Publication Information

{'id': 'https://openalex.org/W2162574319', 'doi': 'https://doi.org/10.1242/jcs.031682', 'title': 'Control of mitochondrial apoptosis by the Bcl-2 family', 'display_name': 'Control of mitochondrial apoptosis by the Bcl-2 family', 'publication_year': 2009, 'publication_date': '2009-02-04', 'ids': {'openalex': 'https://openalex.org/W2162574319', 'doi': 'https://doi.org/10.1242/jcs.031682', 'mag': '2162574319', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19193868', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2714431'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.031682', 'pdf_url': 'https://journals.biologists.com/jcs/article-pdf/122/4/437/1494003/437.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.biologists.com/jcs/article-pdf/122/4/437/1494003/437.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020205427', 'display_name': 'Joslyn K. Brunelle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joslyn K. Brunelle', 'raw_affiliation_strings': ['Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5022857112', 'display_name': 'Anthony Letai', 'orcid': 'https://orcid.org/0000-0002-1993-9013'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Anthony Letai', 'raw_affiliation_strings': ['Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5022857112'], 'corresponding_institution_ids': ['https://openalex.org/I4210117453'], 'apc_list': None, 'apc_paid': None, 'fwci': 6.043, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 871, 'citation_normalized_percentile': {'value': 0.999699, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '122', 'issue': '4', 'first_page': '437', 'last_page': '441'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9674, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bcl-2-family', 'display_name': 'Bcl-2 Family', 'score': 0.726061}, {'id': 'https://openalex.org/keywords/intrinsic-apoptosis', 'display_name': 'Intrinsic apoptosis', 'score': 0.45366648}, {'id': 'https://openalex.org/keywords/bcl-2-associated-x-protein', 'display_name': 'Bcl-2-associated X protein', 'score': 0.4455637}, {'id': 'https://openalex.org/keywords/protein-family', 'display_name': 'Protein family', 'score': 0.41855395}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.87280333}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7364378}, {'id': 'https://openalex.org/C149150037', 'wikidata': 'https://www.wikidata.org/wiki/Q554446', 'display_name': 'Bcl-2 family', 'level': 4, 'score': 0.726061}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.72459495}, {'id': 'https://openalex.org/C2778944004', 'wikidata': 'https://www.wikidata.org/wiki/Q91703', 'display_name': 'Caenorhabditis elegans', 'level': 3, 'score': 0.69984615}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.6631408}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.66172075}, {'id': 'https://openalex.org/C163421366', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Intrinsic apoptosis', 'level': 5, 'score': 0.45366648}, {'id': 'https://openalex.org/C2780362710', 'wikidata': 'https://www.wikidata.org/wiki/Q408476', 'display_name': 'Bcl-2-associated X protein', 'level': 5, 'score': 0.4455637}, {'id': 'https://openalex.org/C171897839', 'wikidata': 'https://www.wikidata.org/wiki/Q417841', 'display_name': 'Protein family', 'level': 3, 'score': 0.41855395}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.29506308}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.28716773}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2586093}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.08138472}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D051336', 'descriptor_name': 'Mitochondrial Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051336', 'descriptor_name': 'Mitochondrial Membranes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.031682', 'pdf_url': 'https://journals.biologists.com/jcs/article-pdf/122/4/437/1494003/437.