Elevated Synaptic Activity Preconditions Neurons against an in Vitro Model of Ischemia

Name: Work Video:
Duration: 3 min 30 s
Joseph S. Tauskela; Hung Fang; Melissa Hewitt; Eric Brunette; Tarun Ahuja; Jean‐Philippe Thivierge; Tanya Comas; Geoffrey Mealing
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'https://openalex.org/W1534743471'], 'abstract_inverted_index': {'Tolerance': [0, 245, 3808], 'to': [1, 9, 22, 41, 67, 75, 80, 103, 109, 188, 246, 254, 267, 286, 312, 320, 325, 348, 354, 433, 500, 532, 540, 621, 632, 641, 893, 904, 909, 938, 1003, 1096, 1112, 1261, 1264, 1276, 1305, 1314, 1318, 1636, 1865, 1930, 2027, 2075, 2085, 2092, 2205, 2313, 2398, 2520, 2577, 2612, 2628, 2636, 2651, 2662, 2669, 2784, 2830, 2854, 2909, 2916, 2958, 3037, 3080, 3355, 3365, 3388, 3479, 3501, 3550, 3567, 3586, 3656, 3668, 3694, 3739, 3742, 3809, 3826, 3880, 4005, 4068, 4073, 4081, 4130, 4213], 'otherwise': [2, 247, 622, 3356], 'lethal': [3, 105, 248, 350, 623, 3357, 3707, 3743], 'cerebral': [4, 249], 'ischemia': [5, 250, 534, 642, 676, 910, 995, 1097, 1136], 'in': [6, 13, 27, 70, 100, 182, 225, 237, 251, 258, 272, 315, 345, 427, 470, 482, 535, 612, 615, 1132, 1266, 1269, 1302, 1321, 1498, 1590, 1634, 1641, 1826, 1868, 1954, 1960, 2209, 2453, 2466, 2505, 2644, 2655, 2688, 2695, 2814, 3050, 3207, 3273, 3314, 3350, 3399, 3410, 3443, 3462, 3590, 3621, 3636, 4062, 4229], 'vivo': [7, 252, 536, 4230], 'or': [8, 136, 168, 253, 381, 413, 537, 635, 677, 897, 937, 997, 1098, 1187, 1192, 1292, 1311, 1317, 1326, 1675, 1878, 2083, 2298, 2463, 2499, 2556, 3238, 3727, 3745, 4150, 4198], 'oxygen-glucose': [10, 255, 551], 'deprivation': [11, 256, 544, 1310], '(OGD)': [12, 257, 545], 'vitro': [14, 259, 1827], 'can': [15, 37, 260, 282, 497, 525, 626, 999, 1174, 1607, 3287, 3930], 'be': [16, 53, 261, 298, 498, 526, 628, 1106, 1130, 1220, 3288, 3806, 3878, 3931], 'induced': [17, 73, 114, 262, 318, 359, 1307, 1320, 1592, 1625, 3353, 3515, 3734, 4071, 4128], 'by': [18, 55, 130, 263, 300, 375, 505, 528, 630, 675, 993, 1100, 1165, 1273, 1293, 1308, 1312, 1501, 1593, 1882, 1922, 2046, 2302, 2443, 2591, 2709, 2950, 2961, 2987, 3002, 3055, 3092, 3114, 3155, 3197, 3233, 3290, 3302, 3379, 3454, 3494, 3516, 3556, 3648, 3735, 3749, 3898, 3960, 3996, 4189, 4221, 4225], 'prior': [19, 264], 'transient': [20, 265, 533, 890, 994], 'exposure': [21, 266, 631, 892, 1313, 2742, 3478, 3566, 4004], 'N-methyl-d-aspartic': [23, 268, 589], 'acid': [24, 269, 4227], '(NMDA):': [25, 270], 'preconditioning': [26, 144, 271, 389, 510, 674, 990, 1071, 1104, 1133, 1640, 1858, 2288, 3493, 3716, 3751, 3895, 3906, 4091, 4158, 4176], 'this': [28, 49, 273, 294, 2843, 3351, 3798, 3827], 'manner': [29, 274, 1643, 3352], 'activates': [30, 275], 'extrasynaptic': [31, 276, 1193, 1226, 1603], 'and': [32, 36, 87, 118, 125, 151, 153, 177, 222, 230, 232, 277, 281, 332, 363, 370, 396, 398, 422, 467, 475, 477, 542, 618, 1323, 1429, 1491, 1513, 1611, 1664, 1747, 1782, 1794, 1884, 2234, 2294, 2311, 2336, 2346, 2359, 2395, 2432, 2486, 2501, 2575, 2692, 2719, 2782, 2805, 2808, 2881, 2901, 2914, 2924, 2991, 3062, 3099, 3122, 3137, 3186, 3210, 3217, 3301, 3320, 3369, 3381, 3386, 3404, 3408, 3426, 3467, 3481, 3562, 3569, 3792, 3822, 3917, 3963, 4210, 4237], 'synaptic': [33, 60, 219, 278, 305, 464, 1191, 1199, 1205, 1257, 1487, 1507, 1627, 1651, 3285, 3321], 'NMDA': [34, 61, 134, 220, 279, 306, 379, 465, 668, 898, 998, 1128, 1181, 1194, 1200, 1227, 1488, 1508, 1604, 1628, 2088, 3728, 3746, 4025, 4136, 4208], 'receptors': [35, 135, 221, 280, 380, 466, 1129, 1182, 1228, 1509, 3729, 3929, 4137, 4152, 4209, 4236], 'require': [38, 283, 1000], 'bringing': [39, 284, 1001], 'neurons': [40, 66, 201, 285, 311, 446, 539, 1002, 1110, 1134, 1275, 1624, 1812, 2095, 3655, 3667], 'the': [42, 56, 162, 209, 287, 301, 407, 454, 495, 530, 667, 1004, 1113, 1139, 1150, 1157, 1178, 1209, 1524, 1586, 1937, 2489, 2584, 2739, 2834, 2839, 2855, 2893, 2898, 2952, 2963, 2976, 2989, 2998, 3004, 3009, 3022, 3034, 3039, 3046, 3058, 3065, 3068, 3077, 3094, 3116, 3119, 3123, 3132, 3140, 3183, 3208, 3215, 3225, 3239, 3248, 3295, 3393, 3486, 3558, 3563, 3682, 3873, 3911, 3997, 4024, 4082, 4214], '"brink': [43, 288, 1005], 'of': [44, 58, 116, 133, 149, 217, 228, 234, 289, 303, 361, 378, 394, 462, 473, 479, 610, 666, 670, 1006, 1092, 1102, 1109, 1152, 1159, 1180, 1211, 1214, 1225, 1298, 1486, 1493, 1506, 1515, 1523, 1588, 1621, 1658, 1806, 1808, 1856, 1969, 2048, 2223, 2226, 2245, 2262, 2268, 2273, 2287, 2291, 2374, 2587, 2594, 2610, 2618, 2626, 2833, 2866, 2871, 2886, 2927, 2936, 2955, 2994, 3011, 3088, 3110, 3134, 3143, 3188, 3212, 3235, 3297, 3323, 3395, 3401, 3469, 3488, 3504, 3547, 3560, 3565, 3579, 3605, 3624, 3688, 3692, 3702, 3725, 3797, 3891, 3987, 3999, 4023, 4084, 4089, 4167, 4207, 4216, 4233], 'death."': [45, 290], 'We': [46, 291, 1616], 'considered': [47, 292, 1617], 'if': [48, 293, 1255, 1618, 3202, 3346, 3802], 'stressful': [50, 295], 'requirement': [51, 296, 1213, 3683], 'could': [52, 297, 3805], 'minimized': [54, 299], 'stimulation': [57, 302], 'primarily': [59, 218, 304, 463], 'receptors.': [62, 307], 'Subjecting': [63, 308], 'cultured': [64, 202, 309, 447, 538, 1622], 'cortical': [65, 310, 1623, 1811, 1927, 3360], 'prolonged': [68, 240, 313, 485, 1511], 'elevations': [69, 314], 'electrical': [71, 316, 1270, 1502, 1594, 3505], 'activity': [72, 317, 1595, 2928, 3286, 3348, 4224], 'tolerance': [74, 102, 155, 319, 347, 400, 620, 1263, 1301, 1635, 3354, 3446, 3553, 3626, 3678, 3697, 3741, 3804, 3825, 3958, 4072, 4129, 4162, 4187], 'OGD.': [76, 321, 3391, 4131], 'Specifically,': [77, 322], 'exposing': [78, 323, 1274, 4066], 'cultures': [79, 324, 1822, 1928, 2024, 2077, 2116, 2635, 2666, 3362, 4067], 'a': [81, 88, 238, 326, 333, 483, 506, 1065, 1093, 1107, 1116, 1147, 1216, 1277, 1285, 1626, 1642, 1656, 1778, 1931, 1955, 1988, 2153, 2164, 2182, 2194, 2239, 2242, 2260, 2266, 2379, 2521, 2616, 2745, 2787, 2823, 2860, 2890, 2904, 2917, 3074, 3081, 3105, 3135, 3144, 3157, 