Publication Information

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3594, 3610, 3718, 3793, 3802, 3839, 3866, 3893, 3900, 3911, 3920, 3984, 4058, 4070, 4074, 4086, 4213, 4276, 4291, 4296, 4303, 4315, 4319, 4325, 4393, 4400, 4435, 4445, 4453, 4474, 4482, 4507, 4536, 4549, 4558, 4573, 4603, 4612, 4630, 4665, 4683, 4712, 4727, 4735, 4752, 4764, 4767, 4771, 4803, 4807, 4815, 4855, 4901, 4907, 4916, 4924, 4960, 4964, 5003, 5084, 5139, 5147, 5151, 5173, 5199, 5241, 5274, 5301, 5349, 5365], 'nematode': [5, 244, 1526, 1842, 4075], 'Caenorhabditis': [6, 245, 1355], 'elegans': [7, 246, 1356, 1528], 'is': [8, 65, 147, 153, 231, 247, 304, 386, 392, 470, 500, 740, 748, 1036, 1299, 1320, 1326, 1366, 1454, 1458, 1504, 1510, 1760, 2368, 2531, 2565, 2597, 2615, 2885, 3047, 3240, 3387, 3505, 3602, 3717, 3792, 3875, 3881, 4054, 4262, 4331, 4334, 4397, 4419, 4489, 4505, 4518, 4534, 4598, 4673, 4705, 4751, 4774, 4814, 4915, 5000, 5154, 5161, 5195, 5314], 'defective': [9, 248], 'in': [10, 17, 33, 52, 92, 117, 160, 221, 226, 234, 249, 256, 272, 291, 331, 356, 399, 460, 465, 473, 507, 759, 785, 1047, 1107, 1203, 1212, 1270, 1285, 1308, 1317, 1401, 1534, 1536, 1809, 1871, 1916, 1943, 1956, 1977, 2071, 2142, 2153, 2171, 2251, 2352, 2401, 2411, 2435, 2459, 2492, 2558, 2588, 2600, 2625, 2715, 2743, 2795, 2849, 2866, 2936, 2954, 2957, 3082, 3095, 3100, 3172, 3200, 3227, 3254, 3259, 3280, 3291, 3331, 3337, 3349, 3398, 3415, 3426, 3439, 3446, 3454, 3469, 3476, 3479, 3491, 3507, 3514, 3563, 3566, 3582, 3620, 3779, 3806, 3823, 3842, 3883, 3892, 3904, 3979, 4080, 4085, 4212, 4265, 4283, 4299, 4324, 4439, 4465, 4539, 4553, 4577, 4624, 4646, 4670, 4674, 4699, 4716, 4740, 4758, 4791, 4806, 4848, 4883, 4886, 4955, 4973, 4990, 5002, 5083, 5120, 5150, 5166, 5178, 5184, 5231, 5243, 5250, 5269, 5344], 'cytochrome': [12, 251, 614, 1210, 1343, 4221, 5110], 'b': [13, 252, 1211], 'large': [14, 253, 1207, 1338, 4218, 4666], 'subunit': [15, 254, 1110, 4219, 5245], '(Cyt-1/ceSDHC)': [16, 255], 'complex': [18, 177, 257, 416, 545, 550, 579, 616, 773, 782, 1029, 1112, 1279, 1508, 1538, 1822, 1962, 1970, 2066, 2082, 2347, 2350, 2440, 2443, 2481, 2580, 2606, 2628, 2851, 2890, 3391, 3518, 3803, 4225, 4300, 4344, 4470, 4492, 4508, 4527, 4582, 4592, 4621, 4631, 4662, 4680, 4724, 4749, 4779, 4952, 4967, 4978, 5224], 'II': [19, 178, 258, 417, 551, 783, 1030, 1113, 1280, 1298, 1509, 1539, 1971, 2067, 2338, 2351, 2388, 2441, 2581, 2607, 2891, 3392, 3519, 3804, 4226, 4301, 4509, 4528, 4583, 4750, 4953, 4979, 5102, 5225], 'mitochondrial': [22, 208, 261, 447, 762, 1040, 1537, 2073, 2685, 2745, 3052, 3141, 3251, 4060, 4998, 5087, 5167, 5223, 5261, 5304, 5312, 5328, 5353], 'electron': [23, 162, 262, 401, 540, 611, 1271, 1363, 2437, 4461, 4513, 5088], 'transport': [24, 163, 263, 402, 541, 612, 1364, 4462, 5089], 'chain.': [25, 264], 'We': [26, 265, 1350, 1517, 1629, 1774, 2341, 2877, 2963, 4255, 4850, 5357], 'have': [27, 266, 1193, 1518, 1630, 3284, 4281, 4851, 4995, 5079, 5208], 'previously': [28, 267, 1519, 4853], 'shown': [29, 268, 1117, 4852, 5209], 'that': [30, 95, 150, 168, 213, 230, 269, 334, 389, 407, 452, 469, 1035, 1399, 1456, 1507, 1529, 1633, 1777, 1786, 2152, 2364, 2410, 2422, 2605, 2618, 2749, 2846, 3184, 3223, 3242, 3327, 3345, 3389, 3453, 3494, 3588, 3604, 3817, 3853, 3878, 3896, 4223, 4258, 4294, 4337, 4407, 4456, 4486, 4506, 4516, 4535, 4572, 4614, 4653, 4711, 4748, 4796, 4854, 4862, 4878, 4906, 4914, 4944, 4962, 4977, 4997, 5153, 5175, 5210, 5296], 'a': [31, 114, 192, 204, 270, 353, 431, 443, 595, 628, 732, 743, 749, 753, 1039, 1321, 1511, 1521, 1531, 1781, 1889, 1944, 2065, 2081, 2103, 2272, 2381, 2433, 2559, 2579, 2757, 2889, 2896, 2981, 3146, 3211, 3340, 3501, 3564, 3780, 3970, 4209, 4217, 4403, 4409, 4478, 4519, 4554, 4777, 4859, 4983, 5164, 5176, 5189], 'mutation': [32, 171, 271, 410, 1106, 1533, 2430, 2469, 2683, 2848, 3397, 4072, 4211, 4455, 4484, 4537, 4550, 4575, 4714, 4773, 4861, 4880, 4909, 4918, 5242], 'mev-1': [34, 93, 136, 188, 273, 332, 375, 427, 1635, 1715, 1758, 1778, 1983, 2177, 2355, 2366, 2402, 2429, 2468, 2495, 2522, 2549, 2589, 2682, 2692, 2721, 2782, 2822, 2927, 2937, 2958, 3190, 3201, 3228, 3270, 3281, 3292, 3399, 3430, 3440, 3447, 3470, 3480, 3583, 3611, 3623, 3654, 3676, 3692, 3730, 3747, 3764, 3807, 3827, 3854, 3884, 4266, 4284, 4440, 4454, 4483, 4574, 4625, 4650, 4700, 4713, 4741, 4759, 4772, 4856, 4908, 5203, 5211, 5251, 5277, 5345], 'causes': [35, 274, 2583, 2854], 'shortened': [36, 275, 5279], 'life': [37, 276, 5280], 'span': [38, 277, 5281], 'and': [39, 49, 112, 158, 185, 278, 288, 351, 397, 424, 573, 590, 621, 643, 664, 672, 747, 776, 1045, 1125, 1188, 1206, 1313, 1324, 1339, 1348, 1385, 1403, 1467, 1644, 1793, 1866, 1882, 1914, 1954, 1969, 1982, 2059, 2075, 2092, 2110, 2167, 2176, 2227, 2259, 2268, 2296, 2306, 2316, 2349, 2354, 2442, 2447, 2454, 2461, 2488, 2494, 2693, 2699, 2718, 2789, 2798, 2818, 2857, 2893, 2906, 2926, 3085, 3091, 3106, 3262, 3303, 3318, 3334, 3409, 3429, 3460, 3464, 3520, 3528, 3622, 3809, 3826, 3988, 4062, 4094, 4272, 4309, 4327, 4463, 5115, 5144, 5181, 5234, 5255, 5282, 5286, 5293, 5306, 5323, 5327, 5341, 5355], 'rapid': [40, 279], 'accumulation': [41, 280, 3574, 5289], 'aging': [43, 282, 1402, 1640, 2859, 3183, 3987, 5004, 5160], 'markers': [44, 283, 1638], 'such': [45, 284, 1377, 4485, 4515], 'as': [46, 60, 285, 299, 736, 789, 1358, 1378, 1764, 1766, 1989, 2064, 2080, 2123, 2191, 2232, 2477, 2519, 2546, 2723, 2883, 2976, 2980, 3145, 3436, 3659, 3681, 3697, 3735, 3752, 3769, 3910, 4682], 'fluorescent': [47, 286, 1642, 5291], 'materials': [48, 287, 1643, 5292], 'protein': [50, 289, 1329, 1645, 2455, 5294], 'carbonyls': [51, 290], 'an': [53, 105, 216, 292, 344, 455, 1182, 1282, 1327, 2252, 2321, 2332, 2977, 2992, 3092, 3248, 3311, 4449, 4588, 4911, 5182, 5228], 'oxygen-dependent': [54, 293, 5276], 'fashion.': [55, 294], 'However,': [56, 295, 1754, 3339, 3873], 'it': [57, 146, 296, 385, 2614, 2807, 2884, 2991, 3239, 3814, 3874, 4053, 4873, 4903], 'remains': [58, 297], 'unclear': [59, 