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3769, 3780, 3795, 3851, 3853, 3979, 4113, 4131, 4135, 4151, 4211, 4357, 4364, 4381, 4395, 4405, 4416, 4468, 4481, 4489, 4513], 'the': [3, 12, 23, 30, 37, 44, 52, 55, 68, 97, 104, 135, 147, 156, 167, 174, 181, 188, 196, 199, 212, 241, 248, 279, 299, 302, 331, 375, 392, 422, 468, 845, 902, 949, 957, 1073, 1129, 1191, 1242, 1290, 1309, 1388, 1447, 1545, 1553, 1617, 1639, 1645, 1672, 1710, 1714, 1717, 1728, 1772, 1803, 1810, 1816, 1840, 1931, 1962, 2048, 2068, 2127, 2138, 2148, 2172, 2183, 2193, 2198, 2258, 2265, 2275, 2282, 2344, 2374, 2379, 2383, 2392, 2628, 2658, 2672, 2691, 2707, 2741, 2749, 2768, 2784, 2813, 3027, 3110, 3195, 3229, 3349, 3364, 3368, 3371, 3431, 3447, 3453, 3472, 3481, 3492, 3520, 3539, 3558, 3562, 3606, 3635, 3670, 3683, 3686, 3692, 3695, 3698, 3714, 3721, 3728, 3752, 3773, 3781, 3787, 3792, 3805, 3830, 3839, 3854, 3995, 4005, 4064, 4068, 4111, 4119, 4148, 4209, 4298, 4346, 4349, 4355, 4358, 4365, 4384, 4396, 4402, 4406, 4414, 4417, 4427, 4461, 4466, 4469, 4486, 4492, 4501, 4504, 4510], 'p53': [4, 148, 289, 312, 379, 393, 419, 461, 477, 647, 737, 887, 905, 952, 1143, 1272, 1415, 1721, 1738, 1799, 1885, 1889, 1897, 2427, 3741, 3785, 3809, 3817, 4001, 4221, 4382], 'tumor': [5, 149, 290, 1205, 1236, 1256], 'suppressor': [6, 150, 291], 'protein': [7, 18, 57, 99, 151, 162, 201, 243, 292, 424, 644, 1195, 1397, 1549, 1674, 1732, 3484, 3865, 4066], 'is': [8, 41, 100, 152, 185, 244, 313, 384, 421, 890, 953, 1132, 1287, 1446, 1462, 1550, 2625, 3533, 3557, 4192, 4228, 4437], 'critically': [9, 153], 'regulated': [10, 154], 'by': [11, 22, 33, 61, 92, 155, 166, 177, 205, 236, 466, 471, 481, 956, 1082, 1089, 1401, 1410, 1930, 1961, 1997, 2039, 2044, 2237, 2251, 2288, 2308, 2321, 2340, 2377, 2577, 2632, 2639, 2650, 2681, 2758, 2828, 2909, 3050, 3071, 3138, 3212, 3219, 3241, 3274, 3359, 3415, 3573, 3812, 4019, 4122, 4154, 4472, 4516], 'Hdm2': [13, 17, 27, 157, 161, 171, 2562, 2565, 2574, 2583, 2586, 2630, 3108], 'and': [14, 28, 126, 142, 158, 172, 270, 286, 315, 335, 441, 473, 653, 738, 851, 881, 898, 946, 962, 1088, 1255, 1265, 1383, 1403, 1590, 1631, 1658, 1664, 1680, 1692, 1702, 1720, 1739, 1815, 1839, 1860, 1872, 1883, 1906, 1917, 1928, 1995, 2042, 2058, 2093, 2158, 2249, 2257, 2267, 2286, 2327, 2335, 2459, 2518, 2564, 2580, 2585, 2662, 2706, 2713, 2721, 2738, 2755, 2783, 2790, 2798, 2820, 2839, 2915, 2932, 2951, 2954, 2975, 2997, 3075, 3082, 3136, 3198, 3248, 3343, 3357, 3370, 3455, 3460, 3505, 3690, 3742, 3756, 3784, 3804, 3821, 4004, 4012, 4043, 4143, 4202], 'Hdmx': [15, 47, 74, 86, 98, 125, 159, 191, 218, 230, 242, 269, 1118, 1194, 1233, 1250, 1264, 1274, 1444, 1460, 1548, 1731, 2123, 2952, 3200, 3422, 3776, 3782, 3820, 3856, 3980, 3997, 4042, 4114, 4301, 4359, 4385, 4462, 4482, 4505], 'proteins.': [16, 160], 'levels': [19, 163, 1192, 1295, 1376, 3768, 3779, 4377], 'are': [20, 88, 164, 232, 965, 1267, 1298, 1377, 2190, 2871, 3789, 4205], 'auto-regulated': [21, 165], 'self-ubiquitination': [24, 168], 'activity': [25, 169, 420, 462, 840, 2977, 4009], 'on': [29, 103, 173, 247, 330, 886, 2239, 2684, 2761, 2929, 3056, 3080, 4348, 4361], 'transcriptional': [31, 175], 'level': [32, 176, 1312, 1442, 1733], 'p53-activated': [34, 178, 4304], 'transcription': [35, 179, 469, 657, 1662, 3679, 3872, 4037, 4049, 4058, 4120, 4152, 4305, 4363, 4372, 4393, 4403, 4490, 4515], 'hdm2': [38, 182, 1147], 'gene.': [39, 183], 'Little': [40, 184, 783, 813, 1047, 2007, 3160, 3293, 3386, 3933, 4082, 4163], 'known': [42, 186, 1288], 'about': [43, 187, 1289], 'regulation': [45, 189, 470, 950, 1270, 1445, 1712], 'expression': [48, 192, 1231, 1275, 1294, 2349, 2557, 3098, 3705, 4002], 'levels,': [49, 193, 1276], 'apart': [50, 194], 'from': [51, 195, 391, 1823, 1837, 1848, 1867, 2064, 2107, 2131, 2147, 2386, 2400, 2457, 2466, 2552, 2627, 3502, 3637, 4491], 'observation': [53, 197, 4299], 'that': [54, 85, 198, 229, 727, 879, 893, 959, 1072, 1117, 1128, 1292, 1302, 1374, 1395, 1404, 1457, 3450, 3615, 3669, 4110, 4197, 4300], 'Mdmx': [56, 200, 645, 728, 850, 880, 899, 945, 1375, 1396], 'can': [58, 202, 654, 972, 1398, 1407, 4116, 4302], 'be': [59, 121, 203, 265, 387, 973, 1197, 1260, 1281, 1399, 1408, 1697, 4127], 'cleaved': [60, 204, 1400], 'caspase-3': [62, 206, 1402, 2330], 'in': [63, 207, 297, 371, 381, 426, 463, 901, 948, 975, 1085, 1095, 1134, 1142, 1199, 1234, 1269, 1742, 1877, 1911, 1926, 1973, 2152, 2163, 2453, 2472, 2495, 2521, 2731, 2808, 2873, 2876, 2923, 2959, 2980, 3000, 3087, 3103, 3123, 3129, 3146, 3255, 3345, 3354, 3434, 3471, 3480, 3511, 3604, 3620, 3786, 3791, 4031, 4208, 4224, 4230, 4306, 4438, 4457, 4477], 'a': [64, 208, 294, 368, 484, 976, 1122, 1135, 1473, 1588, 2051, 2150, 2397, 2464, 2549, 2635, 2667, 2697, 2702, 2718, 2779, 2795, 2971, 2981, 3139, 3528, 3567, 3621, 3708, 3718, 3747, 3848], 'p53-inducible': [65, 209], 'manner.': [66, 210], 'In': [67, 211, 304, 968, 1583, 3277, 3440, 4343], 'functional': [69, 137, 213, 281, 378], 'analysis': [70, 214, 1090, 3040], 'two': [72, 78, 216, 222, 464, 1620, 2159, 3445], 'mutant': [73, 217, 2394, 3112, 3199], 'proteins,': [75, 219, 1722, 4388], 'products': [76, 220, 2234, 2243, 2297], 'alternatively': [79, 223], 'spliced': [80, 224], 'mRNAs,': [81, 225], 'it': [82, 128, 226, 272, 889, 1391, 4072], 'was': [83, 227, 1126, 1313, 1681, 1747, 1771, 1835, 1846, 2062, 2101, 2118, 2155, 2319, 2396, 2455, 2548, 2575, 2648, 2679, 2968, 2978, 3152, 3189, 3210, 3239, 3285, 3352, 3378, 3810, 4010, 4496], 'found': [84, 228, 1127, 1190, 1301, 1695, 3668, 4229, 4497], 'proteins': [87, 231, 1461, 1649, 3151, 3201, 3377, 3688, 3716, 3783, 3857, 4204, 4360, 4463, 4483, 