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2714431', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714431', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19193868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.031682', 'pdf_url': 'https://journals.biologists.com/jcs/article-pdf/122/4/437/1494003/437.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W103053889', 'https://openalex.org/W1607777232', 'https://openalex.org/W1616121322', 'https://openalex.org/W1913661233', 'https://openalex.org/W1973363947', 'https://openalex.org/W1976720365', 'https://openalex.org/W1981166298', 'https://openalex.org/W1984547206', 'https://openalex.org/W1985563073', 'https://openalex.org/W1988917342', 'https://openalex.org/W1994811047', 'https://openalex.org/W1995775226', 'https://openalex.org/W1999197294', 'https://openalex.org/W2002919668', 'https://openalex.org/W2008376982', 'https://openalex.org/W2008715871', 'https://openalex.org/W2008841394', 'https://openalex.org/W2009183764', 'https://openalex.org/W2012076962', 'https://openalex.org/W2024996523', 'https://openalex.org/W2026873116', 'https://openalex.org/W2032049833', 'https://openalex.org/W2033873142', 'https://openalex.org/W2038764386', 'https://openalex.org/W2059666350', 'https://openalex.org/W2062547838', 'https://openalex.org/W2062853648', 'https://openalex.org/W2064937772', 'https://openalex.org/W2073571990', 'https://openalex.org/W2082293892', 'https://openalex.org/W2085419794', 'https://openalex.org/W2093628776', 'https://openalex.org/W2094052642', 'https://openalex.org/W2097007474', 'https://openalex.org/W2097290512', 'https://openalex.org/W2116177527', 'https://openalex.org/W2126376871', 'https://openalex.org/W2130866079', 'https://openalex.org/W2134872883', 'https://openalex.org/W2134979684', 'https://openalex.org/W2143772496', 'https://openalex.org/W2147318282', 'https://openalex.org/W2150315067', 'https://openalex.org/W2160345685', 'https://openalex.org/W2168632005', 'https://openalex.org/W35060329'], 'related_works': ['https://openalex.org/W2972417636', 'https://openalex.org/W2914973623', 'https://openalex.org/W2769631482', 'https://openalex.org/W2743954912', 'https://openalex.org/W2381038151', 'https://openalex.org/W2182578372', 'https://openalex.org/W2057585964', 'https://openalex.org/W2016712019', 'https://openalex.org/W1995074959', 'https://openalex.org/W1978318402'], 'abstract_inverted_index': {'Programmed': [0], 'cell': [1, 16, 27, 320, 335, 454, 837, 1151, 1222, 2058, 2069, 2246], 'death,': [2, 573], 'or': [3, 23, 38, 167, 193, 223, 313, 365, 591, 663, 942, 1278, 1403, 1810, 1823, 2070, 2175], 'apoptosis,': [4, 293], 'is': [5, 118, 148, 150, 392, 560, 786, 807, 862, 906, 980, 999, 1008, 1020, 1044, 1143, 1145, 1218, 1260, 1265, 1320, 1557, 1573, 1605, 1659, 1726, 1740, 1747, 1867, 1955, 2118, 2133, 2261, 2276], 'important': [6, 603, 1657, 2049, 2305, 2324, 2330], 'for': [7, 388, 405, 464, 543, 604, 734, 1046, 1220, 1361, 1470, 1791, 1957, 2031, 2190, 2294, 2339], 'the': [8, 36, 58, 90, 125, 155, 161, 172, 179, 182, 198, 213, 216, 228, 238, 243, 272, 289, 304, 308, 346, 380, 442, 516, 520, 524, 529, 532, 551, 610, 640, 672, 766, 846, 860, 863, 867, 940, 946, 959, 964, 983, 996, 1002, 1014, 1017, 1024, 1086, 1092, 1095, 1098, 1108, 1115, 1129, 1131, 1153, 1166, 1169, 1174, 1270, 1315, 1359, 1377, 1380, 1391, 1414, 1539, 1559, 1576, 1626, 1661, 1674, 1690, 1702, 1707, 1712, 1717, 1737, 1792, 1798, 1862, 1870, 1967, 2004, 2032, 2036, 2052, 2076, 2121, 2185, 2230, 2266, 2311, 2316, 2320, 2348, 2366, 2388], 'development': [9, 75], 'and': [10, 108, 127, 170, 232, 235, 263, 299, 329, 348, 353, 369, 401, 431, 497, 567, 584, 601, 618, 639, 647, 657, 676, 691, 707, 729, 751, 819, 872, 896, 914, 956, 1006, 1049, 1055, 1074, 1082, 1105, 1124, 1136, 1162, 1168, 1178, 1203, 1207, 1227, 1249, 1289, 1297, 1305, 1330, 1350, 1385, 1394, 1419, 1428, 1434, 1439, 1445, 1453, 1469, 1486, 1493, 1501, 1518, 1529, 1537, 1550, 1580, 1590, 1613, 1631, 1637, 1651, 1665, 1720, 1758, 1765, 1787, 1826, 1833, 1852, 1854, 1882, 1887, 1895, 