Publication Information

{'id': 'https://openalex.org/W2164663878', 'doi': 'https://doi.org/10.1074/jbc.m700098200', 'title': 'Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1', 'display_name': 'Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1', 'publication_year': 2007, 'publication_date': '2007-01-24', 'ids': {'openalex': 'https://openalex.org/W2164663878', 'doi': 'https://doi.org/10.1074/jbc.m700098200', 'mag': '2164663878', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17244624'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m700098200', 'pdf_url': 'http://www.jbc.org/article/S0021925820638066/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 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[3, 162, 608, 623, 1089, 2205, 2238, 2583, 3171, 3739], 'insulin': [4, 29, 146, 155, 163, 188, 305, 314, 390, 444, 448, 613, 624, 647, 655, 1052, 1069, 1156, 1623, 1633, 1732, 1802, 1914, 1937, 1982, 2232, 2517, 2580, 2780, 2784, 3022, 3146, 3148, 3163, 3181, 3193, 3544, 3567, 3611, 3740], 'sensitizer,': [5, 164], 'and': [6, 35, 54, 87, 165, 194, 213, 246, 322, 332, 432, 443, 521, 643, 719, 756, 1043, 1166, 1180, 1189, 1274, 1308, 1312, 1315, 1317, 1329, 1336, 1351, 1384, 1522, 1537, 1567, 1588, 1737, 1745, 1751, 1781, 1821, 1841, 2034, 2200, 2210, 2214, 2380, 2503, 2522, 2539, 2563, 2590, 2707, 2858, 2992, 3164, 3180, 3210, 3379, 3404, 3411, 3565, 3610, 3626, 3637, 3690, 3725, 3751, 3758, 3765], 'yet': [7, 166], 'the': [8, 26, 68, 96, 111, 115, 121, 135, 139, 167, 185, 227, 255, 270, 274, 280, 294, 298, 517, 646, 707, 727, 734, 745, 877, 890, 1051, 1060, 1122, 1133, 1138, 1265, 1471, 1529, 1548, 1570, 1584, 1592, 1618, 1622, 1635, 1640, 1653, 1662, 1767, 1798, 1918, 1981, 1990, 2012, 2022, 2032, 2035, 2115, 2189, 2244, 2256, 2306, 2318, 2357, 2392, 2412, 2424, 2464, 2470, 2476, 2479, 2530, 2540, 2626, 2745, 2795, 2798, 2803, 2821, 2824, 2909, 2939, 2943, 3014, 3159, 3176, 3187, 3304, 3363, 3400, 3441, 3543, 3605, 3608, 3705, 3708, 3763], 'underlying': [9, 168, 1621], 'molecular': [10, 169, 616, 1150, 1619, 3732], 'mechanism(s)': [11, 170], 'remains': [12, 171, 626], 'largely': [13, 172, 627], 'unknown.': [14, 173, 628, 1058, 2485], 'We': [15, 174, 2177, 2349, 3744], 'found': [16, 175, 1077, 1973, 2178, 2350], 'that': [17, 132, 176, 291, 328, 605, 726, 883, 1066, 1078, 1130, 1910, 1974, 2011, 2179, 2228, 2351, 2513, 2532, 2577, 3016, 3228, 3532, 3557], 'treating': [18, 177], 'C2C12': [19, 127, 178, 286, 1072, 1356, 1630, 1995, 2175, 2403, 2719, 3136, 3219, 3570], 'myotubes': [20, 179, 1359, 1631, 1996], 'with': [21, 39, 180, 198, 1082, 1278, 1346, 1432, 1443, 1458, 1487, 1563, 1591, 1632, 1657, 1731, 1760, 1791, 1805, 1816, 1924, 1978, 1997, 2204, 2356, 2423, 2529, 2622, 2676, 2752, 2811, 3013, 3225, 3553, 3696], 'adiponectin': [22, 125, 153, 181, 284, 312, 386, 435, 512, 606, 620, 969, 1037, 1056, 1067, 1083, 1099, 1154, 1644, 1654, 1664, 1761, 1793, 1799, 1911, 1986, 1998, 2016, 2193, 2229, 2309, 2319, 2361, 2490, 2514, 2782, 3150, 3165, 3179, 3191, 3207, 3373, 3481, 3609, 3619, 3736], 'or': [23, 110, 182, 269, 1106, 1108, 1117, 1260, 1466, 1637, 1766, 1800, 2105, 2152, 2781, 2912, 2945, 3374], 'rapamycin': [24, 183, 1770, 1979, 2559, 2578, 3211, 3375], 'enhanced': [25, 77, 184, 236, 873, 2493, 2560, 3721], 'ability': [27, 186], 'of': [28, 57, 71, 90, 99, 103, 124, 134, 145, 187, 216, 230, 249, 258, 262, 283, 293, 304, 434, 439, 519, 645, 669, 704, 748, 869, 889, 1034, 1041, 1055, 1080, 1091, 1098, 1115, 1132, 1141, 1145, 1355, 1393, 1557, 1569, 1594, 1613, 1626, 1639, 1643, 1729, 1808, 1829, 1921, 1928, 1976, 1985, 1994, 2015, 2107, 2118, 2181, 2192, 2221, 2243, 2308, 2353, 2360, 2426, 2478, 2489, 2524, 2638, 2716, 2739, 2797, 2806, 2823, 2830, 2852, 2932, 2948, 2984, 2990, 3018, 3133, 3154, 3162, 3173, 3230, 3306, 3367, 3388, 3390, 3444, 3534, 3547, 3559, 3604, 3631, 3639, 3707, 3711, 3717, 3756], 'to': [30, 189, 436, 635, 640, 1039, 1358, 1470, 1650, 1652, 1734, 1834, 1934, 2363, 2463, 2595, 2636, 2828, 2988, 3139, 3145, 3361, 3398, 3407, 3621, 3629, 3685, 3720], 'stimulate': [31, 190], 'IRS-1': [32, 50, 191, 209, 749, 1190, 1736, 1750, 1780, 1838, 2019, 2222, 2371, 2564, 3197, 3234, 3368, 3391, 3403, 3431, 3487, 3562], 'tyrosine': [33, 192, 641, 1839, 2006, 2219, 2372, 3723], 'phosphorylation': [34, 44, 51, 80, 117, 193, 203, 210, 239, 276, 642, 747, 1086, 1124, 1576, 1739, 1753, 1783, 1810, 1840, 2007, 2196, 2213, 2220, 2312, 2373, 2382, 2565, 2700, 2725, 2747, 2777, 3142, 3199, 3217, 3229, 3307, 3366, 3387, 3488, 3499, 3564, 3716, 3724], 'Akt': [36, 79, 195, 238, 1261, 1738, 1752, 1782, 2195, 2381, 2562, 2699, 2724, 2776, 2889, 3141, 3726], 'phosphorylation,': [37, 196], 'concurrently': [38, 197], 'reduced': [40, 67, 199, 226, 1092, 2188, 3408], 'p70': [41, 140, 200, 299, 