298], 'to': [61, 97, 236, 300, 336, 475, 501, 528, 561, 571, 575, 606, 623, 761, 766, 1051, 1118, 1197, 1267, 1295, 1353, 1461, 1574, 1762, 1788, 1805, 2031, 2358, 2479, 2585, 2603, 2610, 2710, 2740, 2753, 2945, 3148, 3164, 3176, 3233, 3247, 3273, 3352, 3358, 3571, 3609, 3615, 3898, 3927, 3982, 4056, 4091, 4208, 4302, 4414, 4416, 4425, 4529, 4565, 4611, 4733, 4763, 4794, 4811, 4844, 4876, 4942, 5172, 5284, 5317, 5319, 5325], 'whether': [62, 301], 'this': [63, 302, 522, 2850, 3585, 4081, 4497, 4879], 'hypersensitivity': [64, 303, 1573, 2584, 4308], 'caused': [66, 305], 'by': [67, 75, 306, 314, 731, 742, 1464, 1570, 1864, 1895, 1932, 2135, 2183, 2239, 2280, 2524, 2551, 2577, 2786, 2860, 2870, 2887, 3089, 3394, 4635, 4738, 5156, 5163, 5198, 5240, 5311], 'direct': [68, 307, 2872, 3350, 4479], 'toxicity': [69, 308, 2873], 'exogenous': [72, 311, 2586, 2787, 2875, 5275], 'oxygen': [73, 81, 312, 320, 485, 529, 1374, 1457, 1710, 2587, 2730, 2841, 3628, 3831, 3838, 3926], 'or': [74, 313, 480, 549, 565, 1311, 1835, 1852, 2027, 2220, 2979, 3151, 3630], 'damage': [77, 316, 1398, 2856, 5283, 5324], 'endogenous': [79, 318, 1370, 2862], 'reactive': [80, 319, 484, 1373, 3216], 'species': [82, 321, 486, 1375], 'derived': [83, 322, 3710, 3785, 4648], 'from': [84, 110, 135, 323, 349, 374, 772, 1980, 2055, 2151, 2174, 2432, 2691, 2720, 2770, 2780, 2833, 3286, 3711, 3786, 4412, 4526, 4649, 5222], 'mitochondria.': [85, 324, 3263, 4957], 'Here': [86, 325], 'we': [87, 326, 2688, 2760, 3220, 4280, 5207], 'report': [88, 327], 'important': [89, 217, 328, 456, 2993, 4055], 'biochemical': [90, 329, 1784, 2425, 3267, 3812, 4292, 5216, 5254], 'changes': [91, 330, 1049, 3290, 5236, 5249], 'animals': [94, 333, 1779, 1827, 1858, 1986, 2180, 2214, 2463, 2496, 2695, 2722, 3271, 3481, 3808, 3855, 4285, 4441, 5212], 'serve': [96, 335, 1787], 'explain': [98, 337, 1789, 3983], 'their': [99, 338, 531, 1790], 'abnormalities': [100, 339, 3268], 'under': [101, 121, 141, 340, 360, 380, 1849, 2217, 2497, 2697, 2728, 2802, 2815, 2823, 2961, 3625, 3656, 3664, 3678, 3686, 3694, 3702, 3732, 3740, 3749, 3757, 3766, 3774, 3829, 3836, 4269, 4689], 'normoxic': [102, 341], 'conditions:': [103, 342], '(i)': [104, 343], 'overproduction': [106, 345, 3249, 5221, 5266], 'superoxide': [108, 132, 151, 173, 227, 347, 371, 390, 412, 466, 1379, 1462, 1514, 1816, 2052, 2118, 2130, 2705, 2746, 2751, 2767, 2777, 2830, 2880, 2910, 2949, 3083, 3301, 3320, 3353, 3928, 4065, 4259, 4329, 4339, 4429, 4437, 4467, 4487, 4541, 4578, 4615, 4643, 4687, 4695, 4720, 4756, 4783, 4890, 4935, 4946, 4970, 4987, 5219, 5264], 'anion': [109, 133, 152, 174, 228, 348, 372, 391, 413, 467, 1380, 1463, 1515, 1817, 2008, 2053, 2119, 2131, 2706, 2752, 2768, 2778, 2831, 2881, 2911, 2950, 3084, 3302, 3321, 3354, 3929, 4066, 4260, 4330, 4468, 4488, 4542, 4579, 4616, 4644, 4696, 4721, 4757, 4891, 4936, 4947, 4971, 4988, 5220, 5265], 'mitochondria;': [111, 350], '(ii)': [113, 352], 'reciprocal': [115, 354], 'reduction': [116, 355, 3841, 3923, 4564], 'glutathione': [118, 357, 2169, 2988, 5232], 'content': [119, 358, 3097, 3226], 'even': [120, 359, 4954, 4981], 'atmospheric': [122, 237, 361, 476, 1850, 2218, 2498, 2698, 2729, 3627, 3830], 'oxygen.': [123, 238, 362, 477, 624, 2876, 4531, 4899], 'In': [124, 363, 764, 1265, 1712, 1797, 2939, 3264, 4761, 4958, 5205], 'addition,': [125, 364, 1713, 1798, 2940], 'unlike': [126, 365], 'wild': [127, 198, 366, 437, 1650, 1725, 1830, 2412, 2517, 2544, 2726, 2796, 2813, 3206, 3295, 3427, 3455, 3662, 3684, 3700, 3738, 3755, 3772, 3824, 4671, 4703, 4744, 4991], 'type,': [128, 199, 367, 438], 'levels': [130, 369, 2160, 2456, 2703, 2932, 2968, 3196, 3235, 3258, 3279, 3347, 3466, 3485, 3524, 3581, 3819, 3869, 4279, 4718], 'production': [134, 175, 229, 373, 414, 468, 2120, 2132, 2707, 2769, 2779, 2832, 2882, 2951, 3917, 4261, 4438, 4580, 4645, 4654, 4697, 4722, 4781, 4948, 4972, 4989, 5186], 'mitochondria': [137, 376, 1935, 1978, 2026, 2056, 2091, 2404, 2626, 2690, 2717, 2772, 2783, 2836, 2867, 2947, 3090, 3336, 4326, 4647, 4975], 'were': [138, 377, 1839, 1859, 1867, 1893, 1930, 1951, 1987, 2029, 2121, 2181, 2215, 2230, 2237, 2249, 2278, 2291, 2308, 2318, 2708, 2734, 2933, 3197, 3322, 3422, 3467, 3530, 3820], 'significantly': [139, 378, 2800, 2934, 3424, 3531, 4263], 'elevated': [140, 379, 3579, 3867], 'hyperoxia.': [142, 381, 2962, 3274], 'Under': [143, 382], 'normal': [144, 383, 2369, 3468, 4690], 'circumstances,': [145, 384], 'well': [148, 387, 768, 1765], 'known': [149, 388, 735, 1455, 2739], 'produced': [154, 393, 1391, 1820, 2624, 4342, 4490, 4619], 'at': [155, 176, 182, 394, 415, 421, 1708, 1821, 1846, 2112, 2241, 2282, 2298, 2627, 3482, 4343, 4469, 4491, 4581, 4620, 4656, 4661, 4723, 4868, 4919, 4951], 'complexes': [156, 183, 395, 422, 1465], 'I': [157, 184, 396, 423, 546, 1466, 1963, 2348, 2375, 5095], 'III': [159, 398, 580, 1468, 1965, 1973, 2083, 2629, 4345, 4471, 4681], 'system.': [164, 403], 'Our': [165, 404], 'data': [166, 211, 405, 450, 1800, 2420, 3343, 4289, 4316, 4597], 'suggest': [167, 406, 1802, 2421, 2604, 2845, 3344, 4571], 'increases': [172, 411, 4736], 'itself': [179, 418, 4584, 5226], 'rather': [180, 419, 2868, 3356, 4585], 'than': [181, 197, 420, 436, 1649, 1724, 2409, 2794, 2811, 2821, 2869, 2956, 3357, 3452, 4586, 4660, 4702], 'III.': [186, 425, 2444, 4593, 4663], 'The': [187, 426, 1362, 1389, 1567, 1959, 2094, 2115, 2127, 2159, 2247, 2276, 2288, 2394, 2574, 2702, 2774, 2913, 3489, 4503, 4532, 5247, 5263, 5330], 'also': [190, 225, 429, 464, 1367, 1631, 1801, 2406, 2964, 3221, 3876, 4706, 4746, 4939, 5146, 5315], 'had': [191, 430, 4638], 'lactate': [193, 432, 3438, 3580, 3614, 3868], 'level': [194, 433, 2775], '2-fold': [195, 434, 2713], 'higher': [196, 435, 2714, 2793, 2810, 2820, 2935, 3451, 4264], 'indicative': [200, 439], 'lactic': [202, 441, 641, 737, 1052, 3416, 5238], 'acidosis,': [203, 442, 642, 738], 'hallmark': [205, 444, 3187], 'human': [207, 446, 633, 1312, 5121, 5260], 'diseases.': [209, 448, 763, 5262], 'These': [210, 449, 