3265, 3305, 3382, 3521, 3617, 3632, 3685, 3706, 3902, 4056, 4063, 4090, 4133], 'K+-channel': [82, 327], 'blocker,': [83, 328, 1288, 3954], '4-aminopyridine': [84, 329, 1289, 3291], '(20–2500': [85, 330], 'μm),': [86, 331], 'GABAA': [89, 334, 1278, 3306], 'receptor': [90, 335, 672, 1195, 1201, 1279, 1605, 3307, 3747, 3903, 4026], 'antagonist,': [91, 336, 1280, 3308, 4059], 'bicuculline': [92, 337, 3303, 3370, 3495], '(50': [93, 338, 2318, 3371], 'μm)': [94, 339, 3372, 4002], '(4-AP/bic),': [95, 340], 'for': [96, 186, 341, 431, 664, 1142, 2039, 2089, 2112, 2231, 2236, 2248, 2356, 2365, 2426, 2434, 2482, 2497, 2503, 2532, 2647, 2658, 2674, 2702, 2729, 2759, 2911, 2934, 3029, 3045, 3104, 3167, 3190, 3253, 3375, 3524, 3627, 3641, 3670, 3684, 3974, 3985, 4121, 4135, 4193], '1–2': [97, 342], 'days': [98, 111, 190, 343, 356, 435, 1825], 'resulted': [99, 181, 344, 426, 3398, 3620, 3635], 'potent': [101, 346, 907], 'normally': [104, 349], 'OGD': [106, 126, 154, 178, 351, 371, 399, 423, 678, 939, 996, 1099, 1265, 1890, 3282, 3397, 3412, 3445, 3552, 3596, 3625, 3640, 3659, 3677, 3696, 3908, 3957, 3988, 3992, 4075, 4161, 4186, 4217], 'applied': [107, 142, 352, 387, 2878, 3028, 3269], 'up': [108, 187, 353, 432], '3': [110, 189, 355, 434, 2032, 2480, 2847], 'later.': [112, 357], 'Preconditioning': [113, 180, 358, 425, 524, 3280, 4219], 'phosphorylation': [115, 148, 227, 360, 393, 472, 1492, 1512, 1613], 'ERK1/2': [117, 150, 167, 229, 362, 395, 412, 474, 567, 1589, 1610, 2296], 'CREB': [119, 231, 364, 476, 574, 1494, 1612, 2292, 2451, 2500, 2686], 'which,': [120, 365], 'along': [121, 366], 'with': [122, 213, 367, 458, 1068, 1185, 1190, 1204, 1223, 1284, 1295, 1646, 1650, 1655, 1818, 1886, 1984, 2035, 2119, 2181, 2190, 2238, 2241, 2307, 2411, 2448, 2538, 2544, 2565, 2622, 2684, 2711, 2798, 2802, 2811, 3164, 3485, 3510, 3598, 4148, 4153, 4181], 'Ca2+': [123, 139, 146, 175, 368, 384, 391, 420, 564, 2099, 2103, 2274, 3318, 3452, 3458, 3471, 3513, 3527, 4145], 'spiking': [124, 176, 369, 421, 3319, 3453, 3514, 3528], 'tolerance,': [127, 372, 3597], 'was': [128, 373, 1694, 1704, 1715, 1723, 1731, 1863, 1891, 1973, 2073, 2150, 2229, 2300, 2376, 2441, 2515, 2632, 2766, 2796, 2845, 2895, 2929, 3027, 3042, 3152, 3194, 3251, 3258, 3268, 3424, 3429, 3437, 3482, 3554, 3614, 3660, 3815, 3835, 3968, 3983, 3993, 4138], 'eliminated': [129, 374, 3512], 'tetrodotoxin.': [131, 376], 'Antagonists': [132, 377], 'l-type': [137, 382, 4143], 'voltage-gated': [138, 383, 563, 4144], 'channels': [140, 385, 2938, 3103, 3509, 4239], '(L-VGCCs)': [141, 386, 4147], 'during': [143, 388, 673, 3658, 3811, 3894, 3905, 4003, 4027, 4155], 'decreased': [145, 390], 'spiking,': [147, 392, 2104], 'CREB,': [152, 397, 569], 'more': [156, 401, 1221, 1644, 4183], 'effectively': [157, 402, 4184], 'when': [158, 403, 3064], 'combined,': [159, 404], 'particularly': [160, 405], 'at': [161, 406, 2042, 2348, 2361, 2368, 2429, 2437, 2535, 2677, 2705, 2732, 2931, 3147, 3200, 3260, 3698, 3933], 'lowest': [163, 408, 3918], '4-AP': [164, 409, 3366, 3489, 3580, 3643, 3693, 3923, 3935], 'concentration.': [165, 410, 3644], 'Inhibiting': [166, 411], 'Ca2+/calmodulin-dependent': [169, 414, 556], 'protein': [170, 415, 557, 577, 602, 1526, 1792, 2372, 2382, 2671], 'kinases': [171, 416], '(CaMKs)': [172, 417], 'also': [173, 418, 627, 905], 'reduced': [174, 419], 'tolerance.': [179, 424, 3989, 4218], 'altered': [183, 428], 'neuronal': [184, 429, 1303, 1647, 2283, 3298, 3402, 3422, 3456, 3720, 3732], 'excitability': [185, 430], 'following': [191, 436, 1938, 1977, 3572, 3611], '4-AP/bic': [192, 437, 1619, 1871, 1875, 2232, 2237, 3279, 3442, 3517, 3568, 3573, 3591, 3612, 3629, 3650, 3657, 3669, 3750, 3812, 3832, 3965, 4014, 4127, 4157, 4175, 4202], 'washout,': [193, 438, 3653], 'based': [194, 439], 'on': [195, 203, 440, 448, 901, 1177, 1183, 1821, 2289, 2634, 2751, 2827, 3418, 3971, 4173], 'field': [196, 441], 'potential': [197, 442, 4030], 'recordings': [198, 443], 'obtained': [199, 444, 1705, 3091, 3113], 'from': [200, 445, 1668, 1685, 1696, 1706, 1717, 1725, 1733, 1751, 1788, 1800, 2051, 2115, 2259, 2265, 2281, 2615, 2736, 2897, 3008, 3073, 3582], '64-channel': [204, 449], 'multielectrode': [205, 450, 586, 2788], 'arrays.': [206, 451], 'Taken': [207, 452], 'together,': [208, 453], 'data': [210, 455, 3711], 'are': [211, 456, 1521, 2608, 3222], 'consistent': [212, 457], 'action': [214, 459, 3299, 3315, 3979, 4029], 'potential-driven': [215, 460], 'co-activation': [216, 461, 4206], 'L-VGCCs,': [223, 468, 561], 'resulting': [224, 469, 614, 3313], 'parallel': [226, 471], 'involvement': [233, 478], 'CaMKs,': [235, 480], 'culminating': [236, 481], 'potent,': [239, 484, 617], 'but': [241, 486, 2837, 3784, 3824, 4009, 4165], 'reversible,': [242, 487], 'OGD-tolerant': [243, 488], 'phenotype.': [244, 489], 'It': [490], 'is': [491, 679, 853, 899, 1125, 1163, 1259, 1496, 3139], 'well': [492, 680, 1155, 1168, 2056], 'established': [493, 681, 4139], 'that': [494, 638, 1118, 1218, 2078, 3715, 4205], 'brain': [496, 531], 'prepared': [499, 1814], 'withstand': [501], 'an': [502, 1609, 1961, 2566, 2769, 2828, 2863, 2869, 2882, 3602, 3975, 4028], 'ischemic': [503], 'insult': [504], 'process': [507, 1148], 'known': [508], 'as': [509, 1154, 1156, 1169, 1815, 1893, 1979, 2216, 2744, 2974, 3224, 3326, 3439, 3441], '(1.Kirino': [511, 940, 1008], 'T.': [512, 646, 687, 722, 730, 736, 770, 941, 968, 1009, 1024, 1076, 1232, 1837, 1905, 2006, 2132, 4105], 'J.': [513, 711, 741, 753, 843, 921, 942, 957, 974, 1010, 1030, 1238, 1355, 1375, 1397, 1454, 1533, 1558, 1845, 1913, 2014, 2140, 4045, 4101, 4108, 4248], 'Cereb.': [514, 943, 1011, 4249], 'Blood': [515, 944, 1012, 4250], 'Flow': [516, 945, 1013, 4251], 'Metab.': [517, 946, 1014, 4252], '2002;': [518, 825, 947, 1015, 1337, 1535, 3537, 3848], '22:': [519, 948, 1016], '1283-1296Crossref': [520, 949, 1017], 'PubMed': [521, 695, 716, 746, 758, 782, 813, 828, 848, 871, 884, 932, 950, 962, 983, 1018, 1039, 1060, 1247, 