678], 'S6': [42, 141, 201, 300, 679], 'kinase': [43, 60, 202, 219, 938, 2542, 3497], 'at': [45, 52, 204, 211, 750, 1087, 1455, 1558, 1811, 2383, 2726, 2890, 3308, 3433, 3489], 'Thr389': [46, 205], 'well': [48, 207], 'Ser302': [53, 212, 3216, 3231], 'Ser636/639.': [55, 214], 'Overexpression': [56, 215, 2715, 2931], 'dominant-negative': [58, 64, 217, 223, 1112], 'AMP': [59, 218, 658, 937], '(AMPK),': [61, 220], 'but': [62, 74, 221, 233, 2183, 2325, 2366, 2475, 2585, 2941], 'not': [63, 75, 222, 234, 1795, 2184, 2323, 2326, 2713, 2861, 2937, 3536], 'p38': [65, 224, 1187, 2036], 'MAPK,': [66, 225, 691, 1188, 1314, 2186], 'insulin-sensitizing': [69, 97, 122, 228, 256, 281, 333, 1096, 2013, 2116, 2190, 2487, 2804], 'effect': [70, 98, 123, 229, 257, 282, 868, 1054, 1097, 1625, 1920, 1984, 2002, 2014, 2117, 2191, 2307, 2488, 2805, 2851, 3161, 3484, 3546], 'adiponectin.': [72, 100, 231, 259, 2807, 3548], 'Rapamycin,': [73, 232], 'adiponectin,': [76, 235, 1627, 2119, 2558], 'insulin-stimulated': [78, 237, 715, 1574, 1779, 1837, 2004, 2211, 2218, 2370, 2698, 2723, 3215, 3486], 'in': [81, 92, 108, 126, 157, 240, 251, 267, 285, 316, 516, 611, 675, 874, 1050, 1071, 1102, 1158, 1217, 1342, 1365, 1430, 1441, 1547, 1573, 1597, 1634, 1757, 1778, 1787, 2029, 2113, 2174, 2207, 2217, 2255, 2313, 2369, 2402, 2411, 2469, 2494, 2566, 2569, 2593, 2704, 2718, 2743, 2802, 3135, 3143, 3175, 3218, 3440, 3542, 3569, 3742], 'HeLa': [82, 93, 241, 252, 1437, 2314, 2354, 2413, 2495, 2567], 'cells,': [83, 242, 2031, 2315], 'which': [84, 152, 243, 311, 619, 713, 741, 965, 1136, 1153, 1646, 1813, 2202, 2250, 2316, 2396, 2420, 2526, 2575, 2744, 2818, 2887, 3190, 3703, 3735], 'lack': [85, 244], 'LKB1,': [86, 245, 1107, 2249, 2303, 2525], 'exogenous': [88, 247], 'expression': [89, 248, 1267, 1596], 'LKB1': [91, 250, 1259, 2327, 2499, 2538], 'cells': [94, 253, 875, 1081, 1103, 1339, 1357, 1364, 1427, 1438, 1730, 1758, 1977, 2355, 2404, 2496, 2568, 2720, 3137, 3571], 'rescued': [95, 254], 'Finally,': [101, 260], 'overexpression': [102, 261, 2180, 2738, 2983, 3132, 3153], 'wild-type': [104, 263, 1306, 1311, 1316, 1385, 2985, 3155], 'Rheb': [105, 264, 2853, 2859, 2986, 3156, 3174, 3712], '(Ras': [106, 265], 'homology-enriched': [107, 266], 'brain)': [109, 268], 'TSC2': [112, 271, 1120, 2592, 2620, 2742, 2809, 3687, 3694], 'mutant': [113, 272, 1119, 2741, 2934], 'lacking': [114, 273, 385, 876, 1104, 1121], 'AMPK': [116, 275, 1035, 1123, 1307, 2033, 2245, 2252, 2298, 2311, 2533, 2588, 2746, 3560, 3644, 3682], 'site': [118, 277, 1125, 2748, 2915, 3310, 3435, 3500], '(TSC2S1345A)': [119, 278], 'inhibited': [120, 279, 2703, 2775, 3214, 3371], 'cells.': [128, 158, 287, 317, 1159, 2176, 3743], 'These': [129, 288, 1127, 1426, 2225, 2789, 3168, 3221], 'results': [130, 289, 1128, 1553, 1908, 2226, 2511, 2677, 2790, 3222, 3301], 'indicate': [131, 290, 1129], 'activation': [133, 292, 644, 1033, 1131, 1828, 2257, 2299, 2989, 3017, 3558, 3638], 'LKB1/AMPK/TSC1/2': [136, 295], 'pathway': [137, 296, 702, 729, 893, 2801], 'alleviates': [138, 297], 'kinase-mediated': [142, 301], 'negative': [143, 302, 887, 1139], 'regulation': [144, 303, 1140], 'signaling,': [147, 306], 'providing': [148, 307], 'a': [149, 308, 325, 886, 960, 1048, 1111, 1118, 1149, 1658, 1806, 2215, 2364, 2399, 2570, 2740, 2815, 3493, 3539, 3554, 3602, 3700, 3731], 'mechanism': [150, 309, 617, 1151, 3188, 3733], 'by': [151, 310, 618, 633, 733, 744, 936, 968, 1036, 1152, 1362, 1535, 1539, 1579, 1611, 1916, 2234, 2302, 2536, 2779, 3189, 3200, 3372, 3392, 3734], 'increases': [154, 313, 1155], 'sensitivity': [156, 315, 449, 1157, 1915, 1938, 2581], '(Acrp30,': [319], 'AdipoQ,': [320], 'ApM1,': [321], 'GBP28)': [323], 'is': [324, 706, 730, 742, 871, 885, 934, 966, 2248, 2300, 2421, 2483, 2527, 2534, 2856, 3384, 3551, 3683], 'collagen-like': [326], 'adipokine': [327], 'has': [329, 1647, 1831, 1931, 3394, 3436], 'anti-atherogenic,': [330], 'antidiabetic,': [331], 'properties': [334], '(1Bouskila': [335], 'M.': [336, 485, 495, 773, 814, 847, 985, 989, 1680, 1684, 1851, 1944, 1948, 1950, 2055, 2059, 2130, 2160, 2276, 2329, 2657, 2685, 3039, 3080, 3113, 3243, 3452, 3462], 'Pajvani': [337, 398], 'U.B.': [338, 399], 'Scherer': [339, 371, 414], 'P.E.': [340, 372, 415], 'Int.': [341], 'J.': [342, 416, 453, 555, 586, 763, 843, 850, 907, 920, 973, 1415, 1668, 1847, 1854, 1883, 1896, 1958, 2043, 2132, 2163, 2443, 2683, 2921, 2965, 3029, 3109, 3116, 3239, 3246, 3275, 3288, 3319, 3336, 3343, 3506, 3513, 3587], 'Obes.': [343], '(Lond.).': [344], '2005;': [345, 361, 376, 832, 2901, 2923, 3098, 3322], '29': [346], '(Suppl.': [347], '1):': [348], 'S17-23Crossref': [349], 'PubMed': [350, 364, 379, 427, 505, 544, 566, 596, 779, 808, 835, 861, 926, 955, 1026, 1251, 1299, 1421, 1721, 1865, 1902, 1965, 2096, 2147, 2169, 2289, 