Publication Information

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'https://openalex.org/W2007546762', 'https://openalex.org/W2011349880', 'https://openalex.org/W2041451676', 'https://openalex.org/W2044154722', 'https://openalex.org/W2049229440', 'https://openalex.org/W2051567146', 'https://openalex.org/W2056983875', 'https://openalex.org/W2068226571', 'https://openalex.org/W2071864606', 'https://openalex.org/W2072303535', 'https://openalex.org/W2083422904', 'https://openalex.org/W2094262605', 'https://openalex.org/W2109177164', 'https://openalex.org/W2112631592', 'https://openalex.org/W2113275211', 'https://openalex.org/W2114360920', 'https://openalex.org/W2137720344', 'https://openalex.org/W2151502323', 'https://openalex.org/W2152732984', 'https://openalex.org/W2164952534', 'https://openalex.org/W4245958271'], 'related_works': ['https://openalex.org/W77561063', 'https://openalex.org/W4253770744', 'https://openalex.org/W4249112201', 'https://openalex.org/W4248721660', 'https://openalex.org/W4241983134', 'https://openalex.org/W4205487352', 'https://openalex.org/W2973192241', 'https://openalex.org/W2894385453', 'https://openalex.org/W2358034211', 'https://openalex.org/W2083668272'], 'abstract_inverted_index': {'The': [0, 70, 121, 191, 242, 475, 636, 1591, 1610, 1735, 1768, 1788, 1801, 1878, 1970, 1993, 2014, 2069, 2102, 2128, 2156, 2175, 2196, 2259, 2295, 2319, 2411, 2476, 2595, 2875, 2999, 3161, 3592, 3923], 'aging': [1, 122, 472], 'suppressor': [2, 123, 473], 'gene': [3, 124, 244, 274, 340, 468, 696, 723, 3925], 'Klotho': [4, 37, 51, 61, 82, 86, 108, 125, 158, 172, 182, 203, 207, 229, 243, 273, 339, 467, 479, 623, 630, 643, 1247, 1264, 1382, 1451, 1458, 1504, 1551, 1634, 1890, 2034, 2441, 2451, 2539, 2557, 2574, 2591, 2663, 2670, 2684, 2725, 2744, 2771, 2776, 2859, 2928, 2939, 2950, 2963, 2978, 2984, 3018, 3036, 3068, 3087, 3101, 3107, 3139, 3166, 3254, 3270, 3306, 3424, 3475, 3479, 3506, 3522, 3547, 3599, 3624, 3678, 3773, 3924, 3939], 'encodes': [5, 126, 245], 'a': [6, 13, 43, 111, 127, 134, 164, 232, 246, 252, 268, 276, 558, 617, 695, 1253, 1272, 1305, 1395, 1507, 1553, 2028, 2042, 2191, 2200, 2210, 2405, 2931, 3298, 3325, 3426, 3498, 3542, 3617, 3778, 3799], 'single-pass': [7, 128, 248], 'transmembrane': [8, 129, 249, 640, 1371, 1448, 1547, 2536, 2927], 'protein.': [9, 130, 690], 'Klotho-deficient': [10, 131, 1155], 'mice': [11, 132, 352, 963, 1156, 1162, 3175, 3186, 3795, 3847], 'exhibit': [12, 133], 'variety': [14, 135], 'of': [15, 19, 91, 96, 105, 116, 136, 140, 212, 217, 226, 237, 337, 478, 564, 628, 638, 642, 682, 736, 1192, 1373, 1380, 1442, 1450, 1457, 1549, 1569, 1617, 1660, 1737, 1930, 1958, 1990, 2003, 2017, 2032, 2052, 2082, 2109, 2118, 2136, 2143, 2177, 2218, 2243, 2273, 2344, 2367, 2389, 2407, 2479, 2485, 2538, 2549, 2573, 2608, 2683, 2696, 2709, 2724, 2743, 2779, 2788, 2808, 2815, 2834, 2871, 2938, 2949, 2983, 2992, 3002, 3035, 3080, 3117, 3131, 3258, 3269, 3302, 3305, 3316, 3413, 3422, 3474, 3505, 3515, 3521, 3528, 3598, 3677, 3787, 3810, 3933, 3946], 'aging-like': [16, 137], 'phenotypes,': [17, 138, 1168], 'many': [18, 139, 1166, 3188], 'which': [20, 141, 568, 3055, 3438, 3575], 'are': [21, 142, 2461, 3416, 3839, 3940], 'similar': [22, 143, 2876], 'to': [23, 65, 74, 93, 144, 186, 195, 214, 348, 571, 647, 726, 1007, 1114, 1122, 1243, 1266, 1310, 1319, 1337, 1400, 1491, 1657, 1799, 1804, 1892, 1964, 2001, 2099, 2232, 2251, 2330, 2416, 2455, 2559, 2575, 2616, 2620, 2673, 2685, 2698, 2737, 2747, 2781, 2790, 2831, 2864, 2908, 2930, 2952, 3005, 3037, 3096, 3098, 3109, 3145, 3167, 3263, 3300, 3327, 3517, 3532, 3585, 3604, 3762, 3768, 3942, 3955], 'those': [24, 145, 2909, 3842], 'observed': [25, 146, 2579, 2891, 3022, 3043, 3180, 3843], 'in': [26, 42, 54, 102, 147, 163, 175, 223, 263, 271, 351, 485, 698, 720, 732, 924, 930, 934, 965, 1118, 1126, 1130, 1182, 1389, 1414, 1431, 1619, 1676, 1681, 1793, 1895, 1904, 1973, 2049, 2160, 2204, 2324, 2445, 2496, 2502, 2570, 2604, 2704, 2721, 2838, 2852, 2897, 2910, 2919, 2956, 3009, 3023, 3044, 3181, 3192, 3199, 3552, 3620, 3627, 3784, 3797, 3844, 3930], 'fibroblast': [27, 148, 659, 663], 'growth': [28, 149, 651, 660, 664, 1173], 'factor-23': [29, 150, 652], '(FGF23)-deficient': [30, 151], 'mice.': [31, 152, 3183], 'To': [32, 153, 2436, 2679, 2794, 3030], 'test': [33, 154, 2437, 2680, 2795, 3031], 'the': [34, 89, 155, 210, 264, 272, 338, 342, 466, 486, 626, 629, 639, 721, 1183, 1244, 1285, 1311, 1320, 1333, 1370, 1377, 1390, 1401, 1432, 1446, 1454, 1479, 1485, 1492, 1502, 1545, 1565, 1574, 1586, 1597, 1631, 1682, 1905, 1945, 1959, 1974, 1997, 2012, 2080, 2161, 2178, 2226, 2278, 2313, 2345, 2394, 2438, 2464, 2497, 2534, 2550, 2571, 2581, 2605, 2609, 2694, 2705, 2722, 2730, 2740, 2766, 2786, 2861, 2869, 2903, 2925, 2935, 2946, 2957, 2961, 2976, 2980, 3010, 3024, 3033, 3066, 3085, 3094, 3115, 3178, 3256, 3267, 3308, 3314, 3411, 3419, 3471, 3483, 3502, 3518, 3526, 3529, 3553, 3569, 3595, 3610, 3621, 3628, 3674, 3785, 3931, 3947], 'possibility': [35, 156, 2731, 3611], 'that': [36, 60, 157, 181, 465, 561, 1246, 1263, 1394, 1499, 1984, 2002, 2440, 2531, 2732, 2760, 2858, 2945, 2974, 3138, 3163, 3253, 