Schneider': [1200], 'T.R.': [1201], 'Struct.': [1203, 3315, 3351, 3411], '9:': [1206], '107-111Crossref': [1207], '(209)': [1210], 'four': [1218], 'independent': [1219], 'proteins,': [1220, 1862], 'relatively': [1223, 2896], 'distant': [1224], 'homologues': [1225], 'neuronal': [1228, 2426, 3586], 'counterparts,': [1229], 'contributing': [1231], 'bundle.': [1236], 'Since': [1237], 'key': [1244], 'reaction': [1245, 3887, 4223], 'secretion,': [1248], 'many': [1249], 'regulate': [1252], 'function.': [1254], 'candidate': [1256], 'regulatory': [1257], 'tomosyn,': [1260, 1473, 2040], 'kDa.': [1266], 'Initially,': [1267, 3854, 4112], 'discovered': [1270, 1975], '1a-binding': [1274], 'protein,': [1275], 'also': [1279, 1973, 2581], 'larger': [1283], 'putative': [1292], 'sensor': [1294], 'synaptotagmin': [1295], '(12Fujita': [1296, 1351], 'Y.': [1297, 1313, 1319, 1352, 1368, 1374, 1538, 1750, 1985], 'Shirataki': [1298, 1353], 'Sakisaka': [1300, 1355], 'Asakura': [1302, 1357], 'Ohya': [1304, 1359], 'Kotani': [1306, 1361], 'Yokoyama': [1308, 1363], 'Nishioka': [1310, 1365], 'Matsuura': [1312, 1367], 'Mizoguchi': [1314, 1369], 'Takai': [1318, 1373], 'Neuron.': [1320, 1375, 1541, 4048], '20:': [1322, 1377], '905-915Abstract': [1323, 1378], '(230)': [1331, 1386], 'experiments': [1336, 1399, 4244], 'suggested': [1337, 1471, 1713], 'capable': [1341], 'releasing': [1343], 'its': [1346, 1514, 1689, 2172, 3199, 3683], 'high-affinity': [1347, 3666], 'interaction': [1348, 3536], 'munc18': [1350, 1404, 1446], 'Scholar),': [1388, 3268, 3467, 3484], 'essential': [1392], 'vitro': [1398], 'imply': [1400], 'prevents': [1408], 'forming': [1412, 2395], '(13Yang': [1421], 'Steegmaier': [1423], 'M.': [1424, 1981, 2233, 2255, 2313, 2735, 2757, 2815, 3207, 4043], 'Gonzalez': [1425], 'Jr.,': [1426], 'L.C.': [1427], '2000;': [1433, 1927, 2297, 2799, 3702], '148:': [1434], '247-252Crossref': [1435], '(228)': [1438], 'Nevertheless,': [1441], 'molecular': [1443, 3249, 4021], 'action': [1444], 'vivo': [1448], 'still': [1450], 'heavily': [1451], 'debated': [1452], '(4Rizo': [1453], 'itself': [1475], 'support': [1477], 'because': [1480], 'does': [1482, 1641, 3565], 'not': [1483, 2541, 2871, 3566, 3810, 4478], 'possess': [1484], 'region,': [1487], 'might': [1488, 1682, 1700], 'activate': [1489], 'fusion-active': [1496], 'However,': [1501, 2517], 'later': [1502], 'recognized': [1505, 4394], 'COOH': [1516, 2502], 'terminus': [1517, 2503], 'allows': [1519], '(14Masuda': [1531], 'E.S.': [1532], 'Huang': [1533], 'B.C.': [1534], 'Fisher': [1535], 'J.M.': [1536], 'Luo': [1537], '21:': [1543], '479-480Abstract': [1544], '(56)': [1552], '9Fasshauer': [1555], 'exhibits': [1581], 'biophysical': [1582], 'properties': [1583], '(15Hatsuzawa': [1592, 1717, 2132], 'K.': [1593, 1718, 1994, 2066, 2133], '278:': [1606, 1731, 2146, 2625, 3287], '31159-31166Abstract': [1607, 1732, 2147], '(102)': [1615, 1740, 2155, 2277, 2779], 'takes': [1634], 'over': [1635, 1656], 'position': [1637, 2353, 2389, 2417, 3750, 