600, 2843], 'indicate': [212, 451], 'Cyt-1/ceSDHC': [214, 453, 1359, 1535, 1770, 2458, 3244, 3396, 4813, 5244], 'plays': [215, 454, 1281], 'role': [218, 457, 1269, 1284, 1768], 'not': [219, 458, 788, 2415, 2465, 2592, 3314, 3423, 3845, 4743, 4933], 'only': [220, 459], 'energy': [222, 461, 3862, 5179], 'metabolism': [223, 462, 5180], 'but': [224, 463, 2379], 'critically': [232, 471], 'involved': [233, 472], 'sensitivity': [235, 474], 'coenzyme': [478], 'Q': [479, 564, 598, 2897, 4401, 4633], 'ubiquinone': [481], 'succinate': [482, 1274, 1294, 2063, 2788, 2905, 2918, 3465, 3527, 3570, 4693, 4739], 'dehydrogenase': [483, 1275], 'submitochondrial': [487], 'particles': [488, 1928], 'cypridina': [489], 'luciferin': [490, 2018], 'analog,': [491, 2019], '2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-α]pyrazin-3-one': [492], 'Mitochondria': [493, 1892, 3906, 5137], 'are': [494, 525, 559, 603, 729, 787, 1345, 2623, 2738, 3098, 3185, 3709, 3784, 3907, 4089, 4341, 4801, 5138, 5145, 5253, 5332], 'specialized': [495], 'organelles': [496], 'whose': [497], 'primary': [498], 'function': [499, 4999], 'synthesize': [502], 'ATP': [503, 2328, 2333, 3818, 3843, 3879, 3902, 5116], 'via': [504, 4893], 'oxidative': [505, 1397, 4092], 'phosphorylation': [506], 'aerobic': [508, 1393], 'eukaryotes': [509], '(1Saraste': [510, 5006], 'M.': [511, 705, 707, 793, 824, 826, 870, 985, 1055, 1086, 1088, 1547, 1585, 1659, 1734, 3006, 3008, 3063, 3065, 3370, 3372, 3534, 4104, 4155, 4235, 5007], 'Science.': [512, 680, 1243, 3131, 5008], '1999;': [513, 681, 694, 5009], '283:': [514, 682, 5010], '1488-1492Crossref': [515, 5011], 'PubMed': [516, 684, 697, 716, 812, 838, 864, 887, 913, 945, 965, 1004, 1074, 1100, 1154, 1174, 1247, 1260, 1415, 1428, 1448, 1477, 1497, 1562, 1600, 1624, 1665, 1688, 1749, 1911, 2004, 2638, 2651, 2671, 3019, 3035, 3076, 3122, 3135, 3383, 3553, 3938, 3958, 3999, 4012, 4032, 4046, 4119, 4143, 4161, 4184, 4250, 4354, 4367, 4387, 4837, 5012, 5025, 5038, 5058, 5072, 5132], 'Scopus': [517, 685, 717, 813, 839, 914, 946, 966, 1005, 1024, 1075, 1101, 1155, 1175, 1248, 1261, 1416, 1429, 1449, 1478, 1498, 1563, 1601, 1625, 1666, 1689, 1704, 1750, 2639, 2652, 2672, 3036, 3123, 3136, 3554, 3939, 3959, 4000, 4013, 4033, 4047, 4120, 4144, 4162, 4185, 4200, 4251, 4355, 4368, 4388, 4838, 5013, 5026, 5039, 5059, 5073, 5133], '(1039)': [518, 3037, 3124, 5014], 'Google': [519, 687, 698, 719, 815, 841, 865, 888, 916, 948, 968, 1007, 1026, 1077, 1103, 1157, 1177, 1250, 1263, 1418, 1431, 1451, 1480, 1500, 1565, 1603, 1627, 1668, 1691, 1706, 1752, 1912, 2005, 2641, 2654, 2674, 3020, 3038, 3077, 3125, 3138, 3384, 3556, 3941, 3961, 4002, 4015, 4035, 4049, 4122, 4146, 4164, 4187, 4202, 4253, 4357, 4370, 4390, 4840, 5015, 5028, 5041, 5061, 5075, 5135], 'Scholar).': [520, 720, 1027, 1104, 1178, 1264, 1452, 1501, 1566, 1628, 1753, 2006, 2211, 2675, 3039, 3078, 3139, 3385, 3557, 3962, 4050, 4203, 4254, 4391, 4841, 5076, 5136], 'During': [521], 'process,': [523], 'electrons': [524, 4424, 4523], 'transferred': [526, 560, 605], 'ultimately': [527, 3157, 5267], 'after': [530, 2087], 'passage': [532], 'through': [533, 543, 1306, 1315, 1360, 3404], 'four': [534, 1302], 'membrane-bound': [535], 'complexes.': [536], 'Electrons': [537], 'enter': [538], 'system': [542, 1365], 'either': [544, 1829, 2024, 2973, 3626], '(NADH-CoQ1': [547], 'oxidoreductase)': [548, 583, 1968, 1976], '(succinate-CoQ': [552], 'oxidoreductase).': [553], 'Via': [554], 'two,': [555], 'single-electron': [556, 3922], 'reductions,': [557], 'they': [558, 2737, 3976], 'CoQ': [562, 569], '(coenzyme': [563], 'ubiquinone),': [566], 'thereby': [567, 4888], 'reducing': [568, 601], 'first': [570, 2342, 4504, 5148], 'ubisemiquinone': [572, 4396, 4415], 'then': [574, 604, 2269, 2290], 'ubiquinol': [576, 586, 4413], '(dihydroubiquinone).': [577], 'At': [578], '(CoQH2-cytochrome': [581], 'c': [582, 619, 1721, 1967, 1975, 2372, 2385, 2486, 2490, 2501, 5092, 5099, 5106, 5111], 'molecules': [584], 'undergo': [587], 'two': [588, 5214], 'sequential': [589], 'spatially': [591], 'separate': [592], 'one-electron': [593], 'oxidations,': [594], 'process': [596, 5005], 'called': [597, 1042], 'cycle.': [599], 'equivalents': [602], 'remainder': [608], 'chain:': [613], 'c,': [615], 'IV': [617, 777], '(cytochrome': [618], 'oxidase),': [620], 'finally': [622], 'Mitochondrial': [625], 'deficiencies': [626], 'cause': [627, 1119, 1395, 5190], 'variety': [629, 754, 3341, 3972], 'diseases,': [631], 'including': [632, 3103], 'congenital': [634], 'neurodegenerative': [635, 3989], 'diseases': [636, 728, 1406, 3990, 5305], 'like': [637], 'MELAS': [638], '(mitochondrial': [639], 'encephalomyopathy,': [640], 'stroke-like': [644], 'episodes),': [645], 'MERRF': [646], '(myoclonic': [647], 'epilepsy': [648], 'with': [649, 1038, 1181, 1888, 1940, 2057, 2102, 2261, 2271, 2293, 2320, 2521, 2548, 2725, 3205, 3517, 3573, 3661, 3683, 3699, 3737, 3754, 3771, 3969, 4069, 4275, 4600, 4676, 4708, 4776, 4897, 5237, 5259, 5300], 'ragged': [650], 'red': [651], 'fibers),': [652], 'KSS': [653], '(Kearns-Sayre': [654], 'syndrome),': [655, 671], 'CPEO': [656], '(chronic': [657], 'progressive': [658], 'external': [659], 'ophthalmoplegia),': [660], 'NARP': [661], '(neuropathy,': [662], 'ataxia,': [663, 1124], 'retinitis': [665], 'pigmentosa),': [666], 'MILS': [667], '(maternally': [668], 'inherited': [669, 1183], 'Leigh': [670, 1043], 'LHON': [673], '(Leber': [674], 'hereditary': [675], 'optic': [676, 1122], 'neuropathy)': [677], '(2Wallace': [678], 'D.C.': [679, 1905, 1998], '1482-1488Crossref': [683], '(2631)': [686], 'Scholar,': [688, 699, 816, 842, 866, 889, 917, 949, 969, 1008, 1078, 1158, 1419, 1432, 1481, 1604, 1669, 1692, 2642, 2655, 3126, 3942, 4003, 4016, 4036, 4123, 4147, 4165, 4188, 4358, 4371, 5016, 5029, 5042, 5062], '3Howell': [689], 'N.': [690, 1541, 1551, 1579, 1589, 1606, 1655, 1673, 1698, 1728, 1738, 3000, 3057, 3364, 4098, 4108, 4125, 4151, 4169, 4194, 4229, 4239], 'Int.': [691], 'Rev.': [692, 4042, 5068], 