3410, 3470, 3497, 3541, 3564, 3594, 3612, 3794, 3801], 'and': [38, 100, 159, 221, 259, 291, 345, 483, 929, 973, 1050, 1121, 1159, 1179, 1248, 1269, 1314, 1326, 1376, 1406, 1425, 1473, 1642, 1654, 1668, 1679, 1689, 1783, 1797, 1869, 1911, 1962, 2035, 2087, 2172, 2267, 2308, 2328, 2351, 2361, 2481, 2506, 2545, 2599, 2614, 2667, 2692, 2707, 2718, 2812, 2820, 2836, 2850, 2894, 2979, 3019, 3052, 3059, 3069, 3133, 3136, 3157, 3206, 3273, 3293, 3428, 3492, 3559, 3673, 3681, 3757, 3808, 3952], 'FGF23': [39, 75, 92, 160, 196, 213, 722, 737, 920, 966, 1005, 1160, 1249, 1335, 1653, 1934, 1947, 1971, 1989, 1998, 2008, 2215, 2280, 2370, 2399, 2408, 2701, 2711, 2733, 2750, 2761, 2780, 2789, 2811, 2829, 2847, 2865, 2996, 3003, 3039, 3099, 3164, 3285, 3318, 3535, 3586, 3605, 3761, 3788], 'may': [40, 161, 1250, 2442, 2671, 2687, 3113, 3171, 3251, 3296, 3507, 3549, 3614, 3751, 3927], 'function': [41, 162, 637, 1251, 2985, 3001, 3615, 3776], 'common': [44, 165, 1167, 1254], 'signal': [45, 166, 1255], 'transduction': [46, 167, 1256], 'pathway(s),': [47, 168], 'we': [48, 58, 169, 179, 1261, 2448, 2798, 2890, 2972, 3049, 3076], 'investigated': [49, 170, 2449], 'whether': [50, 171, 2450, 2681, 3032, 3771], 'is': [52, 173, 260, 481, 1506, 2483, 2602, 3004, 3425, 3539, 3625, 3679], 'involved': [53, 174, 2444, 3551], 'FGF': [55, 67, 97, 117, 176, 188, 218, 238, 1009, 1116, 1276, 1661, 2346, 2382, 2446, 2792, 2816, 2993, 3135, 3147, 3153, 3169, 3275, 3329, 3934, 3949], 'signaling.': [56, 177, 2793, 3789, 3935], 'Here': [57, 178], 'show': [59, 180, 968, 1262, 2762, 3187], 'protein': [62, 183, 250, 480, 644, 1560, 1802, 2110, 2137, 3548, 3800], 'directly': [63, 184, 620, 2453, 2735], 'binds': [64, 73, 185, 194, 1006, 1265, 3108], 'multiple': [66, 187, 1008, 1267, 1566, 2473, 2674, 3110, 3259, 3264], 'receptors': [68, 189, 1010], '(FGFRs).': [69, 190], 'Klotho-FGFR': [71, 192, 2767, 3530], 'complex': [72, 193, 2768, 3531, 3948], 'with': [76, 197, 251, 700, 960, 1420, 1435, 1464, 1478, 1552, 1630, 1652, 1743, 1750, 1754, 1774, 1786, 1813, 1871, 1882, 1902, 1914, 1944, 1955, 1983, 1996, 2106, 2115, 2133, 2140, 2181, 2199, 2225, 2265, 2270, 2277, 2285, 2301, 2312, 2364, 2393, 2540, 2555, 2590, 2662, 2676, 2715, 2765, 2770, 2805, 2914, 2924, 2934, 3063, 3072, 3088, 3128, 3280, 3482, 3510, 3525, 3760, 3841, 3962], 'higher': [77, 198], 'affinity': [78, 199, 1045, 2466, 2619, 3485, 3555], 'than': [79, 200, 2592, 2664, 2769, 3120, 3587], 'FGFR': [80, 201, 1480, 2227, 2474, 2542, 2562, 2773, 3020], 'or': [81, 202, 1057, 1453, 1557, 1625, 1635, 1739, 1758, 1865, 1927, 2146, 2221, 2246, 2337, 2375, 2380, 2431, 2488, 2772, 2802, 2873, 3125, 3322], 'alone.': [83, 204, 2774], 'In': [84, 205, 1258, 2841, 2888, 3074, 3313], 'addition,': [85, 206, 2889, 3075], 'significantly': [87, 208], 'enhanced': [88, 209, 2860], 'ability': [90, 211, 2572, 2695, 2787, 3095, 3144, 3527], 'induce': [94, 215, 2832], 'phosphorylation': [95, 216, 1982, 2814, 2833, 2896], 'receptor': [98, 219, 1044, 2458, 2817], 'substrate': [99, 220], 'ERK': [101, 222, 1981, 2895], 'various': [103, 224, 1956, 2365, 2541, 2806, 3129], 'types': [104, 225], 'cells.': [106, 227, 1621, 2840, 2912, 3013], 'Thus,': [107, 228, 2669], 'functions': [109, 230, 469, 1270], 'as': [110, 231, 470, 557, 694, 1055, 1271, 1664, 1691, 1908, 2027, 2164, 2190, 2209, 2404, 2463, 2622, 2960, 2986, 3047, 3324, 3430, 3489, 3616, 3777], 'cofactor': [112, 233, 1273, 3326], 'essential': [113, 234], 'for': [114, 235, 1275, 1332, 1467, 1640, 1646, 1687, 1746, 1765, 2011, 2073, 2090, 2122, 2150, 2167, 2194, 2213, 2237, 2256, 2292, 2384, 2397, 2989, 3418], 'activation': [115, 236, 1278, 2991], 'signaling': [118, 239, 618, 1117, 1277, 1662, 2994, 3148, 3170, 3330, 3950], 'by': [119, 240, 622, 728, 1279, 1614, 1940, 1979, 1986, 2995, 3433], 'FGF23.': [120, 241, 1280, 3073, 3089, 3121, 3312, 3423, 3560], '130-kDa': [247], 'short': [253], 'cytoplasmic': [254], 'domain': [255, 477, 1379, 1456, 2478, 2500, 2613, 2742, 2937, 2948, 2982, 3597, 3676], '(10': [256, 2845], 'amino': [257], 'acids)': [258], 'expressed': [261, 2203, 2533, 2954, 3103, 3568, 3626], 'predominantly': [262, 3567], 'kidney.': [265, 3622], 'Mice': [266], 'carrying': [267], 'loss-of-function': [269], 'mutation': [270], 'develop': [275, 1165, 3176], 'syndrome': [277], 'resembling': [278], 'human': [279, 1988, 2007, 2369, 2810], 'aging,': [280], 'including': [281, 625, 1169, 3195], 'shortened': [282, 1170], 'life': [283, 343, 1171], 'span,': [284, 1172], 'skin': [285, 3202], 'atrophy,': [286, 288, 1177, 3203], 'muscle': [287, 1176], 'osteoporosis,': [289], 'arteriosclerosis,': [290, 3196], 'pulmonary': [292, 3207], 'emphysema': [293, 3208], '(1Kuro-o': [294, 3209, 3632], 'M.': [295, 309, 356, 370, 384, 395, 407, 415, 433, 491, 505, 519, 578, 592, 606, 842, 872, 937, 978, 1029, 1076, 1091, 1133, 1197, 1697, 1711, 1725, 1846, 2639, 3210, 3224, 3332, 3371, 3386, 3633, 3647, 3686, 3700, 3714, 3853, 3859, 3883], 'Matsumura': [296, 3211, 3634], 'Y.': [297, 307, 325, 376, 409, 439, 445, 511, 536, 544, 598, 804, 838, 844, 850, 980, 984, 1199, 1203, 1228, 1350, 1354, 1522, 1530, 1717, 1820, 1852, 3212, 3222, 3240, 