4506], 'targets': [89, 233, 1698], 'for': [90, 129, 234, 273, 478, 1652, 1665, 1699, 1727, 2223, 2559, 2736, 2989, 3126, 3333, 4016], 'ubiquitination': [91, 235, 1701], 'Mdm2.': [93, 237, 1670], 'partly': [101, 245, 4055, 4117, 4400], 'dependent': [102, 246, 329], 'presence': [105, 249, 1243], 'its': [107, 251, 1450], 'internal': [108, 252], 'acidic': [109, 253, 1640], 'domain.': [110, 254, 1647], 'Mdm2': [111, 255, 423, 459, 652, 739, 852, 882, 897, 947, 1266, 1278, 1542, 1679, 1743, 2348, 2665, 2852, 2863, 3188, 4033, 4369], 'appears': [112, 256], 'only': [113, 257, 4399], 'to': [114, 120, 123, 258, 264, 267, 306, 319, 386, 1196, 1239, 1253, 1259, 1655, 1668, 1684, 1696, 1806, 2121, 2168, 2179, 3425, 3624, 3758, 3807, 3869, 4039, 4194, 4226, 4345, 4375], 'require': [115, 259], 'an': [116, 260, 842, 1078, 2227, 2722, 2774, 2799, 3512, 3536, 3547], 'intact': [117, 261], 'RING': [118, 262, 846, 2393, 4112], 'domain': [119, 263, 2647, 3522, 3832], 'able': [122, 266], 'ubiquitinate': [124, 268, 731], 'target': [127, 271], 'proteasomal': [130, 274, 479], 'degradation.': [131, 275, 1686, 1703], 'These': [132, 276, 1648, 1704, 3487], 'findings': [133, 277], 'highlight': [134, 278], 'intricate': [136, 280], 'relationships': [138, 282], 'between': [139, 283, 844, 1464, 1716, 2325], 'p53,': [140, 284, 472, 1544, 2944, 3761, 3771, 4142, 4155, 4473], 'Mdm2,': [141, 285, 1719, 2373, 2678, 3994, 4141], 'Hdmx.': [143, 287, 3496], 'plays': [293], 'major': [295, 416], 'role': [296, 370], 'maintaining': [298], 'integrity': [300], 'genome.': [303], 'response': [305, 526, 566], 'various': [307], 'forms': [308], 'cellular': [310, 373], 'stress': [311, 336], 'stabilized': [314, 736], 'activated,': [316], 'which': [317, 1626, 1723, 3456, 3613, 3828, 4389], 'leads': [318], 'induction': [320], 'cell': [322, 1086, 1206, 1380, 1466, 1470, 3028, 3350], 'cycle': [323], 'arrest,': [324], 'DNA': [325, 1307, 1362, 1385, 1586, 2252, 2309], 'repair,': [326], 'or': [327, 732, 1144, 1296, 1543, 1953, 2046, 2141, 2176, 2371, 2836, 2845, 3092, 3096, 3102, 3109, 3204, 3264, 3327, 4138, 4218, 4386], 'apoptosis,': [328], 'type': [332, 1246, 1414, 2425, 2686, 2763, 4000], 'cells': [334, 1237, 1874, 1908, 2066, 2927, 3077, 3119, 3224, 3323, 3369, 3990, 4308], '(1Lane': [337], 'D.P.': [338, 713, 816, 824, 2410, 3296, 3304, 3389, 3397], 'Benchimol': [339], 'S.': [340, 617, 786, 854, 856, 2010, 2412, 2436, 2554, 3163, 3936, 4085, 4166], 'Genes': [341, 2361, 2614], 'Dev.': [342, 450, 2362, 2615], '1990;': [343, 2444], '4:': [344], '1-8Crossref': [345], 'PubMed': [346, 361, 410, 436, 454, 580, 595, 611, 637, 693, 718, 750, 774, 806, 834, 870, 935, 991, 1009, 1038, 1062, 1108, 1183, 1351, 1368, 1434, 1506, 1534, 1578, 1609, 1764, 1948, 2030, 2214, 2366, 2417, 2447, 2488, 2513, 2538, 2619, 2901, 3183, 3314, 3407, 3598, 3662, 3909, 3924, 3956, 3969, 4105, 4186, 4264, 4292, 4323, 4338, 4451], 'Scopus': [347, 362, 411, 437, 455, 581, 596, 612, 638, 694, 719, 751, 775, 807, 835, 871, 936, 992, 1010, 1039, 1063, 1109, 1184, 1352, 1369, 1435, 1507, 1535, 1579, 1610, 1765, 1949, 2031, 2215, 2367, 2418, 2448, 2489, 2514, 2539, 2620, 2902, 3184, 3315, 3408, 3599, 3663, 3910, 3925, 3957, 3970, 4106, 4187, 4265, 4293, 4324, 4339, 4452], '(766)': [348], 'Google': [349, 364, 413, 439, 457, 583, 598, 614, 640, 696, 721, 753, 777, 809, 837, 873, 938, 994, 1012, 1041, 1065, 1111, 1169, 1186, 1228, 1354, 1371, 1437, 1509, 1537, 1581, 1612, 1767, 1796, 1951, 2033, 2217, 2369, 2420, 2450, 2491, 2516, 2541, 2622, 2904, 3186, 3317, 3410, 3601, 3665, 3912, 3927, 3959, 3972, 4108, 4189, 4267, 4295, 4326, 4341, 4454], 'Scholar,': [350, 584, 599, 615, 697, 754, 778, 810, 995, 1013, 1042, 1170, 1510, 3913, 3928, 3960, 4268, 4327], '2Vousden': [351, 400], 'K.H.': [352, 401, 590, 623, 2892], 'Lu': [353, 402], 'X.': [354, 403], 'Nat.': [355, 404, 1057, 2533], 'Rev.': [356, 405], 'Cancer.': [357, 406, 1179], '2002;': [358, 407, 433, 451, 927, 1035, 1431, 1498, 1526, 1570, 1606, 4256, 4284], '2:': [359, 408, 832, 3312, 3405], '594-604Crossref': [360, 409], '(2669)': [363, 412], 'Scholar).': [365, 414, 458, 641, 722, 838, 874, 939, 1066, 1112, 1187, 1229, 1355, 1438, 1538, 1582, 1613, 1768, 1797, 2034, 2218, 2421, 2451, 2542, 2623, 2905, 3187, 3318, 3411, 3602, 3973, 4190, 4296, 4342], 'With': [366], 'such': [367], 'pivotal': [369], 'numerous': [372], 'processes,': [374], 'frequency': [376], 'inactivation': [380, 903], 'human': [382, 1092, 1138, 1204, 2426, 3559], 'cancer': [383], 'expected': [385], 'higher': [388], 'than': [389, 1201], 'estimated': [390], 'mutation': [394], 'alone': [395, 3101, 4115, 4217], '(for': [396], 'review': [397], 'see': [398], 'Ref.': [399, 1096, 2473, 2496, 2522], 'regulator': [417], '(reviewed': [425, 1094], 'Refs.': [427], '3Alarcon-Vargas': [428], 'D.': [429, 443, 915, 1015, 1019, 1486, 1512, 1514, 1556, 1558, 2401, 2404, 2500, 2595, 4244, 4270, 4272], 'Ronai': [430, 2604], 'Z.': [431, 2605], 'Carcinogenesis.': [432], '23:': [434, 2511, 2899], '541-547Crossref': [435], '(180)': [438], 'Scholar': [440], '4Michael': [442], 'Oren': [444, 574, 2359, 2469, 2480, 2505, 2612], 'M.': [445, 575, 670, 864, 1023, 1153, 1328, 1421, 2360, 2468, 2481, 2506, 2571, 2591, 2601, 2613, 3886, 4329], 'Curr.': [446], 'Opin.': [447], 'Genet.': [448, 1058, 2534], '&': [449], '12:': [452], '53-59Crossref': [453], '(242)': [456], 'inhibits': [460, 4056], 'ways:': [465], 'blocking': [467], 'also': [474, 1120, 3545, 4045, 4353], 'through': [475, 4129], 'targeting': [476], 'degradation': [480], 'acting': [482], 'as': [483, 651, 1077, 1080, 1935, 1959, 2000, 2114, 2666, 3085, 3154, 3288, 3381, 4156, 4499], 'RING-type': [485], 