'Cytol.': [693], '186:': [695], '49-116Crossref': [696], '4DiMauro': [700], 'S.': [701, 853, 1252, 1434, 1483, 1553, 1591, 1610, 1614, 1653, 1740, 2657, 3944, 4018, 4110, 4129, 4133, 4149, 4241, 4373, 5044, 5125], 'Bonilla': [702], 'E.': [703, 828, 977, 1090, 3010, 3067, 3374, 4792, 4808], 'Davidson': [704], 'Hirano': [706], 'Schon': [708], 'E.A.': [709], 'Biochim.': [710, 1409, 1471, 2632, 3932, 3993, 4348, 5019, 5126], 'Biophys.': [711, 1410, 1472, 2633, 3933, 3994, 4349, 5020, 5127], 'Acta.': [712, 1411, 1473, 2634, 3934, 3995, 4350, 5021, 5128], '1998;': [713, 1412, 1474, 1559, 1597, 1701, 1746, 2635, 3935, 3996, 4043, 4116, 4197, 4247, 4351, 4829, 5022, 5069], '1366:': [714, 1413, 1475, 2636, 3936, 3997, 4352, 5023], '199-210Crossref': [715], '(140)': [718], 'Many': [721, 4993], 'ultimate': [724], 'manifestations': [725, 2426], 'these': [727, 2419, 3266, 3308, 3605, 4288, 5157], 'triggered': [730], 'metabolic': [733, 757, 1048, 3289, 3359, 3606, 3894, 5235, 5248, 5256], 'imbalance': [734], 'which': [739, 2578, 3253, 4812], 'characterized': [741], 'high': [744, 1709, 4717], 'lactate/pyruvate': [745, 3412, 3444], 'ratio': [746, 3445, 3617], 'characteristic': [750], 'feature': [751], 'other': [756, 1332, 2828, 3512, 4659, 4677], 'disorders': [758], 'addition': [760, 1266, 2088, 4762], 'contrast': [765], 'defined': [769], 'pathologies': [770], 'resulting': [771, 3414], 'I,': [774], 'III,': [775], 'deficiencies,': [778], 'effects': [780, 2679, 3166], 'defects': [784, 1785, 3607], 'humans': [786], 'completely': [790, 1772], 'understood': [791], '(5Bourgeois': [792, 1054, 3533], 'Goutieres': [794, 1056, 3535], 'F.': [795, 1057, 1543, 1581, 1730, 3536, 4100, 4231], 'Chretien': [796, 821, 1058, 1083, 3537], 'D.': [797, 822, 1059, 1084, 1224, 1555, 1593, 1742, 3538, 4112, 4243, 4823], 'Rustin': [798, 819, 1060, 1081, 3539], 'P.': [799, 820, 937, 993, 1061, 1082, 1146, 1240, 3540], 'Munnich': [800, 829, 1062, 1091, 3541], 'A.': [801, 830, 832, 851, 1063, 1092, 1094, 1226, 1230, 3004, 3012, 3061, 3069, 3368, 3376, 3542], 'Aicardi': [802, 1064, 3543], 'J.': [803, 874, 904, 923, 998, 1065, 1132, 1660, 1699, 3014, 3024, 3026, 3028, 3030, 3071, 3111, 3113, 3115, 3117, 3378, 3544, 4156, 4195, 4826], 'Brain': [804, 1066, 3545], 'Dev.': [805, 1067, 1684, 3546, 4180], '1992;': [806, 1068, 3547], '14:': [807, 1069, 3548], '404-408Abstract': [808, 1070, 3549], 'Full': [809, 910, 1071, 1443, 1445, 1492, 1494, 2666, 2668, 3550, 3953, 3955, 4027, 4029, 4382, 4384, 4832, 4834, 5053, 5055], 'Text': [810, 911, 1072, 1444, 1446, 1493, 1495, 2667, 2669, 3551, 3954, 3956, 4028, 4030, 4383, 4385, 4833, 4835, 5054, 5056], 'PDF': [811, 912, 1073, 1447, 1496, 2670, 3552, 3957, 4031, 4386, 4836, 5057], '(70)': [814, 1076, 3555], '6Bourgeron': [817, 1079], 'T.': [818, 1080, 1421, 1612, 2644, 4005, 4131, 4360, 5031], 'Birch-Machin': [823, 920, 1085, 1129], 'Bourgeois': [825, 1087], 'Viegas-Pequignot': [827, 1089], 'Rotig': [831, 1093], 'Nat.': [833, 1095, 1255], 'Genet.': [834, 1096, 1256], '1995;': [835, 1097], '11:': [836, 1098], '144-149Crossref': [837, 1099], '(622)': [840, 1102], '7Riggs': [843], 'J.E.': [844, 1220], 'Schochet': [845], 'Jr.,': [846], 'S.S.': [847], 'Fakadej': [848], 'A.V.': [849], 'Papadimitriou': [850], 'DiMauro': [852], 'Crosby': [854], 'T.W.': [855], 'Gutmann': [856], 'L.': [857, 901, 925, 975, 1134, 4821], 'Moxley': [858], 'R.T.': [859], 'Neurology.': [860, 883], '1984;': [861], '34:': [862], '48-53Crossref': [863], '8Rivner': [867], 'M.H.': [868], 'Shamsnia': [869], 'Swift': [871], 'T.R.': [872], 'Trefz': [873], 'Roesel': [875], 'R.A.': [876, 2196], 'Carter': [877], 'A.L.': [878], 'Yanamura': [879], 'W.': [880], 'Hommes': [881], 'F.A.': [882], '1989;': [884], '39:': [885, 943, 1152], '693-696Crossref': [886], '9Martin': [890], 'J.J.': [891], 'Van-de-Vyver': [892], 'F.L.': [893], 'Scholte': [894], 'H.R.': [895], 'Roodhooft': [896], 'A.M.': [897], 'Ceuterick': [898], 'C.': [899, 1527, 3002, 3059, 3366, 4076], 'Martin': [900], 'Luyt-Houwen': [902], 'I.E.': [903], 'Neurol.': [905, 941, 961, 1150, 1170], 'Sci.': [906, 1439, 1488, 2662, 3949, 4023, 4378, 5049], '1988;': [907], '84:': [908], '189-200Abstract': [909], '(32)': [915], '10Taylor': [918], 'R.W.': [919, 953, 1128, 1162], 'M.A.': [921, 951, 1130, 1160], 'Schaefer': [922, 1131], 'Taylor': [924, 952, 1133, 1161], 'Shakir': [926, 1135], 'R.': [927, 979, 1136, 3130], 'Ackrell': [928, 956, 1137, 1165], 'B.A.': [929, 957, 1138, 1166], 'Cochran': [930, 954, 1139, 1163], 'B.': [931, 955, 1140, 1164, 1242], 'Bindoff': [932, 1141], 'L.A.': [933, 1142], 'Jackson': [934, 1143], 'M.J.': [935, 1144], 'Griffiths': [936, 1145], 'Turnbull': [938, 958, 1147, 1167], 'D.M.': [939, 959, 1148, 1168], 'Ann.': [940, 960, 1149, 1169], '1996;': [942, 1151, 1908, 2001, 3132, 5129], '224-232Crossref': [944, 1153], '(60)': [947, 1156], '11Birch-Machin': [950, 1159], '2000;': [962, 1171, 1244, 1257, 1425, 1440, 1489, 2648, 2663, 3032, 3119, 3950, 4009, 4024, 4364, 4379, 5035, 5050], '48:': [963, 1172, 1663, 4159], '330-335Crossref': [964, 1173], '(124)': [967, 1176], '12Haller': [970], 'R.G.': [971, 1016], 'Henriksson': [972, 1011], 'K.G.': [973, 1012], 'Jorfeldt': [974], 'Hultman': [976], 'Wibom': [978], 'Sahlin': [980], 'K.': [981, 987, 1549, 1557, 1587, 1595, 1608, 1616, 1618, 1657, 1677, 1681, 1736, 1744, 4106, 4114, 4127, 4135, 4137, 4153, 4173, 4177, 4237, 4245, 5359], 'Areskog': [982], 'N.H.': [983], 'Gunder': [984], 'Ayyad': [986], 'Blomqvist': [988], 'C.G.': [989], 'Hall': [990], 'R.E.': [991, 1010, 1218], 'Thuillier': [992], 'Kennaway': [994, 1017], 'N.G.': [995, 1018], 'Lewis': [996, 1013], 'S.F.': [997, 1014], 'Clin.': [999, 1019], 'Invest.': [1000, 1020], '1991;': [1001], '88:': [1002], '1197-1206Crossref': [1003], '(120)': [1006], '13Hall': [1009], 'Haller': [1015], '1993;': [1021, 1662, 4158], '92:': [1022], '2660-2666Crossref': [1023], '(80)': [1025], 'deficiency': [1031, 2582, 3245, 3393, 3805], 'has': [1032, 1114, 1530, 1717, 2380, 2591, 4205, 4788, 4858, 5170], 