Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2163369533', 'doi': 'https://doi.org/10.1101/gad.963802', 'title': 'The role of a Williams-Beuren syndrome-associated helix–loop–helix domain-containing transcription factor in activin/nodal signaling', 'display_name': 'The role of a Williams-Beuren syndrome-associated helix–loop–helix domain-containing transcription factor in activin/nodal signaling', 'publication_year': 2002, 'publication_date': '2002-04-01', 'ids': {'openalex': 'https://openalex.org/W2163369533', 'doi': 'https://doi.org/10.1101/gad.963802', 'mag': '2163369533', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11937490', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/186325'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.963802', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1101/gad.963802', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103418547', 'display_name': 'Colleen Ring', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I42570316', 'display_name': 'Japanese Foundation For Cancer Research', 'ror': 'https://ror.org/00bv64a69', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I42570316']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Colleen Ring', 'raw_affiliation_strings': ['2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA', 'institution_ids': ['https://openalex.org/I204250578']}, {'raw_affiliation_string': '2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'institution_ids': ['https://openalex.org/I42570316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015157748', 'display_name': 'Souichi Ogata', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I42570316', 'display_name': 'Japanese Foundation For Cancer Research', 'ror': 'https://ror.org/00bv64a69', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I42570316']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Souichi Ogata', 'raw_affiliation_strings': ['2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA', 'institution_ids': ['https://openalex.org/I204250578']}, {'raw_affiliation_string': '2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'institution_ids': ['https://openalex.org/I42570316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036990907', 'display_name': 'Lauren M. Meek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}, {'id': 'https://openalex.org/I42570316', 'display_name': 'Japanese Foundation For Cancer Research', 'ror': 'https://ror.org/00bv64a69', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I42570316']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Lauren Meek', 'raw_affiliation_strings': ['2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA', 'institution_ids': ['https://openalex.org/I204250578']}, {'raw_affiliation_string': '2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'institution_ids': ['https://openalex.org/I42570316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013799594', 'display_name': 'Jihwan Song', 'orcid': 'https://orcid.org/0000-0002-6597-8208'}, 'institutions': [{'id': 'https://openalex.org/I42570316', 'display_name': 'Japanese Foundation For Cancer Research', 'ror': 'https://ror.org/00bv64a69', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I42570316']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jihwan Song', 'raw_affiliation_strings': ['2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA'], 'affiliations': [{'raw_affiliation_string': '2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'institution_ids': ['https://openalex.org/I42570316']}, {'raw_affiliation_string': 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017148137', 'display_name': 'Tatsuru Ohta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42570316', 'display_name': 'Japanese Foundation For Cancer Research', 'ror': 'https://ror.org/00bv64a69', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I42570316']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Tatsuru Ohta', 'raw_affiliation_strings': ['2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA'], 'affiliations': [{'raw_affiliation_string': '2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'institution_ids': ['https://openalex.org/I42570316']}, {'raw_affiliation_string': 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051009186', 'display_name': 'Kohei Miyazono', 'orcid': 'https://orcid.org/0000-0001-7341-0172'}, 'institutions': [{'id': 'https://openalex.org/I42570316', 'display_name': 'Japanese Foundation For Cancer Research', 'ror': 'https://ror.org/00bv64a69', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I42570316']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Kohei Miyazono', 'raw_affiliation_strings': ['2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA'], 'affiliations': [{'raw_affiliation_string': '2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'institution_ids': ['https://openalex.org/I42570316']}, {'raw_affiliation_string': 