1340, 1360, 1380, 1402, 1418, 1480, 1538, 1563, 1580, 1849, 1917, 2018, 2144, 3339, 3540, 3763, 3779, 3851, 3867, 3946, 4050, 4113], 'Google': [522, 698, 719, 747, 759, 785, 816, 831, 849, 874, 887, 935, 951, 963, 986, 1019, 1042, 1063, 1250, 1343, 1363, 1383, 1405, 1421, 1483, 1541, 1566, 1583, 1852, 1920, 2021, 2147, 3342, 3543, 3766, 3782, 3854, 3870, 3949, 4051, 4114], 'Scholar).': [523, 660, 888, 987, 1090, 1251, 1484, 1853, 2022, 2148, 3343, 3544, 3871, 3950, 4115], 'achieved': [527, 991, 1272], 'subjecting': [529, 3654], 'oxygen': [541], 'glucose': [543, 2034], '2The': [546], 'abbreviations': [547], 'used': [548, 3036], 'are:': [549], 'OGD,': [550, 1637, 3358, 3736], 'deprivation;': [552], '4-AP/bic,': [553], '4-aminopyridine/bicuculline;': [554], 'CaMK,': [555], 'kinase;': [558, 599, 604], '8-CPT,': [559], '8-cyclopenthyltheophylline;': [560], 'L-type': [562], 'channels;': [565], 'pERK1/2,': [566], 'phosphorylation;': [568, 575], 'cAMP-response': [570], 'element-binding': [571], 'protein;': [572], 'pCREB,': [573], 'PKA,': [576], 'kinase': [578, 1527], 'A;': [579, 595], 'PI,': [580, 1983], 'propidium': [581, 1763], 'iodide;': [582], 'TTX,': [583, 3955], 'tetrodotoxin;': [584], 'MEA,': [585, 3182], 'array;': [587], 'NMDA,': [588, 1299], 'acid;': [590], 'GABAA,': [591], 'γ-aminobutyric': [592], 'acid,': [593, 1740], 'type': [594, 669], 'ERK,': [596], 'extracellular': [597, 1516], 'signal-regulated': [598, 1517], 'MEK,': [600], 'mitogen-activated': [601, 1525], 'kinase/ERK': [603], 'MK-801,': [605], '(5S,10R)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine': [606, 1743], 'maleate;': [607], 'ANOVA,': [608], 'analysis': [609, 3234], 'variance.': [611], 'vitro,': [613], 'delayed,': [616], 'reversible': [619], 'ischemia/OGD.': [624], 'Neurons': [625], 'preconditioned': [629, 3419], 'numerous': [633], 'environmental': [634], 'chemical': [636, 1315], 'stimuli': [637], 'generate': [639], '"cross-tolerance"': [640], '(2.Tauskela': [643, 1073], 'J.S.': [644, 762, 966, 1022, 1074, 1230, 1829, 1897, 1998, 2124], 'Gendron': [645, 1075, 1838, 1906, 2007, 2133], 'Morley': [647, 775, 977, 1033, 1077, 1241, 1842, 1910, 2011, 2137, 4102], 'P.': [648, 776, 978, 1034, 1078, 1242, 1348, 1464, 1843, 1911, 2012, 2138, 4103], 'Schaller': [649, 1079], 'B.': [650, 912, 1080, 1366, 4097], 'Cerebral': [651, 1081], 'Ischemic': [652, 1082], 'Tolerance.': [653, 1083], 'Nova': [654, 1084], 'Science': [655, 1085, 2404], 'Publishers,': [656, 1086], 'Inc.,': [657, 1087, 2552, 2603], 'Hauppauge2004:': [658, 1088], '45-94Google': [659, 1089], 'A': [661, 2221, 3791, 3821, 3951], 'key': [662], 'role': [663, 1587, 3523, 4134], 'activation': [665, 1202, 1224, 1490, 1505, 1514, 1606, 3724, 3748, 4022, 4232], 'glutamate': [671, 896, 3327, 3726, 3744], '(3.Kato': [682], 'H.': [683, 1334, 1352, 1394, 1412, 3534, 3757, 3773, 3845, 3861, 4241], 'Liu': [684], 'Y.': [685, 768, 1332, 1552, 1555, 3532, 3843], 'Araki': [686], 'Kogure': [688], 'K.': [689, 724, 726, 728, 970, 1026, 1234, 1374, 1466, 4099], 'Neurosci.': [690, 742, 754, 844, 958, 1051, 1336, 1356, 1376, 1398, 1414, 1476, 3536, 3759, 3775, 3847, 3863, 4046, 4109], 'Lett.': [691], '1992;': [692, 4047], '139:': [693], '118-121Crossref': [694], 'Scopus': [696, 717, 783, 814, 829, 872, 885, 933, 984, 1040, 1061, 1248, 1341, 1361, 1381, 1403, 1419, 1481, 1539, 1564, 1581, 1850, 1918, 2019, 2145, 3340, 3541, 3764, 3780, 3852, 3868, 3947], '(142)': [697], 'Scholar,': [699, 720, 748, 760, 786, 817, 832, 875, 952, 964, 1020, 1043, 1344, 1364, 1384, 1406, 1422, 1436, 1542, 1567, 3767, 3855], '4.Bond': [700], 'A.': [701, 774, 809, 861, 1450, 1544], 'Lodge': [702], 'D.': [703, 734, 838, 1427], 'Hicks': [704], 'C.A.': [705], 'Ward': [706], 'M.A.': [707, 842, 1444, 3938], "O'Neill": [708], 'M.J.': [709], 'Eur.': [710], 'Pharmacol.': [712], '1999;': [713, 755, 779, 959, 3336, 4253], '380:': [714], '91-99Crossref': [715], '(100)': [718], '5.Mabuchi': [721], 'Kitagawa': [723], 'Kuwabara': [725], 'Takasawa': [727], 'Ohtsuki': [729], 'Xia': [731], 'Z.': [732], 'Storm': [733], 'Yanagihara': [735], 'Hori': [737], 'M.': [738, 740, 772, 788, 857, 976, 1032, 1240, 1424, 1452, 1460, 4247], 'Matsumoto': [739], '2001;': [743, 980, 1036, 1244, 3776], '21:': [744], '9204-9213Crossref': [745], '6.Grabb': [749, 953], 'M.C.': [750, 954], 'Choi': [751, 955], 'D.W.': [752, 956], '19:': [756, 960, 1847, 1915, 2016, 2142], '1657-1662Crossref': [757, 961], '7.Tauskela': [761], 'Chakravarthy': [763, 4096], 'B.R.': [764], 'Murray': [765], 'C.L.': [766], 'Wang': [767], 'Comas': [769, 967, 1023, 1231, 1836, 1904, 2005, 2131], 'Hogan': [771, 975, 1031, 1239], 'Hakim': [773], 'Brain': [777, 3941], 'Res.': [778, 867, 3942], '827:': [780], '143-151Crossref': [781], '(54)': [784], '8.Gonzalez-Zulueta': [787], 'Feldman': [789], 'A.B.': [790], 'Klesse': [791], 'L.J.': [792, 1532, 1575], 'Kalb': [793], 'R.G.': [794], 'Dillman': [795], 'J.F.': [796], 'Parada': [797], 'L.F.': [798], 'Dawson': [799, 801], 'T.M.': [800], 'V.L.': [802], 'Proc.': [803], 'Natl.': [804], 'Acad.': [805], 'Sci.': [806], 'U.': [807, 1045], 'S.': [808, 1346, 1372, 1388, 1438, 1548, 4040], '2000;': [810, 4110], '97:': [811], '436-441Crossref': [812], '(302)': [815], '9.Semenov': [818], 'D.G.': [819], 'Samoilov': [820], 'M.O.': [821], 'Lazarewicz': [822, 864], 'J.W.': [823, 865, 4034], 'Neurosignals.': [824], '11:': [826, 1478], '329-335Crossref': [827], '(25)': [830], '10.Raval': [833], 'A.P.': [834], 'Dave': [835], 'K.R.': [836, 1370], 'Mochly-Rosen': [837], 'Sick': [839], 'T.J.': [840], 'Perez-Pinzon': [841], '2003;': [845, 1052], '23:': [846], '384-391Crossref': [847], 'Scholar),': [850, 1064, 1584, 3783, 4052], 'although': [851, 1585], 'agreement': [852], 'not': [854, 1597, 2838, 3414, 3438, 3448, 3661, 3664, 3675, 3712, 3718, 3786, 3816, 4010, 4018, 4125], 'complete': [855], '(11.Duszczyk': [856], 'Gadamski': [858], 'R.': [859, 972, 1028, 1236, 1462, 1841, 1909, 2010, 2136, 3329, 4095], 'Ziembowicz': [860], 