'been': [1033, 1116, 1194, 2593, 4206, 4789], 'described': [1034, 1520, 1990, 2192, 2233], 'associated': [1037, 5258], 'disease': [1041, 5354], 'syndrome': [1044], 'resulted': [1046, 3285], 'leading': [1050], 'acidosis': [1053, 5239], 'Another': [1105], 'flavoprotein': [1109, 1322], 'recently': [1115, 1195], 'late': [1120], 'onset': [1121], 'atrophy,': [1123], 'myopathy': [1126], '(10Taylor': [1127], 'Finally,': [1179], 'individuals': [1180], 'propensity': [1184], 'for': [1185, 1572, 1937, 2200, 2224, 2244, 2285, 2302, 2370, 2516, 2543, 2924, 2983, 3653, 3675, 3691, 3729, 3746, 3763, 3861, 4866, 4966, 5361], 'vascularized': [1186], 'head': [1187], 'neck': [1189], 'tumors': [1190], '(i.e.': [1191], 'paragangliomas)': [1192], 'demonstrated': [1196, 5080], 'contain': [1198], 'one': [1199, 3332], 'several': [1201], 'mutations': [1202, 4931], 'small': [1205, 1340], 'subunits': [1208, 1335, 1341], 'succinate-ubiquinone': [1213], 'oxidoreductase': [1214, 1722, 2373, 2386, 2398, 2487, 2491, 5093, 5100, 5107], '(14Baysal': [1215], 'B.E.': [1216], 'Ferrell': [1217], 'Willett-Brozick': [1219], 'Lawrence': [1221], 'E.C.': [1222], 'Myssiorek': [1223], 'Bosch': [1225], 'van': [1227], 'der': [1228], 'Mey': [1229], 'Taschner': [1231], 'P.E.M.': [1232], 'Rubinstein': [1233], 'W.S.': [1234], 'Myers': [1235], 'E.N.': [1236], 'Richard': [1237], 'C.W.': [1238], 'Devilee': [1239], 'Devlin': [1241], '287:': [1245], '848-851Crossref': [1246], '(1414)': [1249], 'Scholar,15Niemann': [1251], 'Muller': [1253], 'U.': [1254], '26:': [1258], '268-270Crossref': [1259], '(765)': [1262], 'its': [1268, 3508, 3810, 4563, 4894], 'transport,': [1272], '(SDH)': [1276], 'moiety': [1277, 3217], 'essential': [1283], 'trichloroacetic': [1287, 2257, 3406, 3496, 3595], 'acid': [1288, 2258, 3407, 3497, 3596, 4798, 4865], 'cycle,': [1289, 4402], 'catalyzing': [1290], 'conversion': [1292], 'fumarate.': [1296], 'Complex': [1297], 'composed': [1300], 'subunits,': [1303], 'named': [1304, 1346], 'SDHA': [1305], 'SDHD': [1307], 'Escherichia': [1309], 'coli': [1310, 4793, 4809], 'SDH1': [1314], 'SDH4': [1316], 'yeast.': [1318], 'SDHA/SDH1': [1319], 'subunit,': [1323], 'SDHB/SDH2': [1325], 'iron-sulfur': [1328], 'subunit.': [1330], 'Two': [1331, 4494], 'hydrophobic': [1333], 'membrane-anchored': [1334], '(consisting': [1336], 'b)': [1344], 'SDHC/SDH3/CybL': [1347], 'SDHD/SDH4/CybS.': [1349], 'will': [1351], 'refer': [1352], 'orthologs': [1357], 'ceSDHD.': [1361], 'major': [1369, 3912, 5140], 'source': [1371, 4684, 4753, 4985, 5141], '(ROS)': [1376], '(O⨪2),': [1381], 'hydrogen': [1382, 2754, 3086], 'peroxide': [1383, 3087], '(H2O2),': [1384], 'hydroxyl': [1386], 'radicals': [1387], '(⋅OH).': [1388], 'ROS': [1390, 2611, 2622, 2686, 2865, 2985, 2996, 3142, 3916, 3966, 4307, 5143, 5185, 5310], 'during': [1392, 4399], 'respiration': [1394], 'cumulative': [1396], 'results': [1400, 2844, 4464, 4538, 4576, 4606, 4715, 5268], 'age-related': [1404, 3093], 'degenerative': [1405], '(16Lenaz': [1407, 1469, 2630, 3930, 3991, 4346], 'G.': [1408, 1470, 2631, 3931, 3992, 4347, 5018], '53-67Crossref': [1414, 1476, 2637, 3937, 3998, 4353, 5024], '(569)': [1417, 1479, 2640, 3940, 4001, 4356, 5027], '17Finkel': [1420, 2643, 4004, 4359, 5030], 'Holbrook': [1422, 2645, 4006, 4361, 5032], 'N.J.': [1423, 2646, 4007, 4362, 5033], 'Nature.': [1424, 1558, 1596, 1745, 2647, 4008, 4115, 4246, 4363, 5034], '408:': [1426, 2649, 4010, 4365, 5036], '239-247Crossref': [1427, 2650, 4011, 4366, 5037], '(7425)': [1430, 2653, 4014, 4369, 5040], '18Raha': [1433, 1482, 2656, 3943, 4017, 4372, 5043], 'Robinson': [1435, 1484, 2658, 3945, 4019, 4374, 5045], 'B.H.': [1436, 1485, 2659, 3946, 4020, 4375, 5046], 'Trends': [1437, 1486, 2660, 3947, 4021, 4376, 5047], 'Biol.': [1438, 1487, 2661, 3948, 4022, 4377, 4827, 5048], '25:': [1441, 1490, 2664, 3951, 4025, 4380, 5051], '502-508Abstract': [1442, 1491, 2665, 3952, 4026, 4381, 5052], '(907)': [1450, 1499, 2673, 3960, 4034, 4389, 5060], 'It': [1453, 3386, 3601, 3850, 4333, 4938], 'initially': [1459], 'converted': [1460], 'Conversely,': [1502, 4664], 'there': [1503, 3432, 4517], 'no': [1505, 2598], 'evidence': [1506, 2363, 2599, 4570, 4678], 'site': [1512, 3914, 4926], 'production.': [1516, 2612, 2912, 4937], 'missense': [1532, 4210, 4860, 4917], '(19Ishii': [1540, 1578, 1727, 4097, 4228], 'Michikhiko': [1542, 1580, 1729, 4099, 4230], 'Hartman': [1544, 1582, 1731, 4101, 4232], 'P.S.': [1545, 1583, 1732, 4102, 4233], 'Tsuda': [1546, 1584, 1733, 4103, 4234], 'Yasuda': [1548, 1586, 1735, 4105, 4236], 'Senoo-Matsuda': [1550, 1588, 1737, 4107, 4238], 'Yanases': [1552, 1590, 1739, 4109, 4240], 'Ayusawa': [1554, 1592, 1741, 4111, 4242], 'Suzuki': [1556, 1594, 1617, 1656, 1680, 1743, 4113, 4136, 4152, 4176, 4244], '394:': [1560, 1598, 1747, 4117, 4248], '694-697Crossref': [1561, 1599, 1748, 4118, 4249], '(584)': [1564, 1602, 1751, 4121, 4252], 'mutant,': [1568], 'isolated': [1569, 1837, 1894, 1979, 3335], 'screening': [1571], 'oxygen,': [1575, 4427], 'ages': [1576], 'precociously': [1577, 4096], '20Ishii': [1605, 4124], 'Takahashi': [1607, 4126], 'Tomita': [1609, 4128], 'Keino': [1611, 4130], 'Honda': [1613, 4132], 'Koshino': [1615, 4134], 'Mutat.': [1619, 4138], 'Res.': [1620, 4139], '1990;': [1621, 4140], '237:': [1622, 4141], '165-171Crossref': [1623, 4142], '(181)': [1626, 4145], 'reported': [1632, 2530, 2564, 3716, 3791], 'accumulates': [1637], '(e.g.': [1641], 'carbonyls)': [1646, 5295], 'more': [1647, 2953, 3162, 3857, 4313, 4698, 4929], 'rapidly': [1648], 'type': [1651, 1726, 1831, 2413, 2518, 2545, 2727, 2797, 2814, 3207, 3428, 3456, 3663, 3685, 3701, 3739, 3756, 3773, 3825, 4672, 4704], '(21Honda': [1652], 'Ishii': [1654, 1672, 1697, 4150, 4168, 4193], 'Matsuo': [1658, 4154], 'Gerontol.': [1661, 1700, 4157, 4196], 'B57-B61Crossref': [1664, 4160], '(116)': [1667, 4163], '22Hosokawa': [1670, 4166], 'H.': [1671, 1675, 1679, 1694, 4167, 4171, 4175, 4190], 'Ishida': [1674, 4170], 'Ichimori': [1676, 4172], 'Nakazawa': [1678, 4174], 'Mech.': [1682, 4178], 