'E3': [486], '1The': [487], 'abbreviations': [488, 528], 'used': [489, 529, 2156], 'are:': [490, 530], 'E3,': [491, 531], 'ubiquitin-protein': [492, 532], 'isopeptide': [493, 533], 'ligase;': [494, 534], 'HRP,': [495, 535], 'horseradish': [496, 536, 1807], 'peroxidase;': [497, 537], 'aa,': [498, 538], 'amino': [499, 539, 2642, 2654, 2675, 2744, 3477, 3488, 3516, 3632], 'acids;': [500, 540], 'CMV,': [501, 541], 'cytomegalovirus;': [502, 542], 'DAPI,': [503, 543], '4,6-diamino-2-phenylindole;': [504, 544], 'DMEM,': [505, 545], "Dulbecco's": [506, 546], 'modified': [507, 547], "Eagle's": [508, 548], 'medium;': [509, 549], 'FBS,': [510, 550, 3246], 'fetal': [511, 551], 'bovine': [512, 552], 'serum;': [513, 553], 'FITC,': [514, 554], 'fluorescein': [515, 555, 1863], 'isothiocyanate;': [516, 556], 'HA,': [517, 557], 'hemagglutinin;': [518, 558], 'PBS,': [519, 559, 3124, 3135], 'phosphate-buffered': [520, 560], 'saline;': [521, 561], 'RT-PCR,': [522, 562], 'reverse': [523, 563, 2104], 'transcriptase;': [524, 564], 'REs,': [525, 565], 'elements.1The': [527], 'elements.': [567], '(5Haupt': [568], 'Y.': [569, 2354, 2477, 2502, 2504, 2607], 'Maya': [570], 'R.': [571, 601, 780, 812, 818, 1000, 1151, 1212, 1518, 1562, 1780, 2004, 2589, 2883, 2885, 3157, 3292, 3298, 3385, 3391, 3578, 3642, 3930, 4079, 4160, 4276], 'Kazaz': [572], 'A.': [573, 659, 701, 862, 986, 1021, 1025, 1046, 1317, 1423, 1425, 2498, 3875], 'Nature.': [576, 591, 987, 1005], '1997;': [577, 592, 608], '387:': [578, 593], '296-299Crossref': [579], '(3624)': [582], '6Kubbutat': [585], 'M.H.': [586], 'Jones': [587], 'S.N.': [588, 980], 'Vousden': [589, 622, 2891], '299-303Crossref': [594], '(2796)': [597], '7Honda': [600], 'Tanaka': [602], 'H.': [603, 605, 909, 913, 1480, 1484, 4238, 4242], 'Yasuda': [604], 'FEBS': [606, 865], 'Lett.': [607, 866], '420:': [609], '25-27Crossref': [610], '(1574)': [613], '8Fang': [616], 'Jensen': [618], 'J.P.': [619], 'Ludwig': [620], 'R.L.': [621], 'Weissman': [624], 'A.M.': [625], 'J.': [626, 689, 763, 788, 795, 907, 919, 924, 1044, 1098, 1155, 1157, 1178, 1214, 1347, 1478, 1490, 1495, 1523, 1567, 1602, 1753, 1782, 2012, 2019, 2077, 2752, 3165, 3172, 3587, 3651, 3905, 3938, 3945, 4087, 4094, 4168, 4175, 4236, 4248, 4253, 4281], 'Biol.': [627, 746, 764, 796, 925, 1034, 1364, 1496, 1524, 1568, 1605, 1760, 2020, 2484, 2897, 3173, 3588, 3652, 3920, 3946, 4095, 4176, 4254, 4282, 4319], 'Chem.': [628, 765, 797, 926, 1497, 1525, 1569, 2021, 3174, 3589, 3653, 3947, 4096, 4177, 4255, 4283], '2000;': [629, 747, 798, 1105, 2022, 3175, 3921, 3948, 4097, 4178, 4320], '275:': [630, 799, 2023, 3176, 3949, 4098, 4179], '8945-8951Abstract': [631], 'Full': [632, 634, 769, 771, 801, 803, 930, 932, 1501, 1503, 1529, 1531, 1573, 1575, 2025, 2027, 3178, 3180, 3593, 3595, 3657, 3659, 3951, 3953, 4100, 4102, 4181, 4183, 4259, 4261, 4287, 4289], 'Text': [633, 635, 770, 772, 802, 804, 931, 933, 1502, 1504, 1530, 1532, 1574, 1576, 2026, 2028, 3179, 3181, 3594, 3596, 3658, 3660, 3952, 3954, 4101, 4103, 4182, 4184, 4260, 4262, 4288, 4290], 'PDF': [636, 773, 805, 934, 1505, 1533, 1577, 2029, 3182, 3597, 3661, 3955, 4104, 4185, 4263, 4291], '(857)': [639], 'Mdm2-related': [643], 'binds': [646], 'with': [648, 1241, 1468, 1657, 1880, 1914, 1954, 1992, 2047, 2067, 2095, 2103, 2226, 2582, 2690, 2714, 2767, 2791, 2913, 2934, 2970, 2995, 3017, 3021, 3032, 3093, 3105, 3134, 3142, 3191, 3202, 3205, 3244, 3329, 3341, 3717, 3725, 3760, 3772, 3819, 3822, 3826, 3844, 3993, 4074, 4140, 4220, 4310, 4383, 4413, 4423, 4426, 4440, 4500], 'similar': [649, 1123, 3719, 3849], 'requirements': [650], 'inhibit': [655, 1660, 3870, 4047, 4118, 4303], 'p53-induced': [656, 1661, 3678, 4036, 4048], '(9Shvarts': [658, 1316, 3874], 'Steegenga': [660, 1318, 3876], 'W.T.': [661, 1319, 3877], 'Riteco': [662, 1320, 3878], 'N.': [663, 784, 1321, 2008, 3161, 3879, 3934, 4083, 4164], 'van': [664, 671, 674, 677, 682, 706, 789, 819, 1217, 1322, 1329, 1332, 1335, 1340, 1785, 2013, 3166, 3299, 3392, 3880, 3887, 3890, 3893, 3898, 3939, 4088, 4169], 'Laar': [665, 1323, 3881], 'T.': [666, 1324, 2073, 2358, 2603, 3882], 'Dekker': [667, 1325, 3883], 'P.': [668, 1326, 2475, 2888, 3884], 'Bazuine': [669, 1327, 3885], 'Ham': [672, 1330, 3888], 'R.C.': [673, 1331, 3889], 'der': [675, 683, 707, 790, 820, 1218, 1333, 1341, 1786, 1938, 2014, 3167, 3300, 3393, 3891, 3899, 3940, 4089, 4170], 'Houven': [676, 1334, 3892], 'Oordt': [678, 1336, 3894], 'W.': [679, 1050, 1337, 3895], 'Hateboer': [680, 1338, 3896], 'G.': [681, 921, 1004, 1056, 1102, 1163, 1176, 1339, 1492, 2208, 3580, 3644, 3897, 4250], 'Eb': [684, 708, 791, 821, 1219, 1342, 1787, 1939, 2015, 3168, 3301, 3394, 3900, 3941, 4090, 4171], 'A.J.': [685, 709, 792, 822, 1220, 1343, 1757, 1788, 1940, 2016, 3169, 3302, 3395, 3901, 3942, 4091, 4172], 'Jochemsen': [686, 710, 793, 827, 916, 1020, 1053, 1221, 1344, 1426, 1487, 1789, 2017, 2893, 3170, 3307, 3400, 3902, 3943, 3963, 4092, 4173, 4245, 4445], 'A.G.': [687, 711, 794, 828, 917, 1054, 1222, 1345, 1427, 1488, 1790, 2018, 2894, 3171, 3308, 3401, 3903, 3944, 3964, 4093, 4174, 4246, 4446], 'EMBO': [688, 829, 1346, 3309, 3402, 3904], '1996;': [690, 1348, 2485, 3906], '15:': [691, 1349, 2617, 3907], '5349-5357Crossref': [692, 1350, 3908], '(504)': [695, 1353, 3911], '10Bottger': [698], 'V.': [699, 1052, 1755, 2204], 'Bottger': [700], 'Garcia-Echeverria': [702], 'C.': [703, 1598, 2408, 2479, 2753], 'Ramos': [704, 781, 2005, 3158, 3931, 4080, 4161], 'Y.F.': [705, 782, 1210, 1778, 2006, 3159, 3932, 4081, 4162], 'Lane': [712, 823, 2409, 3303, 3396], 'Oncogene.': [714, 1430, 2413, 3965, 4447], '1999;': [715, 766, 867, 1166, 1365, 3590, 