Publication Information

{'id': 'https://openalex.org/W2163933871', 'doi': 'https://doi.org/10.1080/10715769900300711', 'title': 'Protoporphyrin IX and oxidative stress', 'display_name': 'Protoporphyrin IX and oxidative stress', 'publication_year': 1999, 'publication_date': '1999-01-01', 'ids': {'openalex': 'https://openalex.org/W2163933871', 'doi': 'https://doi.org/10.1080/10715769900300711', 'mag': '2163933871', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10499772'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10715769900300711', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S23349031', 'display_name': 'Free Radical Research', 'issn_l': '1029-2470', 'issn': ['1029-2470', '1071-5762'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111723159', 'display_name': 'Susana G. Afonso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Susana Afonso', 'raw_affiliation_strings': ['Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - CONICET, School of Sciences, University of Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - CONICET, School of Sciences, University of Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018440376', 'display_name': 'Gabriela Vanore', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Gabriela Vanore', 'raw_affiliation_strings': ['Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - CONICET, School of Sciences, University of Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - CONICET, School of Sciences, University of Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010729044', 'display_name': 'Alcira Batlle', 'orcid': 'https://orcid.org/0000-0002-4894-8955'}, 'institutions': [{'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Alcira Batlle', 'raw_affiliation_strings': ['Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - CONICET, School of Sciences, University of Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - CONICET, School of Sciences, University of Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I24354313', 'https://openalex.org/I151201029']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.343, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 110, 'citation_normalized_percentile': {'value': 0.919583, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '31', 'issue': '3', 'first_page': '161', 'last_page': '170'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12068', 'display_name': 'Neonatal Health and Biochemistry', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glutathione-reductase', 'display_name': 'Glutathione reductase', 'score': 0.60086966}, {'id': 'https://openalex.org/keywords/tbars', 'display_name': 'TBARS', 'score': 0.5405736}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7707361}, {'id': 'https://openalex.org/C2778979269', 'wikidata': 'https://www.wikidata.org/wiki/Q106951292', 'display_name': 'Catalase', 'level': 3, 'score': 0.6671648}, {'id': 'https://openalex.org/C2780829032', 'wikidata': 'https://www.wikidata.org/wiki/Q898539', 'display_name': 'Lipid peroxidation', 'level': 3, 'score': 0.6638226}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.6575556}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.60741574}, {'id': 'https://openalex.org/C165069038', 'wikidata': 'https://www.wikidata.org/wiki/Q420930', 'display_name': 'Glutathione reductase', 'level': 5, 'score': 0.60086966}, {'id': 'https://openalex.org/C2778760513', 'wikidata': 'https://www.wikidata.org/wiki/Q24773045', 'display_name': 'Glutathione peroxidase', 'level': 4, 'score': 0.5428422}, {'id': 'https://openalex.org/C2777352226', 'wikidata': 'https://www.wikidata.org/wiki/Q7669516', 'display_name': 'TBARS', 'level': 4, 'score': 0.5405736}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.5165936}, {'id': 'https://openalex.org/C2779480358', 'wikidata': 'https://www.wikidata.org/wiki/Q422926', 'display_name': 'Porphyrin', 'level': 2, 'score': 0.5126673}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.47717515}, {'id': 'https://openalex.org/C2778417259', 'wikidata': 'https://www.wikidata.org/wiki/Q619815', 'display_name': 'Protoporphyrin', 'level': 3, 'score': 0.4525402}, {'id': 'https://openalex.org/C2780795997', 'wikidata': 'https://www.wikidata.org/wiki/Q413283', 'display_name': 'Superoxide', 'level': 3, 'score': 