'Danysz': [862], 'W.': [863], 'Neurotox.': [866], '2005;': [868, 924, 1357, 1377, 1846, 1914, 2015, 2141], '7:': [869], '283-292Crossref': [870], '(19)': [873], '12.Wrang': [876], 'M.L.': [877], 'Diemer': [878], 'N.H.': [879], 'Neuroreport.': [880], '2004;': [881], '15:': [882], '1151-1155Crossref': [883], '(7)': [886], 'Moreover,': [889], 'non-lethal': [891], 'high': [894, 3962, 4011, 4174, 4195], 'dose': [895], 'sufficient': [900, 1260], 'its': [902, 2217, 3972], 'own': [903, 2218, 3973], 'induce': [906, 1262, 1300, 1608, 3676, 3695], 'cross-tolerance': [908], '(13.Miao': [911], 'Yin': [913], 'X.H.': [914], 'Pei': [915], 'D.S.': [916], 'Zhang': [917, 919], 'Q.G.': [918], 'G.Y.': [920], 'Biol.': [922], 'Chem.': [923], '280:': [925, 3944], '21693-21699Abstract': [926], 'Full': [927, 929, 1055, 1057], 'Text': [928, 930, 1056, 1058], 'PDF': [931, 1059], '(78)': [934], 'Scholar)': [936, 1921], '14.Tauskela': [965, 1021], 'Hewitt': [969, 1025, 1233, 4098], 'Monette': [971, 1027, 1235, 1840, 1908, 2009, 2135], 'Paris': [973, 1029, 1237], 'Neuroscience.': [979, 1035, 1243, 1576], '107:': [981, 1037, 1245], '571-584Crossref': [982, 1038, 1246], '(35)': [985, 1041, 1249], 'To': [988, 3344, 3450], 'date,': [989], 'either': [992, 1669, 2449, 4190], 'death"': [1007], '15.Dirnagl': [1044], 'Simon': [1046], 'R.P.': [1047], 'Hallenbeck': [1048], 'J.M.': [1049], 'Trends': [1050], '26:': [1053, 1400], '248-254Abstract': [1054], '(721)': [1062], 'trait': [1066], 'shared': [1067], 'some': [1069, 3622], 'other': [1070, 1784, 3218], 'paradigms': [1072], 'Induction': [1091], 'state': [1094, 1117], 'resistant': [1095], 'brink': [1101, 1210, 1657], 'death': [1103, 1212, 1659, 3733], 'may': [1105, 1207, 1219, 4017], '"byproduct"': [1108], 'responding': [1111], 'intense': [1114], 'stressor,': [1115], 'persists': [1119], 'only': [1120, 3671], 'until': [1121], 'normal': [1122, 1166], 'baseline': [1123, 3047, 3216], 'homeostasis': [1124], 'restored.': [1126], 'Can': [1127], 'engaged': [1131], 'against': [1135, 3639, 3646, 3991], 'without': [1137], 'approaching': [1138], 'threshold': [1140], 'required': [1141, 3522, 3984], 'death?': [1143], 'Synaptic': [1144], 'plasticity': [1145, 1206], 'describes': [1146], 'whereby': [1149], 'strength': [1151], 'synapses,': [1153, 1162], 'efficiency': [1158], 'communication': [1160], 'between': [1161, 2207, 3097, 3118, 3214], 'modified': [1164], '(as': [1167, 3270], 'pathological)': [1170], 'activity.': [1171, 1503, 3506], 'Neuronal': [1172, 1970], 'fate': [1173], 'differ': [1175], 'depending': [1176], 'location': [1179], 'neurons,': [1184], 'survival': [1186], 'demise': [1188], 'linked': [1189], 'activation,': [1196], 'respectively.': [1197], 'Perhaps': [1198], 'associated': [1203, 1222, 1649], 'circumvent': [1208], 'preconditioning,': [1215, 3396, 3455, 3630, 4203], 'constraint': [1217], '(14.Tauskela': [1229], 'Here': [1252], 'we': [1253, 3737, 3800, 4054], 'investigate': [1254], 'increasing': [1256], 'input': [1258], 'neurons.': [1267], 'Elevations': [1268], 'activity,': [1271], 'bicuculline,': [1281, 3480], 'sometimes': [1282], 'combined': [1283], 'K+': [1286], 'channel': [1287, 2996, 3052, 3145, 3193, 3953, 4146], '(4-AP/bic': [1290, 3373], 'treatment),': [1291], 'treatment': [1294, 1620, 2710, 3435, 3813], 'low': [1296, 2195, 3628, 3964, 4006, 4156, 4199], 'concentrations': [1297, 3699, 3924, 3936], 'culture': [1304, 1662, 1869, 1888, 3883], 'apoptosis': [1306], 'serum': [1309, 1693, 1714], 'agents,': [1316], 'excitotoxicity': [1319], 'apoptotic': [1322, 3803, 3828], 'non-apoptotic': [1324], 'manners,': [1325], 'oxidative': [1327], 'stress': [1328, 4092], '(16.Hardingham': [1329, 3529, 3840], 'G.E.': [1330, 1354, 1396, 1474, 3530, 3769, 3841], 'Fukunaga': [1331, 3531, 3842], 'Bading': [1333, 1351, 1393, 1411, 3533, 3756, 3772, 3844, 3860], 'Nat.': [1335, 1475, 3535, 3774, 3846], '5:': [1338, 3538, 3849], '405-414Crossref': [1339, 3539, 3850], '(1368)': [1342, 3542, 3853], '17.Papadia': [1345], 'Stevenson': [1347], 'Hardingham': [1349, 1353, 1391, 1395, 1473], 'N.R.': [1350, 1392], '25:': [1358, 1378], '4279-4287Crossref': [1359], '(241)': [1362], '18.Lee': [1365], 'Butcher': [1367], 'G.Q.': [1368], 'Hoyt': [1369], 'Impey': [1371], 'Obrietan': [1373], '1137-1148Crossref': [1379], '(146)': [1382], '19.Soriano': [1385], 'F.X.': [1386, 1440], 'Papadia': [1387], 'Hofmann': [1389], 'F.': [1390, 1442, 3333], '2006;': [1399, 1560], '4509-4518Crossref': [1401], '(202)': [1404], '20.Bengtson': [1407, 3856], 'C.P.': [1408, 3753, 3857], 'Dick': [1409, 3754, 3858], 'O.': [1410, 3755, 3859], 'BMC.': [1413, 3758, 3862], '2008;': [1415, 1477, 1577, 3760, 3864], '9:': [1416, 3761, 3865], '11Crossref': [1417, 3762, 3866], '(38)': [1420, 3765, 3869], '21.Martel,': [1423], 'A.,': [1425], 'Wyllie,': [1426], 'J.,': [1428], 'Hardingham,': [1430], 'G.': [1431, 1458, 1530, 1835, 1903, 2004, 2130], 'E.': [1432, 1831, 1899, 2000, 2126], '(2008)': [1433], 'Neuroscience,in': [1434], 'pressGoogle': [1435], '22.Papadia': [1437], 'Soriano': [1439], 'Leveille': [1441], 'Martel': [1443], 'Dakin': [1445], 'K.A.': [1446], 'Hansen': [1447], 'H.H.': [1448], 'Kaindl': [1449], 'Sifringer': [1451], 'Fowler': [1453], 'Stefovska': [1455], 'V.': [1456], 'McKenzie': [1457], 'Craigon': [1459], 'Corriveau': [1461], 'Ghazal': [1463], 'Horsburgh': [1465], 'Yankner': [1467], 'B.A.': [1468], 'Wyllie': [1469], 'D.J.': [1470], 'Ikonomidou': [1471], 'C.': [1472, 1546, 4245], '476-487Crossref': [1479], '(424)': [1482], 'Activation': [1485], 'receptor-mediated': [1489, 1629], '(pCREB)': [1495], 'implicated': [1497], 'neuroprotection': [1499, 1591], 'elicited': [1500], 'Likewise,': [1504], 'induces': [1510, 3310, 4231], 'kinases,': [1518], 'ERK1/2,': [1519], 'which': [1520, 1632, 3274, 3293, 3309], 'members': [1522], 'family,': [1528], '(23.Sutton': [1529], 'Chandler': [1531, 1574], 'Neurochem.': [1534, 3334], '82:': [1536], '1097-1105Crossref': [1537], '(105)': [1540], '24.Ivanov': [1543], 