3654], '18:': [716, 1366], '189-199Crossref': [717], '(148)': [720], 'However,': [723, 1248, 1284], 'transfection': [724, 1925, 1957, 3322, 4017], 'studies': [725, 877], 'indicated': [726], 'could': [729, 1675, 4507], 'not': [730, 1285, 1314, 1676, 3825, 4146, 4431, 4508], 'degrade,': [733], 'but': [734, 3736, 3824], 'instead': [735], '(11Jackson': [740, 4313], 'M.W.': [741, 1359, 3915, 4314], 'Berberich': [742, 1360, 3916, 4315, 4332], 'S.J.': [743, 1361, 2434, 3917, 4316, 4333], 'Mol.': [744, 1032, 1603, 1758, 2482, 2895, 3918, 4317], 'Cell.': [745, 1033, 1604, 1759, 2483, 2896, 3919, 4318], '20:': [748, 2415, 3922, 3967, 4321, 4449], '1001-1007Crossref': [749, 3923, 4322], '(182)': [752, 3926, 4325], '12Sharp': [755], 'D.A.': [756], 'Kratowicz': [757], 'S.A.': [758], 'Sank': [759], 'M.J.': [760, 1149, 1172], 'George': [761], 'D.L.': [762], '274:': [767, 3591, 3655], '38189-38196Abstract': [768], '(233)': [776, 1950], '13Stad': [779, 3929], 'Grivell': [785, 2009, 3162, 3935, 4084, 4165], 'Attema': [787, 1213, 1781, 2011, 3164, 3937, 4086, 4167], '28039-28044Abstract': [800, 2024, 3177, 3950, 4099, 4180], '(119)': [808, 2032, 3185, 3958, 4107, 4188], '14Stad': [811], 'N.A.': [814, 1048, 3294, 3387, 3962, 4444], 'Xirodimas': [815, 2402, 3295, 3388], 'Frenk': [817, 2882, 3297, 3390], 'Saville': [825, 2405, 3305, 3398], 'M.K.': [826, 2406, 3306, 3399], 'Rep.': [830, 3310, 3403], '2001;': [831, 1059, 1225, 1793, 2211, 2414, 2616, 3311, 3404, 3966, 4448], '1029-1034Crossref': [833, 3313, 3406], '(184)': [836, 3316, 3409], 'This': [839, 3554, 4124], 'requires': [841], 'interaction': [843], 'finger': [847], 'domains': [848], '(15Tanimura': [853], 'Ohtsuka': [855], 'Mitsui': [857], 'K.': [858, 860, 1027, 4331], 'Shirouzu': [859], 'Yoshimura': [861], 'Ohtsubo': [863], '447:': [868], '5-9Crossref': [869], '(266)': [872], 'Although': [875, 4060], 'these': [876, 1235], 'suggest': [878, 1116], 'have': [883, 1628, 1725], 'opposite': [884], 'effects': [885], 'stability,': [888], 'very': [891, 3675], 'possible': [892], 'under': [894], 'certain': [895, 1304], 'conditions': [896], 'cooperate': [900], '(16Gu': [906, 1477, 4235], 'Kawai': [908, 1479, 4237], 'Nie': [910, 1481, 4239], 'L.': [911, 1482, 1600, 4240], 'Kitao': [912, 1483, 4241], 'Wiederschain': [914, 1485, 4243], 'Parant': [918, 1489, 4247], 'Lozano': [920, 1003, 1055, 1491, 2207, 4249], 'Yuan': [922, 1493, 4251], 'Z.M.': [923, 1494, 4252], '277:': [928, 1499, 1527, 1571, 4257, 4285], '19251-19254Abstract': [929, 1500, 4258], '(207)': [937, 1508, 4266], 'critical': [941], 'importance': [942], 'both': [944, 960, 969, 1263, 1688, 4214], 'best': [954], 'illustrated': [955], 'observations': [958], 'mdm2-null': [961], 'mdmx-null': [963], 'mice': [964], 'embryonic': [966], 'lethal.': [967], 'cases,': [970], 'lethality': [971], 'rescued': [974], 'p53-null': [977], 'background': [978], '(17Jones': [979], 'Roe': [981], 'A.E.': [982], 'Donehower': [983], 'L.A.': [984], 'Bradley': [985], '1995;': [988, 1006, 2510], '378:': [989, 1007], '206-208Crossref': [990], '(1051)': [993], '18Montes': [996], 'de': [997, 2886], 'Oca': [998], 'Luna': [999], 'Wagner': [1001], 'D.S.': [1002], '203-206Crossref': [1008], '(1190)': [1011], '19Migliorini': [1014], 'Denchi': [1016], 'E.L.': [1017], 'Danovi': [1018, 1513, 1557, 4271], 'Capillo': [1022], 'Gobbi': [1024], 'Helin': [1026], 'Pelicci': [1028, 1519, 1563, 4277], 'P.G.': [1029, 1520, 1564, 4278], 'Marine': [1030, 1521, 1565, 2754, 2889, 4279], 'J.C.': [1031, 1522, 1566, 2890, 4280], '22:': [1036, 1607], '5527-5538Crossref': [1037], '(255)': [1040], '20Parant': [1043], 'Chavez-Reyes': [1045], 'Yan': [1049], 'Reinke': [1051, 2203], '29:': [1060], '92-95Crossref': [1061], '(405)': [1064], 'It': [1067, 1125, 1453, 4191, 4495], 'has': [1068, 1392, 1454, 1594, 2429, 3866], 'been': [1069, 1393, 1455, 1595, 2430, 3867], 'generally': [1070], 'accepted': [1071], 'mdm2': [1074, 2384, 2688, 2765], 'gene': [1075, 1131, 2200, 3433], 'functions': [1076, 3684], 'oncogene,': [1079], 'shown': [1081, 1394, 1456, 3790], 'transformation': [1083, 1254], 'experiments': [1084, 4412], 'culture': [1087, 3237], 'tumors': [1093], '21Momand': [1097], 'Wu': [1099], 'H.H.': [1100], 'Dasgupta': [1101], 'Gene': [1103, 2209], '(Amst.).': [1104, 2210], '242:': [1106], '15-29Crossref': [1107], '(512)': [1110], 'More': [1113], 'recent': [1114], 'data': [1115, 1705], 'might': [1119, 1280, 1724, 4126], 'perform': [1121], 'function.': [1124, 3984], 'hdmx': [1130, 2256, 2285, 3432, 3548, 3607, 3710], 'amplified': [1133], 'subset': [1136], 'gliomas': [1139], 'without': [1140], 'mutations': [1141], 'amplification': [1145, 2146, 2683, 2760], '(22Riemenschneider': [1148], 'Buschges': [1150], 'Wolter': [1152], 'Reifenberger': [1154, 1162, 1175], 'Bostrom': [1156], 'Kraus': [1158], 'J.A.': [1159, 2528], 'Schlegel': [1160], 'U.': [1161], 'Cancer': [1164, 1223, 1791], 'Res.': [1165, 1224, 1792, 2509], '59:': [1167], '6091-6096PubMed': [1168], '23Riemenschneider': [1171], 'Knobbe': [1173], 'C.B.': [1174], 'Int.': [1177], '2003;': [1180, 2898, 4335], '104:': [1181], '752-757Crossref': [1182], '(79)': [1185], 'Moreover,': [1188], 'we': [1189, 1627, 3437, 3443, 3457, 3544, 3667, 3762, 4352, 4474], 'increased': [1198, 1315], 'more': [1200, 2874], '30%': [1202], 'lines': [1207, 1471], 'tested': [1208, 3811], '(24Ramos': [1209, 1777], 'Stad': [1211, 1779, 2884], 'Peltenburg': [1215, 1783], 'L.T.': [1216, 1784], '61:': [1226, 1794], '1839-1842PubMed': [1227, 1795], 'Aberrant': [1230], 'appeared': [1238], 'correlate': [1240], 'wild': [1245, 1413, 2424, 2685, 2762, 3999], 'p53.': [1247, 4123], 'whether': [1249, 3976, 4476], 