3449, 3457, 3635, 3645, 3663, 3706, 3731, 3739, 3822, 3824], 'Aizawa': [298, 3213, 3636], 'H.': [299, 301, 315, 354, 368, 372, 405, 435, 489, 503, 507, 576, 590, 594, 810, 824, 982, 1201, 1695, 1709, 1713, 1836, 3214, 3216, 3230, 3637, 3639, 3653, 3684, 3698, 3702], 'Kawaguchi': [300, 371, 506, 593, 1712, 3215, 3638, 3701], 'Suga': [302, 3217, 3640], 'T.': [303, 305, 311, 319, 449, 542, 798, 802, 806, 848, 852, 856, 888, 976, 986, 992, 1089, 1195, 1205, 1211, 1224, 1226, 1342, 1344, 1348, 1356, 1360, 1528, 1844, 3218, 3220, 3226, 3234, 3384, 3455, 3641, 3643, 3649, 3657, 3737, 3816, 3881], 'Utsugi': [304, 3219, 3642], 'Ohyama': [306, 3221, 3644], 'Kurabayashi': [308, 3223, 3646], 'Kaname': [310, 3225, 3648], 'Kume': [312, 3227, 3650], 'E.': [313, 1822, 3228, 3651], 'Iwasaki': [314, 3229, 3652], 'Iida': [316, 1833, 3231, 3654], 'A.': [317, 362, 403, 497, 530, 532, 584, 745, 818, 880, 886, 1093, 1516, 1518, 1703, 1826, 1828, 1834, 1840, 1842, 3232, 3388, 3443, 3445, 3655, 3692, 3725, 3727, 3818, 3885], 'Shiraki-Iida': [318, 3233, 3656], 'Nishikawa': [320, 3235, 3658], 'S.': [321, 766, 858, 884, 939, 988, 1135, 1207, 1358, 1824, 3236, 3334, 3659, 3814], 'Nagai': [322, 3237, 3660], 'R.': [323, 768, 796, 840, 943, 1017, 1064, 1139, 3238, 3338, 3359, 3661], 'Nabeshima': [324, 543, 1227, 1529, 1851, 3239, 3456, 3662, 3738, 3821, 3823], 'Nature.': [326, 3241, 3664], '1997;': [327, 3242, 3665], '390:': [328, 3243, 3666], '45-51Crossref': [329, 3244, 3667], 'PubMed': [330, 389, 427, 457, 524, 550, 611, 713, 760, 788, 832, 866, 902, 915, 954, 999, 1036, 1083, 1109, 1150, 1218, 1233, 1365, 1536, 1730, 1860, 2522, 2651, 3245, 3349, 3378, 3404, 3463, 3668, 3719, 3745, 3831, 3875, 3918], 'Scopus': [331, 390, 428, 458, 525, 551, 612, 714, 761, 789, 833, 867, 903, 916, 955, 1000, 1037, 1084, 1110, 1151, 1219, 1234, 1366, 1537, 1731, 1861, 2523, 2652, 3246, 3350, 3379, 3405, 3464, 3669, 3720, 3746, 3832, 3876, 3919], '(2811)': [332, 3247, 3670], 'Google': [333, 392, 430, 460, 527, 553, 614, 716, 763, 791, 835, 869, 905, 918, 957, 1002, 1039, 1086, 1112, 1153, 1221, 1236, 1368, 1539, 1733, 1863, 2525, 2654, 3248, 3352, 3381, 3407, 3466, 3671, 3722, 3748, 3834, 3878, 3921], 'Scholar).': [334, 461, 615, 919, 958, 1003, 1154, 1237, 1540, 1734, 2526, 2655, 3249, 3467, 3835, 3922], 'Conversely,': [335], 'overexpression': [336], 'extends': [341], 'span': [344], 'increases': [346], 'resistance': [347, 725], 'oxidative': [349], 'stress': [350], '(2Kurosu': [353, 488, 575, 1694, 3683], 'Yamamoto': [355, 440, 490, 577, 805, 1696, 3685], 'Clark': [357, 396, 492, 579, 1698, 3687], 'J.D.': [358, 397, 493, 580, 1699, 3688], 'Pastor': [359, 398, 494, 581, 1700, 3689], 'J.V.': [360, 399, 495, 582, 1701, 3690], 'Nandi': [361, 402, 496, 583, 1702, 3691], 'Gurnani': [363, 400, 498, 585, 1704, 3693], 'P.': [364, 401, 499, 586, 892, 895, 1705, 3694], 'McGuinness': [365, 500, 587, 1706, 3695], 'O.P.': [366, 501, 588, 1707, 3696], 'Chikuda': [367, 502, 589, 1708, 3697], 'Yamaguchi': [369, 504, 591, 1710, 3699], 'Shimomura': [373, 508, 595, 1714, 3703], 'I.': [374, 447, 509, 596, 1346, 1715, 2512, 3704], 'Takayama': [375, 510, 597, 1716, 3705], 'Herz': [377, 512, 599, 1718, 3707], 'J.': [378, 416, 443, 513, 600, 777, 822, 827, 859, 896, 910, 993, 1098, 1212, 1719, 2514, 2627, 2640, 3393, 3708, 3820, 3825, 3864], 'Kahn': [379, 514, 601, 1720, 3709], 'C.R.': [380, 515, 602, 1721, 3710], 'Rosenblatt': [381, 412, 516, 603, 1722, 3711], 'K.P.': [382, 413, 517, 604, 1723, 3712], 'Kuro-o': [383, 414, 518, 605, 1724, 1845, 3713], 'Science.': [385, 520, 607, 1726, 3715], '2005;': [386, 419, 521, 608, 946, 1033, 1080, 1142, 1727, 2519, 3341, 3375, 3716, 3828, 3910], '309:': [387, 522, 609, 1728, 3717], '1829-1833Crossref': [388, 523, 610, 1729, 3718], '(1397)': [391, 526, 613, 1732, 3721], 'Scholar,': [393, 431, 528, 764, 792, 836, 870, 906, 1087, 1222, 3353, 3382, 3723, 3879], '3Yamamoto': [394], 'Kurosu': [404], 'Miyoshi': [406], 'Ogawa': [408], 'Castrillon': [410], 'D.H.': [411], 'Biol.': [417, 778, 1099, 2641, 3394, 3865], 'Chem.': [418, 779, 1100, 2642, 3395, 3866], '280:': [420], '38029-38034Abstract': [421], 'Full': [422, 424, 755, 757, 783, 785, 949, 951, 1104, 1106, 1145, 1147, 2646, 2648, 3344, 3346, 3399, 3401, 3870, 3872, 3913, 3915], 'Text': [423, 425, 756, 758, 784, 786, 950, 952, 1105, 1107, 1146, 1148, 2647, 2649, 3345, 3347, 3400, 3402, 3871, 3873, 3914, 3916], 'PDF': [426, 759, 787, 953, 1108, 1149, 2650, 3348, 3403, 3874, 3917], '(528)': [429], '4Ikushima': [432], 'Rakugi': [434], 'Ishikawa': [436], 'K.': [437, 441, 538, 814, 846, 854, 990, 1095, 1209, 1352, 1524, 1830, 1832, 1850, 3390, 3451, 3733], 'Maekawa': [438], 'Ohta': [442], 'Chihara': [444], 'Kida': [446], 'Ogihara': [448], 'Biochem.': [450, 1853], 'Biophys.': [451, 1854], 'Res.': [452, 1855], 'Commun.': [453, 1856], '2006;': [454], '339:': [455], '827-832Crossref': [456], '(188)': [459], 'These': [462, 1238, 2757, 3090], 'observations': [463, 1239, 2758], 'suggest': [464], 'an': [471, 1580, 3781], 'gene.': [474], 'extracellular': [476, 685, 1378, 1455, 2477, 2741, 2936, 2947, 2981, 3596, 3675, 3772], 'shed': [482, 3680], 