Publication Information

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140, 150, 190, 231, 262, 305, 315, 325, 521, 1017, 1241, 1279, 1290, 1319, 1346, 1390, 1422, 1455, 1933, 2032, 2366, 2474, 2613, 2750, 2864, 2908, 3212, 3304, 3350, 3387, 3399, 3416, 3440, 3450, 3469, 3505, 3529, 3594, 3636, 3663, 3696, 3739, 3917, 3938, 3970, 4002, 4035, 4063, 4078, 4105], 'bacilli': [16, 57, 63, 191, 232, 238, 571, 618, 629, 742, 1242, 1280, 2909, 3219, 3451, 3461, 3533, 3664, 4003, 4036, 4064, 4081, 4240], 'are': [17, 192, 581, 630, 687, 1132, 1284, 1696, 2309, 2590, 3471, 4086], 'tolerant': [18, 193, 631], 'to': [19, 138, 171, 194, 313, 346, 532, 632, 683, 685, 887, 905, 909, 969, 1287, 1357, 1464, 1478, 1559, 1619, 1915, 2045, 2069, 2116, 2131, 2344, 2352, 2431, 2683, 2836, 2872, 2889, 2932, 2959, 3011, 3042, 3053, 3091, 3098, 3115, 3183, 3231, 3261, 3301, 3391, 3477, 3543, 3549, 3864, 3927, 3989, 4126, 4259, 4293, 4351], 'conventional': [20, 195], 'anti-tuberculosis': [21, 163, 196, 338], 'drugs,': [22, 197, 637, 2048], 'such': [23, 198, 499, 638, 976], 'as': [24, 34, 58, 60, 151, 153, 199, 209, 233, 235, 326, 328, 500, 639, 975, 1274, 1426, 1456, 1458, 1473, 1480, 1482, 1698, 1792, 1888, 1926, 1988, 2086, 2173, 2233, 2281, 2330, 2382, 2486, 2592, 2618, 2710, 2938, 3076, 3196, 3241, 3426, 3456, 3481, 3729, 3731, 3744, 3746, 3802, 3820, 3934, 4032, 4034, 4297, 4324, 4326], 'isoniazid.': [25, 200], 'We': [26, 116, 201, 291, 1316, 1415, 2861], 'recently': [27, 202], 'identified': [28, 203, 728], 'diarylquinoline': [29, 204, 554], 'R207910': [30, 54, 170, 205, 229, 345, 800, 818, 1380, 1425, 1453, 1472, 2448, 2545, 2716, 2757, 2858, 2871, 2884, 3019, 3184, 3257, 3335, 3397, 3410, 3444, 3478, 3524, 3555, 3579, 3690, 3737, 3752, 3814, 3852, 3920, 3962, 4013, 4132, 4140, 4211], '(also': [31, 206], 'called': [32, 207], 'TMC207)': [33, 208], 'an': [35, 210, 512, 663, 1230, 1237, 1375, 1418, 1616, 1975, 2916, 3016, 3249, 3254, 3563, 3581, 3598, 3620, 3950], 'inhibitor': [36, 211, 2917, 4250], 'ATP': [38, 75, 82, 92, 108, 121, 213, 250, 257, 267, 283, 296, 913, 959, 968, 1004, 1119, 1129, 1234, 1250, 1265, 1302, 1308, 1325, 1344, 1354, 1366, 1372, 1396, 1443, 1586, 1589, 1604, 1613, 2357, 2375, 2420, 2463, 2469, 2558, 2574, 2778, 2989, 3795, 3804, 4155, 4248, 4335], 'synthase': [39, 76, 93, 122, 214, 251, 268, 297, 1005, 1130, 1235, 1266, 1303, 1326, 1355, 1397, 1444, 1590, 1605, 1614, 2779, 2990, 3805, 4156, 4249], 'a': [41, 70, 112, 134, 216, 245, 287, 309, 427, 488, 614, 623, 729, 903, 1019, 1275, 1297, 1333, 1338, 1474, 1575, 1662, 1678, 1701, 2126, 2155, 2531, 2669, 2744, 2767, 2890, 2933, 2945, 2966, 2987, 2993, 3054, 3086, 3109, 3242, 3262, 3290, 3383, 3511, 3666, 3700, 3705, 3868, 3953, 3990, 4043, 4119, 4123, 4150, 4244, 4253, 4260], 'remarkable': [42, 217, 1466], 'activity': [43, 97, 123, 146, 218, 272, 298, 321, 739, 973, 2560, 3374, 3395, 3480, 3493, 3968, 3994, 4025], 'against': [44, 219, 520, 1378, 1777, 2962, 4060], 'replicating': [45, 154, 220, 329, 741, 1392, 1460, 3376, 3402, 3503, 3748, 3881, 4061, 4080], 'mycobacteria.': [46, 221], 'In': [47, 222, 1001, 1016, 1572, 2074, 2141, 2925, 3002, 3168, 3389, 3442, 3590, 3684, 3722, 4122, 4304], 'present': [49, 224, 3363], 'study,': [50, 225, 3170], 'we': [51, 84, 226, 259, 727, 1293, 1436, 2752, 3404, 3519, 3561, 3734, 3841, 4135], 'show': [52, 85, 227, 260, 1437, 3382], 'that': [53, 86, 118, 228, 261, 293, 461, 587, 735, 1111, 1318, 1327, 1364, 1395, 1438, 1611, 2947, 3282, 3468, 3736, 3813, 4083, 4239, 4289, 4309, 4349], 'kills': [55, 230, 3738], 'effectively': [59, 234, 1288, 1311, 3745], 'aerobically': [61, 236, 2209, 3146, 3433, 3459, 3531, 3883], 'grown': [62, 237, 1896, 2210, 2477, 3147, 3434, 3460, 3532, 3884], 'same': [66, 241, 4295], 'target': [67, 137, 242, 312, 1277, 1618, 2747, 4129, 4296, 4333], 'specificity.': [68, 243], 'Despite': [69, 244, 458], 'transcriptional': [71, 246, 4353], 'down-regulation': [72, 247, 1030, 1299], 'operon': [77, 252, 1131, 1304], 'and': [78, 110, 165, 253, 285, 340, 362, 426, 542, 620, 627, 666, 693, 746, 796, 901, 974, 1036, 1137, 1243, 1281, 1305, 1323, 1367, 1489, 1609, 1626, 1633, 1705, 1758, 1765, 1788, 1917, 2049, 2059, 2134, 2203, 2208, 2217, 2252, 2277, 2294, 2299, 2365, 2454, 2462, 2569, 2611, 2650, 2658, 2666, 2831, 2855, 3075, 3106, 3185, 3251, 3294, 3357, 3366, 3414, 3423, 3435, 3499, 3504, 3525, 3530, 3552, 3580, 3713, 3801, 3848, 3853, 3877, 3882, 3905, 3923, 3929, 4001, 4017, 4053, 4062, 4079, 4094, 4104, 4226, 4257, 4263, 4275], 'significantly': [79, 254, 3436], 'lower': [80, 255], 'cellular': [81, 256, 1307, 1371, 3818], 'levels,': [83, 258, 1309], 'mycobacteria': [88, 263, 593, 1114, 1320, 1347, 1423, 2964, 3113, 3177, 3338, 3486, 3595, 4312], 'do': [89, 264], 'possess': [90, 265], 'residual': [91, 120, 266, 295], 'enzymatic': [94, 269], 'activity.': [95, 270, 1360, 2073, 3861], 'This': [96, 271, 1550, 3061, 3466, 3750, 3862], 'blocked': [99, 274], 'by': [100, 275, 419, 577, 583, 634, 820, 1348, 1588, 1783, 1905, 1947, 1965, 2036, 2064, 2109, 2148, 2165, 2283, 2332, 2563, 2913, 3024, 3065, 3223, 3295, 3569, 3587, 3604, 3612, 3679, 3710, 3717, 3724, 3777, 3984, 4313], 'nanomolar': [101, 276], 'concentrations': [102, 277, 1973, 2124, 3155, 3728], 'R207910,': [104, 279, 2726, 4298], 'thereby': [105, 280], 'further': [106, 281, 2120, 3515, 3715], 'reducing': [107, 282], 'levels': [109, 