1897, 1946, 1952, 1961, 1993, 2018, 2116, 2151, 2167, 2217, 2235, 2245, 2332, 2342, 2359], 'homeostasis': [11], 'of': [12, 35, 57, 65, 139, 154, 158, 160, 175, 181, 191, 197, 215, 240, 256, 267, 274, 288, 292, 301, 307, 311, 342, 350, 382, 453, 515, 531, 550, 609, 642, 688, 726, 822, 845, 995, 1004, 1016, 1085, 1094, 1097, 1117, 1134, 1160, 1205, 1215, 1244, 1258, 1272, 1314, 1317, 1328, 1373, 1383, 1390, 1417, 1465, 1541, 1548, 1554, 1561, 1578, 1588, 1628, 1635, 1663, 1673, 1677, 1686, 1689, 1693, 1756, 1794, 1842, 1861, 1918, 2035, 2041, 2051, 2054, 2067, 2075, 2110, 2123, 2187, 2195, 2204, 2273, 2282, 2313, 2315, 2365, 2376, 2390, 2393], 'tissues.': [13, 2270], 'Too': [14], 'little': [15], 'death': [17, 28, 134, 336, 376, 455, 776, 783, 804, 841, 885, 1194, 1483, 1818, 1848, 1863], 'can': [18, 29, 415, 477, 579, 630, 694, 762, 934, 1034, 1060, 1285, 1309, 1352, 1533, 1615, 1779, 1963, 2044, 2079, 2129, 2218, 2373], 'result': [19, 1310, 1565], 'in': [20, 67, 94, 113, 141, 237, 242, 337, 418, 480, 494, 523, 745, 772, 826, 866, 880, 939, 1001, 1023, 1078, 1081, 1269, 1311, 1335, 1443, 1473, 1566, 1570, 1593, 1597, 1869, 2001, 2227, 2255, 2268, 2279, 2319, 2357, 2360, 2383], 'autoimmune': [21], 'diseases': [22, 34], 'cancer,': [24], 'whereas': [25, 802], 'excessive': [26], 'lead': [30], 'to': [31, 188, 271, 286, 303, 339, 379, 471, 526, 554, 562, 572, 637, 747, 768, 774, 793, 832, 840, 877, 882, 955, 1091, 1147, 1155, 1173, 1187, 1198, 1223, 1233, 1301, 1323, 1413, 1546, 1575, 1731, 1749, 1763, 1773, 1830, 1899, 1965, 1990, 2003, 2047, 2107, 2264, 2354, 2369, 2400], 'debilitating': [32], 'degenerative': [33], 'heart': [37], 'nervous': [39], 'system.': [40], 'The': [41, 136, 666, 815, 1656, 1723, 2039, 2192], 'realization': [42], 'that': [43, 54, 69, 84, 86, 116, 123, 132, 279, 372, 394, 410, 424, 437, 468, 652, 713, 905, 998, 1012, 1059, 1122, 1252, 1292, 1319, 1337, 1348, 1357, 1379, 1397, 1504, 1558, 1572, 1607, 1624, 1660, 1751, 1760, 1766, 1984, 2145, 2161, 2178, 2241, 2259], 'apoptosis': [44, 66, 140, 176, 479, 527, 727, 1571, 1598, 1905, 2055, 2322], 'was': [45, 52, 82], 'genetically': [46], 'controlled': [47, 1144], 'first': [48], 'arose': [49], 'when': [50, 950, 988], 'it': [51, 81, 1345, 1604], 'observed': [53], 'certain': [55, 195, 395, 565, 775], 'mutants': [56], 'model': [59, 1217, 1375, 1416, 1556, 1778, 1866], 'organism': [60], 'Caenorhabditis': [61], 'elegans': [62, 96], 'caused': [63, 907], 'failure': [64], 'cells': [68, 397, 420, 436, 460, 499, 547, 571, 875, 2197, 2244, 2356], 'normally': [70], 'undergo': [71, 878, 1156], 'this': [72, 145, 502, 823, 1216, 1374, 1509, 1555, 1783, 1873, 1909, 2249, 2260, 2402], 'process': [73, 966], 'during': [74, 963], '(Hengartner': [76, 107], 'et': [77, 614, 755, 779, 799, 812, 901, 917, 921, 925, 929, 968, 972, 976, 992, 1028, 1070, 1210, 1367, 1410, 1477, 1522, 1600, 1640, 1644, 1648, 1698, 1924, 1928, 1932, 1936, 1996, 2023, 2093, 2097, 2214, 2297, 2301], 'al.,': [78, 615, 756, 780, 800, 813, 902, 918, 922, 926, 930, 969, 973, 977, 993, 1029, 1071, 1211, 1368, 1411, 1478, 1523, 1601, 1641, 1645, 1649, 1699, 1925, 1929, 1933, 1937, 1997, 2024, 2094, 2098, 2215, 2298, 2302], '1992).': [79], 'Subsequently,': [80], 'found': [83, 409, 936, 2240], 'proteins': [85, 204, 211, 218, 356, 364, 404, 414, 448, 473, 514, 588, 623, 629, 651, 669, 683, 858, 910, 933, 1127, 1186, 1192, 1229, 1246, 1303, 1356, 1365, 1423, 1481, 1503, 1512, 1536, 1730, 1772, 1816, 1822, 1846, 1876, 1885, 1894, 1903, 1922, 2078, 2115, 2183, 2194, 2234, 2364, 2378], 'are': [87, 207, 277, 384, 438, 469, 602, 649, 658, 677, 740, 1120, 1387, 1398, 1513, 1622, 1753, 1761, 1789, 2105, 2179, 2198, 2290], 'encoded': [88], 'by': [89, 152, 177, 344, 361, 697, 743, 788, 790, 809, 842, 908, 1037, 1184, 1196, 1363, 1405, 1484, 1495, 1670, 1716, 1728, 1770, 1802, 1807, 1819, 1838, 1849, 1906, 2027, 2056, 2082, 2222], 'mutant': [91], 'genes': [92], 'discovered': [93], 'C.': [95], 'shared': [97], 'homology': [98, 594, 600], 