Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2162708395', 'doi': 'https://doi.org/10.1128/aac.46.1.216-219.2002', 'title': 'Postneurosurgical Meningitis Due to <i>Proteus penneri</i> with Selection of a Ceftriaxone-Resistant Isolate: Analysis of Chromosomal Class A β-Lactamase HugA and its LysR-Type Regulatory Protein HugR', 'display_name': 'Postneurosurgical Meningitis Due to <i>Proteus penneri</i> with Selection of a Ceftriaxone-Resistant Isolate: Analysis of Chromosomal Class A β-Lactamase HugA and its LysR-Type Regulatory Protein HugR', 'publication_year': 2002, 'publication_date': '2002-01-01', 'ids': {'openalex': 'https://openalex.org/W2162708395', 'doi': 'https://doi.org/10.1128/aac.46.1.216-219.2002', 'mag': '2162708395', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11751137', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/126972'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.46.1.216-219.2002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc126972?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5021456818', 'display_name': 'Nadia Liassine', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106256', 'display_name': 'University Hospital of Geneva', 'ror': 'https://ror.org/01m1pv723', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106256']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Nadia Liassine', 'raw_affiliation_strings': ['Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland', 'institution_ids': ['https://openalex.org/I4210106256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035856195', 'display_name': 'Stéphanie Madec', 'orcid': 'https://orcid.org/0000-0002-4684-7931'}, 'institutions': [{'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}], 'countries': ['MA'], 'is_corresponding': False, 'raw_author_name': 'Stéphanie Madec', 'raw_affiliation_strings': ['Centre National de la Recherche Scientifique, Unité FRE 2125, Quimper'], 'affiliations': [{'raw_affiliation_string': 'Centre National de la Recherche Scientifique, Unité FRE 2125, Quimper', 'institution_ids': ['https://openalex.org/I4210089144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033857070', 'display_name': 'Béatrice Ninet', 'orcid': 'https://orcid.org/0000-0003-3575-2483'}, 'institutions': [{'id': 'https://openalex.org/I4210106256', 'display_name': 'University Hospital of Geneva', 'ror': 'https://ror.org/01m1pv723', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106256']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Béatrice Ninet', 'raw_affiliation_strings': ['Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland', 'institution_ids': ['https://openalex.org/I4210106256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036865386', 'display_name': 'Catherine Metral', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106256', 'display_name': 'University Hospital of Geneva', 'ror': 'https://ror.org/01m1pv723', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106256']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Catherine Metral', 'raw_affiliation_strings': ['Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland', 'institution_ids': ['https://openalex.org/I4210106256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057482656', 'display_name': 'Martine Fouchereau‐Péron', 'orcid': None}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Martine Fouchereau-Peron', 'raw_affiliation_strings': ['Centre de Biologie Marine, Unité FRE 2125, Concarneau, France'], 'affiliations': [{'raw_affiliation_string': 'Centre de Biologie Marine, Unité FRE 2125, Concarneau, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022157667', 'display_name': 'Roger Labia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}], 'countries': ['MA'], 'is_corresponding': False, 'raw_author_name': 'Roger Labia', 'raw_affiliation_strings': ['Centre National de la Recherche Scientifique, Unité FRE 2125, Quimper'], 'affiliations': [{'raw_affiliation_string': 'Centre National de la Recherche Scientifique, Unité FRE 2125, Quimper', 'institution_ids': ['https://openalex.org/I4210089144']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020164304', 'display_name': 'R Auckenthaler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106256', 'display_name': 'University Hospital of Geneva', 'ror': 'https://ror.org/01m1pv723', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106256']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Raymond Auckenthaler', 'raw_affiliation_strings': ['Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland', 'institution_ids': ['https://openalex.org/I4210106256']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5021456818'], 'corresponding_institution_ids': ['https://openalex.org/I4210106256'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.391, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.480061, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '46', 