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'recognized': [1094], 'fractions': [1097], 'containing': [1098], 'proteins': [1102], '("mitochondrial': [1103], 'associated': [1104], 'membranes")': [1105], 'isolated,': [1108], 'SR/ER-mitochondrial': [1113, 1646], 'tethering': [1114, 1197, 1220, 1772], 'remained': [1115], 'obscure': [1116], 'until': [1117], 'recently.': [1118], 'A': [1119, 1901, 2362, 2818], 'breakthrough': [1121], 'provided': [1123], 'experiments': [1125, 1179, 1206], 'nonexcitable': [1127, 1301, 1649, 1899], 'cells': [1128, 1182, 1539, 1650], 'demonstrating': [1129], 'mitofusin': [1134], '(MFN)': [1135], 'linking': [1140], 'organelles.12': [1143], 'ER': [1147, 1174, 1192], 'interacts': [1149], 'well': [1158], 'MFN1,': [1161], 'homologous': [1163], 'protein': [1164, 2364], 'located': [1165], 'solely': [1166], 'bring': [1173], 'together.': [1177], 'Reconstitution': [1178], 'knockout': [1181, 1456, 1470, 2076], 'shown,': [1184], 'however,': [1185, 1757, 1855, 1947], 'only': [1187], 'specifically': [1189, 1382], 'indispensable': [1194], 'process.In': [1198], 'present': [1200, 1874, 1914, 1995], 'study,': [1201], 'al': [1204, 1331, 1926], 'conduct': [1205], 'move': [1208], 'Drosophila': [1210, 1342], 'mice': [1212, 1367, 1457, 1999], 'interrogate': [1214], 'mitofusin-mediated': [1218], 'mitochondrial-SR': [1219], 'evolution.': [1223], 'starting': [1225], 'point': [1226], 'investigations': [1229], 'important': [1235, 1435], 'overcoming': [1237], 'low': [1239, 2020], 'efficiency': [1240], 'moving': [1245], 'authors': [1252], 'ask': [1253], 'how': [1254], 'created': [1257, 1366], 'cardiomyocytes,': [1259], 'what': [1261], 'their': [1263, 1703, 1723, 2205], 'downstream': [1264], 'consequences?': [1265], 'Because': [1266], 'reflect': [1268], 'apposition': [1271, 1647], 'investigators': [1277, 1715], 'sought': [1278], 'differentiate': [1280], 'hypotheses:': [1283], 'Was': [1284], 'nearness': [1286], 'organelles': [1289, 1665], 'mediated': [1292], 'MFN2,': [1298, 1378], 'cells?': [1302], 'Alternatively,': [1303], 'physical': [1306], 'sandwiching': [1307], 'T-tubules': [1312], 'itself,': [1316], 'sufficient': [1317], 'account': [1319], 'proximity?': [1323], 'To': [1324], 'sort': [1325], 'out': [1326], 'possibilities,': [1328], 'first': [1332], 'determined': [1333], 'effect': [1335], 'RNAi-mediated': [1337], 'suppression': [1338], 'sole': [1341], 'mitofusin,': [1343], 'MARF,': [1344], 'fruit': [1346], 'fly': [1347], 'tubes;': [1349], 'cytoplasma': [1356], 'increased,': [1357], 'possibly': [1358], 'reflecting': [1359], 'decreased': [1360, 1477], 'SR-to–mitochondrial': [1361], 'transfer.': [1363], 'Then,': [1364], 'they': [1365], 'vertebrate': [1374], 'mitofusins,': [1375], 'MFN1': [1376, 1392, 1416, 1469, 1983], 'individually': [1380], 'deleted': [1381], 'beginning': [1385], 'postnatal': [1387], 'life.': [1388], 'Comparing': [1389], 'ablation': [1390], 