'Pellegrino': [1545], 'Rama': [1547], 'Dumalska': [1549], 'I.': [1550, 1557], 'Salyha': [1551], 'Ben': [1553], 'Ari': [1554], 'Medina': [1556], 'Physiol.': [1559], '572:': [1561], '789-798Crossref': [1562], '(261)': [1565], '25.Mulholland': [1568], 'P.J.': [1569], 'Luong': [1570], 'N.T.': [1571], 'Woodward': [1572], 'J.J.': [1573], '151:': [1578], '419-427Crossref': [1579], '(24)': [1582], 'has': [1596], 'yet': [1598], 'been': [1599], 'examined.': [1600], 'In': [1601, 3392, 3795], 'contrast,': [1602, 3411], '"shut-off"': [1614], 'pathway.': [1615], 'signaling': [1630, 1648], 'pathway,': [1631], 'culminated': [1633], 'thereby': [1638], 'accomplishing': [1639], 'aligned': [1645], 'plasticity,': [1652], 'rather': [1653], 'than': [1654, 3705, 4188], 'stress.': [1660], 'Materials—Tissue': [1661], 'dishes': [1663], 'plates': [1665, 1925], 'were': [1666, 1683, 1749, 1786, 1798, 1813, 2025, 2079, 2107, 2257, 2305, 2354, 2387, 2409, 2478, 2518, 2563, 2589, 2642, 2667, 2681, 2749, 2820, 2943, 2948, 2985, 3053, 3090, 3112, 3204, 3231, 3246, 3363, 3460, 3785, 3896, 3925], 'purchased': [1667, 1684, 1750, 1787, 1799], 'Du': [1670], 'Pont-Invitrogen': [1671], '(Burlington,': [1672], 'Ontario,': [1673, 1679, 1803, 2605], 'Canada)': [1674, 2574], 'VWR': [1676], 'Canlab': [1677], '(Mississauga,': [1678, 1802], 'Canada).': [1680, 1712, 1804, 2203, 2606], 'Glass': [1681], 'coverslips': [1682, 2208, 2264], 'Bellco': [1686], 'Glass,': [1687], 'Inc.': [1688], '(Vineland,': [1689], 'NJ).': [1690], 'Fetal': [1691], 'bovine': [1692], 'bought': [1695, 1724, 1732], 'Gemini': [1697], 'Bio': [1698], '(Woodland,': [1699], 'CA).': [1700, 1737, 2763], 'Minimal': [1701], 'essential': [1702], 'medium': [1703], 'Wisent': [1707], 'Canadian': [1708], 'Laboratories': [1709, 1719], '(St-Bruno,': [1710], 'Quebec,': [1711], 'Horse': [1713], 'acquired': [1716, 2108, 2230, 2258, 2582, 2930], 'HyClone': [1718], '(Logan,': [1720], 'UT).': [1721], 'Fluo-4-AM': [1722, 2122], 'Molecular': [1726, 2725], 'Probes': [1727], '(Eugene,': [1728], 'OR).': [1729], 'H89': [1730], 'Axxora': [1734], '(San': [1735], 'Diego,': [1736], '4-AP,': [1738, 3561], '5,7-dichlorothiokynurenic': [1739], '2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide': [1741], '(NBQX),': [1742], 'maleate': [1744], '(MK-801),': [1745], 'KN-62,': [1746], 'KN-93': [1748], 'Tocris': [1752], 'Bioscience': [1753], '(Ellisville,': [1754], 'MO).': [1755], 'Bicuculline,': [1756], '8-cyclopenthyltheophylline,': [1757], 'glybenclamide,': [1758], 'memantine,': [1759], 'nifedipine,': [1760], 'N-methyl-d-aspartate': [1761], '(NMDA),': [1762], 'iodide': [1764], '(PI),': [1765], 'tetrodotoxin': [1766], '(TTX),': [1767], 'U0126,': [1768], 'KT': [1769], '5720,': [1770], 'tolbutamide,': [1771], 'PKA': [1772], 'inhibitory': [1773], 'fragment': [1774], '14–22': [1775], '(myristoylated),': [1776], 'staurosporine,': [1777], 'protease': [1779, 2337], 'mixture': [1780, 2338], 'inhibitor,': [1781], 'all': [1783, 2094, 3102, 3593], 'reagents': [1785], 'Sigma.': [1789], 'The': [1790, 2371, 3024, 3085, 3108, 3465, 3545, 3607, 3690], 'serum-free': [1791, 2670], 'block': [1793, 2663, 2672, 4020], 'Antibody': [1795, 2689, 2696], 'Diluting': [1796, 2690, 2697], 'Buffer': [1797], 'DakoCytomation': [1801], 'Preparation': [1805], 'Cultures—Cultures': [1807], 'E18': [1809], 'rat': [1810, 3359], 'described': [1816, 1895, 1980], 'previously,': [1817], 'experiments': [1819, 2614], 'performed': [1820, 1892, 2442, 2633, 2767, 2944], 'grown': [1823], '14–18': [1824], '(26.Tauskela': [1828, 1896, 1997, 2123], 'Brunette': [1830, 1898, 1999, 2125], "O'Reilly": [1832, 1900, 2001, 2127], 'N.': [1833, 1901, 2002, 2128, 4243], 'Mealing': [1834, 1902, 2003, 2129], 'T.F.': [1839, 1907, 2008, 2134], 'FASEB': [1844, 1912, 2013, 2139], '1734-1736Crossref': [1848, 1916, 2017, 2143], '(30)': [1851, 1919, 2020, 2146], 'Experimental': [1854], 'Treatment': [1855], 'Cultures—For': [1857], 'experiments,': [1859], 'each': [1860, 2055, 2213, 2249, 2253, 2485, 2513, 2623, 2935, 2968, 2995, 3012, 3051, 3181, 3191], '12-well': [1861, 1924], 'plate': [1862], 'subjected': [1864, 2519], '4': [1866, 2369, 2435, 2438, 3672], 'conditions': [1867, 3171, 3548], 'medium:': [1870], '(preconditioned),': [1872], 'control': [1873, 4064], 'wash,': [1874], 'plus': [1876], 'antagonist/inhibitor,': [1877], 'antagonist/inhibitor': [1879], 'alone,': [1880, 2233], 'followed': [1881, 2045, 2708, 3001, 3196, 3378], 'washing': [1883], 'replacement': [1885], 'stored': [1887, 2347], 'medium.': [1889], 'previously': [1894, 1981, 2117], 'placing': [1923], 'containing': [1926, 2031], 'exposed': [1929, 2026, 2084, 2312, 2576, 2650, 2668, 3364, 3387], 'basic': [1932, 2028, 2308], 'salt': [1933, 2029, 2309], 'solution': [1934, 2030, 2310, 2568], '(which': [1935], 'had': [1936, 2852, 2859, 4170], 'composition': [1939], '(n': [1940], 'mm):': [1941], '140': [1942, 2418], 'NaCl,': [1943, 2323, 2420], '5': [1944, 2366, 2483, 3170, 3173], 'KCl,': [1945], '2': [1946, 2110, 2324], 'CaCl2,': [1947], '20': [1948, 2061, 2067, 2178, 2932, 2956, 3583], 'HEPES,': [1949], '0.03': [1950], 'glycine,': [1951], 'pH': [1952, 2424], '7.4)': [1953], '37': [1956], '°C': [1957, 2537, 2906], 'incubator': [1958, 2900], 'housed': [1959], 'anaerobic': [1962], 'glovebox': [1963], '(Forma': [1964], 'Scientific,': [1965], 'Marjetta,': [1966], 'OH).': [1967], 'Assessment': [1968], 'Injury—Neuronal': [1971], 'injury': [1972], 'assessed': [1974], '24': [1975], 'h': [1976, 2428, 2436, 2676, 2704, 2731, 2848, 3600, 3673], 'treatments': [1978, 3592], 'using': [1982, 1987, 2193, 2378, 2597, 2753, 2768, 2939, 2945, 4140], 'fluorescence': [1985, 1991, 2049, 2105, 3428], 'quantitated': [1986], 'Cytofluor': [1989], '2350': [1990], 'platereader': [1992], '(Millipore': [1993], 'Corp.,': [1994], 'Bedford,': [1995], 'MA)': [1996], 'Briefly,': [2023], 'mm': [2033, 2319, 2322, 2325, 2416, 2419, 2525, 2528, 2816], '33': [2036], 'μg/ml': [2037], 'PI': [2038, 2072, 3406, 