284, 2360, 2421, 2464], 'causing': [111, 286, 671], 'pronounced': [113, 288], 'bactericidal': [114, 145, 289, 320, 383, 560, 635, 1359, 1450, 2072, 3373, 3394, 3407, 3479, 3727, 3759, 3913, 3967, 4072], 'effect.': [115, 290], 'conclude': [117, 292], 'this': [119, 294, 1002, 1268, 1557, 2307, 3340, 3517, 3537, 4216], 'indispensable': [125, 300], 'for': [126, 301, 469, 492, 516, 539, 548, 662, 810, 1011, 1118, 1249, 1401, 1410, 1593, 1661, 1834, 2106, 2125, 2161, 2170, 2301, 2442, 2459, 2481, 2554, 2746, 2867, 3180, 3438, 3501, 3910], 'survival': [128, 303, 3195], 'mycobacteria,': [131, 306, 1018, 1393, 3377, 3403], 'making': [132, 307], 'it': [133, 308, 1259, 2955, 3107, 3244, 3810], 'promising': [135, 310], 'drug': [136, 311, 1276, 1440, 1558, 1972, 2123, 3756], 'tackle': [139, 314], 'infections.': [141, 316, 1623], 'The': [142, 317, 411, 676, 1341, 1447, 1596, 1673, 2054, 2287, 2539, 2557, 2905, 4067, 4247, 4280], 'unique': [143, 318, 1448], 'dual': [144, 319, 1449], 'diarylquinolines': [148, 323, 733], 'on': [149, 324, 740, 1385, 1454, 2066, 2138, 2717, 2727, 2758, 3193, 3210, 3336, 3375, 3386, 3398, 3449, 3527, 3635, 3694, 3761, 3859, 3879, 3915, 3956, 3969, 3995, 4026, 4057, 4077, 4141, 4215, 4317], 'well': [152, 327, 1457, 3730, 3821, 4033, 4325], 'bacterial': [155, 330, 2211, 3104, 3637, 3763], 'subpopulations': [156, 331], 'distinguishes': [157, 332], 'them': [158, 333, 3381], 'entirely': [159, 334], 'from': [160, 335, 890, 979, 1639, 2129, 2267, 2428], 'current': [162, 337, 535, 1597], 'drugs': [164, 339, 518, 528], 'underlines': [166, 341], 'potential': [168, 343, 1009, 1388, 1405, 2601, 2677], 'shorten': [172, 347, 533], 'tuberculosis': [173, 348, 351, 415, 555, 1629, 1776, 2370, 2436, 2733, 2764, 2866, 3007, 3151, 3419, 3698, 3741, 3886, 4147], 'treatment.': [174, 349], 'infection': [352, 2969], 'results': [353, 4307], 'in': [354, 369, 429, 467, 496, 622, 657, 679, 744, 747, 805, 877, 956, 963, 1135, 1138, 1240, 1278, 1337, 1345, 1389, 1469, 1579, 1606, 1649, 1658, 1677, 1700, 1794, 1936, 2051, 2083, 2215, 2223, 2306, 2609, 2663, 2736, 2739, 2770, 2850, 2881, 2893, 2936, 2965, 3015, 3048, 3071, 3085, 3102, 3112, 3229, 3248, 3253, 3265, 3285, 3339, 3411, 3432, 3510, 3567, 3585, 3597, 3602, 3624, 3640, 3708, 3769, 3781, 3851, 3888, 3889, 3947, 3992, 4012, 4101, 4118, 4152, 4219, 4243, 4266, 4268, 4331, 4337, 4345], 'more': [355, 3045, 3430, 3447, 3473, 3617], 'than': [356, 1567, 3047], '2': [357, 2162, 3171, 3464], 'million': [358], 'deaths': [359], 'per': [360], 'year': [361], 'leading': [365, 3052], 'cause': [366], 'mortality': [368], 'people': [370], 'HIV': [373, 422], '2The': [374], 'abbreviations': [375], 'used': [376, 1409], 'are:': [377], 'HIVhuman': [378], 'immunodeficiency': [379, 552], 'virusDARQdiarylquinolineTBtuberculosisMICminimum': [380], 'inhibitory': [381, 557, 1770], 'concentrationMBCminimum': [382], 'concentrationWCCWayne': [384], 'cidal': [385, 563], 'concentrationCFUcolony-forming': [386], 'unitDCCDN,N′-dicyclohexylcarbodiimideDETA/NOdiethylenetriamine/nitric': [387], 'oxide.': [388, 569], '(1Dye': [389], 'C.': [390, 446, 782, 1093, 1188, 1524, 1741, 1870, 2814, 4190], 'Scheele': [391], 'S.': [392, 778, 1052, 1064, 1077, 1147, 1159, 1172, 1520, 1737, 1866, 2810, 3827, 4186], 'Dolin': [393], 'P.': [394, 752, 765, 771, 1494, 1507, 1513, 1711, 1724, 1730, 1840, 1853, 1859, 1994, 2784, 2797, 2803, 4160, 4173, 4179], 'Pathania': [395], 'V.': [396, 786, 1056, 1151, 1528, 1745, 1800, 1874, 2818, 4194], 'Raviglione': [397, 443], 'M.C.': [398, 444], 'J.': [399, 699, 713, 754, 763, 854, 937, 1096, 1191, 1213, 1216, 1496, 1505, 1713, 1722, 1842, 1851, 2190, 2404, 2508, 2786, 2795, 3132, 3320, 4162, 4171], 'Am.': [400], 'Med.': [401, 449, 1098, 1193, 1218, 2192, 3134, 3322], 'Assoc.': [402], '1999;': [403, 2980], '282:': [404], '677-686Crossref': [405], 'PubMed': [406, 453, 608, 649, 705, 721, 791, 865, 922, 948, 996, 1069, 1102, 1164, 1197, 1222, 1533, 1545, 1750, 1821, 1879, 2021, 2098, 2196, 2247, 2415, 2519, 2633, 2823, 2983, 3138, 3326, 3834, 4199], 'Scopus': [407, 454, 609, 650, 706, 722, 792, 866, 923, 949, 997, 1070, 1103, 1165, 1198, 1223, 1534, 1546, 1751, 1822, 1880, 2022, 2197, 2248, 2416, 2520, 2634, 2824, 3139, 3327, 3835, 4200], '(2744)': [408], 'Google': [409, 456, 611, 652, 708, 724, 794, 868, 925, 951, 999, 1072, 1105, 1167, 1200, 1225, 1536, 1548, 1753, 1824, 1882, 2024, 2099, 2199, 2250, 2418, 2522, 2636, 2826, 2984, 3141, 3329, 3837, 4202], 'Scholar).': [410, 457, 612, 653, 725, 869, 952, 1000, 1106, 1226, 1549, 1754, 1883, 2025, 2100, 2200, 2419, 2523, 2637, 2827, 2985, 3142, 3330, 3838, 4203], 'global': [412, 504], 'epidemic': [413], '(TB)': [416], 'fuelled': [418], 'co-infection': [420], 'patients': [423, 814], 'TB': [425, 431, 462, 486, 508, 541, 673, 1622, 3369, 3495, 3755], 'rise': [428], 'multidrug-resistant': [430, 816], 'strains': [432, 2833], '(2Corbett': [433], 'E.L.': [434, 1211], 'Watt': [435], 'C.J.': [436], 'Walker': [437], 'N.': [438, 784, 838, 917, 1526, 1743, 1872, 2388, 2492, 2816, 4192], 'Maher': [439], 'D.': [440, 774, 856, 928, 1075, 1170, 1516, 1733, 1862, 2179, 2406, 2510, 2806, 3121, 3309, 4182], 'Williams': [441, 770, 1512, 1729, 1858, 2802, 4178], 'B.G.': [442], 'Dye': [445], 'Arch.': [447], 'Int.': [448], '2003;': [450, 1099, 1194, 2193, 3135, 3323], '163:': [451], '1009-1021Crossref': [452], '(2224)': [455], 'fact': [460], 