'with': [99, 829, 945, 1247, 1355, 1438, 1695, 1804, 1920, 2201, 2363], 'mammalian': [100], 'proteins,': [101, 317, 1018, 1200, 1450, 1492, 1544, 1806, 1858, 1890, 2207], 'including': [102, 252, 294, 318, 702, 887, 1102, 1891], 'B-cell': [103], 'CLL/lymphoma': [104], '2': [105, 327], '(Bcl-2)': [106], 'Horvitz,': [109], '1994).': [110], 'Further': [111], 'study': [112], 'mammals': [114], 'revealed': [115], 'there': [117, 1621, 1752, 2132, 2328, 2336], 'an': [119, 128, 1234, 1294, 1312, 1467, 2136, 2380], 'intrinsic': [120, 868], 'apoptotic': [121, 130, 869], 'pathway': [122, 131, 138, 174], 'involves': [124, 133], 'mitochondria': [126, 2104], 'extrinsic': [129], 'receptors.': [135], 'mitochondrial': [137, 173, 184, 245, 533, 847, 948, 960, 985, 1088, 1099, 2321], 'mammals,': [142], 'on': [143, 386, 412, 440, 1706, 2072, 2135, 2155, 2173, 2181, 2292], 'which': [144, 248, 276, 597, 854, 1019, 1043, 1119, 1988, 2124], 'poster': [146, 509, 1871], 'article': [147], 'focused,': [149], 'regulated': [151], 'members': [153, 196, 549, 608, 821, 2314], 'Bcl-2': [156, 162, 199, 224, 312, 383, 387, 400, 443, 476, 486, 517, 552, 577, 593, 611, 1239, 1675, 2174, 2274, 2293, 2317, 2367], 'family': [157, 163, 518, 553, 578, 612, 824, 1676, 2318, 2368], 'proteins.Proteins': [159], 'have': [164, 408, 1682, 2009, 2239, 2248, 2307], 'either': [165, 1801], 'pro-': [166, 818], 'anti-apoptotic': [168, 316, 403, 413, 472, 585, 622, 820, 1185, 1199, 1235, 1245, 1302, 1324, 1364, 1535, 1729, 1771, 1857, 1875, 1912, 1968, 2077, 2138, 2182, 2193, 2224, 2377], 'activities': [169], 'regulate': [171], 'controlling': [178, 843], 'permeabilization': [180, 530, 844, 852, 1084, 1475, 1793], 'outer': [183, 244, 305, 534, 848, 850, 947, 961, 984, 1087], 'membrane.': [185, 535], 'In': [186, 434, 536, 758, 1508, 1619, 1782, 1828], 'response': [187, 338, 746, 773, 881, 2143, 2159], 'many': [189, 287, 340, 698, 883, 2010, 2242, 2304], 'types': [190, 2059], 'stress': [192, 899], 'damage,': [194, 704], 'family,': [200], 'known': [201, 260, 393, 659, 678, 737], 'as': [202, 261, 450, 461, 475, 660, 679, 685, 738, 937, 1041, 1238, 1275, 1341, 1432, 1617, 1633, 1745, 2209, 2285, 2287, 2396], 'BH3-only': [203, 210, 363, 447, 680, 682, 909, 1191, 1491, 1511, 1543, 1843, 1845, 1893, 2114, 2206], '(see': [205, 429, 2088], 'below),': [206], 'activated.': [208, 952], 'Certain': [209], 'cause': [212, 1083, 1538, 1847, 2370], 'activation': [214, 273, 347, 709, 965, 1003, 1116, 1142, 1164, 1204, 1327, 1547, 1662], 'pro-apoptotic': [217, 249, 446, 583, 650, 662, 668, 857, 1489, 1889, 2233], 'Bcl-2-associated': [219, 803], 'X': [220], 'protein': [221, 331, 444, 1236, 1913], '(Bax)': [222], 'antagonist/killer-1': [225], '(Bak)': [226], 'at': [227, 506, 2344], 'mitochondrion.': [229], 'Activated': [230], 'Bax': [231, 352, 368, 646, 871, 913, 932, 953, 1005, 1047, 1054, 1073, 1135, 1161, 1177, 1206, 1226, 1248, 1288, 1318, 1329, 1349, 1384, 1393, 1418, 1444, 1500, 1528, 1549, 1579, 1636, 1664, 1696, 1708, 1757, 1786, 1825, 1832, 1853, 1896, 2341], 'Bak': [233, 648, 873, 915, 979, 1007, 1056, 1075, 1137, 1163, 1179, 1208, 1228, 1250, 1259, 1290, 1331, 1351, 1386, 1395, 1420, 1502, 1530, 1638, 1666, 1759, 1788, 1834, 1855, 2343], 'homo-oligomerize': [234], 'participate': [236, 1077], 'formation': [239], 'pores': [241, 1080], 'membrane': [246, 851, 949, 962, 986, 1474], 'through': [247], 'molecules': [250], 'escape,': [251], 'second': [253], 'mitochondria-derived': [254], 'activator': [255, 1422, 1490, 1517, 1542, 1805, 1821, 1892, 2205, 2331], 'caspase': [257, 791], '(Smac)': [258], '(also': [259], 'Diablo)': [262], 'cytochrome': [264, 268, 1103], 'c.': [265], 'Release': [266], 'c': [269, 1104], 'leads': [270, 285, 1989], 'caspases,': [275, 1118], 'proteases': [278, 1121], 'cleave': [280, 1123], 'key': [281, 561, 1146, 2403], 'cellular': [282, 689], 'proteins.': [283, 586, 665, 681, 1325, 1678, 1969], 'This': [284, 1031, 1308, 1865, 1999], 'morphological': [290], 'characteristics': [291], 