3427], '30': [2040, 2357, 2533], 'min': [2041, 2091, 2367, 2484, 2534, 3390], '22': [2043], '°C,': [2044], 'measurement': [2047], 'intensities': [2050, 2279], 'four': [2052], 'locations': [2053], 'within': [2054, 2583, 2967], '(Ex': [2057, 2170], '=': [2058, 2064, 3015, 3127, 3162, 3176, 3178], '520': [2059], '±': [2060, 2066, 2172, 2177, 3227], 'nm;': [2062, 2174], 'Em': [2063, 2175], '645': [2065], 'nm).': [2068], 'For': [2069, 2252, 2889, 3180], 'normalization': [2070], 'purposes,': [2071], 'added': [2074, 3830], 'sister': [2076], 'untreated': [2080], '(0%': [2081], 'PI-uptake)': [2082], '100': [2086, 2867], 'μm': [2087, 2121, 3584, 3588], '15': [2090, 2173], 'kill': [2093], '(100%': [2096], 'PI-uptake).': [2097], 'Intracellular': [2098], 'Spiking—To': [2100], 'monitor': [2101], 'intracellular': [2102, 3317, 3457], 'images': [2106, 2191, 2256], 'every': [2109, 3030], 's': [2111, 2114, 2358, 2926], '120': [2113], 'loaded': [2118, 2388], '4.5': [2120], 'Excitation': [2149], 'delivered': [2151], 'through': [2152, 3057], 'Lambda': [2154], 'DG-5': [2155], 'shutter': [2156], 'instrument': [2157], '(Sutter': [2158], 'Instrument': [2159], 'Co,': [2160], 'Novato,': [2161], 'CA)': [2162, 2555], 'housing': [2163], 'Zeiss': [2165, 2771], 'Axiovert': [2166], '200': [2167], 'inverted': [2168, 2772], 'microscope': [2169, 2775], '480': [2171], '535': [2176], 'nm)': [2179], 'equipped': [2180], 'Fluar': [2183], '40×/1.3': [2184], 'numerical': [2185], 'aperture': [2186], 'oil': [2187], 'immersion': [2188], 'objective,': [2189], 'captured': [2192], 'light-sensitive': [2196], 'Retiga': [2197], 'Exi': [2198], 'camera': [2199], '(QImaging,': [2200], 'Burnaby,': [2201], 'BC,': [2202], 'Due': [2204], 'variability': [2206], '4-AP/bic-induced': [2210], 'Ca2+-spiking': [2211], 'profiles,': [2212], 'coverslip': [2214], 'served': [2215, 2743], 'internal': [2219], 'control.': [2220, 2747], 'minimum': [2222, 2261, 2267, 2617, 3686], 'two': [2224, 2263, 2269, 2627, 3700], 'sets': [2225], '120-s': [2227], 'runs': [2228], 'then': [2235, 2433, 2682], 'drug,': [2240], 'different': [2243, 2270, 2620, 3874, 3881], 'region': [2244], 'interest': [2246], 'chosen': [2247], 'spike': [2250, 2275], 'train.': [2251], 'drug': [2254], 'evaluated,': [2255, 3926], 'platings.': [2271], 'Plots': [2272], 'trains': [2276], 'represent': [2277], 'average': [2278, 2883, 3184], 'calculated': [2280, 3044], '12–15': [2282], 'soma.': [2284], 'Immunoblotting—The': [2285], 'effect': [2286, 4118, 4172], 'levels': [2290, 3459, 3476], '(phosphorylated': [2293], 'non-phosphorylated),': [2295], '(phosphorylated),': [2297], 'actin': [2299], 'determined': [2301, 2377, 3555], 'immunoblotting.': [2303], 'Cultures': [2304, 2641, 2680], 'washed': [2306, 2479, 2797], 'radioimmune': [2314], 'precipitation': [2315], 'assay': [2316, 2383], 'buffer': [2317, 2523], 'Tris,': [2320, 2417, 2526], '150': [2321], 'EDTA,': [2326], '0.1%': [2327, 2812], 'SDS,': [2328, 2529], '1%': [2329, 2331, 2421], 'deoxycholate,': [2330], 'Triton': [2332, 2653], 'X-100,': [2333], 'phenylmethylsulfonyl': [2334], 'fluoride,': [2335], 'inhibitor),': [2339], 'manually': [2340], 'homogenized': [2341], 'over': [2342, 2997], 'ice,': [2343], 'vortexed': [2344, 2355], 'briefly': [2345], '–80': [2349], '°C.': [2350, 2370, 2439], 'Upon': [2351], 're-thawing,': [2352], 'samples': [2353, 2966], 'centrifuged': [2360], '5000': [2362], '×': [2363, 2481, 3017, 3172], 'g': [2364], 'concentration': [2373, 3559, 3708], 'supernatants': [2375], 'Bio-Rad': [2380], 'DC': [2381], 'kit.': [2384], 'Protein': [2385], 'homogenates': [2386], '(15': [2389], 'μg)': [2390], 'onto': [2391], '10%': [2392], 'SDS-PAGE': [2393], 'gels': [2394], 'subsequently': [2396], 'transferred': [2397], 'polyvinylidene': [2399], 'difluoride': [2400], 'membranes': [2401, 2517], '(NEN': [2402], 'Life': [2403], 'Products,': [2405], 'Boston,': [2406], 'MA).': [2407, 2476], 'Membranes': [2408, 2477, 2562], 'blocked': [2410], '5%': [2412, 2454, 2467, 2506], 'skim': [2413], 'milk-TBST': [2414], '(200': [2415], 'Tween-20': [2422], '(v/v),': [2423], '7.60)': [2425], '1': [2427, 2675, 2703, 2730, 2959], 'room': [2430, 2678, 2706, 2733], 'temperature,': [2431, 2707], 'Immunoblotting': [2440], 'overnight': [2444, 2810], 'incubation': [2445], '(4': [2446], '°C)': [2447], 'anti-phospho-Ser133': [2450, 2685], '(1:2000': [2452], 'milk-TBST,': [2455, 2468, 2507], 'rabbit': [2456, 2547, 2559], 'polyclonal,': [2457, 2548, 2560], 'Upstate': [2458], '(Millipore),': [2459], 'Lake': [2460], 'Placid,': [2461], 'NY)': [2462], 'anti-phospho-ERK1/2': [2464], '(1:1000': [2465], 'mouse': [2469, 2699], 'monoclonal': [2470], '(E10),': [2471], 'Cell': [2472], 'Signaling': [2473], 'Technology,': [2474], 'Beverly,': [2475], 'placed': [2487, 2826, 2902], 'into': [2488, 2822, 2903], 'appropriate': [2490], 'horseradish': [2491], 'peroxidase-linked': [2492], 'anti-mouse/rabbit': [2493], 'secondary': [2494, 2712], 'antibody': [2495, 2741], '(1:5000': [2496], 'anti-pCREB': [2498], '1:2000': [2502], 'anti-pERK1/2': [2504], 'goat': [2508, 2717, 2723], 'anti-rabbit,': [2509], 'Amersham': [2510], 'Biosciences).': [2511], 'After': [2512], 'phosphor-antibody': [2514], 'examined,': [2516], 'stripping': [2522], '(62': [2524], '69': [2527], '0.8%': [2530], 'β-mercaptoethanol)': [2531], '55': [2536], 'constant': [2539], 'agitation': [2540], 'before': [2541], 'being': [2542], 'reprobed': [2543], 'anti-CREB': [2545], '(1:1000,': [2546], 'Santa': [2549, 2553], 'Cruz': [2550], 'Biotechnology': [2551], 'Cruz,': [2554], 'anti-actin': [2557], '(1:5000,': [2558], 'Sigma-Aldrich).': [2561], 'treated': [2564, 2683], 'ECL': [2567], '(Amersham': [2569], 'Biosciences,': [2570], 'Baie': [2571], "d'Urfè,": [2572], 'PQ,': [2573], 'imaging': [2578, 2765], 'film': [2579], '(Kodak).': [2580], 'Images': [2581], 'linear': [2585], 'range': [2586, 3546], 'exposures': [2588], 'quantified': [2590], 'densitometric': [2592], 'analyses': [2593], 'background-subtracted': [2595], 