0.42757434}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37211943}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3645785}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2426123}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.10505557}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.08657116}], 'mesh': [{'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011524', 'descriptor_name': 'Protoporphyrins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000624', 'descriptor_name': '5-Aminolevulinate Synthetase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000624', 'descriptor_name': '5-Aminolevulinate Synthetase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000624', 'descriptor_name': '5-Aminolevulinate Synthetase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005979', 'descriptor_name': 'Glutathione Peroxidase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005979', 'descriptor_name': 'Glutathione Peroxidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005979', 'descriptor_name': 'Glutathione Peroxidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005980', 'descriptor_name': 'Glutathione Reductase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005980', 'descriptor_name': 'Glutathione Reductase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005980', 'descriptor_name': 'Glutathione Reductase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006418', 'descriptor_name': 'Heme', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006418', 'descriptor_name': 'Heme', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008815', 'descriptor_name': 'Mice, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016877', 'descriptor_name': 'Oxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016877', 'descriptor_name': 'Oxidants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016877', 'descriptor_name': 'Oxidants', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000623', 'descriptor_name': 'Porphobilinogen Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000623', 'descriptor_name': 'Porphobilinogen Synthase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000623', 'descriptor_name': 'Porphobilinogen Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011166', 'descriptor_name': 'Porphyrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011166', 'descriptor_name': 'Porphyrins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011524', 'descriptor_name': 'Protoporphyrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011524', 'descriptor_name': 'Protoporphyrins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10715769900300711', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S23349031', 'display_name': 'Free Radical Research', 'issn_l': '1029-2470', 'issn': ['1029-2470', '1071-5762'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10499772', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.65, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W116293946', 'https://openalex.org/W1532386728', 'https://openalex.org/W1535575443', 'https://openalex.org/W1536654439', 'https://openalex.org/W1564577776', 'https://openalex.org/W1581414347', 'https://openalex.org/W1775749144', 'https://openalex.org/W1835897204', 'https://openalex.org/W1856033583', 'https://openalex.org/W1935339402', 'https://openalex.org/W1952402412', 'https://openalex.org/W1980307860', 'https://openalex.org/W1990412289', 'https://openalex.org/W1995382021', 'https://openalex.org/W1996290820', 'https://openalex.org/W2010094123', 'https://openalex.org/W2010291349', 'https://openalex.org/W2014034575', 'https://openalex.org/W2018823412', 'https://openalex.org/W2032259454', 'https://openalex.org/W2045690727', 'https://openalex.org/W2050166011', 'https://openalex.org/W2051486459', 'https://openalex.org/W206274772', 'https://openalex.org/W2066761741', 'https://openalex.org/W2074687883', 'https://openalex.org/W2082216248', 'https://openalex.org/W2093740207', 'https://openalex.org/W2101518804', 'https://openalex.org/W2114852835', 'https://openalex.org/W2137427549', 'https://openalex.org/W2201619502', 'https://openalex.org/W2413059681', 'https://openalex.org/W2425396469', 'https://openalex.org/W3141093834', 'https://openalex.org/W316989014', 'https://openalex.org/W4205153008', 'https://openalex.org/W4235018263', 'https://openalex.org/W4251084954', 'https://openalex.org/W4299317435', 'https://openalex.org/W4300591671', 'https://openalex.org/W4376495849'], 'related_works': ['https://openalex.org/W4290454241', 