'control': [463, 505, 2745, 3186, 3200, 3939], 'programs': [464], 'have': [465, 1115, 1321, 3789], 'been': [466, 1027, 2957, 3096, 3279], 'place': [468], 'decades,': [470], 'approximately': [471], 'M.': [481, 767, 932, 1314, 1509, 1726, 1775, 1855, 2369, 2435, 2475, 2616, 2622, 2719, 2732, 2763, 2799, 2865, 3006, 3150, 3418, 3506, 3697, 3740, 3885, 3918, 4106, 4146, 4175], 'Reactivation': [483], 'latent': [485, 523, 549, 1621, 2963], 'high': [489], 'risk': [490], 'factor': [491], 'disease': [493], 'development,': [494], 'particularly': [495], 'immunocompromised': [497], 'individuals,': [498], 'HIV-infected': [501], 'patients.': [502], 'For': [503, 3536, 3558], 'epidemic,': [509], 'there': [510], 'urgent': [513], 'medical': [514], 'need': [515], 'new': [517, 545, 730, 3512, 4120], 'active': [519, 672, 1322, 3246, 3448], 'or': [522, 1391, 1832, 2546, 2842, 2847, 3547, 3794], 'bacilli.': [524, 1291, 3388, 3441, 3749], 'so-called': [526], 'sterilizing': [527, 1467], 'would': [529], 'be': [530, 1272, 1479, 2879, 2960, 3043, 3063, 3092, 3677, 3807, 3945], 'able': [531, 1286], '6-month': [536], 'treatment': [537, 546, 812, 1904, 1946, 2166, 2849, 3174, 3577, 3592], 'duration': [538], 'drug-susceptible': [540], 'also': [543, 1109, 1416, 1552, 4023], 'offer': [544], 'opportunities': [547], 'TB.': [550, 817], 'human': [551, 680], 'virus': [553], 'minimum': [556, 559], 'concentration': [558, 561, 564, 1771, 1890, 1928, 3408, 3669, 4207], 'Wayne': [562, 1766, 1938, 2076, 2439, 2479, 2612, 2863, 3050, 3415, 3528, 3695, 3916, 4220, 4269], 'colony-forming': [565, 1906], 'unit': [566, 908, 1907], 'N,N′-dicyclohexylcarbodiimide': [567], 'diethylenetriamine/nitric': [568], 'Tubercle': [570], 'enter': [572], 'lungs': [573, 1561], 'healthy': [575], 'individuals': [576], 'inhalation,': [578], 'where': [579, 1471, 1891, 1929], 'they': [580], 'phagocytosed': [582], 'alveolar': [585], 'macrophages': [586], 'eliminate': [588], 'most': [589], 'invading': [592], '(3Koul': [594], 'A.': [595, 601, 836, 1065, 1160, 2386, 2490], 'Herget': [596], 'T.': [597, 936, 1205], 'Klebl': [598], 'B.': [599, 842, 1089, 1184, 2392, 2496], 'Ullrich': [600], 'Nat.': [602, 859, 1540, 2409, 2513], 'Rev.': [603, 991], 'Microbiol.': [604, 715, 992], '2004;': [605, 646, 1219, 2244], '2:': [606], '189-202Crossref': [607], '(312)': [610], 'However,': [613, 2954, 3225, 3331, 3639, 3978], 'small': [615], 'proportion': [616], 'survive': [619], 'exist': [621], 'hypometabolic': [625], 'state,': [626], 'these': [628, 658, 3211, 4236, 4285], 'killing': [633, 2875, 2995, 3492, 3521, 3615, 3655, 3661, 3687, 3703, 3732, 3974, 4102, 4255, 4310], 'anti-TB': [636, 1570], 'isoniazid': [640, 2451, 2914, 3204, 3526, 3631, 3643], '(4Gomez': [641], 'J.E.': [642], 'McKinney': [643], 'J.D.': [644, 1810], 'Tuberculosis.': [645], '84:': [647, 2245], '29-44Crossref': [648], '(441)': [651], 'They': [654], 'can': [655, 961, 1270, 2878, 3062, 3944], 'linger': [656], 'altered': [659], 'physiological': [660, 3351, 4095, 4341], 'environments': [661], "individual's": [664], 'lifetime': [665], 'maintain': [667], 'capability': [669], 'after': [674, 1900, 1942, 2102, 3173], 'reactivation.': [675], 'pathophysiological': [677], 'conditions': [678, 1685, 2441, 2480, 2550, 3069, 4093], 'lesions,': [681], 'thought': [682], 'lead': [684, 798, 2724, 4350], 'persistence,': [686], 'reduced': [688, 1306, 3020, 3222], 'oxygen': [689, 1956, 2117, 3116], 'tension,': [690], 'nutrient': [691], 'limitation,': [692], 'acidic': [694], 'pH': [695], '(5Flynn': [696], 'J.L.': [697], 'Chan': [698], 'Infect.': [700, 716, 2093], 'Immun.': [701, 2094], '2001;': [702, 940, 2630], '69:': [703], '4195-4201Crossref': [704], '(347)': [707], 'Scholar,': [709, 926, 1073, 1168, 1201, 1537], '6Wayne': [710], 'L.G.': [711, 2090, 2092], 'Eur.': [712], 'Clin': [714], 'Dis.': [717], '1994;': [718], '13:': [719], '908-914Crossref': [720], '(322)': [723], 'Recently,': [726], 'chemical': [731, 1351, 3779, 3849], 'class,': [732], '(DARQs)': [734], 'demonstrate': [736, 1417, 4308], 'potent': [737, 1358, 3046, 3431], 'anti-mycobacterial': [738], 'both': [743, 1134, 3429, 3539, 3996, 4027], 'vitro': [745, 1136, 2740, 3890], 'vivo': [748, 1139], '(7Andries': [749, 1491, 1708, 1837, 2781, 4157], 'K.': [750, 840, 858, 989, 1492, 1709, 1838, 2390, 2408, 2494, 2512, 2782, 3825, 4158], 'Verhasselt': [751, 1493, 1710, 1839, 2783, 4159], 'Guillemont': [753, 853, 1495, 1712, 1841, 2403, 2507, 2785, 4161], 'Gohlmann': [755, 1497, 1714, 1843, 2787, 4163], 'H.W.': [756, 1498, 1715, 1844, 2788, 4164], 'Neefs': [757, 1499, 1716, 1845, 2789, 4165], 'J.M.': [758, 1500, 1717, 1846, 2790, 4166], 'Winkler': [759, 1501, 1718, 1847, 2791, 4167], 'H.': [760, 850, 930, 1502, 1719, 1848, 2400, 2504, 2792, 4168], 'Van': [761, 1503, 1720, 1849, 2793, 4169], 'Gestel': [762, 1504, 1721, 1850, 2794, 4170], 'Timmerman': [764, 1506, 1723, 1852, 2796, 4172], 'Zhu': [766, 1508, 1725, 1854, 2798, 4174], 'Lee': [768, 1510, 1727, 1856, 2800, 4176], 'E.': [769, 776, 780, 1511, 1518, 1522, 1728, 1735, 1739, 1857, 1864, 1868, 2801, 2808, 2812, 4177, 4184, 4188], 'de': [772, 1514, 1731, 1860, 2804, 4180], 'Chaffoy': [773, 1515, 1732, 1861, 2805, 4181], 'Huitric': [775, 1517, 1734, 1863, 2807, 4183], 'Hoffner': [777, 1519, 1736, 1865, 2809, 4185], 'Cambau': [779, 1521, 1738, 1867, 2811, 4187], 'Truffot-Pernot': [781, 1523, 1740, 1869, 2813, 4189], 