'secreted': [484, 3682], 'blood': [487], '5Imura': [529, 3724], 'Iwano': [531, 1517, 1839, 3444, 3726], 'Tohyama': [533, 1519, 3446, 3728], 'O.': [534, 812, 1520, 3447, 3729], 'Tsuji': [535, 1521, 3448, 3730], 'Nozaki': [537, 1523, 3450, 3732], 'Hashimoto': [539, 1525, 3452, 3734], 'N.': [540, 825, 878, 1097, 1526, 1838, 1848, 3392, 3453, 3735], 'Fujimori': [541, 1225, 1527, 1843, 3454, 3736, 3815], 'FEBS': [545, 1531, 3458, 3740], 'Lett.': [546, 1532, 3459, 3741], '2004;': [547, 996, 1215, 1533, 3460, 3742], '565:': [548, 1534, 3461, 3743], '143-147Crossref': [549, 1535, 3462, 3744], '(457)': [552, 1538, 3465, 3747], 'Scholar),': [554, 717, 1040, 1369, 3408, 3749], 'potentially': [555], 'functioning': [556], 'humoral': [559], 'factor': [560, 665, 3619, 3783], 'signals': [562, 1879], 'suppression': [563], 'intracellular': [565], 'insulin/IGF1': [566], 'signaling,': [567, 2447], 'partly': [569, 3577], 'contributes': [570], 'its': [572, 3281, 3953], 'anti-aging': [573], 'properties': [574], 'However,': [616, 2567, 2739, 3184], 'pathway(s)': [619], 'activated': [621, 2848], 'protein,': [624], 'identity': [627], 'receptor,': [631], 'has': [632, 1042, 3608], 'not': [633, 2886, 3141, 3190], 'been': [634], 'determined.': [635, 649], 'form': [641, 1372, 1449, 1548, 2537], 'also': [645, 2402, 2943, 3562], 'remains': [646, 3767], 'be': [648, 2443, 2553, 3042, 3550, 3769], 'Fibroblast': [650], '(FGF23)': [653], '2The': [654], 'abbreviations': [655], 'used': [656, 2010, 2026, 2189, 2208, 2403], 'are:': [657], 'FGF,': [658], 'factor;': [661], 'FGFR,': [662], 'receptor;': [666], 'Ig-like,': [667], 'immunoglobulin-like;': [668], 'TBS,': [669], 'Tris-buffered': [670, 1775], 'saline;': [671], 'CHO,': [672], 'Chinese': [673], 'hamster': [674], 'ovary;': [675], 'GFP,': [676], 'green': [677, 1558], 'fluorescent': [678, 1559], 'protein;': [679], 'm.o.i.,': [680], 'multiplicity': [681], 'infection;': [683], 'ERK,': [684], 'signal-regulated': [686], 'kinase;': [687], 'MAP,': [688], 'mitogen-activated': [689], 'was': [691, 1308, 1398, 1562, 1577, 1594, 1748, 1811, 1900, 1938, 1977, 2009, 2025, 2047, 2071, 2104, 2131, 2188, 2207, 2230, 2249, 2401, 2578, 2658, 2702, 2712, 3021, 3102, 3276, 3476, 3480, 3523, 3791], 'originally': [692], 'identified': [693], 'mutated': [697], 'patients': [699], 'autosomal': [701], 'dominant': [702], 'hypophosphatemic': [703], 'rickets': [704], '(6The': [705], 'ADHR': [706], 'Consortium': [707], 'Nat.': [708], 'Genet.': [709], '2000;': [710, 1857, 3867], '26:': [711], '345-348Crossref': [712], '(1281)': [715], 'where': [718, 2409], 'mutations': [719], 'conferred': [724], 'inactivation': [727, 1339], 'protease': [729, 2067], 'cleavage,': [730], 'resulting': [731], 'elevated': [733], 'serum': [734, 1190, 1424], 'levels': [735, 1191, 2904], '(7White': [738], 'K.E.': [739, 800, 882, 1031, 1078, 3373], 'Carn': [740], 'G.': [741, 808, 2637, 3893], 'Lorenz-Depiereux': [742], 'B.': [743, 3897], 'Benet-Pages': [744], 'Strom': [746], 'T.M.': [747], 'Econs': [748, 819, 889], 'M.J.': [749, 820, 890], 'Kidney': [750, 944, 1140, 2040, 3339], 'Int.': [751, 945, 1141, 3340], '2001;': [752], '60:': [753], '2079-2086Abstract': [754], '(440)': [762], '8Liu': [765], 'Guo': [767], 'Simpson': [769], 'L.G.': [770], 'Xiao': [771], 'Z.S.': [772], 'Burnham': [773], 'C.E.': [774], 'Quarles': [775], 'L.D.': [776, 908], '2003;': [780, 829, 899, 912], '278:': [781], '37419-37426Abstract': [782], '(430)': [790], '9Jonsson': [793], 'K.B.': [794], 'Zahradnik': [795], 'Larsson': [797], 'White': [799, 881, 1030, 1077, 3372], 'Sugimoto': [801], 'Imanishi': [803], 'Hampson': [807], 'Koshiyama': [809], 'Ljunggren': [811], 'Oba': [813], 'Yang': [815], 'I.M.': [816], 'Miyauchi': [817], 'Lavigne': [821], 'Juppner': [823], 'Engl.': [826], 'Med.': [828], '348:': [830], '1656-1663Crossref': [831], '(769)': [834], '10Yamazaki': [837], 'Okazaki': [839], 'Shibata': [841], 'Hasegawa': [843, 981, 1200], 'Satoh': [845, 3819], 'Tajima': [847], 'Takeuchi': [849, 983, 1202, 1353], 'Fujita': [851, 985, 1204, 1355], 'Nakahara': [853], 'Yamashita': [855, 991, 1210, 1359], 'Fukumoto': [857, 987, 1206, 1357], 'Clin.': [860, 897, 994, 1213, 3826], 'Endocrinol.': [861], 'Metab.': [862, 3909], '2002;': [863, 1101, 1230, 1362, 3396], '87:': [864], '4957-4960Crossref': [865], '(579)': [868], '11Riminucci': [871], 'Collins': [873], 'M.T.': [874], 'Fedarko': [875], 'N.S.': [876], 'Cherman': [877], 'Corsi': [879], 'Waguespack': [883], 'Gupta': [885], 'Hannon': [887], 'Bianco': [891], 'Gehron': [893], 'Robey': [894], 'Invest.': [898, 995, 1214, 3827], '112:': [900], '683-692Crossref': [901], '(543)': [904], '12Quarles': [907], 'Am.': [909], 'Physiol.': [911], '285:': [913], 'E1-E9Crossref': [914], '(286)': [917], 'inhibits': [921], 'phosphate': [922, 971, 1124, 1193, 3007, 3764], 'transport': [923, 1125], 'renal': [925, 970, 3011], 'proximal': [926, 931, 1127, 3755], 'tubular': [927, 3012], 'cells': [928, 1120, 1408, 1411, 1428, 1444, 1475, 1624, 1627, 1673, 1741, 1943, 1952, 2024, 2206, 2220, 2223, 2245, 2248, 2275, 2353, 2391, 2530, 2801, 2804, 2854, 2899, 2921, 3046, 3083, 3092, 3127, 3566, 3581, 3589], 'tubules': [932, 