2344, 2453, 2614, 2670, 2693, 2769, 2845, 2882, 2904, 2926, 2976, 3007, 3045, 3074, 3101, 3127, 3257, 3294, 3330, 3354, 3426, 3475, 3524, 3675], 'Scopus': [351, 365, 380, 428, 506, 545, 567, 597, 780, 809, 836, 862, 927, 956, 1027, 1252, 1300, 1422, 1722, 1866, 1903, 1966, 2097, 2148, 2170, 2290, 2345, 2454, 2553, 2615, 2671, 2694, 2770, 2846, 2883, 2905, 2927, 2977, 3008, 3046, 3075, 3102, 3128, 3258, 3295, 3331, 3355, 3427, 3476, 3525, 3592, 3676], '(143)': [352, 2884], 'Google': [353, 367, 382, 430, 508, 547, 569, 599, 782, 811, 838, 864, 929, 958, 1029, 1254, 1302, 1424, 1724, 1868, 1905, 1968, 2099, 2150, 2172, 2292, 2347, 2456, 2555, 2617, 2673, 2696, 2772, 2848, 2885, 2907, 2929, 2979, 3010, 3048, 3077, 3104, 3130, 3260, 3297, 3333, 3357, 3429, 3478, 3527, 3594, 3678], 'Scholar,': [354, 368, 548, 570, 783, 812, 839, 1869, 3049, 3078, 3105, 3261, 3334], '2Kadowaki': [355], 'T.': [356, 358, 451, 465, 499, 529, 574, 759, 761, 793, 901, 943, 971, 979, 983, 993, 1015, 1017, 1021, 1287, 1666, 1674, 1678, 1688, 1710, 1712, 1716, 1877, 2041, 2049, 2053, 2063, 2085, 2087, 2091, 2162, 2274, 2433, 2435, 2437, 2441, 2602, 2655, 2681, 2757, 2837, 2999, 3025, 3027, 3059, 3269], 'Yamauchi': [357], 'Endocr.': [359], 'Rev.': [360, 2547], '26:': [362, 3424], '439-451Crossref': [363], '(2102)': [366], '3Nawrocki': [369], 'A.R.': [370, 393], 'Drug': [373], 'Discov.': [374], 'Today.': [375], '10:': [377], '1219-1230Crossref': [378], '(128)': [381], 'Scholar).': [383, 509, 600, 865, 930, 1030, 1255, 1303, 1425, 1725, 1969, 2100, 2293, 2348, 2457, 2556, 2618, 2674, 2849, 2930, 2980, 3011, 3358, 3430, 3479, 3528, 3595, 3679], 'Mice': [384], 'have': [387, 724, 1064], 'severe': [388], 'hepatic': [389], 'resistance': [391, 445], '(4Nawrocki': [392], 'Rajala': [394], 'M.W.': [395], 'Tomas': [396], 'E.': [397, 550, 2869], 'Saha': [400], 'A.K.': [401], 'Trumbauer': [402], 'M.E.': [403, 822, 3088], 'Pang': [404], 'Z.': [405], 'Chen': [406, 410, 3753], 'A.S.': [407], 'Ruderman': [408], 'N.B.': [409], 'H.': [411, 455, 481, 787, 905, 999, 1398, 1402, 1694, 1881, 2069, 2124, 2439, 3053, 3273, 3470], 'Rossetti': [412], 'L.': [413, 845, 1230, 1849, 2962, 3111, 3241, 3654], 'Biol.': [417, 556, 851, 922, 1247, 1855, 1898, 2165, 2280, 2661, 2966, 3117, 3247, 3290, 3320, 3344, 3422, 3514, 3671], 'Chem.': [418, 557, 852, 1856, 2967, 3118, 3248, 3321, 3345, 3515], '2006;': [419, 1248, 2445, 2879, 3423, 3589, 3672], '281:': [420], '2654-2660Abstract': [421], 'Full': [422, 424, 561, 563, 591, 593, 856, 858, 950, 952, 1294, 1296, 1860, 1862, 2284, 2286, 2448, 2450, 2609, 2611, 2665, 2667, 2764, 2766, 2971, 2973, 3122, 3124, 3252, 3254, 3325, 3327, 3349, 3351, 3519, 3521], 'Text': [423, 425, 562, 564, 592, 594, 857, 859, 951, 953, 1295, 1297, 1861, 1863, 2285, 2287, 2449, 2451, 2610, 2612, 2666, 2668, 2765, 2767, 2972, 2974, 3123, 3125, 3253, 3255, 3326, 3328, 3350, 3352, 3520, 3522], 'PDF': [426, 565, 595, 860, 954, 1298, 1864, 2288, 2452, 2613, 2669, 2768, 2975, 3126, 3256, 3329, 3353, 3523], '(528)': [429], 'Scholar),': [431, 959, 1906, 2697, 2773, 2886, 2908, 3131, 3298], 'administration': [433], 'animal': [437], 'models': [438], 'type': [440, 522, 3445], '2': [441, 523, 2733, 3446], 'diabetes': [442, 524, 3447], 'significantly': [446, 1935, 2187, 3157], 'enhances': [447, 3192], '(5Yamauchi': [450], 'Kamon': [452, 972, 1667, 2042], 'Waki': [454, 998, 1693, 2068], 'Terauchi': [456, 1004, 1699, 2074], 'Y.': [457, 463, 473, 487, 535, 539, 578, 975, 1003, 1005, 1670, 1698, 1700, 2045, 2073, 2075, 2835, 2997, 3466], 'Kubota': [458], 'N.': [459, 469, 1408], 'Hara': [460, 986, 1681, 2056], 'K.': [461, 467, 483, 489, 527, 767, 941, 987, 991, 1009, 1013, 1285, 1406, 1682, 1686, 1704, 1708, 2057, 2061, 2079, 2083, 2264, 2600, 2645, 2755, 2833, 2867, 2995, 3033, 3450], 'Mori': [462], 'Ide': [464], 'Murakami': [466, 990, 1685, 2060], 'Tsuboyama-Kasaoka': [468], 'Ezaki': [470], 'O.': [471, 475], 'Akanuma': [472], 'Gavrilova': [474], 'Vinson': [476], 'C.': [477], 'Reitman': [478], 'M.L.': [479], 'Kagechika': [480], 'Shudo': [482], 'Yoda': [484], 'Nakano': [486], 'Tobe': [488, 1008, 1703, 2078], 'Nagai': [490, 1018, 1713, 2088], 'R.': [491, 1019, 1714, 2089, 2156, 3338], 'Kimura': [492], 'S.': [493, 580, 803, 903, 911, 981, 995, 997, 1011, 1676, 1690, 1692, 1706, 1879, 1887, 1952, 2051, 2065, 2067, 2081, 2142, 2158, 2339, 2877, 3069, 3271, 3279, 3456], 'Tomita': [494], 'Froguel': [496, 1006, 1701, 2076], 'P.': [497, 552, 1007, 1228, 1702, 2077, 3318, 3454, 3652], 'Kadowaki': [498, 1020, 1715, 2090], 'Nat.': [500, 1245, 3669], 'Med.': [501], '2001;': [502, 541, 805, 3071], '7:': [503], '941-946Crossref': [504], '(4075)': [507], 'In': [510, 1059, 1074, 1970, 2736, 2981, 3359, 3616], 'humans,': [511], 'levels': [513, 1930], 'are': [514, 1554, 1602, 2111, 3223], 