'actually': [1251], 'contributes': [1252], 'formation': [1257], 'remains': [1258], 'determined.': [1261], 'Because': [1262, 4460], 'important': [1268, 4193], 'activity,': [1273], 'like': [1277], 'expression,': [1279], 'strictly': [1282], 'regulated.': [1283], 'much': [1286], 'ways': [1291], 'Hdmx/Mdmx': [1293], 'activities': [1297], 'controlled.': [1299], 'We': [1300, 1614, 3974], 'after': [1303, 1384, 2303, 3117, 3235, 3267, 3321, 3627, 3842], 'types': [1305], 'damage': [1308], 'mdmx': [1310, 2199, 3564], 'mRNA': [1311, 3464, 3499, 3549], 'Another': [1356], 'report': [1357, 1615, 4077], '(25Jackson': [1358], 'Cell': [1363, 1870], '693-700Crossref': [1367], '(27)': [1370], 'Scholar)': [1372, 1952, 2092, 2370, 4109, 4455], 'suggests': [1373], 'constant': [1378], 'during': [1379], 'growth,': [1381], 'differentiation,': [1382], 'damage.': [1386], 'On': [1387], 'other': [1389, 4231], 'hand,': [1390], 'this': [1405, 3441, 3983, 3987, 4478], 'cleavage': [1406, 2331], 'stimulated': [1409], 'activation': [1411, 1663, 1736, 3873, 4050, 4121, 4153, 4373, 4394, 4404, 4467], '(26Gentiletti': [1416], 'F.': [1417, 1419, 1429], 'Mancini': [1418], "D'Angelo": [1420], 'Sacchi': [1422], 'Pontecorvi': [1424], 'Moretti': [1428], '21:': [1432], '867-877Crossref': [1433], '(35)': [1436], 'A': [1439, 2080], 'completely': [1440], 'different': [1441, 1465, 2160, 3715, 3774, 3996], 'control': [1448, 1729], 'subcellular': [1451], 'localization.': [1452], 'localization': [1458, 1476], 'distinct': [1463], 'lines,': [1467], 'most': [1469], 'showing': [1472], 'predominantly': [1474], 'cytoplasmic': [1475, 2060], '27Migliorini': [1511, 4269], 'Colombo': [1515, 1559, 4273], 'E.': [1516, 1560, 2356, 2611, 2881, 4274], 'Carbone': [1517, 1561, 4275], '7318-7323Abstract': [1528, 1572, 4286], '(67)': [1536, 1580, 1611, 4294], 'Upon': [1539], 'co-expression': [1540, 4034], 'majority': [1546], 'translocated': [1551], 'into': [1552, 1709, 2246, 2264, 2300, 2312, 2388, 2925, 3703, 3707], 'nucleus': [1554, 4210], '(27Migliorini': [1555], 'addition,': [1584], 'following': [1585], 'damage,': [1587], 'p53-': [1589], 'Mdm2-independent': [1591], 'nuclear': [1592], 'translocation': [1593], 'described': [1596, 1936, 1960, 2001, 2431, 2471, 2494, 2520, 2581, 2872, 3086, 3155, 3289, 3382, 3572], '(28Li': [1597], 'Chen': [1599, 1601], '7562-7571Crossref': [1608], 'here': [1616, 4196], 'identification': [1618], 'new': [1621, 1707], 'splicing': [1622, 2260, 3428, 3448, 3555, 3673, 3700, 3978], 'variants': [1623, 2261, 3429, 3449], 'Hdmx,': [1625, 1690, 1718, 3197, 4136, 4200], 'called': [1629, 3458], 'Hdmx-A': [1630, 1633, 1673, 3459, 3483, 3689, 3755, 4044, 4387], 'Hdmx-G.': [1632, 3461], 'lacks': [1634, 1644, 3465, 3500, 3829, 4067], 'exon': [1635, 2132, 2142, 2153, 2164, 2188, 3466, 3508, 3526, 3551, 3608, 3617, 3671], '9': [1636, 3467], 'sequences': [1637, 2130, 2652, 3501, 3726], 'encoding': [1638, 2274, 2391, 2423, 2653, 3107, 3727], 'domain,': [1641, 4071], 'whereas': [1642, 4053], 'Hdmx-G': [1643, 1693, 3757, 4054, 4065, 4139, 4203], 'p53-binding': [1646, 3521, 3831, 4070], 'were': [1650, 1694, 1821, 1865, 1875, 1909, 1920, 1971, 2037, 2220, 2235, 2244, 2262, 2279, 2298, 2338, 2351, 2463, 2567, 2729, 2748, 2756, 2806, 2826, 2911, 2921, 2987, 2993, 3030, 3048, 3054, 3069, 3078, 3120, 3217, 3225, 3253, 3272, 3324, 3337, 3413, 3701, 3723, 3799, 3991, 4014, 4026], 'characterized': [1651, 3444], 'their': [1653, 1666, 3733], 'ability': [1654, 1667, 3753, 3806], 'associate': [1656, 3759], 'subsequently': [1659, 2998], 'stabilize': [1669, 1678], 'Surprisingly,': [1671], 'significantly': [1677, 4046, 4390], 'particularly': [1682], 'susceptible': [1683], 'Mdm2-triggered': [1685], 'Importantly,': [1687], 'full-length': [1689], 'Hdmx-A,': [1691, 3735, 3823, 4137, 4201], 'Mdm2-induced': [1700], 'provide': [1706], 'insights': [1708], 'delicate': [1711], 'balance': [1715], 'implications': [1726], 'upon': [1734, 2192], 'stress-induced': [1735], 'subsequent': [1740, 3372], 'increase': [1741], 'levels.': [1744, 4041], 'Antibodies—Anti-Mdm2': [1745], 'antibody': [1746, 1750, 1770, 1801, 1820, 1833, 1844, 3846], 'mouse': [1748, 1841, 2687, 2764, 2814, 3192, 3563], 'monoclonal': [1749, 1800, 1819, 1831, 1842, 3063, 3193, 3206], '4B2': [1751], '(29Chen': [1752], 'Marechal': [1754], 'Levine': [1756], '1993;': [1761], '13:': [1762], '4107-4114Crossref': [1763], '(620)': [1766], 'Anti-Hdmx': [1769, 3052], 'rabbit': [1773, 1812, 3213], 'polyclonal': [1774, 1813, 3214], 'serum': [1775], 'p55': [1776, 3203], 'DO-1,': [1802], 'DO-1': [1804], 'coupled': [1805], 'peroxidase': [1808], '(HRP),': [1809], 'anti-p53': [1811], 'FL393,': [1814], '9E10': [1817, 2708, 2785], 'anti-Myc': [1818], 'obtained': [1822, 1836, 1847, 1866, 2456, 4425, 4456], 'Santa': [1824], 'Cruz': [1825], 'Biotechnology': [1826], '(Santa': [1827], 'Cruz,': [1828], 'CA).': [1829], 'anti-HA': [1832, 3064, 3802, 3845], 'H11': [1834, 3207], 'Babco,': [1838], 'anti-LacZ': [1843], 'D19–2F3-2': [1845], 'Roche': [1849], 'Applied': [1850, 1965, 2054], 'Science.': [1851, 2443], 'Secondary': [1852], 'antibodies': [1853, 3065], 'goat': [1854, 1856, 1858, 1861], 'anti-mouse-HRP,': [1855], 'anti-rabbit-HRP,': [1857], 'anti-mouse-Rhodamine,': [1859], 'anti-rabbit': [1862], 'isothiocyanate': [1864], 'Jackson': [1868], 'ImmunoResearch.': [1869], 'Lines': [1871], 'Transfections—H1299': [1873], 'grown': [1876, 2928], 'RPMI': [1878, 3242], 'supplemented': [1879, 1913, 1991, 3020, 3243], '10%': [1881, 1915, 3018, 3245], 'FBS': [1882, 1916], 'antibiotics.': [1884, 1918], '–': [1886, 1890, 1892, 1894, 1898, 1900, 1902], '/': [1887, 1891, 1895, 1899, 1903], '–,': [1888, 1896, 