'controlled': [1395], 'potential': [1398, 1734], 'confounding': [1399], 'factor': [1400], 'mediator': [1405], '(along': [1406], 'MFN1)': [1408, 2005], 'fusion': [1410, 1425, 2580], 'Cardiomyocyte-specific': [1413], 'inactivation': [1414, 2001], 'would,': [1417], 'therefore,': [1418, 1960], 'same': [1421], 'effects': [1422, 2034], 'would': [1429, 1795, 2060, 2070], 'not': [1430, 1466, 1522, 1669, 1755, 1796, 1843, 1918, 1932, 1973, 2015, 2216], 'affect': [1431, 1933], 'SR-mitochondrial': [1432], 'coupling.The': [1433], 'finding': [1436], 'study': [1439, 1525, 1635, 1827, 1875, 1897, 1915, 1996], 'area': [1444, 1883], 'reduced': [1452], '≈30%': [1453], 'compared': [1459], 'wild': [1461, 1575], 'type': [1462, 1576], 'controls,': [1463], 'an': [1464, 2407], 'abnormality': [1465], 'observed': [1467, 1911], 'mice.': [1471, 2044], 'structural': [1473], 'uncoupling': [1474], 'correlated': [1475], 'transfer': [1482, 1498, 1533, 1587], 'isolated': [1484, 1783], 'cardiomyocyte': [1485, 2289], 'experiments.': [1486], 'Moreover,': [1487], 'conclusion': [1489], 'deletion': [1492, 1841, 1981], 'decreases': [1493, 1879], 'strengthened': [1500], 'observation': [1503], 'loss': [1505], 'actually': [1508], 'cytosol': [1512], 'release,': [1513], 'although': [1514], 'precise': [1516], 'mechanism': [1517], 'latter': [1520, 1659], 'known.': [1523], 'went': [1526], 'show': [1529], 'depressed': [1532], 'lacking': [1540], 'physiological': [1544], 'significance': [1545], 'impairs': [1548], 'cycle.': [1551], 'abnormalities': [1553], 'dramatic': [1556], 'workload,': [1561, 2058], 'modeled': [1563], 'isoproterenol': [1565], 'administration': [1566], 'combined': [1567, 1980], 'accelerated': [1569], 'rates': [1570, 1705], 'cellular': [1572], 'pacing.': [1573], 'transiently': [1578], 'augment': [1579], 'null': [1594], 'do': [1597], 'neither.': [1598], 'Taken': [1599], 'together,': [1600, 1666], 'data': [1602], 'indicate': [1603], 'likely': [1615], 'maintaining': [1617], 'intimacy': [1619], 'required': [1624], 'optimal': [1626], 'transfer.The': [1628], 'main': [1629], 'lesson': [1630], 'we': [1631], 'learn': [1632], 'commonality': [1639], 'exists': [1640, 2052], 'mechanisms': [1643], 'maintain': [1645], 'cardiomyocytes.': [1652], 'rigid': [1655], 'architecture': [1656], 'contribute': [1661], 'suffice': [1670], 'critical.': [1674], 'Given': [1675], 'conservation': [1677], 'MFNs,': [1679], 'why': [1680], 'consider': [1681], 'type-specific': [1684], 'differences': [1685], 'might': [1686], 'exist?': [1687], 'One': [1688, 1751], 'compelling': [1689], 'reason': [1690], 'already': [1695], 'differ': [1698, 1830], 'drastically': [1699], 'respect': [1701], 'glacial': [1704], 'fusion,13': [1708], 'another': [1709], 'key': [1710, 1742], 'function': [1711, 2041, 2585], 'proteins.The': [1714], 'excluded': [1716], 'many': [1717], 'alternative': [1720], 'explanations': [1721], 'data,': [1724], 