3777], 'establish': [1648], 'tightly': [1654], 'structured': [1655], 'entire': [1658], 'sequence?': [1659], 'If': [1660], 'indeed': [1662], 'synaptobrevin-containing': [1669, 2589, 2922], 'then': [1674], 'structurally': [1675], 'rather': [1676], 'difficult': [1677], 'envision': [1679], 'how': [1680], 'be': [1683, 1701, 3677], 'able': [1684, 2057], 'transfer': [1686, 3957], 'partner': [1690], 'SNAREs.': [1691], 'case,': [1694], 'better': [1702], 'suited': [1703], 'act': [1705], 'competitive': [1708], 'inhibitor': [1709], 'overexpression': [1715], 'studies': [1716], '16Yizhar': [1743], 'O.': [1744], 'Matti': [1745], 'Melamed': [1747], 'Hagalili': [1749], 'Rettig': [1753], 'Ashery': [1755], '2004;': [1764, 4443], '101:': [1765], '2578-2583Crossref': [1766], '(86)': [1769], 'domain': [1776, 2373, 2396, 2436, 2476], 'comprises': [1779], 'small': [1782], 'portion,': [1783], 'less': [1784], 'than': [1785], '10': [1786, 3894], 'kDa,': [1787], 'large': [1790, 1803], 'protein.': [1791], 'Not': [1792], 'much': [1793], 'known': [1795, 1815], 'about': [1796, 1826, 4031], 'NH2-terminal': [1804, 4361], 'part': [1805], 'several': [1811, 1846], 'WD': [1812, 1821, 1906, 4391], 'repeats': [1813, 1822, 4392], 'Trp-Asp': [1817, 1834], 'or': [1818, 2699, 2877, 3760, 3849, 3978, 4240], 'WD40': [1819], 'repeat).': [1820], 'stretches': [1824], '40': [1827], 'amino': [1828, 2512], 'acids': [1829, 2513], 'typically': [1831, 1843], 'exhibit': [1836], 'limited': [1838], 'sequence': [1839], 'conservation.': [1840], 'tandemly': [1847], 'repeated': [1848], 'units.': [1849], 'Such': [1850], 'repetitive': [1851], 'segments': [1852], 'shown': [1855, 3538, 3550, 3556, 3630, 3660, 3825], 'exist': [1857], 'number': [1860], 'blades': [1867], 'β-propeller': [1870], 'structure;': [1871], 'most': [1872], 'prominent': [1873], 'among': [1874], 'β-transducin.': [1877], 'now': [1880], 'accepted': [1881], 'serves': [1885], 'site': [1889], 'homologous': [1895], 'Drosophila': [1898], 'tumor': [1899], 'suppressor': [1900], 'larvae': [1903], '(Lgl),': [1904], 'establishment': [1912], 'epithelial': [1914], 'cell': [1915], 'polarity': [1916], 'development': [1918], '17Wodarz': [1923], 'Curr.': [1925], '10:': [1928], 'R624-R626Abstract': [1929], '(82)': [1937], '18Justice': [1940], 'N.J.': [1941], 'Jan': [1942], 'Y.N.': [1943], '5:': [1948], '273-274Crossref': [1949], '(6)': [1952], '19Humbert': [1955], 'P.': [1956, 2000, 2072, 3179, 3205, 4406, 4439], 'Russell': [1957], 'Richardson': [1959], 'BioEssays.': [1961], '25:': [1963], '542-553Crossref': [1964], '(233)': [1967], 'Lgl': [1970, 2041, 2055, 2121, 4367], 'homologs': [1971, 2042, 4287, 4345], 'yeast': [1977], '(Sro7p,': [1978], 'Sro77p)': [1979], '(20Kagami': [1980], 'Toh-e': [1982], 'Matsui': [1984], 'Genetics.': [1986], '149:': [1988], '1717-1727Crossref': [1989], '21Lehman': [1993], 'Rossi': [1995, 2067], 'G.': [1996, 2068], 'Adamo': [1997, 2069], 'J.E.': [1998, 2070], 'Brennwald': [1999, 2024, 2071, 2094], '1999;': [2004, 2076, 2241, 2743, 