1904], '/mdm2': [1893], '/mdmx': [1901], 'U2OS,': [1905], 'C33A': [1907, 2065, 3435, 3764], 'maintained': [1910], 'DMEM': [1912, 1927], 'Cells': [1919, 3252, 3336], 'seeded': [1921, 3079], '6–16': [1922], 'h': [1923, 3116, 3234, 3266, 3320], 'before': [1924, 4158], 'transfected': [1929, 2933, 3084, 3227, 3763], 'calcium': [1932, 2963, 3230], 'phosphate': [1933, 2964, 3231], 'method': [1934, 2071, 2346, 2660], '(30van': [1937], 'Graham': [1941], 'F.L.': [1942], 'Methods': [1943], 'Enzymol.': [1944], '1980;': [1945], '65:': [1946], '826-839Crossref': [1947], 'FuGENE': [1955], '6': [1956, 3527, 3552, 3609, 3618, 3672], 'reagent': [1958], 'manufacturer': [1963], '(Roche': [1964, 2053], 'Science).': [1966, 2055], 'Western': [1967, 1998, 3038, 3072, 3275, 3360, 3416, 3813], 'Blot': [1968], 'Analysis—Cell': [1969], 'lysates': [1970, 3029, 3788], 'made': [1972, 2102, 2320, 2339, 2376, 2680, 2757], 'IPB': [1974, 3256, 3355], '0.7': [1975, 1981, 3257, 3356], '(20': [1976], 'mm': [1977, 3004, 3007, 3010], 'triethanolamine,': [1978], 'pH': [1979, 3012], '7.4,': [1980, 3013], 'm': [1982], 'NaCl,': [1983, 3005], '0.5%': [1984], 'Nonidet': [1985, 2069], 'P-40,': [1986], '0.2%': [1987, 3143], 'sodium': [1988], 'deoxycholic': [1989], 'acid': [1990], 'protease': [1993, 3022], 'inhibitors)': [1994], 'analyzed': [1996, 2236, 2250, 3070, 3273, 3358, 3414], 'blot': [1999, 3039, 3841], 'previously': [2002, 2432, 3290, 3383], '(13Stad': [2003, 3156, 4078, 4159], 'Protein': [2035, 3024], 'bands': [2036], 'detected': [2038, 3190, 3211], 'enhanced': [2040], 'chemiluminescence': [2041], 'visualized': [2043, 3218], 'autoradiography': [2045], 'use': [2049, 2692, 2769, 4415], 'Lumi-Imager': [2052], 'RNA': [2056, 2061, 2111], 'Isolation': [2057], 'RT-PCR—Total': [2059], 'isolated': [2063, 3546], 'P-40': [2070], '(31Maniatis': [2072], 'Fritsch': [2074], 'E.F.': [2075], 'Sambrook': [2076], 'Molecular': [2078], 'Cloning:': [2079], 'Laboratory': [2081, 2086], 'Manual.': [2082], 'Cold': [2083, 2088], 'Spring': [2084, 2089], 'Harbor': [2085], 'Press,': [2087], 'Harbor,': [2090], 'NY1982Google': [2091], 'treated': [2094, 3328], 'DNase': [2096], 'I': [2097], '(Promega).': [2098], 'Single-stranded': [2099], 'cDNA': [2100, 2385, 2689, 2766, 3565], 'transcriptase': [2105], '(Invitrogen)': [2106, 2248], '3': [2108, 2143], 'μg': [2109, 2936, 2946, 2956, 3044, 3058], 'using': [2112, 2343, 2657, 2663, 3062, 3228, 3801], 'oligo(dT)': [2113], 'primer.': [2115], 'Subsequently,': [2116], 'PCR': [2117, 2233, 2242, 2289, 2296, 2682, 2727, 2759, 2804, 2910], 'carried': [2119, 2221], 'out': [2120, 2222], 'detect': [2122, 3713], 'cDNAs.': [2124], 'Primers': [2125], 'at': [2126, 2281, 2832, 2841, 3258, 3732, 4028], '5′-end': [2128, 2283], 'contained': [2129, 3452], '2': [2133], '(5′-GCAGTTTCTTCACTACC-3′;': [2134], 'just': [2135], 'upstream': [2136], 'first': [2139], 'ATG)': [2140], '(5′-TGCATGCAGCAGGTGCG-3′).': [2144], 'For': [2145, 3036], '3′-end': [2149], 'primer': [2151], '8': [2154, 3265], '(5′-CATTACTTCTAGGTGTAT-3′),': [2157], 'primers': [2161, 2695, 2716, 2772, 2793], 'located': [2162, 4207], '11': [2165], '(A,': [2166], 'up': [2167, 2178], 'nucleotide': [2169, 2180], '1172': [2170], 'within': [2171, 2182, 3491], 'coding': [2173, 2711, 2788], 'sequence': [2174, 2307, 2712, 2789], '5′-CCAATCCTTCCTCAAGGC-3′,': [2175], 'B,': [2177], '1894': [2181], '3′-untranslated': [2184], 'region': [2185], '5′-GGTTCACCTAACTATGTA-3′).': [2186], 'numbers': [2189], 'based': [2191], 'published': [2194], 'genomic': [2195], 'organization': [2196], '(32Parant': [2201], 'J.M.': [2202], 'Mims': [2205], 'B.': [2206, 2442, 2532, 2578, 3582, 3646], '270:': [2212], '277-283Crossref': [2213], '(18)': [2216], 'PCRs': [2219], '35': [2224], 'cycles': [2225], 'annealing': [2228], 'temperature': [2229], '55': [2231], '°C.': [2232], 'electrophoresis': [2238], 'agarose': [2240], 'gels.': [2241], 'cloned': [2245, 2263, 2280, 2299, 2730, 2807], 'pCR2.1-TOPO': [2247, 2301], 'sequencing.': [2253], 'Plasmid': [2254, 2390, 2422], 'Constructs—Full-length': [2255], 'alternative': [2259, 3427, 3631, 3687, 3699, 3977], 'XhoI': [2266], 'BamHI': [2268, 2698], 'sites': [2269, 2825], 'pCDNA3.1Myc-His': [2271], '(Invitrogen).': [2272, 2733, 2810], 'Sequences': [2273], 'hemagglutinin': [2276, 3729], '(HA)': [2277, 3730], 'tag': [2278, 3731], 'hdmx-G': [2287, 3498], '(5′': [2290], 'primer,': [2291, 2294], '5′-GATCAAGCTTACCATGGCTTACCCATACGATGTTCCAGATTACGCGTCGAGGCCGGGATCCACATCATTTTCCACCTGCTC-3′;': [2292], '3′': [2293, 2715, 2792], '5′-ACATCATTTTCCACCTCTGCTC-3′).': [2295], 'and,': [2302], 'confirmation': [2304], 'correct': [2306], 'sequencing,': [2310], 'subcloned': [2311], 'Hdmx-pcDNA3.1Myc-His': [2313], 'via': [2314], 'XbaI': [2315, 2323], 'sites.': [2316], 'HA-Hdmx-A': [2317], 'pcDNA3.1Myc-His': [2318, 2454], 'exchanging': [2322], 'fragments': [2324, 2728, 2805], 'HA-hdmx': [2326], 'hdmx-A.': [2328], 'mutants': [2332], 'Hdmx(-A)': [2333, 2336], 'D361A': [2334], 'C362Stop': [2337], 'site-directed': [2341], 'mutagenesis': [2342], 'QuickChange': [2345, 2829], '(Stratagene).': [2347], 'plasmids': [2350, 2907], 'Mdm2-X2': [2352, 2387], '(33Barak': [2353], 'Gottlieb': [2355], 'Juven-Gershon': [2357], '1994;': [2363], '8:': [2364], '1739-1749Crossref': [2365], '(285)': [2368], 'pcDNA3.1': [2372, 2645, 2664, 2669, 2732, 2809, 2818, 2821, 2848, 2859, 3704], 'latter': [2375], 'recloning': [2378], 'EcoRI': [2380, 2723, 2775, 2800], 'fragment': [2381, 2637, 2917], 'containing': [2382, 2696, 2717, 2773, 2794, 3697, 3766], 'pcDNA3.1.': [2389], 'Mdm2-(C464A)': [2395], 'kind': [2398, 2550, 2568], 'gift': [2399, 2465, 2551, 2750], '(34Xirodimas': [2403], 'Edling': [2407], 