'Ageing': [1683, 4179], '1994;': [1685, 4181], '74:': [1686, 4182], '161-170Crossref': [1687, 4183], '(91)': [1690, 4186], '23Adachi': [1693, 4189], 'Fujiwara': [1695, 4191], 'Y.': [1696, 4192], '53A:': [1702, 4198], 'B240-B244Crossref': [1703, 4199], '(142)': [1705, 4201], 'Scholar)': [1707, 1913], 'concentrations.': [1711], 'much': [1718, 2952, 3437], 'lower': [1719, 2408], 'succinate-cytochrome': [1720, 2384, 2489, 5098], 'activity': [1723, 2378, 2391, 2395, 2474, 4227], 'reason': [1756], 'hypersensitive': [1761, 3272, 4090], 'hyperoxia': [1763, 2765, 2803, 3631, 4270], 'was': [1771, 2010, 2069, 2085, 2096, 2133, 2329, 2405, 2792, 2799, 2808, 2837, 2920, 3230, 3313, 3433, 3449, 3474, 3815, 3844], 'unclear.': [1773], 'now': [1775, 4256], 'demonstrate': [1776, 4257, 4795], 'manifest': [1780, 5213], 'series': [1782, 4404], 'oxygen-hypersensitive': [1791, 3181], 'cellular': [1792, 2967, 3045, 3154, 3194, 3974, 5340], 'organismal': [1794, 4304, 5342], 'phenotypes.': [1796], 'that,': [1803], 'contrary': [1804], 'current': [1807], 'sentiment': [1808], 'scientific': [1811], 'literature,': [1812], 'significant': [1813, 3484, 3847], 'amounts': [1814, 3478], 'may': [1818, 3283, 3561, 3598, 4447, 4476, 4881, 4922], 'be': [1819, 2711, 2741, 3599, 4442, 4448, 4477, 4501, 4618, 4982, 5188, 5298], 'II.': [1823, 4493, 4725], 'To': [1824, 2676], 'prepare': [1825], 'stage-synchronized': [1826], '(N2:': [1832], 'Bristol': [1833], 'strain)': [1834], 'mev-1(kn1),': [1836], 'embryos': [1838], 'cultured': [1840, 2216, 2696], 'on': [1841, 2266, 2684, 2766, 3859, 4318, 4496, 4591, 4642, 5364], 'growth': [1843], 'medium': [1844], '(NGM)': [1845], '20': [1847, 1938], '°C': [1848], '(21%)': [1851, 2219, 3629], 'hyperoxic': [1853, 2221, 2700], '(40%)': [1854], 'conditions.': [1855, 2701, 4691], 'Young': [1856, 2212], 'adult': [1857, 1985, 2179, 2213], 'harvested': [1860], '72': [1861], 'h': [1862], 'later': [1863], 'centrifugation': [1865, 1897, 2240, 2281], 'homogenized': [1868, 2260], '(10%': [1869], 'w/v)': [1870], 'isolation': [1872, 1957], 'buffer': [1873, 1918, 2036], '(210': [1874], 'mm': [1875, 1880, 1884, 1920, 1923, 2038, 2046, 2062], 'mannitol,': [1876], '70': [1877], 'mmsucrose,': [1878], '0.1': [1879], 'EDTA,': [1881, 1921], '5': [1883], 'Tris-HCl,': [1885, 1924], 'pH': [1886, 1925, 2040], '7.4)': [1887], 'Teflon': [1890], 'homogenizer.': [1891], 'differential': [1896], '(24Trounce': [1898, 1991], 'I.A.': [1899, 1992], 'Kim': [1900, 1993], 'Y.L.': [1901, 1994], 'Jun': [1902, 1995], 'A.S.': [1903, 1996], 'Wallace': [1904, 1997], 'Methods': [1906, 1999, 2199], 'Enzymol.': [1907, 2000], '264:': [1909, 2002], '484-509Crossref': [1910, 2003], 'suspended': [1915, 1955, 2250], 'Tris-EDTA': [1917], '(0.1': [1919], '50': [1922], '7.4).': [1926], 'Submitochondrial': [1927], '(SMP)': [1929], 'obtained': [1931], 'sonicating': [1933], 'freeze-thawed': [1934], 'twice': [1936, 1953, 3435], 's': [1939], '1-min': [1941], 'intervals': [1942], 'model': [1945, 5200], 'U200S': [1946], 'sonicator': [1947], '(IKA': [1948, 2264], 'Labortechnik).': [1949], 'SMP': [1950, 2028, 2719, 2733], 'washed': [1952], 'buffer.': [1958], 'activities': [1960, 2345, 5085], 'plus': [1964, 1972, 2376, 2389, 5096, 5103], '(NADH-cytochrome': [1966], '(succinate-cytochrome': [1974], 'wild-type': [1981, 2175, 2353, 2460, 2493, 2694, 2835, 2925, 2955, 3234, 3621, 4956, 4974], 'young': [1984, 2178], 'measured': [1988, 2011, 2111, 2182, 2309, 2319, 2330, 2343, 2965], 'Superoxide': [2007], 'generation': [2009, 2054, 2863, 3088, 3903, 4543], 'using': [2012, 2310, 2331, 3324], 'chemiluminescent': [2014], 'probe': [2015], 'MCLA': [2016], '(cypridina': [2017], '2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-α]pyrazin-3-one).': [2020], 'Forty': [2021], 'micrograms': [2022], 'intact': [2025, 2716, 2771, 2781], 'added': [2030, 2070, 2086], '1': [2032], 'ml': [2033], 'assay': [2035, 2335], '(50': [2037], 'HEPES,': [2039], '7.4,': [2041], '2': [2042], 'mmEDTA)': [2043], 'containing': [2044], '0.5': [2045], 'MCLA.': [2047], 'For': [2048], 'measurement': [2050], 'substrate': [2058, 2068, 2982, 4965], 'inhibitor,': [2060], '1.5': [2061], 'solution,': [2074], '100': [2076], 'μm': [2077], 'antimycin': [2078, 2790, 2894, 2907, 2943, 4604, 4636, 4667, 4731], 'inhibitor': [2084, 2901, 4596, 4765], 'succinate.': [2093, 3576], 'solution': [2095], 'placed': [2097], 'into': [2098, 3593], 'photon': [2100], 'counter': [2101], 'H-R550': [2104], 'photomultiplier': [2105], '(Hamamatsu': [2106], 'Photogenic': [2107], 'Co.': [2108], 'Ltd.)': [2109], '37': [2113], '°C.': [2114], 'rates': [2116], 'expressed': [2122], 'counts': [2124], 'per': [2125, 2475], 'second.': [2126], 'amount': [2128], 'calculated': [2134], 'subtracting': [2136], 'optical': [2138], 'density': [2139], 'samples': [2141], 'presence': [2144], '10': [2146, 2245, 2286, 2303], 'μg/ml': [2147], 'bovine': [2148], 'Cu,Zn-superoxide': [2149, 2157], 'dismutase': [2150, 2747], 'absence': [2155], 'dismutase.': [2158], 'total': [2162, 2966, 3044, 3153, 3193, 3224], 'thiol': [2163, 3212, 3225], 'groups': [2164], '(total': [2165], 'SH)': [2166], 'reduced': [2168, 2383, 3277, 3477, 3506, 4277, 5001], '(GSH)': [2170], 'whole': [2172, 2228, 3329], 'lysates': [2173, 2229, 2236, 3330], 'rate': [2185, 3895], 'formation': [2187, 4892], '5,5′-dithio-(2-nitrobenzoic': [2189], 'acid)': [2190], '(25Anderson': [2193], 'A.E.': [2194], 'Greenwald': [2195], 'Handbook': [2197], 'Oxygen': [2201], 'Radical': [2202], 'Research.': [2203], 'CRC': [2204], 'Press,': [2205], 'Inc.,': [2206], 'Boca': [2207], 'Raton,': [2208], 'FL1985:': [2209], '317-323Google': [2210], '(50%)': [2222], 'conditions': [2223], '16': [2225], 'h,': [2226], 'prepared': [2231], 'below.': [2234], 'Animal': [2235], 'collected': [2238], '10,000': [2242, 2283, 2299], '×g': [2243, 2284], 'min.': [2246, 2287, 2304], 'pellets': [2248], 'equal': [2253, 2452], 'volume': [2254], '10%': [2256], 'ultra-Turrax': [2262], 'T8': [2263], 'Labortechnik)': [2265], 'ice': [2267], 'sonicated': [2270], 