3317, 3353, 3389, 3413, 3477], '146:': [2005, 2077], '125-140Crossref': [2006, 2078], '(175)': [2009, 2081], 'Scholar)': [2011, 3193, 3223, 3298, 3324, 3360, 3396, 4448], 'mammals': [2013], '(22Musch': [2014], 'Cohen': [2016, 2086], 'Yeaman': [2018, 2088], 'C.': [2019, 2089], 'Nelson': [2020, 2090], 'W.J.': [2021, 2091], 'Rodriguez-Boulan': [2022, 2092], 'P.J.': [2025, 2095, 3175, 3459], 'Mol.': [2026, 2096], '13:': [2030, 2100], '158-168Crossref': [2031, 2101], '(162)': [2034, 2104], 'contrast': [2038], 'appear': [2043], 'lack': [2045], 'motif.': [2049], 'Nevertheless': [2050], 'Sro7p,': [2051], 'Sro77p,': [2052], 'mammalian': [2054], 'interact': [2060], '(21Lehman': [2065], '22Musch': [2084], 'speculated': [2110], 'family': [2116, 2123], 'derivatives': [2118], 'acquired': [2125], 'evolution': [2131], 'Here,': [2158], 'insights': [2161], 'possible': [2173], 'Protein': [2177, 2637], 'Constructs—All': [2178], 'recombinant': [2179], 'fragments': [2181, 2428, 2564], 'derived': [2183, 2572], 'cDNAs': [2185], 'encoding': [2186], 'rat': [2188], 'subcloned': [2191], 'pET28a': [2194], 'vector': [2195], '(Novagen),': [2196], 'encodes': [2198], 'thrombin-cleavable': [2200], 'amino-terminal': [2201], 'His6-tags.': [2202], 'following': [2204, 4323], 'expression': [2205], 'constructs': [2206], 'described': [2209, 2711], 'before': [2210, 4483], '(23Fasshauer': [2211, 2713, 2941], 'Biochemistry.': [2219, 2721, 2949], '37:': [2221, 2723, 2951], '10354-10362Crossref': [2222, 2724, 2952], '(208)': [2225, 2727, 2955], '24Fasshauer': [2228, 2730], 'Antonin': [2230, 2284, 2732, 2786, 3689], 'Margittai': [2232, 2312, 2734, 2814], 'Pabst': [2234, 2258, 2736, 2760], '274:': [2242, 2744], '15440-15446Abstract': [2243, 2745], '(244)': [2251, 2753], '25Margittai': [2254, 2756], 'Langen': [2262, 2316, 2764, 2818], '276:': [2268, 2770, 3154], '13169-13177Abstract': [2269, 2771], '26Pabst': [2280, 2782], 'Hazzard': [2282, 2784, 3687], 'J.W.': [2283, 2785, 3688], 'Südhof': [2286, 2788, 3691], 'Rizo': [2290, 2792, 3695, 4046], '275:': [2298, 2800, 3703], '19808-19818Abstract': [2299, 2801, 3704], '(155)': [2307, 2809, 3712], '27Pabst': [2310, 2812], 'Vainius': [2314, 2816], '277:': [2326, 2828, 3494], '7838-7848Abstract': [2327, 2829], '(106)': [2335, 2837], 'Scholar):': [2337], 'cysteine-free': [2339], 'variant': [2340, 2347, 2488], 'SNAP-25A': [2342, 2447, 2455], '(SNAP-25,': [2343], '1–206),': [2345], 'single': [2350, 2386, 2414, 3837], 'cysteine': [2351, 2387, 2415, 3838], '200': [2354, 2991, 3751], '(SNAP-25200),': [2355], 'first': [2357, 2444, 4129], '(Sn1,': [2359, 2448], '1–83),': [2361, 2936], 'second': [2364, 2452, 4141], 'SNAP-25a': [2367], '(Sn2,': [2368, 2456], '120–206);': [2370], '(Syb,': [2377], '1–96)': [2379], 'fragment': [2383, 2471, 2507, 2555, 2843, 4257], '61': [2390], '(Syb61);': [2391], '(SyxH3,': [2400, 2440], '180–262);': [2402], 'complexin': [2403, 2410, 3577], '1': [2404, 2411, 2677, 2680, 3032, 3040, 3578, 3898, 4216], '(Cpx,': [2405], '1–134)': [2407], '39': [2418, 