1128, 3631, 3756], 'perfused': [933, 1129], 'vitro': [935, 1131], '(13Baum': [936, 1132, 3331], 'Schiavi': [938, 1134, 3333], 'Dwarakanath': [940, 1136, 3335], 'V.': [941, 1137, 3336], 'Quigley': [942, 1138, 3337], '68:': [947, 1143, 3342], '1148-1153Abstract': [948, 1144, 3343], '(128)': [956, 1152, 3351], 'Consistent': [959, 2913], 'these': [961, 2752, 2915, 2970, 3511, 3837], 'findings,': [962, 2916], 'defective': [964, 3796], 'expression': [967, 1300, 1481, 1744, 1949, 2228, 2282, 2395, 2543], 'increased': [969, 1189, 2777, 3806], 'reabsorption': [972, 3008], 'hyperphosphatemia': [974], '(14Shimada': [975, 1194], 'Kakitani': [977, 1196], 'Yamazaki': [979, 1198, 1349], 'Tomizuka': [989, 1208], '113:': [997, 1216], '561-568Crossref': [998, 1217], '(1273)': [1001, 1220], 'Although': [1004], '(FGFRs)': [1011], '(15Yu': [1012, 1059], 'X.': [1013, 1060, 3355], 'Ibrahimi': [1014, 1061, 3356], 'O.A.': [1015, 1062, 3357], 'Goetz': [1016, 1063, 3358], 'Zhang': [1018, 1065, 3360], 'F.': [1019, 1066, 2635, 3361, 3851], 'Davis': [1020, 1067, 3362], 'S.I.': [1021, 1068, 3363], 'Garringer': [1022, 1069, 3364], 'H.J.': [1023, 1070, 3365], 'Linhardt': [1024, 1071, 3366], 'R.J.': [1025, 1072, 3367], 'Ornitz': [1026, 1073, 3368], 'D.M.': [1027, 1074, 2625, 3369], 'Mohammadi': [1028, 1075, 3370], 'Endocrinology.': [1032, 1079, 1229, 1361, 3374], '146:': [1034, 1081, 3376], '4647-4656Crossref': [1035, 1082, 3377], '(177)': [1038, 1085, 3380], 'it': [1041, 2783, 3112, 3613, 3750], 'modest': [1043], '(KD': [1046], '=': [1047, 1638, 1644], '200–700': [1048], 'nm)': [1049], 'often': [1051], 'requires': [1052, 3165, 3319], 'cofactors': [1053, 2987], 'such': [1054, 3488], 'heparin': [1056, 2872, 3321], 'glycosaminoglycan': [1058, 3323], '16Yamashita': [1088, 3383], 'Konishi': [1090, 3385], 'Miyake': [1092, 3387], 'Inui': [1094, 3389], 'Itoh': [1096, 3391], '277:': [1102, 3397], '28265-28270Abstract': [1103, 3398], '(192)': [1111, 3406], 'Scholar)': [1113, 1864, 3672], 'activate': [1115, 2791, 3146, 3168], 'cultured': [1119], 'inhibit': [1123, 3763], '(Klotho–/–': [1157], 'mice)': [1158, 1164], 'deficient': [1161], '(Fgf23–/–': [1163], 'retardation,': [1174], 'infertility,': [1175], 'hypoglycemia,': [1178], 'vascular': [1180], 'calcification': [1181, 3198], 'kidneys.': [1184], 'Notably,': [1185], 'they': [1186], 'both': [1187, 1321, 2975], 'have': [1188, 1240, 3928], '17Yoshida': [1223], '143:': [1231, 1363], '683-689Crossref': [1232], '(169)': [1235], 'led': [1241], 'us': [1242], 'hypothesis': [1245, 2439], 'via': [1252], 'pathway.': [1257], 'this': [1259, 2796], 'report': [1260], 'FGFRs': [1268, 1287, 1747, 1894, 2036, 2467, 2551, 2577, 2675, 2686, 2691, 2697, 2918, 2955, 3516, 3558], 'necessary': [1274, 2988], 'Expression': [1281, 1330], 'Vectors—Complementary': [1282], 'DNA': [1283], 'containing': [1284, 1685, 1778, 2066, 2304], 'mouse': [1286, 1334, 1374, 1381, 1550, 1946, 2044, 2197, 2279, 2398, 3025], 'coding': [1288], 'region': [1289], '(IMAGE': [1290], 'Clone,': [1291], 'Invitrogen,': [1292], 'supplemental': [1293, 3158], 'Fig.': [1294, 2966, 3028, 3159, 3287, 3573], '1)': [1295, 2583], 'were': [1296, 1383, 1412, 1429, 1460, 1476, 1612, 1628, 1674, 1770, 1791, 1880, 1953, 2158, 2261, 2297, 2322, 2358, 2414, 2586, 2878, 2905, 2922], 'cloned': [1297, 1384], 'into': [1298, 1385, 1564, 1579, 1596], 'pcDNA3.1(+)': [1299], 'vector': [1301, 1387, 1482, 1576, 1593, 2283, 2396], '(Invitrogen).': [1302], 'Before': [1303], 'subcloning,': [1304], 'V5-epitope': [1306, 2201], 'tag': [1307, 1397, 1556, 2202], 'added': [1309, 1399], 'C': [1312, 1402, 1806], 'terminus': [1313], 'appropriate': [1315], 'restriction': [1316], 'enzyme': [1317], 'sites': [1318], 'ends': [1322], 'using': [1323, 1484, 1604, 1967, 2170, 2333, 2419, 2880], 'synthetic': [1324], 'oligonucleotides': [1325], 'polymerase': [1327], 'chain': [1328], 'reaction.': [1329], 'vectors': [1331, 1745, 2229, 2544], 'resistant': [1336], 'proteolytic': [1338], '(R179Q)': [1340, 1948, 2281, 2400], '(18Shimada': [1341], 'Muto': [1343], 'Urakawa': [1345], 'Yoneya': [1347], 'Okawa': [1351], '3179-3182Crossref': [1364], '(384)': [1367], 'Klotho,': [1375, 3317, 3804], 'pEF1': [1386], '(Invitrogen)': [1388, 1466, 1489, 1868], 'same': [1391, 1433, 1906, 2015, 2162, 2314, 2958], 'way': [1392, 1907, 2163], 'except': [1393, 1409], 'FLAG-epitope': [1396], 'terminus.': [1403], 'Cell': [1404, 3908], 'Culture': [1405], 'Transfection—All': [1407], 'PC12': [1410, 1427, 1626, 3051], 'maintained': [1413, 1430], "Dulbecco's": [1415], 'modified': [1416], "Eagle's": [1417], 'medium': [1418, 1434, 1937, 1961, 1976, 1995, 2020, 2242, 2272, 2388], 'supplemented': [1419, 2284], '10%': [1421, 1437], 'fetal': [1422], 'bovine': [1423], 'penicillin/streptomycin.': [1426], 'additional': [1436], 'horse': [1438], 'serum.': [1439], 'Stable': [1440], 'transformants': [1441, 3079], '293': [1443, 1942, 2023, 2205, 2219, 2244, 2274, 2390, 2803, 2839, 3124], 'expressing': [1445, 1633, 3065, 3084], 'full-length': [1447, 1503, 1546, 2535, 2926, 2962, 2977, 3067, 3086], '(293KL)': [1452], '(293KLΔTM)': [1459], 'isolated': [1461], 'after': [1462, 2079], 'selection': [1463], 