'Lounis': [783, 1525, 1742, 1871, 2815, 4191], 'Jarlier': [785, 1527, 1744, 1873, 2817, 4193], 'Science.': [787, 918, 1529, 1746, 1875, 2819, 4195], '2005;': [788, 919, 1066, 1161, 1530, 1542, 1747, 1818, 1876, 2820, 4196], '307:': [789, 1531, 1748, 1877, 2821, 4197], '223-227Crossref': [790, 1532, 1749, 1878, 2822, 4198], '(1813)': [793, 1535, 1752, 1881, 2825, 4201], 'Scholar),': [795], 'compound,': [799, 2725], '(or': [801], 'TMC207),': [802], 'currently': [804], 'Phase': [806], 'IIb': [807], 'clinical': [808], 'trials': [809], 'acts': [819], 'specifically': [821, 1441], 'targeting': [822, 1362], 'membrane-bound': [824], 'c-subunit': [825, 2775, 4153], 'F1F0-ATP': [827], 'synthase,': [828, 1120], 'ATP-synthesizing': [830], 'machinery': [831], 'cell': [834, 2535, 2659, 2921], '(8Koul': [835, 2385, 2489], 'Dendouga': [837, 2387, 2491], 'Vergauwen': [839, 2389, 2493], 'Molenberghs': [841, 2391, 2495], 'Vranckx': [843, 2393, 2497], 'L.': [844, 1046, 1141, 2394, 2498], 'Willebrords': [845, 2395, 2499], 'R.': [846, 2396, 2500], 'Ristic': [847, 2397, 2501], 'Z.': [848, 2398, 2502], 'Lill': [849, 2399, 2503], 'Dorange': [851, 2401, 2505], 'I.': [852, 2402, 2506], 'Bald': [855, 2405, 2509], 'Andries': [857, 2407, 2511], 'Chem.': [860, 939, 2410, 2514], 'Biol.': [861, 938, 2411, 2515], '2007;': [862, 2412, 2516], '3:': [863, 2413, 2517], '323-324Crossref': [864, 2414, 2518], '(453)': [867, 2417, 2521], 'During': [870, 3785], 'synthesis': [871, 1251, 2472, 2559], 'ATP,': [873, 1332], 'energy': [875, 1335, 1581, 3793], 'stored': [876], 'electrochemical': [879], 'proton': [880], 'gradient': [881], 'across': [882], 'membrane': [884, 1008, 1256, 1387, 1404, 2526, 2540], 'utilized': [886, 1273], 'drive': [888], 'protons': [889, 978], 'periplasmic': [892, 984], 'space': [893, 985], 'into': [894, 912, 982], 'cytoplasm': [896, 981], 'through': [897, 971, 2654], 'F0': [899], 'subunit': [900], 'supplying': [902], 'torque': [904], 'F1': [907], 'convert': [910], 'ADP': [911, 970], '(9Junge': [914], 'W.': [915], 'Nelson': [916], '308:': [920], '642-644Crossref': [921], '(53)': [924], '10Bald': [927], 'Noji': [929], 'Yoshida': [931], 'Hirono-Hara': [933], 'Y.': [934, 1081, 1176, 2008, 3823], 'Hisabori': [935], '276:': [941], '39505-39507Abstract': [942], 'Full': [943, 945], 'Text': [944, 946], 'PDF': [947], '(62)': [950], 'Under': [953], 'nonrespiratory': [954], 'conditions,': [955, 2751, 4237], 'several': [957, 1778, 2168, 3103, 4346], 'bacteria,': [958], 'synthases': [960], 'function': [962], 'reverse': [965], 'direction,': [966], 'hydrolyzing': [967], 'ATPase': [972], 'pumping': [977], '(11Deckers-Hebestreit': [986], 'G.': [987, 1087, 1182, 1207], 'Altendorf': [988], 'Annu.': [990], '1996;': [993, 2095], '50:': [994], '791-824Crossref': [995], '(175)': [998], 'way,': [1003], 'generates': [1006], 'required': [1010], 'uptake': [1013], 'nutrients.': [1015], 'considerable': [1020], 'remodeling': [1021], 'respiratory': [1024], 'chain': [1025, 4010], 'has': [1026, 2956, 3095, 3278], 'reported,': [1028], 'including': [1029], 'cytochrome': [1032, 1040], 'aa3': [1033], 'type': [1034, 1042, 2830], 'oxidase': [1035, 1044], 'up-regulation': [1037], 'bd': [1041], 'menaquinole': [1043], '(12Shi': [1045, 1140], 'Sohaskey': [1047, 1142], 'C.D.': [1048, 1143], 'Kana': [1049, 1144], 'B.D.': [1050, 1145], 'Dawes': [1051, 1146], 'North': [1053, 1148], 'R.J.': [1054, 1149], 'Mizrahi': [1055, 1150], 'Gennaro': [1057, 1152], 'M.L.': [1058, 1153], 'Proc.': [1059, 1154], 'Natl.': [1060, 1155], 'Acad.': [1061, 1156], 'Sci.': [1062, 1157], 'U.': [1063, 1158], '102:': [1067, 1162], '15629-15634Crossref': [1068, 1163], '(254)': [1071, 1166], '13Schnappinger': [1074, 1169], 'Ehrt': [1076, 1171], 'Voskuil': [1078, 1173], 'M.I.': [1079, 1174, 2177, 2183, 2237, 3119, 3125, 3307, 3313], 'Liu': [1080, 1175], 'Mangan': [1082, 1177], 'J.A.': [1083, 1178, 2006], 'Monahan': [1084, 1179], 'I.M.': [1085, 1180, 1814, 2976], 'Dolganov': [1086, 1181, 2184, 3126, 3314], 'Efron': [1088, 1183], 'Butcher': [1090, 1185], 'P.D.': [1091, 1186], 'Nathan': [1092, 1187], 'Schoolnik': [1094, 1189, 2188, 2240, 3130, 3318], 'G.K.': [1095, 1190, 2189, 2241, 3131, 3319], 'Exp.': [1097, 1192, 1217, 2191, 3133, 3321], '198:': [1100, 1195, 2194, 3136, 3324], '693-704Crossref': [1101, 1196], '(1169)': [1104, 1199], 'Several': [1107], 'studies': [1108, 1796], 'suggest': [1110, 4042], 'hypometabolic,': [1112], 'nonreplicating': [1113, 1313, 1339, 2731, 4245], 'decreased': [1116, 4024], 'requirements': [1117], 'since': [1121, 3673], 'genes': [1123, 2304], 'encoding': [1124], 'components': [1126], 'down-regulated,': [1133], '14Karakousis': [1202], 'P.C.': [1203], 'Yoshimatsu': [1204], 'Lamichhane': [1206], 'Woolwine': [1208], 'S.C.': [1209], 'Nuermberger': [1210], 'Grosset': [1212], 'Bishai': [1214], 'W.R.': [1215, 2016], '200:': [1220], '647-657Crossref': [1221], '(205)': [1224], 'It': [1227, 3277], 'is,': [1228], 'however,': [1229], 'open': [1231], 'question': [1232], 'whether': [1233, 1244, 1282], 'plays': [1236], 'essential': [1238, 1592], 'role': [1239], 'enzyme': [1246, 1269], 'responsible': [1248], 'and/or': [1252], 'maintenance': [1253], 'potential.': [1257], 'Furthermore,': [1258, 3203], 'not': [1261, 1399, 2911, 3238, 3252, 3895], 'known': [1262], 'whether,': [1263], 'despite': [1264, 1296, 1574], 'down-regulation,': [1267], 'still': [1271, 1285], 'DARQs': [1283, 1310, 