Title: STUDIES ON THE GROWTH IN TISSUE CULTURE OF THE CORPUS LUTEUM AND OF THE ISOLATED OVARIAN FOLLICLE OF THE RAT
Abstract:ABSTRACT The growth of corpus luteum tissue fragments and single ovarian follicles from rat and the hormonal influence on such growth was studied in tissue culture. Both types of tissue gave good grow...ABSTRACT The growth of corpus luteum tissue fragments and single ovarian follicles from rat and the hormonal influence on such growth was studied in tissue culture. Both types of tissue gave good growth. Oestrone inhibited the growth of the theca cells around the follicles during dioestrus, but stimulated the growth of the corpus luteum fragments , provided, however, that they had been dissected from rats in dioestrus. Progesterone appeared to inhibit the growth of theca cells from follicles removed from animals in oestrus. F. S. H. inhibited the growth of theca cells from follicles excised from animals in dioestrus, but stimulated the growth of these cells from animals in oestrus. L. T. H. stimulated growth of corpus luteum fragments that had been isolated from animals in oestrus, but had no effect when the specimens had been removed from animals in dioestrus. The findings suggest that steroid hormones and gonadotrophins may directly inhibit or stimulate the growth of certain ovarian cells and that oestrogens are necessary for the gonadotrophic hormones to exert a stimulating effect locally on the ovary.Read More
Publication Year: 1961
Publication Date: 1961-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 11
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