'obvious': [1727], 'being': [1728], 'MFN2-related': [1729], 'alterations': [1730], 'electric': [1733], 'difference': [1735], 'driving': [1743], 'force': [1744], 'import': [1747], 'possibility': [1752], 'investigated,': [1756], 'whether': [1759], 'plays': [1761], 'direct': [1763, 2287], 'uptake,': [1768], 'independent': [1769], 'notion': [1778], 'could': [1779], 'tested': [1781], 'using': [1782], 'currently': [1788], 'no': [1789], 'evidence': [1790], 'hypothesis,': [1793], 'surprising': [1798, 2017], 'yet': [1803], 'functions.': [1805], 'vein,': [1808], 'implicated': [1812], 'sensitivity': [1816], 'permeability': [1820, 2626], 'transition': [1821, 2627], 'pore.14,15The': [1822], 'results': [1823], 'current': [1826], 'appear': [1828], 'those': [1832, 2218], 'Papanicolaou': [1834, 1924, 1976, 2594], 'al,': [1836], 'who': [1837], 'concluded': [1838], 'alter': [1844], 'relationship': [1846], 'cardiomyocytes.14': [1852], 'discrepancy,': [1854], 'largely': [1859], 'result': [1861], 'variation': [1863], 'parameters': [1866], 'were': [1868, 1972], 'assessed.': [1869], 'conclusions': [1871], 'based': [1877], 'similar': [1888], 'parameter': [1892], 'evaluated': [1893], 'initial': [1896], 'cells.12': [1900], 'trend': [1902], 'toward': [1903], 'distance': [1905, 1935], 'did': [1917], 'statistical': [1920], 'significance.': [1921], 'contrast,': [1923, 1993], 'absence': [1930], 'magnitude': [1943], 'distance,': [1946], 'much': [1949], 'than': [1951], 'gap': [1953], 'may,': [1959], 'obscured': [1962], 'small': [1963], 'changes': [1964], 'latter.': [1967], 'Rates': [1968], 'assessed': [1974], 'al.Mice': [1978], 'manifest': [1986], 'spontaneous': [1988], 'dilated': [1990], 'cardiomyopathy.13': [1991], 'shows': [1997], '(or': [2004], 'alone': [2006], 'normal': [2008], 'dimensions': [2010], 'function.': [2012], 'given': [2018], 'metabolic': [2021], 'basal': [2025], 'state.': [2026], 'It': [2027], 'will': [2028], 'interesting': [2030], 'test': [2032], 'various': [2036], 'energy-demanding': [2037], 'stresses': [2038], 'If': [2045], 'pathway': [2047], 'described': [2048], 'report': [2051], 'match': [2054], 'bioenergetics': [2055], 'one': [2059], 'predict': [2061], 'preload,': [2065], 'afterload,': [2066], 'chronotropy,': [2067], 'inotropy': [2069], 'poorly': [2072], 'tolerated': [2073], 'mice.Sources': [2077], 'FundingThis': [2079], 'supported': [2082, 2184], 'grants': [2084], 'National': [2086, 2890], 'Institutes': [2087], 'Health': [2089, 2133], '(5R01HL060665-14': [2090], '[R.N.K.],': [2091, 2093, 2095], '5P30CA013330-39': [2092], '5P60DK020541-34': [2094], '5R01HL106059-02': [2096], '[W.J.L.],': [2097, 2099], '5R01HL105239-02': [2098], '5P01AG025532-05': [2101], '[R.R.]);': [2102], 'Leducq': [2103], 'North': [2104], 'American-European': [2105], 'Atrial': [2106, 2743], 'Fibrillation': [2107], 'Alliance': [2109], 'European': [2111, 2146], 'Union': [2112, 2147], 'Seventh': [2113], 