Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2163568784', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-14-0821', 'title': 'Twisting and Ironing: Doxorubicin Cardiotoxicity by Mitochondrial DNA Damage', 'display_name': 'Twisting and Ironing: Doxorubicin Cardiotoxicity by Mitochondrial DNA Damage', 'publication_year': 2014, 'publication_date': '2014-06-11', 'ids': {'openalex': 'https://openalex.org/W2163568784', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-14-0821', 'mag': '2163568784', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24916696', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4204112'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-14-0821', 'pdf_url': 'https://clincancerres.aacrjournals.org/content/clincanres/20/18/4737.full.pdf', 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://clincancerres.aacrjournals.org/content/clincanres/20/18/4737.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072102696', 'display_name': 'Karin C. Nitiss', 'orcid': 'https://orcid.org/0000-0002-3548-5090'}, 'institutions': [{'id': 'https://openalex.org/I4210110323', 'display_name': 'University of Illinois Chicago, Rockford campus', 'ror': 'https://ror.org/02437s643', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238', 'https://openalex.org/I4210110323']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Karin C. Nitiss', 'raw_affiliation_strings': ['1Biomedical Sciences Department, UIC College of Medicine and', '2Department of Biopharmaceutical Sciences, UIC College of Pharmacy, Rockford, Illinois.'], 'affiliations': [{'raw_affiliation_string': '1Biomedical Sciences Department, UIC College of Medicine and', 'institution_ids': []}, {'raw_affiliation_string': '2Department of Biopharmaceutical Sciences, UIC College of Pharmacy, Rockford, Illinois.', 'institution_ids': ['https://openalex.org/I4210110323']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5022566853', 'display_name': 'John L. Nitiss', 'orcid': 'https://orcid.org/0000-0002-1013-4972'}, 'institutions': [{'id': 'https://openalex.org/I4210110323', 'display_name': 'University of Illinois Chicago, Rockford campus', 'ror': 'https://ror.org/02437s643', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238', 'https://openalex.org/I4210110323']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'John L. Nitiss', 'raw_affiliation_strings': ['1Biomedical Sciences Department, UIC College of Medicine and', '2Department of Biopharmaceutical Sciences, UIC College of Pharmacy, Rockford, Illinois.'], 'affiliations': [{'raw_affiliation_string': '1Biomedical Sciences Department, UIC College of Medicine and', 'institution_ids': []}, {'raw_affiliation_string': '2Department of Biopharmaceutical Sciences, UIC College of Pharmacy, Rockford, Illinois.', 'institution_ids': ['https://openalex.org/I4210110323']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5022566853'], 'corresponding_institution_ids': ['https://openalex.org/I4210110323'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.321, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.999958, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '20', 'issue': '18', 'first_page': '4737', 'last_page': '4739'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11535', 'display_name': 'Chemotherapy-induced cardiotoxicity and mitigation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11535', 'display_name': 'Chemotherapy-induced cardiotoxicity and mitigation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12381', 'display_name': 'Electron Spin Resonance Studies', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cardiotoxicity', 'display_name': 'Cardiotoxicity', 'score': 0.9876634}], 'concepts': [{'id': 'https://openalex.org/C2778233292', 'wikidata': 'https://www.wikidata.org/wiki/Q2118956', 'display_name': 'Cardiotoxicity', 'level': 3, 'score': 0.9876634}, {'id': 'https://openalex.org/C2781303535', 'wikidata': 'https://www.wikidata.org/wiki/Q18936', 'display_name': 'Doxorubicin', 'level': 3, 'score': 0.85271466}, {'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.60057503}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.57014364}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5317152}, {'id': 'https://openalex.org/C24586158', 'wikidata': 'https://www.wikidata.org/wiki/Q27075', 'display_name': 'Mitochondrial DNA', 'level': 3, 'score': 0.50252295}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.4868857}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42483443}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3460642}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.29970634}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28200054}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.24335906}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12580898}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12315363}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.057120204}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D066126', 'descriptor_name': 'Cardiotoxicity', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066126', 'descriptor_name': 'Cardiotoxicity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-14-0821', 'pdf_url': 'https://clincancerres.aacrjournals.org/content/clincanres/20/18/4737.full.pdf', 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4204112', 'pdf_url': 'https://europepmc.org/articles/pmc4204112?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204112', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24916696', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-14-0821', 'pdf_url': 'https://clincancerres.aacrjournals.org/content/clincanres/20/18/4737.full.pdf', 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1968482171', 'https://openalex.org/W1974605412', 'https://openalex.org/W1988079533', 'https://openalex.org/W2027956728', 'https://openalex.org/W2036225919', 'https://openalex.org/W2041051519', 'https://openalex.org/W2044590638', 'https://openalex.org/W2059514724', 'https://openalex.org/W2093153514', 'https://openalex.org/W2097388785', 'https://openalex.org/W2137194369', 'https://openalex.org/W2140182328'], 'related_works': ['https://openalex.org/W4390534911', 'https://openalex.org/W4388041187', 'https://openalex.org/W4385199638', 'https://openalex.org/W4323666172', 'https://openalex.org/W3030216814', 'https://openalex.org/W3011400996', 'https://openalex.org/W2738785033', 'https://openalex.org/W2143449387', 'https://openalex.org/W2094475704', 'https://openalex.org/W2056299406'], 'abstract_inverted_index': {'Abstract': [0], 'Anthracyclines': [1], 'are': [2, 36], 'active': [3], 'clinical': [4], 'agents': [5], 'that': [6, 31], 'have': [7], 'multiple': [8], 'mechanisms': [9, 23], 'of': [10, 19, 48], 'cytotoxicity.': [11], 'Cardiotoxicity': [12], 'by': [13], 'anthracyclines': [14], 'limits': [15], 'the': [16], 'therapeutic': [17], 'potential': [18], 'these': [20], 'agents,': [21], 'but': [22], 'leading': [24], 'to': [25, 38], 'cardiotoxicity': [26, 44], 'remain': [27], 'controversial.': [28], 'Transgenic': [29], 'mice': [30], 'lack': [32], 'mitochondrial': [33, 49], 'topoisomerase': [34], 'I': [35], 'hypersensitive': [37], 'doxorubicin': [39], 'cardiotoxicity,': [40], 'providing': [41], 'support': [42], 'for': [43], 'arising': [45], 'from': [46], 'damage': [47], 'DNA.': [50], 'Clin': [51], 'Cancer': [52], 'Res;': [53], '20(18);': [54], '4737–9.': [55], '©2014': [56], 'AACR.': [57]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2163568784', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-13T20:22:26.249204', 'created_date': '2016-06-24'}