'G418': [1465], '14': [1468], 'days.': [1469], 'Subconfluent': [1470, 1622], '293,': [1471, 2349], '293KL,': [1472, 2350], '293KLΔTM': [1474, 1740, 2247, 2352, 2898, 3565, 3580], 'transfected': [1477, 1742, 2224, 2276, 2392, 2528], 'plasmids': [1483], 'Lipofectamine': [1486], 'transfection': [1487], 'reagent': [1488], 'according': [1490], "manufacturer's": [1493], 'protocol.': [1494], 'A': [1495], 'CHO': [1496, 3082], 'cell': [1497, 1600, 1671, 1898, 2412], 'line': [1498, 1601], 'stably': [1500, 2532], 'expresses': [1501], '(CHOKL)': [1505], 'gift': [1508], 'from': [1509, 2021, 2037, 2041, 3057], 'Kyowa': [1510], 'Hakko': [1511], 'Kogyo': [1512], 'Co.': [1513], 'Ltd.': [1514], '(5Imura': [1515, 3442], 'Adenovirus': [1541], 'Construction—A': [1542], 'cDNA': [1543], 'encoding': [1544], 'C-terminal': [1554, 2606], 'myc-eptope': [1555], '(GFP)': [1561], 'inserted': [1563], 'cloning': [1567], 'site': [1568], 'pShuttle-CMV': [1570], '(Qbiogene).': [1571], 'After': [1572], 'linearization,': [1573], 'shuttle': [1575], 'introduced': [1578, 1595], 'electroporation-competent': [1581], 'Escherichia': [1582], 'coli': [1583], 'BJ5183-AD-1': [1584], 'harboring': [1585], 'adenoviral': [1587], 'backbone': [1588], 'pAdEasy-1': [1589], '(Stratagene).': [1590], 'recombinant': [1592, 1987, 2006, 2368, 2809], 'adenovirus': [1598, 1632, 3064], 'packaging': [1599], 'QBI-HEK293A': [1602, 1620], '(Qbiogene)': [1603], 'FuGENE': [1605], '6': [1606], '(Roche': [1607], 'Applied': [1608], 'Science).': [1609], 'viruses': [1611], 'amplified': [1613], 'several': [1615], 'rounds': [1616], 'infection': [1618], 'HeLa': [1623, 1641, 3053], 'infected': [1629, 3050], 'GFP': [1636], '(m.o.i.': [1637], '3': [1639, 1766, 2238, 2257, 2293, 2825], 'm.o.i.': [1643], '10': [1645, 2004], 'PC12)': [1647], '36': [1648], 'h': [1649, 2124, 2152], 'before': [1650], 'stimulation': [1651], 'then': [1655, 1870, 1912, 2088, 2268, 2309, 2362, 3070], 'subjected': [1656, 1798, 1963, 2329, 2415], 'immunoblot': [1658, 1965, 2168, 2331, 2417, 3434], 'analysis': [1659, 1966, 2169, 2332, 2418, 3435], 'pathway': [1663], 'described': [1665, 1692, 1909, 2165, 3191], 'below.': [1666], 'Immunoprecipitation': [1667], 'Immunoblotting—To': [1669], 'prepare': [1670], 'lysate,': [1672], 'snap-frozen': [1675], 'liquid': [1677], 'nitrogen': [1678], 'lysed': [1680], 'lysis': [1683], 'buffer': [1684, 1796, 2054, 2303, 2315, 2327], 'inhibitors': [1686], 'phosphatase': [1688], 'proteinase': [1690], 'previously': [1693], 'lysate': [1736, 1899, 2130, 2176], '293KL': [1738, 1896, 1951, 2222, 2529, 2800, 2853, 2883, 2911, 2920, 3126, 3588], 'incubated': [1749, 1812, 2072, 2132, 2269], 'agarose': [1751], 'beads': [1752, 1769, 1790, 2157, 2260, 2296, 2321], 'conjugated': [1753, 2114, 2139], 'anti-V5': [1755, 1866, 2334], 'antibody': [1756, 1760, 1817, 1867, 2145, 2183, 2339, 2421, 2428, 2433], '(Sigma)': [1757, 1761], 'anti-FLAG': [1759], 'at': [1762, 2076, 2093, 2125, 2153, 2234, 2253, 2289], '4': [1763, 2077, 2126, 2154, 2235, 2254, 2290], '°C': [1764, 2078, 2236, 2255, 2291], 'h.': [1767, 2239, 2258, 2294], 'washed': [1771, 1789, 2262, 2298, 2320], 'three': [1772, 1784, 2299, 2310, 2489], 'times': [1773, 1785, 2098, 2264, 2300, 2311, 2867], 'saline': [1776], '(TBS)': [1777], '1%': [1779, 2305], 'Triton': [1780, 2083, 2287, 2306, 2317], 'X-100': [1781, 2084, 2288, 2307], '(TBST)': [1782], 'TBS.': [1787], 'suspended': [1792, 2323], 'SDS-sample': [1794, 2325], 'loading': [1795, 2326], 'SDS-PAGE.': [1800], 'transferred': [1803], 'Hybond': [1805], 'Extra': [1807], 'membrane': [1808], '(Amersham': [1809, 1876, 2112], 'Biosciences)': [1810, 2113], 'anti-Klotho': [1814, 2182], 'rat': [1815], 'monoclonal': [1816], 'KM2119': [1818, 2171], '(19Kato': [1819], 'Arakawa': [1821], 'Kinoshita': [1823], 'Shirai': [1825], 'Furuya': [1827, 3817], 'Yamano': [1829], 'Nakamura': [1831], 'Anazawa': [1835], 'Koh': [1837], 'Imura': [1841], 'Hanai': [1847], 'Takeshige': [1849], '267:': [1858], '597-602Crossref': [1859], '(132)': [1862], 'horseradish': [1872], 'peroxidase-linked': [1873], 'secondary': [1874], 'antibodies': [1875, 1915], 'Biosciences).': [1877], 'detected': [1881, 3429], 'SuperSignal': [1883], 'West': [1884], 'Dura': [1885], 'system': [1886, 3951], '(Pierce).': [1887], 'For': [1888], 'detecting': [1889], 'binding': [1891, 2618, 2682, 2778, 3262, 3486, 3514], 'endogenous': [1893, 2917, 3017], 'cells,': [1897, 3054], 'immunoprecipitated': [1901, 2180, 2554], 'anti-FLAG-agarose': [1903, 2252], 'above': [1910, 2166], 'immunoblotted': [1913], 'against': [1916], 'FGFR1': [1917, 2480], '(Santa': [1918, 1922], 'Cruz': [1919, 1923], 'Biotechnology),': [1920, 1924], 'FGFR2': [1921, 2482, 2657], 'FGFR3': [1925], '(Sigma),': [1926], 'KM2119.': [1928], 'Preparation': [1929], 'Conditioned': [1931, 2387], 'Medium': [1932], 'Containing': [1933], '(R179Q)—Serum-free': [1935], 'conditioned': [1936, 1960, 1975, 1994, 2019, 2241, 2271], 'prepared': [1939], 'transfecting': [1941], 'vector.': [1950], 'stimulated': [1954, 2799, 3071, 3077, 3123], 'doses': [1957, 3130], 'anti-phospho-ERK': [1968], 'antibody.': [1969, 2174], 'activity': [1972, 1999, 3034, 3116, 3257, 