Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2163209521', 'doi': 'https://doi.org/10.1172/jci25247', 'title': 'P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model', 'display_name': 'P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model', 'publication_year': 2005, 'publication_date': '2005-10-26', 'ids': {'openalex': 'https://openalex.org/W2163209521', 'doi': 'https://doi.org/10.1172/jci25247', 'mag': '2163209521', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16239972', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1257538'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci25247', 'pdf_url': 'http://www.jci.org/articles/view/25247/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/25247/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086615705', 'display_name': 'John R. Cirrito', 'orcid': 'https://orcid.org/0000-0002-7196-8786'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'J. R. Cirrito', 'raw_affiliation_strings': ['Department of Neurology, Washington University Medical School, St. Louis, Missouri, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Washington University Medical School, St. Louis, Missouri, USA.', 'institution_ids': ['https://openalex.org/I204465549']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5086615705'], 'corresponding_institution_ids': ['https://openalex.org/I204465549'], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 9.392, 'has_fulltext': False, 'cited_by_count': 609, 'citation_normalized_percentile': {'value': 0.999925, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '115', 'issue': '11', 'first_page': '3285', 'last_page': '3290'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.6435118}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.44559363}], 'concepts': [{'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.7858968}, {'id': 'https://openalex.org/C2778402981', 'wikidata': 'https://www.wikidata.org/wiki/Q221694', 'display_name': 'Blood–brain barrier', 'level': 3, 'score': 0.7265128}, {'id': 'https://openalex.org/C2778707650', 'wikidata': 'https://www.wikidata.org/wiki/Q412902', 'display_name': 'P-glycoprotein', 'level': 4, 'score': 0.6435118}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.64327455}, {'id': 'https://openalex.org/C31705614', 'wikidata': 'https://www.wikidata.org/wiki/Q423510', 'display_name': 'Amyloid precursor protein', 'level': 4, 'score': 0.5258561}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.5010822}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47988546}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.44918215}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.44559363}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.44129395}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42503437}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.42434}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.4197339}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33478546}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.3119654}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.31134838}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.22600845}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.22456542}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.20355007}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1539396}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.051677227}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020168', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D001812', 'descriptor_name': 'Blood-Brain Barrier', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci25247', 'pdf_url': 'http://www.jci.org/articles/view/25247/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1257538', 'pdf_url': 'https://europepmc.org/articles/pmc1257538?