'low': [515], 'plasma': [518], 'obese': [520], 'subjects': [525, 3448], '(6Hotta': [526], 'Funahashi': [528, 573], 'Bodkin': [530], 'N.L.': [531], 'Ortmeyer': [532], 'H.K.': [533], 'Arita': [534], 'Hansen': [536, 844, 1848, 3110, 3240], 'B.C.': [537], 'Matsuzawa': [538, 577], 'Diabetes.': [540, 3471], '50:': [542], '1126-1133Crossref': [543], '(958)': [546], '7Hu': [549], 'Liang': [551], 'Spiegelman': [553], 'B.M.': [554], '1996;': [558], '271:': [559], '10697-10703Abstract': [560], '(1890)': [568], '8Lindsay': [571], 'R.S.': [572], 'Hanson': [575], 'R.L.': [576], 'Tanaka': [579], 'Tataranni': [581], 'P.A.': [582], 'Knowler': [583], 'W.C.': [584], 'Krakoff': [585], 'Lancet.': [587], '2002;': [588, 2144, 2690, 3516], '360:': [589], '57-58Abstract': [590], '(973)': [598], 'The': [601, 615, 866, 1095, 1199, 2458, 2486, 2850, 3680], 'combined': [602], 'data': [603, 3169], 'suggest': [604, 1909, 2227, 2512, 3170], 'plays': [607, 1047, 3538], 'important': [609], 'role': [610, 1049, 3541], 'sensitizing': [612, 1053, 1624, 1983, 3545], 'action.': [614], 'acts': [621], 'sensitizer': [625, 3741], 'Insulin': [629], 'initiates': [630], 'its': [631, 636, 3412, 3622], 'action': [632, 3023, 3568], 'binding': [634], 'membrane': [637, 717, 3623], 'receptor,': [638], 'leading': [639, 2635, 2827, 3406, 3628, 3719], 'receptor': [648, 2320], '(IR).': [649], '2The': [650], 'abbreviations': [651], 'used': [652], 'are:': [653], 'IR,': [654], 'receptor;': [656], 'AMPK,': [657, 1116, 1186], 'kinase;': [659, 680, 694], 'DN,': [660], 'dominant': [661], 'negative;': [662], 'IRS,': [663, 3718], 'IR': [664, 705, 2005], 'substrate;': [665], 'mTOR,': [666], 'mammalian': [667, 1266], 'target': [668], 'rapamycin;': [670], 'Rheb,': [671, 1110, 1146, 2634, 2825], 'Ras': [672], 'homology': [673], 'enriched': [674], 'brain;': [676], 'S6K,': [677, 3535], 'TORC,': [681], 'TOR': [682, 735, 2627], 'complex;': [683, 687], 'TSC,': [684], 'tuberous': [685, 878], 'sclerosis': [686, 879], 'PI3K,': [688, 3405], 'phosphatidylinositol': [689, 708], '3-kinase;': [690], 'mitogen-activated': [692], 'protein': [693, 963, 1575, 1595, 2409], 'DMEM,': [695, 1369], "Dulbecco's": [696], 'modified': [697], "Eagle's": [698], 'medium.': [699], 'A': [700, 1775, 2199, 2502, 3378], 'major': [701, 2027, 3494, 3540], 'downstream': [703, 1842, 3414, 3640], '3-kinase': [709], '(PI3K)': [710], 'signaling': [711, 739, 892, 1070, 1803, 1843, 2038, 2109, 2233, 2240, 2518, 2800, 3182, 3612], 'pathway,': [712, 740, 1135], 'mediates': [714], 'GLUT4': [716], 'translocation': [718], 'glucose': [720], 'uptake.': [721], 'Recent': [722], 'studies': [723], 'shown': [725, 1065, 1649, 1833, 1933, 2468, 3397], 'PI3K': [728, 3409], 'negatively': [731, 1835, 2624, 3020, 3232], 'regulated': [732], 'complex': [736, 880, 2628], '1': [737, 1512, 1523, 2629], '(TORC1)-induced': [738], 'mediated': [743, 2301, 3413], 'S6K-dependent': [746], 'several': [751], 'sites': [752], 'including': [753], 'Ser302,': [754, 3362], 'Ser307,': [755], 'Ser636/639': [757, 3365, 3389], '(9Haruta': [758, 3024], 'Uno': [760, 3026], 'Kawahara': [762, 3028], 'Takano': [764, 3030], 'A.': [765, 804, 899, 977, 1672, 1875, 2047, 2143, 2260, 2331, 2340, 2431, 2641, 2878, 3031, 3070, 3267, 3312, 3314, 3417], 'Egawa': [766, 3032], 'Sharma': [768, 3034], 'P.M.': [769, 3035], 'Olefsky': [770, 3036], 'J.M.': [771, 2126, 3037], 'Kobayashi': [772, 3038], 'Mol.': [774, 3040, 3420], 'Endocrinol.': [775, 3041], '2000;': [776, 2166, 3042], '14:': [777, 3043], '783-794Crossref': [778, 3044], '(322)': [781, 3047], '10Ozes': [784, 3050], 'O.N.': [785, 3051], 'Akca': [786, 3052], 'Mayo': [788, 3054], 'L.D.': [789, 3055], 'Gustin': [790, 3056], 'J.A.': [791, 3057], 'Maehama': [792, 3058], 'Dixon': [794, 3060], 'J.E.': [795, 3061], 'Donner': [796, 3062], 'D.B.': [797, 3063], 'Proc.': [798, 2137, 2334, 2872, 3064], 'Natl.': [799, 2138, 2335, 2873, 3065], 'Acad.': [800, 2139, 2336, 2874, 3066], 'Sci.': [801, 2140, 2337, 2875, 3067], 'U.': [802, 2141, 2272, 2338, 2653, 2876, 3068], '98:': [806, 3072], '4640-4645Crossref': [807, 3073], '(326)': [810, 3076], '11Ueno': [813, 3079], 'Carvalheira': [815, 3081], 'J.B.': [816, 3082], 'Tambascia': [817, 3083], 'R.C.': [818, 3084], 'Bezerra': [819, 3085], 'R.M.': [820, 3086], 'Amaral': [821, 3087], 'Carneiro': [823, 3089], 'E.M.': [824, 3090], 'Folli': [825, 3091], 'F.': [826, 1242, 1410, 1942, 1946, 2919, 2964, 3092, 3458, 3666], 'Franchini': [827, 3093], 'K.G.': [828, 3094], 'Saad': [829, 3095], 'M.J.': [830, 2134, 3096], 'Diabetologia.': [831, 3097], '48:': [833, 3099], '506-518Crossref': [834, 3100], '(156)': [837, 3103], '12Werner': [840, 3106], 'E.D.': [841, 1845, 3107, 3237, 3504], 'Lee': [842, 1846, 3108, 3238, 3339, 3507], 'Yuan': [846, 1850, 3112, 3242], 'Shoelson': [848, 1852, 3114, 3244, 