3421], 'determined': [1978, 3770], 'comparing': [1980], 'induced': [1985], 'known': [1991, 2615], 'concentrations.': [1992], 'equivalent': [2000], 'ng/ml': [2005], 'experiments.': [2013], 'amount': [2016], 'serum-free': [2018], 'mock-transfected': [2022], 'negative': [2029], 'control.': [2030], 'Co-precipitation': [2031], 'Endogenous': [2033], 'Mouse': [2038], 'Kidney—': [2039], '129': [2043], '(200': [2045], 'mg)': [2046], 'homogenized': [2048], '2': [2050], 'ml': [2051], 'homogenizing': [2053], '(20': [2055], 'mm': [2056, 2061, 2064], 'HEPES,': [2057], 'pH': [2058], '7.4,': [2059], '100': [2060, 2376], 'NaCl,': [2062], '0.5': [2063], 'EDTA)': [2065], 'inhibitors.': [2068], 'homogenate': [2070], '30': [2074], 'min': [2075, 2092], 'addition': [2081], '(final': [2085], '1%)': [2086], 'centrifuged': [2089], '12': [2091], '18,000': [2094], '×': [2095], 'g': [2096], 'two': [2097, 2487, 2881, 3431], 'remove': [2100], 'debris.': [2101], 'supernatant': [2103], 'precleared': [2105, 2129], '40': [2107], 'μl': [2108, 2135], 'A-Sepharose': [2111, 2138], '20': [2116, 2134], 'μg': [2117, 2142], 'normal': [2119, 2147], 'rabbit': [2120, 2148], 'IgG': [2121, 2149], '2.5': [2123, 2151], '°C.': [2127, 2155], '16': [2141], 'anti-FGFR1': [2144, 2173], 'processed': [2159], 'kidney': [2179, 3026], 'KL11-A': [2184], '(Alpha': [2185], 'Diagnostic': [2186], 'International)': [2187], 'positive': [2192, 2211], 'control': [2193, 2212], 'Klotho.': [2195, 2556, 2710, 2738], 'FGFR1c': [2198], 'FGFR1.': [2214], 'Pull-down': [2216], 'Experiments—Lysate': [2217], 'applied': [2231, 2250], 'anti-V5-agarose': [2233], 'Serum-free': [2240], 'four': [2263], 'TBST': [2266], '0.5%': [2286], 'Krebs-Ringer-HEPES': [2302], 'without': [2316, 2868], 'X-100.': [2318], 'antibody,': [2335], 'KM2119,': [2336], 'anti-FGF23': [2338], '(R&D': [2340], 'Systems).': [2341], 'Immunoblot': [2342], 'Analysis': [2343], 'Signaling': [2347], 'Pathway—Subconfluent': [2348], 'grown': [2354], 'on': [2355, 2969, 3271, 3284, 3307, 3501, 3546, 3753, 3938], '6-well': [2356], 'plates': [2357], 'serum-starved': [2359], 'overnight': [2360], 'treated': [2363], 'concentrations': [2366], '(0,': [2371], '0.1,': [2372], '1,': [2373], '10,': [2374], 'ng/ml,': [2377], 'Genzyme),': [2378], 'acidic': [2379, 3132, 3272], 'basic': [2381, 3134, 3152, 3274], '(Upstate)': [2383], '15': [2385], 'min.': [2386], 'source': [2406], 'indicated.': [2410], 'lysates': [2413], 'antiphospho-FRS2-α': [2420], '(Cell': [2422, 2429, 2434], 'Signaling),': [2423, 2430], 'anti-phospho-p44/42': [2424], 'MAP': [2425, 2822], 'kinase': [2426, 2823], '(ERK1/2)': [2427], 'anti-ERK': [2432], 'Signaling).': [2435], 'could': [2452, 3775], 'bind': [2454, 2672, 2736], 'FGFRs.': [2456, 3512], 'Four': [2457], 'tyrosine': [2459], 'kinases': [2460], 'designated': [2462], 'high': [2465, 3484, 3554], '(FGFR1–4).': [2468], 'Alternative': [2469, 2494], 'RNA': [2470], 'splicing': [2471, 2495], 'generates': [2472], 'isoforms.': [2475, 2594], 'composed': [2484], 'either': [2486], 'immunoglobulin-like': [2490], '(Ig-like)': [2491], 'ligand-binding': [2492, 2612], 'domains.': [2493], 'third': [2498, 2610], 'Ig-like': [2499, 2611], 'exists': [2501], 'FGFR1–3,': [2503], 'generating': [2504], '“b”': [2505], '“c”': [2507], 'isoforms': [2508, 2563, 2585, 2601], '(20Eswarakumar': [2509], 'V.P.': [2510], 'Lax': [2511], 'Schlessinger': [2513], 'Cytokine': [2515], 'Growth': [2516], 'Factor': [2517], 'Rev.': [2518], '16:': [2520], '139-149Crossref': [2521], '(1503)': [2524], 'We': [2527, 2728, 2942, 3122, 3468, 3561], 'asked': [2546], 'if': [2547], 'any': [2548], 'would': [2552], 'bound': [2558, 2951], 'almost': [2560], 'all': [2561, 3177], 'tested': [2564, 2729], '(Fig.': [2565, 2726, 2755, 2855, 2900, 2940, 2997, 3104, 3155, 3436, 3494, 3536, 3590, 3606], '1).': [2566], 'significant': [2568], 'difference': [2569, 2596], 'co-precipitate': [2576], 'between': [2580, 2597, 2690, 3016, 3291, 3557], 'isoforms:': [2582], 'c': [2584, 2600], 'more': [2587], 'efficiently': [2588, 2660], 'co-precipitated': [2589, 2661, 2923, 3481], 'b': [2593, 2598], 'located': [2603], 'half': [2607], 'affect': [2617, 2688, 3114], 'FGFs': [2621, 3118, 3260, 3310], 'well': [2623], '(21Ornitz': [2624], 'Xu': [2626], 'Colvin': [2628], 'J.S.': [2629], 'McEwen': [2630], 'D.G.': [2631], 'MacArthur': [2632], 'C.A.': [2633], 'Coulier': [2634], 'Gao': [2636], 'Goldfarb': [2638], '1996;': [2643], '271:': [2644], '15292-15297Abstract': [2645], '(1423)': [2653], '2)': [2656], 'less': [2659], 'FGFR1,': [2665], 'FGFR3,': [2666], 'FGFR4.': [2668], 'different': [2677, 3440], 'affinity.': [2678], 'interaction': [2689, 2764, 3015, 3509, 3556], 'FGF23,': [2693], 'pull': [2699, 2748, 3533], 'down': [2700, 2714, 2749, 3534], 'examined': [2703], 'presence': [2706, 2723], 'absence': [2708, 3315], 'pulled': [2713], 'FGFR1c,': [2716, 3490], '-3c,': [2717, 3491], '-4': [2719, 3493], 'only': [2720], '2).': [2727, 2756, 2967, 3537], 'might': [2734, 2784, 3041, 3576], 'alone': [2745], 'failed': [2746, 2830], 'under': [2751], 'experimental': [2753], 'conditions': [2754], 'indicate': [2759], 'stronger': [2763], 'Since': [2775, 3106, 3623], 'FGFRs,': [2782, 