'Framework': [2114], 'Program': [2115], '(FP7)': [2116], 'Georg': [2117], 'August': [2118, 2346], 'University,': [2119], '"Identification': [2120], 'therapeutic': [2122], 'targeting': [2123], 'common': [2125], 'arrhythmia': [2126], 'trigger': [2127], 'mechanisms"': [2128], 'Italian': [2130, 2163], 'Ministries': [2131], '(Ricerca': [2134], 'Finalizzata)': [2135], 'Education,': [2138], '(PRIN,': [2142], 'FIRB)': [2143], '(R.R.);': [2144, 2157, 2161, 2169, 2172], '(ERC': [2148], 'mitoCalcium,': [2149], 'no.': [2150, 2155], '294777': [2151], 'FP7': [2153], '"MyoAGE,"': [2154], '223576)': [2156], 'Cariparo': [2158], 'Foundation': [2159, 2178], '(Padua)': [2160], 'Association': [2164], '(AIRC)': [2168], 'Telethon-Italy': [2170], '(GPP1005A)': [2171], 'A.': [2175, 2680], 'G.': [2176], 'Leventis': [2177], '(K.K.).': [2179], 'Dr.': [2187], 'Gerald': [2188], 'Myra': [2190], 'Dorros': [2191], 'Chair': [2192], 'Disease.': [2195], 'We': [2196], 'grateful': [2199], 'ongoing': [2206], 'generosity': [2207], 'support.DisclosuresNone.FootnotesThe': [2209], 'opinions': [2210], 'expressed': [2211], 'article': [2214], 'necessarily': [2217], 'editors': [2221], 'American': [2225, 3002], 'Heart': [2226, 2839, 3003], 'Association.Correspondence': [2227], 'Kitsis,': [2231], 'Forchheimer': [2237], 'G46,': [2238], '1300': [2239], 'Morris': [2240], 'Park': [2241], 'Avenue,': [2242], '10461.': [2245], 'E-mail': [2246], 'richard.[email': [2247], 'protected]yu.eduReferences1.': [2248], 'Clapham': [2249], 'DE.': [2250], 'Calcium': [2251], 'signaling.': [2252, 2335], 'Cell.': [2253], '2007;': [2254], '131:1047–1058.CrossrefMedlineGoogle': [2255], 'Scholar2.': [2256], 'Y,': [2258, 2270, 2389, 2574, 2576, 2644, 2650, 2866], 'Csordás': [2259, 2265], 'G,': [2260, 2484, 2777, 2781, 2963], 'Jowdy': [2261], 'C,': [2262, 2504, 2767, 2773, 2785, 2901], 'Schneider': [2263], 'TG,': [2264], 'N,': [2266], 'Wang': [2267], 'W,': [2268, 2450, 2854], 'Liu': [2269, 2575], 'Kohlhaas': [2271], 'M,': [2272, 2274, 2385, 2422, 2424, 2761, 2850, 2903, 2911, 2915], 'Meiser': [2273], 'Bergem': [2275], 'S,': [2276, 2480, 2648, 2687, 2779, 2864], 'Nerbonne': [2277], 'JM,': [2278, 2379, 2695], 'Dorn': [2279, 2577, 2661], 'GW,': [2280, 2662], 'Maack': [2281], 'C.': [2282, 2327], 'Mitofusin': [2283, 2562], '2-containing': [2284], 'mitochondrial-reticular': [2285], 'bioenergetic': [2290], 'responses': [2291], 'inter-organelle': [2293], 'crosstalk.': [2295], 'Circ': [2296, 2589], 'Res.2012;': [2297], '111:863–875.LinkGoogle': [2298], 'Scholar3.': [2299], 'McCormack': [2300], 'JG,': [2301], 'Halestrap': [2302], 'AP,': [2303], 'Denton': [2304], 'RM.': [2305], 'Role': [2306, 2738], 'ions': [2309], 'regulation': [2311], 'mammalian': [2313], 'intramitochondrial': [2314], 'metabolism.': [2315], 'Physiol': [2316], 'Rev.': [2317], '1990;': [2318], '70:391–425.CrossrefMedlineGoogle': [2319], 'Scholar4.': [2320], 'R': [2322], 