3509], 'S.E.': [849, 1606, 1853, 3115, 3245, 3510], '2004;': [853, 923, 1857, 1899, 1962, 3119, 3249, 3291, 3346], '279:': [854, 1858, 3120, 3250, 3347], '35298-35305Abstract': [855, 1859, 3121, 3251], '(191)': [863, 1867, 3129, 3259], 'inhibitory': [867, 1919], 'S6K': [870, 1042, 1085, 1093, 1768, 1809, 1817, 1830, 2212, 2236, 2993, 3019], 'greatly': [872, 2492, 2702, 3370], '(TSC1/2),': [881], 'suggesting': [882, 2010], 'TSC1/2': [884, 932, 1105], 'regulator': [888], 'mTOR/S6K': [891, 1142, 2639, 3393], '(13Harrington': [894], 'L.S.': [895, 1871, 2429, 3263], 'Findlay': [896, 1872, 3264], 'G.M.': [897, 1873, 3265], 'Gray': [898, 1874, 3266], 'Tolkacheva': [900, 1876, 3268], 'Wigfield': [902, 1878, 3270], 'Rebholz': [904, 1880, 3272], 'Barnett': [906, 1882, 3274], 'Leslie': [908, 1884, 3276], 'N.R.': [909, 1885, 3277], 'Cheng': [910, 1886, 3278], 'Shepherd': [912, 1888, 3280], 'P.R.': [913, 1889, 1954, 3281], 'Gout': [914, 1890, 3282], 'I.': [915, 1891, 3283], 'Downes': [916, 1892, 3284], 'C.P.': [917, 1893, 3285], 'Lamb': [918, 1894, 3286], 'R.F.': [919, 1895, 3287], 'Cell': [921, 1194, 1246, 1333, 1897, 2164, 3289, 3670], '166:': [924, 1900, 3292], '213-223Crossref': [925, 1901, 3293], '(927)': [928, 1904, 3296], 'Interestingly,': [931, 1797, 2391, 3480], 'activity': [933, 1818, 2822, 2947, 3410, 3706], 'stimulated': [935], '(AMPK)': [939], '(14Inoki': [940, 1284, 2599, 2754], 'Zhu': [942, 1286, 2601, 2756], 'Guan': [944, 1288, 2603, 2758, 2838, 2870, 3000], 'K.L.': [945, 1289, 2604, 2759, 2839, 2871, 3001], 'Cell.': [946, 1290, 2605, 2760, 3421], '2003;': [947, 1023, 1291, 1418, 1718, 2093, 2281, 2606, 2662, 2761, 2842, 2968, 3004, 3472], '115:': [948, 1292, 2607, 2762], '577-590Abstract': [949, 1293, 2608, 2763], '(3013)': [957, 1301, 2616, 2771], 'heterotrimeric': [961], 'serine/threonine': [962], 'kinase,': [964], 'activated': [967, 2535, 3681], '(15Yamauchi': [970, 1665, 2040], 'Ito': [974, 1669, 2044], 'Tsuchida': [976, 1671, 2046], 'Yokomizo': [978, 1673, 2048], 'Kita': [980, 1675, 2050], 'Sugiyama': [982, 1677, 2052], 'Miyagishi': [984, 1679, 2054], 'Tsunoda': [988, 1683, 2058], 'Ohteki': [992, 1687, 2062], 'Uchida': [994, 1689, 2064], 'Takekawa': [996, 1691, 2066], 'Tsuno': [1000, 1695, 2070], 'N.H.': [1001, 1696, 2071], 'Shibata': [1002, 1697, 2072], 'Koyasu': [1010, 1705, 2080], 'Taira': [1012, 1707, 2082], 'Kitamura': [1014, 1709, 2084], 'Shimizu': [1016, 1711, 2086], 'Nature.': [1022, 1717, 1961, 2092], '423:': [1024, 1719, 2094], '762-769Crossref': [1025, 1720, 2095], '(2647)': [1028, 1723, 2098], 'However,': [1031], 'whether': [1032, 1044, 2103, 2296], 'leads': [1038, 2987], 'inhibition': [1040, 1046, 1144, 2637, 2829, 3533], 'this': [1045, 1925, 3309, 3434, 3617], 'remain': [1057], 'present': [1061], 'study,': [1062], 'we': [1063, 1076, 1628, 1972, 2120, 2304, 3195, 3600], 'sensitizes': [1068], 'myotubes.': [1073, 3220], 'addition,': [1075, 1971], 'treatment': [1079, 1728, 1993, 2352], 'inhibits': [1084, 2820, 2936, 3158, 3704], 'Thr389,': [1088, 1812], 'indicator': [1090], 'activity.': [1094], 'was': [1100, 1161, 1203, 1213, 1360, 1577, 1589, 1609, 1754, 1784, 2491, 2701, 2750, 3369], 'suppressed': [1101], 'overexpressing': [1109], '(DN)': [1113], 'form': [1114, 1642, 2359], '(TSC2S1345A).': [1126], 'LKB1/AMPK/TSC': [1134], 'relieves': [1137], 'via': [1143, 2519, 2582], 'may': [1147, 1912, 2230, 2515], 'provide': [1148, 2791], 'Reagents—Rapamycin': [1160], 'purchased': [1162, 1170, 1192, 1204], 'from': [1163, 1171, 1193, 1205, 1323, 1825, 2678], 'Sigma.': [1164], 'Anti-IRS-1': [1165], 'anti-IR': [1167], 'antibodies': [1168, 1182, 1544], 'were': [1169, 1191, 1262, 1281, 1320, 1340, 1390, 1428, 1439, 1453, 1462, 1476, 1485, 1532], 'Santa': [1172], 'Cruz': [1173], 'Biotechnology,': [1174], 'Inc.': [1175], '(Santa': [1176], 'Cruz,': [1177], 'CA).': [1178], 'Antibodies': [1179], 'phosphospecific': [1181, 3204], 'for': [1183, 1479, 2794, 3754, 3762], 'Akt,': [1184], 'p70S6K,': [1185], 'Signaling': [1195], 'Technology': [1196], '(Beverly,': [1197], 'MA).': [1198], 'phosphotyrosine': [1200], 'antibody': [1201], '(4G10)': [1202], 'Upstate': [1206], 'Biotechnology': [1207], '(Lake': [1208], 'Placid,': [1209], 'NY).': [1210], 'His-tagged': [1211], 'gAdiponectin': [1212], 'produced': [1214], 'described': [1216, 1282], 'our': [1218], 'recent': [1219, 3555], 'work': [1220], '(16Mao': [1221, 3645], 'X.': [1222, 3646], 'Kikani': [1223, 3647], 'C.K.': [1224, 3648], 'Riojas': [1225, 3649], 'R.A.': [1226, 3650], 'Langlais': [1227, 3651], 'Wang': [1229, 3653], 'Ramos': [1231, 3655], 'F.J.': [1232, 3656], 'Fang': [1233, 3657], 'Q.': [1234, 2865, 3658], 'Christ-Roberts': [1235, 3659], 'C.Y.': [1236, 3660], 'Hong': [1237, 3661], 'J.Y.': [1238, 3662], 'Kim': [1239, 2868, 3663], 'R.Y.': [1240, 3664], 'Liu': [1241, 