3111, 3265], 'enhance': [2785, 3038, 3142], 'possibility,': [2797], 'concentration': [2807], 'compared': [2813, 3279], 'substrate-2α': [2818], '(FRS2α)': [2819], 'p44/42': [2821], '(ERK1/2).': [2824], 'nm': [2826, 2844], '(100': [2827], 'ng/ml)': [2828, 2846], 'FRS2α': [2835, 2849, 2893], 'ERK1/2': [2837, 2851], 'contrast,': [2842], '0.3': [2843], '3A),': [2856], 'indicating': [2857, 3409], 'cellular': [2862, 3602], 'sensitivity': [2863, 3603], '>10': [2866], 'help': [2870, 3412], 'glycosaminoglycan.': [2874], 'results': [2877], 'obtained': [2879], 'independent': [2882], 'clones': [2884], '(data': [2885], 'shown).': [2887], 'FGF23-induced': [2892], '3B),': [2901], 'although': [2902, 3266], 'reduced': [2906], 'relative': [2907], 'and,': [2929], 'smaller': [2932], 'extent,': [2933], '3C).': [2941], 'confirmed': [2944], 'exogenously': [2953], 'pattern': [2959], 'did': [2964, 3140], '(supplemental': [2965, 3027, 3286, 3572], 'Based': [2968], 'observations,': [2971], 'conclude': [2973], 'efficient': [2990], '3D).': [2998], 'primary': [3000], 'suppress': [3006], 'Indeed,': [3014], '3).': [3029], 'action': [3040, 3154], 'non-kidney': [3045, 3091], 'well,': [3048], 'originated': [3056], 'pheochromocytoma': [3058], 'cervical': [3060], 'carcinoma,': [3061], 'respectively,': [3062], 'stable': [3078], 'ovary-derived': [3081], 'acquired': [3093], 'respond': [3097], 'when': [3100, 3278, 3478], '4).': [3105, 3160, 3288], 'other': [3119, 3309], 'found': [3137], 'their': [3143], 'but': [3149], 'slightly': [3150], 'suppressed': [3151], '3A': [3156], 'fact': [3162, 3593], 'explain': [3172, 3578], 'why': [3173, 3579], 'Klotho–/–': [3174, 3185, 3292], 'phenotypes': [3179, 3189, 3295, 3838], 'Fgf23–/–': [3182, 3193, 3294], 'mice,': [3194], 'ectopic': [3197], 'extra-renal': [3200], 'tissues,': [3201], 'neuronal': [3204], 'degeneration,': [3205], 'This': [3250], 'imply': [3252], 'affects': [3255], 'through': [3261], 'effect': [3268, 3283], 'small': [3277], 'robust': [3282], 'Precise': [3289], 'comparison': [3290], 'provide': [3297], 'clue': [3299], 'understanding': [3301, 3945], 'potential': [3303], 'effects': [3304], 'besides': [3311], 'exogenous': [3320], 'stimulate': [3328], '15Yu': [3354], 'sugar': [3414, 3499, 3544], 'chains': [3415], 'critical': [3417], 'biological': [3420], 'glycoprotein': [3427], 'bands': [3432], '1),': [3437, 3495], 'represent': [3439], 'glycosylation': [3441], 'noticed': [3469, 3563], 'upper': [3472, 3503, 3519], 'band': [3473, 3504, 3520, 3571], 'enriched': [3477], 'partners': [3487], 'suggesting': [3496], 'chain(s)': [3500, 3545], 'facilitate': [3508], 'Furthermore,': [3513], 'associated': [3524], 'It': [3538, 3766, 3790], 'possible': [3540], 'particular': [3543], 'lower': [3570], '2),': [3574], 'showed': [3582, 3805], 'weaker': [3583], 'response': [3584], '3B).': [3591], 'can': [3600], 'increase': [3601], '3B)': [3607], 'raised': [3609], 'paracrine': [3618, 3779], 'distal': [3629], 'convoluted': [3630], 'act': [3752], 'adjacent': [3754], 'work': [3758], 'cooperatively': [3759], 'reabsorption.': [3765], 'peptide': [3774], 'and/or': [3780], 'endocrine': [3782], 'regulation': [3786, 3932], 'recently': [3792], 'reported': [3793], 'βKlotho,': [3798], 'structurally': [3802], 'resembles': [3803], 'synthesis': [3807], 'excretion': [3809], 'bile': [3811], 'acids': [3812], '(22Ito': [3813], '115:': [3829], '2202-2208Crossref': [3830], '(200)': [3833], 'Interestingly,': [3836], 'identical': [3840], 'FGFR4': [3845], 'knock-out': [3846], '(23Yu': [3848], 'C.': [3849, 3855], 'Wang': [3850], 'Kan': [3852], 'Jin': [3854], 'Jones': [3856, 3894], 'R.B.': [3857], 'Weinstein': [3858], 'Deng': [3860], 'C.X.': [3861], 'McKeehan': [3862], 'W.L.': [3863], '275:': [3868], '15482-15489Abstract': [3869], '(310)': [3877], '24Inagaki': [3880], 'Choi': [3882], 'Moschetta': [3884], 'Peng': [3886], 'L.': [3887], 'Cummins': [3888], 'C.L.': [3889], 'McDonald': [3890], 'J.G.': [3891], 'Luo': [3892], 'S.A.': [3895, 3907], 'Goodwin': [3896], 'Richardson': [3898], 'J.A.': [3899], 'Gerard': [3900], 'R.D.': [3901], 'Repa': [3902], 'J.J.': [3903], 'Mangelsdorf': [3904], 'D.J.': [3905], 'Kliewer': [3906], '2:': [3911], '217-225Abstract': [3912], '(1342)': [3920], 'family': [3926], 'evolved': [3929], 'Further': [3936], 'studies': [3937], 'expected': [3941], 'promote': [3943], 'better': [3944], 'relation': [3954], 'aging.': [3956], 'Download': [3957], '.pdf': [3958], '(.6': [3959], 'MB)': [3960], 'Help': [3961], 'pdf': [3963], 'files': [3964]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2164533721', 'counts_by_year': [{'year': 2024, 'cited_by_count': 47}, {'year': 2023, 'cited_by_count': 40}, {'year': 2022, 'cited_by_count': 57}, {'year': 2021, 'cited_by_count': 64}, {'year': 2020, 'cited_by_count': 77}, {'year': 2019, 'cited_by_count': 79}, {'year': 2018, 'cited_by_count': 92}, {'year': 2017, 'cited_by_count': 62}, {'year': 2016, 'cited_by_count': 90}, {'year': 2015, 'cited_by_count': 73}, {'year': 2014, 'cited_by_count': 75}, {'year': 2013, 'cited_by_count': 92}, {'year': 2012, 'cited_by_count': 106}], 'updated_date': '2024-12-10T01:37:38.460487', 'created_date': '2016-06-24'}