'issue': '1', 'first_page': '216', 'last_page': '219'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Genetics and Biotechnology', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10654', 'display_name': 'Pneumonia and Respiratory Infections', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776520383', 'wikidata': 'https://www.wikidata.org/wiki/Q421713', 'display_name': 'Ceftriaxone', 'level': 3, 'score': 0.7299477}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6715124}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.62042}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.26550144}], 'mesh': [{'descriptor_ui': 'D016920', 'descriptor_name': 'Meningitis, Bacterial', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D011183', 'descriptor_name': 'Postoperative Complications', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D011511', 'descriptor_name': 'Proteus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002443', 'descriptor_name': 'Ceftriaxone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002443', 'descriptor_name': 'Ceftriaxone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002876', 'descriptor_name': 'Chromosomes, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016920', 'descriptor_name': 'Meningitis, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011183', 'descriptor_name': 'Postoperative Complications', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011511', 'descriptor_name': 'Proteus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011511', 'descriptor_name': 'Proteus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D011511', 'descriptor_name': 'Proteus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.46.1.216-219.2002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc126972', 'pdf_url': 'https://europepmc.org/articles/pmc126972?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC126972', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11751137', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc126972', 'pdf_url': 'https://europepmc.org/articles/pmc126972?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1578263736', 'https://openalex.org/W1581962345', 'https://openalex.org/W1959680767', 'https://openalex.org/W1999956197', 'https://openalex.org/W2004590671', 'https://openalex.org/W2033714109', 'https://openalex.org/W2041215841', 'https://openalex.org/W2041893228', 'https://openalex.org/W2047037520', 'https://openalex.org/W2057693404', 'https://openalex.org/W2098954806', 'https://openalex.org/W2101418660', 'https://openalex.org/W2104611141', 'https://openalex.org/W2115003030', 'https://openalex.org/W2121867408', 'https://openalex.org/W2134352676', 'https://openalex.org/W2145061189', 'https://openalex.org/W2160129121', 'https://openalex.org/W2161236679', 'https://openalex.org/W2399996023', 'https://openalex.org/W4244214976'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W2788277189', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2082860237', 'https://openalex.org/W2046158694', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418', 'https://openalex.org/W1971568933'], 'abstract_inverted_index': {'ABSTRACT': [0], 'We': [1], 'report': [2], 'on': [3], 'a': [4, 7, 19, 37], 'case': [5], 'of': [6, 18, 46, 58, 64, 87], 'postneurosurgical': [8], 'meningitis': [9], 'due': [10], 'to': [11, 95, 105], 'ceftriaxone-susceptible': [12], 'Proteus': [13, 88], 'penneri': [14, 79], ',': [15, 73], 'with': [16, 24, 42, 85], 'selection': [17], 'ceftriaxone-resistant': [20, 49], 'isolate': [21, 50], 'following': [22], 'treatment': [23], 'ceftriaxone.': [25], 'The': [26, 48, 62, 91], 'isolates': [27], 'presented': [28], 'identical': [29, 75], 'patterns': [30], 'by': [31], 'pulsed-field': [32], 'gel': [33], 'electrophoresis': [34], 'and': [35, 69, 81, 99], 'produced': [36], 'single': [38], 'β-lactamase': [39, 53, 67, 93], 'named': [40], 'HugA': [41, 92], 'an': [43], 'isoelectric': [44], 'point': [45], '6.7.': [47], 'hyperproduced': [51], 'the': [52, 56, 65, 100, 106], '(increase': [54], 'in': [55, 76], 'level': [57], 'production,': [59], 'about': [60], '90-fold).': [61], 'sequences': [63], 'hugA': [66], 'gene': [68], 'its': [70], 'regulator,': [71], 'hugR': [72], 'were': [74], 'both': [77], 'P.': [78], 'strains': [80], 'had': [82], '85.96%': [83], 'homology': [84], 'those': [86], 'vulgaris': [89], '.': [90], 'belongs': [94, 104], 'molecular': [96], 'class': [97], 'A,': [98], 'transcriptional': [101], 'regulator': [102], 'HugR': [103], 'LysR': [107], 'family.': [108]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162708395', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-09T07:35:31.411728', 'created_date': '2016-06-24'}