3778], '(Cpx39).': [2419], 'For': [2420, 2547, 3099, 3605, 3612, 3953, 4242], 'crystallization,': [2421], 'shortened': [2422, 2470], 'versions': [2423], '(introduced': [2429], 'above)': [2430], 'generated:': [2432], 'complex-forming': [2435, 2475], '1A': [2439], '188–259),': [2442, 2969], '7–83),': [2450, 2972], '142–204),': [2458], '(residues': [2466, 2481, 2556, 2929, 2932, 2935, 2939, 2968, 2971, 2975, 4248, 4258], '30–89).': [2467], 'Likewise,': [2468], 'constructed': [2480], '1050–1108,': [2482], 'numbering': [2483], 'according': [2484, 4116, 4174], 'm-splice': [2487], 'tomosyn).': [2490], 'Due': [2491], 'erroneous': [2494], 'DNA': [2495], 'primer': [2496], 'frameshift': [2498], 'occurred,': [2508], 'added': [2510, 3880], '32': [2511], 'vector-derived': [2515], 'sequence.': [2516], 'detected': [2521, 2542], 'after': [2522, 2911, 3068, 3096, 3992, 4008, 4161], 'crystallization': [2523], 'These': [2529, 3767], 'probably': [2532], 'structure.': [2546], 'spectroscopic': [2549], 'investigations': [2550], 'slightly': [2552], 'longer': [2553], '1051–1116)': [2557, 4249], 'used.': [2559, 4251], 'Note': [2560, 3730], 'spliceform': [2576, 2598], '(P13795-2).': [2578], 'determine': [2584], 'had': [2593, 4349], 'erroneously': [2595], 'labeled': [2596, 3748, 3775, 3840, 3915, 3963], 'B': [2599, 3446], '28Ernst': [2617], 'J.A.': [2618, 3280], '8630-8636Abstract': [2626, 3288], '(67)': [2634, 3296], 'Expression': [2638], 'Purification—All': [2640], 'expressed': [2643], 'Escherichia': [2646], 'coli': [2647], 'strain': [2648], 'BL21': [2649], '(DE3)': [2650], 'initially': [2652], 'purified': [2653, 2690, 2905, 2916, 2983], 'Ni2+-nitrilotriacetic': [2655, 2848], 'acid': [2656, 2849], 'affinity': [2657], 'chromatography.': [2658], 'After': [2659, 3897], 'elution,': [2660], 'His6-tags': [2661], 'removed': [2663, 3904], 'using': [2664, 2695, 2854, 2906, 2984, 3132, 3269, 3306, 3841, 3950, 3983, 4092, 4201, 4293, 4470], 'thrombin': [2665], 'overnight': [2667, 2912], 'dialysis': [2668], 'standard': [2670, 3026, 4471], 'buffer': [2671, 3027, 3861], '(20': [2672, 3862], 'mm': [2673, 2678, 2681, 2685, 2856, 3030, 3050, 3054, 3863, 3869, 3895], 'Tris,': [2674], 'pH': [2675, 2858, 3056, 3866], '7.4,': [2676, 2859, 3867], 'EDTA,': [2679, 2857], 'dithiothreitol)': [2682], '50': [2684, 3049, 3053], 'NaCl.': [2686, 3031], 'Proteins': [2687, 4209], 'further': [2689, 2982], 'ion': [2692], 'exchange': [2693], 'chromatography': [2694, 2987], 'Mono': [2697, 2700, 2875, 2878, 2908], 'Q': [2698, 2876, 2909], 'S': [2701, 2879], 'column': [2702, 2910, 2993], 'Δkta': [2705], 'system': [2706], '(Amersham': [2707, 2994], 'Biosciences)': [2708], 'essentially': [2709], 'previously': [2712], 'bound': [2844, 3580], 'strongly': [2845], 'matrix': [2850], 'eluted': [2853], '100': [2855, 3029, 3116, 3868], '5': [2864, 3097, 4009], 'm': [2865], 'urea.': [2866], 'Furthermore,': [2867, 4337], 'did': [2870], 'bind': [2872, 3567], 'column,': [2880], 'run': [2883], 'through': [2884], 