'https://openalex.org/W4206479330', 'https://openalex.org/W2431433609', 'https://openalex.org/W2331361650', 'https://openalex.org/W2316110543', 'https://openalex.org/W2135591948', 'https://openalex.org/W2126302704', 'https://openalex.org/W2069814953', 'https://openalex.org/W2043500658', 'https://openalex.org/W2036748683'], 'abstract_inverted_index': {'AbstractThe': [0], 'short-': [1], 'and': [2, 88, 170, 184, 213], 'long-term': [3], 'pro-oxidant': [4], 'effect': [5], 'of': [6, 19, 30, 38, 48, 62, 69, 86, 97, 101, 121, 136, 142, 160, 176, 182, 201, 205, 228, 245, 267, 281, 294], 'protoporphyrin': [7], 'IX': [8], '(PROTO)': [9], 'administration': [10], 'to': [11, 42, 56, 275, 285], 'mice': [12], 'was': [13, 23, 65, 73, 113, 148, 207, 254], 'studied': [14], 'in': [15, 269, 278], 'liver.': [16], 'A': [17], 'peak': [18], 'liver': [20, 63, 105, 260, 270, 289, 298], 'porphyrin': [21], 'accumulation': [22, 266, 293], 'found': [24], '2': [25, 115], 'h': [26, 54, 81, 116], 'after': [27, 82, 117, 133, 198, 241], 'the': [28, 36, 77, 83, 95, 98, 118, 127, 165, 180, 203, 226, 279, 282, 303], 'injection': [29, 85, 120], 'PROTO': [31, 49, 87, 102, 268], '(3.5': [32], 'mg/kg,': [33], 'i.p.);': [34], 'then': [35, 124], 'amount': [37], 'porphyrins': [39, 64, 295], 'diminished': [40], 'due': [41], 'biliar': [43], 'excretion.': [44], 'After': [45, 138], 'several': [46, 134], 'doses': [47, 135, 200], '(1': [50], 'dose': [51, 141, 244], 'every': [52], '24': [53], 'up': [55], '5': [57, 199], 'doses)': [58], 'a': [59, 139, 174, 242, 297], 'sustained': [60, 259], 'enhancement': [61], 'observed.': [66], 'The': [67], 'activity': [68, 181, 204, 253, 280], 'δ-amino-levulinic': [70], 'acid': [71], 'synthetase': [72], 'induced': [74, 103, 179, 192], '70–90%': [75], 'over': [76], 'control': [78, 128, 210, 249], 'values': [79, 129], '4': [80], 'first': [84, 119], 'stayed': [89], 'at': [90], 'these': [91], 'high': [92], 'levels': [93, 159, 191, 227], 'throughout': [94], 'period': [96], 'assay.': [99], 'Administration': [100], 'rapid': [104, 276], 'damage,': [106], 'involving': [107], 'lipid': [108, 171], 'peroxidation.': [109], 'Hepatic': [110], 'GSH': [111, 190, 229], 'content': [112], 'increased': [114], 'PROTO,': [122, 143, 202, 246], 'but': [123], 'decreased': [125, 189], 'below': [126], 'which': [130], 'were': [131, 230], 'maintained': [132], 'porphyrin.': [137], 'single': [140, 243], 'Cu-Zn': [144], 'superoxide': [145, 153], 'dismutase': [146], '(SOD)': [147], 'rapidly': [149], 'induced,': [150], 'suggesting': [151], 'that': [152, 265, 302], 'radicals': [154], 'had': [155], 'been': [156], 'generated.': [157], 'Increased': [158], 'hydrogen': [161], 'peroxide': [162], 'coming': [163], 'from': [164], 'reaction': [166], 'catalyzed': [167], 'by': [168], 'SOD': [169, 206], 'peroxides': [172], 'as': [173, 223, 225], 'consequence': [175], 'membrane': [177], 'peroxidation,': [178], 'catalase': [183, 214], 'glutathione': [185, 193], 'peroxidase': [186], '(GPx),': [187], 'while': [188, 219], 'reductase': [194], '(GRed)': [195], 'activity.': [196], 'However': [197], 'reduced': [208], 'reaching': [209], 'values.': [211], 'GPx': [212], 'activities': [215], 'slowly': [216], 'went': [217], 'down,': [218], 'GRed': [220], 'continued': [221], 'increasing': [222], 'long': [224], 'kept': [231], 'very': [232], 'low.': [233], 'TBARS': [234], 'values,': [235], 'although': [236], 'lower': [237], 'than': [238], 'those': [239], 'observed': [240], 'remained': [247], 'above': [248], 'values;': [250], 'Glutathione': [251], 'S-transferase': [252], 'instead': [255], 'greatly': [256], 'diminished,': [257], 'indicating': [258], 'damage.Our': [261], 'findings': [262], 'would': [263], 'indicate': [264], 'induces': [271], 'oxidative': [272], 'stress,': [273], 'leading': [274], 'increase': [277], 'antioxidant': [283, 304], 'enzymes': [284], 'avoid': [286], 'or': [287], 'revert': [288], 'damage.': [290], 'However,': [291], 'constant': [292], 'provokes': [296], 'damage': [299], 'so': [300], 'severe': [301], 'system': [305], 'is': [306], 'compromised.Keywords:': [307], 'Antioxidant': [308], 'enzymesliver': [309], 'damageoxidative': [310], 'stressporphyriasprotoporphyrin': [311]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2163933871', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 25}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-10T01:49:49.918430', 'created_date': '2016-06-24'}