'Lain': [2411], '4972-4983Crossref': [2416], '(155)': [2419], '(pC53-SN)': [2428], '(35Baker': [2433], 'Markowitz': [2435], 'Fearon': [2437], 'E.R.': [2438], 'Willson': [2439], 'J.K.': [2440], 'Vogelstein': [2441, 2531, 2579], '249:': [2445], '912-915Crossref': [2446], '(1600)': [2449], 'CMV-LacZ': [2452, 2958], 'Invitrogen,': [2458], 'luciferase': [2460, 2938, 2976, 3088, 4024], 'reporter': [2461, 2939, 4408, 4419, 4429, 4471], 'constructs': [2462, 2817], 'Dr.': [2467, 2553], '(bax-luc': [2470], '36Friedlander': [2474], 'Haupt': [2476, 2501], 'Prives': [2478], '16:': [2486], '4961-4971Crossref': [2487], '(268)': [2490], 'Scholar;': [2492, 2517], 'mdm2-luc': [2493, 4418], '37Zauberman': [2497], 'Flusberg': [2499], 'Barak': [2503], 'Nucleic': [2507], 'Acids': [2508], '2584-2592Crossref': [2512], '(253)': [2515], 'p21-luc': [2519, 4407, 4470], '38el-Deiry': [2523], 'W.S.': [2524], 'Kern': [2525], 'S.E.': [2526], 'Pietenpol': [2527], 'Kinzler': [2529], 'K.W.': [2530], '1992;': [2535], '1:': [2536], '45-49Crossref': [2537], '(1728)': [2540], 'His6-tagged': [2544], 'ubiquitin': [2545], 'expressing': [2546, 2671], 'construct': [2547], 'Mittnacht.': [2555], 'vectors': [2558, 2735, 3706], 'Hdm2,': [2560], 'Hdm2ΔRING,': [2561], 'S395A,': [2563], 'S395D': [2566, 2587], 'gifts': [2569], 'Oren.': [2572], 'pCMV': [2573, 2629], 'constructed': [2576], 'S395A': [2584], '(39Maya': [2588], 'Balass': [2590], 'Kim': [2592], 'S.T.': [2593], 'Shkedy': [2594], 'Leal': [2596], 'J.F.': [2597], 'Shifman': [2598], 'O.': [2599], 'Moas': [2600], 'Buschmann': [2602], 'Shiloh': [2606], 'Kastan': [2608], 'M.B.': [2609], 'Katzir': [2610], '1067-1077Crossref': [2618], '(522)': [2621], 'Hdm2ΔRING': [2624, 3111], 'generated': [2626, 2649, 2827], 'vector': [2631], 'deletion': [2633, 3474, 3514], 'HincII-HincII': [2636], 'followed': [2638], 'religation,': [2640], 'removing': [2641, 2651], 'acids': [2643, 2655, 2676, 2745, 3478, 3489, 3517], '442–491.': [2644], 'Mdm2Δacidic': [2646], '202–303': [2656], 'Quick-Change': [2659], '(Stratagene)': [2661], 'template.': [2668], 'Myc-Mdm2-RING,': [2670], 'C-terminal': [2673], '94': [2674], '5′': [2694, 2771], 'endonuclease': [2699, 2724, 2776, 2801, 2823], 'recognition': [2700, 2725, 2777, 2802, 2824], 'sequence,': [2701, 2778], 'translation': [2703, 2780, 3625], 'initiation': [2704, 2781], 'site,': [2705, 2782], 'Myc': [2709, 2786], 'epitope': [2710, 2787], 'stop': [2719, 2796], 'codon': [2720, 2797], 'sequence.': [2726, 2803], 'Expression': [2734, 3778], 'Myc-Mdm2': [2737], 'Myc-Mdm2Δp53': [2739], '(lacking': [2740], 'N-terminal': [2742, 4069], '111': [2743], 'Mdm2)': [2747], 'To': [2811, 3681, 3712, 3750, 3985], 'generate': [2812], 'mdmx/mdm2': [2815, 2869], 'chimeric': [2816], '2X2': [2819, 2849], '22X,': [2822], '(Stratagene):': [2830], 'SspI': [2831], 'position': [2833, 2842], '106': [2834], '(Mdm2)': [2835, 2844], '105': [2837], '(Mdmx)': [2838], 'BsrGI': [2840], '303': [2843], '304': [2846], '(Mdmx).': [2847], 'consists': [2850, 2861], '(aa': [2853, 2855, 2857, 2864, 2866], '1–106)-Mdmx': [2854], '107–304)-Mdm2': [2856], '304–489),': [2858], '22X': [2860], '1–303)-Mdmx': [2865], '305–489).': [2867], 'chimeras': [2870], 'detail': [2875], 'Meulmeester': [2877], 'et': [2878, 3575, 3639], 'al.': [2879, 3576, 3640], '(40Meulmeester': [2880], 'Graaf': [2887], '4929-4938Crossref': [2900], '(96)': [2903], 'All': [2906, 4023], 'produced': [2908], 'checked': [2912], 'sequencing': [2914], 'restriction': [2916], 'analysis.': [2918], 'Luciferase': [2919, 2966, 2985, 4008], 'Assays—Transfections': [2920], 'performed': [2922, 2969, 3055, 3153, 3286, 3379, 3438, 3800, 4027], 'triplicate': [2924], 'H1299': [2926, 3989, 4212, 4307], '6-well': [2930], 'plates': [2931], '1.5': [2935], 'construct,': [2940], '60': [2941], 'ng': [2942], '1.2': [2945], 'effector': [2948], 'plasmid': [2949, 3106], '(Mdm2': [2950], 'plasmids)': [2953], '1': [2955], '300': [2960], 'μl': [2961], 'precipitate.': [2965], 'assay': [2967], 'commercial': [2972], 'kit': [2973], '(Promega),': [2974], 'measured': [2979], 'luminometer': [2982], '(Berthold,': [2983], 'Germany).': [2984], 'values': [2986, 4013], 'corrected': [2988, 4015], 'β-galactosidase': [2990, 4021], 'activity.': [2991, 4022], 'Immunoprecipitations—Cells': [2992], 'washed': [2994, 3121, 3132, 3339], 'PBS': [2996, 3342], 'lysed': [2999, 3254, 3353], 'Giordano': [3001], 'buffer': [3002], '(250': [3003], '5': [3006], 'EDTA,': [3008], '50': [3009, 3476], 'Tris-HCl,': [3011], '0.1%': [3014], 'Triton': [3015, 3144], 'X-100)': [3016], 'glycerol,': [3019], 'inhibitors.': [3023], 'concentrations': [3025], 'determined': [3031, 3975], 'Bradford': [3033], 'Reagent': [3034], '(Bio-Rad).': [3035], 'direct': [3037], 'samples': [3041], '25': [3043], 'total': [3046, 3060], 'lysate': [3047, 3061], 'separated': [3049], 'SDS-PAGE.': [3051], 'immunoprecipitations': [3053], '200': [3057], '(Babco).': [3066], 'Precipitated': [3067], 'complexes': [3068], 'blot.': [3073, 3361], 'Immunofluorescence—H1299': [3074], 'U2OS': [3076, 4234], 'cover-slips': [3081], 'transiently': [3083, 3226], 'assays': [3089], '(H1299': [3090], 'cells)': [3091], 'HA-Hdmx,': [3094], 'HA-Hdmx-A,': [3095], 'HA-Hdmx-G': [3097], 'vectors,': [3099], 'either': [3100, 3325], 'combination': [3104], '(U2OS': [3113], 'cells).': [3114], '24': [3115, 3233], 'transfection,': [3118, 3236], 'twice': [3122, 3133, 3340, 4030], 'fixed': [3125], '20': [3127, 3330], 'min': [3128], '4%': [3130], 'formaldehyde,': [3131], 'permeabilized': [3137], '10-min': [3140], 'incubation': [3141], 'X-100': [3145], 'PBS.': [3147, 3346], 'Detection': [3148], 'expressed': [3150, 4199, 