'columns.': [2887], 'flow-through': [2889], 'collected,': [2891], 'contained': [2894, 2962], 'pure': [2897], 'fragment.': [2900, 4270], 'All': [2901, 3935], '4': [2919, 3166], '°C.': [2920], 'consisted': [2926, 3338], 'Syb': [2928, 3599, 3615, 3656, 3673, 3759, 3805, 3977, 4239, 4256], '1–96),': [2930], 'SyxH3': [2931, 2967, 3974, 4236], '180–262),': [2933], 'Sn1': [2934, 2970], 'Sn2': [2938, 2974], '120–206)': [2940], '142–204).': [2976], 'size': [2985, 3082, 3095], 'exclusion': [2986], 'Superdex': [2990], 'HR-10/30': [2992], 'Biosciences).': [2995], 'Crystallization': [2996], 'Data': [2998, 3138], 'Collection—Crystals': [2999], 'obtained': [3006], '20': [3008], '°C': [3009, 3941, 4482], 'vapor': [3012], 'diffusion': [3013], 'technique': [3014], 'hanging': [3016, 3074], 'drops.': [3017], 'initial': [3019, 3334], 'concentration': [3021, 4214], '≈6.5': [3023], 'mg/ml': [3024], 'μl': [3033, 3041], 'solution': [3036, 3044], 'mixed': [3038, 3772, 3802, 4071, 4211], 'well': [3043], '30%': [3047], '(±)-2-methyl-2,4-pentanediol,': [3048], 'CaCl2,': [3051], '6.0.': [3057], 'crystals': [3059, 3102], 'grew': [3060], 'clustered,': [3062], 'thin': [3063], 'plates.': [3064], 'days,': [3067], 'streak': [3070], 'seeding': [3071], 'preequilibrated': [3073], 'drops': [3075], 'single,': [3076], 'thicker': [3077], 'plates': [3078], 'average': [3081], '0.1': [3084], '×': [3085, 3087, 4181, 4185, 4187], '0.4': [3086], '0.7': [3088], 'mm3': [3089], 'appeared.': [3090], 'reached': [3092], 'maximal': [3094], 'days.': [3098], 'collection': [3101], 'flashed-cooled': [3104], 'liquid': [3106], 'nitrogen.': [3107], 'Diffraction': [3108], 'resolution': [3112], 'collected': [3114], 'K': [3117], 'European': [3120], 'Molecular': [3121], 'Biology': [3122], 'Laboratory': [3123], 'BW7A': [3124], 'synchrotron': [3125], 'beam-line': [3126], '(Deutsche': [3127], 'Electronen': [3128], 'Synchrotron,': [3129], 'Hamburg,': [3130], 'Germany),': [3131], 'marccd': [3134], 'image': [3135], 'plate': [3136], 'scanner.': [3137], 'integrated': [3140], 'DENZO': [3142], 'scaled': [3144], 'SCALEPACK': [3146], '(29Otwinowski': [3147], 'Z.': [3148], 'Minor': [3149], 'Methods': [3151, 3491], 'Enzymol.': [3152, 3492], '307-326Crossref': [3155], '(38573)': [3158], 'Collaborative': [3162], 'Computational': [3163], 'Program': [3164], 'Number': [3165], 'suite': [3167], 'programs': [3169], '(30Winn': [3170], 'M.D.': [3171], 'Ashton': [3172], 'A.W.': [3173], 'Briggs': [3174, 3204], 'Ballard': [3176], 'C.C.': [3177], 'Patel': [3178], 'Acta': [3180, 3210, 3255, 3383, 3471], 'Crystallogr.': [3181, 3185, 3211, 3215, 3256, 3260, 3384, 3388, 3462, 3472, 3476], 'Sect.': [3182, 3212, 3257, 3385, 3473], 'D': [3183, 3213, 3258, 3386, 3474], '58:': [3187], '1929-1936Crossref': [3188], '(41)': [3191], 'employed': [3195], 'means': [3197], 'graphical': [3200], 'interface': [3201], '(31Potterton': [3202], 'Turkenburg': [3206], 'Dodson': [3208, 3381], '59:': [3217], '1131-1137Crossref': [3218], '(1070)': [3221], 