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074829260', 'display_name': 'Ken W.Y. Cho', 'orcid': 'https://orcid.org/0000-0001-7282-1770'}, 'institutions': [{'id': 'https://openalex.org/I42570316', 'display_name': 'Japanese Foundation For Cancer Research', 'ror': 'https://ror.org/00bv64a69', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I42570316']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Ken W.Y. Cho', 'raw_affiliation_strings': ['2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA'], 'affiliations': [{'raw_affiliation_string': '2Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR) Toshima-ku, Tokyo 170–8455,\n Japan', 'institution_ids': ['https://openalex.org/I42570316']}, {'raw_affiliation_string': 'Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California\n 92697-2300, USA', 'institution_ids': ['https://openalex.org/I204250578']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.891, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 48, 'citation_normalized_percentile': {'value': 0.838419, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '16', 'issue': '7', 'first_page': '820', 'last_page': '835'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11677', 'display_name': 'Congenital heart defects research', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11677', 'display_name': 'Congenital heart defects research', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13258', 'display_name': 'Williams Syndrome Research', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9882, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nodal-signaling', 'display_name': 'Nodal signaling', 'score': 0.86392343}, {'id': 'https://openalex.org/keywords/acvr2b', 'display_name': 'ACVR2B', 'score': 0.6130402}, {'id': 'https://openalex.org/keywords/activin-receptor', 'display_name': 'Activin receptor', 'score': 0.53454465}, {'id': 'https://openalex.org/keywords/transcription-preinitiation-complex', 'display_name': 'Transcription preinitiation complex', 'score': 0.529055}], 'concepts': [{'id': 'https://openalex.org/C83330619', 'wikidata': 'https://www.wikidata.org/wiki/Q21124872', 'display_name': 'NODAL', 'level': 2, 'score': 0.8760818}, {'id': 'https://openalex.org/C38643226', 'wikidata': 'https://www.wikidata.org/wiki/Q4677604', 'display_name': 'Activin type 2 receptors', 'level': 4, 'score': 0.86872745}, {'id': 'https://openalex.org/C205583638', 'wikidata': 'https://www.wikidata.org/wiki/Q7046607', 'display_name': 'Nodal signaling', 'level': 5, 'score': 0.86392343}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.835867}, {'id': 'https://openalex.org/C2779535977', 'wikidata': 'https://www.wikidata.org/wiki/Q1342298', 'display_name': 'Xenopus', 'level': 3, 'score': 0.67611283}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.65570384}, {'id': 'https://openalex.org/C22517002', 'wikidata': 'https://www.wikidata.org/wiki/Q14905179', 'display_name': 'ACVR2B', 'level': 4, 'score': 0.6130402}, {'id': 'https://openalex.org/C2778649528', 'wikidata': 'https://www.wikidata.org/wiki/Q4677603', 'display_name': 'Activin receptor', 'level': 3, 'score': 0.53454465}, {'id': 'https://openalex.org/C188740287', 'wikidata': 'https://www.wikidata.org/wiki/Q423333', 'display_name': 'Transcription preinitiation complex', 'level': 5, 'score': 0.529055}, {'id': 'https://openalex.org/C111001777', 'wikidata': 'https://www.wikidata.org/wiki/Q3562192', 'display_name': 'TGF beta signaling pathway', 'level': 3, 'score': 0.48425767}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46698803}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.41309816}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.33624935}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.31073606}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.30361724}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.13987294}, {'id': 'https://openalex.org/C129536746', 'wikidata': 'https://www.wikidata.org/wiki/Q1141026', 'display_name': 'Gastrulation', 'level': 4, 'score': 0.11707464}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.092148155}], 'mesh': [{'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018980', 'descriptor_name': 'Williams Syndrome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D029867', 'descriptor_name': 'Xenopus Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D029867', 'descriptor_name': 'Xenopus Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D028341', 'descriptor_name': 'Activins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D028341', 'descriptor_name': 'Activins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051792', 'descriptor_name': 'Basic Helix-Loop-Helix Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018257', 'descriptor_name': 'Helix-Loop-Helix Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051899', 'descriptor_name': 'Smad2 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018980', 'descriptor_name': 'Williams Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014981', 'descriptor_name': 'Xenopus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029867', 'descriptor_name': 'Xenopus Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.963802', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc186325', 'pdf_url': 'https://europepmc.org/articles/pmc186325?