4216], '4B2,': [3194], 'HA-tagged': [3196, 3775, 3855], '(anti-HA).': [3208], 'P53': [3209], 'FL393.': [3215], 'Nuclei': [3216], 'DAPI': [3220], 'staining.': [3221], 'Cycloheximide': [3222], 'Chase—H1299': [3223], 'method.': [3232], 'medium': [3238], 'replaced': [3240], 'antibiotics,': [3247], 'cycloheximide': [3249], '(50': [3250], 'μg/ml).': [3251], '0,': [3259], '1,': [3260], '2,': [3261], '4,': [3262], '6,': [3263, 3509], 'addition': [3268, 4344], 'cycloheximide.': [3270], 'Lysates': [3271], 'blotting.': [3276, 3417, 3814], 'Vivo': [3278], 'Ubiquitination': [3279], 'Assay—Purification': [3280], 'His-tagged': [3282, 3375], 'ubiquitinated': [3283], 'conjugates': [3284], 'essentially': [3287], '(14Stad': [3291, 3384], '40': [3319], 'mock-treated': [3326], 'μm': [3331], 'MG132': [3332], '4': [3334], 'h.': [3335], 'then': [3338], 'scraped': [3344], '20%': [3347], 'suspension': [3351], 'Lysis': [3362], 'remaining': [3365], '80%': [3366], 'isolation': [3373], '(ubiquitinated)': [3376], 'exactly': [3380], 'Eluates': [3412], 'Identification': [3418], 'Alternatively': [3420], 'Spliced': [3421], 'mRNAs—In': [3423], 'order': [3424], 'isolate': [3426], 'cells,': [3436, 3765, 4213, 4232], 'RT-PCR.': [3439], 'study,': [3442], 'still': [3451], 'RING,': [3454], 'hdmx-A': [3463], 'encoded': [3468], 'sequences,': [3469], 'resulting': [3470, 3510], 'inframe': [3473], '(225–274)': [3479], 'predicted': [3482], '(Fig.': [3485, 3523, 3833, 3858, 4051, 4222, 4378, 4409], '1).': [3486, 3524], 'fall': [3490], '"acidic': [3493], 'region"': [3494], 'exons': [3503], '3–5': [3504], 'part': [3506], 'in-frame': [3513], '27–124,': [3518], 'encompassing': [3519], 'Within': [3525], 'cryptic': [3529], 'splice': [3530], 'acceptor': [3531], 'site': [3532], 'present.': [3534], 'As': [3535, 3815], 'indication': [3537], 'accuracy': [3540], 'our': [3542, 4075, 4441], 'method,': [3543], 'lacking': [3550], 'sequences.': [3553], 'variant': [3556, 3674], 'homologue': [3560], 'missing': [3566], 'stretch': [3568], '68': [3570, 3611], 'nucleotides': [3571], 'Rallapalli': [3574, 3638], '(41Rallapalli': [3577, 3641], 'Strachan': [3579, 3643], 'Cho': [3581, 3645], 'Mercer': [3583, 3647], 'W.E.': [3584, 3648], 'Hall': [3585, 3649], 'D.J.': [3586, 3650], '8299-8308Abstract': [3592, 3656], '(80)': [3600, 3664], 'Like': [3603], 'mdmx,': [3605], 'contains': [3610], 'nucleotides,': [3612], 'means': [3614], 'skipping': [3616], 'results': [3619, 3636, 4421, 4442], 'frameshift': [3622], 'leading': [3623], 'termination': [3626], 'incorporation': [3628], '26': [3630], 'acids.': [3633], 'Confirming': [3634], 'Scholar),': [3666], 'efficiently': [3676], 'inhibited': [3677, 4370, 4391, 4401], 'activation.': [3680, 4059], 'study': [3682], 'Hdmx-G,': [3691, 3738, 3827], 'parts': [3693], 'cDNAs': [3696, 3722], 'recloned': [3702], 'full': [3709], 'background.': [3711], 'affinity,': [3720], 'provided': [3724], '5′-end.': [3734], 'Not': [3737], 'Can': [3739], 'Bind': [3740], 'Inhibit': [3743], 'p53-mediated': [3744, 3871, 4057, 4371, 4392, 4514], 'Transcription': [3745], '(in': [3746], 'Promoter-dependent': [3748], 'Fashion)—': [3749], 'investigate': [3751], 'high': [3767], 'endogenous': [3770, 4132], 'constructs.': [3777], 'left': [3793], 'panels': [3794], 'Fig.': [3796], '2A.': [3797], 'Immunoprecipitations': [3798], 'antibodies,': [3803], 'co-precipitate': [3808], 'expected,': [3816], 'co-immunoprecipitated': [3818], '2A,': [3834, 3859], 'right': [3835, 3860], 'bottom': [3836], 'panel).': [3837, 3862], 'Reprobing': [3838], 'same': [3840], 'stripping': [3843], 'showed': [3847, 4420], 'efficiency': [3850, 4018], 'immunoprecipitation': [3852], 'upper': [3861], 'Mdmx/Hdmx': [3864], 'reported': [3868, 4157], '11Jackson': [3914], '42Little': [3961], '4576-4580Crossref': [3968, 4450], '(55)': [3971, 4453], 'would': [3981, 4484], 'affect': [3982, 4147, 4485], 'address': [3986], 'question,': [3988], 'co-transfected': [3992], 'constructs,': [3998], 'vector,': [4003], 'bax-luciferase': [4006, 4144], 'reporter.': [4007], 'determined,': [4011], 'measuring': [4020], 'transfections': [4025], 'least': [4029], 'triplicate.': [4032], 'reduces': [4035], 'back': [4038, 4374], 'basal': [4040, 4376], '2B),': [4052], 'possibly': [4061], 'unexpected': [4062], 'because': [4063], 'fits': [4073, 4309], 'earlier': [4076, 4311], 'effect': [4125, 4347, 4356], 'mediated': [4128], 'stabilization': [4130], 'Hdm2.': [4133], 'Co-transfection': [4134], 'did': [4145], 'Mdm2-mediated': [4149, 4487], 'inhibition': [4150, 4488, 4512], 'note': [4195], 'exogenous': [4198], 'mainly': [4206], 'when': [4215], 'together': [4219], '2C),': [4223], 'contrast': [4225], 'what': [4227], 'e.g.': [4233], 'Also,': [4297], 'reports': [4312], '43Ghosh': [4328], 'Huang': [4330], 'Biochemistry.': [4334], '42:': [4336], '2291-2299Crossref': [4337], '(20)': [4340], 'bax': [4350, 4502], 'promoter,': [4351, 4503], 'studied': [4354], 'p53-dependent': [4362], 'p21': [4366, 4493], 'promoter.': [4367, 4494], 'Again,': [4368], '2D).': [4379, 4410], 'Co-expression': [4380], 'bax-luc': [4397, 4428], 'reporter,': [4398], 'Similar': [4411], 'comparable': [4422], 'those': [4424], '(results': [4430], 'shown).': [4432], 'observed': [4434], 'promoter': [4435], 'dependence': [4436], 'agreement': [4439], '(42Little': [4443], 'Saos-2': [4458], 'cells.': [4459], 'hardly': [4464], 'affected': [4465], 'investigated': [4475], 'case': [4479], 'co-transfection': [4480], 'that,': [4498], 'prevent': [4509], 'strong': [4511], 'Md': [4517]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2163552821', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-10T01:57:11.333316', 'created_date': '2016-06-24'}