'bands': [2596], 'Northern': [2598], 'Eclipse': [2599], 'software': [2600], '(Empix': [2601], 'Imaging': [2602], 'Mississauga,': [2604], 'Immunoblots': [2607], 'representative': [2609], 'three': [2611, 2619, 2629], 'five': [2613], 'platings,': [2621], 'experiment': [2624], 'comprised': [2625], 'wells/condition.': [2630], 'Immunofluorescence—Immunofluorescence': [2631], 'detect': [2637], 'cellular': [2638], 'pCREB': [2639], 'immunoreactivity.': [2640], 'fixed': [2643], '4%': [2645], 'paraformaldehyde': [2646], '10': [2648, 2659], 'min,': [2649, 2660, 2913], '0.25%': [2652], 'X-100': [2654], 'phosphate-buffered': [2656], 'saline': [2657], 'and,': [2661], 'nonspecific': [2664], 'staining,': [2665], '(DakoCytomation)': [2673], 'temperature.': [2679], '(1:300': [2687, 2694], 'Buffer)': [2691], 'anti-MAP2': [2693], 'Buffer,': [2698], 'monoclonal,': [2700], 'Sigma)': [2701], 'antibodies': [2713], '(Alexa': [2714], 'Fluor': [2715, 2721], '488': [2716], 'anti-rabbit': [2718], 'Alexa': [2720], '568': [2722], 'anti-mouse,': [2724], 'Probes,': [2726], 'Eugene,': [2727], 'OR)': [2728], 'temperature': [2734], 'protected': [2735], 'light.': [2737], 'Omitting': [2738], 'primary': [2740], 'negative': [2746], 'Coverslips': [2748], 'mounted': [2750], 'slides': [2752], 'Vectashield': [2754], 'Hard': [2755], 'Set': [2756], 'Mounting': [2757], 'Medium': [2758], 'Fluorescence': [2760, 2764], '(Vector,': [2761], 'Burlingame,': [2762], 'LSM-410': [2770], 'laser': [2773], 'scanning': [2774, 3056], '(Carl': [2776], 'Zeiss,': [2777], 'Thornwood,': [2778], 'NY).': [2779], 'MEA': [2780, 2829, 2894, 2940, 3151], 'Acquisition': [2781], 'Analysis—Prior': [2783], 'initial': [2785], 'use,': [2786], 'dish': [2789], '(MEA,': [2790], 'Alpha': [2791], 'MED': [2792, 2922], 'Sciences,': [2793], 'Tokyo,': [2794], 'Japan)': [2795], 'deionized': [2799], 'water,': [2800], 'sterilized': [2801], '70%': [2803], 'ethanol': [2804], 'UV': [2806], 'radiation,': [2807], 'coated': [2809], 'polyethyleneimine': [2813], '25': [2815], 'borate': [2817], 'buffer.': [2818], 'Cells': [2819], 'dispensed': [2821], 'silicon': [2824], 'tube': [2825], 'allow': [2831], 'coverage': [2832], '64': [2835, 2937], 'electrodes': [2836], 'perimeter': [2840], 'reference': [2841], 'electrodes;': [2842], 'tubing': [2844], 'removed': [2846, 2896], 'later': [2849], 'after': [2850, 3652, 3831], 'cells': [2851], 'adhered': [2853], 'MEA.': [2856], 'Each': [2857, 3150], 'electrode': [2858], '20-μm': [2861], 'diameter,': [2862], 'inter-electrode': [2864], 'distance': [2865], 'μm,': [2868, 3914, 3920], 'impedance': [2870], '<22': [2872], 'kΩ': [2873], '(1': [2874], 'kHz,': [2875], '50': [2876], 'mV': [2877], 'sinusoidal': [2879], 'wave),': [2880], 'RMS': [2884], 'noise': [2885], '4.07': [2887], 'μV.': [2888], 'recording': [2891, 2919], 'session,': [2892], 'standard': [2899, 2992, 3005], '34': [2905], 'incubator,': [2907], 'allowed': [2908], 'recover': [2910], '15–30': [2912], 'connected': [2915], 'MED64': [2918], 'system': [2920], '(Alpha': [2921], 'Sciences),': [2923], '60': [2925], 'kHz': [2933, 2957, 2960], 'software.': [2941], 'Analyses': [2942], 'Matlab.': [2946], 'Data': [2947], 'pre-processed': [2949], 'down-sampling': [2951], 'original': [2953], 'resolution': [2954], 'taking': [2962, 2975], 'mean': [2964, 2990, 3010, 3226], 'across': [2965, 3101], 'bin': [2969], 'time': [2970, 3060], '(other': [2971], 'techniques': [2972], 'such': [2973, 3325], 'maximum': [2977], 'value': [2978, 3075, 3082], 'provided': [2979, 3594], 'similar': [2980], 'qualitative': [2981], 'results).': [2982], 'Confidence': [2983], 'lines': [2984], 'computed': [2986], 'determining': [2988, 3063, 3201], 'deviation': [2993, 3006], '60-s': [2999, 3059], 'window,': [3000], 'subtracting': [3003], '(S.D.)': [3007], 'channel:': [3013], 'Confidence-Linec': [3014], 'Meanc–(3': [3016], 'S.D.c),': [3018], 'where': [3019, 3129], 'c': [3020, 3146], 'indexes': [3021, 3131], 'channels.': [3023], 'same': [3025], 'procedure': [3026], 'experimental': [3031], 'condition,': [3032], 'except': [3033], 'S.D.': [3035], 'compute': [3038], 'confidence': [3040, 3069, 3078, 3124], 'line': [3041, 3070, 3079], 'always': [3043], 'condition.': [3048, 3107], 'Peaks': [3049], 'identified': [3054, 3897], 'window': [3061], 'amplitude': [3066, 3111, 3121, 3142, 3187, 3211, 3468], 'crossed': [3067], '(i.e.': [3071], 'went': [3072], 'above': [3076, 3474], 'below': [3083], 'it).': [3084], 'temporal': [3086, 3095], 'distributions': [3087, 3109], 'peaks': [3089, 3189, 3213], 'computing': [3093, 3115], 'interval': [3096, 3619, 3634], 'peaks,': [3098], 'averaging': [3100], 'given': [3106], 'difference': [3117], 'peak': [3120, 3148], 'line:': [3125], 'PeakAmplitudec,t': [3126], 'Amplitudec,t–ConfidenceLinec,': [3128], 't': [3130, 3159, 3241], 'timing': [3133, 3185, 3209], 'peak,': [3136], 'Amplitudec,t': [3138], 'raw': [3141], 't.': [3149], 'analyzed': [3153], 'separately': [3154], 'performing': [3156], "Student's": [3158, 3240], 'test': [3160, 3250], '(α': [3161], '0.05,': [3163, 3263], 'Bonferroni': [3165, 3249, 3266], 'correction': [3166, 3267], 'multiple': [3168, 3254], 'comparisons:': [3169], 'cultures,': [3174, 3420], 'α': [3175], '0.05/25': [3177], '0.002).': [3179], 'individual': [3192], 'determined,': [3195], 'comparisons': [3198, 3230], 'aimed': [3199], 'there': [3203], 'significant': [3205, 3244], 'differences': [3206, 3245], 'conditions.': [3219], 'Statistical': [3220, 3229, 3256], 'Analyses—Data': [3221], 'presented': [3223], 'S.E.': [3228], 'made': [3232], 'variance': [3236], '(ANOVA)': [3237], 'test.': [3242], 'When': [3243], 'observed,': [3247], 'employed': [3252], 'comparisons.': [3255], 'significance': [3257], 'inferred': [3259], 'p': [3261, 3276], '<': [3262, 3277], 'unless': [3264], 'noted': [3271], 'above),': [3272], 'case': [3275], '0.002.': [3278], 'Induces': [3281], 'Tolerance—Neuronal': [3283], 'glutamatergic': [3284], 'enhanced': [3289], '(4-AP),': [3292], 'prolongs': [3294], 