'condensed': [295], 'nuclei,': [296], 'DNA': [297, 703, 748, 894], 'laddering': [298], 'exposure': [300], 'phosphatidylserine': [302], 'leaflet': [306], 'plasma': [309], 'membrane.Expression': [310], 'other': [314, 402, 831, 1406, 1610, 1812, 2329], 'related': [315], 'myeloid': [319], 'leukemia-1': [321], '(Mcl-1),': [322], 'Bcl-2-like': [323, 326], '1': [324], '(Bcl-XL),': [325], '(Bcl-w)': [328], 'Bcl-2-related': [330], 'A1': [332], '(Bfl-1),': [333], 'block': [334, 555, 1569], 'varieties': [341], 'insult': [343], 'preventing': [345], 'homo-oligomerization': [349], 'both': [351], 'Bak.': [354, 370, 1446, 1551, 1581, 1827], 'Anti-apoptotic': [355, 1480, 1815, 1884], 'perform': [357, 2101], 'their': [358, 389, 1141, 1189], 'anti-death': [359], 'function': [360, 638], 'sequestering': [362, 1487, 1820], 'activated,': [366, 1400], 'monomeric': [367], 'Cells': [371, 2177], 'survive': [373], 'continuous,': [374], 'permanent': [375], 'signaling': [377], 'owing': [378], 'presence': [381, 1271], 'dependent': [385, 439, 2180, 2291], 'survival.': [390, 406], 'It': [391], 'cancer': [396, 419, 435, 482, 546, 2243], 'depend': [398], 'upon': [399], 'We': [407, 457, 2238, 2386], 'dependence': [411, 2066, 2134, 2154, 2172], 'be': [416, 580, 631, 695, 763, 769, 935, 1035, 1061, 1182, 1231, 1347, 1506, 1668, 1768, 1780, 2045, 2080, 2219, 2265, 2379], 'identified': [417], 'using': [421, 1448, 2060], 'a': [422, 507, 836, 1009, 1150, 1221, 1255, 1567, 1585, 1684, 1687, 1776, 1840, 1981, 2061, 2068, 2083, 2108, 2142, 2158], 'strategy': [423, 2272], 'we': [425, 511, 538, 2351], 'call': [426], 'BH3': [427, 1691, 1721, 1733, 1982, 2064, 2086, 2102], 'profiling': [428, 2087], 'below': [430], 'Box': [432, 2090], '1).': [433], 'Bcl-2,': [441, 1878, 1944], 'binds': [445, 1943, 1950, 1986], 'such': [449, 459, 474, 485, 1040, 1237, 1274, 1340, 1431, 1466, 1488, 2196, 2208, 2284, 2395], 'Bcl-2-interacting': [451], 'mediator': [452], '(Bim).': [456], 'describe': [458], 'being': [462, 2188, 2277], '`primed': [463, 2189], "death'.": [465, 2191], 'Molecular': [466], 'therapies': [467], 'targeted': [470], 'induce': [478, 1287, 1440, 2126], 'primed': [481], 'cells;': [483], 'one': [484, 590, 1746, 2074, 2128], 'antagonist,': [487], 'Abbott': [488], '(ABT)-737,': [489], 'has': [490, 1461, 1914, 1971], 'shown': [491], 'impressive': [492], 'success': [493], 'killing': [495], 'leukemia': [496], 'lymphoma': [498], '(Table': [500, 2398], '1).In': [501], 'brief': [503], 'Cell': [504], 'Science': [505], 'Glance': [508], 'article,': [510], 'discuss': [512, 539], 'how': [513, 545, 564, 1140, 1149], 'control': [519, 2053], 'crucial': [521, 1126], 'event': [522, 865], 'commitment': [525], '–': [528, 701, 710], 'addition,': [537], 'recently': [540], 'developed': [541], 'methods': [542], 'probing': [544], 'manipulate': [548], 'apoptosis.': [556, 1157, 1901, 2237], 'Understanding': [557], 'these': [558, 2042], 'principles': [559], 'understanding': [563, 1139, 1148], 'insults': [566], 'derangements': [568], 'commit': [569, 839], 'selected': [570], 'but': [574, 1532, 1603, 2252], 'spare': [575], 'others.The': [576], 'divided': [581, 632, 1515], 'into': [582, 633, 859, 958, 982, 1107, 1516], 'These': [587, 1112, 1283], 'contain': [589, 624, 653, 670, 1338], 'more': [592], '(BH)': [595], 'domains,': [596], 'share': [598, 2184], 'sequence': [599], 'heterodimeric': [605], 'interactions': [606, 828, 2043], 'among': [607], '(Chittenden': [613], '1995;': [616], 'Danial': [617], 'Korsmeyer,': [619], '2004).': [620], 'Most': [621], 'BH': [625, 643, 654, 674], 'domains': [626, 644, 655], '1-4.': [627], 'Pro-apoptotic': [628], 'two': [634, 1738], 'groups': [635], 'according': [636], 'number': [641], 'possessed.': [645], '1-3': [656], 'multidomain': [661], 'effector': [664], 'remaining': [667], 'only': [671, 771, 1254, 1839], 'third': [673], 'domain': [675, 1692, 1983], 'act': [684, 1616], 'upstream': [686], 'sentinels': [687], 'damage': [690, 749, 895], 'derangement.': [692], 'They': [693, 1796], 