'convert': [3225], 'intensities': [3227, 4152], 'amplitudes': [3231], 'subsequent': [3234], 'calculations.': [3235], 'Structure': [3236], 'Determination': [3237], 'Refinement—The': [3239], 'solved': [3247], 'replacement': [3250], 'AMORE': [3252], '(32Navaza': [3253], '57:': [3262], '1367-1372Crossref': [3263], '(658)': [3266], 'truncated': [3274], '(28Ernst': [3279], 'search': [3301, 4296], 'model.': [3302, 3335], 'Automatic': [3303], 'model': [3304, 3344, 4198], 'building': [3305, 3345, 3401], 'ARP/wARP': [3307, 3403], '(35Perrakis': [3308, 3404], 'Morris': [3310, 3406], 'Lamzin': [3312, 3408], 'V.S.': [3313, 3409], '6:': [3318, 3414], '458-463Crossref': [3319, 3415], '(2564)': [3322, 3418], 'alternating': [3325], 'Refmac': [3327], 'refinement': [3328, 3337, 3363], 'performed': [3330, 3426, 3938, 4370], 'obtain': [3332], 'Further': [3336], 'iterative': [3340], 'cycles': [3341], 'interactive': [3343], 'XtalView': [3347], '(33McRee': [3348], 'D.E.': [3349], '125:': [3354], '156-165Crossref': [3355], '(2022)': [3358], 'restrained': [3362], 'minimization': [3365], 'maximum': [3368], 'likelihood': [3369], 'REFMAC': [3372], '(34Murshudov': [3373], 'G.N.': [3374], 'Vagin': [3375], 'Lebedev': [3377], 'Wilson': [3379], 'K.S.': [3380], 'E.J.': [3382], '55:': [3390, 3478], '247-255Crossref': [3391], '(1010)': [3394], 'coupled': [3397], 'automatic': [3399], 'solvent': [3400], 'Refinement': [3421], 'map': [3423], 'calculation': [3424, 3441], '95%': [3428], 'data;': [3431], '5%': [3432], 'randomly': [3434], 'chosen': [3435], 'reflections': [3436], 'Rfree.': [3443], 'Fig.': [3444, 3449, 3452, 4309], '1,': [3445], 'C,': [3448, 3741], '2,': [3450], '5A': [3453], 'prepared': [3455], 'MOLSCRIPT': [3457], '(36Kraulis': [3458], 'Appl.': [3461], '1991;': [3463], '24:': [3464], '946-950Crossref': [3465], 'BOBSCRIPT': [3468], '(37Esnouf': [3469], 'R.M.': [3470], '938-940Crossref': [3479], '(850)': [3482], 'RASTER3D': [3486], '(38Merrit': [3487], 'E.A.': [3488], 'Bacon': [3489], 'D.J.': [3490], '505-524Crossref': [3495], '(3875)': [3498], 'Scholar).Fig.': [3500], '2Layers.': [3501], 'Superposition': [3502], '0': [3508], '(A),': [3509], '-5': [3510], '(B),': [3511], '3': [3513, 4109], '(C)': [3514], '(red)': [3520, 3603, 3808], 'corresponding': [3523], '(blue).': [3530, 3818], 'Side': [3531, 3627], 'chains': [3532, 3628, 3658], 'participating': [3533], 'sticks.': [3540], 'C': [3542], 'chain': [3545], 'carbons': [3546], 'Thr1087': [3548], 'black,': [3552], 'oxygen': [3554], 'red.View': [3558], 'Large': [3559, 3828], 'Image': [3560, 3829], 'Figure': [3561, 3830], 'ViewerDownload': [3562, 3831], '(PPT)Fig.': [3563], '5Complexin': [3564], 'A,': [3573], 'ribbon': [3574], 'diagram': [3575], '(Cpx)': [3579], 'surface': [3583], 'Cpx': [3589, 3654, 3670, 3724, 3774], '(pink)': [3590], 'interacts': [3591], 'along': [3594], 'groove': [3596], '(blue)': [3600], 'Syx': [3602], 'simplification,': [3606], 'omitted.': [3611], 'structural': [3613], 'comparison,': [3614], 