2918, 3665], 'Dong': [1243, 3667], 'L.Q.': [1244, 2917, 3668], '8:': [1249, 3673], '516-523Crossref': [1250, 3674], '(544)': [1253, 3677], 'Plasmids—cDNAs': [1256], 'encoding': [1257, 1272, 1305], 'full-length': [1258, 1663, 1792], 'cloned': [1263], 'into': [1264], 'vector': [1268], 'pcDNA3.1/Myc-His(+)': [1269], '(Invitrogen).': [1270, 1474], 'Plasmids': [1271, 1304], 'Wt-TSC2': [1273, 2717], 'Mut-TSC2': [1275], '(S1345A)': [1276], 'tagged': [1277], 'hemagglutinin': [1279], 'constructs': [1280], 'previously': [1283], 'DN-AMPK': [1309, 2122], '(K45R),': [1310], 'DN-p38': [1313, 2153, 2185], 'DN-Rheb': [1318, 2933, 3134], '(D60K)': [1319, 2935], 'generous': [1321, 1391], 'gifts': [1322, 1392, 3755], 'Drs.': [1324, 3746], 'Michael': [1325, 3747], 'Quon,': [1326, 3748], 'Jiahuai': [1327, 3749], 'Han,': [1328, 3750], 'Jie': [1330, 3752], 'Chen,': [1331], 'respectively.': [1332], 'Lines,': [1334], 'Transfection,': [1335], 'Western': [1337, 1540, 1551, 1581, 3201], 'Blot—C2C12': [1338], 'maintained': [1341, 1429, 1440], 'DMEM': [1343, 1431, 1442], '(ATCC)': [1344], 'supplemented': [1345], '10%': [1347, 1433, 1444], 'fetal': [1348, 1434, 1445], 'bovine': [1349], 'serum': [1350], '1%': [1352, 1448, 1498], 'penicillin/streptomycin.': [1353, 1449], 'Differentiation': [1354], 'done': [1361], 'growing': [1363], 'low-serum': [1366], 'medium': [1367], '(98%': [1368], '2%': [1370], '(v/v)': [1371], 'horse': [1372], 'serum,': [1373, 1447], '4.0': [1374], 'mm': [1375, 1378, 1491, 1496, 1502, 1505, 1509, 1513, 1524], 'glutamine,': [1376], '25': [1377], 'Hepes,': [1379, 1492], 'pH': [1380, 1493], '7.4).': [1381], 'TSC1–/–,': [1382], 'TSC2–/–,': [1383], 'control': [1386], 'mouse': [1387, 1788, 2709], 'embryonic': [1388, 2710], 'fibroblasts': [1389, 2711], 'Dr.': [1394, 3759], 'David': [1395, 3760], 'Kwiatkowski': [1396, 1413, 3761], '(17Zhang': [1397], 'Cicchetti': [1399], 'G.': [1400, 1960, 2687], 'Onda': [1401], 'Koon': [1403], 'H.B.': [1404], 'Asrican': [1405], 'Bajraszewski': [1407], 'Vazquez': [1409], 'Carpenter': [1411], 'C.L.': [1412, 2954], 'D.J.': [1414], 'Clin.': [1416], 'Investig.': [1417], '112:': [1419], '1223-1233Crossref': [1420], '(443)': [1423], 'calf': [1435, 1446], 'serum.': [1436], 'All': [1450], 'cell': [1451, 1530, 2414, 3767], 'lines': [1452], 'grown': [1454], '37': [1456], '°C': [1457], '5%': [1459], 'CO2.': [1460], 'Transfections': [1461], 'performed': [1463, 1578], 'using': [1464, 1542, 1583, 3203], 'Lipofectamine': [1465, 1467], '2000': [1468], 'according': [1469], 'manufacturer’s': [1472], 'protocol': [1473], 'Cells': [1475, 1484], 'normally': [1477], 'serum-starved': [1478], '4–6': [1480], 'h': [1481], 'before': [1482], 'treatment.': [1483], 'lysed': [1486], 'lysis': [1488], 'buffer': [1489], '(50': [1490], '7.6,': [1494], '150': [1495], 'NaCl,': [1497], 'Triton': [1499], 'X-100,': [1500], '10': [1501, 1516, 1519], 'NaF,': [1503], '20': [1504, 1508], 'sodium': [1506, 1514], 'pyrophosphate,': [1507], 'β-glycerol': [1510], 'phosphate,': [1511], 'orthovanadate,': [1515], 'μg/ml': [1517, 1520], 'leupeptin,': [1518], 'aprotinin,': [1521], 'phenylmethanesulfonyl': [1525], 'fluoride).': [1526], 'After': [1527], 'centrifugation,': [1528], 'lysates': [1531, 2415], 'denatured,': [1533], 'separated': [1534], 'SDS-PAGE,': [1536], 'analyzed': [1538], 'blot': [1541, 1552, 3202], 'specific': [1543], 'indicated': [1546], 'figure': [1549], 'legends.': [1550], 'typically': [1555], 'representative': [1556], 'least': [1559], 'three': [1560], 'independent': [1561, 2523], 'experiments': [1562], 'similar': [1564, 1776], 'results.': [1565], 'Quantification': [1566], 'Statistics—Quantification': [1568], 'relative': [1571], 'increase': [1572, 1777, 1913, 2206, 2368], 'analyzing': [1580], 'blots': [1582], 'Scion': [1585], 'Image': [1586], 'software': [1587], 'normalized': [1590], 'amount': [1593], 'each': [1598], 'experiment.': [1599], 'Values': [1600], 'presented': [1601], 'mean': [1603], 'values': [1604], '±': [1605], 'Statistical': [1607], 'significance': [1608], 'determined': [1610], 'analysis': [1612], 'variance': [1614], '(ANOVA).': [1615], 'To': [1616, 2101, 2294, 3184], 'elucidate': [1617, 3186], 'mechanisms': [1620], 'treated': [1629], 'absence': [1636], 'presence': [1638], 'globular': [1641, 2358], '(gAd),': [1645], 'been': [1648, 1832, 1932, 3396, 3438], 'bind': [1651], 'receptor-1': [1655], '(AdipoR1)': [1656], 'higher': [1659], 'affinity': [1660], 'than': [1661, 2021], 'As': [1726], 'expected,': [1727], 'led': [1733, 2362, 3138], 'increased': [1735, 1756, 2579, 2722, 3140], '(Fig.': [1740, 1762, 1771, 1819, 1987, 2008, 2197, 2223, 2374, 2385, 2405, 2416, 2473, 2500, 2573, 2728, 2785, 3166, 3208, 3212, 3376, 3491, 3614], '1,': [1741], 'A,': [1742], 'lane': [1743, 1747, 2376, 2387, 2505, 2732], '2,': [1744, 