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186325', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11937490', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.963802', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1515719112', 'https://openalex.org/W1663371441', 'https://openalex.org/W1744684896', 'https://openalex.org/W1846721807', 'https://openalex.org/W1858153082', 'https://openalex.org/W1897269170', 'https://openalex.org/W1923939500', 'https://openalex.org/W1966300079', 'https://openalex.org/W1967703786', 'https://openalex.org/W1974053426', 'https://openalex.org/W1978411854', 'https://openalex.org/W1979647722', 'https://openalex.org/W1985929046', 'https://openalex.org/W1993154580', 'https://openalex.org/W2001642012', 'https://openalex.org/W2005494875', 'https://openalex.org/W2014371162', 'https://openalex.org/W2023077752', 'https://openalex.org/W2026428548', 'https://openalex.org/W2030071077', 'https://openalex.org/W2040584895', 'https://openalex.org/W2043377295', 'https://openalex.org/W2047102823', 'https://openalex.org/W2056348354', 'https://openalex.org/W2059437327', 'https://openalex.org/W2068224181', 'https://openalex.org/W2070539534', 'https://openalex.org/W2071135527', 'https://openalex.org/W2071230707', 'https://openalex.org/W2090494599', 'https://openalex.org/W2091087816', 'https://openalex.org/W2091821419', 'https://openalex.org/W2098395709', 'https://openalex.org/W2099173483', 'https://openalex.org/W2102144828', 'https://openalex.org/W2103256978', 'https://openalex.org/W2105884976', 'https://openalex.org/W2107942632', 'https://openalex.org/W2109379227', 'https://openalex.org/W2112406299', 'https://openalex.org/W2112909601', 'https://openalex.org/W2113397827', 'https://openalex.org/W2116428404', 'https://openalex.org/W2117526699', 'https://openalex.org/W2120643964', 'https://openalex.org/W2127202275', 'https://openalex.org/W2136190597', 'https://openalex.org/W2141150300', 'https://openalex.org/W2148514691', 'https://openalex.org/W2149190378', 'https://openalex.org/W2163107788', 'https://openalex.org/W2187553747', 'https://openalex.org/W2208796000', 'https://openalex.org/W4296588288'], 'related_works': ['https://openalex.org/W4238330851', 'https://openalex.org/W2601362945', 'https://openalex.org/W2154564110', 'https://openalex.org/W2131037997', 'https://openalex.org/W2117975612', 'https://openalex.org/W2103256978', 'https://openalex.org/W2020288215', 'https://openalex.org/W1999253696', 'https://openalex.org/W1977151351', 'https://openalex.org/W119865239'], 'abstract_inverted_index': {'We': [0, 71], 'investigated': [1], 'the': [2, 5, 11, 19, 25, 33, 86, 94, 124], 'regulation': [3], 'of': [4, 10, 21, 32, 88, 96, 108, 113, 127], 'activin/nodal-inducible': [6, 114], 'distal': [7], 'element': [8], '(DE)': [9], 'Xenopus': [12, 30], 'goosecoid': [13], '(': [14], 'gsc': [15, 98], ')': [16], 'promoter.': [17], 'On': [18], 'basis': [20], 'its': [22], 'interaction': [23], 'with': [24, 47, 64, 80], 'DE,': [26], 'we': [27, 57], 'isolated': [28], 'a': [29, 53, 73, 83, 111], 'homolog': [31], 'human': [34], 'Williams-Beuren': [35], 'syndrome': [36], 'critical': [37], 'region': [38], '11': [39], '(XWBSCR11),': [40], 'and': [41, 50], 'further,': [42], 'show': [43], 'that': [44, 60], 'it': [45], 'interacts': [46], 'pathway-specific': [48], 'Smad2': [49], 'Smad3': [51], 'in': [52, 75, 93, 118], 'ligand-dependent': [54], 'manner.': [55], 'Interestingly,': [56], 'also': [58], 'find': [59], 'XWBSCR11': [61, 92], 'functions': [62, 78], 'cooperatively': [63], 'FoxH1': [65, 77], '(Fast-1)': [66], 'to': [67, 123], 'stimulate': [68], 'DE-dependent': [69], 'transcription.': [70], 'propose': [72], 'mechanism': [74, 102], 'which': [76], 'together': [79], 'Smads': [81], 'as': [82], 'cofactor': [84], 'for': [85, 106], 'recruitment': [87], 'transcription': [89, 109], 'factors': [90], 'like': [91], 'process': [95], 'activin/nodal-mediated': [97], '-specific': [99], 'induction.': [100], 'This': [101], 'provides': [103], 'considerable': [104], 'opportunities': [105], 'modulation': [107], 'across': [110], 'variety': [112], 'genes,': [115], 'increasing': [116], 'diversity': [117], 'promoter': [119], 'selection,': [120], 'thus': [121], 'leading': [122], 'differential': [125], 'induction': [126], 'activin/nodal': [128], 'target': [129], 'genes.': [130]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2163369533', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-22T14:11:53.892733', 'created_date': '2016-06-24'}