'overlaid': [3617], '(sky': [3620], 'blue)': [3621], 'sticks': [3632], 'color': [3636], 'code': [3637], 'ribbon,': [3640], 'except': [3641, 4473], 'tomosyn:': [3643], 'gray': [3644], '(carbons),': [3645], 'red': [3646], '(oxygens),': [3647], 'blue': [3649], '(nitrogens).': [3650], 'Salt': [3651], 'bridges': [3652], 'dotted': [3662], 'lines.': [3663], 'B,': [3664], '(arrowhead)': [3668], 'can': [3676], 'separated': [3678], 'non-denaturing': [3680], 'PAGE': [3681], 'constituents': [3684], '(26Pabst': [3685], 'Almost': [3715], 'no': [3716], 'band': [3718], 'observed': [3720, 3798, 4067], 'mixing': [3722, 3812], 'ran': [3736], 'double': [3739], 'band.': [3740], 'Red,': [3754], 'SyxH3,': [3755], 'either': [3757, 3976, 4238], 'preformed.': [3766], 'preformed': [3768], 'Green,': [3781], 'Cpx39OG.': [3782], 'excitation': [3784, 3985, 4093, 4162], '488': [3786, 3847, 3988], 'nm': [3787, 3989, 4003], 'pronounced': [3789], 'decrease': [3790], 'donor': [3792], 'fluorescence,': [3793], 'indicative': [3794], 'Cpx39OG': [3800, 3822, 4004, 4069], 'spectrum': [3820, 3982, 4012], 'alone': [3823], 'black.View': [3827], '(PPT)': [3832], 'Fluorescence': [3833], 'Measurements—Proteins': [3834], 'sulfhydryl-reactive': [3843], 'fluorophores': [3844], 'Green': [3846], 'iodoacetamide': [3848], 'Red': [3851], 'C5': [3852], 'bromoacetamide.': [3853], 'dialyzed': [3857, 3918], 'against': [3858, 3919], 'degassed': [3859], 'PBS': [3860, 3920, 3951, 4220], 'sodium': [3864], 'phosphate,': [3865], 'NaCl).': [3870], 'About': [3871], '10-fold': [3873], 'excess': [3874, 3901], 'probe': [3878], 'incubated': [3882, 3969], 'h.': [3885], 'stopped': [3889], 'addition': [3892, 4228, 4300], 'dithiothreitol.': [3896], 'h,': [3899], 'dye': [3902], 'gel': [3906], 'filtration': [3907], 'Sephadex': [3910], 'G-50': [3911], 'column.': [3912], 'Afterward,': [3913], 'buffer.': [3921, 3952, 4221], 'Experiments': [3922], 'carried': [3924, 4193, 4468], 'out': [3925, 4194, 4469], 'Fluoromax-2': [3928], 'spectrometer': [3929], 'equipped': [3930], 'autopolarizers': [3932], '(Jobin': [3933], 'Yvon).': [3934], 'measurements': [3936, 3959, 4191], 'quartz': [3943, 4202], 'cuvettes': [3944, 4203], '1-cm': [3946, 4205], 'path': [3947, 4206], '(Hellma)': [3949], '(FRET)': [3958], 'formed;': [3966], 'SNAP-25200TR': [3967], 'h': [3972], 'wavelength': [3986], 'recorded': [3991, 4014], 'formation.': [3994], 'To': [3995], '≈300': [4002], 'added,': [4006], 'min': [4010], 'again.': [4015], 'distance': [4022], 'Cα-atoms': [4025], 'SNAP-25200': [4027], 'Cpx39': [4029], '15.4': [4032], 'Å': [4033], '(39Chen': [4034], 'X.': [4035], 'Tomchick': [4036], 'D.R.': [4037], 'Kovrigin': [4038], 'Arac': [4040], 'Machius': [4042], '33:': [4050], '397-409Abstract': [4051], '(330)': [4059], 'No': [4062], 'change': [4063, 4080, 4277], 'unlabeled': [4077], 'Syb.': [4078], 'anisotropy': [4084, 4170], 'Red-labeled': [4087], '(Syb61TR)': [4089], 'measured': [4091], 'emission': [4095, 4159], 'wavelengths': [4096], '590': [4098], '610': [4100], 'nm,': [4101, 