'DSD,': [2323], 'Rafaello': [2324], 'A,': [2325, 2355, 2601, 2917], 'Mammucari': [2326], 'sensors': [2330], 'regulators': [2332], 'Nat': [2336], 'Rev': [2337], 'Mol': [2338, 2498, 2631, 2714], 'Biol.': [2340, 2633, 2715], 'August1,': [2341], '2012.': [2342, 2348], 'doi:10.1038/nrm3412.': [2343], 'http://www.nature.com/nrm/journal/vaop/ncurrent/full/nrm3412.html.': [2344], 'Accessed': [2345], '22,': [2347], 'CrossrefMedlineGoogle': [2349], 'Scholar5.': [2350], 'De': [2351, 2861], 'Stefani': [2352], 'D,': [2353, 2769, 2783, 2812, 2965], 'Raffaello': [2354], 'Teardo': [2356], 'E,': [2357, 2660, 2905, 2907], 'Szabo': [2358], 'I,': [2359, 2603, 2913], 'R.': [2361], 'forty-kilodalton': [2363], 'uniporter.': [2373, 2414], 'Nature.': [2374, 2415, 2569], '2011;': [2375, 2416, 2554, 2591, 2634], '476:336–340.CrossrefMedlineGoogle': [2376], 'Scholar6.': [2377], 'Baughman': [2378], 'Perocchi': [2380], 'F,': [2381, 2506], 'Girgis': [2382], 'HS,': [2383], 'Plovanich': [2384], 'Belcher-Timme': [2386], 'CA,': [2387], 'Sancak': [2388], 'Bao': [2390], 'XR,': [2391], 'Strittmatter': [2392], 'L,': [2393, 2689, 2727, 2729, 2763, 2775, 2860, 2961], 'Goldberger': [2394], 'O,': [2395], 'Bogorad': [2396], 'RL,': [2397], 'Koteliansky': [2398], 'V,': [2399, 2852, 2858], 'Mootha': [2400], 'VK.': [2401], 'Integrative': [2402], 'genomics': [2403], 'identifies': [2404], 'mcu': [2405], 'essential': [2408, 2582], 'component': [2409], '476:341–345.CrossrefMedlineGoogle': [2417], 'Scholar7.': [2418], 'R,': [2420, 2446, 2856], 'Brini': [2421], 'Murgia': [2423], 'Pozzan': [2425, 2459], 'T.': [2426, 2460], 'ca2+': [2430, 2471], 'ip3-sensitive': [2433], 'neighboring': [2439], 'Science.': [2441, 2473], '1993;': [2442], '262:744–747.CrossrefMedlineGoogle': [2443], 'Scholar8.': [2444], 'Pinton': [2447], 'P,': [2448, 2765, 2816], 'Carrington': [2449], 'Fay': [2451], 'FS,': [2452], 'Fogarty': [2453], 'KE,': [2454], 'Lifshitz': [2455], 'LM,': [2456], 'Tuft': [2457], 'RA,': [2458], 'Close': [2461], 'contacts': [2462], 'endoplasmic': [2465, 2565], 'determinants': [2468], 'responses.': [2472], '1998;': [2474], '280:1763–1766.CrossrefMedlineGoogle': [2475], 'Scholar9.': [2476], 'Chikando': [2477, 2532, 2600], 'AC,': [2478, 2533, 2642], 'Kettlewell': [2479], 'Williams': [2481, 2530, 2962], 'GS,': [2482, 2531], 'Smith': [2483], 'WJ.': [2486, 2697], 'dynamics': [2488, 2796], '-': [2492], 'state': [2493], 'art.': [2496], 'J': [2497, 2919], 'Cardiol.2011;': [2500], '51:627–631.CrossrefMedlineGoogle': [2501], 'Scholar10.': [2502], 'Franzini-Armstrong': [2503, 2872], 'Protasi': [2505], 'Ramesh': [2507], 'V.': [2508], 'Shape,': [2509], 'size,': [2510], 'distribution': [2512], 'ca': [2514], '2+': [2515], 'units': [2517], 'couplons': [2519], 'skeletal': [2521], 'muscles.': [2524], 'Biophys': [2525, 2552, 2713], 'J.': [2526, 2553], '1999;': [2527], '77:1528–1539.CrossrefMedlineGoogle': [2528], 'Scholar11.': [2529], 