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257538', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16239972', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci25247', 'pdf_url': 'http://www.jci.org/articles/view/25247/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1580500775', 'https://openalex.org/W1580552411', 'https://openalex.org/W1594119953', 'https://openalex.org/W1744830941', 'https://openalex.org/W1841389452', 'https://openalex.org/W1966874118', 'https://openalex.org/W1981554609', 'https://openalex.org/W1997822484', 'https://openalex.org/W2001210466', 'https://openalex.org/W2006434892', 'https://openalex.org/W2025944561', 'https://openalex.org/W2041851050', 'https://openalex.org/W2054458932', 'https://openalex.org/W2058614488', 'https://openalex.org/W2059841300', 'https://openalex.org/W2063291817', 'https://openalex.org/W2066245354', 'https://openalex.org/W2069608336', 'https://openalex.org/W2076517751', 'https://openalex.org/W2090097368', 'https://openalex.org/W2098142549', 'https://openalex.org/W2107233754', 'https://openalex.org/W2108842980', 'https://openalex.org/W2112001901', 'https://openalex.org/W2118569739', 'https://openalex.org/W2129337589', 'https://openalex.org/W2147044481', 'https://openalex.org/W2157152668', 'https://openalex.org/W2163636362', 'https://openalex.org/W2319697195', 'https://openalex.org/W2614921709', 'https://openalex.org/W4232195096', 'https://openalex.org/W4239000258', 'https://openalex.org/W4255010805'], 'related_works': ['https://openalex.org/W66351836', 'https://openalex.org/W2399682742', 'https://openalex.org/W2141236507', 'https://openalex.org/W2090871024', 'https://openalex.org/W2058440606', 'https://openalex.org/W2057488004', 'https://openalex.org/W2046826638', 'https://openalex.org/W2031291688', 'https://openalex.org/W2013205211', 'https://openalex.org/W1883303029'], 'abstract_inverted_index': {'Accumulation': [0], 'of': [1, 7, 13, 41, 48, 71, 127, 136], 'amyloid-beta': [2], '(Abeta)': [3], 'within': [4, 118, 125], 'extracellular': [5], 'spaces': [6], 'the': [8, 34, 51, 60, 68, 79, 92, 97, 119, 168], 'brain': [9, 35, 72, 120, 137], 'is': [10, 22, 64], 'a': [11, 113, 152, 180], 'hallmark': [12], 'Alzheimer': [14], 'disease': [15], '(AD).': [16], 'In': [17, 81], 'sporadic,': [18], 'late-onset': [19], 'AD,': [20], 'there': [21], 'little': [23], 'evidence': [24], 'for': [25, 173], 'increased': [26, 124, 134], 'Abeta': [27, 42, 49, 57, 116, 138, 141, 158], 'production,': [28], 'suggesting': [29], 'that': [30, 86, 99, 164], 'decreased': [31], 'elimination': [32], 'from': [33, 59], 'may': [36], 'contribute': [37], 'to': [38, 56, 78], 'elevated': [39], 'levels': [40, 117, 135], 'and': [43, 76, 88, 139, 157, 162, 183], 'plaque': [44], 'formation.': [45], 'Efflux': [46], 'transport': [47], 'across': [50], 'blood-brain': [52], 'barrier': [53], '(BBB)': [54], 'contributes': [55, 77], 'removal': [58], 'brain.': [61], 'P-glycoprotein': [62], '(Pgp)': [63], 'highly': [65], 'expressed': [66], 'on': [67], 'luminal': [69], 'surface': [70], 'capillary': [73], 'endothelial': [74], 'cells': [75], 'BBB.': [80], 'Pgp-null': [82, 131], 'mice,': [83], 'we': [84], 'show': [85], '[I]Abeta40': [87], '[I]Abeta42': [89], 'microinjected': [90], 'into': [91], 'CNS': [93], 'clear': [94], 'at': [95, 167], 'half': [96], 'rate': [98], 'they': [100], 'do': [101], 'in': [102, 160], 'WT': [103, 147], 'mice.': [104, 148], 'When': [105], 'amyloid': [106], 'precursor': [107], 'protein-transgenic': [108], '(APP-transgenic)': [109], 'mice': [110, 132], 'were': [111], 'administered': [112], 'Pgp': [114, 146, 156, 165], 'inhibitor,': [115], 'interstitial': [121], 'fluid': [122], 'significantly': [123], 'hours': [126], 'treatment.': [128], 'Furthermore,': [129], 'APP-transgenic,': [130, 145], 'had': [133], 'enhanced': [140], 'deposition': [142], 'compared': [143], 'with': [144], 'These': [149], 'data': [150], 'establish': [151], 'direct': [153], 'link': [154], 'between': [155], 'metabolism': [159], 'vivo': [161], 'suggest': [163], 'activity': [166], 'BBB': [169], 'could': [170], 'affect': [171], 'risk': [172], 'developing': [174], 'AD': [175], 'as': [176, 178], 'well': [177], 'provide': [179], 'novel': [181], 'diagnostic': [182], 'therapeutic': [184], 'target.': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2163209521', 'counts_by_year': [{'year': 2024, 'cited_by_count': 26}, {'year': 2023, 'cited_by_count': 36}, {'year': 2022, 'cited_by_count': 31}, {'year': 2021, 'cited_by_count': 26}, {'year': 2020, 'cited_by_count': 37}, {'year': 2019, 'cited_by_count': 30}, {'year': 2018, 'cited_by_count': 28}, {'year': 2017, 'cited_by_count': 34}, {'year': 2016, 'cited_by_count': 43}, {'year': 2015, 'cited_by_count': 40}, {'year': 2014, 'cited_by_count': 43}, {'year': 2013, 'cited_by_count': 44}, {'year': 2012, 'cited_by_count': 26}], 'updated_date': '2024-12-17T07:58:37.875723', 'created_date': '2016-06-24'}