2198], 'B,': [1746, 1822, 2504, 3380], '3).': [1748], 'Insulin-stimulated': [1749], 'markedly': [1755, 2774], 'pretreated': [1759, 1790], '1A,': [1763], 'lanes': [1764, 1773, 2787], '3–5)': [1765], 'inhibitor': [1769], '1B,': [1772], '4–6).': [1774], 'also': [1785, 1814, 2942, 3437], 'observed': [1786, 3439], 'hepatocytes': [1789], '(data': [1794, 2322, 2712], 'shown).': [1796, 2714], 'rapamycin-enhanced': [1801], 'correlated': [1804, 1815], 'reduction': [1807], '1A': [1820], 'fifth': [1823], 'panel': [1824, 2472], 'top).': [1826], 'Because': [1827], 'regulate': [1836], '(12Werner': [1844, 3236], '13Harrington': [1870, 3262], 'these': [1907, 2108, 2510, 3598], 'alleviating': [1917], 'S6K.': [1922], 'Consistent': [1923, 2675, 3012], 'idea,': [1926], 'suppression': [1927], 'S6K1': [1929], 'improve': [1936], '(18Um': [1939], 'S.H.': [1940], 'Frigerio': [1941], 'Watanabe': [1943], 'Picard': [1945], 'Joaquin': [1947], 'Sticker': [1949], 'Fumagalli': [1951], 'Allegrini': [1953], 'Kozma': [1955], 'S.C.': [1956], 'Auwerx': [1957], 'Thomas': [1959, 2686], '431:': [1963], '200-205Crossref': [1964], '(1367)': [1967], 'pretreatment': [1975], 'blunted': [1980], '1C).': [1988], 'On': [1989], 'other': [1991], 'hand,': [1992], 'had': [1999, 3482], 'no': [2000], 'significant': [2001], 'on': [2003, 2194, 2253, 2310, 2854, 3303, 3485, 3597, 3688], '1D),': [2009], 'directly': [2017], 'targets': [2018], 'rather': [2020], 'IR.': [2023], 'activates': [2025, 2591], 'two': [2026, 2408], 'pathways': [2028, 2039, 2110, 2520, 3613], 'muscle': [2030, 3443], 'MAPK': [2037, 2154], 'determine': [2102, 2295], 'any': [2104], 'both': [2106, 2208, 2537, 2705], 'involved': [2112], 'mediating': [2114], 'overexpressed': [2121], '(19Zong': [2123], 'Ren': [2125], 'Young': [2127], 'L.H.': [2128], 'Pypaert': [2129], 'Mu': [2131], 'Birnbaum': [2133], 'Shulman': [2135], 'G.I.': [2136], '99:': [2145], '15983-15987Crossref': [2146], '(832)': [2149], 'Scholar)': [2151, 2173], '(20Fujii': [2155], 'Yamashita': [2157], 'Hibi': [2159], 'Hirano': [2161], '150:': [2167], '1335-1348Crossref': [2168], '(59)': [2171], 'DN-AMPK,': [2182], 'B),': [2201], 'coincided': [2203], 'basal': [2209, 2940], 'decrease': [2216], '2C).': [2224], 'sensitize': [2231, 2516], 'inhibiting': [2235], 'through': [2237], 'AMPK-dependent': [2239], 'pathway.': [2241], 'One': [2242], 'upstream': [2246, 2631], 'kinases': [2247, 3641], 'phosphorylates': [2251, 2589, 2888], 'Thr172': [2254], 'loop': [2258], '(21Woods': [2259, 2640], 'Johnstone': [2261, 2642], 'S.R.': [2262, 2643], 'Dickerson': [2263, 2644], 'Leiper': [2265, 2646], 'F.C.': [2266, 2647], 'Fryer': [2267, 2648], 'L.G.': [2268, 2649], 'Neumann': [2269, 2650], 'D.': [2270, 2278, 2651, 2659], 'Schlattner': [2271, 2652], 'Wallimann': [2273, 2654], 'Carlson': [2275, 2656], 'Carling': [2277, 2658], 'Curr.': [2279, 2660], '13:': [2282, 2663], '2004-2008Abstract': [2283, 2664], '(1340)': [2291, 2672], 'adiponectin-stimulated': [2297], 'examined': [2305, 3196], 'express': [2317], 'AdipoR1': [2321, 3625], 'shown)': [2324], '(22Tiainen': [2328], 'Ylikorkala': [2330], 'Makela': [2332], 'T.P.': [2333], '1999;': [2341], '96:': [2342], '9248-9251Crossref': [2343], '(263)': [2346], 'small': [2365], 'notable': [2367], '3A,': [2375], '4': [2377, 2388], 'versus': [2378, 2389, 2507, 2734], '2)': [2379], 'Thr308': [2384, 2727], '3B,': [2386, 2417], '2).': [2390], 'same': [2393], 'anti-Akt': [2394], 'antibody,': [2395], 'detected': [2397], 'only': [2398, 2938], 'single': [2400], 'band': [2401, 2461, 2466, 2482], '1),': [2406], 'recognized': [2407], 'bands': [2410], 'lower': [2418], 'panel),': [2419], 'consistent': [2422, 2528, 3224, 3552], 'findings': [2425, 2531, 3227], 'others': [2427, 2679], '(23Faried': [2428], 'Faried': [2430], 'Kanuma': [2432], 'Nakazato': [2434], 'Tamura': [2436], 'Kuwano': [2438], 'Minegishi': [2440], 'Eur.': [2442], 'Cancer.': [2444], '42:': [2446], '934-947Abstract': [2447], '(64)': [2455], 'slower': [2459], 'migrating': [2460, 2481], 'corresponds': [2462], 'phospho-Akt': [2465], 'top': [2471, 2730], '3B),': [2474], 'identity': [2477], 'faster': [2480], 'currently': [2484], 'transiently': [2497], 'expressing': [2498], '3,': [2501], '6': [2506], '4).': [2508], 'Together,': [2509], 'dependent': [2521], 'Ca2+-dependent': [2541], 'CaMKKβ': [2543], '(24Hardie': [2544], 'D.G.': [2545, 3581], 'Annu.': [2546], 'Pharmacol.': [2548], 'Toxicol.': [2549], '2007;': [2550], '47:': [2551], '2.1-2.26Crossref': [2552], '(356)': [2554], 'Unlike': [2557], 'insulin-induced': [2561, 3364], 'dose-dependent': [2571], 'manner': [2572], '3D),': [2574], 'suggested': [2576], 'mTOR/S6K-dependent': [2584], 'LKB1-independent': [2586], 'mechanism.': [2587], 'response': [2594, 3144], 'cellular': [2596], 'energy': [2597], 'starvation': [2598], 