'Tuan': [2534], 'HT,': [2535], 'Sobie': [2536, 2684], 'EA,': [2537, 2685], 'WJ,': [2539, 2613], 'Jafri': [2540], 'MS.': [2541], 'Dynamics': [2542], 'sparks': [2545], 'leak': [2548, 2700], '101:1287–1296.CrossrefMedlineGoogle': [2555], 'Scholar12.': [2556], 'de': [2557, 2730], 'Brito': [2558], 'OM,': [2559], 'Scorrano': [2560], 'L.': [2561], 'tethers': [2564], '2008;': [2570], '456:605–610.CrossrefMedlineGoogle': [2571], 'Scholar13.': [2572], 'GW.': [2578], 'Mitochondrial': [2579, 2740, 2950], 'organelle': [2584], 'homeostasis.': [2588], 'Res.': [2590], '109:1327–1331.LinkGoogle': [2592], 'Scholar14.': [2593], 'KN,': [2595], 'Khairallah': [2596], 'RJ,': [2597], 'Ngoh': [2598], 'GA,': [2599], 'Luptak': [2602], "O'Shea": [2604], 'KM,': [2605], 'Riley': [2606], 'DD,': [2607], 'Lugus': [2608], 'JJ,': [2609], 'Colucci': [2610], 'WS,': [2611], 'Stanley': [2614], 'WC,': [2615], 'Walsh': [2616], 'K.': [2617], 'Mitofusin-2': [2618], 'maintains': [2619], 'structure': [2621], 'contributes': [2623], 'stress-induced': [2625], 'myocytes.': [2630], '31:1309–1328.CrossrefMedlineGoogle': [2635], 'Scholar15.': [2636], 'Whelan': [2637], 'RS,': [2638], 'K,': [2640], 'Wei': [2641], 'Reyna': [2645], 'DE,': [2646], 'Jha': [2647], 'Yang': [2649], 'Calvert': [2651], 'JW,': [2652], 'Lindsten': [2653], 'T,': [2654, 2814], 'Thompson': [2655], 'CB,': [2656], 'Crow': [2657], 'MT,': [2658], 'Gavathiotis': [2659], "O'Rourke": [2663], 'B,': [2664], 'RN.': [2666], 'Bax': [2667], 'necrosis': [2670], 'dynamics.': [2673], 'Proc': [2674], 'Natl': [2675], 'Acad': [2676], 'Sci': [2677], 'U': [2678], 'S': [2679, 2790], '2012;': [2681], '109:6566–6571.CrossrefMedlineGoogle': [2682], 'Scholar16.': [2683], 'Guatimosim': [2686], 'Gomez-Viquez': [2688], 'Song': [2690], 'LS,': [2691], 'Hartmann': [2692], 'H,': [2693, 2868], 'Saleet': [2694], 'ca(2+)': [2699, 2707], 'paradox': [2701], '"rogue': [2703], 'receptors":': [2705], 'Sr': [2706], 'efflux': [2708], 'theory': [2709], 'practice.': [2711], 'Prog': [2712], '2006;': [2716], '90:172–185.CrossrefMedlineGoogle': [2717], 'Scholar': [2718], 'Previous': [2719], 'Back': [2720], 'top': [2722], 'Next': [2723], 'FiguresReferencesRelatedDetailsCited': [2724], 'By': [2725], 'Pool': [2726], 'Wijdeveld': [2728], 'Groot': [2731], 'N': [2732], 'Brundel': [2734], 'B': [2735, 2945], '(2021)': [2736, 2822], 'Dysfunction': [2741], 'Fibrillation:': [2744], 'Translation': [2745], 'Druggable': [2747], 'Target': [2748], 'Biomarker': [2750], 'Discovery,': [2751], 'International': [2752], 'Journal': [2753, 2801, 2978], 'Molecular': [2755, 2980], '10.3390/ijms22168463,': [2757], '22:16,': [2758], '(8463)': [2759], 'Forte': [2760], 'Schirone': [2762], 'Ameri': [2764], 'Basso': [2766], 'Catalucci': [2768], 'Modica': [2770], 'J,': [2771, 2909], 'Chimenti': [2772], 'Crotti': [2774], 'Frati': [2776], 'Rubattu': [2778], 'Schiattarella': [2780], 'Torella': [2782], 'Perrino': [2784], 