3774, 4100, 4314], 'kill': [1289, 1312], 'Here': [1292], 'report': [1294], 'that,': [1295], 'substantial': [1298], 'find': [1317], 'functional': [1324], 'capable': [1329], 'synthesizing': [1331], 'scarce': [1334], 'resource': [1336], 'cell.': [1340], 'depletion': [1342, 1957, 2080, 2846, 3014, 3117, 3234], 'R207910-mediated': [1350, 3660], 'inhibition': [1352], 'leads': [1356, 2888, 3863], 'Thus,': [1361], 'processes': [1363], 'generate': [1365], 'concurrently': [1368], 'disturb': [1369], 'homeostasis': [1373], 'effective': [1376, 1481, 2949], 'strategy': [1377], 'dormancy.': [1379, 1446], 'exhibits': [1381], 'no': [1382, 2897, 3032, 3191, 3208, 3269, 3633, 3653, 3674, 3714, 4213, 4233], 'significant': [1383], 'effect': [1384, 2721, 2899, 2996, 3034, 3192, 3209, 3271, 3634, 3858, 3914, 4056, 4214, 4234, 4256], 'suggesting': [1394, 4238], 'critical': [1400, 1601, 4327], 'maintaining': [1402], 'but': [1406, 3030, 3378, 3611], 'primarily': [1408], 'production': [1412, 1587, 3796], 'ATP.': [1414], 'increased': [1419], 'susceptibility': [1420], 'toward': [1424], 'compared': [1427, 2939, 3197, 3457, 3482, 3935], 'actively': [1429, 1459, 3401, 3484, 3502, 3747, 3880], 'growing': [1430, 3485], 'bacteria.': [1431], 'Using': [1432], 'R207910-resistant': [1433, 2760], 'mycobacterial': [1434, 1594, 1607, 1961, 2084, 2303, 3022, 3194, 4091], 'strains,': [1435], 'targets': [1442, 3819], 'during': [1445, 1583, 2424, 2749, 3648, 3656, 4133], 'action': [1451, 4098], 'bacteria': [1461, 1897, 1934, 3299, 3470, 3675, 3787, 3971], 'probably': [1462], 'contributes': [1463], 'its': [1465, 2874, 3854, 3966, 4299], 'efficacy': [1468, 2755, 3385, 4138], 'mice,': [1470], 'monotherapy': [1475], 'was': [1476, 1675, 1781, 1886, 1924, 1963, 2146, 2231, 2264, 2317, 2342, 2484, 2561, 2602, 2648, 2680, 2734, 2900, 2910, 3220, 3237, 3272, 3445, 3616, 3670, 3775], 'shown': [1477, 2958, 3097, 3281], 'triple': [1484], 'combination': [1485], 'rifampin,': [1487], 'isoniazid,': [1488, 3424, 3498], 'pyrazinamide': [1490], '15Mitchison': [1538], 'D.A.': [1539], 'Biotechnol.': [1541], '23:': [1543], '187-188Crossref': [1544], '(21)': [1547], 'may': [1551], 'explain': [1553], 'ability': [1555], 'render': [1560], 'mice': [1564], 'culture-negative': [1565], 'faster': [1566], 'first': [1568, 3364, 3574, 3609, 3650, 3958], 'line': [1569, 3365, 3368], 'drugs.': [1571, 3187], 'conclusion,': [1573], 'number': [1576], 'changes': [1578, 3780, 3850, 4344], 'metabolism': [1582], 'dormancy,': [1584, 3786, 4134], 'remains': [1591], 'survival.': [1595], 'study': [1598, 2308], 'demonstrates': [1599], 'importance': [1602], 'dormancy': [1608, 2082, 2105, 2145, 2425, 2440, 2741, 2837, 3110, 3162, 3235, 4340], 'suggests': [1610, 3467, 4288], 'excellent': [1617], 'treat': [1620], 'Bacterial': [1624], 'Strains': [1625], 'Culture': [1627, 1644], 'Medium—M.': [1628], 'H37Rv,': [1630], 'smegmatis,': [1632, 2617], 'bovis': [1635], 'BCG': [1636], 'were': [1637, 1647, 1898, 1940, 2034, 2062, 2118, 2136, 2213, 2371, 2422, 2445, 2465, 2528, 2542, 2640, 2652, 2661, 2697, 2708, 2834, 3009, 3178, 3346, 3428, 3541, 3875, 3908, 4241], 'obtained': [1638, 2147], 'American': [1641], 'Type': [1642], 'Tissue': [1643], 'collection.': [1645], 'Mycobacteria': [1646, 3360], 'cultured': [1648], 'Middlebrook': [1650], '7H9': [1651, 1785, 2043], 'medium': [1652, 2044], '(Difco)': [1653], '0.05%': [1655], 'Tween-80': [1656], '(Sigma)': [1657], 'log': [1659, 2362], 'phase': [1660, 2363, 4342], 'period': [1663, 2127, 3291], '3–4': [1665], 'days': [1666, 1902, 1944, 2028, 2108, 2444, 2483, 2869], 'before': [1667], 'start': [1669], 'experiment.': [1672], 'incubation': [1674], 'done': [1676], '250-ml': [1679], 'sterile': [1680], 'Duran': [1681], 'bottle': [1682], 'stirring': [1684, 2549], '37': [1686], '°C': [1687], '(500': [1688], 'rpm).': [1689], 'Chemical': [1690], 'Synthesis': [1691, 2470, 4336], 'DARQ': [1693, 1779, 2723, 3767, 3783, 3873, 4051, 4075, 4322], 'Analogs—DARQ': [1694], 'compounds': [1695, 1780, 2169, 3496, 3898, 4287], 'synthesized': [1697], 'described': [1699, 1793, 1989, 2088, 2175, 2235, 2282, 2331, 2384, 2487, 2620], 'earlier': [1702, 1795], 'patent': [1703], '(WO2004/011436)': [1704], 'previous': [1706], 'reports': [1707], 'MIC': [1755, 3891], 'Microdilution': [1756], 'Assays': [1757], 'Determination': [1759], 'Minimum': [1761], 'Bactericidal': [1762, 2713], 'Concentration': [1763, 1768], '(MBC90)': [1764, 3413], 'Cidal': [1767], '(WCC90)—Minimum': [1769], '(MIC,': [1772], 'μg/ml)': [1773, 2458, 3206, 3259, 4000, 4031], 'determined': [1782, 1887, 1925, 2063, 2562, 3405], 'using': [1784, 1829, 1910, 1950, 2273, 2320, 2373, 2530, 2576, 2604, 2699, 2838], 'liquid': [1786, 2670], 'broth': [1787], '7H10': [1789, 1911, 1951, 2067, 2139], 'agar': [1790, 1912, 1952, 2068], 'dilution': [1791, 1913], '(16Lenaerts': [1797], 'A.J.': [1798], 'Gruppo': [1799], 'Marietta': [1801], 'K.S.': [1802], 'Johnson': [1803], 'C.M.': [1804], 'Driscoll': [1805], 'D.K.': [1806], 'Tompkins': [1807], 'N.M.': [1808], 'Rose': [1809], 'Reynolds': [1811], 'R.C.': [1812], 'Orme': [1813, 2975], 'Antimicrob.': [1815, 2977], 'Agents': [1816, 2978], 'Chemother.': [1817, 2979], '49:': [1819], '2294-2301Crossref': [1820], '(289)': [1823], 'Scholar)': [1825, 2251], 'minor': [1827], 'modifications': [1828], 'Alamar': [1830], 'blue': [1831], 'resazurin': [1833], 'fluorometric': [1835], 'measurement': [1836], 