'duration': [3296, 3687], 'potentials,': [3300], '(bic),': [3304], 'network': [3311], 'disinhibition,': [3312], 'potential-dependent': [3316, 3980], 'release': [3322, 3982], 'neurotransmitters': [3324], '(27.Tapia': [3328], 'Medina-Ceja': [3330], 'L.': [3331], 'Pena': [3332], 'Int.': [3335], '34:': [3337], '23-31Crossref': [3338], '(66)': [3341], 'determine': [3345], 'excitatory': [3347], 'elevated': [3349], 'neuron': [3361, 3882], '(2.5': [3367], 'mm)': [3368], 'preconditioning)': [3374], '48': [3376], 'h,': [3377], 'washout': [3380, 3574, 3613, 3833], '24-h': [3383], 'recovery': [3384, 3570, 3609], 'period,': [3385], '65–80': [3389], 'absence': [3394], 'destruction': [3400], 'morphology': [3403, 3423], 'substantial': [3405], 'uptake': [3407], 'fluorescence;': [3409], 'did': [3413, 3674, 3717, 4124], 'have': [3415, 3498], 'these': [3416, 4168], 'effects': [3417], 'because': [3421, 3927], 'preserved': [3425], 'negligible': [3430], '(Fig.': [3431, 3490, 3518, 3575, 3679, 4007, 4012, 4163, 4177, 4196, 4200], '1,': [3432, 3576], 'A–H).': [3433], 'Bicuculline': [3434], 'alone': [3436, 3496, 4070, 4192], 'effective': [3440], 'providing': [3444], '(data': [3447, 3663], 'shown).': [3449, 3665], 'confirm': [3451, 3740], 'monitored': [3461], 'Fluo-4-loaded': [3463], 'cultures.': [3464], 'frequency': [3466], 'action-potential-dependent': [3470], 'spikes': [3472], 'increased': [3473, 3484], 'background': [3475], 'upon': [3477], 'further': [3483], 'co-addition': [3487], '1I).': [3491], 'Hence,': [3492], 'might': [3497, 3877], 'failed': [3499], 'due': [3500, 4080], 'insufficient': [3502], 'elevation': [3503], 'Blocking': [3507, 4142], 'Na+': [3508, 3952], 'TTX': [3511, 3967], '1I),': [3519], 'confirming': [3520], 'electrically': [3525], 'driven': [3526], 'able': [3549], 'provide': [3551], 'varying': [3557], 'durations': [3564], 'period': [3571, 3610], 'J–P).': [3577], 'Concentrations': [3578], 'ranging': [3581], '("low")': [3585], '2500': [3587], '("high")': [3589], 'robust': [3595], '24–48': [3599], 'representing': [3601], 'optimum': [3603, 3608], 'length': [3604], 'treatment.': [3606, 4015], '0–48': [3615], 'h;': [3616], '72-h': [3618], 'loss': [3623], 'whereas': [3631], '96-h': [3633], 'no': [3637], 'protection': [3638, 3647], 'any': [3642, 3649, 4171], 'Arguing': [3645], 'remaining': [3651], 'neuroprotective': [3662], 'Exposing': [3666], '1P),': [3680], 'suggesting': [3681, 4204], 'exposure.': [3689], 'ability': [3691], 'orders': [3701], 'magnitude': [3703], 'lower': [3704], '(∼5': [3709], 'mm;': [3710], 'shown)': [3713], 'suggests': [3714], 'threaten': [3719], 'survival.': [3721], 'Because': [3722], 'excessive': [3723], '(excitotoxicity)': [3730], 'underlies': [3731], 'attempted': [3738], '(20.Bengtson': [3752], '28.Hardingham': [3768], 'Arnold': [3770], 'F.J.': [3771], '4:': [3777], '261-267Crossref': [3778], '(439)': [3781], 'successful': [3787], '(supplemental': [3788, 3818, 3837, 4076], 'Fig.': [3789, 3819, 3838, 3915, 3921, 4077], 'S1,': [3790], 'B,': [3793], 'respectively).': [3794], 'view': [3796], 'discrepancy,': [3799], 'evaluated': [3801], 'confirmed.': [3807], 'staurosporine': [3810], '(acute)': [3814], 'observed': [3817], 'S2,': [3820], 'B),': [3823], 'agent': [3829], '(delayed)': [3834], 'verified': [3836], 'S2C)': [3839], 'Overall,': [3872], 'neurotoxicity': [3875], 'profiles': [3876], 'attributed': [3879], 'systems': [3884], '(hippocampals': [3885], 'elsewhere': [3886], 'versus': [3887], 'corticals).': [3888], 'Receptor': [3889], 'Dependence': [3890], 'Preconditioning—Receptors': [3892], 'activated': [3893, 3932], 'evaluating': [3899], 'whether': [3900], 'including': [3901], 'antagonist': [3904, 4086, 4191], 'suppressed': [3907, 3995, 4160, 4185], 'tolerance;': [3909], 'both': [3910, 3961, 4194], 'highest': [3912], '(2500': [3913], '2A)': [3916, 4013, 4197], '(20': [3919], '2B)': [3922, 4008, 4201], 'additional': [3928], 'millimolar': [3934], '(29.Rogawski': [3937], 'Barker': [3939], 'J.L.': [3940], '1983;': [3943], '180-185Crossref': [3945], '(87)': [3948], 'reversed': [3956], 'produced': [3959], '(although': [3966], 'moderately': [3969], 'protective': [3970, 4117], 'unknown': [3976], 'reason).': [3977], 'Thus,': [3978], 'neurotransmitter': [3981], 'development': [3986], 'Protection': [3990], 'significantly': [3994], 'presence': [3998, 4083], 'memantine': [4000, 4180], '(12.5': [4001], 'Memantine': [4016], 'fully': [4019], 'rapid': [4021], '(30.Chen': [4031], 'H.S.': [4032], 'Pellegrini': [4033], 'Aggarwal': [4035], 'S.K.': [4036], 'Lei': [4037], 'S.Z.': [4038], 'Warach': [4039], 'Jensen': [4041], 'F.E.': [4042], 'Lipton': [4043], 'S.A.': [4044], '12:': [4048], '4427-4436Crossref': [4049], 'so': [4053], 'examined': [4055], 'higher': [4057], 'affinity': [4058], 'MK-801.': [4060], 'However,': [4061], 'experiment,': [4065], 'MK-801': [4069, 4123], 'subsequent': [4074], 'S3),': [4078], 'possibly': [4079], 'residual': [4085], 'and/or': [4087], 'induction': [4088], 'response': [4093], '(31.Tremblay': [4094], 'Tauskela': [4100], 'Atkinson': [4104], 'Durkin': [4106], 'J.P.': [4107], '20:': [4111], '7183-7192Crossref': [4112], 'This': [4116], 'likely': [4119], 'accounted': [4120], 'why': [4122], 'reverse': [4126], 'Summarizing,': [4132], 'memantine.': [4141], 'nifedipine': [4149, 4182], 'AMPA': [4151], 'NBQX': [4154], 'partially': [4159], '2B),': [4164], 'neither': [4166], 'antagonists': [4169], '2A).': [4178], 'Combining': [4179], 'L-VGCCs': [4211], 'contributes': [4212], 'generation': [4215], 'accomplished': [4220], 'inducing': [4222], 'epileptiform': [4223], 'kainic': [4226], 'administration': [4228], 'adenosine': [4234], 'A1': [4235], 'KATP': [4238], '(32.Plamondon': [4240], 'Blondeau': [4242], 'Heurteaux': [4244], 'Lazdunski': [4246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2163324763', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-10T02:01:41.177907', 'created_date': '2016-06-24'}
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