4110], 'respectively.': [4102, 4111], 'slit': [4104], 'widths': [4105], '2.5': [4107], 'G-factor': [4113], 'determined': [4115], 'G': [4118, 4180, 4186], '=': [4119, 4177], 'IHV/IHH,': [4120], 'I': [4122], 'intensity,': [4126], 'subscript': [4130, 4142], 'letter': [4131, 4143], 'indicates': [4132], 'direction': [4134, 4146], 'exciting': [4137], 'light,': [4138], 'emitted': [4148], 'Then': [4150], 'vertically': [4155, 4164], 'horizontally': [4157], 'polarized': [4158, 4165], 'light': [4160, 4166], 'measured.': [4168], '(r)': [4171], 'calculated': [4173], 'r': [4176], '(IVV': [4178], '-': [4179], 'IVH)/(IVV': [4182], '+': [4183], 'IVH).': [4188], 'Spectroscopy—The': [4190], 'Jasco': [4197], 'J-720': [4199], 'instrument': [4200], '(Hellma).': [4208], 'μm': [4217], 'started': [4225], 'non-interacting': [4233], 'mix': [4234], 'shorter': [4255], '30–89)': [4259], 'corresponded': [4263], 'Complex': [4271], 'followed': [4274], 'signal': [4281], '222': [4283], 'nm.': [4284], 'Analysis—New': [4286], 'searched': [4291], 'Blast': [4295], 'tool': [4297], '(www.ncbi.nlm.nih.gov/blast/).': [4298], 'sequences': [4303], 'alignments': [4307, 4358], '6': [4310], 'supplemental': [4313], 'data,': [4314], 'orthologs': [4318], 'species:': [4324], 'Gibberella': [4325], 'zeae,': [4326], 'gi': [4327, 4331, 4335], '42546760;': [4328], 'Candida': [4329], 'albicans,': [4330], '46433698;': [4332], 'Eremothecium': [4333], 'gossypii,': [4334], '45185876.': [4336], 'noted': [4339], 'new': [4343], 'Arabidopsis': [4347], 'thalania': [4348], 'already': [4350], 'listed': [4352], 'tomosyn-like': [4354], 'www.tc.umn.edu/~sande099/atsnare.htm.': [4356], 'Initial': [4357], 'ClustalW': [4372], '(www.ebi.ac.uk/clustalw)': [4373], '(40Thompson': [4374], 'J.D.': [4375], 'Higgins': [4376], 'D.G.': [4377], 'Gibson': [4378], 'T.J.': [4379], 'Nucleic': [4380, 4440], 'Acids': [4381, 4441], 'Res.': [4382, 4442], '1994;': [4383], '22:': [4384], '4673-4680Crossref': [4385], '(55767)': [4388], 'help': [4397], 'SMART': [4399], '(smart.embl.de/)': [4400], '(41Schultz': [4401], 'Milpetz': [4403], 'F.': [4404], 'Bork': [4405, 4438], 'Ponting': [4407, 4436], 'C.P.': [4408, 4437], '5857-5864Crossref': [4418], '(3020)': [4421], '42Letunic': [4424], 'I.': [4425], 'Copley': [4426], 'R.R.': [4427], 'Schmidt': [4428], 'Ciccarelli': [4430], 'F.D.': [4431], 'Doerks': [4432], 'Schultz': [4434], '32:': [4444], 'D142-D144Crossref': [4445], 'program': [4451], 'server': [4454], 'Biomolecular': [4457], 'Engineering': [4458], 'Research': [4459], 'Center': [4460], 'Boston': [4462], 'University': [4463], '(bmerc-www.bu.edu/wdrepeat/).': [4464], 'Other': [4465], 'Methods—SDS-PAGE': [4466], 'procedures,': [4472], 'samples': [4476], 'heated': [4479], '95': [4481], 'analysis': [4484], 'polyacr': [4487]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165068760', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-13T16:18:55.387478', 'created_date': '2016-06-24'}
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