'MBC90': [1884], '(μg/ml)': [1885, 1923], '90%': [1892, 1930], 'aerobic': [1895, 2364, 2610, 3100, 3412, 3559, 3641, 3997, 4028, 4103], 'killed': [1899, 1941, 3644], '5': [1901, 1943], '(CFU)': [1908], 'counting': [1909, 1949], 'according': [1914, 2682], 'Clinical': [1916], 'Laboratory': [1918], 'Standards': [1919], 'Institute': [1920], 'guidelines.': [1921], 'WCC90': [1922], '(grown': [1935], 'model)': [1939, 1959, 2427], 'CFU': [1948, 2894, 3056, 3266, 3931, 4005, 4038], 'dilution.': [1953], 'Dormancy': [1954], 'Assays—Drastic': [1955], '(hypoxia': [1958], 'cultures': [1962, 2033, 2061, 2113, 2150, 2367, 3008, 3148, 3540, 3887, 3940], 'achieved': [1964], 'placing': [1966], 'loosely': [1967], 'capped': [1968], 'tubes': [1969, 3288], 'containing': [1970], 'different': [1971, 2738, 3762], 'inside': [1974], 'anaerobic': [1976, 1981, 2952, 3017, 3073], 'jar': [1977], '(BBL)': [1978], 'along': [1979], 'gas': [1982], 'generation': [1983], 'envelopes': [1984], '(using': [1985], 'palladium': [1986], 'catalysts),': [1987], 'previously': [1990, 2087, 2174, 2234, 2383, 2488, 2619, 3280], '(17Stover': [1991], 'C.K.': [1992], 'Warrener': [1993], 'VanDevanter': [1995], 'D.R.': [1996, 1998, 2187, 3129, 3317], 'Sherman': [1997, 2186, 3128, 3316], 'Arain': [1999], 'T.M.': [2000], 'Langhorne': [2001], 'M.H.': [2002], 'Anderson': [2003], 'S.W.': [2004], 'Towell': [2005], 'Yuan': [2007], 'McMurray': [2009], 'D.N.': [2010], 'Kreiswirth': [2011], 'B.N.': [2012], 'Barry': [2013], 'C.E.': [2014], 'Baker': [2015], 'Nature.': [2017], '2000;': [2018], '405:': [2019], '962-966Crossref': [2020], '(921)': [2023], 'After': [2026], '7': [2027, 2868], 'anaerobiosis,': [2030], 'harvested': [2035], 'low': [2037, 3153], 'speed': [2038], 'centrifugation,': [2039], 'washed': [2040], 'twice': [2041], 'remove': [2046], 'resuspended': [2050, 2214], 'drug-free': [2052], 'medium.': [2053], 'CFUs': [2055, 2135, 2937, 3026, 3568, 3586, 3603, 3625, 3709, 4267], 'treated': [2058, 2119, 2446, 2862, 3553], 'untreated': [2060, 2941, 3199, 3627, 3937], 'plating': [2065], 'evaluate': [2070, 3392, 3516], 'model,': [2077, 2144, 3005, 3051], 'gradual': [2078, 2110, 2840], 'O2': [2079, 2111, 2845, 3013, 3233], 'induces': [2081, 3108], 'cultures,': [2085, 3560, 3642], '(18Wayne': [2089], 'Hayes': [2091], '64:': [2096], '2062-2069Crossref': [2097], 'Briefly,': [2101, 2524, 2638], 'induction': [2103], '18': [2107, 2443], 'depletion,': [2112], 'without': [2114], 'exposure': [2115], 'various': [2122, 3846], 'ranging': [2128], '4': [2130, 2460], '21': [2132, 3719], 'days,': [2133, 2461], 'counted': [2137, 2667, 3678], 'plates.': [2140], 'NO': [2143, 2156, 2848, 3094, 3255, 3283, 4227, 4276], 'incubating': [2149], '150': [2152], 'μm': [2153], 'donor': [2157], '(diethylenetriamine/nitric': [2158], 'oxide': [2159], '(DETA/NO))': [2160], 'h,': [2163, 3297], 'followed': [2164, 2423], '10': [2171, 2482, 2555, 2856, 2886, 3028, 3181, 3667, 3924, 4209], 'h': [2172, 3172, 3182, 3343], '(19Voskuil': [2176, 3118, 3306], 'Schnappinger': [2178, 3120, 3308], 'Visconti': [2180, 2238, 3122, 3310], 'K.C.': [2181, 2239, 3123, 3311], 'Harrell': [2182, 3124, 3312], 'G.M.': [2185, 2628, 3127, 3315], '705-713Crossref': [2195, 3137, 3325], '(783)': [2198, 3140, 3328], 'RNA': [2201, 2230, 2272, 2341], 'Isolation': [2202], 'Real': [2204, 2313], 'Time': [2205], 'Quantitative': [2206], 'PCR—Dormant': [2207], 'pellets': [2212], 'Trizol': [2216], 'disrupted': [2218], 'acid-washed': [2220], 'glass': [2221], 'beads': [2222], 'Mixer': [2225], 'Mill': [2226], '(MM': [2227], '301).': [2228], 'Total': [2229, 2355], 'isolated': [2232], '(20Voskuil': [2236], 'Tuberculosis': [2242], '(Edinb.).': [2243], '218-227Crossref': [2246], '(353)': [2249], 'cleaned': [2253], 'up': [2254], 'RNeasy': [2257], 'Protect': [2258], 'Bacteria': [2259], 'minikit': [2260], '(QIAgen).': [2261], 'Reverse': [2262], 'transcription': [2263], 'carried': [2265, 2318], 'out': [2266, 2319], '0.5': [2268], 'μg': [2269], 'total': [2271], 'random': [2274], 'hexamer': [2275], 'primers': [2276, 2300], 'Superscript': [2278], 'II': [2279], 'RT': [2280], 'manufacturer': [2285], '(Invitrogen).': [2286], 'sequence': [2288, 2325], 'TaqMan': [2291], 'FAM': [2292], '(6-carboxyfluorescein)': [2293], 'TAMRA': [2295], '(6-carboxy-N,N,N′,N′-tetramethylrhodamine)': [2296], 'probes': [2297], '(Eurogentec)': [2298], 'analyzed': [2305], 'available': [2310], 'upon': [2311], 'request.': [2312], 'time': [2314], 'quantitative': [2315], 'PCR': [2316], 'ABI': [2322], 'PRISM': [2323], '7900HT': [2324], 'detection': [2326], 'system': [2327, 2579], '(Applied': [2328], 'Biosystems)': [2329], 'manufacturer.': [2334], 'Amplification': [2335], 'endogenous': [2337], '16': [2338, 3296], 'S': [2339], 'ribosomal': [2340], 'performed': [2343, 2698], 'standardize': [2345], 'amount': [2347, 2572], 'cDNA': [2349], 'sample': [2350], 'added': [2351], 'each': [2353], 'reaction.': [2354], 'Cellular': [2356], 'Measurement': [2358, 2467, 2596], 'Assay—ATP': [2359], 'measured': [2372, 2485, 2603, 3520], 'bioluminescence': [2376], 'assay': [2377], 'kit': [2378], '(Roche': [2379], 'Applied': [2380, 2587], 'Science),': [2381], '(Wayne': [2426], 'day': [2429, 2432, 3588, 3613, 3680, 3711, 3718], '0': [2430], '21.': [2433], 'Additionally,': [2434], 'cultivated': [2437], 'under': [2438, 2478, 2548, 2951, 4235], '(0.006–6': [2449], 'μg/ml),': [2450, 2453, 3228, 