'Sonifier': [2273], '450': [2274], '(Branson).': [2275], 'homogenates': [2277], 'clarified': [2279], 'supernatants': [2289], 'neutralized': [2292], '4n': [2294], 'KOH': [2295], 'centrifuged': [2297], '×': [2300], 'g': [2301], 'Lactate': [2305], 'pyruvate': [2307, 3420, 3592, 3616], 'Sigma': [2311], 'diagnostic': [2312], 'kits.': [2313], 'Citrate,': [2314], 'succinate,': [2315, 2888, 4963], 'glutamate': [2317, 3473, 3492], 'enzymatic': [2322], 'bioanalysis/food': [2323], 'analysis': [2324, 3312], 'kit': [2325, 2336], '(Roche': [2326, 2339], 'Diagnostics).': [2327, 2340], 'bioluminescence': [2334], 'CLS': [2337], 'genetic': [2356, 2362], 'backgrounds': [2357], 'directly': [2359, 2594, 2609, 2975, 4525], 'confirm': [2360], 'NADH-cytochrome': [2371, 2485, 5091], '(complex': [2374, 2387, 2399, 2899, 5094, 5101, 5108, 5113, 5118], 'III)': [2377, 2390, 2900], 'severely': [2382], '(Table': [2392], 'I).': [2393], 'succinate-CoQ': [2397], 'II)': [2400], 'markedly': [2407], '(data': [2414, 2464], 'shown).': [2416], 'By': [2417], 'extension,': [2418], 'various': [2424, 3811], 'derive': [2431], 'defect': [2434, 3560, 4298, 4510], 'transfer': [2438], 'between': [2439], 'Because': [2445, 3210, 3963], 'Northern': [2446], 'Western': [2448], 'blots': [2449], 'revealed': [2450], 'roughly': [2451], 'mRNA': [2453], 'shown),': [2466], 'most': [2470, 4338, 4686, 4755], 'likely': [2471, 3241, 3852, 4802, 4905], 'compromises': [2472, 4224], 'enzyme': [2473, 2987], 'se': [2476], 'opposed': [2478], 'affecting': [2480], 'assembly.Table': [2482], 'IActivities': [2483], 'oxygenStrainNADH-cytochrome': [2499], 'coxidoreductaseSuccinate-cytochrome': [2500], 'oxidoreductasenmol': [2502], 'min−1': [2503], 'mg−1Wild': [2504], 'type312.8': [2505], '±': [2506, 2508, 2510, 2512, 2534, 2568, 3637, 3639, 3641, 3643, 3645, 3647, 3649, 3667, 3669, 3671, 3705, 3707, 3720, 3795], '84.140.2': [2507], '24.6mev-1306.6': [2509], '86.65.0': [2511], '1.8ap': [2513], '<': [2514, 2541, 3651, 3673, 3689, 3727, 3744, 3761], '0.05': [2515, 2542], 'compared': [2520, 2547, 2724, 3204, 3660, 3682, 3698, 3736, 3753, 3770], 'mutants': [2523, 2550, 2590, 3202, 3229, 3293, 3400, 3448, 3624, 3655, 3677, 3693, 3731, 3748, 3765, 3828, 4088, 4701, 5252, 5346], 'paired': [2525, 2552], "Student's": [2526, 2553], 't': [2527, 2554], 'test.Each': [2528], 'value': [2529, 2563, 3715, 3790], 'mean': [2533, 2567, 3719, 3794], 'S.D.': [2535, 2569, 3721, 3796], 'three': [2537, 2571, 3723, 3798], 'different': [2538, 2572, 3325, 3425, 3724, 3799], 'experiments.a': [2539, 3725], 'p': [2540, 3726, 3743, 3760], 'test.': [2555], 'Open': [2556, 3777], 'table': [2557, 3778], 'new': [2560, 3781], 'tab': [2561, 3782], 'Each': [2562, 3714, 3789], 'experiments.': [2573, 3800], 'specific': [2575, 4768], 'mechanism': [2576, 4063], 'addressed.': [2595], 'There': [2596], 'literature': [2602], 'contributes': [2608, 5272], 'Indeed,': [2613, 3192, 3418, 5159], 'currently': [2616, 5333], 'thought': [2617, 5316], 'majority': [2620], 'determine': [2677], 'production,': [2687], 'examined': [2689, 2761, 2879], 'found': [2709, 3049], 'approximately': [2712, 2921], '(Fig.': [2731, 2902, 3208, 3236, 3457, 3486, 3832, 3870, 4286, 4607], '1).': [2732], 'employed': [2735, 3328, 4790], 'because': [2736, 3316, 3885, 3918, 4544], 'depleted': [2742], '(MnSOD)': [2748], 'transforms': [2750], 'peroxide.': [2755], 'As': [2756, 4051, 4083], 'next': [2758], 'step,': [2759], 'effect': [2763, 4451, 4480, 4590, 4641], '(Fig.2).': [2773], '(without': [2784], 'stimulation': [2785, 2919], 'A)': [2791], 'increased': [2801, 2948, 3532, 4436, 4466, 4540, 4969], '(40%': [2804], 'O2).': [2805], 'Specifically,': [2806, 4392, 4627, 4785], '∼3.4-fold': [2809], '40%': [2816], 'O2': [2817, 3658, 3680, 3696, 3734, 3751, 3768], '∼1.6-fold': [2819, 3450], '21%': [2824, 3657, 3665, 3687, 3733, 3741, 3758], 'O2.': [2825, 3776], 'On': [2826, 3510], 'hand,': [2829, 3513], 'relatively': [2838], 'independent': [2839], 'concentration.': [2842], 'II-encoding': [2852], 'gene': [2853, 4214], 'cell': [2855, 3161, 5152, 5321], 'precocious': [2858, 3182, 4310, 5307], 'further': [2878], 'influenced': [2886], 'substrate,': [2892], 'A,': [2895], 'cycle': [2898, 3408, 3498, 3597, 4634], '2).': [2903, 4273], 'Both': [2904, 3462], 'stimulated': [2909, 4694], 'proportional': [2914], 'increase': [2915, 3081, 4446, 4475, 4521, 4669, 5183], 'same': [2923], 'mutants,': [2928, 2959, 3431, 3584], 'although': [2929, 3419], 'absolute': [2931], 'mutants.': [2938, 3191, 4760, 5204], 'inclusion': [2941], 'succinate-stimulated': [2946], 'particularly': [2960, 4268, 4623], 'GSH.': [2970], 'GSH': [2971, 3046, 3096, 3155, 3195, 3257, 3278, 3304, 3317, 3346, 4278], 'can': [2972, 4434, 4617], 'act': [2974, 3144], 'antioxidant': [2978], 'detoxifying': [2986], 'peroxidase': [2989], 'making': [2990], 'defense': [2994], 'against': [2995], '(26Fernandez-Checa': [2997, 3054, 3361], 'J.C.': [2998, 3055, 3362], 'Kaplowitz': [2999, 3056, 3363], 'Garcia-Ruiz': [3001, 3058, 3365], 'Colell': [3003, 3060, 3367], 'Miranda': [3005, 3062, 3369], 'Mari': [3007, 3064, 3371], 'Ardite': [3009, 3066, 3373], 'Morales': [3011, 3068, 3375], 'Am.': [3013, 3070, 3377], 'Physiol.': [3015, 3072, 3379, 4041, 5067], '1997;': [3016, 3073, 3380], '273:': [3017, 3074, 3133, 3381, 4830], 'G7-G17Crossref': [3018, 3075, 3382], 'Scholar,27Schultz': [3021], 'J.B.': [3022, 3109], 'Lindenau': [3023, 3110], 'Seyfreid': [3025, 3112], 'Dichgans': [3027, 3114], 'Eur.': [3029, 3116], 'Biochem.': [3031, 3118], '267:': [3033, 3120], '4904-4911Crossref': [3034, 3121], 'Only': [3040], '10–15%': [3041], 'normally': [3048], 'inside': [3050], 'matrix': [3053], 'An': [3079, 3558], 'age-associated': [3080], 'decline': [3094], 'observed': [3099, 4282], 'senescent': [3101], 'organisms': [3102], 'both': [3104, 3260, 3526], 'mammals': [3105], 'insects': [3107], '(27Schultz': [3108], '28Sohal': [3127], 'R.S.': [3128], 'Weindruch': [3129], '59-63Crossref': [3134], '(2640)': [3137], 'Elevated': [3140, 5309], 'could': [3143, 