'Activated': [2619, 2808, 3693], 'together': [2621, 2810, 3695], 'TSC1': [2623, 2812, 3697], 'regulates': [2625, 3021, 3233], '(TORC1)': [2630], 'activator,': [2632], 'termed': [2633], '(25Radimerski': [2680], 'Montagne': [2682], 'Hemmings-Mieszczak': [2684], 'Genes': [2688, 2840, 3002], 'Dev.': [2689, 2841, 3003], '16:': [2691], '2627-2632Crossref': [2692], '(170)': [2695], 'TSC1–/–': [2706, 3764], 'TSC2–/–': [2708, 3766], 'moderately': [2721], '4A,': [2729], 'panel,': [2731], '5).': [2735, 3167], 'contrast,': [2737, 2982], 'Ser1345': [2749, 3689], 'replaced': [2751], 'alanine': [2753], 'induced': [2778], 'plus': [2783, 3149], '4,': [2786], '7–9).': [2788], 'strong': [2792], 'evidence': [2793], 'involvement': [2796, 3172], 'AMPK/TSC': [2799], 'serves': [2813, 3698], 'GTPase-activating': [2816, 3701], 'protein,': [2817, 3702], 'subsequently': [2819], 'ultimately': [2826], 'TORC1': [2831, 2855], '(26Inoki': [2832, 2994], 'Li': [2834, 2996], 'Xu': [2836, 2998], '17:': [2843, 3005], '1829-1834Crossref': [2844, 3006], '(1424)': [2847, 3009], 'specific,': [2857], 'does': [2860], 'activate': [2862, 3691], 'TORC2': [2863], '(27Yang': [2864], 'Inoki': [2866], '103:': [2880], '6811-6816Crossref': [2881], 'Ser473': [2891], '(28Sarbassov': [2892], 'D.D.': [2893], 'Guertin': [2894], 'D.A.': [2895], 'Ali': [2896], 'S.M.': [2897], 'Sabatini': [2898], 'D.M.': [2899], 'Science.': [2900], '307:': [2902], '1098-1101Crossref': [2903], '(5257)': [2906], 'so-called': [2910], 'PDK2': [2911], 'hydrophobic': [2913], 'motif': [2914], '(29Dong': [2916], 'Am.': [2920, 3586], 'Physiol.': [2922, 3588], '289:': [2924], 'E187-E196Crossref': [2925], '(112)': [2928], 'nutrient-': [2944], 'serum-induced': [2946], 'p70S6K': [2949], '(30Tabancay': [2950], 'Jr.,': [2951], 'A.P.': [2952], 'Gau': [2953], 'Machado': [2955], 'I.M.': [2956], 'Uhlmann': [2957], 'E.J.': [2958], 'Gutmann': [2959], 'D.H.': [2960], 'Guo': [2961], 'Tamanoi': [2963], '278:': [2969], '39921-39930Abstract': [2970], '(93)': [2978], 'mTOR': [2991], 'observation': [3015], 'and/or': [3147], 'treatment,': [3151], 'whereas': [3152], 'stimulatory': [3160], 'cross-talk': [3177, 3606], 'between': [3178, 3402, 3607], 'pathways.': [3183], 'further': [3185], 'sensitivity,': [3194], 'serine': [3198, 3563, 3715], 'antibodies.': [3205], 'Both': [3206], '6A)': [3209], '6B)': [3213], 'previous': [3226], 'function': [3235], 'although': [3299], 'controversial': [3300], 'exist': [3302], 'roles': [3305], '(31Danielsson': [3311], 'Ost': [3313], 'Nystrom': [3315], 'F.H.': [3316], 'Stralfors': [3317], '280:': [3323], '34389-34392Abstract': [3324], '(65)': [3332], '32Giraud': [3335], 'Leshan': [3337], 'Y.H.': [3340, 3508], 'White': [3341, 3511], 'M.F.': [3342, 3512], '3447-3454Abstract': [3348], '(82)': [3356], 'addition': [3360], '6,': [3377], 'respectively).': [3381], 'This': [3382, 3529, 3549, 3728], 'finding': [3383, 3530, 3556], 'interesting': [3385], 'because': [3386], 'recently': [3395], 'interrupt': [3399], 'interaction': [3401], 'events': [3415], '(33Tzatsos': [3416], 'Kandror': [3418], 'K.V.': [3419], '63-76Crossref': [3425], '(334)': [3428], 'hyperphosphorylated': [3432], 'skeletal': [3442], '(34Bouzakri': [3449], 'Roques': [3451], 'Gual': [3453], 'Espinosa': [3455], 'Guebre-Egziabher': [3457], 'Riou': [3459], 'J.P.': [3460], 'Laville': [3461], 'March': [3463], 'Le': [3464], '-Brustel': [3465], 'Tanti': [3467], 'J.F.': [3468], 'Vidal': [3469], '52:': [3473], '1319-1325Crossref': [3474], '(240)': [3477], 'little': [3483], 'Ser307': [3490], '6A),': [3492], 'c-Jun': [3495], 'N-terminal': [3496], '(JNK)-mediated': [3498], '(35Aguirre': [3501], 'V.': [3502], 'Werner': [3503], 'Giraud': [3505], '277:': [3517], '1531-1537Abstract': [3518], '(769)': [3526], 'suggests': [3531], 'JNK,': [3537], 'result': [3550], 'reduces': [3561, 3713], 'potentiates': [3566], '(36Ju': [3572], 'J.S.': [3573, 3585], 'Gitcho': [3574], 'M.A.': [3575], 'Casmaer': [3576], 'C.A.': [3577], 'Patil': [3578], 'P.B.': [3579], 'Han': [3580], 'Spencer': [3582], 'S.A.': [3583], 'Fisher': [3584], '292:': [3590], 'C564-C572Crossref': [3591], '(37)': [3593], 'Based': [3596], 'findings,': [3599], 'describe': [3601], 'model': [3603, 3729], '7).': [3615], 'model,': [3618], 'binds': [3620], 'receptors,': [3624], 'AdipoR2,': [3627], 'recruitment': [3630], 'adaptor': [3632], 'proteins': [3633], 'such': [3634, 3642], 'APPL1': [3636], 'able': [3684], 'phosphorylate': [3686], 'it.': [3692], 'Rheb.': [3709], 'Inhibition': [3710], 'mTOR/S6K-mediated': [3714], 'IRS': [3722], 'phosphorylation.': [3727], 'provides': [3730], 'thank': [3745], 'plasmids': [3757], 'lines.': [3768]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2164663878', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2024-12-24T13:24:49.840584', 'created_date': '2016-06-24'}