3455], '(0.3': [2452], 'dicyclohexylcarbodiimide': [2455], '(DCCD)': [2456], '(100': [2457, 3227], 'measured.': [2466], 'Activity—ATP': [2471], 'smegmatis': [2476], 'inverted': [2525], 'vesicles': [2527, 2541], 'prepared': [2529, 3876], 'precooled': [2532], 'French': [2533], 'pressure': [2534], 'at': [2536, 2551, 2885, 2902, 2928, 2997, 3027, 3035, 3058, 3274, 3665, 3691, 3742, 3921, 3975], '20,000': [2537], 'p.s.i.': [2538], 'preincubated': [2543], 'DCCD': [2547, 4251, 4291], 'room': [2552], 'temperature': [2553], 'min.': [2556], 'energizing': [2564], 'membranes': [2566], 'NADH': [2568], 'quantifying': [2570], 'produced': [2575], 'luciferin/luciferase': [2578], '(ATP': [2580], 'Bioluminescence': [2581], 'Assay': [2582], 'Kit': [2583], 'HS': [2584], 'II;': [2585], 'Roche': [2586], 'Science).': [2588], 'Data': [2589], 'presented': [2591], 'averages': [2593, 2689], '±': [2594, 2690], 'S.E.': [2595, 2691], 'Membrane': [2599, 2676], 'Potential—Membrane': [2600], 'tetra-[3H]phenylphosphonium': [2605, 2646], 'bromide': [2606, 2647], '(Amersham': [2607], 'Biosciences)': [2608], '(10': [2614, 3205, 3258, 3342, 3556], 'days)': [2615], '(21Rao': [2621], 'Streur': [2623], 'T.L.': [2624], 'Aldwell': [2625], 'F.E.': [2626], 'Cook': [2627], 'Microbiology.': [2629], '147:': [2631], '1017-1024Crossref': [2632], '(111)': [2635], 'cells': [2639, 2651], 'energized': [2641], '20': [2643, 3906], 'mm': [2644], 'glucose,': [2645], 'added,': [2649], 'centrifuged': [2653], 'silicon': [2655], 'oil.': [2656], 'Supernatant': [2657], 'pellet': [2660], 'dissolved': [2662], 'scintillation': [2664, 2671], 'fluid': [2665], 'analyzer': [2672], '(TRI-CARB': [2673], '2100TR;': [2674], 'Packard).': [2675], '(in': [2678], 'mV)': [2679], 'calculated': [2681], 'Nernst': [2685], 'relationship.': [2686, 3870], 'Values': [2687], 'represent': [2688], 'four': [2693], 'independent': [2694], 'experiments.': [2695], 'Comparisons': [2696], "Student's": [2700], 't': [2701], 'test': [2702], '(StatXact).': [2703], 'p': [2704], 'values': [2705, 3546], '<0.05': [2707], 'considered': [2709], 'statistically': [2711], 'significant.': [2712], 'Activity': [2714, 3768], 'Dormant': [2718, 3356, 3770], 'tuberculosis—The': [2720], 'growth': [2729, 4092], 'tested': [2735, 2753, 3878, 4136], 'three': [2737], 'models.': [2742], 'As': [2743, 2877, 3629, 3943], 'specificity': [2748, 3772, 4130], 'strain': [2761, 4144, 4218], '(BK12),': [2765], 'carrying': [2766], 'point': [2768], 'mutation': [2769, 4151], 'α-helix': [2772], 'complex': [2780], 'Both': [2828], 'wild': [2829], 'mutant': [2832, 4217], 'subjected': [2835, 3010], 'either': [2839], '(Wayne)': [2841], 'drastic': [2843, 2994, 3012, 4254], '(hypoxia)': [2844], 'presence': [2852], '0.1': [2854, 2903, 3036, 3275], 'μg/ml': [2857, 2887, 2930, 2999, 3029, 3037, 3668, 3693, 3907, 3925], '(Fig.': [2859, 3000, 3038, 3166, 3201, 3534, 3682, 3720, 3899, 4065, 4221, 4224, 4228, 4270, 4273, 4277], '1).': [2860, 3421], 'determine': [2873], 'efficacy.': [2876], 'seen': [2880, 3946], 'Fig.': [2882], '1A,': [2883], '1.8-log10': [2891, 3600], 'reduction': [2892, 2935, 3057, 3584, 3716, 4111], 'counts,': [2895, 3267], 'whereas': [2896, 3214, 3268], 'apparent': [2898, 3033, 3270], 'observed': [2901, 3273, 3562], 'μg/ml.': [2904, 3060, 3276, 3977], 'viability': [2906, 3023, 3216], 'affected': [2912], 'treatment,': [2915], 'biosynthesis': [2919], 'wall': [2922], 'mycolic': [2923], 'acids.': [2924], 'contrast,': [2926, 3443, 3591, 3685], 'metronidazole': [2927, 3226], '100': [2929, 2998, 3059], 'led': [2931, 3260, 3926, 3988, 4258], '1.9-log10': [2934], 'control.': [2942, 3628], 'Metronidazole': [2943, 3040], 'prodrug': [2946], 'only': [2950, 3247, 3754], 'conditions.': [2953, 4230], 'ineffective': [2961], 'Cornell': [2967], 'mouse': [2968], 'model': [2970, 3341], '(22Brooks': [2971], 'J.V.': [2972], 'Furney': [2973], 'S.K.': [2974], '43:': [2981], '1285-1288Crossref': [2982], 'DCCD,': [2986], 'nonspecific': [2988], 'inhibitor,': [2991], 'showed': [2992], '1A).': [3001], 'hypoxia': [3004, 4223, 4272], 'chamber.': [3018], '2.1-log10': [3025, 3930], 'had': [3031, 3190, 3207, 3632, 4212, 4232, 4252], '1B).': [3039], 'tends': [3041], 'slightly': [3044, 3446, 3472], '2.5-log10': [3055], 'explained': [3064], 'extreme': [3067], 'hypoxic': [3068], 'created': [3070], 'chamber,': [3074], 'such,': [3077, 3803], 'effects': [3079, 3333, 4085], 'metronidazole,': [3081], 'which': [3082], 'works': [3083], 'best': [3084], 'severely': [3087], 'O2-depleted': [3088], 'environment,': [3089], 'tend': [3090, 3300], 'enhanced.': [3093], 'inhibit': [3099], 'respiration': [3101], 'systems,': [3105], 'response': [3111], 'similar': [3114], 'Treatment': [3143], 'midlog': [3145], 'nontoxic': [3154], '(150': [3156], 'μm)': [3157], 'DETA/NO': [3159, 3188], 'induced': [3160], 'typical': [3161], 'regulon': [3163], 'gene': [3164], 'expression': [3165], '3A).': [3167], 'our': [3169, 4306], 'DETA/NO,': [3176], 'exposed': [3179], 'alone': [3189], '1C).': [3202], 'bacilli,': [3213], 'drastically': [3221], 'DCCD.': [3224], 'contrast': [3230], 'assays,': [3236], 'bactericidal,': [3239], 'because': [3240], 'prodrug,': [3243], 'O2-limiting': [3250], 'environment.': [3256], '1-log10': [3263], 'drop': [3264, 3566, 3601, 3623, 3707, 4265], 'dissipates': [3284], 'reaction': [3287], 'over': [3289], 'time,': [3293], 'lose': [3302], 'their': [3303, 3857, 3912, 4058, 4084], 