3174, 4500, 4511, 4551, 5187], 'sink': [3147], 'eventually': [3149], 'reduce': [3150], 'deplete': [3152], 'levels,': [3156], 'rendering': [3158], 'entire': [3160], 'susceptible': [3163], 'mitochondrially': [3168], 'generated': [3169, 3965, 4398], 'ROS.': [3170, 5158], 'This': [3171, 4204, 4842, 5193], 'turn': [3173, 3255], 'lead': [3175, 5318], 'dual': [3178], 'phenotypes': [3179, 3188, 4305], 'decreased': [3198, 3882], '∼30%': [3199], 'when': [3203], '3).': [3209, 3237], 'group': [3213], 'constitutes': [3214], 'GSH,': [3219], 'confirmed': [3222], 'experimentally': [3231, 3821], 'identical': [3232, 3822], 'Thus,': [3238], 'leads': [3246], 'ROS,': [3252], 'reduces': [3256], 'cytosol': [3261], 'concert': [3265], 'render': [3269], 'Alternatively,': [3275], 'extracts': [3282], 'some': [3287, 3887, 4458, 4657, 4945], 'unknown': [3288], 'versus': [3294], 'type.': [3296, 4992], 'stoichiometric': [3298], 'comparison': [3299], 'concentrations': [3305, 3421], 'would': [3306, 4932], 'distinguish': [3307], 'alternatives.': [3309], 'Such': [3310], 'attempted': [3315], 'assayed': [3323], 'protocols': [3326], 'case': [3333], 'another.': [3338], 'vary': [3348], 'response': [3351], 'scavenging': [3355], 'suppression': [3360], 'possible': [3388, 3603, 3877], 'might': [3401, 4949, 4980, 5297, 5347], 'impede': [3402], 'flow': [3403, 3590, 4514], 'alter': [3410], 'ratio,': [3413], 'acidosis.': [3417], 'over': [3434], 'animals,': [3441, 4267, 4651], 'i.e.': [3442], '4': [3458, 3487, 3833, 3871], 'TableII).': [3461], 'citrate': [3463], 'animals;': [3471], 'however,': [3472, 4602], 'present': [3475], 'statistically': [3483, 3846], 'B).': [3488], 'decrease': [3490, 3891, 5165, 5230], 'suggests': [3493, 3587, 4747, 4976], 'intermediate': [3499], 'α-ketoglutarate,': [3500], 'precursor': [3502], 'glutamate,': [3504], 'content.': [3509], 'patient': [3516], 'SDH': [3521, 3559], 'defects,': [3522], 'urine': [3523], 'α-ketoglutarate': [3529], 'result': [3562, 4552, 4882], 'block': [3565], 'oxidation': [3568, 4411], 'fumarate': [3572], 'Given': [3577, 3801, 4431], 'finding': [3586], 'reduced.': [3600], 'contribute': [3608], 'phenotypes.Table': [3612], 'IIThe': [3613], '(L/P': [3618], 'ratio)': [3619], '(50%)StrainOxygen': [3632], 'concentrationsLactatePyruvateL/P': [3633], 'ratio%mmol': [3634], 'liter−1Wild': [3635], 'type211.28': [3636], '0.440.040': [3638], '0.02235.7': [3640], '16.8501.37': [3642], '0.370.046': [3644], '0.02131.7': [3646], '5.9mev-1212.97': [3648], '0.16ap': [3650], '0.005': [3652, 3674, 3690, 3728, 3745, 3762], 'O2.0.056': [3666], '0.02258.0': [3668], '20.9503.17': [3670], '0.06bp': [3672], '50%': [3679, 3695, 3703, 3750, 3767, 3775, 3837], 'O2.cp': [3688], 'O2.0.049': [3704], '0.02575.7': [3706], '32.6Data': [3708], 'Fig.': [3712, 3787], '3.': [3713, 3788], 'O2.b': [3742], 'O2.c': [3759], 'Data': [3783], 'consequences,': [3813], 'surprising': [3816], 'C).': [3834, 3849], 'Even': [3835], 'slight': [3840], '(Fig.4': [3848], 'seems': [3851, 4874, 4904, 4940], 'rely': [3856], 'heavily': [3858], 'glycolysis': [3860], 'acquisition,': [3863], 'thus': [3864], 'explaining': [3865], 'A).': [3872], 'consumption': [3880], 'sort': [3888], 'global': [3890], 'acts': [3897], 'counterbalance': [3899], 'compromised': [3901], 'mev-1animals.': [3905], 'widely': [3908], 'accepted': [3909], 'intracellular': [3913], 'inappropriate': [3921], 'diatomic': [3925, 4426], 'once': [3964], 'react': [3967], 'indiscriminately': [3968], 'wide': [3971], 'constituents,': [3975], 'figure': [3977], 'prominently': [3978], 'theories': [3980], 'seeking': [3981], 'etiology': [3985], '29Beckman': [4037, 5063], 'K.B.': [4038, 5064], 'Ames': [4039, 5065], 'B.N.': [4040, 5066], '78:': [4044, 5070], '547-581Crossref': [4045, 5071], '(3156)': [4048, 5074], 'such,': [4052], 'understand': [4057], 'precise': [4059], 'location': [4061, 4658], 'generation.': [4067], 'Work': [4068], 'elegansmay': [4077], 'prove': [4078], 'useful': [4079], 'regard.': [4082], 'articulated': [4084], 'Introduction,mev-1': [4087], 'stress': [4093], 'age': [4095], '21Honda': [4148], 'attributed': [4207], 'encoding': [4215], 'Cyt-1/ceSDH3,': [4216], 'b,': [4222], '(Figs.1': [4271], 'Along': [4274], '3),': [4287], 'provide': [4290], 'connection': [4293], 'links': [4295], 'molecular': [4297, 4530, 4898], 'aging.': [4311, 5192, 5308, 5356], 'Perhaps': [4312], 'importantly,': [4314], 'bear': [4317], 'question': [4320], 'precisely': [4322], 'where': [4323], 'how': [4328, 4433], 'generated.': [4332], 'generally': [4335], 'believed': [4336], 'anions': [4340, 4688], 'free': [4394, 4559], 'radical': [4395, 4560], 'events': [4406], 'includes': [4408], 'two-step': [4410], 'ubiquinone.': [4417], 'Ubisemiquinone': [4418], 'alternatively': [4420], 'capable': [4421], 'transferring': [4423], 'forming': [4428], 'anion.': [4430, 4784], 'this,': [4432], 'explained?': [4443], 'First,': [4444], 'indirect': [4450, 4589], 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[4734], 'mediated': [4737], '(but': [4742], 'type)': [4745], 'data,': [4766], 'nature': [4769], 'direct,': [4778], 'II-mediated': [4780], 'site-directed': [4786], 'mutagenesis': [4787], 'amino': [4797, 4845], 'residues': [4799], '17–33': [4800], 'ubiquinone-binding': [4804], 'sites': [4805], 'SDHC': [4810], 'ortholog': [4817], '(30Yang': [4818], 'X.,': [4819], 'Yu,': [4820], 'He': [4822], 'Yu': [4824], 'C.A.': [4825], 'Chem.': [4828], '31916-31923Abstract': [4831], '(49)': [4839], 'corresponds': [4843], 'acids': [4846], '59–76': [4847], 'Cyt-1/ceSDHC.': [4849], 'substitutes': [4863], 'glutamic': [4864], 'glycine': [4867], 'residue': [4869], '71': [4870, 4921], '(19).': [4871], 'Therefore,': [4872, 5336], 'reasonable': [4875, 4941], 'speculate': [4877], 'semiquinone,': [4887], 'enabling': [4889], 'subsequent': [4895], 'interaction': [4896], 'Whatever': [4900], 'case,': [4902], 'exerts': [4910], 'allele-specific': [4912], 'effect,': [4913], 'position': [4920], 'quinone-binding': [4925], 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