'activated': [696, 787, 808, 990, 1032, 1295, 1499, 1754, 1785, 1799, 1824], 'noxious': [699, 2349], 'stimuli': [700, 777, 2350], 'growth-factor': [705, 892], 'withdrawal': [706], 'oncogene': [708], 'via': [711, 1063, 1811], 'mechanisms': [712, 2338], 'include': [714, 1376, 1425, 1877], 'transcriptional': [715], 'upregulation,': [716], 'subcellular': [717], 'localization': [718], 'and/or': [719, 1240], 'post-translational': [720], 'modifications.': [721], 'For': [722, 1939, 2140], 'example,': [723, 1940, 2141], 'p53-upregulated': [724], 'modulator': [725], '(Puma)': [728], 'Noxa': [730, 1948], '(the': [731], 'latin': [732], 'word': [733], 'damage;': [735], 'also': [736, 1494, 2089], 'PMAIP1)': [739], 'transcriptionally': [741], 'upregulated': [742], 'p53': [744, 1630], '(Nakano': [750], 'Vousden,': [752], '2001;': [753], 'Oda': [754], '2000).': [757, 1072], 'some': [759, 2288], 'cells,': [760], 'Bim': [761, 1427, 1591, 1614, 1694, 2210], 'sequestered': [764, 1381, 1769], 'within': [765], 'cytoskeleton,': [767], 'released': [770], '(Puthalakath': [778], '1999).': [781], 'BH3-interacting-domain': [782], 'agonist': [784], '(Bid)': [785], 'cleavage': [789], '8': [792], 'form': [794, 1057], 'truncated': [795], 'Bid': [796, 1589, 1612, 1960], '(tBID)': [797], '(Li': [798], '1998),': [801], 'promoter': [805], '(Bad)': [806], 'dephosphorylation': [810], '(Zha': [811], '1996).': [814], 'relatively': [816, 1594], 'numerous': [817, 856, 2005], 'engage': [825], 'complex': [827, 1688], 'each': [830], 'ultimately': [833], 'decide': [834], 'whether': [835, 2131], 'will': [838], 'membrane.Mitochondrial': [849], '(MOMP),': [853], 'releases': [855, 2229], 'cytosol,': [861], 'pivotal': [864], 'pathway.': [870], 'double-knockout': [874], 'fail': [876], 'MOMP': [879, 2117], 'different': [884], 'stimuli,': [886], 'staurosporine,': [888], 'ultraviolet': [889], '(UV)': [890], 'radiation,': [891], 'deprivation,': [893], 'endoplasmic': [897], 'reticulum': [898], '(Wei': [900, 991, 1069], '2001).': [903, 931, 1111], 'Apoptosis': [904], 'absolutely': [911], 'requires': [912], '(Kuwana': [916], '2005;': [919, 1930, 1934, 2299], 'Lindsten': [920], '2000;': [923, 927], 'Wei': [924, 928], 'monomers': [938], 'cytosol': [941, 1109], 'loosely': [943], 'associated': [944], 'not': [951, 989, 1333, 1741], 'translocates': [954], 'inserts': [957], '(Billen': [967], '2008;': [970], 'Hsu': [971], '1997;': [974], 'Wolter': [975], '1997).': [978, 1051, 1307], 'inserted': [981], 'even': [987], '2000).One': [994], 'steps': [997], 'involved': [1000], 'conformational': [1010, 1441], 'change': [1011], 'exposes': [1013], 'N-terminus': [1015], 'otherwise': [1021], 'hidden': [1022], 'inactive': [1025], 'state': [1026, 1296, 1800], '(Yethon': [1027], '2003).': [1030, 1369, 1938], 'conformation': [1033], 'recognized': [1036], 'conformation-specific': [1038], 'antibodies,': [1039], '6A7,': [1042], 'specific': [1045, 1956], '(Hsu': [1048, 1304], 'Youle,': [1050, 1306], 'Following': [1052], 'activation,': [1053, 1138, 1421], 'homo-oligomers': [1058], 'visualized': [1062], 'western': [1064], 'blotting': [1065], 'following': [1066], 'chemical': [1067], 'crosslinking': [1068], 'oligomers': [1076], 'forming': [1079], 'membrane,': [1089], 'leading': [1090, 1545], 'release': [1093, 1202, 1540], 'contents': [1096, 1113], 'intermembrane': [1100], 'space,': [1101], 'Smac,': [1106], '(Wang,': [1110], 'drive': [1114], 'disable': [1125], 'throughout': [1128], 'cell.Given': [1130], 'lethal': [1132], 'consequences': [1133], 'makes': [1152], 'decision': [1154], 'Two': [1158], 'models': [1159, 1739], 'exist:': [1165], 'indirect': [1167, 1175], 'direct': [1170, 1415, 2374], 'models.': [1171], 'According': [1172], 'model,': [1176, 1510, 1784], 'must': [1180, 1230, 1767], 'always': [1181], 'bound': [1183, 1232, 1322, 2231], 'prevent': [1188, 1482, 1900], 'activation.': [1190], 'provoke': [1193, 1904], 'solely': [1195], 'binding': [1197, 1300, 1485, 1496], 'causing': [1201], '(Willis': [1209, 1599], '2007).': [1212, 