'phenotype': [3305], 'NO-treated': [3337], 'treatment)': [3345], 'reached': [3347], 'within': [3348], 'phase.': [3352], 'Susceptibility': [3353], 'Comparison': [3354], 'Aerobically': [3358], 'Grown': [3359], 'R207910—The': [3362], 'second': [3367, 3658, 4124], 'antibiotics': [3370], 'exhibit': [3371], 'strong': [3372, 4044], 'none': [3379], 'comparable': [3384], 'order': [3390], 'versus': [3400, 3626, 3856], '(WCC90)': [3417], '(Table': [3420, 3941], 'Rifampicin': [3422], 'included': [3425], 'controls,': [3427], 'less': [3437], '(WCC90': [3452], '1': [3454, 3692, 3922, 3976], '(MBC90': [3462], 'μg/ml).': [3465, 3557], 'prone': [3474], '(about': [3475], '2-fold)': [3476], '(WCC90/MBC90': [3487], 'ratio': [3488], '0.5).TABLE': [3490], '1Comparative': [3491], '(rifampicin,': [3497], 'R207910)': [3500], 'tuberculosisCompoundMBC90WCC90WCC90/MBC90μg/mlμg/mlRifampicin0.030.517Isoniazid0.25>64>256R207910210.5': [3507], 'Open': [3508, 4116], 'table': [3509, 4117], 'tab': [3513, 4121], 'To': [3514], 'result,': [3518], 'kinetics': [3522, 3688], '2).': [3535, 3683, 3942], 'purpose,': [3538], 'diluted': [3542], 'equal': [3544, 3758], 'A600': [3545], '∼107': [3548], '108': [3550], 'CFU/ml': [3551], 'initial': [3564, 3599], '2.2-log10': [3565], 'end': [3571, 3606], 'week': [3575], 'additional': [3582, 3621, 3654], '0.8-log10': [3583], '14.': [3589], 'resulted': [3596], 'week,': [3610, 3651], '14,': [3614], 'pronounced,': [3618], '3.0-log10': [3622], 'expected,': [3630], 'cultures.': [3638], 'about': [3645], '2.2': [3646], 'log10': [3647], 'week.': [3659], 'highly': [3671, 4087], 'potent,': [3672], 'could': [3676], '14': [3681, 3712], 'suggested': [3699], 'characteristic': [3701], 'biphasic': [3702], '2.9-log10': [3706], 'S1).': [3721], 'summary,': [3723, 4305], 'measuring': [3725], 'kinetics,': [3733], 'demonstrated': [3735], 'least': [3743], 'makes': [3751], 'activities': [3760, 4059, 4073], 'subpopulations.': [3764], 'Specificity': [3765], 'Mycobacteria—Target': [3771], 'assessed': [3776], 'introducing': [3778], 'scaffold.': [3784], 'might': [3788, 3806, 3815], 'alternative': [3790], 'means': [3791], '(e.g.': [3797], 'substrate': [3798], 'level': [3799], 'phosphorylation),': [3800], 'redundant.': [3808], 'Hence,': [3809], 'postulated': [3812], 'affect': [3816], 'other': [3817], '(23Zhang': [3822], 'Post-Martens': [3824], 'Denkin': [3826], 'Drug': [3828], 'Discov.': [3829], 'Today.': [3830], '2006;': [3831], '11:': [3832], '21-27Crossref': [3833], '(171)': [3836], 'At': [3839, 4204], 'first,': [3840], 'studied': [3842], 'correlation': [3844, 4045], 'between': [3845, 3903, 4014, 4046, 4070, 4284], 'structural': [3847, 4047], 'analogs': [3855, 4076], 'biological': [3860], 'determination': [3866, 3892], 'structure-activity': [3869], 'Over': [3871], '400': [3872], 'derivatives': [3874], 'assays': [3893], '(data': [3894], 'shown).': [3896], 'Five': [3897], 'S2A)': [3900], 'MICs': [3902], '0.09': [3904], 'selected': [3909], 'evaluating': [3911], '1.3-': [3928], 'reduction,': [3932], 'respectively,': [3933], 'Table': [3948], '2,': [3949], 'analogue': [3951], 'methyl': [3954], 'substituent': [3955], 'aryl': [3959], 'moiety': [3960], '(named': [3963], '18040971-AAA)': [3964], 'retained': [3965], '1.55-log10': [3973], 'replacement': [3979], 'dimethylamino': [3982, 4020], 'group': [3983, 4021], 'azole': [3985], 'groups': [3986], '(25756770-AAA)': [3987], 'decrease': [3991], '(MIC': [3998, 4029], '8.19': [3999], '(0.29-log10': [4004], 'reduction).': [4006, 4039], 'Interestingly,': [4007], 'changing': [4008], 'length': [4011], 'hydroxyl': [4016], 'terminal': [4019], '(18086601-AAA)': [4022], '20.21': [4030], '(0.11-log10': [4037], 'data': [4041], 'variations': [4048], 'scaffold': [4052], 'subsequent': [4055], 'S2B).': [4066], 'sharp': [4068], 'overlap': [4069], 'implies': [4082], 'target-specific,': [4088], 'irrespective': [4089], 'states.TABLE': [4096], '2Bactericidal': [4097], 'tuberculosisCompound': [4107], 'IDMIC90': [4108], '(aerobic': [4109], 'cultures)Log10': [4110], '(dormant': [4112], 'cultures)10': [4113], 'μg/ml1': [4114], 'μg/mlμg/mlR2079100.092.11.3518040971-AAA0.162.131.5517996134-AAA1.741.140.8725756770-AAA8.190.980.2918086601-AAA20.210.230.11': [4115], 'approach': [4125], 'characterize': [4127], 'resistant': [4143], '(BK12)': [4148], 'bearing': [4149], 'highest': [4206], 'μg/ml,': [4210], '1A),': [4222, 4271], '1B),': [4225, 4274], '1C)': [4229], 'Isoniazid': [4231], 'indeed': [4242], 'state.': [4246], '5.3-,': [4261], '2.8-,': [4262], '4.3-log10': [4264], '1C),': [4278], 'respectively.': [4279], 'lack': [4281], 'cross-resistance': [4283], 'two': [4286], 'although': [4290], 'binds': [4292], 'binding': [4300], 'pocket': [4301], 'different.': [4303], 'critically': [4315], 'depends': [4316], 'structure': [4319], 'compound': [4323], 'amino': [4328], 'acid': [4329], 'compositions': [4330], 'protein.': [4334], 'Nonreplicating': [4338], 'Mycobacteria—The': [4339], 'involves': [4343], 'metabolic': [4347], 'pathways': [4348], 'reprogramming': [4354], 'd': [4356]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2164282552', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 24}, {'year': 2019, 'cited_by_count': 25}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 21}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 23}], 'updated_date': '2024-12-29T20:49:01.201596', 'created_date': '2016-06-24'}