Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2164343224', 'doi': 'https://doi.org/10.1152/ajpendo.00444.2005', 'title': 'Effects of streptozotocin-induced diabetes and physical training on gene expression of extracellular matrix proteins in mouse skeletal muscle', 'display_name': 'Effects of streptozotocin-induced diabetes and physical training on gene expression of extracellular matrix proteins in mouse skeletal muscle', 'publication_year': 2005, 'publication_date': '2005-12-14', 'ids': {'openalex': 'https://openalex.org/W2164343224', 'doi': 'https://doi.org/10.1152/ajpendo.00444.2005', 'mag': '2164343224', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16352670'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpendo.00444.2005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196637695', 'display_name': 'AJP Endocrinology and Metabolism', 'issn_l': '0193-1849', 'issn': ['0193-1849', '1522-1555'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087514509', 'display_name': 'Maarit Lehti', 'orcid': 'https://orcid.org/0000-0002-9063-6541'}, 'institutions': [{'id': 'https://openalex.org/I4210148053', 'display_name': 'LIKES – Foundation for Sport and Health Sciences', 'ror': 'https://ror.org/03mahcv92', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210148053']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'T Maarit Lehti', 'raw_affiliation_strings': ['LIKES Research Center for Sport and Health Sciences, Rautpohjankatu 8, Viveca, FIN-40700 Jyväskylä, Finland. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'LIKES Research Center for Sport and Health Sciences, Rautpohjankatu 8, Viveca, FIN-40700 Jyväskylä, Finland. [email protected]', 'institution_ids': ['https://openalex.org/I4210148053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058069617', 'display_name': 'Mika Silvennoinen', 'orcid': 'https://orcid.org/0000-0002-5389-8251'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mika Silvennoinen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026249203', 'display_name': 'Riikka Kivelä', 'orcid': 'https://orcid.org/0000-0002-2686-8890'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Riikka Kivelä', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062099550', 'display_name': 'Heikki Kainulainen', 'orcid': 'https://orcid.org/0000-0001-5102-4350'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Heikki Kainulainen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110600809', 'display_name': 'Jyrki Komulainen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jyrki Komulainen', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.557, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 31, 'citation_normalized_percentile': {'value': 0.881917, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '290', 'issue': '5', 'first_page': 'E900', 'last_page': 'E907'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11068', 'display_name': 'Tendon Structure and Treatment', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis Treatment and Mechanisms', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.7390461}, {'id': 'https://openalex.org/C2779959927', 'wikidata': 'https://www.wikidata.org/wiki/Q1048687', 'display_name': 'Skeletal muscle', 'level': 2, 'score': 0.67065585}, {'id': 'https://openalex.org/C2779814568', 'wikidata': 'https://www.wikidata.org/wiki/Q58345', 'display_name': 'Laminin', 'level': 3, 'score': 0.6483135}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.5863457}, {'id': 'https://openalex.org/C2779280383', 'wikidata': 'https://www.wikidata.org/wiki/Q257331', 'display_name': 'Streptozotocin', 'level': 3, 'score': 0.581057}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.52732056}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5073499}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.49338213}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.48431817}, {'id': 'https://openalex.org/C2779869378', 'wikidata': 'https://www.wikidata.org/wiki/Q409747', 'display_name': 'Elastin', 'level': 2, 'score': 0.44243652}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.34292626}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34266973}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.340431}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.31869757}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.27515313}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.22748005}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20231742}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.15225562}], 'mesh': [{'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010805', 'descriptor_name': 'Physical Conditioning, Animal', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001835', 'descriptor_name': 'Body Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001835', 'descriptor_name': 'Body Weight', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002950', 'descriptor_name': 'Citrate (si)-Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002950', 'descriptor_name': 'Citrate (si)-Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055513', 