2099], 'A': [1213, 1552, 2271], 'prediction': [1214, 1553], 'that,': [1219], 'survive,': [1224], 'all': [1225, 1562, 1966], 'Mcl-1.': [1241, 2156], 'However,': [1242, 1344], 'co-immunoprecipitation': [1243, 1264], 'demonstrates': [1251], 'usually': [1253], 'small': [1256], 'minority': [1257], 'so': [1261], 'bound.': [1262], 'Furthermore,': [1263], 'often': [1266], 'carried': [1267], 'out': [1268], 'detergents': [1273, 1284, 1339], 'Triton': [1276], 'X-100': [1277], 'Tergitol-type': [1279], 'nonyl': [1280], 'phenoxylpolyethoxylethanol-40': [1281], '(NP-40).': [1282], 'artificially': [1286], 'conformations': [1291], 'mimic': [1293], 'stimulate': [1298], 'artifactual': [1299], 'overestimation': [1313], 'amount': [1316], 'actually': [1321], 'Artificial': [1326], 'does': [1332], 'occur': [1334], 'buffers': [1336], '3-[3-(Cholamidopropyl)dimethyl-ammonio]-1-propanesulfonate': [1342], '(CHAPS).': [1343], 'might': [1346, 1505, 1667, 2029], 'alternatively': [1353], 'interact': [1354, 1437, 2362], 'remove': [1358], 'requirement': [1360], 'sequestration': [1362], '(Cheng': [1366], 'More': [1370], 'recent': [1371, 1680], 'iterations': [1372], 'concept': [1378], 'forms': [1382], 'those': [1388], 'fractions': [1389], 'total': [1392], 'population': [1396], 'already': [1399, 2199], 'perhaps': [1401, 1404], 'spontaneously,': [1402], 'unspecified': [1407], 'means': [1408], '(Fletcher': [1409], '2008).According': [1412], '(which': [1424], 'Bid,': [1426, 2148, 2164], 'possibly': [1429, 1652], 'others': [1430, 1653], 'Puma': [1433, 1962, 2150, 2166], 'p53)': [1435], 'directly': [1436], 'changes': [1442], 'Studies': [1447], 'full-length': [1449], 'lipid': [1451], 'membranes': [1452], 'real-time': [1454], 'fluorescence': [1455], 'resonance': [1456], 'energy': [1457], 'transfer': [1458], '(FRET)': [1459], 'analyses': [1460], 'provided': [1462], 'convincing': [1463], 'evidence': [1464], 'interaction': [1468, 1703, 1919], 'its': [1471, 1915], 'role': [1472, 1627], '(Lovell': [1476], '2008).': [1479, 1700], 'any': [1497, 2073], 'monomeric,': [1498], 'present.': [1507], 'further': [1514], 'sensitizer': [1519, 1921, 2333], 'categories': [1520], '(Letai': [1521], '2002).': [1524], 'Sensitizers': [1525], 'cannot': [1526], 'activate': [1527], 'directly,': [1531], 'bind': [1534, 1732, 1886, 1964], 'deletion': [1560], 'activators': [1563, 1634, 1851], 'would': [1564], 'profound': [1568], 'equivalent': [1574], 'loss': [1577], 'By': [1582], 'contrast,': [1583], 'however,': [1584], 'combined': [1586], 'knockout': [1587], 'results': [1592, 1681, 2254, 2389], 'minor': [1595], 'defects': [1596], '2007),': [1602, 2216], 'likely': [1606, 2263], 'additional': [1608, 1972], 'factors': [1609, 1671], 'than': [1611], 'activators.': [1618], 'fact,': [1620], 'data': [1623], 'support': [1625], 'Puma,': [1629], 'heat': [1632], '(Chipuk': [1639], '2004;': [1642], 'Kim': [1643], '2006;': [1646, 1926, 2095], 'Pagliari': [1647], '2005),': [1650], 'remain': [1654], 'undiscovered.': [1655], 'point': [1658], 'affected': [1669], 'outside': [1672], 'Very': [1679], 'demonstrated': [1683], 'structure': [1685], '(Gavathiotis': [1697], 'Surprisingly,': [1701], 'takes': [1704], 'place': [1705], 'surface': [1709], 'distal': [1710], 'from': [1711, 1856, 2113], 'hydrophobic': [1713], 'pocket': [1714, 1725], 'formed': [1715], 'BH1,': [1718], 'BH2': [1719], 'domains.': [1722], 'analogous': [1724], 'used': [1727], 'domains.The': [1734], 'gulf': [1735], 'between': [1736], 'unbridgeable.': [1742], 'As': [1743], 'long': [1744], 'willing': [1748], 'accept': [1750], 'subsets': [1755], 'required': [1762], 'kill,': [1764], 'maintain': [1774], 'survival,': [1775], 'unifying': [1777], 'constructed.': [1781], 'responsible': [1790], 'membranes.': [1795], 'achieve': [1797], 'interacting': [1803], 'spontaneously': [1808], 'activating,': [1809], 'unknown': [1813], 'means.': [1814], 'inhibit': [1817], 'addition': [1829, 2002], 'activating': [1831], '(a': [1835], 'property': [1836], 'possessed': [1837, 2026], 