'Indolfi': [2786], 'C': [2787, 2873], 'Sciarretta': [2789], '(2020)': [2791], 'cardiovascular': [2798], 'diseases,': [2799], 'British': [2800], 'Pharmacology,': [2803], '10.1111/bph.15068,': [2804], '178:10,': [2805], '(2060-2076),': [2806], 'Online': [2807, 2845, 2896, 2940, 2956, 2987], 'publication': [2808, 2846, 2897, 2941, 2957, 2988], 'date:': [2809, 2847, 2898, 2942, 2958, 2989], '1-May-2021.': [2810, 2848], 'Miranda-Silva': [2811], 'Lima': [2813], 'Rodrigues': [2815], 'Leite-Moreira': [2817], 'Falcão-Pires': [2820], 'I': [2821, 2967], 'Mechanisms': [2823], 'underlying': [2824], 'pathophysiology': [2826], 'failure': [2829], 'preserved': [2831], 'ejection': [2832], 'fraction:': [2833], 'tip': [2835], 'iceberg,': [2838], 'Failure': [2840], 'Reviews,': [2841], '10.1007/s10741-020-10042-0,': [2842], '26:3,': [2843], '(453-478),': [2844], 'Lavorato': [2849], 'Iyer': [2851], 'Dewight': [2853], 'Cupo': [2855], 'Debattisti': [2857], 'Gomez': [2859], 'la': [2862], 'Fuente': [2863], 'Zhao': [2865], 'Valdivia': [2867], 'Hajnóczky': [2869], 'G': [2870], '(2017)': [2874], 'Increased': [2875], 'nanotunneling': [2877], 'activity,': [2878], 'induced': [2879], 'imbalance,': [2882], 'affects': [2883], 'intermitochondrial': [2884], 'exchanges,': [2886], 'Proceedings': [2887], 'Academy': [2891], '10.1073/pnas.1617788113,': [2894], '114:5,': [2895], '31-Jan-2017.': [2899], 'Fernandez-Sanz': [2900], 'Ruiz-Meana': [2902], 'Miro-Casas': [2904], 'Nuñez': [2906], 'Castellano': [2908], 'Loureiro': [2910], 'Barba': [2912], 'Poncelas': [2914], 'Rodriguez-Sinovas': [2916], 'Vázquez': [2918], 'Garcia-Dorado': [2921], 'D': [2922], '(2014)': [2923], 'Defective': [2924], 'reticulum–mitochondria': [2926], 'exchange': [2928], 'aged': [2930], 'mouse': [2931], 'myocardium,': [2932], 'Death': [2934], '&': [2935], 'Disease,': [2936], '10.1038/cddis.2014.526,': [2937], '5:12,': [2938], '(e1573-e1573),': [2939], '1-Dec-2014.': [2943], 'Hill': [2944], '(2013)': [2946, 2971], 'Recent': [2947], 'Advances': [2948], '113:12,': [2954], '(e107-e110),': [2955], '6-Dec-2013.': [2959], 'Boyman': [2960], 'Khananshvili': [2964], 'Sekler': [2966], 'W': [2970], 'NCLX:': [2972], 'sodium': [2975], 'exchanger,': [2977], 'Cellular': [2982], 'Cardiology,': [2983], '10.1016/j.yjmcc.2013.03.012,': [2984], '59,': [2985], '(205-213),': [2986], '1-Jun-2013.': [2990], 'September': [2991], '14,': [2992, 3009], '2012Vol': [2993], 'Issue': [2995], '7': [2996], 'Advertisement': [2997, 3013], 'Article': [2998], 'InformationMetrics': [2999], '©': [3000], '2012': [3001, 3010], 'Association,': [3004], 'Inc.https://doi.org/10.1161/CIRCRESAHA.112.277269PMID:': [3005], '22982869': [3006], 'publishedSeptember': [3008], 'PDF': [3011], 'download': [3012]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2163906599', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-09-11T16:17:29.991042', 'created_date': '2016-06-24'}