'descriptor_name': 'Connective Tissue Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008815', 'descriptor_name': 'Mice, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010805', 'descriptor_name': 'Physical Conditioning, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpendo.00444.2005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196637695', 'display_name': 'AJP Endocrinology and Metabolism', 'issn_l': '0193-1849', 'issn': ['0193-1849', '1522-1555'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16352670', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.75, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1520047600', 'https://openalex.org/W1828498691', 'https://openalex.org/W1894013742', 'https://openalex.org/W1963648288', 'https://openalex.org/W1968204641', 'https://openalex.org/W1969956117', 'https://openalex.org/W1970680464', 'https://openalex.org/W1971190465', 'https://openalex.org/W1981718074', 'https://openalex.org/W1982527591', 'https://openalex.org/W1986679086', 'https://openalex.org/W1989159761', 'https://openalex.org/W2006431693', 'https://openalex.org/W2007755400', 'https://openalex.org/W2008213605', 'https://openalex.org/W2025361420', 'https://openalex.org/W2034282738', 'https://openalex.org/W2034714028', 'https://openalex.org/W2042050203', 'https://openalex.org/W2047393436', 'https://openalex.org/W2048393160', 'https://openalex.org/W2050928977', 'https://openalex.org/W2053352199', 'https://openalex.org/W2057414952', 'https://openalex.org/W2061201411', 'https://openalex.org/W2069734283', 'https://openalex.org/W2075303668', 'https://openalex.org/W2075556097', 'https://openalex.org/W2087749727', 'https://openalex.org/W2088143374', 'https://openalex.org/W2110205828', 'https://openalex.org/W2112711019', 'https://openalex.org/W2115438428', 'https://openalex.org/W2118435007', 'https://openalex.org/W2134024560', 'https://openalex.org/W2146007051', 'https://openalex.org/W2146350838', 'https://openalex.org/W2147666406', 'https://openalex.org/W2162838387', 'https://openalex.org/W2162871532', 'https://openalex.org/W2169448756', 'https://openalex.org/W2170723783', 'https://openalex.org/W2172145525', 'https://openalex.org/W2183853906', 'https://openalex.org/W2335205318', 'https://openalex.org/W2398042433', 'https://openalex.org/W2403610055', 'https://openalex.org/W4243484991'], 'related_works': ['https://openalex.org/W28694661', 'https://openalex.org/W2329916825', 'https://openalex.org/W2133212387', 'https://openalex.org/W2108819369', 'https://openalex.org/W2079276351', 'https://openalex.org/W2059378376', 'https://openalex.org/W2034771809', 'https://openalex.org/W2031028308', 'https://openalex.org/W1996532357', 'https://openalex.org/W1963749563'], 'abstract_inverted_index': {'Diabetes': [0, 93], 'induces': [1], 'changes': [2], 'in': [3, 13, 34, 124, 162], 'the': [4, 9, 18, 28, 89, 95, 142, 157, 160], 'structure': [5, 158], 'and': [6, 24, 48, 78, 107, 112, 148, 167], 'function': [7], 'of': [8, 20, 31, 63, 71, 98, 122, 134, 141, 150, 159], 'extracellular': [10], 'matrix': [11], '(ECM)': [12], 'many': [14], 'tissues.': [15], 'We': [16], 'investigated': [17], 'effects': [19], 'diabetes,': [21, 138], 'physical': [22, 135], 'training,': [23], 'their': [25], 'combination': [26], 'on': [27, 66], 'gene': [29, 96, 120], 'expression': [30, 70, 97, 121, 140], 'ECM': [32], 'proteins': [33], 'skeletal': [35, 126], 'muscle.': [36], 'Mice': [37], 'were': [38, 84], 'divided': [39], 'to': [40], 'control': [41], '(C),': [42], 'training': [43, 50, 65, 91], '(T),': [44], 'streptozotocin-induced': [45], 'diabetic': [46, 49, 125], '(D),': [47], '(DT)': [51], 'groups.': [52], 'Training': [53, 81], 'groups': [54], '(T,': [55], 'DT)': [56], 'performed': [57], '1,': [58], '3,': [59], 'or': [60], '5': [61], 'wk': [62], 'endurance': [64], 'a': [67, 132, 163], 'treadmill.': [68], 'Gene': [69], 'calf': [72], 'muscles': [73], 'was': [74, 128], 'analyzed': [75], 'using': [76], 'microarray': [77], 'quantitative': [79], 'PCR.': [80], 'group': [82], 'samples': [83], 'collected': [85], '24': [86], 'h': [87], 'after': [88], 'last': [90], 'session.': [92], 'affected': [94], 'several': [99], 'collagens': [100, 123, 146], '(types': [101], 'I,': [102], 'III,': [103], 'IV,': [104], 'V,': [105], 'VI,': [106], 'XV),': [108], 'some': [109], 'noncollagenous': [110, 151], 'glycoproteins,': [111], 'proteoglycans': [113], '(e.g.,': [114], 'elastin,': [115], 'thrombospondin-1,': [116], 'laminin-2,': [117], 'decorin).': [118], 'Reduced': [119], 'muscle': [127], 'partially': [129], 'attenuated': [130], 'as': [131], 'result': [133], 'training.': [136], 'In': [137], 'mRNA': [139], 'basement': [143], 'membrane': [144], '(BM)': [145], 'decreased': [147], 'that': [149], 'glycoproteins': [152], 'increased.': [153], 'This': [154], 'may': [155], 'change': [156], 'BM': [161], 'less': [164], 'collagenous': [165], 'direction': [166], 'affect': [168], 'its': [169], 'properties.': [170]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2164343224', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-13T17:54:54.621626', 'created_date': '2016-06-24'}