'subset': [1841], 'proteins),': [1844], 'displacing': [1850], 'permitting': [1859], 'progression': [1860], 'signal.': [1864], 'summarized': [1868], 'accompanying': [1872], 'article.Mammalian': [1874], 'Bcl-XL,': [1879], 'Mcl-1,': [1880, 1987, 2028], 'Bcl-w': [1881], 'Bfl-1.': [1883], 'sequester': [1888], 'Bak,': [1898], 'Sensitizer': [1902], 'competitively': [1907], 'inhibiting': [1908, 2223], 'interaction.': [1910], 'Each': [1911], 'own': [1916], 'pattern': [1917, 2144, 2160], '(Certo': [1923, 2092], 'Chen': [1927], 'Kuwana': [1931], 'Opferman': [1935], 'Bad': [1941], 'selectively': [1942], 'Bcl-XL': [1945], 'Bcl-w;': [1947], 'specifically': [1949, 1985], 'Mcl-1;': [1951], 'Harakiri': [1953], '(Hrk)': [1954], 'Bcl-XL.': [1958], 'Bim,': [1959, 2147, 2163], 'Mcl-1': [1970, 1975, 1991, 2037], 'unique': [1973], 'characteristics.': [1974], 'ubiquitylation': [1976, 1992], 'ligase': [1977], 'E3': [1978], '(MULE)': [1979], 'contains': [1980], 'degradation': [1994], '(Zhong': [1995], '2005).': [1998], 'interaction,': [2000], 'PEST': [2006], 'sequences': [2007], '[which': [2008], 'proline': [2011], '(P),': [2012], 'glutamic': [2013], 'acid': [2014], '(E),': [2015], 'serine': [2016], '(S)': [2017], 'threonine': [2019], '(T)': [2020], 'residues': [2021], '(Kozopas': [2022], '1993)]': [2025], 'account': [2030], 'short': [2033], 'half-life': [2034], 'protein.': [2038, 2139], 'specificity': [2040], 'exploited': [2046], 'deduce': [2048], 'elements': [2050], 'individual': [2057, 2137], 'procedure': [2062], 'called': [2063, 2085], 'profiling.The': [2065], 'mitochondrion': [2071], 'detected': [2081], 'technique': [2084], '1)': [2091, 2399], 'Deng': [2096], 'To': [2100], 'profiling,': [2103], 'exposed': [2106], 'panel': [2109], 'BH3-domain': [2111], 'peptides': [2112, 2125], 'measured.': [2119], 'On': [2120], 'basis': [2122], 'MOMP,': [2127], 'discern': [2130], 'includes': [2146, 2162], 'Noxa,': [2149], 'Bmf': [2152], 'suggests': [2153, 2171, 2258], 'Alternatively,': [2157], 'Bad,': [2165], 'Bcl-2-modifying': [2168], 'factor': [2169], '(Bmf)': [2170], 'Bcl-w.': [2176], 'characteristic': [2186], 'burdened': [2200], 'significant': [2202], 'amounts': [2203], '(Del': [2211], 'Gaizo': [2212], 'Moore': [2213], 'killed': [2220], 'merely': [2221], 'function.': [2225], 'This,': [2226], 'turn,': [2228], 'pre-existing': [2232], 'provokes': [2236], 'lines': [2247], "`primed'": [2250], 'phenotype,': [2251], 'limited': [2253], 'normal': [2256, 2269], 'tissues': [2257], 'less': [2262], 'case': [2267], 'antagonism': [2275], 'employed': [2278], 'clinical': [2280, 2391], 'trials': [2281, 2392], 'agents': [2283], 'ABT-263,': [2286], 'cancers': [2289], 'survival': [2295], '(Oltersdorf': [2296], 'Tse': [2300], '2008).Although': [2303], 'discoveries': [2306], 'been': [2308], 'made': [2309], 'regarding': [2310], 'roles': [2312], 'pathway,': [2323], 'questions': [2325], 'remain.': [2326], 'Are': [2327, 2335], 'proteins?': [2334], 'undiscovered': [2337], 'holding': [2340], 'bay?': [2345], 'How': [2346], 'do': [2347], 'routinely': [2352], 'use': [2353], 'kill': [2355], 'culture': [2358], 'vivo': [2361], 'apoptosis?': [2371], 'Finally,': [2372], 'inhibition': [2375], 'effective': [2381], 'tool': [2382], 'treating': [2384], 'cancer?': [2385], 'await': [2387], 'drugs': [2394], 'ABT-263': [2397], 'answer': [2401], 'question.': [2404]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162574319', 'counts_by_year': [{'year': 2024, 'cited_by_count': 26}, {'year': 2023, 'cited_by_count': 49}, {'year': 2022, 'cited_by_count': 31}, {'year': 2021, 'cited_by_count': 62}, {'year': 2020, 'cited_by_count': 61}, {'year': 2019, 'cited_by_count': 60}, {'year': 2018, 'cited_by_count': 60}, {'year': 2017, 'cited_by_count': 60}, {'year': 2016, 'cited_by_count': 69}, {'year': 2015, 'cited_by_count': 67}, {'year': 2014, 'cited_by_count': 66}, {'year': 2013, 'cited_by_count': 78}, {'year': 2012, 'cited_by_count': 67}], 'updated_date': '2025-01-11T22:10:33.419160', 'created_date': '2016-06-24'}